Joseph "Mike" McCune, MD, PhD
Professor
Medicine
School of Medicine
Joseph ("Mike") McCune is a professor of medicine at the University of California, San Francisco (UCSF). He received his AB degree from Harvard College in 1975, his PhD degree from Rockefeller University in 1981, and his MD degree from Cornell University Medical College in 1982. He completed his residency in internal medicine in 1984 and did fellowship training in infectious diseases at UCSF.
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He is board certified in internal medicine.
The McCune lab has been involved for many years in the analysis of HIV pathogenesis, prevention, treatment, and cure. Dr. McCune started to treat patients with HIV disease as a resident in internal medicine at UCSF in 1982 and has been involved in the HIV/AIDS research field ever since. This work included postdoctoral studies at Stanford, exploring the fusogenic properties of the HIV envelope protein and developing the first humanized mouse model (the SCID-hu mouse) capable of multilineage human hematopoiesis and receptive to infection with primary isolates of HIV. He then co-founded the companies SyStemix (in 1988) and Progenesys (and 1991), serving as Scientific Director and leading research efforts to find better ways – including antiviral medications and hematopoietic stem cell-based gene therapy – to treat HIV disease. In 1995, Dr. McCune returned to academia, first as an investigator at the Gladstone Institute of Virology and Immunology and then (from 2006-2016) as the Chief of the Division of Experimental Medicine (which he founded) at UCSF. Concomitantly, he was the founding PI (and Senior Associate Dean) of the Clinical and Translational Sciences Institute at UCSF (from 2005-08). In recent years, he has helped to form multidisciplinary, collaborative research teams to find a cure for HIV disease. Throughout this time, he has actively mentored graduate students and postdoctoral fellows, many of whom have gone on to successful careers in academia or biotech/pharma.
Dr. McCune’s studies have led to the publication of over 200 peer-reviewed articles, and he is the holder of 20 patents and inventions. He is a member of many scientific and professional societies, including the American Society for Clinical Investigation, the American Association of Physicians, and the Henry Kunkel Society. He has served on the editorial boards of Virology and the Journal of the Acquired Immune Deficiency Syndrome. He was awarded the Elizabeth Glaser Pediatric AIDS Foundation Scientist Award in 1996, the Burroughs Wellcome Fund Clinical Scientist Award in Translational Research in 2000, a MERIT Award from the NIH in 2001, the NIH Director’s Pioneer Award in 2004, and the Holly Smith Award for Exceptional Service to the School of Medicine in 2016. He was also selected to give the UCSF Academic Senate Faculty Research Lecture (on Translational Science) in 2013.
Education & Training
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- Post-Doc Fellow/Scholar Pathology Stanford University Medical College 1988
- Clinical Fellowship Infectious Disease University of California, San Francisco 1986
- Residency Internal Medicine University of California, San Francisco 1984
- M.D. Medicine Cornell University Medical College 1982
- Ph.D. Cell Biology/Immunology The Rockefeller University 1981
- A.B. Biochemistry Harvard College 1975
Websites
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- Profile at UCSF Cancer Center (cancer.ucsf.edu)
- McCune Lab Website (experimental.medicine.ucsf.edu)
Grants and Projects
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- Timing of ART and homeostasis of the persistent HIV reservoir in the adult, NIH, 2015-2021
- The impact of TB co-infection on the reservoir of persistent HIV in vivo, NIH, 2015-2018
- Interferon-independent mechanisms of malaria restriction by helper T cells, NIH, 2015-2017
- Layering of the human immune system, viral infections, and childhood asthma, NIH, 2012-2017
- DARE: Delaney AIDS Research Enterprise to find a cure., NIH, 2011-2017
- Clinical and Translational Science Institute, NIH, 2006-2016
- Clinical and Transtional Science Institute, NIH, 2006-2016
- Clinical and Transtional Science Institute, NIH, 2006-2016
- Bay Area Hepatitis C Cooperative Research Center, NIH, 2010-2016
- Novel flow cytometry-based assay for HIV-infected cells, NIH, 2013-2015
- The Impact of Tolerance in the Newborn on Lentiviral Infection, NIH, 2010-2015
- California National Primate Research Center, NIH, 1975-2015
- Interruption of maternal-fetal transmission of HIV, NIH, 2009-2014
- Human immune system layering and the neonatal response to vaccines, NIH, 2011-2014
- HIV Proteomic Center for Host-Viral Response Characterization, NIH, 2008-2012
- Hiv Effects on the Central Hematolymphoid System, NIH, 1996-2012
- NIH Director's Pioneer Award (RMI), NIH, 2004-2010
- Thymic Function in Adults With HIV-1 Disease, NIH, 1999-2010
- Anti-Gag Antibodies and Enhancement of Lentiviral Disease Progression, NIH, 2006-2009
- Assessing Laboratory Correlates of Immune Protection, NIH, 2000-2008
- General Clinical Research Center, NIH, 1974-2007
- Human Immune Cell Maturation During Ontogeny and Infecti, NIH, 1999-2003
- Beckman Coulter BioMek 2000 Workstation and Accessories, NIH, 2002-2003
- Thymic Function in Adults with Hiv1 Disease, NIH, 1999-2003
- Moflo Tm High Performance Flow Cytometer, NIH, 2000-2002
- Scid-hu Animal Model for Evaluating Hiv Therapies, NIH, 1996-2000
- Hiv Effects on the Central Hematolymphoid System in Vivo, NIH, 1996-2000
- Hiv Infection in the Scid-hu Mouse, NIH, 1989-1995
- Discovery and Development of Therapeutic Compounds, NIH, 1993-1994
Publications (256)
Top publication keywords:
FetusCD8-Positive T-LymphocytesIndoleamine-Pyrrole 2,3,-DioxygenaseHIV InfectionsT-Lymphocyte SubsetsReceptors, CCR5HIV-1Hematopoietic Stem CellsHIVThymus GlandT-Lymphocytes, RegulatoryViral LoadCD4-Positive T-LymphocytesSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency Virus
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Erratum to: Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner?
