Morton Cowan, MD
Professor
Pediatrics
School of Medicine
Current Non-NIH Awards:
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TR3-05535 Cowan (PI) 11/01/2012-10/31/2015 California Institute of Regenerative Medicine vGene Correction of Autologous Hematopoietic Stem Cells in Artemis Deficient SCID Goal is to complete the preclinical testing necessary for a clinical gene therapy trial in children with Artemis-SCID. The focus is on optimizing non-chemotherapy approaches to opening marrow niches, studying potential genotoxicity, and demonstrating that gene transduced Artemis deficient hematopoietic stem cells mature in vitro and in vivo into T and B cells. Role: PI
DR2A-05365 Shizuru (PI) 07/01/2013-06/30/2017 California Institute of Regenerative Medicine vA monoclonal antibody that depletes blood stem cells and enables chemotherapy free transplants Goal is to bring to a clinical trial a monoclonal antibody that targets hematopoietic stem cells. The antibody will be evaluated in a non-human primate model followed by a prospective phase I/II clinical trial in children with SCID. Role: Co-PI
Overview: I am a pediatric immunologist, Professor of Pediatrics and Chief, Allergy Immunology and BMT Division at UCSF. I led the planning for what ultimately became the Primary Immune Deficiency Treatment Consortium (PIDTC), an NIH-funded group of 43 centers in the US and Canada focused on PID in which I am the PI and UCSF is the lead institution since 2009. I am on the Steering and Executive Committees of the Pediatric Blood and Marrow Transplant Consortium (PBMTC) and established and led for three years the Pediatric Special Interest Group within the American Society of Blood and Marrow Transplantation. My career has focused on children with PID, with over 180 peer-reviewed publications. My major research interests include SCID in Athabascan-speaking Native Americans (SCIDA), gene therapy for children with Artemis-deficient SCID, non-chemotherapy approaches to opening marrow niches, and the use of haploidentical donors and reduced-toxicity transplantation for childhood diseases. I performed one of the initial haplocompatible T cell depleted marrow transplants for SCID in North America in 1982 and reported one of the first in utero transplants in the world, the first patient with multiple biotin-dependent carboxylase deficiencies and immune deficiency, and the first children with HIV infection. I have treated the largest cohort of children with SCIDA and the largest number of babies diagnosed through newborn screening with SCID in North America, mapped the genetic locus of the gene for SCIDA and radiation sensitive SCID (RS-SCID), and identified the mutation in DCLRE1C responsible for SCIDA in Navajo and Apache children. I designed and completed one of the few prospective single institution trials of haplocompatible HCT for children with SCID and initiated and completed the first large study of children with SCID transplanted in North America and reported by the PIDTC.
Awards
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- Lifetime Achievement Award, Pediatric Blood and Marrow Transplant Consortium, 2019
Education & Training
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- Fellowship Immunology/Allergy/Rheumatology University of California, San Francisco 1979
- Residency Pediatrics University of California, San Francisco 1977
- Residency Surgery Duke University 1972
- M.D. School of Medicine University of Pennsylvania 1970
- B.S. Massachusetts Institute of Technology 1966
Interests
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- hematopoietic cell transplant biology
- primary immune deficiency
- primary immunodeficiency
- transplantation
- gene therapy
- immunology
Websites
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- Profile at UCSF Cancer Center (cancer.ucsf.edu)
- Clinical Profile at UCSF Benioff Children's Hospital (ucsfbenioffchildrens.org)
Grants and Projects
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- Primary Immune Deficiency Treatment Consortium, NIH, 2009-2024
- Gene Transfer for Artemis-Deficient Severe Combined Immunodeficiency Using a Lentiviral Vector to Transduce Autologous CD34 Hematopoietic Stem Cells, California Institute of Regenerative Medicine, 2018-2023
- Lentiviral Gene Therapy for Infants with X-linked Severe Combined Immunodeficiency using Autologous Bone Marrow Stem Cells and Busulfan Conditioning, California Institute of Regenerative Medicine, 2017-2022
- Annual Primary Immune Deficiency Treatment Consortium (PIDTC) Workshop and Education Day, NIH, 2011-2021
- Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
- California National Primate Research Center, NIH, 1975-2015
- General Clinical Research Center, NIH, 1974-2009
- Pediatric Clinical Research Center, NIH, 1981-2007
- Tolerance post in utero transplantation, NIH, 1998-2006
- Gene Linkage Study of Immunodeficiency in Navajo Indians, NIH, 1993-2003
- Induction of Tolerance in Marrow Transplantation, NIH, 1990-1995
- Hiv Infection in Children of Iv Drug Abusing Women, NIH, 1986-1993
Publications (269)
Top publication keywords:
Genetic TherapySevere Combined ImmunodeficiencyGraft vs Host DiseaseTransplantation ChimeraT-LymphocytesBusulfanEndonucleasesImmunologic Deficiency SyndromesUnrelated DonorsWiskott-Aldrich SyndromeNuclear ProteinsGranulomatous Disease, ChronicBone Marrow TransplantationTransplantation ConditioningHematopoietic Stem Cell Transplantation
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Relevance of lymphocyte proliferation to PHA in severe combined immunodeficiency (SCID) and T cell lymphopenia.
Clinical immunology (Orlando, Fla.) 2024 Abraham RS, Basu A, Heimall JR, Dunn E, Yip A, Kapadia M, Kapoor N, Satter LF, Buckley R, O'Reilly R, Cuvelier GDE, Chandra S, Bednarski J, Chaudhury S, Moore TB, Haines H, Dávila Saldaña BJ, … -
Allogeneic hematopoietic cell transplantation is effective for p47phox chronic granulomatous disease: A Primary Immune Deficiency Treatment Consortium study.
The Journal of allergy and clinical immunology 2024 Grunebaum E, Arnold DE, Logan B, Parikh S, Marsh RA, Griffith LM, Mallhi K, Chellapandian D, Lim SS, Deal CL, Kapoor N, Murguía-Favela L, Falcone EL, Prasad VK, Touzot F, Bleesing JJ, Chandrakasan S, … -
Genotype, oxidase status, and preceding infection or autoinflammation do not affect allogeneic HCT outcomes for CGD.
Blood 2023 Leiding JW, Arnold DE, Parikh S, Logan B, Marsh RA, Griffith LM, Wu R, Kidd S, Mallhi K, Chellapandian D, Si Lim SJ, Grunebaum E, Falcone EL, Murguia-Favela L, Grossman D, Prasad VK, Heimall JR, … -
Integrome signatures of lentiviral gene therapy for SCID-X1 patients.
Science advances 2023 Yan KK, Condori J, Ma Z, Metais JY, Ju B, Ding L, Dhungana Y, Palmer LE, Langfitt DM, Ferrara F, Throm R, Shi H, Risch I, Bhatara S, Shaner B, Lockey TD, Talleur AC, Easton J, Meagher MM, Puck JM, … -
Posttransplantation late complications increase over time for patients with SCID: A Primary Immune Deficiency Treatment Consortium (PIDTC) landmark study.
The Journal of allergy and clinical immunology 2023 Eissa H, Thakar MS, Shah AJ, Logan BR, Griffith LM, Dong H, Parrott RE, O'Reilly RJ, Dara J, Kapoor N, Forbes Satter L, Chandra S, Kapadia M, Chandrakasan S, Knutsen A, Jyonouchi SC, Molinari L, Rayes…
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Intestinal microbiome and metabolome signatures in patients with chronic granulomatous disease.
The Journal of allergy and clinical immunology 2023 Chandrasekaran P, Han Y, Zerbe CS, Heller T, DeRavin SS, Kreuzberg SA, Marciano BE, Siu Y, Jones DR, Abraham RS, Stephens MC, Tsou AM, Snapper S, Conlan S, Subramanian P, Quinones M, Grou C, Calderon … -
Measuring the effect of newborn screening on survival after haematopoietic cell transplantation for severe combined immunodeficiency: a 36-year longitudinal study from the Primary Immune Deficiency Treatment Consortium.
Lancet (London, England) 2023 Thakar MS, Logan BR, Puck JM, Dunn EA, Buckley RH, Cowan MJ, O'Reilly RJ, Kapoor N, Satter LF, Pai SY, Heimall J, Chandra S, Ebens CL, Chellapandian D, Williams O, Burroughs LM, Saldana BD, Rayes A, … -
Hypomorphic RAG deficiency: impact of disease burden on survival and thymic recovery argues for early diagnosis and HSCT.
Blood 2023 Schuetz C, Gerke J, Ege M, Walter J, Kusters M, Worth A, Kanakry JA, Dimitrova D, Wolska-Kusnierz B, Chen K, Unal E, Karakukcu M, Pashchenko O, Leiding J, Kawai T, Amrolia PJ, Berghuis D, Buechner J, … -
Successful TCRαβ/CD19-Depleted Hematopoietic Cell Transplantation for a Patient With Artemis Deficiency.
Journal of pediatric hematology/oncology 2023 Tomomasa D, Isoda T, Mitsuiki N, Inoue K, Nishimura A, Uda K, Uchiyama T, Yamashita M, Kamiya T, Endo A, Takagi M, Imai K, Kajiwara M, Cowan MJ, Morio T, Kanegane H -
Lentiviral Gene Therapy for Artemis-Deficient SCID.
The New England journal of medicine 2022 Cowan MJ, Yu J, Facchino J, Fraser-Browne C, Sanford U, Kawahara M, Dara J, Long-Boyle J, Oh J, Chan W, Chag S, Broderick L, Chellapandian D, Decaluwe H, Golski C, Hu D, Kuo CY, Miller HK, Petrovic A,… -
Impact of Genetic Diagnosis on the Outcome of Hematopoietic Stem Cell Transplant in Primary Immunodeficiency Disorders.
Journal of clinical immunology 2022 Forlanini F, Chan A, Dara J, Dvorak CC, Cowan MJ, Puck JM, Dorsey MJ -
The diagnosis of severe combined immunodeficiency (SCID): The Primary Immune Deficiency Treatment Consortium (PIDTC) 2022 Definitions.
