Myriam Chaumeil, PhD
Professor
Physical Therapy
School of Medicine

She is also a research group leader in Metabolic Imaging of Neurological disorders, a core member of the UCSF/UC Berkeley BioEngineering Graduate Program, a core member of the UCSF Biomedical Science Graduate program, a core member of the UCSF PhD in Rehabilitation Science Graduate Program, and a faculty member of the California Institute for Quantitative Biosciences (QBI).

Dr. Chaumeil's research focuses on developing and validating magnetic resonance (MR)-based imaging and spectroscopy methods for in vivo measurement of brain metabolism, in physiological and pathological conditions, in preclinical models and in patients. She has experience in studies of Huntington’s disease, Multiple Sclerosis, Alzheimer’s disease, Traumatic Brain Injury, cerebral small vascular diseases and CNS lymphoma. She has extensive internationally recognized expertise in MR metabolic imaging, particularly in state-of-the-art hyperpolarized 13C MRS method, and has a particular interest in expanding the use of this MR metabolic imaging method to the study of neurodegeneration with an ultimate goal of clinical translation.

Dr. Chaumeil concurrently obtained a Engineer Diploma - Physics Major - from the Ecole Superieure de Physique et Chimie Industrielles de Paris (EPSCI) and a Master in Medical Imaging from the University of Paris XI/Orsay. She then received her PhD in medical imaging for her graduate work on developing innovative MR spectroscopy approaches for the study of brain metabolism. She completed a postdoctoral fellowship at UCSF before joining the faculty in 2016.

• [18F]F-AraG imaging reveals association between neuroinflammation and brown- and bone marrow adipose tissue.
  Communications biology 2024 Levi J, Guglielmetti C, Henrich TJ, Yoon JC, Gokhale PC, Reardon DA, Packiasamy J, Huynh L, Cabrera H, Ruzevich M, Blecha J, Peluso MJ, Huynh TL, An SM, Dornan M, Belanger AP, Nguyen QD, Seo Y, Song H…
• New Horizons in Hyperpolarized 13C MRI.
  Molecular imaging and biology 2023 Chaumeil MM, Bankson JA, Brindle KM, Epstein S, Gallagher FA, Grashei M, Guglielmetti C, Kaggie JD, Keshari KR, Knecht S, Laustsen C, Schmidt AB, Vigneron D, Yen YF, Schilling F
• Impaired intracellular Ca2+ signaling contributes to age-related cerebral small vessel disease in Col4a1 mutant mice.
  Science signaling 2023 Yamasaki E, Thakore P, Ali S, Sanchez Solano A, Wang X, Gao X, Labelle-Dumais C, Chaumeil MM, Gould DB, Earley S
• Protocol to combine brain sections from multiple mice into a single block for spatial transcriptomic analyses.
  STAR protocols 2023 Sei YJ, Chaumeil MM, Nakamura K
• PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Thakore P, Yamasaki E, Ali S, Sanchez Solano A, Labelle-Dumais C, Gao X, Chaumeil MM, Gould DB, Earley S
• Hyperpolarized 13C metabolic imaging detects long-lasting metabolic alterations following mild repetitive traumatic brain injury.
  Research square 2023 Chaumeil M, Guglielmetti C, Qiao K, Tiret B, Ozen M, Krukowski K, Nolan A, Paladini MS, Lopez C, Rosi S
• Imaging immunomodulatory treatment responses in a multiple sclerosis mouse model using hyperpolarized 13C metabolic MRI.
  Communications medicine 2023 Guglielmetti C, Cordano C, Najac C, Green AJ, Chaumeil MM
• Neurons require glucose uptake and glycolysis in vivo.
  Cell reports 2023 Li H, Guglielmetti C, Sei YJ, Zilberter M, Le Page LM, Shields L, Yang J, Nguyen K, Tiret B, Gao X, Bennett N, Lo I, Dayton TL, Kampmann M, Huang Y, Rathmell JC, Vander Heiden M, Chaumeil MM, Nakamura…
• PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease.
  bioRxiv : the preprint server for biology 2023 Thakore P, Yamasaki E, Ali S, Solano AS, Labelle-Dumais C, Gao X, Chaumeil MM, Gould DB, Earley S
• Preclinical Development of NRTX-1001, an Inhibitory Interneuron Cellular Therapeutic for the Treatment of Chronic Focal Epilepsy (S13.007).
  Neurology 2022 Mansi Parekh, Philip Hampel, Marina Radoul, Eric Steven Sevilla, David Traver, Hannah Kim, Nathalie Picard, Andrew Adler, Luis Fuentealba, Jiayin Li, Adrian Bates, Daniel Cherkowsky, Marina Bershteyn,…
• Empowering Data Sharing and Analytics through the Open Data Commons for Traumatic Brain Injury Research.