Pathogens & immunity 2024 Harper J, Betts MR, Lichterfeld M, Müller-Trutwin M, Margolis D, Bar KJ, Li JZ, McCune JM, Lewin SR, Kulpa D, Ávila-Ríos S, Diallo DD, Lederman MM, Paiardini M -
Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner?
Pathogens & immunity 2024 Harper J, Betts MR, Lichterfeld M, Müller-Trutwin M, Margolis D, Bar KJ, Li JZ, McCune JM, Lewin SR, Kulpa D, Diallo DD, Lederman MM, Paiardini M -
The promise of a "cure" for HIV: implications for the future of PEPFAR-supported HIV programmes.
Journal of the International AIDS Society 2024 Raizes E, Blandford J, McCune JM, Dybul M -
Estimating the contribution of CD4 T cell subset proliferation and differentiation to HIV persistence.
Nature communications 2023 Reeves DB, Bacchus-Souffan C, Fitch M, Abdel-Mohsen M, Hoh R, Ahn H, Stone M, Hecht F, Martin J, Deeks SG, Hellerstein MK, McCune JM, Schiffer JT, Hunt PW -
Recent Advances Using Genetic Therapies Against Infectious Diseases and for Vaccination.
Human gene therapy 2023 Galy A, Berkhout B, Breckpot K, Pichon C, Bloom K, Kiem HP, Mühlebach MD, McCune JM
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Human fetal T cells: Insights into developmental specialization and mechanisms of lineage transition.
Immunological reviews 2023 Burt TD, McCune JM -
IFN-α blockade during ART-treated SIV infection lowers tissue vDNA, rescues immune function, and improves overall health.
JCI insight 2022 Swainson LA, Sharma AA, Ghneim K, Ribeiro SP, Wilkinson P, Dunham RM, Albright RG, Wong S, Estes JD, Piatak M, Deeks SG, Hunt PW, Sekaly RP, McCune JM -
HIV-1 Genomes Are Enriched in Memory CD4+ T-Cells with Short Half-Lives.
mBio 2021 Morcilla V, Bacchus-Souffan C, Fisher K, Horsburgh BA, Hiener B, Wang XQ, Schlub TE, Fitch M, Hoh R, Hecht FM, Martin JN, Deeks SG, Hellerstein MK, McCune JM, Hunt PW, Palmer S -
Collaborative science to advance gene therapies in resource-limited parts of the world.
Molecular therapy : the journal of the American Society of Gene Therapy 2021 McCune JM, Stevenson SC, Doehle BP, Trenor CC, Turner EH, Spector JM -
TCF-1 regulates HIV-specific CD8+ T cell expansion capacity.
JCI insight 2021 Rutishauser RL, Deguit CDT, Hiatt J, Blaeschke F, Roth TL, Wang L, Raymond KA, Starke CE, Mudd JC, Chen W, Smullin C, Matus-Nicodemos R, Hoh R, Krone M, Hecht FM, Pilcher CD, Martin JN, Koup RA, Douek… -
Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART.
PLoS pathogens 2021 Bacchus-Souffan C, Fitch M, Symons J, Abdel-Mohsen M, Reeves DB, Hoh R, Stone M, Hiatt J, Kim P, Chopra A, Ahn H, York VA, Cameron DL, Hecht FM, Martin JN, Yukl SA, Mallal S, Cameron PU, Deeks SG, … -
Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells.
Cell reports 2021 Bunis DG, Bronevetsky Y, Krow-Lucal E, Bhakta NR, Kim CC, Nerella S, Jones N, Mendoza VF, Bryson YJ, Gern JE, Rutishauser RL, Ye CJ, Sirota M, McCune JM, Burt TD -
CD57+ Memory T Cells Proliferate In Vivo.
Cell reports 2020 Ahmed R, Miners KL, Lahoz-Beneytez J, Jones RE, Roger L, Baboonian C, Zhang Y, Wang ECY, Hellerstein MK, McCune JM, Baird DM, Price DA, Macallan DC, Asquith B, Ladell K -
Multi-stakeholder consensus on a target product profile for an HIV cure.
The lancet. HIV 2020 Lewin SR, Attoye T, Bansbach C, Doehle B, Dubé K, Dybul M, SenGupta D, Jiang A, Johnston R, Lamplough R, McCune JM, Nabel GJ, Ndung'u T, Pottage J, Ripin D, Rooney JF, Sikazwe I, Nsubuga M, Warren M, … -
The case for an HIV cure and how to get there.
The lancet. HIV 2020 Dybul M, Attoye T, Baptiste S, Cherutich P, Dabis F, Deeks SG, Dieffenbach C, Doehle B, Goodenow MM, Jiang A, Kemps D, Lewin SR, Lumpkin MM, Mathae L, McCune JM, Ndung'u T, Nsubuga M, Peay HL, Pottage… -
Bringing Gene Therapies for HIV Disease to Resource-Limited Parts of the World.
Human gene therapy 2020 McCune JM, Turner EH, Jiang A, Doehle BP -
Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities.