The Journal of allergy and clinical immunology 2022 Dvorak CC, Haddad E, Heimall J, Dunn E, Buckley RH, Kohn DB, Cowan MJ, Pai SY, Griffith LM, Cuvelier GDE, Eissa H, Shah AJ, O'Reilly RJ, Pulsipher MA, Wright NAM, Abraham RS, Satter LF, Notarangelo LD… -
The diagnosis of severe combined immunodeficiency: Implementation of the PIDTC 2022 Definitions.
The Journal of allergy and clinical immunology 2022 Dvorak CC, Haddad E, Heimall J, Dunn E, Cowan MJ, Pai SY, Kapoor N, Satter LF, Buckley RH, O'Reilly RJ, Chandra S, Bednarski JJ, Williams O, Rayes A, Moore TB, Ebens CL, Davila Saldana BJ, Petrovic A,… -
Clinical and Genetic Characterization of Patients with Artemis Deficiency in Japan.
Journal of clinical immunology 2022 Inoue K, Miyamoto S, Tomomasa D, Adachi E, Azumi S, Horikoshi Y, Ishihara T, Osone S, Kawahara Y, Kudo K, Kato Z, Ohnishi H, Kashimada K, Imai K, Ohara O, van Zelm MC, Cowan MJ, Morio T, Kanegane H -
Outcomes following treatment for ADA-deficient severe combined immunodeficiency: a report from the PIDTC.
Blood 2022 Cuvelier GDE, Logan BR, Prockop SE, Buckley RH, Kuo CY, Griffith LM, Liu X, Yip A, Hershfield MS, Ayoub PG, Moore TB, Dorsey MJ, O'Reilly RJ, Kapoor N, Pai SY, Kapadia M, Ebens CL, Forbes Satter LR, … -
Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation.
The Journal of allergy and clinical immunology 2022 Labrosse R, Boufaied I, Bourdin B, Gona S, Randolph HE, Logan BR, Bourbonnais S, Berthe C, Chan W, Buckley RH, Parrott RE, Cuvelier GDE, Kapoor N, Chandra S, Dávila Saldaña BJ, Eissa H, Goldman FD, … -
Lentivector cryptic splicing mediates increase in CD34+ clones expressing truncated HMGA2 in human X-linked severe combined immunodeficiency.
Nature communications 2022 De Ravin SS, Liu S, Sweeney CL, Brault J, Whiting-Theobald N, Ma M, Liu T, Choi U, Lee J, O'Brien SA, Quackenbush P, Estwick T, Karra A, Docking E, Kwatemaa N, Guo S, Su L, Sun Z, Zhou S, Puck J, … -
Granulocyte Transfusions in Patients with Chronic Granulomatous Disease Undergoing Hematopoietic Cell Transplantation or Gene Therapy.
Journal of clinical immunology 2022 Arnold DE, Chellapandian D, Parikh S, Mallhi K, Marsh RA, Heimall JR, Grossman D, Chitty-Lopez M, Murguia-Favela L, Gennery AR, Boulad F, Arbuckle E, Cowan MJ, Dvorak CC, Griffith LM, Haddad E, Kohn … -
Association Between the Magnitude of Intravenous Busulfan Exposure and Development of Hepatic Veno-Occlusive Disease in Children and Young Adults Undergoing Myeloablative Allogeneic Hematopoietic Cell Transplantation.
Transplantation and cellular therapy 2022 Bognàr T, Bartelink IH, Egberts TCG, Rademaker CMA, Versluys AB, Slatter MA, Kletzel M, Nath CE, Cuvelier GDE, Savic RM, Dvorak C, Long-Boyle JR, Cowan MJ, Bittencourt H, Bredius RGM, Güngör T, Shaw … -
Quantitative brain MRI morphology in severe and attenuated forms of mucopolysaccharidosis type I.
Molecular genetics and metabolism 2022 Kovac V, Shapiro EG, Rudser KD, Mueller BA, Eisengart JB, Delaney KA, Ahmed A, King KE, Yund BD, Cowan MJ, Raiman J, Mamak EG, Harmatz PR, Shankar SP, Ali N, Cagle SR, Wozniak JR, Lim KO, Orchard PJ, … -
Poor T-cell receptor β repertoire diversity early posttransplant for severe combined immunodeficiency predicts failure of immune reconstitution.
The Journal of allergy and clinical immunology 2021 Delmonte OM, Castagnoli R, Yu J, Dvorak CC, Cowan MJ, Dávila Saldaña BJ, De Ravin SS, Mamcarz E, Chang CK, Daley SR, Griffith LM, Notarangelo LD, Puck JM -
Expectations and experience: Parent and patient perspectives regarding treatment for Severe Combined Immunodeficiency (SCID).
Clinical immunology (Orlando, Fla.) 2021 Smith H, Scalchunes C, Cowan MJ, Puck J, Heimall J -
Correction to: Infections in Infants with SCID: Isolation, Infection Screening and Prophylaxis in PIDTC Centers.
Journal of clinical immunology 2021 Dorsey M, Wright NAM, Chaimowitz NS, Dávila Saldaña BJ, Miller H, Keller MD, Thakar MS, Shah AJ, Abu-Arja R, Andolina J, Aquino V, Barnum JL, Bednarski JJ, Bhatia M, Bonilla FA, Butte MJ, Bunin NJ, … -
The Relationship Between Busulfan Exposure and Achievement of Sustained Donor Myeloid Chimerism in Patients with Non-Malignant Disorders.
Transplantation and cellular therapy 2020 Apsel Winger B, Shukla P, Kharbanda S, Keizer RJ, Goswami S, Cowan MJ, Dvorak CC, Long-Boyle J -
Unknown cytomegalovirus serostatus in primary immunodeficiency disorders: A new category of transplant recipients.
Transplant infectious disease : an official journal of the Transplantation Society 2020 Forlanini F, Dara J, Dvorak CC, Cowan MJ, Puck JM, Dorsey MJ -
Correction: Chronic Granulomatous Disease-Associated IBD Resolves and Does Not Adversely Impact Survival Following Allogeneic HCT.
Journal of clinical immunology 2020 Marsh RA, Leiding JW, Logan BR, Griffith LM, Arnold DE, Haddad E, Falcone EL, Yin Z, Patel K, Arbuckle E, Bleesing JJ, Sullivan KE, Heimall J, Burroughs LM, Skoda-Smith S, Chandrakasan S, Yu LC, … -
Infections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers.
Journal of clinical immunology 2020 Dorsey MJ, Wright NAM, Chaimowitz NS, Dávila Saldaña BJ, Miller H, Keller MD, Thakar MS, Shah AJ, Abu-Arja R, Andolina J, Aquino V, Barnum JL, Bednarski JJ, Bhatia M, Bonilla FA, Butte MJ, Bunin NJ, … -
Successful SCID gene therapy in infant with disseminated BCG.
The journal of allergy and clinical immunology. In practice 2020 Maron G, Kaste S, Bahrami A, Neel M, Malech HL, Puck JM, Cowan MJ, Gottschalk S, Mamcarz E -
Adenosine Deaminase (ADA)-Deficient Severe Combined Immune Deficiency (SCID) in the US Immunodeficiency Network (USIDNet) Registry.
Journal of clinical immunology 2020 Kuo CY, Garabedian E, Puck J, Cowan MJ, Sullivan KE, Buckley RH, Cunningham-Rundles C, Marsh R, Candotti F, Kohn DB -
Reduced Toxicity Conditioning for Nonmalignant Hematopoietic Cell Transplants.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2020 Contreras CF, Long-Boyle JR, Shimano KA, Melton A, Kharbanda S, Dara J, Higham C, Huang JN, Cowan MJ, Dvorak CC -
Excellent outcomes following hematopoietic cell transplantation for Wiskott-Aldrich syndrome: a PIDTC report.
Blood 2020 Burroughs LM, Petrovic A, Brazauskas R, Liu X, Griffith LM, Ochs HD, Bleesing JJ, Edwards S, Dvorak CC, Chaudhury S, Prockop SE, Quinones R, Goldman FD, Quigg TC, Chandrakasan S, Smith AR, Parikh S, … -
Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey.
Frontiers in immunology 2020 Chan AY, Leiding JW, Liu X, Logan BR, Burroughs LM, Allenspach EJ, Skoda-Smith S, Uzel G, Notarangelo LD, Slatter M, Gennery AR, Smith AR, Pai SY, Jordan MB, Marsh RA, Cowan MJ, Dvorak CC, Craddock JA… -
Extended Follow-up After Hematopoietic Cell Transplantation for IκBα Deficiency with Disseminated Mycobacterium avium Infection.
Journal of clinical immunology 2019 Seghezzo SP, Dvorak CC, Cowan MJ, Puck JM, Dorsey MJ -
Quality of Life of Patients with Wiskott Aldrich Syndrome and X-Linked Thrombocytopenia: a Study of the Primary Immune Deficiency Consortium (PIDTC), Immune Deficiency Foundation, and the Wiskott-Aldrich Foundation.
Journal of clinical immunology 2019 Shah AJ, Sokolic R, Logan B, Yin Z, Iyengar S, Scalchunes C, Mangurian C, Albert M, Cowan MJ -
Chronic Granulomatous Disease-Associated IBD Resolves and Does Not Adversely Impact Survival Following Allogeneic HCT.
Journal of clinical immunology 2019 Marsh RA, Leiding JW, Logan BR, Griffith LM, Arnold DE, Haddad E, Falcone EL, Yin Z, Patel K, Arbuckle E, Bleesing JJ, Sullivan KE, Heimall J, Burroughs LM, Skoda-Smith S, Chandrakasan S, Yu LC, … -
Psychosocial services for primary immunodeficiency disorder families during hematopoietic cell transplantation: A descriptive study.
Palliative & supportive care 2019 Mangurian C, Scalchunes C, Yoo J, Logan B, Henderson T, Iyengar S, Smith H, Cowan MJ -
Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.
The New England journal of medicine 2019 Mamcarz E, Zhou S, Lockey T, Abdelsamed H, Cross SJ, Kang G, Ma Z, Condori J, Dowdy J, Triplett B, Li C, Maron G, Aldave Becerra JC, Church JA, Dokmeci E, Love JT, da Matta Ain AC, van der Watt H, … -
Low Exposure Busulfan Conditioning to Achieve Sufficient Multilineage Chimerism in Patients with Severe Combined Immunodeficiency.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2019 Dvorak CC, Long-Boyle J, Dara J, Melton A, Shimano KA, Huang JN, Puck JM, Dorsey MJ, Facchino J, Chang CK, Cowan MJ -
Newborn Screening for Severe Combined Immunodeficiency and T-cell Lymphopenia in California, 2010-2017.
