Morna Dorsey, MD, MS
Professor
Pediatrics
School of Medicine

My research interests lie in three main focus areas: 1. Optimizing diagnosis and care of patients with primary immunodeficiency 2. Investigating the psychosocial impact of primary immunodeficiency on patients and families 3. Establishing treatment for patients with food allergy and eosinophilic disorders

Grants and Projects

Show all (2) Hide

• Collaborative multi-site project to speed the identification and management of rare genetic immune diseases, NIH, 2021-2026
• California Severe Combined Immunodeficiency Consortium Long-term Follow-up Program (CalSCID), HRSA, 2021-2023

Publications (47)

Top publication keywords:
NF-KappaB Inhibitor alphaGranulomatous Disease, ChronicPatientsAgammaglobulinemiaMycobacterium avium ComplexImmunologic Deficiency SyndromesHematopoietic Stem Cell TransplantationPeanut HypersensitivityGraft vs Host DiseaseSevere Combined ImmunodeficiencyLymphopeniaInfection ControlMycobacterium avium-intracellulare InfectionAdenosine DeaminaseNeonatal Screening

• Genotype, oxidase status, and preceding infection or autoinflammation do not affect allogeneic HCT outcomes for CGD.
  Blood 2023 Leiding JW, Arnold DE, Parikh S, Logan B, Marsh RA, Griffith LM, Wu R, Kidd S, Mallhi K, Chellapandian D, Si Lim SJ, Grunebaum E, Falcone EL, Murguia-Favela L, Grossman D, Prasad VK, Heimall JR, …
• Correction to: PEGylated Recombinant Adenosine Deaminase Maintains Detoxification and Lymphocyte Counts in Patients with ADA-SCID.
  Journal of clinical immunology 2023 Dorsey MJ, Rubinstein A, Lehman H, Fausnight T, Wiley JM, Haddad E
• Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy.
  The New England journal of medicine 2023 Greenhawt M, Sindher SB, Wang J, O'Sullivan M, du Toit G, Kim EH, Albright D, Anvari S, Arends N, Arkwright PD, Bégin P, Blumchen K, Bourrier T, Brown-Whitehorn T, Cassell H, Chan ES, Ciaccio CE, …
• Improving Access to Therapy for Patients With Inborn Errors of Immunity: A Call to Action.
  The journal of allergy and clinical immunology. In practice 2023 Dorsey MJ, Condino-Neto A
• PEGylated Recombinant Adenosine Deaminase Maintains Detoxification and Lymphocyte Counts in Patients with ADA-SCID.
  Journal of clinical immunology 2023 Dorsey MJ, Rubinstein A, Lehman H, Fausnight T, Wiley JM, Haddad E

