Mingliang Jin, PhD
Postdoctoral Scholar
Biochemistry and Biophysics
School of Medicine

Education & Training

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• PhD SIBCB 05/2019

Publications (13)

Top publication keywords:
Group II ChaperoninsCryoelectron MicroscopyProtein FoldingSaccharomyces cerevisiaeChaperonin Containing TCP-1Receptors, NeurotensinAdenosine TriphosphateProtein Subunitsbeta-Arrestin 2Immediate-Early ProteinsMonomeric GTP-Binding ProteinsRapamycin-Insensitive Companion of mTOR ProteinSingle-Domain AntibodiesChaperoninsATP-Dependent Proteases

• Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
  The Journal of biological chemistry 2022 Yu Z, Chen J, Takagi E, Wang F, Saha B, Liu X, Joubert LM, Gleason CE, Jin M, Li C, Nowotny C, Agard D, Cheng Y, Pearce D
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  Research square 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  bioRxiv : the preprint server for biology 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
  Science (New York, N.Y.) 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…
• An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation.
  bioRxiv : the preprint server for biology 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…

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• A complex structure of arrestin-2 bound to a G protein-coupled receptor.
  Cell research 2019 Yin W, Li Z, Jin M, Yin YL, de Waal PW, Pal K, Yin Y, Gao X, He Y, Gao J, Wang X, Zhang Y, Zhou H, Melcher K, Jiang Y, Cong Y, Edward Zhou X, Yu X, Eric Xu H
• An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Jin M, Han W, Liu C, Zang Y, Li J, Wang F, Wang Y, Cong Y
• TRiC/CCT Chaperonin: Structure and Function.
  Sub-cellular biochemistry 2019 Jin M, Liu C, Han W, Cong Y
• Development of a yeast internal-subunit eGFP labeling strategy and its application in subunit identification in eukaryotic group II chaperonin TRiC/CCT.
  Scientific reports 2018 Zang Y, Wang H, Cui Z, Jin M, Liu C, Han W, Wang Y, Cong Y
• Structural insights into the oligomerization of FtsH periplasmic domain from Thermotoga maritima.
  Biochemical and biophysical research communications 2017 An JY, Sharif H, Kang GB, Park KJ, Lee JG, Lee S, Jin MS, Song JJ, Wang J, Eom SH
• Identification of an allosteric network that influences assembly and function of group II chaperonins.
  Nature structural & molecular biology 2017 Jin M, Cong Y
• Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5.
  Genes & development 2016 Jin W, Wang Y, Liu CP, Yang N, Jin M, Cong Y, Wang M, Xu RM
• Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM.
  Nature structural & molecular biology 2016 Zang Y, Jin M, Wang H, Cui Z, Kong L, Liu C, Cong Y