Pediatrics 2019 Amatuni GS, Currier RJ, Church JA, Bishop T, Grimbacher E, Nguyen AA, Agarwal-Hashmi R, Aznar CP, Butte MJ, Cowan MJ, Dorsey MJ, Dvorak CC, Kapoor N, Kohn DB, Markert ML, Moore TB, Naides SJ, … -
Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study.
The Journal of allergy and clinical immunology 2019 Ferrua F, Galimberti S, Courteille V, Slatter MA, Booth C, Moshous D, Neven B, Blanche S, Cavazzana M, Laberko A, Shcherbina A, Balashov D, Soncini E, Porta F, Al-Mousa H, Al-Saud B, Al-Dhekri H, … -
Supporting caregivers during hematopoietic cell transplantation for children with primary immunodeficiency disorders.
The Journal of allergy and clinical immunology 2018 Yoo J, Halley MC, Lown EA, Yank V, Ort K, Cowan MJ, Dorsey MJ, Smith H, Iyengar S, Scalchunes C, Mangurian C -
The genetic landscape of severe combined immunodeficiency in the United States and Canada in the current era (2010-2018).
The Journal of allergy and clinical immunology 2018 Dvorak CC, Haddad E, Buckley RH, Cowan MJ, Logan B, Griffith LM, Kohn DB, Pai SY, Notarangelo L, Shearer W, Prockop S, Kapoor N, Heimall J, Chaudhury S, Shyr D, Chandra S, Cuvelier G, Moore T, Shenoy … -
Advances and highlights in primary immunodeficiencies in 2017.
The Journal of allergy and clinical immunology 2018 Chinen J, Cowan MJ -
SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery.
Blood 2018 Haddad E, Logan BR, Griffith LM, Buckley RH, Parrott RE, Prockop SE, Small TN, Chaisson J, Dvorak CC, Murnane M, Kapoor N, Abdel-Azim H, Hanson IC, Martinez C, Bleesing JJH, Chandra S, Smith AR, … -
Application of a radiosensitivity flow assay in a patient with DNA ligase 4 deficiency.
Blood advances 2018 Buchbinder D, Smith MJ, Kawahara M, Cowan MJ, Buzby JS, Abraham RS -
Allograft and patient survival after sequential HSCT and kidney transplantation from the same donor-A multicenter analysis.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2018 Eder M, Schwarz C, Kammer M, Jacobsen N, Stavroula ML, Cowan MJ, Chongkrairatanakul T, Gaston R, Ravanan R, Ishida H, Bachmann A, Alvarez S, Koch M, Garrouste C, Duffner UA, Cullis B, Schaap N, … -
Outcome of domino hematopoietic stem cell transplantation in human subjects: An international case series.
The Journal of allergy and clinical immunology 2018 Belderbos ME, Gennery AR, Dvorak CC, Blok HJ, Eikema DJ, Silva JMF, Veys P, Neven B, Buckley R, Cole T, Cowan MJ, Goebel WS, Hoenig M, Kuo CY, Stiehm ER, Wynn R, Bierings M, Inborn Errors Working … -
B-cell differentiation and IL-21 response in IL2RG/JAK3 SCID patients after hematopoietic stem cell transplantation.
Blood 2018 Miggelbrink AM, Logan BR, Buckley RH, Parrott RE, Dvorak CC, Kapoor N, Abdel-Azim H, Prockop SE, Shyr D, Decaluwe H, Hanson IC, Gillio A, Dávila Saldaña BJ, Eibel H, Hopkins G, Walter JE, Whangbo JS, … -
Donor lymphocyte infusion and methotrexate for immune recovery after T-cell depleted haploidentical transplantation.
American journal of hematology 2017 Gilman AL, Leung W, Cowan MJ, Cannon M, Epstein S, Barnhart C, Shah K, Hyland M, Fukes T, Ivanova A -
Immune reconstitution and survival of 100 SCID patients post-hematopoietic cell transplant: a PIDTC natural history study.
Blood 2017 Heimall J, Logan BR, Cowan MJ, Notarangelo LD, Griffith LM, Puck JM, Kohn DB, Pulsipher MA, Parikh S, Martinez C, Kapoor N, O'Reilly R, Boyer M, Pai SY, Goldman F, Burroughs L, Chandra S, Kletzel M, … -
Corrigendum: Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Content.
Frontiers in immunology 2017 Dobbs K, Tabellini G, Calzoni E, Patrizi O, Martinez P, Giliani SC, Moratto D, Al-Herz W, Cancrini C, Cowan M, Bleesing J, Booth C, Buchbinder D, Burns SO, Chatila TA, Chou J, Daza-Cajigal V, Ott de … -
Long term outcomes of severe combined immunodeficiency: therapy implications.
Expert review of clinical immunology 2017 Heimall J, Cowan MJ -
Neurologic event-free survival demonstrates a benefit for SCID patients diagnosed by newborn screening.
Blood advances 2017 Dvorak CC, Puck JM, Wahlstrom JT, Dorsey M, Melton A, Cowan MJ -
Opening Marrow Niches in Patients Undergoing Autologous Hematopoietic Stem Cell Gene Therapy.
Hematology/oncology clinics of North America 2017 Cowan MJ, Dvorak CC, Long-Boyle J -
Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Content.
Frontiers in immunology 2017 Dobbs K, Tabellini G, Calzoni E, Patrizi O, Martinez P, Giliani SC, Moratto D, Al-Herz W, Cancrini C, Cowan M, Bleesing J, Booth C, Buchbinder D, Burns SO, Chatila TA, Chou J, Daza-Cajigal V, Ott de … -
Pharmacokinetics and Model-Based Dosing to Optimize Fludarabine Therapy in Pediatric Hematopoietic Cell Transplant Recipients.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2017 Ivaturi V, Dvorak CC, Chan D, Liu T, Cowan MJ, Wahlstrom J, Stricherz M, Jennissen C, Orchard PJ, Tolar J, Pai SY, Huang L, Aweeka F, Long-Boyle J -
Recommendations for Screening and Management of Late Effects in Patients with Severe Combined Immunodeficiency after Allogenic Hematopoietic Cell Transplantation: A Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric HCT.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2017 Heimall J, Buckley RH, Puck J, Fleisher TA, Gennery AR, Haddad E, Neven B, Slatter M, Roderick S, Baker KS, Dietz AC, Duncan C, Griffith LM, Notarangelo L, Pulsipher MA, Cowan MJ -
Hematopoietic Stem Cell Transplantation Activity in Pediatric Cancer between 2008 and 2014 in the United States: A Center for International Blood and Marrow Transplant Research Report.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2017 Khandelwal P, Millard HR, Thiel E, Abdel-Azim H, Abraham AA, Auletta JJ, Boulad F, Brown VI, Camitta BM, Chan KW, Chaudhury S, Cowan MJ, Angel-Diaz M, Gadalla SM, Gale RP, Hale G, Kasow KA, Keating AK… -
Unconditioned unrelated donor bone marrow transplantation for IL7Rα- and Artemis-deficient SCID.
Bone marrow transplantation 2017 Dvorak CC, Patel K, Puck JM, Wahlstrom J, Dorsey MJ, Adams R, Facchino J, Cowan MJ -
Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders.
The Journal of allergy and clinical immunology 2017 Slack J, Albert MH, Balashov D, Belohradsky BH, Bertaina A, Bleesing J, Booth C, Buechner J, Buckley RH, Ouachée-Chardin M, Deripapa E, Drabko K, Eapen M, Feuchtinger T, Finocchi A, Gaspar HB, Ghosh S… -
Reticular dysgenesis: international survey on clinical presentation, transplantation, and outcome.
Blood 2017 Hoenig M, Lagresle-Peyrou C, Pannicke U, Notarangelo LD, Porta F, Gennery AR, Slatter M, Cowan MJ, Stepensky P, Al-Mousa H, Al-Zahrani D, Pai SY, Al Herz W, Gaspar HB, Veys P, Oshima K, Imai K, Yabe H… -
Treatment of infants identified as having severe combined immunodeficiency by means of newborn screening.
The Journal of allergy and clinical immunology 2017 Dorsey MJ, Dvorak CC, Cowan MJ, Puck JM -
Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B.
The New England journal of medicine 2016 Punwani D, Zhang Y, Yu J, Cowan MJ, Rana S, Kwan A, Adhikari AN, Lizama CO, Mendelsohn BA, Fahl SP, Chellappan A, Srinivasan R, Brenner SE, Wiest DL, Puck JM -
Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency.
The Journal of clinical investigation 2016 Walter JE, Rosen LB, Csomos K, Rosenberg JM, Mathew D, Keszei M, Ujhazi B, Chen K, Lee YN, Tirosh I, Dobbs K, Al-Herz W, Cowan MJ, Puck J, Bleesing JJ, Grimley MS, Malech H, De Ravin SS, Gennery AR, … -
Devouring the Hematopoietic Stem Cell: Setting the Table for Marrow Cell Transplantation.
Molecular therapy : the journal of the American Society of Gene Therapy 2016 Cowan MJ, Kiem HP -
Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis.
The Lancet. Haematology 2016 Bartelink IH, Lalmohamed A, van Reij EM, Dvorak CC, Savic RM, Zwaveling J, Bredius RG, Egberts AC, Bierings M, Kletzel M, Shaw PJ, Nath CE, Hempel G, Ansari M, Krajinovic M, Théorêt Y, Duval M, Keizer… -
The Second Pediatric Blood and Marrow Transplant Consortium International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation: Defining the Unique Late Effects of Children Undergoing Hematopoietic Cell Transplantation for Immune Deficiencies, Inherited Marrow Failure Disorders, and Hemoglobinopathies.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2016 Dietz AC, Duncan CN, Alter BP, Bresters D, Cowan MJ, Notarangelo L, Rosenberg PS, Shenoy S, Skinner R, Walters MC, Wagner J, Baker KS, Pulsipher MA -
Lentivirus Mediated Correction of Artemis-Deficient Severe Combined Immunodeficiency.