Annals of the rheumatic diseases 2020 Johnson SR, Brinks R, Costenbader KH, Daikh D, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, … -
Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.
Cell reports 2020 Cham LB, Torrez Dulgeroff LB, Tal MC, Adomati T, Li F, Bhat H, Huang A, Lang PA, Moreno ME, Rivera JM, Galkina SA, Kosikova G, Stoddart CA, McCune JM, Myers LM, Weissman IL, Lang KS, Hasenkrug KJ -
Why and where an HIV cure is needed and how it might be achieved.
Nature 2019 Ndung'u T, McCune JM, Deeks SG -
The Ban on US Government Funding Research Using Human Fetal Tissues: How Does This Fit with the NIH Mission to Advance Medical Science for the Benefit of the Citizenry?
Stem cell reports 2019 McCune JM, Weissman IL -
Some Aspects of CD8+ T-Cell Exhaustion Are Associated With Altered T-Cell Mitochondrial Features and ROS Content in HIV Infection.
Journal of acquired immune deficiency syndromes (1999) 2019 Deguit CDT, Hough M, Hoh R, Krone M, Pilcher CD, Martin JN, Deeks SG, McCune JM, Hunt PW, Rutishauser RL -
2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus.
Arthritis & rheumatology (Hoboken, N.J.) 2019 Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, … -
2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus.
Annals of the rheumatic diseases 2019 Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, … -
Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post-Combination Antiretroviral Therapy CD4+ T Cell Counts and Body Weight.
Journal of immunology (Baltimore, Md. : 1950) 2019 Swainson LA, Ahn H, Pajanirassa P, Khetarpal V, Deleage C, Estes JD, Hunt PW, Munoz-Sanjuan I, McCune JM -
CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals.
Pathogens & immunity 2019 Vásquez JJ, Aguilar-Rodriguez BL, Rodriguez L, Hogan LE, Somsouk M, McCune JM, Deeks SG, Laszik ZG, Hunt PW, Henrich TJ -
HIV "cure": A shot in the arm?
EBioMedicine 2019 Peluso MJ, Deeks SG, McCune JM -
Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans.
Human molecular genetics 2018 Hanscombe KB, Morris DL, Noble JA, Dilthey AT, Tombleson P, Kaufman KM, Comeau M, Langefeld CD, Alarcon-Riquelme ME, Gaffney PM, Jacob CO, Sivils KL, Tsao BP, Alarcon GS, Brown EE, Croker J, Edberg J,… -
A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function.
PLoS pathogens 2018 Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM -
Elucidating the Burden of HIV in Tissues Using Multiplexed Immunofluorescence and In Situ Hybridization: Methods for the Single-Cell Phenotypic Characterization of Cells Harboring HIV In Situ.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2018 Vasquez JJ, Hussien R, Aguilar-Rodriguez B, Junger H, Dobi D, Henrich TJ, Thanh C, Gibson E, Hogan LE, McCune J, Hunt PW, Stoddart CA, Laszik ZG -
Glut1 Expression Level on Inflammatory Monocytes is Associated With Markers of Cardiovascular Disease Risk in HIV-Infected Individuals.
Journal of acquired immune deficiency syndromes (1999) 2018 Anzinger JJ, Butterfield TR, Gouillou M, McCune JM, Crowe SM, Palmer CS -
Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success.
Journal of immunology (Baltimore, Md. : 1950) 2017 Méndez-Lagares G, Lu D, Chen C, Terrault N, Segal MR, Khalili M, Monto A, Shen H, Manos MM, Lanier LL, Ryan JC, McCune JM, Hartigan-O'Connor DJ -
HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.
PLoS medicine 2017 Henrich TJ, Hatano H, Bacon O, Hogan LE, Rutishauser R, Hill A, Kearney MF, Anderson EM, Buchbinder SP, Cohen SE, Abdel-Mohsen M, Pohlmeyer CW, Fromentin R, Hoh R, Liu AY, McCune JM, Spindler J, … -
IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8+ T Cell Responses in Acute Simian Immunodeficiency Virus Infection.
AIDS research and human retroviruses 2017 Méndez-Lagares G, Lu D, Merriam D, Baker CA, Villinger F, Van Rompay KKA, McCune JM, Hartigan-O'Connor DJ -
Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection.
FEBS letters 2017 Palmer CS, Duette GA, Wagner MCE, Henstridge DC, Saleh S, Pereira C, Zhou J, Simar D, Lewin SR, Ostrowski M, McCune JM, Crowe SM -
Defining total-body AIDS-virus burden with implications for curative strategies.
Nature medicine 2017 Estes JD, Kityo C, Ssali F, Swainson L, Makamdop KN, Del Prete GQ, Deeks SG, Luciw PA, Chipman JG, Beilman GJ, Hoskuldsson T, Khoruts A, Anderson J, Deleage C, Jasurda J, Schmidt TE, Hafertepe M, … -
Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells.
Cell reports 2017 Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer MH, Lazarus NH, Jones JJ, Ochsenbauer C, McCune JM, Butcher EC, Arvin AM, Sen N, Greene WC, Roan NR -
Transancestral mapping and genetic load in systemic lupus erythematosus.
Nature communications 2017 Langefeld CD, Ainsworth HC, Cunninghame Graham DS, Kelly JA, Comeau ME, Marion MC, Howard TD, Ramos PS, Croker JA, Morris DL, Sandling JK, Almlöf JC, Acevedo-Vásquez EM, Alarcón GS, Babini AM, Baca V,… -
Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals.