Show all (42 more) Hide

• Impact of Genetic Diagnosis on the Outcome of Hematopoietic Stem Cell Transplant in Primary Immunodeficiency Disorders.
  Journal of clinical immunology 2022 Forlanini F, Chan A, Dara J, Dvorak CC, Cowan MJ, Puck JM, Dorsey MJ
• Outcomes following treatment for ADA-deficient severe combined immunodeficiency: a report from the PIDTC.
  Blood 2022 Cuvelier GDE, Logan BR, Prockop SE, Buckley RH, Kuo CY, Griffith LM, Liu X, Yip A, Hershfield MS, Ayoub PG, Moore TB, Dorsey MJ, O'Reilly RJ, Kapoor N, Pai SY, Kapadia M, Ebens CL, Forbes Satter LR, …
• Disease Progression of WHIM Syndrome in an International Cohort of 66 Pediatric and Adult Patients.
  Journal of clinical immunology 2022 Geier CB, Ellison M, Cruz R, Pawar S, Leiss-Piller A, Zmajkovicova K, McNulty SM, Yilmaz M, Evans MO, Gordon S, Ujhazi B, Wiest I, Abolhassani H, Aghamohammadi A, Barmettler S, Bhar S, Bondarenko A, …
• Eczema and Petechiae in an Infant.
  Pediatrics in review 2022 Lloyd-McLennan AM, Shimano KA, Dorsey M, Cordoro KM
• Correction to: Infections in Infants with SCID: Isolation, Infection Screening and Prophylaxis in PIDTC Centers.
  Journal of clinical immunology 2021 Dorsey M, Wright NAM, Chaimowitz NS, Dávila Saldaña BJ, Miller H, Keller MD, Thakar MS, Shah AJ, Abu-Arja R, Andolina J, Aquino V, Barnum JL, Bednarski JJ, Bhatia M, Bonilla FA, Butte MJ, Bunin NJ, …
• When Screening for Severe Combined Immunodeficiency (SCID) with T Cell Receptor Excision Circles Is Not SCID: a Case-Based Review.
  Journal of clinical immunology 2021 Buchbinder D, Walter JE, Butte MJ, Chan WY, Chitty Lopez M, Dimitriades VR, Dorsey MJ, Nugent DJ, Puck JM, Singh J, Collins CA
• Continuous and Daily Oral Immunotherapy for Peanut Allergy: Results from a 2-Year Open-Label Follow-On Study.
  The journal of allergy and clinical immunology. In practice 2020 Vickery BP, Vereda A, Nilsson C, du Toit G, Shreffler WG, Burks AW, Jones SM, Fernández-Rivas M, Blümchen K, O'B Hourihane J, Beyer K, Anagnostou A, Assa'ad AH, Ben-Shoshan M, Bird JA, Carr TF, Carr …
• Unknown cytomegalovirus serostatus in primary immunodeficiency disorders: A new category of transplant recipients.
  Transplant infectious disease : an official journal of the Transplantation Society 2020 Forlanini F, Dara J, Dvorak CC, Cowan MJ, Puck JM, Dorsey MJ
• Folliculotropic mycosis fungoides driven by DOCK8 immunodeficiency syndrome.
  Pediatric dermatology 2020 Rubio-Gonzalez B, Frieden IJ, McCalmont TH, Dorsey M, Funk T, Pincus LB
• Infections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers.
  Journal of clinical immunology 2020 Dorsey MJ, Wright NAM, Chaimowitz NS, Dávila Saldaña BJ, Miller H, Keller MD, Thakar MS, Shah AJ, Abu-Arja R, Andolina J, Aquino V, Barnum JL, Bednarski JJ, Bhatia M, Bonilla FA, Butte MJ, Bunin NJ, …
• Transfer of monoclonal antibodies into breastmilk in neurologic and non-neurologic diseases.
  Neurology(R) neuroimmunology & neuroinflammation 2020 LaHue SC, Anderson A, Krysko KM, Rutatangwa A, Dorsey MJ, Hale T, Mahadevan U, Rogers EE, Rosenstein MG, Bove R
• Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey.
  Frontiers in immunology 2020 Chan AY, Leiding JW, Liu X, Logan BR, Burroughs LM, Allenspach EJ, Skoda-Smith S, Uzel G, Notarangelo LD, Slatter M, Gennery AR, Smith AR, Pai SY, Jordan MB, Marsh RA, Cowan MJ, Dvorak CC, Craddock JA…
• Lentiviral gene therapy for X-linked chronic granulomatous disease.
  Nature medicine 2020 Kohn DB, Booth C, Kang EM, Pai SY, Shaw KL, Santilli G, Armant M, Buckland KF, Choi U, De Ravin SS, Dorsey MJ, Kuo CY, Leon-Rico D, Rivat C, Izotova N, Gilmour K, Snell K, Dip JX, Darwish J, Morris EC…
