Nadia Arang, PhD
Postdoctoral Scholar
Quantitative_Bioscience_Ins
School of Pharmacy

Publications (27)

Top publication keywords:
MelanomaFocal Adhesion Kinase 1GTP-Binding Protein alpha SubunitsHeterotrimeric GTP-Binding ProteinsPhosphatidylinositol 3-KinasesGTP-Binding Protein alpha Subunits, Gq-G11Focal Adhesion Protein-Tyrosine KinasesCarcinogenesisUveal NeoplasmsProto-Oncogene Proteins c-aktReceptors, G-Protein-CoupledMalariaSporozoitesSignal TransductionPlasmodium yoelii

• Using machine learning to dissect host kinases required for Leishmania internalization and development.
  Molecular and biochemical parasitology 2024 Wei L, Barrie U, Aloisio GM, Khuong FTH, Arang N, Datta A, Kaushansky A, Wetzel DM
• Using machine learning to dissect host kinases required for Leishmania internalization and development.
  bioRxiv : the preprint server for biology 2024 Wei L, Barrie U, Aloisio GM, Khuong FTH, Arang N, Datta A, Kaushansky A, Wetzel DM
• Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation.
  NPJ systems biology and applications 2024 Trogdon M, Abbott K, Arang N, Lande K, Kaur N, Tong M, Bakhoum M, Gutkind JS, Stites EC
• A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC.
  Cancer research communications 2024 Goto Y, Koshizuka K, Ando T, Izumi H, Wu X, Sato K, Ishikawa T, Ford K, Feng X, Wang Z, Arang N, Allevato MM, Kishore A, Mali P, Gutkind JS
• Targeting a lineage-specific PI3Kɣ-Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule.
  Nature cancer 2024 Kelly LM, Rutter JC, Lin KH, Ling F, Duchmann M, Latour E, Arang N, Pasquer H, Ho Nhat D, Charles J, Killarney ST, Ang HX, Namor F, Culeux C, Lombard B, Loew D, Swaney DL, Krogan NJ, Brunel L, …