  Neurotrauma reports 2022 Chou A, Torres-Espín A, Huie JR, Krukowski K, Lee S, Nolan A, Guglielmetti C, Hawkins BE, Chaumeil MM, Manley GT, Beattie MS, Bresnahan JC, Martone ME, Grethe JS, Rosi S, Ferguson AR
• Evidence for glutamine synthetase function in mouse spinal cord oligodendrocytes.
  Glia 2021 Ben Haim L, Schirmer L, Zulji A, Sabeur K, Tiret B, Ribon M, Chang S, Lamers WH, Boillée S, Chaumeil MM, Rowitch DH
• Non-Invasive Differentiation of M1 and M2 Activation in Macrophages Using Hyperpolarized 13C MRS of Pyruvate and DHA at 1.47 Tesla.
  Metabolites 2021 Qiao K, Le Page LM, Chaumeil MM
• Longitudinal Imaging of T Cells and Inflammatory Demyelination in a Preclinical Model of Multiple Sclerosis Using 18F-FAraG PET and MRI.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2021 Guglielmetti C, Levi J, Huynh TL, Tiret B, Blecha J, Tang R, VanBrocklin H, Chaumeil MM
• 8 Neurological applications of hyperpolarized 13C MR.
  2021 Myriam M. Chaumeil
• Imaging ketone metabolism in the brain in Alzheimer's disease using hyperpolarized 13C spectroscopy.
  Alzheimer's & Dementia 2020 Lydia M Le Page, Soo Hyun Shin, Kai Qiao, Myriam M Chaumeil
• First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism.
  Journal of magnetic resonance (San Diego, Calif. : 1997) 2019 Chung BT, Chen HY, Gordon J, Mammoli D, Sriram R, Autry AW, Le Page LM, Chaumeil MM, Shin P, Slater J, Tan CT, Suszczynski C, Chang S, Li Y, Bok RA, Ronen SM, Larson PEZ, Kurhanewicz J, Vigneron DB
• HDAC inhibition in glioblastoma monitored by hyperpolarized 13 C MRSI.
  NMR in biomedicine 2018 Radoul M, Najac C, Viswanath P, Mukherjee J, Kelly M, Gillespie AM, Chaumeil MM, Eriksson P, Delos Santos R, Pieper RO, Ronen SM
• Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NFkB Activation in Preclinical Patient-Derived Models of CNS Lymphoma.
  Blood 2018 Huimin Geng, Brice Tiret, Hua-Xin Gao, Cigall Kadoch, Ming Lu, Lingjing Chen, Ilwoo Park, Gerd Melkus, Adam Elkhaled, John Kurhanewicz, Lisa Drew, Sebastien Degorce, Michele Mayo, Keith Dillman, Rana …
• Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits.
  International journal of molecular sciences 2018 Krukowski K, Chou A, Feng X, Tiret B, Paladini MS, Riparip LK, Chaumeil MM, Lemere C, Rosi S
• Repeated Mild Head Injury Leads to Wide-Ranging Deficits in Higher-Order Cognitive Functions Associated with the Prefrontal Cortex.
  Journal of neurotrauma 2018 Nolan A, Hennessy E, Krukowski K, Guglielmetti C, Chaumeil MM, Sohal VS, Rosi S
• EXTH-71. HYPERPOLARIZED [1-13C] PYRUVATE AS A BIOMARKER FOR TREATMENT MONITORING IN LYMPHOMA MURINE MODELS.
  Neuro-Oncology 2017 Brice Tiret, Adam Autry, Ilwoo Park, Ming Lu, Rana Anjum, Liza Drew, Sebastien Degorce, Michele Mayo, Keith Dillman, James Rubenstein, Myriam M Chaumeil
• METB-14. DOWN-REGULATION OF ACETATE METABOLISM TOWARDS FATTY ACIDS IN IDH1 MUTANT GLIOMA.
  Neuro-Oncology 2017 Chloe Najac, Marina Radoul, Pavithra Viswanath, Myriam M Chaumeil, Sabrina Ronen
• TMOD-20. EARLY DETECTION OF HDAC INHIBITION IN GLIOBLASTOMA USING ADVANCED HYPERPOLARIZED 13C MRSI.
  Neuro-Oncology 2017 Marina Radoul, Myriam M Chaumeil, Pia Eriksson, Chloe Najac, Pavithra Viswanath, Anne Marie Gillespie, Joydeep Mukherjee, Russell Pieper, Sabrina Ronen
• IMST-04. IMAGING INFLAMMATORY CELL FUNCTION USING 13C MAGNETIC RESONANCE SPECTROSCOPY OF HYPERPOLARIZED 6-13C-LABELED ARGININE.