• Extended Follow-up After Hematopoietic Cell Transplantation for IκBα Deficiency with Disseminated Mycobacterium avium Infection.
  Journal of clinical immunology 2019 Seghezzo SP, Dvorak CC, Cowan MJ, Puck JM, Dorsey MJ
• Diagnostic interpretation of genetic studies in patients with primary immunodeficiency diseases: A working group report of the Primary Immunodeficiency Diseases Committee of the American Academy of Allergy, Asthma & Immunology.
  The Journal of allergy and clinical immunology 2019 Chinn IK, Chan AY, Chen K, Chou J, Dorsey MJ, Hajjar J, Jongco AM, Keller MD, Kobrynski LJ, Kumanovics A, Lawrence MG, Leiding JW, Lugar PL, Orange JS, Patel K, Platt CD, Puck JM, Raje N, Romberg N, …
• TASP1 mutation in a female with craniofacial anomalies, anterior segment dysgenesis, congenital immunodeficiency and macrocytic anemia.
  Molecular genetics & genomic medicine 2019 Balkin DM, Poranki M, Forester CM, Dorsey MJ, Slavotinek A, Pomerantz JH
• Low Exposure Busulfan Conditioning to Achieve Sufficient Multilineage Chimerism in Patients with Severe Combined Immunodeficiency.
  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2019 Dvorak CC, Long-Boyle J, Dara J, Melton A, Shimano KA, Huang JN, Puck JM, Dorsey MJ, Facchino J, Chang CK, Cowan MJ
• Newborn Screening for Severe Combined Immunodeficiency and T-cell Lymphopenia in California, 2010-2017.
  Pediatrics 2019 Amatuni GS, Currier RJ, Church JA, Bishop T, Grimbacher E, Nguyen AA, Agarwal-Hashmi R, Aznar CP, Butte MJ, Cowan MJ, Dorsey MJ, Dvorak CC, Kapoor N, Kohn DB, Markert ML, Moore TB, Naides SJ, …
• Outcomes for Nitazoxanide Treatment in a Case Series of Patients with Primary Immunodeficiencies and Rubella Virus-Associated Granuloma.
  Journal of clinical immunology 2019 Perelygina L, Buchbinder D, Dorsey MJ, Eloit M, Hauck F, Hautala T, Moshous D, Uriarte I, Deripapa E, Icenogle J, Sullivan KE
• AR101 Oral Immunotherapy for Peanut Allergy.
  The New England journal of medicine 2018 PALISADE Group of Clinical Investigators, Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G, Hourihane JO, Jones SM, Shreffler WG, Marcantonio A, Zawadzki R, Sher L, Carr WW, Fineman S, Greos L, …
• Newborn Screening for Severe Combined Immunodeficiency in the United States: Lessons Learned.
  Immunology and allergy clinics of North America 2018 Dorsey MJ, Puck JM
• Supporting caregivers during hematopoietic cell transplantation for children with primary immunodeficiency disorders.
  The Journal of allergy and clinical immunology 2018 Yoo J, Halley MC, Lown EA, Yank V, Ort K, Cowan MJ, Dorsey MJ, Smith H, Iyengar S, Scalchunes C, Mangurian C
• Neurologic event-free survival demonstrates a benefit for SCID patients diagnosed by newborn screening.
  Blood advances 2017 Dvorak CC, Puck JM, Wahlstrom JT, Dorsey M, Melton A, Cowan MJ
• Newborn Screening for Severe Combined Immunodeficiency in the US: Current Status and Approach to Management.
  International journal of neonatal screening 2017 Dorsey M, Puck J
• Treatment of infants identified as having severe combined immunodeficiency by means of newborn screening.
  The Journal of allergy and clinical immunology 2017 Dorsey MJ, Dvorak CC, Cowan MJ, Puck JM
• Gastrointestinal Manifestations in X-linked Agammaglobulinemia.
  Journal of clinical immunology 2017 Barmettler S, Otani IM, Minhas J, Abraham RS, Chang Y, Dorsey MJ, Ballas ZK, Bonilla FA, Ochs HD, Walter JE
• Update on the use of immunoglobulin in human disease: A review of evidence.