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• High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma.
  Cell reports. Medicine 2023 Arang N, Lubrano S, Ceribelli M, Rigiracciolo DC, Saddawi-Konefka R, Faraji F, Ramirez SI, Kim D, Tosto FA, Stevenson E, Zhou Y, Wang Z, Bogomolovas J, Molinolo AA, Swaney DL, Krogan NJ, Yang J, Coma …
• Catalytic site mutations confer multiple states of G protein activation.
  Science signaling 2023 Hewitt N, Ma N, Arang N, Martin SA, Prakash A, DiBerto JF, Knight KM, Ghosh S, Olsen RHJ, Roth BL, Gutkind JS, Vaidehi N, Campbell SL, Dohlman HG
• Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ-focal adhesion kinase signaling circuitry.
  The Journal of biological chemistry 2022 Arang N, Lubrano S, Rigiracciolo DC, Nachmanson D, Lippman SM, Mali P, Harismendy O, Gutkind JS
• A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection.
  Cell chemical biology 2022 Vijayan K, Arang N, Wei L, Morrison R, Geiger R, Parks KR, Lewis AJ, Mast FD, Douglass AN, Kain HS, Aitchison JD, Johnson JS, Aderem A, Kaushansky A
• Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC).
  Journal of experimental & clinical cancer research : CR 2022 Rigiracciolo DC, Nohata N, Lappano R, Cirillo F, Talia M, Adame-Garcia SR, Arang N, Lubrano S, De Francesco EM, Belfiore A, Gutkind JS, Maggiolini M
• Cyclosporine Induces Fenestra-Associated Injury in Human Renal Microvessels In Vitro.
  ACS biomaterials science & engineering 2021 Nagao RJ, Marcu R, Shin YJ, Lih D, Xue J, Arang N, Wei L, Akilesh S, Kaushansky A, Himmelfarb J, Zheng Y
• EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1.
  Communications biology 2021 Ando T, Arang N, Wang Z, Costea DE, Feng X, Goto Y, Izumi H, Gilardi M, Ando K, Gutkind JS
• Gαs-Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling.
  Pharmacological reviews 2021 Ramms DJ, Raimondi F, Arang N, Herberg FW, Taylor SS, Gutkind JS
• Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Paradis JS, Acosta M, Saddawi-Konefka R, Kishore A, Lubrano S, Gomes F, Arang N, Tiago M, Coma S, Wu X, Ford K, Day CP, Merlino G, Mali P, Pachter JA, Sato T, Aplin AE, Gutkind JS
• Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Paradis JS, Acosta M, Saddawi-Konefka R, Kishore A, Gomes F, Arang N, Tiago M, Coma S, Lubrano S, Wu X, Ford K, Day CP, Merlino G, Mali P, Pachter JA, Sato T, Aplin AE, Gutkind JS
• G Protein-Coupled receptors and heterotrimeric G proteins as cancer drivers.
  FEBS letters 2020 Arang N, Gutkind JS
• Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis.
  Oncogene 2020 Goto Y, Ando T, Izumi H, Feng X, Arang N, Gilardi M, Wang Z, Ando K, Gutkind JS
• Illuminating G-Protein-Coupling Selectivity of GPCRs.
  Cell 2019 Inoue A, Raimondi F, Kadji FMN, Singh G, Kishi T, Uwamizu A, Ono Y, Shinjo Y, Ishida S, Arang N, Kawakami K, Gutkind JS, Aoki J, Russell RB
• Liver stage malaria infection is controlled by host regulators of lipid peroxidation.
  Cell death and differentiation 2019 Kain HS, Glennon EKK, Vijayan K, Arang N, Douglass AN, Fortin CL, Zuck M, Lewis AJ, Whiteside SL, Dudgeon DR, Johnson JS, Aderem A, Stevens KR, Kaushansky A
• Alterations in Phosphorylation of Hepatocyte Ribosomal Protein S6 Control Plasmodium Liver Stage Infection.
  Cell reports 2019 Glennon EKK, Austin LS, Arang N, Kain HS, Mast FD, Vijayan K, Aitchison JD, Kappe SHI, Kaushansky A
• Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential.
  Science signaling 2019 Bandekar SJ, Arang N, Tully ES, Tang BA, Barton BL, Li S, Gutkind JS, Tesmer JJG
• A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK.
  Cancer cell 2019 Feng X, Arang N, Rigiracciolo DC, Lee JS, Yeerna H, Wang Z, Lubrano S, Kishore A, Pachter JA, König GM, Maggiolini M, Kostenis E, Schlaepfer DD, Tamayo P, Chen Q, Ruppin E, Gutkind JS
• Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles.
  Nature communications 2017 Arang N, Kain HS, Glennon EK, Bello T, Dudgeon DR, Walter ENF, Gujral TS, Kaushansky A
• Malaria parasites target the hepatocyte receptor EphA2 for successful host infection.
  Science (New York, N.Y.) 2015 Kaushansky A, Douglass AN, Arang N, Vigdorovich V, Dambrauskas N, Kain HS, Austin LS, Sather DN, Kappe SH
• Host-based Prophylaxis Successfully Targets Liver Stage Malaria Parasites.
  Molecular therapy : the journal of the American Society of Gene Therapy 2015 Douglass AN, Kain HS, Abdullahi M, Arang N, Austin LS, Mikolajczak SA, Billman ZP, Hume JCC, Murphy SC, Kappe SHI, Kaushansky A
• Susceptibility to Plasmodium yoelii preerythrocytic infection in BALB/c substrains is determined at the point of hepatocyte invasion.
  Infection and immunity 2014 Kaushansky A, Austin LS, Mikolajczak SA, Lo FY, Miller JL, Douglass AN, Arang N, Vaughan AM, Gardner MJ, Kappe SH
• SSP3 is a novel Plasmodium yoelii sporozoite surface protein with a role in gliding motility.
  Infection and immunity 2014 Harupa A, Sack BK, Lakshmanan V, Arang N, Douglass AN, Oliver BG, Stuart AB, Sather DN, Lindner SE, Hybiske K, Torii M, Kappe SH