Human gene therapy 2016 Punwani D, Kawahara M, Yu J, Sanford U, Roy S, Patel K, Carbonaro DA, Karlen AD, Khan S, Cornetta K, Rothe M, Schambach A, Kohn DB, Malech HL, McIvor RS, Puck JM, Cowan MJ -
Unrelated Hematopoietic Cell Transplantation in a Patient with Combined Immunodeficiency with Granulomatous Disease and Autoimmunity Secondary to RAG Deficiency.
Journal of clinical immunology 2016 John T, Walter JE, Schuetz C, Chen K, Abraham RS, Bonfim C, Boyce TG, Joshi AY, Kang E, Carvalho BT, Mahajerin A, Nugent D, Puthenveetil G, Soni A, Su H, Cowan MJ, Notarangelo L, Buchbinder D -
The Primary Immune Deficiency Treatment Consortium: how can it improve definitive therapy for PID?
Expert review of clinical immunology 2016 Cowan MJ -
Evaluation of Pre-Hematopoietic Cell Transplantation (HCT) Brain MRI and Neurologic Complications of Pediatric Patients Undergoing HCT for Hematologic Malignancies.
Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses 2016 Bailey-Olson M, Cowan M, Dvorak C, Mueller S, Owens A, Wahlstrom J, Horn B -
Severe, persistent, and fatal T-cell immunodeficiency following therapy for infantile leukemia.
Pediatric blood & cancer 2016 Geerlinks AV, Issekutz T, Wahlstrom JT, Sullivan KE, Cowan MJ, Dvorak CC, Fernandez CV -
Transplacental maternal engraftment and posttransplantation graft-versus-host disease in children with severe combined immunodeficiency.
The Journal of allergy and clinical immunology 2016 Wahlstrom J, Patel K, Eckhert E, Kong D, Horn B, Cowan MJ, Dvorak CC -
Risk of serious bloodstream infections is low in pediatric hematopoietic stem cell transplant (HSCT) recipients with fevers due to antithymocyte globulins and alemtuzumab.
Bone marrow transplantation 2016 Horn B, O'Kane S, Wattier RL, Wahlstrom JT, Melton A, Cowan MJ, Dvorak CC -
Primary Immune Deficiency Treatment Consortium (PIDTC) update.
The Journal of allergy and clinical immunology 2016 Griffith LM, Cowan MJ, Notarangelo LD, Kohn DB, Puck JM, Shearer WT, Burroughs LM, Torgerson TR, Decaluwe H, Haddad E, workshop participants -
Safe and Effective Prophylaxis with Bimonthly Intravenous Pentamidine in the Pediatric Hematopoietic Stem Cell Transplant Population.
The Pediatric infectious disease journal 2016 Levy ER, Musick L, Zinter MS, Lang T, Cowan MJ, Weintrub PS, Dvorak CC -
A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.
The Journal of experimental medicine 2016 Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM -
Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency.
The Journal of clinical investigation 2015 Walter JE, Rosen LB, Csomos K, Rosenberg JM, Mathew D, Keszei M, Ujhazi B, Chen K, Lee YN, Tirosh I, Dobbs K, Al-Herz W, Cowan MJ, Puck J, Bleesing JJ, Grimley MS, Malech H, De Ravin SS, Gennery AR, … -
New Insights Into Multicenter PICU Mortality Among Pediatric Hematopoietic Stem Cell Transplant Patients.
Critical care medicine 2015 Zinter MS, Dvorak CC, Spicer A, Cowan MJ, Sapru A -
Neurocognition across the spectrum of mucopolysaccharidosis type I: Age, severity, and treatment.
Molecular genetics and metabolism 2015 Shapiro EG, Nestrasil I, Rudser K, Delaney K, Kovac V, Ahmed A, Yund B, Orchard PJ, Eisengart J, Niklason GR, Raiman J, Mamak E, Cowan MJ, Bailey-Olson M, Harmatz P, Shankar SP, Cagle S, Ali N, … -
Radiation-sensitive severe combined immunodeficiency: The arguments for and against conditioning before hematopoietic cell transplantation--what to do?
The Journal of allergy and clinical immunology 2015 Cowan MJ, Gennery AR -
Role of transgene regulation in ex vivo lentiviral correction of artemis deficiency.
Human gene therapy 2015 Multhaup MM, Podetz-Pedersen KM, Karlen AD, Olson ER, Gunther R, Somia NV, Blazar BR, Cowan MJ, McIvor RS -
Population pharmacokinetics of busulfan in pediatric and young adult patients undergoing hematopoietic cell transplant: a model-based dosing algorithm for personalized therapy and implementation into routine clinical use.
Therapeutic drug monitoring 2015 Long-Boyle JR, Savic R, Yan S, Bartelink I, Musick L, French D, Law J, Horn B, Cowan MJ, Dvorak CC -
Successful newborn screening for SCID in the Navajo Nation.
Clinical immunology (Orlando, Fla.) 2015 Kwan A, Hu D, Song M, Gomes H, Brown DR, Bourque T, Gonzalez-Espinosa D, Lin Z, Cowan MJ, Puck JM -
Hematopoietic Stem Cell Transplantation for Severe Combined Immunodeficiency.
Current pediatrics reports 2015 Wahlstrom JT, Dvorak CC, Cowan MJ -
Chimerism-based pre-emptive immunotherapy with fast withdrawal of immunosuppression and donor lymphocyte infusions after allogeneic stem cell transplantation for pediatric hematologic malignancies.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2015 Horn B, Petrovic A, Wahlstrom J, Dvorak CC, Kong D, Hwang J, Expose-Spencer J, Gates M, Cowan MJ -
Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation.
Journal of clinical immunology 2015 Punwani D, Wang H, Chan AY, Cowan MJ, Mallott J, Sunderam U, Mollenauer M, Srinivasan R, Brenner SE, Mulder A, Claas FH, Weiss A, Puck JM -
Stem cell transplantation for primary immunodeficiency diseases: the North American experience.
Current opinion in allergy and clinical immunology 2014 Pai SY, Cowan MJ -
Newborn screening for severe combined immunodeficiency in 11 screening programs in the United States.
JAMA 2014 Kwan A, Abraham RS, Currier R, Brower A, Andruszewski K, Abbott JK, Baker M, Ballow M, Bartoshesky LE, Bonilla FA, Brokopp C, Brooks E, Caggana M, Celestin J, Church JA, Comeau AM, Connelly JA, Cowan … -
Comparison of outcomes of hematopoietic stem cell transplantation without chemotherapy conditioning by using matched sibling and unrelated donors for treatment of severe combined immunodeficiency.
The Journal of allergy and clinical immunology 2014 Dvorak CC, Hassan A, Slatter MA, Hönig M, Lankester AC, Buckley RH, Pulsipher MA, Davis JH, Güngör T, Gabriel M, Bleesing JH, Bunin N, Sedlacek P, Connelly JA, Crawford DF, Notarangelo LD, Pai SY, … -
Transplantation outcomes for severe combined immunodeficiency, 2000-2009.
The New England journal of medicine 2014 Pai SY, Logan BR, Griffith LM, Buckley RH, Parrott RE, Dvorak CC, Kapoor N, Hanson IC, Filipovich AH, Jyonouchi S, Sullivan KE, Small TN, Burroughs L, Skoda-Smith S, Haight AE, Grizzle A, Pulsipher MA… -
A trial of alemtuzumab adjunctive therapy in allogeneic hematopoietic cell transplantation with minimal conditioning for severe combined immunodeficiency.
Pediatric transplantation 2014 Dvorak CC, Horn BN, Puck JM, Adams S, Veys P, Czechowicz A, Cowan MJ -
A trial of plerixafor adjunctive therapy in allogeneic hematopoietic cell transplantation with minimal conditioning for severe combined immunodeficiency.
Pediatric transplantation 2014 Dvorak CC, Horn BN, Puck JM, Czechowicz A, Shizuru JA, Ko RM, Cowan MJ -
Combined umbilical cord blood and bone marrow from HLA-identical sibling donors for hematopoietic stem cell transplantation in children with hemoglobinopathies.
Pediatric blood & cancer 2014 Soni S, Boulad F, Cowan MJ, Scaradavou A, Dahake J, Edwards S, Walters MC -
Survey on retransplantation criteria for patients with severe combined immunodeficiency.
The Journal of allergy and clinical immunology 2013 Haddad E, Allakhverdi Z, Griffith LM, Cowan MJ, Notarangelo LD -
Establishing diagnostic criteria for severe combined immunodeficiency disease (SCID), leaky SCID, and Omenn syndrome: the Primary Immune Deficiency Treatment Consortium experience.
The Journal of allergy and clinical immunology 2013 Shearer WT, Dunn E, Notarangelo LD, Dvorak CC, Puck JM, Logan BR, Griffith LM, Kohn DB, O'Reilly RJ, Fleisher TA, Pai SY, Martinez CA, Buckley RH, Cowan MJ -
SCID patients with ARTEMIS vs RAG deficiencies following HCT: increased risk of late toxicity in ARTEMIS-deficient SCID.
Blood 2013 Schuetz C, Neven B, Dvorak CC, Leroy S, Ege MJ, Pannicke U, Schwarz K, Schulz AS, Hoenig M, Sparber-Sauer M, Gatz SA, Denzer C, Blanche S, Moshous D, Picard C, Horn BN, de Villartay JP, Cavazzana M, … -
Primary Immune Deficiency Treatment Consortium (PIDTC) report.
The Journal of allergy and clinical immunology 2013 Griffith LM, Cowan MJ, Notarangelo LD, Kohn DB, Puck JM, Pai SY, Ballard B, Bauer SC, Bleesing JJ, Boyle M, Brower A, Buckley RH, van der Burg M, Burroughs LM, Candotti F, Cant AJ, Chatila T, … -
Effect of weight and maturation on busulfan clearance in infants and small children undergoing hematopoietic cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2013 Savic RM, Cowan MJ, Dvorak CC, Pai SY, Pereira L, Bartelink IH, Boelens JJ, Bredius RG, Wynn RF, Cuvelier GD, Shaw PJ, Slatter MA, Long-Boyle J -
The missing vital sign.