  Neuro-Oncology 2016 Chloe Najac, Myriam M. Chaumeil, Gary Kohanbash, Caroline Guglielmetti, Jeremy Gordon, Hideho Okada, Sabrina M. Ronen
• Detection of inflammatory cell function using (13)C magnetic resonance spectroscopy of hyperpolarized [6-(13)C]-arginine.
  Scientific reports 2016 Najac C, Chaumeil MM, Kohanbash G, Guglielmetti C, Gordon JW, Okada H, Ronen SM
• Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring.
  NeuroImage. Clinical 2016 Chaumeil MM, Radoul M, Najac C, Eriksson P, Viswanath P, Blough MD, Chesnelong C, Luchman HA, Cairncross JG, Ronen SM
• Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry.
  Tomography (Ann Arbor, Mich.) 2016 Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB
• Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells.
  Frontiers in oncology 2016 Viswanath P, Chaumeil MM, Ronen SM
• MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival.
  Molecular cancer therapeutics 2016 Radoul M, Chaumeil MM, Eriksson P, Wang AS, Phillips JJ, Ronen SM
• CBIO-42DOWN REGULATION OF PYRUVATE DEHYDROGENASE ACTIVITY IS ESSENTIAL FOR CELL PROLIFERATION IN IDH1 MUTANT GLIOMA CELLS.
  Neuro-Oncology 2015 Pavithra Viswanath, Jose L. Izquierdo-Garcia, Pia Eriksson, Larry Cai, Marina Radoul, Myriam M. Chaumeil, Michael Blough, H. Artee Luchmann, Samuel Weiss, J. Gregory Cairncross, Joanna J. Phillips, …
• Magnetic Resonance (MR) Metabolic Imaging in Glioma.
  Brain pathology (Zurich, Switzerland) 2015 Chaumeil MM, Lupo JM, Ronen SM
• IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism.
  Cancer research 2015 Izquierdo-Garcia JL, Viswanath P, Eriksson P, Cai L, Radoul M, Chaumeil MM, Blough M, Luchman HA, Weiss S, Cairncross JG, Phillips JJ, Pieper RO, Ronen SM
• Metabolic reprogramming in mutant IDH1 glioma cells.
  PloS one 2015 Izquierdo-Garcia JL, Viswanath P, Eriksson P, Chaumeil MM, Pieper RO, Phillips JJ, Ronen SM
• BI-07HYPERPOLARIZED [1-13C] GLUTAMATE: A METABOLIC IMAGING BIOMARKER OF IDH1 MUTATIONAL STATUS IN GLIOMA.
  Neuro-Oncology 2014 Myriam Chaumeil, Peder Larson, Sarah Woods, Larry Cai, Pia Eriksson, Aaron Robinson, Janine Lupo, Daniel Vigneron, Sarah Nelson, Russell Pieper, Joanna Phillips, Sabrina Ronen
• TM-0713C MRS DETECTS METABOLIC FLUX ADAPTATION IN IDH MUTANT GLIOMA CELLS.
  Neuro-Oncology 2014 Jose Izquierdo-Garcia, Pia Eriksson, Larry Cai, Myriam Chaumeil, Russell Pieper, Joanna Phillips, Sabrina Ronen
• Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells.
  Cancer research 2014 Park I, Mukherjee J, Ito M, Chaumeil MM, Jalbert LE, Gaensler K, Ronen SM, Nelson SJ, Pieper RO
• Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase.
  PloS one 2014 Izquierdo-Garcia JL, Cai LM, Chaumeil MM, Eriksson P, Robinson AE, Pieper RO, Phillips JJ, Ronen SM
• Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized (13) C metabolites.
  Magnetic resonance in medicine 2014 Koelsch BL, Reed GD, Keshari KR, Chaumeil MM, Bok R, Ronen SM, Vigneron DB, Kurhanewicz J, Larson PEZ
• METABOLIC IMAGING BIOMARKERS FOR MUTANT IDH1 GLIOMAS.
  Neuro-Oncology 2014 Sabrina M. Ronen, Jose L. Izquierdo-Garcia, Myriam M. Chaumeil, Larry M. Cai, Joanna J. Phillips, Russell O. Pieper
• Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma.
  Cancer research 2014 Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM
• Lactate dehydrogenase A silencing in IDH mutant gliomas.
  Neuro-oncology 2013 Chesnelong C, Chaumeil MM, Blough MD, Al-Najjar M, Stechishin OD, Chan JA, Pieper RO, Ronen SM, Weiss S, Luchman HA, Cairncross JG
• METABOLIC PATHWAYS.