Gut microbes 2017 Vujkovic-Cvijin I, Rutishauser RL, Pao M, Hunt PW, Lynch SV, McCune JM, Somsouk M -
Early and Delayed Antiretroviral Therapy Results in Comparable Reductions in CD8+ T Cell Exhaustion Marker Expression.
AIDS research and human retroviruses 2017 Rutishauser RL, Hartogensis W, Deguit CD, Krone M, Hoh R, Hecht FM, Pilcher CD, Bacchetti P, Deeks SG, Hunt PW, McCune JM -
Relative mRNA Expression Levels of Restriction Factors and Antiviral Genes in Fetal and Adult Human Monocytes and Monocyte-Derived Macrophages.
Viral immunology 2017 Trang K, Raposo RA, Lowe MM, Krow-Lucal ER, Yonemoto W, Cabido VD, SenGupta D, McCune JM -
Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-β Signaling.
Journal of immunology (Baltimore, Md. : 1950) 2016 Bronevetsky Y, Burt TD, McCune JM -
MR Diffusion Tractography to Identify and Characterize Microstructural White Matter Tract Changes in Systemic Lupus Erythematosus Patients.
Academic radiology 2016 Shastri R, Shah G, Wang P, Cagnoli P, Schmidt-Wilcke T, McCune J, Harris R, Sundgren P -
Henry Kunkel and the teaching of patient-oriented research.
Clinical immunology (Orlando, Fla.) 2016 McCune JM -
A Simple Flow Cytometric Method to Measure Glucose Uptake and Glucose Transporter Expression for Monocyte Subpopulations in Whole Blood.
Journal of visualized experiments : JoVE 2016 Palmer CS, Anzinger JJ, Butterfield TR, McCune JM, Crowe SM -
International AIDS Society global scientific strategy: towards an HIV cure 2016.
Nature medicine 2016 Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, International AIDS… -
Impact of early cART in the gut during acute HIV infection.
JCI insight 2016 Deleage C, Schuetz A, Alvord WG, Johnston L, Hao XP, Morcock DR, Rerknimitr R, Fletcher JL, Puttamaswin S, Phanuphak N, Dewar R, McCune JM, Sereti I, Robb M, Kim JH, Schacker TW, Hunt P, Lifson JD, … -
Colony-Stimulating Factor 1 Receptor Antagonists Sensitize Human Immunodeficiency Virus Type 1-Infected Macrophages to TRAIL-Mediated Killing.
Journal of virology 2016 Cunyat F, Rainho JN, West B, Swainson L, McCune JM, Stevenson M -
IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection.
The Journal of clinical investigation 2016 Younes SA, Freeman ML, Mudd JC, Shive CL, Reynaldi A, Panigrahi S, Estes JD, Deleage C, Lucero C, Anderson J, Schacker TW, Davenport MP, McCune JM, Hunt PW, Lee SA, Serrano-Villar S, Debernardo RL, … -
Immunologic profiles distinguish aviremic HIV-infected adults.
AIDS (London, England) 2016 Ramirez CM, Sinclair E, Epling L, Lee SA, Jain V, Hsue PY, Hatano H, Conn D, Hecht FM, Martin JN, McCune JM, Deeks SG, Hunt PW -
Eye examination for early diagnosis of disseminated tuberculosis in patients with AIDS.
The Lancet. Infectious diseases 2016 Heiden D, Saranchuk P, Keenan JD, Ford N, Lowinger A, Yen M, McCune J, Rao NA -
A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?
Pathogens & immunity 2016 Lederman MM, Cannon PM, Currier JS, June CH, Kiem HP, Kuritzkes DR, Lewin SR, Margolis DM, McCune JM, Mellors JW, Schacker TW, Sekaly RP, Tebas P, Walker BD, Douek DC -
Defining HIV and SIV Reservoirs in Lymphoid Tissues.
Pathogens & immunity 2016 Deleage C, Wietgrefe SW, Del Prete G, Morcock DR, Hao XP, Piatak M, Bess J, Anderson JL, Perkey KE, Reilly C, McCune JM, Haase AT, Lifson JD, Schacker TW, Estes JD -
Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques.
Cell reports 2015 Vujkovic-Cvijin I, Swainson LA, Chu SN, Ortiz AM, Santee CA, Petriello A, Dunham RM, Fadrosh DW, Lin DL, Faruqi AA, Huang Y, Apetrei C, Pandrea I, Hecht FM, Pilcher CD, Klatt NR, Brenchley JM, Lynch … -
Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1β: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease.
Journal of immunology (Baltimore, Md. : 1950) 2015 Ladell K, Hazenberg MD, Fitch M, Emson C, McEvoy-Hein Asgarian BK, Mold JE, Miller C, Busch R, Price DA, Hellerstein MK, McCune JM -
IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques.
Mucosal immunology 2015 Ortiz AM, Klase ZA, DiNapoli SR, Vujkovic-Cvijin I, Carmack K, Perkins MR, Calantone N, Vinton CL, Riddick NE, Gallagher J, Klatt NR, McCune JM, Estes JD, Paiardini M, Brenchley JM -
Exposure to SIV in utero results in reduced viral loads and altered responsiveness to postnatal challenge.
Science translational medicine 2015 Baker CA, Swainson L, Lin DL, Wong S, Hartigan-O'Connor DJ, Lifson JD, Tarantal AF, McCune JM -
Immune mechanisms at the maternal-fetal interface: perspectives and challenges.
Nature immunology 2015 PrabhuDas M, Bonney E, Caron K, Dey S, Erlebacher A, Fazleabas A, Fisher S, Golos T, Matzuk M, McCune JM, Mor G, Schulz L, Soares M, Spencer T, Strominger J, Way SS, Yoshinaga K -
Gut epithelial barrier and systemic inflammation during chronic HIV infection.