BMJ (Clinical research ed.) 2013 Mangurian C, Cowan MJ -
The natural history of children with severe combined immunodeficiency: baseline features of the first fifty patients of the primary immune deficiency treatment consortium prospective study 6901.
Journal of clinical immunology 2013 Dvorak CC, Cowan MJ, Logan BR, Notarangelo LD, Griffith LM, Puck JM, Kohn DB, Shearer WT, O'Reilly RJ, Fleisher TA, Pai SY, Hanson IC, Pulsipher MA, Fuleihan R, Filipovich A, Goldman F, Kapoor N, … -
Newborn screening for severe combined immunodeficiency and T-cell lymphopenia in California: results of the first 2 years.
The Journal of allergy and clinical immunology 2013 Kwan A, Church JA, Cowan MJ, Agarwal R, Kapoor N, Kohn DB, Lewis DB, McGhee SA, Moore TB, Stiehm ER, Porteus M, Aznar CP, Currier R, Lorey F, Puck JM -
A 32-Year-Old Female with AIDS, Pneumocystis jiroveci Pneumonia, and Methemoglobinemia.
Case reports in critical care 2013 Giangreco GJ, Campbell D, Cowan MJ -
Unresolved issues in hematopoietic stem cell transplantation for severe combined immunodeficiency: need for safer conditioning and reduced late effects.
The Journal of allergy and clinical immunology 2013 Horn B, Cowan MJ -
The global cardiovascular risk transition: associations of four metabolic risk factors with national income, urbanization, and Western diet in 1980 and 2008.
Circulation 2013 Danaei G, Singh GM, Paciorek CJ, Lin JK, Cowan MJ, Finucane MM, Farzadfar F, Stevens GA, Riley LM, Lu Y, Rao M, Ezzati M, Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating … -
Inequalities in non-communicable diseases and effective responses.
Lancet (London, England) 2013 Di Cesare M, Khang YH, Asaria P, Blakely T, Cowan MJ, Farzadfar F, Guerrero R, Ikeda N, Kyobutungi C, Msyamboza KP, Oum S, Lynch JW, Marmot MG, Ezzati M, Lancet NCD Action Group -
Haploidentical related-donor hematopoietic cell transplantation in children using megadoses of CliniMACs-selected CD34(+) cells and a fixed CD3(+) dose.
Bone marrow transplantation 2012 Dvorak CC, Gilman AL, Horn B, Oon CY, Dunn EA, Baxter-Lowe LA, Cowan MJ -
Nonpharmacologic approach to minimizing shivering during surface cooling: a proof of principle study.
Journal of critical care 2012 Shah NG, Cowan MJ, Pickering E, Sareh H, Afshar M, Fox D, Marron J, Davis J, Herold K, Shanholtz CB, Hasday JD -
Busulfan, fludarabine, and alemtuzumab as a reduced toxicity regimen for children with malignant and nonmalignant diseases improves engraftment and graft-versus-host disease without delaying immune reconstitution.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012 Law J, Cowan MJ, Dvorak CC, Musick L, Long-Boyle JR, Baxter-Lowe LA, Horn B -
Adoptive immunotherapy with CMV-specific cytotoxic T lymphocytes for stem cell transplant patients with refractory CMV infections.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2012 Bao L, Cowan MJ, Dunham K, Horn B, McGuirk J, Gilman A, Lucas KG -
Long-term survival and late deaths after hematopoietic cell transplantation for primary immunodeficiency diseases and inborn errors of metabolism.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012 Eapen M, Ahn KW, Orchard PJ, Cowan MJ, Davies SM, Fasth A, Hassebroek A, Ayas M, Bonfim C, O'Brien TA, Gross TG, Horwitz M, Horwitz E, Kapoor N, Kurtzberg J, Majhail N, Ringden O, Szabolcs P, Veys P, … -
Massage for children undergoing hematopoietic cell transplantation: a qualitative report.
Evidence-based complementary and alternative medicine : eCAM 2012 Ackerman SL, Lown EA, Dvorak CC, Dunn EA, Abrams DI, Horn BN, Degelman M, Cowan MJ, Mehling WE -
Hematopoietic cell transplant and use of massage for improved symptom management: results from a pilot randomized control trial.
Evidence-based complementary and alternative medicine : eCAM 2012 Mehling WE, Lown EA, Dvorak CC, Cowan MJ, Horn BN, Dunn EA, Acree M, Abrams DI, Hecht FM -
IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo.
Blood 2011 Recher M, Berglund LJ, Avery DT, Cowan MJ, Gennery AR, Smart J, Peake J, Wong M, Pai SY, Baxi S, Walter JE, Palendira U, Tangye GA, Rice M, Brothers S, Al-Herz W, Oettgen H, Eibel H, Puck JM, Cattaneo… -
T cell and B Cell immunity can be reconstituted with mismatched hematopoietic stem cell transplantation without alkylator therapy in artemis-deficient mice using anti-natural killer cell antibody and photochemically treated sensitized donor T cells.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2011 Xiao TZ, Singh K, Dunn E, Ramachandran R, Cowan MJ -
Genotype, phenotype, and outcomes of nine patients with T-B+NK+ SCID.
Pediatric transplantation 2011 Yu GP, Nadeau KC, Berk DR, de Saint Basile G, Lambert N, Knapnougel P, Roberts J, Kavanau K, Dunn E, Stiehm ER, Lewis DB, Umetsu DT, Puck JM, Cowan MJ -
Hematopoietic stem cell transplantation for CD3δ deficiency.
The Journal of allergy and clinical immunology 2011 Marcus N, Takada H, Law J, Cowan MJ, Gil J, Regueiro JR, Plaza Lopez de Sabando D, Lopez-Granados E, Dalal J, Friedrich W, Manfred H, Hanson IC, Grunebaum E, Shearer WT, Roifman CM -
Physical activity in 22 African countries: results from the World Health Organization STEPwise approach to chronic disease risk factor surveillance.
American journal of preventive medicine 2011 Guthold R, Louazani SA, Riley LM, Cowan MJ, Bovet P, Damasceno A, Sambo BH, Tesfaye F, Armstrong TP -
National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants.
Lancet (London, England) 2011 Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, Lin JK, Farzadfar F, Khang YH, Stevens GA, Rao M, Ali MK, Riley LM, Robinson CA, Ezzati M, Global Burden of Metabolic Risk Factors of … -
Characterization of the human artemis promoter by heterologous gene expression in vitro and in vivo.
DNA and cell biology 2011 Multhaup MM, Gurram S, Podetz-Pedersen KM, Karlen AD, Swanson DL, Somia NV, Hackett PB, Cowan MJ, McIvor RS -
Long-term outcome and lineage-specific chimerism in 194 patients with Wiskott-Aldrich syndrome treated by hematopoietic cell transplantation in the period 1980-2009: an international collaborative study.
Blood 2011 Moratto D, Giliani S, Bonfim C, Mazzolari E, Fischer A, Ochs HD, Cant AJ, Thrasher AJ, Cowan MJ, Albert MH, Small T, Pai SY, Haddad E, Lisa A, Hambleton S, Slatter M, Cavazzana-Calvo M, Mahlaoui N, … -
Malignancies after hematopoietic cell transplantation for primary immune deficiencies: a report from the Center for International Blood and Marrow Transplant Research.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2011 Kamani NR, Kumar S, Hassebroek A, Eapen M, LeRademacher J, Casper J, Cowan M, Sánchez de Toledo J, Ferster A, Szabolcs P, Wingard JR, Horwitz E, Filipovich AH -
Allogeneic hematopoietic SCT for alpha-mannosidosis: an analysis of 17 patients.
Bone marrow transplantation 2011 Mynarek M, Tolar J, Albert MH, Escolar ML, Boelens JJ, Cowan MJ, Finnegan N, Glomstein A, Jacobsohn DA, Kühl JS, Yabe H, Kurtzberg J, Malm D, Orchard PJ, Klein C, Lücke T, Sykora KW -
Immunization of hematopoietic stem cell transplant recipients against vaccine-preventable diseases.
Expert review of clinical immunology 2011 Small TN, Cowan MJ -
National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants.
Lancet (London, England) 2011 Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, Singh GM, Gutierrez HR, Lu Y, Bahalim AN, Farzadfar F, Riley LM, Ezzati M, Global Burden of Metabolic Risk Factors of Chronic Diseases… -
National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321 country-years and 3·0 million participants.
Lancet (London, England) 2011 Farzadfar F, Finucane MM, Danaei G, Pelizzari PM, Cowan MJ, Paciorek CJ, Singh GM, Lin JK, Stevens GA, Riley LM, Ezzati M, Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating … -
National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5·4 million participants.
Lancet (London, England) 2011 Danaei G, Finucane MM, Lin JK, Singh GM, Paciorek CJ, Cowan MJ, Farzadfar F, Stevens GA, Lim SS, Riley LM, Ezzati M, Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (… -
Chronic granulomatous disease: lessons from a rare disorder.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2011 Segal BH, Veys P, Malech H, Cowan MJ -
HLA-matched sibling bone marrow transplantation for β-thalassemia major.
Blood 2010 Sabloff M, Chandy M, Wang Z, Logan BR, Ghavamzadeh A, Li CK, Irfan SM, Bredeson CN, Cowan MJ, Gale RP, Hale GA, Horan J, Hongeng S, Eapen M, Walters MC -
X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease.
Blood 2010 Booth C, Gilmour KC, Veys P, Gennery AR, Slatter MA, Chapel H, Heath PT, Steward CG, Smith O, O'Meara A, Kerrigan H, Mahlaoui N, Cavazzana-Calvo M, Fischer A, Moshous D, Blanche S, Pachlopnik Schmid J… -
Cytotoxicity associated with artemis overexpression after lentiviral vector-mediated gene transfer.
Human gene therapy 2010 Multhaup M, Karlen AD, Swanson DL, Wilber A, Somia NV, Cowan MJ, McIvor RS -
Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency.
The Journal of experimental medicine 2010 Walter JE, Rucci F, Patrizi L, Recher M, Regenass S, Paganini T, Keszei M, Pessach I, Lang PA, Poliani PL, Giliani S, Al-Herz W, Cowan MJ, Puck JM, Bleesing J, Niehues T, Schuetz C, Malech H, DeRavin … -
The type I NADH dehydrogenase of Mycobacterium tuberculosis counters phagosomal NOX2 activity to inhibit TNF-alpha-mediated host cell apoptosis.