  The Journal of allergy and clinical immunology 2016 Perez EE, Orange JS, Bonilla F, Chinen J, Chinn IK, Dorsey M, El-Gamal Y, Harville TO, Hossny E, Mazer B, Nelson R, Secord E, Jordan SC, Stiehm ER, Vo AA, Ballow M
• Longstanding Eosinophilia in a Case of Late Diagnosis Chronic Granulomatous Disease.
  Journal of clinical immunology 2016 Nguyen A, Patel K, Puck J, Dorsey M
• Long-term outcomes of 176 patients with X-linked hyper-IgM syndrome treated with or without hematopoietic cell transplantation.
  The Journal of allergy and clinical immunology 2016 de la Morena MT, Leonard D, Torgerson TR, Cabral-Marques O, Slatter M, Aghamohammadi A, Chandra S, Murguia-Favela L, Bonilla FA, Kanariou M, Damrongwatanasuk R, Kuo CY, Dvorak CC, Meyts I, Chen K, …
• Efficacy and tolerability of 16% subcutaneous immunoglobulin compared with 20% subcutaneous immunoglobulin in primary antibody deficiency.
  Clinical and experimental immunology 2015 Niebur HB, Duff CM, Shear GF, Nguyen D, Alberdi TK, Dorsey MJ, Sleasman JW
• Fiscal implications of newborn screening in the diagnosis of severe combined immunodeficiency.
  The journal of allergy and clinical immunology. In practice 2014 Kubiak C, Jyonouchi S, Kuo C, Garcia-Lloret M, Dorsey MJ, Sleasman J, Zbrozek AS, Perez EE
• Clinical experience with an L-proline–stabilized 10 %intravenous immunoglobulin (Privigen®): real-life effectiveness and tolerability.
  Journal of clinical immunology 2014 Dorsey MJ, Ho V, Mabudian M, Soler-Palacín P, Domínguez-Pinilla N, Rishi R, Rishi R, Wong D, Rojavin M, Hubsch A, Berger M
• Alterations in regulatory T cell subpopulations seen in preterm infants.
  PloS one 2014 Luciano AA, Arbona-Ramirez IM, Ruiz R, Llorens-Bonilla BJ, Martinez-Lopez DG, Funderburg N, Dorsey MJ
• Chronic granulomatous disease associated colitis leading to profound zinc deficiency.
  The journal of allergy and clinical immunology. In practice 2013 Ladinsky HT, Perez EE, Dorsey MJ
• Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome.
  The Journal of allergy and clinical immunology 2013 Uzel G, Sampaio EP, Lawrence MG, Hsu AP, Hackett M, Dorsey MJ, Noel RJ, Verbsky JW, Freeman AF, Janssen E, Bonilla FA, Pechacek J, Chandrasekaran P, Browne SK, Agharahimi A, Gharib AM, Mannurita SC, …
• Intensive educational course in allergy and immunology.
  Allergy 2012 Elizalde A, Perez EE, Sriaroon P, Nguyen D, Lockey RF, Dorsey MJ
• FOXP3 expression following bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning.
  Immunologic research 2009 Dorsey MJ, Petrovic A, Morrow MR, Dishaw LJ, Sleasman JW
• Complete DiGeorge syndrome associated with CHD7 mutation.
  The Journal of allergy and clinical immunology 2007 Sanka M, Tangsinmankong N, Loscalzo M, Sleasman JW, Dorsey MJ
• Impaired specific antibody response and increased B-cell population in transient hypogammaglobulinemia of infancy.
  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2006 Dorsey MJ, Orange JS
• Assessment of adrenal suppression in children with asthma treated with inhaled corticosteroids: use of dehydroepiandrosterone sulfate as a screening test.
  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2006 Dorsey MJ, Cohen LE, Phipatanakul W, Denufrio D, Schneider LC
• Use of a fish oil-based lipid emulsion to treat essential fatty acid deficiency in a soy allergic patient receiving parenteral nutrition.
  Clinical nutrition (Edinburgh, Scotland) 2005 Gura KM, Parsons SK, Bechard LJ, Henderson T, Dorsey M, Phipatanakul W, Duggan C, Puder M, Lenders C
• Mutations in the iron-sulfur cluster ligands of the human ferrochelatase lead to erythropoietic protoporphyria.
  Blood 2000 Schneider-Yin X, Gouya L, Dorsey M, Rüfenacht U, Deybach JC, Ferreira GC