AIDS (London, England) 2015 Somsouk M, Estes JD, Deleage C, Dunham RM, Albright R, Inadomi JM, Martin JN, Deeks SG, McCune JM, Hunt PW -
Glucocorticoid treatment at moderate doses of SIVmac251-infected rhesus macaques decreases the frequency of circulating CD14+CD16++ monocytes but does not alter the tissue virus reservoir.
AIDS research and human retroviruses 2015 Moniuszko M, Liyanage NP, Doster MN, Parks RW, Grubczak K, Lipinska D, McKinnon K, Brown C, Hirsch V, Vaccari M, Gordon S, Pegu P, Fenizia C, Flisiak R, Grzeszczuk A, Dabrowska M, Robert-Guroff M, … -
The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized crossover trial.
PloS one 2014 Somsouk M, Dunham RM, Cohen M, Albright R, Abdel-Mohsen M, Liegler T, Lifson J, Piatak M, Gorelick R, Huang Y, Wu Y, Hsue PY, Martin JN, Deeks SG, McCune JM, Hunt PW -
Glucose transporter 1-expressing proinflammatory monocytes are elevated in combination antiretroviral therapy-treated and untreated HIV+ subjects.
Journal of immunology (Baltimore, Md. : 1950) 2014 Palmer CS, Anzinger JJ, Zhou J, Gouillou M, Landay A, Jaworowski A, McCune JM, Crowe SM -
Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4(+) T cell recovery after the initiation of antiretroviral therapy for HIV disease.
AIDS research and therapy 2014 Seu L, Ortiz GM, Burt TD, Deeks SG, Martin JN, McCune JM -
Programmed death-1 expression on CD4⁺ and CD8⁺ T cells in treated and untreated HIV disease.
AIDS (London, England) 2014 Cockerham LR, Jain V, Sinclair E, Glidden DV, Hartogenesis W, Hatano H, Hunt PW, Martin JN, Pilcher CD, Sekaly R, McCune JM, Hecht FM, Deeks SG -
Distinct functional programs in fetal T and myeloid lineages.
Frontiers in immunology 2014 Krow-Lucal ER, McCune JM -
Myeloid-lymphoid ontogeny in the rhesus monkey (Macaca mulatta).
Anatomical record (Hoboken, N.J. : 2007) 2014 Batchelder CA, Duru N, Lee CI, Baker CA, Swainson L, Mccune JM, Tarantal AF -
HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.
PLoS pathogens 2014 Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, … -
Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection.
The Journal of infectious diseases 2014 Lee SA, Sinclair E, Jain V, Huang Y, Epling L, Van Natta M, Meinert CL, Martin JN, McCune JM, Deeks SG, Lederman MM, Hecht FM, Hunt PW -
The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy.
The Journal of infectious diseases 2014 Byakwaga H, Boum Y, Huang Y, Muzoora C, Kembabazi A, Weiser SD, Bennett J, Cao H, Haberer JE, Deeks SG, Bangsberg DR, McCune JM, Martin JN, Hunt PW -
Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging.
PloS one 2014 Lee SA, Sinclair E, Hatano H, Hsue PY, Epling L, Hecht FM, Bangsberg DR, Martin JN, McCune JM, Deeks SG, Hunt PW -
Distinct functional programming of human fetal and adult monocytes.
Blood 2014 Krow-Lucal ER, Kim CC, Burt TD, McCune JM -
Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.
PloS one 2014 Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger J, Sherr DH, Silverstone AE, Hahn ME, McCune JM -
Discordance between peripheral and colonic markers of inflammation during suppressive ART.
Journal of acquired immune deficiency syndromes (1999) 2014 Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM -
Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection.
AIDS (London, England) 2014 Palmer CS, Ostrowski M, Gouillou M, Tsai L, Yu D, Zhou J, Henstridge DC, Maisa A, Hearps AC, Lewin SR, Landay A, Jaworowski A, McCune JM, Crowe SM -
Composition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease.
PloS one 2014 Emu B, Moretto WJ, Hoh R, Krone M, Martin JN, Nixon DF, Deeks SG, McCune JM -
Analysis of maternal microchimerism in rhesus monkeys (Macaca mulatta) using real-time quantitative PCR amplification of MHC polymorphisms.
Chimerism 2014 Bakkour S, Baker CA, Tarantal AF, Wen L, Busch MP, Lee TH, McCune JM -
Higher CD27+CD8+ T cells percentages during suppressive antiretroviral therapy predict greater subsequent CD4+ T cell recovery in treated HIV infection.
PloS one 2013 Seu L, Ortiz GM, Epling L, Sinclair E, Swainson LA, Bajpai UD, Huang Y, Deeks SG, Hunt PW, Martin JN, McCune JM -
Monocyte activation by interferon α is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection.
The Journal of infectious diseases 2013 Hartigan-O'Connor DJ, Lin D, Ryan JC, Shvachko VA, Cozen ML, Segal MR, Terrault NA, Lanier LL, Manos MM, McCune JM -
Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers.
PLoS pathogens 2013 Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, … -
Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial.
The Journal of infectious diseases 2013 Hatano H, Strain MC, Scherzer R, Bacchetti P, Wentworth D, Hoh R, Martin JN, McCune JM, Neaton JD, Tracy RP, Hsue PY, Richman DD, Deeks SG -
Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size.