PLoS pathogens 2010 Miller JL, Velmurugan K, Cowan MJ, Briken V -
Prostaglandin E2 potentiates heat shock-induced heat shock protein 72 expression in A549 cells.
Prostaglandins & other lipid mediators 2010 Shah NG, Tulapurkar ME, Singh IS, Shelhamer JH, Cowan MJ, Hasday JD -
Physical activity and sedentary behavior among schoolchildren: a 34-country comparison.
The Journal of pediatrics 2010 Guthold R, Cowan MJ, Autenrieth CS, Kann L, Riley LM -
Reduced-intensity conditioning regimens for allogeneic transplantation in children with acute lymphoblastic leukemia.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2010 Verneris MR, Eapen M, Duerst R, Carpenter PA, Burke MJ, Afanasyev BV, Cowan MJ, He W, Krance R, Li CK, Tan PL, Wagner JE, Davies SM -
Safety of the live, attenuated varicella vaccine in pediatric recipients of hematopoietic SCTs.
Bone marrow transplantation 2010 Kussmaul SC, Horn BN, Dvorak CC, Abramovitz L, Cowan MJ, Weintrub PS -
Radiosensitive severe combined immunodeficiency disease.
Immunology and allergy clinics of North America 2010 Dvorak CC, Cowan MJ -
Advancement of pediatric blood and marrow transplantation research in North America: priorities of the Pediatric Blood and Marrow Transplant Consortium.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2010 Pulsipher MA, Horwitz EM, Haight AE, Kadota R, Chen AR, Frangoul H, Cooper LJ, Jacobsohn DA, Goyal RK, Mitchell D, Nieder ML, Yanik G, Cowan MJ, Soni S, Gardner S, Shenoy S, Taylor D, Cairo M, Schultz… -
Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
The Journal of allergy and clinical immunology 2009 Griffith LM, Cowan MJ, Notarangelo LD, Puck JM, Buckley RH, Candotti F, Conley ME, Fleisher TA, Gaspar HB, Kohn DB, Ochs HD, O'Reilly RJ, Rizzo JD, Roifman CM, Small TN, Shearer WT, Workshop … -
Development of herpes simplex virus stomatitis during receipt of cidofovir therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009 Dvorak CC, Cowan MJ, Horn B, Weintrub PS -
Clinical and immunologic outcomes following haplocompatible donor lymphocyte infusions.
Bone marrow transplantation 2009 Dvorak CC, Gilman AL, Horn B, Jaroscak J, Dunn EA, Baxter-Lowe LA, Cowan MJ -
Allogeneic hematopoietic cell transplantation for refractory myasthenia gravis.
Archives of neurology 2009 Strober J, Cowan MJ, Horn BN -
Primary graft failure after umbilical cord blood transplant rescued by parental haplocompatible stem cell transplantation.
Journal of pediatric hematology/oncology 2009 Dvorak CC, Gilman AL, Horn B, Cowan MJ -
A non-leaky Artemis-deficient mouse that accurately models the human severe combined immune deficiency phenotype, including resistance to hematopoietic stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009 Xiao Z, Dunn E, Singh K, Khan IS, Yannone SM, Cowan MJ -
Airway management in children with mucopolysaccharidoses.
Archives of otolaryngology--head & neck surgery 2009 Yeung AH, Cowan MJ, Horn B, Rosbe KW -
Infusion of cytomegalovirus specific cytotoxic T lymphocytes from a sero-negative donor can facilitate resolution of infection and immune reconstitution.
The Pediatric infectious disease journal 2009 Horn B, Bao L, Dunham K, Stamer M, Adler S, Cowan M, Lucas K -
Wiskott-Aldrich syndrome: diagnosis, clinical and laboratory manifestations, and treatment.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009 Ochs HD, Filipovich AH, Veys P, Cowan MJ, Kapoor N -
The graft-versus-leukemia effect using matched unrelated donors is not superior to HLA-identical siblings for hematopoietic stem cell transplantation.
Blood 2008 Ringdén O, Pavletic SZ, Anasetti C, Barrett AJ, Wang T, Wang D, Antin JH, Di Bartolomeo P, Bolwell BJ, Bredeson C, Cairo MS, Gale RP, Gupta V, Hahn T, Hale GA, Halter J, Jagasia M, Litzow MR, … -
Allogeneic hematopoietic cell transplantation for primary immune deficiency diseases: current status and critical needs.
The Journal of allergy and clinical immunology 2008 Griffith LM, Cowan MJ, Kohn DB, Notarangelo LD, Puck JM, Schultz KR, Buckley RH, Eapen M, Kamani NR, O'Reilly RJ, Parkman R, Roifman CM, Sullivan KE, Filipovich AH, Fleisher TA, Shearer WT -
Feasibility study of preemptive withdrawal of immunosuppression based on chimerism testing in children undergoing myeloablative allogeneic transplantation for hematologic malignancies.
Bone marrow transplantation 2008 Horn B, Soni S, Khan S, Petrovic A, Breslin N, Cowan M, Pelle-Day G, Cooperstein E, Baxter-Lowe LA -
Megadose CD34(+) cell grafts improve recovery of T cell engraftment but not B cell immunity in patients with severe combined immunodeficiency disease undergoing haplocompatible nonmyeloablative transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2008 Dvorak CC, Hung GY, Horn B, Dunn E, Oon CY, Cowan MJ -
A novel missense RAG-1 mutation results in T-B-NK+ SCID in Athabascan-speaking Dine Indians from the Canadian Northwest Territories.
European journal of human genetics : EJHG 2008 Xiao Z, Yannone SM, Dunn E, Cowan MJ -
Maternal T-cell engraftment associated with severe hemophagocytosis of the bone marrow in untreated X-linked severe combined immunodeficiency.
Journal of pediatric hematology/oncology 2008 Dvorak CC, Sandford A, Fong A, Cowan MJ, George TI, Lewis DB -
Increasing mixed chimerism and the risk of graft loss in children undergoing allogeneic hematopoietic stem cell transplantation for non-malignant disorders.
Bone marrow transplantation 2008 Ozyurek E, Cowan MJ, Koerper MA, Baxter-Lowe LA, Dvorak CC, Horn BN -
Hematopoietic stem cell transplantation for severe combined immunodeficiency diseases.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2008 Cowan MJ, Neven B, Cavazanna-Calvo M, Fischer A, Puck J -
Hematopoietic stem cell transplantation for primary immunodeficiency disease.
Bone marrow transplantation 2007 Dvorak CC, Cowan MJ -
Hematopoietic cell transplantation for Chediak-Higashi syndrome.
Bone marrow transplantation 2007 Eapen M, DeLaat CA, Baker KS, Cairo MS, Cowan MJ, Kurtzberg J, Steward CG, Veys PA, Filipovich AH -
Index of suspicion.
Pediatrics in review 2006 Taylor Z, Butani L, Blumberg D, Cowan M, Wara D, Gopal S, Gavrilita C, Da-Silva S -
Processing of 3'-phosphoglycolate-terminated DNA double strand breaks by Artemis nuclease.
The Journal of biological chemistry 2006 Povirk LF, Zhou T, Zhou R, Cowan MJ, Yannone SM -
Reduced intensity conditioning using intravenous busulfan, fludarabine and rabbit ATG for children with nonmalignant disorders and CML.
Bone marrow transplantation 2006 Horn B, Baxter-Lowe LA, Englert L, McMillan A, Quinn M, Desantes K, Cowan M -
Two-tiered universal newborn screening strategy for severe combined immunodeficiency.
Molecular genetics and metabolism 2005 McGhee SA, Stiehm ER, Cowan M, Krogstad P, McCabe ER -
B7.2-/- mature dendritic cells generate T-helper 2 and regulatory T donor cells in fetal mice after in utero allogeneic bone marrow transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2005 Bhattacharyya S, Cowan MJ -
Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression.
DNA repair 2005 Wang J, Pluth JM, Cooper PK, Cowan MJ, Chen DJ, Yannone SM -
Targeted disruption of the Artemis murine counterpart results in SCID and defective V(D)J recombination that is partially corrected with bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950) 2005 Li L, Salido E, Zhou Y, Bhattacharyya S, Yannone SM, Dunn E, Meneses J, Feeney AJ, Cowan MJ -
Simian immunodeficiency virus infection of hematopoietic stem cells and bone marrow stromal cells.
Journal of acquired immune deficiency syndromes (1999) 2004 Lee CI, Cowan MJ, Kohn DB, Tarantal AF -
Hepatic venoocclusive disease in blood and bone marrow transplantation in children and young adults: incidence, risk factors, and outcome in a cohort of 241 patients.
Journal of pediatric hematology/oncology 2002 Reiss U, Cowan M, McMillan A, Horn B -
Prenatal diagnosis and carrier detection for Athabascan severe combined immunodeficiency disease.
Prenatal diagnosis 2002 Li L, Zhou Y, Wang J, Hu D, Cowan MJ -
Non-invasive determination of the paternal HLA haplotype of a fetus using kinetic PCR to detect fetal microchimerism in maternal plasma.
Bone marrow transplantation 2002 Reed W, Kong DZ, Lee TH, Cowan MJ, Busch MP, Baxter-Lowe LA -
Veno-occlusive disease of the liver in children with solid tumors undergoing autologous hematopoietic progenitor cell transplantation: a high incidence in patients with neuroblastoma.
Bone marrow transplantation 2002 Horn B, Reiss U, Matthay K, McMillan A, Cowan M -
Increased engraftment and GVHD after in utero transplantation of MHC-mismatched bone marrow cells and CD80low, CD86(-) dendritic cells in a fetal mouse model.
Transplantation 2001 Chou SH, Chawla A, Lee TH, Zhou Y, Busch MP, Balassanian R, Ferrell L, Cowan MJ -
Target dose adjustment of busulfan in pediatric patients undergoing bone marrow transplantation.
Bone marrow transplantation 2001 Bolinger AM, Zangwill AB, Slattery JT, Risler LJ, Sultan DH, Glidden DV, Norstad D, Cowan MJ -
Bone marrow transplantation for T-B- severe combined immunodeficiency disease in Athabascan-speaking native Americans.