  Neuro-Oncology 2013 S. Adams, C. Teo, K. McDonald, A. Zinger, S. Bustamante, C. K. Lim, N. Braidy, B. J. Brew, G. J. Guillemin, S. Agnihotri, K. Burrell, S. Singh, A. Vartanian, A. Wolf, F. Lang, R. Verhaak, C. Hawkins, …
• OMICS AND PROGNSTIC MARKERS.
  Neuro-Oncology 2013 . Adachi, H. Sasaki, S. Nagahisa, K. Yoshida, N. Hattori, Y. Nishiyama, T. Kawase, M. Hasegawa, M. Abe, Y. Hirose, A. Alentorn, Y. Marie, S. Poggioli, H. Alshehhi, B. Boisselier, C. Carpentier, K. …
• Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Jahangiri A, De Lay M, Miller LM, Carbonell WS, Hu YL, Lu K, Tom MW, Paquette J, Tokuyasu TA, Tsao S, Marshall R, Perry A, Bjorgan KM, Chaumeil MM, Ronen SM, Bergers G, Aghi MK
• Non-invasive in vivo assessment of IDH1 mutational status in glioma.
  Nature communications 2013 Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM
• LAB-METABOLIC PATHWAYS.
  Neuro-Oncology 2012 E. Noch, S. Pina-Oviedo, G. Perez-Liz, M. Bookland, L. Del Valle, J. Gordon, K. Khalili, T. A. Juratli, M. Peitzsch, K. Geiger, G. Schackert, G. Eisenhofer, D. Krex, M. M. Chaumeil, S. M. Woods, R. M.…
• Longitudinal evaluation of MPIO-labeled stem cell biodistribution in glioblastoma using high resolution and contrast-enhanced MR imaging at 14.1 tesla.
  Neuro-oncology 2012 Chaumeil MM, Gini B, Yang H, Iwanami A, Sukumar S, Ozawa T, Pieper RO, Mischel PS, James CD, Berger MS, Ronen SM
• pH as a biomarker of neurodegeneration in Huntington's disease: a translational rodent-human MRS study.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012 Chaumeil MM, Valette J, Baligand C, Brouillet E, Hantraye P, Bloch G, Gaura V, Rialland A, Krystkowiak P, Verny C, Damier P, Remy P, Bachoud-Levi AC, Carlier P, Lebon V
• Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma.
  Neuro-oncology 2011 Venkatesh HS, Chaumeil MM, Ward CS, Haas-Kogan DA, James CD, Ronen SM
• ANGIOGENESIS AND INVASION.
  Neuro-Oncology 2011 Y.-L. Hu, M. De Lay, S. D. Rose, W. S. Carbonell, M. K. Aghi, S. D. Rose, W. S. Carbonell, M. De Lay, Y.-L. Hu, J. Paquette, T. Tokuyasu, S. Tsao, M. Chaumeil, S. Ronen, M. K. Aghi, L. A. Matlaf, L. …
• RADIOLOGY.
  Neuro-Oncology 2011 S. Bluml, A. Panigrahy, M. Laskov, G. Dhall, M. D. Nelson, J. L. Finlay, F. H. Gilles, H. Arita, M. Kinoshita, N. Kagawa, Y. Fujimoto, N. Hashimoto, T. Yoshimine, M. Kinoshita, H. Arita, N. Kagawa, Y.…
• Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma.
  NeuroImage 2011 Chaumeil MM, Ozawa T, Park I, Scott K, James CD, Nelson SJ, Ronen SM
• Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy.
  Cancer research 2010 Ward CS, Venkatesh HS, Chaumeil MM, Brandes AH, Vancriekinge M, Dafni H, Sukumar S, Nelson SJ, Vigneron DB, Kurhanewicz J, James CD, Haas-Kogan DA, Ronen SM
• Multimodal neuroimaging provides a highly consistent picture of energy metabolism, validating 31P MRS for measuring brain ATP synthesis.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Chaumeil MM, Valette J, Guillermier M, Brouillet E, Boumezbeur F, Herard AS, Bloch G, Hantraye P, Lebon V
• Diffusion-weighted NMR spectroscopy allows probing of 13C labeling of glutamate inside distinct metabolic compartments in the brain.
  Magnetic resonance in medicine 2008 Valette J, Chaumeil M, Guillermier M, Bloch G, Hantraye P, Lebon V
• Detecting fluorescent protein expression and co-localisation on single secretory vesicles with linear spectral unmixing.
  European biophysics journal : EBJ 2006 Nadrigny F, Rivals I, Hirrlinger PG, Koulakoff A, Personnaz L, Vernet M, Allioux M, Chaumeil M, Ropert N, Giaume C, Kirchhoff F, Oheim M