The Journal of infectious diseases 2013 Jain V, Hartogensis W, Bacchetti P, Hunt PW, Hatano H, Sinclair E, Epling L, Lee TH, Busch MP, McCune JM, Pilcher CD, Hecht FM, Deeks SG -
Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism.
Science translational medicine 2013 Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM -
IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.
International immunology 2013 Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM -
Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon.
PLoS pathogens 2012 Broadhurst MJ, Ardeshir A, Kanwar B, Mirpuri J, Gundra UM, Leung JM, Wiens KE, Vujkovic-Cvijin I, Kim CC, Yarovinsky F, Lerche NW, McCune JM, Loke P -
Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells.
The Journal of infectious diseases 2012 Hatano H, Jain V, Hunt PW, Lee TH, Sinclair E, Do TD, Hoh R, Martin JN, McCune JM, Hecht F, Busch MP, Deeks SG -
Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase.
AIDS research and human retroviruses 2012 Dunham RM, Gordon SN, Vaccari M, Piatak M, Huang Y, Deeks SG, Lifson J, Franchini G, McCune JM -
Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.
PLoS pathogens 2012 Broadhurst MJ, Leung JM, Lim KC, Girgis NM, Gundra UM, Fallon PG, Premenko-Lanier M, McKerrow JH, McCune JM, Loke P -
A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity.
Arthritis and rheumatism 2012 Bajpai UD, Swainson LA, Mold JE, Graf JD, Imboden JB, McCune JM -
Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus.
Arthritis research & therapy 2012 Sacre K, Criswell LA, McCune JM -
Immunosenescence and HIV.
Current opinion in immunology 2012 Deeks SG, Verdin E, McCune JM -
SIV replication in the infected rhesus macaque is limited by the size of the preexisting TH17 cell compartment.
Science translational medicine 2012 Hartigan-O'Connor DJ, Abel K, Van Rompay KK, Kanwar B, McCune JM -
Morphine produces immunosuppressive effects in nonhuman primates at the proteomic and cellular levels.
Molecular & cellular proteomics : MCP 2012 Brown JN, Ortiz GM, Angel TE, Jacobs JM, Gritsenko M, Chan EY, Purdy DE, Murnane RD, Larsen K, Palermo RE, Shukla AK, Clauss TR, Katze MG, McCune JM, Smith RD -
A role for cytomegalovirus-specific CD4+CX3CR1+ T cells and cytomegalovirus-induced T-cell immunopathology in HIV-associated atherosclerosis.
AIDS (London, England) 2012 Sacre K, Hunt PW, Hsue PY, Maidji E, Martin JN, Deeks SG, Autran B, McCune JM -
Blood T-cell receptor diversity decreases during the course of HIV infection, but the potential for a diverse repertoire persists.
Blood 2012 Baum PD, Young JJ, Schmidt D, Zhang Q, Hoh R, Busch M, Martin J, Deeks S, McCune JM -
Hematopoietic-stem-cell-based gene therapy for HIV disease.
Cell stem cell 2012 Kiem HP, Jerome KR, Deeks SG, McCune JM -
Immunological tolerance during fetal development: from mouse to man.
Advances in immunology 2012 Mold JE, McCune JM -
Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase.
AIDS (London, England) 2011 Baum PD, Sullam PM, Stoddart CA, McCune JM -
Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans.
Genes and immunity 2011 Seu L, Burt TD, Witte JS, Martin JN, Deeks SG, McCune JM -
Immune activation, CD4+ T cell counts, and viremia exhibit oscillatory patterns over time in patients with highly resistant HIV infection.
PloS one 2011 Kitchen CM, Yeghiazarian L, Hoh R, McCune JM, Sinclair E, Martin JN, Deeks SG -
Breaking free of sample size dogma to perform innovative translational research.
Science translational medicine 2011 Bacchetti P, Deeks SG, McCune JM -
Th17 cells and regulatory T cells in elite control over HIV and SIV.
Current opinion in HIV and AIDS 2011 Hartigan-O'Connor DJ, Hirao LA, McCune JM, Dandekar S -
A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response.
The Journal of infectious diseases 2011 Hatano H, Hayes TL, Dahl V, Sinclair E, Lee TH, Hoh R, Lampiris H, Hunt PW, Palmer S, McCune JM, Martin JN, Busch MP, Shacklett BL, Deeks SG -
At the crossroads between tolerance and aggression: Revisiting the "layered immune system" hypothesis.
Chimerism 2011 Mold JE, McCune JM -
Measurement of absolute T cell receptor rearrangement diversity.
Journal of immunological methods 2011 Baum PD, Young JJ, McCune JM -
A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers.
PloS one 2011 Hunt PW, Landay AL, Sinclair E, Martinson JA, Hatano H, Emu B, Norris PJ, Busch MP, Martin JN, Brooks C, McCune JM, Deeks SG -
HIV-specific CD4+ T cells may contribute to viral persistence in HIV controllers.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011 Hunt PW, Hatano H, Sinclair E, Lee TH, Busch MP, Martin JN, McCune JM, Deeks SG -
The human fetal immune response to hepatitis C virus exposure in utero.
The Journal of infectious diseases 2011 Babik JM, Cohan D, Monto A, Hartigan-O'Connor DJ, McCune JM -
HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cells.
Blood 2011 Favre D, Stoddart CA, Emu B, Hoh R, Martin JN, Hecht FM, Deeks SG, McCune JM -
Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans.
Science (New York, N.Y.) 2010 Mold JE, Venkatasubrahmanyam S, Burt TD, Michaëlsson J, Rivera JM, Galkina SA, Weinberg K, Stoddart CA, McCune JM -
IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient.