Bone marrow transplantation 2001 O'Marcaigh AS, DeSantes K, Hu D, Pabst H, Horn B, Li L, Cowan MJ -
Tolerance induction post in utero stem cell transplantation.
Ernst Schering Research Foundation workshop 2001 Cowan MJ, Chou SH, Tarantal AF -
Bone marrow transplantation for beta-thalassemia: the University of California San Francisco experience.
Journal of pediatric hematology/oncology 2000 Mentzer WC, Cowan MJ -
An evaluation of engraftment, toxicity and busulfan concentration in children receiving bone marrow transplantation for leukemia or genetic disease.
Bone marrow transplantation 2000 Bolinger AM, Zangwill AB, Slattery JT, Glidden D, DeSantes K, Heyn L, Risler LJ, Bostrom B, Cowan MJ -
Autoimmune hemolytic anemia in patients with SCID after T cell-depleted BM and PBSC transplantation.
Bone marrow transplantation 1999 Horn B, Viele M, Mentzer W, Mogck N, DeSantes K, Cowan M -
Oral and genital ulceration: a unique presentation of immunodeficiency in Athabascan-speaking American Indian children with severe combined immunodeficiency.
Archives of dermatology 1999 Kwong PC, O'Marcaigh AS, Howard R, Cowan MJ, Frieden IJ -
The gene for severe combined immunodeficiency disease in Athabascan-speaking Native Americans is located on chromosome 10p.
American journal of human genetics 1998 Li L, Drayna D, Hu D, Hayward A, Gahagan S, Pabst H, Cowan MJ -
Recruitment of engrafted donor cells postnatally into the blood with cytokines after in utero transplantation in mice.
Transplantation 1997 Carrier E, Lee TH, Busch MP, Cowan MJ -
Psychosocial consequences of bone marrow transplantation in donor and nondonor siblings.
Journal of developmental and behavioral pediatrics : JDBP 1997 Packman WL, Crittenden MR, Schaeffer E, Bongar B, Fischer JB, Cowan MJ -
In utero hematopoietic stem cell transplants prolong survival of postnatal kidney transplantation in monkeys.
Journal of pediatric surgery 1997 Mychaliska GB, Rice HE, Tarantal AF, Stock PG, Capper J, Garovoy MR, Olson JL, Cowan MJ, Harrison MR -
Bone marrow transplantation for inherited diseases.
Current opinion in oncology 1997 O'Marcaigh AS, Cowan MJ -
Cognitive and adaptive behavior 1 and 3 years following bone marrow transplantation.
Bone marrow transplantation 1997 Kramer JH, Crittenden MR, DeSantes K, Cowan MJ -
Maternal mosaicism for a novel interleukin-2 receptor gamma-chain mutation causing X-linked severe combined immunodeficiency in a Navajo kindred.
Journal of clinical immunology 1997 O'Marcaigh AS, Puck JM, Pepper AE, De Santes K, Cowan MJ -
In utero allogeneic hematopoietic stem cell transplantation to induce tolerance.
Fetal diagnosis and therapy 1996 Hajdu K, Tanigawara S, McLean LK, Cowan MJ, Golbus MS -
Haploidentical bone marrow transplants for two patients with reticular dysgenesis.
Bone marrow transplantation 1996 De Santes KB, Lai SS, Cowan MJ -
Long-term engraftment following in utero T cell-depleted parental marrow transplantation into fetal rhesus monkeys.
Bone marrow transplantation 1996 Cowan MJ, Tarantal AF, Capper J, Harrison M, Garovoy M -
Circulating red cells usually remain of host origin after bone marrow transplantation for severe combined immunodeficiency.
Transfusion 1996 Brady KA, Cowan MJ, Leavitt AD -
Induction of tolerance in nondefective mice after in utero transplantation of major histocompatibility complex-mismatched fetal hematopoietic stem cells.
Blood 1995 Carrier E, Lee TH, Busch MP, Cowan MJ -
Severe combined immunodeficiency with absence of peripheral blood CD8+ T cells due to ZAP-70 deficiency.
Cellular immunology 1995 Elder ME, Hope TJ, Parslow TG, Umetsu DT, Wara DW, Cowan MJ -
Renal transplantation without chronic immunosuppression after T cell-depleted, HLA-mismatched bone marrow transplantation.
Transplantation 1995 Sorof JM, Koerper MA, Portale AA, Potter D, DeSantes K, Cowan M -
Anti-tetanus toxoid antibody production after mismatched T cell-depleted bone marrow transplantation.
Journal of clinical immunology 1994 Benkerrou M, Wara DW, Elder M, Dror Y, Merino A, Colombe BW, Garovoy M, Cowan MJ -
In utero hematopoietic stem cell transplants for inherited diseases.
The American journal of pediatric hematology/oncology 1994 Cowan MJ, Golbus M -
Immune reconstitution in severe combined immunodeficiency disease after lectin-treated, T-cell-depleted haplocompatible bone marrow transplantation.
Blood 1993 Dror Y, Gallagher R, Wara DW, Colombe BW, Merino A, Benkerrou M, Cowan MJ -
Prenatal diagnosis of Chediak-Higashi syndrome.
Prenatal diagnosis 1992 Diukman R, Tanigawara S, Cowan MJ, Golbus MS -
A prospective study of cognitive functioning following low-dose cranial radiation for bone marrow transplantation.
Pediatrics 1992 Kramer JH, Crittenden MR, Halberg FE, Wara WM, Cowan MJ -
Characterization of three T-lymphoid cell lines with distinct sensitivities to deoxyadenosine plus deoxycoformycin.
Thymus 1992 Duan DS, Smith W, Sadée W, Cowan MJ -
Microgranulomatous aspergillosis after shoveling wood chips: report of a fatal outcome in a patient with chronic granulomatous disease.
American journal of industrial medicine 1992 Conrad DJ, Warnock M, Blanc P, Cowan M, Golden JA -
Hepatitis C virus infection in infants whose mothers took street drugs intravenously.
The Journal of pediatrics 1991 Weintrub PS, Veereman-Wauters G, Cowan MJ, Thaler MM -
Bone marrow transplantation for the treatment of genetic diseases.
Clinical biochemistry 1991 Cowan MJ -
Use of polymerase chain reaction for the early detection of HIV infection in the infants of HIV-seropositive women.
AIDS (London, England) 1991 Weintrub PS, Ulrich PP, Edwards JR, Boucher F, Levy JA, Cowan MJ, Vyas GN -
Detection of infection with human immunodeficiency virus (HIV) type 1 in infants by an anti-HIV immunoglobulin A assay using recombinant proteins.
The Journal of pediatrics 1991 Martin NL, Levy JA, Legg H, Weintrub PS, Cowan MJ, Wara DW -
Bone marrow transplantation for the treatment of genetic disease.
The Western journal of medicine 1990 Cowan MJ -
Total body irradiation and bone marrow transplantation for immunodeficiency disorders in young children.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 1990 Halberg FE, Wara WM, Weaver KE, Wara DW, Ablin AR, Matthay KK, Mentzer WC, O'Leary MC, Cowan MJ -
Interleukin 2 responsive lymphocytes in patients with adenosine deaminase deficiency.
Clinical immunology and immunopathology 1989 Cowan MJ, Smith W, Ammann AJ -
Familial bone marrow monosomy 7. Evidence that the predisposing locus is not on the long arm of chromosome 7.
The Journal of clinical investigation 1989 Shannon KM, Turhan AG, Chang SS, Bowcock AM, Rogers PC, Carroll WL, Cowan MJ, Glader BE, Eaves CJ, Eaves AC -
Polymerase chain reaction compared with concurrent viral cultures for rapid identification of human immunodeficiency virus infection among high-risk infants and children.
The Journal of pediatrics 1989 Edwards JR, Ulrich PP, Weintrub PS, Cowan MJ, Levy JA, Wara DW, Vyas GN -
Allogeneic bone marrow transplantation in newborn mice treated pre- and post-natally with anti-THY 1.2 monoclonal antibody.
Transplantation proceedings 1989 Culver KW, Smith WL, Cowan MJ -
Developmental decline in infants born to HIV-infected intravenous drug-using mothers.
NIDA research monograph 1989 Kletter R, Jeremy RJ, Rumsey C, Weintrub P, Cowan M -
Pediatric AIDS.
Immunology series 1989 Cowan MJ, Ammann AJ -
Maternally transmitted HIV infection in children.
AIDS (London, England) 1988 Cowan MJ, Walker C, Culver K, Weintrub PS, Wara DW, Levy JA -
Rejection of bone marrow transplant and resistance of alloantigen reactive cells to in vivo deoxyadenosine in adenosine deaminase deficiency.
Clinical immunology and immunopathology 1988 Cowan MJ, Shannon KM, Wara DW, Ammann AJ -
Human immuno-deficiency virus (HIV) infection in seronegative children of HIV infected mothers
AIDS 1988 Cowan, M.J., Walker, C., Culver, K., Wara, D., Weintrub, P.S., & Levy, J -
Risk of AIDS for recipients of blood components from donors who subsequently developed AIDS.
Blood 1987 Perkins HA, Samson S, Garner J, Echenberg D, Allen JR, Cowan M, Levy JA -
Lymphocyte abnormalities in infants born to drug-abusing mothers.
The Journal of pediatrics 1987 Culver KW, Ammann AJ, Partridge JC, Wong DF, Wara DW, Cowan MJ -
Haploidentical bone marrow transplantation using soybean agglutinin-processed, T-depleted marrow.
Transplantation proceedings 1987 Matthay K, Wara DW, Ablin AJ, Cowan MJ -
Lymphocyte reconstitution in children receiving soybean agglutinin T-depleted bone marrow transplants.
Transplantation proceedings 1987 Cowan MJ, McHugh T, Smith W, Wara D, Matthay K, Ablin A, Casavant C, Stites D -
Pediatric Bone Marrow Transplantation: Intensive Care Management
Journal of Intensive Care 1987 Shannon, K., Cowan, M.J., & Matthay, K. -
Probable autoimmune thyroid disease and combined immunodeficiency disease.
American journal of diseases of children (1960) 1986 Geffner ME, Stiehm ER, Stephure D, Cowan MJ -
Elevated erythrocyte adenosine deaminase activity in patients with acquired immunodeficiency syndrome.
