Monita Muralidharan, PhD
Assistant Researcher
Quantitative_Bioscience_Ins
School of Pharmacy

Publications (21)

Top publication keywords:
ProteomeCysteineMass SpectrometrySpectrometry, Mass, Electrospray IonizationProteomicsGlutathioneHemoglobinsInterferonsDeuterium Exchange MeasurementProtein ConformationDinitrobenzenesGlycemic IndexHemoglobins, AbnormalErythrocytesIon Mobility Spectrometry

• Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response.
  eLife 2025 San Felipe CJ, Batra J, Muralidharan M, Malpotra S, Anand D, Bauer R, Verba KA, Swaney DL, Krogan NJ, Grabe M, Fraser JS
• Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response.
  bioRxiv : the preprint server for biology 2025 Felipe CS, Batra J, Muralidharaan M, Malpotra S, Anand D, Bauer R, Verba KA, Swaney DL, Krogan NJ, Grabe M, Fraser JS
• Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication.
  bioRxiv : the preprint server for biology 2025 Batra J, Rutkowska M, Zhou Y, Ye C, Adavikolanu R, Young JM, Anand D, Verma S, Gordon M, Malpotra S, Cupic A, Kehrer T, Moen JM, Winters DM, Rojc A, Mena I, Aslam S, Martinez-Romero C, Conde Viñas I, …
• A PERTURBATION CELL ATLAS OF HUMAN INDUCED PLURIPOTENT STEM CELLS.
  bioRxiv : the preprint server for biology 2024 Nourreddine S, Doctor Y, Dailamy A, Forget A, Lee YH, Chinn B, Khaliq H, Polacco B, Muralidharan M, Pan E, Zhang Y, Sigaeva A, Hansen JN, Gao J, Parker JA, Obernier K, Clark T, Chen JY, Metallo C, …
• Current proteomics methods applicable to dissecting the DNA damage response.
  NAR cancer 2023 Muralidharan M, Krogan NJ, Bouhaddou M, Kim M

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• Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
• Proteomic Approaches to Study SARS-CoV-2 Biology and COVID-19 Pathology.
  Journal of proteome research 2021 Haas P, Muralidharan M, Krogan NJ, Kaake RM, Hüttenhain R
• The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
  Cell 2020 Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, Richards AL, Stevenson E, Gordon DE, Rojc A, Obernier K, Fabius JM, Soucheray…
• Structural analysis of glycated human hemoglobin using native mass spectrometry.
  The FEBS journal 2019 Muralidharan M, Bhat V, Mandal AK
• Structural analysis of glutathionyl hemoglobin using native mass spectrometry.
  Journal of structural biology 2019 Muralidharan M, Mitra A, Maity D, Pal D, Mandal AK
• Glycation profile of minor abundant erythrocyte proteome across varying glycemic index in diabetes mellitus.
  Analytical biochemistry 2019 Muralidharan M, Bhat V, Bindu YS, Mandal AK
• Characterization of residue-specific glutathionylation of CSF proteins in multiple sclerosis - A MS-based approach.
  Analytical biochemistry 2018 Srivastava D, Kukkuta Sarma GR, Dsouza DS, Muralidharan M, Srinivasan K, Mandal AK
• Conformational heterogeneity of tau: Implication on intrinsic disorder, acid stability and fibrillation in Alzheimer's disease.
  Biophysical chemistry 2018 Jebarupa B, Muralidharan M, Arun A, Mandal AK, Mitra G
• Effect of altered solution conditions on tau conformational dynamics: Plausible implication on order propensity and aggregation.
  Biochimica et biophysica acta. Proteins and proteomics 2018 Jebarupa B, Muralidharan M, Srinivasu BY, Mandal AK, Mitra G
• Analysis of the Quaternary Structure of Hemoglobin Beckman Variant and Molecular Interpretation of Its Functional Abnormality: A Mass-Spectrometry-Based Approach.
  Chembiochem : a European journal of chemical biology 2018 Muralidharan M, Das R, Bhat V, Mandal AK
• Assessment of Cysteine Reactivity of Human Hemoglobin at Its Residue Level: A Mass Spectrometry-Based Approach.
  Hemoglobin 2017 Mitra A, Muralidharan M, Srivastava D, Das R, Bhat V, Mandal AK
• Interaction of p-benzoquinone with hemoglobin in smoker's blood causes alteration of structure and loss of oxygen binding capacity.
  Toxicology reports 2016 Ghosh A, Banerjee S, Mitra A, Muralidharan M, Roy B, Banerjee R, Mandal AK, Chatterjee IB
• Protein Structure-Function Correlation in Living Human Red Blood Cells Probed by Isotope Exchange-based Mass Spectrometry.
  Analytical chemistry 2015 Narayanan S, Mitra G, Muralidharan M, Mathew B, Mandal AK
• Mass spectrometry based characterization of Hb Beckman variant in a falsely elevated HbA(1c) sample.
  Analytical biochemistry 2015 Das R, Muralidharan M, Mitra G, Bhat V, Mathew B, Pal D, Ross C, Mandal AK
• Glutathionylation induced structural changes in oxy human hemoglobin analyzed by backbone amide hydrogen/deuterium exchange and MALDI-mass spectrometry.
  Bioconjugate chemistry 2012 Mitra G, Muralidharan M, Narayanan S, Pinto J, Srinivasan K, Mandal AK
• Structural perturbation of human hemoglobin on glutathionylation probed by hydrogen-deuterium exchange and MALDI mass spectrometry.
  Bioconjugate chemistry 2011 Mitra G, Muralidharan M, Pinto J, Srinivasan K, Mandal AK