Science translational medicine 2010 Broadhurst MJ, Leung JM, Kashyap V, McCune JM, Mahadevan U, McKerrow JH, Loke P -
Design, construction, and validation of a modular library of sequence diversity standards for polymerase chain reaction.
Analytical biochemistry 2010 Baum PD, Young JJ, Zhang Q, Kasakow Z, McCune JM -
Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin.
Journal of immunology (Baltimore, Md. : 1950) 2010 Burt TD, Seu L, Mold JE, Kappas A, McCune JM -
The role of transplacental microtransfusions of maternal lymphocytes in in utero HIV transmission.
Journal of acquired immune deficiency syndromes (1999) 2010 Lee TH, Chafets DM, Biggar RJ, McCune JM, Busch MP -
Can HIV be cured with stem cell therapy?
Nature biotechnology 2010 Deeks SG, McCune JM -
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.
Science translational medicine 2010 Favre D, Mold J, Hunt PW, Kanwar B, Loke P, Seu L, Barbour JD, Lowe MM, Jayawardene A, Aweeka F, Huang Y, Douek DC, Brenchley JM, Martin JN, Hecht FM, Deeks SG, McCune JM -
Th17 and regulatory T cells: implications for AIDS pathogenesis.
Current opinion in HIV and AIDS 2010 Kanwar B, Favre D, McCune JM -
Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1.
Journal of immunology (Baltimore, Md. : 1950) 2010 Swainson LA, Mold JE, Bajpai UD, McCune JM -
IFN-alpha-induced upregulation of CCR5 leads to expanded HIV tropism in vivo.
PLoS pathogens 2010 Stoddart CA, Keir ME, McCune JM -
Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers.
Blood 2010 Loke P, Favre D, Hunt PW, Leung JM, Kanwar B, Martin JN, Deeks SG, McCune JM -
Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease.
PloS one 2010 Naeger DM, Martin JN, Sinclair E, Hunt PW, Bangsberg DR, Hecht F, Hsue P, McCune JM, Deeks SG -
Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome.
Clinical immunology (Orlando, Fla.) 2009 Cheng LE, Kanwar B, Tcheurekdjian H, Grenert JP, Muskat M, Heyman MB, McCune JM, Wara DW -
Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.
PLoS pathogens 2009 Favre D, Lederer S, Kanwar B, Ma ZM, Proll S, Kasakow Z, Mold J, Swainson L, Barbour JD, Baskin CR, Palermo R, Pandrea I, Miller CJ, Katze MG, McCune JM -
Transcriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization.
PLoS pathogens 2009 Lederer S, Favre D, Walters KA, Proll S, Kanwar B, Kasakow Z, Baskin CR, Palermo R, McCune JM, Katze MG -
Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells.
The Journal of biological chemistry 2009 Contreras X, Schweneker M, Chen CS, McCune JM, Deeks SG, Martin J, Peterlin BM -
Gag p27-specific B- and T-cell responses in Simian immunodeficiency virus SIVagm-infected African green monkeys.
Journal of virology 2008 Lozano Reina JM, Favre D, Kasakow Z, Mayau V, Nugeyre MT, Ka T, Faye A, Miller CJ, Scott-Algara D, McCune JM, Barré-Sinoussi F, Diop OM, Müller-Trutwin MC -
Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero.
Science (New York, N.Y.) 2008 Mold JE, Michaëlsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, Lee TH, Nixon DF, McCune JM -
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection.
The Journal of experimental medicine 2008 Jones RB, Ndhlovu LC, Barbour JD, Sheth PM, Jha AR, Long BR, Wong JC, Satkunarajah M, Schweneker M, Chapman JM, Gyenes G, Vali B, Hyrcza MD, Yue FY, Kovacs C, Sassi A, Loutfy M, Halpenny R, Persad D, … -
Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy.
Journal of virology 2008 Hatano H, Delwart EL, Norris PJ, Lee TH, Dunn-Williams J, Hunt PW, Hoh R, Stramer SL, Linnen JM, McCune JM, Martin JN, Busch MP, Deeks SG -
Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.
Proceedings of the National Academy of Sciences of the United States of America 2008 Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK -
Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression.
Journal of immunology (Baltimore, Md. : 1950) 2008 Ladell K, Hellerstein MK, Cesar D, Busch R, Boban D, McCune JM -
HIV-induced changes in T cell signaling pathways.
Journal of immunology (Baltimore, Md. : 1950) 2008 Schweneker M, Favre D, Martin JN, Deeks SG, McCune JM -
HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control.
Journal of virology 2008 Emu B, Sinclair E, Hatano H, Ferre A, Shacklett B, Martin JN, McCune JM, Deeks SG -
Growth hormone enhances thymic function in HIV-1-infected adults.
The Journal of clinical investigation 2008 Napolitano LA, Schmidt D, Gotway MB, Ameli N, Filbert EL, Ng MM, Clor JL, Epling L, Sinclair E, Baum PD, Li K, Killian ML, Bacchetti P, McCune JM -
Effect of SIVmac infection on plasmacytoid and CD1c+ myeloid dendritic cells in cynomolgus macaques.
Immunology 2008 Malleret B, Karlsson I, Manéglier B, Brochard P, Delache B, Andrieu T, Muller-Trutwin M, Beaumont T, McCune JM, Banchereau J, Le Grand R, Vaslin B -
Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy.
The Journal of infectious diseases 2008 Hunt PW, Brenchley J, Sinclair E, McCune JM, Roland M, Page-Shafer K, Hsue P, Emu B, Krone M, Lampiris H, Douek D, Martin JN, Deeks SG -
HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007 Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM, Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune … -
Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression.