Proceedings of the National Academy of Sciences of the United States of America 1986 Cowan MJ, Brady RO, Widder KJ -
Deoxycytidine therapy in two patients with adenosine deaminase deficiency and severe immunodeficiency disease.
Clinical immunology and immunopathology 1985 Cowan MJ, Wara DW, Ammann AJ -
A 90-day vapor inhalation toxicity study of decalin.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1985 Gaworski CL, Haun CC, MacEwen JD, Vernot EH, Bruner RH, Amster RL, Cowan MJ -
Behçet syndrome.
The Journal of pediatrics 1985 Ammann AJ, Johnson A, Fyfe GA, Leonards R, Wara DW, Cowan MJ -
Impaired mononuclear-cell proliferation in patients with the acquired immune deficiency syndrome results from abnormalities of both T lymphocytes and adherent mononuclear cells.
Journal of clinical immunology 1985 Shannon K, Cowan MJ, Ball E, Abrams D, Volberding P, Ammann AJ -
Antibodies to AIDS associated retrovirus distinguishes between primary and acquired immunodeficiency diseases
JAMA 1985 Ammann, A.J., Lawrence, K., & Cowan, M.J. -
Comparison of high-dose and low-dose intravenous immunoglobulin therapy in patients with primary immunodeficiency diseases.
The American journal of medicine 1984 Ochs HD, Fischer SH, Wedgwood RJ, Wara DW, Cowan MJ, Ammann AJ, Saxon A, Budinger MD, Allred RU, Rousell RH -
Maternal transmission of acquired immune deficiency syndrome.
Pediatrics 1984 Cowan MJ, Hellmann D, Chudwin D, Wara DW, Chang RS, Ammann AJ -
Susceptibility to infections in patients lacking a T lymphocyte surface glycoprotein
Clin Immunol Immunopathology 1984 Parkman, R., O'Donnell, R.E., Cairns, L., Rappeport, J.M., Cowan, M.J., Ammann, A.J., Kenney, D., Potter, N., & Rosen, F.S. -
Thymosin Fraction 5 treatment of patients with cellular immunodeficiency disorders
Thymic Hormones and Lymphokines 1984 Wara, D.W., Cowan, M.J., & Ammann, A.J. -
Immunologic abnormalities in patients with hemophilia A.
The Journal of pediatrics 1983 Weintrub PS, Koerper MA, Addiego JE, Drew WL, Lennette ET, Miner R, Cowan MJ, Ammann AJ -
Significance of a positive antinuclear antibody test in a pediatric population.
American journal of diseases of children (1960) 1983 Chudwin DS, Ammann AJ, Cowan MJ, Wara DW -
Chronic active Epstein-Barr virus infections in two immunodeficient patients.
The Journal of pediatrics 1983 Hellmann D, Cowan MJ, Ammann AJ, Wara DW, Chudwin D, Chang RS -
Response of agranulocytosis to prolonged antithymocyte globulin therapy.
The Journal of pediatrics 1983 Chudwin DS, Cowan MJ, Greenberg PL, Wara DW, Ammann AJ -
Alopecia and periorificial dermatitis in biotin-responsive multiple carboxylase deficiency.
Journal of the American Academy of Dermatology 1983 Williams ML, Packman S, Cowan MJ -
Acquired immune dysfunction in homosexual men: immunologic profiles.
Clinical immunology and immunopathology 1983 Ammann AJ, Abrams D, Conant M, Chudwin D, Cowan M, Volberding P, Lewis B, Casavant C -
Changes in purine nucleoside phosphorylase activity during thymosin-induced human null cell differentiation.
Cellular immunology 1983 Cowan MJ, Fraga M, Ammann AJ -
Clinical and laboratory findings in childhood mixed connective tissue disease: presence of antibody to ribonucleoprotein containing the small nuclear ribonucleic acid U1.
The Journal of pediatrics 1983 Savouret JF, Chudwin DS, Wara DW, Ammann AJ, Cowan MJ, Miller WL -
Acquired immunodeficiency in an infant: possible transmission by means of blood products.
Lancet (London, England) 1983 Ammann AJ, Cowan MJ, Wara DW, Weintrub P, Dritz S, Goldman H, Perkins HA -
Dipyridamole and intravenous deoxycytidine therapy in a patient with adenosine deaminase deficiency.
Birth defects original article series 1983 Ammann AJ, Cowan MJ, Martin DW, Wara DW -
Patients with abnormal proportions of T-lymphocyte subsets have reduced in vitro cellular immunity.
Clinical immunology and immunopathology 1983 Chudwin DS, Cowan MJ, Wara DW, Ammann AJ -
Unexplained immunodeficiency and opportunistic infections in infants--New York, New Jersey, California.
MMWR. Morbidity and mortality weekly report 1982 Centers for Disease Control (CDC) -
Possible transfusion-associated acquired immune deficiency syndrome (AIDS) - California.
MMWR. Morbidity and mortality weekly report 1982 Centers for Disease Control (CDC) -
Aspergillus pneumonia in chronic granulomatous disease: recurrence and long-term outcome.
Acta paediatrica Scandinavica 1982 Chudwin DS, Wara DW, Cowan MJ, Ammann AJ -
The DiGeorge syndrome and the fetal alcohol syndrome.
American journal of diseases of children (1960) 1982 Ammann AJ, Wara DW, Cowan MJ, Barrett DJ, Stiehm ER -
Posttransfusion syndrome. Rash, eosinophilia, and thrombocytopenia following intrauterine and exchange transfusions.
American journal of diseases of children (1960) 1982 Chudwin DS, Ammann AJ, Wara DW, Cowan MJ, Phibbs RH -
Prenatal treatment of biotin responsive multiple carboxylase deficiency.
Lancet (London, England) 1982 Packman S, Cowan MJ, Golbus MS, Caswell NM, Sweetman L, Burri BJ, Nyhan WL, Baker H -
Purine salvage pathway enzyme activities in human T-, B-, and null lymphocyte populations.
Cellular immunology 1982 Cowan MJ, Fraga M, Andrew J, Laméris-Martin N, Ammann AJ -
Effects of formycin B on human lymphocyte Deoxyribonucleic acid synthesis. Optimization of cell culture conditions.
Biochemical pharmacology 1981 Cowan MJ, Cashman D, Ammann AJ -
Biotin-responsive multiple carboxylase deficiency of infantile onset.
The Journal of pediatrics 1981 Packman S, Sweetman L, Yoshino M, Baker H, Cowan M -
Clinical and immunologic spectrum of the DiGeorge syndrome.
Journal of clinical & laboratory immunology 1981 Barrett DJ, Ammann AJ, Wara DW, Cowan MJ, Fisher TJ, Stiehm ER -
Lung involvement in progressive vaccinia.
The Western journal of medicine 1981 Chudwin DS, Cowan MJ, Wara DW, Johnson AC -
Immunodeficiency syndromes associated with inherited metabolic disorders.
Clinics in haematology 1981 Cowan MJ, Ammann AJ -
Aging and immunologic function: In vitro effects of thymosin on cellular immunity
Mech Aqinq and Development 1981 Cowan, M.J., Fujiwara, P., & Ammann, A.J. -
Immunology
AAP 1981 Ammann, A.J., Cowan, M.J., & Wara, D.W. -
Sjogren's syndrome in the pediatric age group
J Pediat. 1981 Chudwin, D.S., Daniels, T.E., Wara, D.W., Ammann, A.J., Barrett, D.J., Witcher, J.P., & Cowan, M.J. -
Cellular immune defect in selective IgA deficiency using a microculture method for PHA stimulation and limiting dilution.
Clinical immunology and immunopathology 1980 Cowan MJ, Fujiwara P, Ammann AJ -
Intermittent ataxia and immunodeficiency with multiple carboxylase deficiencies: a biotin-responsive disorder.
Annals of neurology 1980 Sander JE, Malamud N, Cowan MJ, Packman S, Amman AJ, Wara DW -
Collagen concentration and rates of synthesis in idiopathic pulmonary fibrosis.
The American review of respiratory disease 1980 Fulmer JD, Bienkowski RS, Cowan MJ, Breul SD, Bradley KM, Ferrans VJ, Roberts WC, Crystal RG -
Thymosin therapy in the DiGeorge syndrome.
The Journal of pediatrics 1980 Barrett DJ, Wara DW, Ammann AJ, Cowan MJ -
Multiple biotin-dependent carboxylase deficiencies associated with defects in T-cell and B-cell immunity.
Lancet (London, England) 1979 Cowan MJ, Wara DW, Packman S, Ammann AJ, Yoshino M, Sweetman L, Nyhan W -
In vitro and in vivo enhancement of mixed lymphocyte culture reactivity by thymosin in patients with primary immunodeficiency disease.
Annals of the New York Academy of Sciences 1979 Wara DW, Barrett DJ, Ammann AJ, Cowan MJ -
Pneumococcal polysaccharide immunization in infants and children.
Pediatrics 1978 Cowan MJ, Ammann AJ, Wara DW, Howie VM, Schultz L, Doyle N, Kaplan M -
Degradation of newly synthesized collagen.
The Journal of biological chemistry 1978 Bienkowski RS, Cowan MJ, McDonald JA, Crystal RG -
Alveolar multiplication in the contralateral lung after unilateral pneumonectomy in the rabbit.
The American review of respiratory disease 1977 Langston C, Sachdeva P, Cowan MJ, Haines J, Crystal RG, Thurlbeck WM -
Biochemical approaches to the investigation of fibrotic lung disease.
Chest 1976 Hance AJ, Horwitz AL, Cowan MJ, Elson NA, Collins JF, Bienkowski RS, Bradley KH, McConnell-Breul S, Wagner WM, Crystal RG -
Lung growth after unilateral pneumonectomy: quantitation of collagen synthesis and content.
The American review of respiratory disease 1975 Cowan MJ, Crystal RG -
Collagen in the lung: development of a technology applicable to human lung disease.
Chest 1975 Crystal RG, Bradley KH, McConnell-Breu SD, Collins JF, Hanca AJ, Cowan MJ -
Workshop on possible pharmacologic mechanisms for enhancement of lung maturation.
The American review of respiratory disease 1974 Cowan MJ