The Journal of experimental medicine 2007 Hartigan-O'Connor DJ, Abel K, McCune JM -
In vivo imaging of mucosal CD4+ T cells using single photon emission computed tomography in a murine model of colitis.
Journal of immunological methods 2007 Kanwar B, Gao DW, Hwang AB, Grenert JP, Williams SP, Franc B, McCune JM -
Loss of T cell responses following long-term cryopreservation.
Journal of immunological methods 2007 Owen RE, Sinclair E, Emu B, Heitman JW, Hirschkorn DF, Epling CL, Tan QX, Custer B, Harris JM, Jacobson MA, McCune JM, Martin JN, Hecht FM, Deeks SG, Norris PJ -
Antiviral antibodies are necessary for control of simian immunodeficiency virus replication.
Journal of virology 2007 Miller CJ, Genescà M, Abel K, Montefiori D, Forthal D, Bost K, Li J, Favre D, McCune JM -
Dehydroepiandrosterone (DHEA) effects on HIV replication and host immunity: a randomized placebo-controlled study.
AIDS research and human retroviruses 2007 Abrams DI, Shade SB, Couey P, McCune JM, Lo J, Bacchetti P, Chang B, Epling L, Liegler T, Grant RM -
Increased carotid intima-media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses.
AIDS (London, England) 2006 Hsue PY, Hunt PW, Sinclair E, Bredt B, Franklin A, Killian M, Hoh R, Martin JN, McCune JM, Waters DD, Deeks SG -
Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells.
Journal of immunological methods 2006 Hartigan-O'Connor DJ, Poon C, Sinclair E, McCune JM -
Direct measurement of T-cell receptor repertoire diversity with AmpliCot.
Nature methods 2006 Baum PD, McCune JM -
A plea for justice for jailed medical workers.
Science (New York, N.Y.) 2006 Ahuja SK, Aiuti F, Berkhout B, Biberfeld P, Burton DR, Colizzi V, Deeks SG, Desrosiers RC, Dierich MP, Doms RW, Emerman M, Gallo RC, Girard M, Greene WC, Hoxie JA, Hunter E, Klein G, Korber B, … -
Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.
The Journal of clinical investigation 2006 Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ -
Prevalence of CXCR4 tropism among antiretroviral-treated HIV-1-infected patients with detectable viremia.
The Journal of infectious diseases 2006 Hunt PW, Harrigan PR, Huang W, Bates M, Williamson DW, McCune JM, Price RW, Spudich SS, Lampiris H, Hoh R, Leigler T, Martin JN, Deeks SG -
IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells.
AIDS research and therapy 2006 Nomura LE, Emu B, Hoh R, Haaland P, Deeks SG, Martin JN, McCune JM, Nixon DF, Maecker HT -
Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses.
Journal of virology 2006 Deeks SG, Schweighardt B, Wrin T, Galovich J, Hoh R, Sinclair E, Hunt P, McCune JM, Martin JN, Petropoulos CJ, Hecht FM -
Regulation of T cell responses in the developing human fetus.
Journal of immunology (Baltimore, Md. : 1950) 2006 Michaëlsson J, Mold JE, McCune JM, Nixon DF -
HIV-1-specific CD4+ T cell responses in chronically HIV-1 infected blippers on antiretroviral therapy in relation to viral replication following treatment interruption.
Journal of clinical immunology 2006 Papasavvas E, Kostman JR, Thiel B, Pistilli M, Mackiewicz A, Foulkes A, Gross R, Jordan KA, Nixon DF, Grant R, Poulin JF, McCune JM, Mounzer K, Montaner LJ -
Literature watch. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.
Lymphatic research and biology 2006 Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ -
Increased circulating interleukin-7 levels in HIV-1-infected women.
Journal of acquired immune deficiency syndromes (1999) 2005 Napolitano LA, Burt TD, Bacchetti P, Barrón Y, French AL, Kovacs A, Anastos K, Young M, McCune JM, Greenblatt RM -
Enhanced replication of R5 HIV-1 over X4 HIV-1 in CD4(+)CCR5(+)CXCR4(+) T cells.
Journal of acquired immune deficiency syndromes (1999) 2005 Roy AM, Schweighardt B, Eckstein LA, Goldsmith MA, McCune JM -
Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment.
Journal of virology 2005 Emu B, Sinclair E, Favre D, Moretto WJ, Hsue P, Hoh R, Martin JN, Nixon DF, McCune JM, Deeks SG -
Growth hormone-induced stimulation of multilineage human hematopoiesis.
Stem cells (Dayton, Ohio) 2005 Hanley MB, Napolitano LA, McCune JM -
Multiparameter evaluation of human thymic function: interpretations and caveats.
Clinical immunology (Orlando, Fla.) 2005 Harris JM, Hazenberg MD, Poulin JF, Higuera-Alhino D, Schmidt D, Gotway M, McCune JM -
A serum proteomic approach to gauging the state of remission in Wegener's granulomatosis.
Arthritis and rheumatism 2005 Stone JH, Rajapakse VN, Hoffman GS, Specks U, Merkel PA, Spiera RF, Davis JC, St Clair EW, McCune J, Ross S, Hitt BA, Veenstra TD, Conrads TP, Liotta LA, Petricoin EF, Wegener's Granulomatosis … -
Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy.
AIDS (London, England) 2004 Smith K, Aga E, Bosch RJ, Valdez H, Connick E, Landay A, Kuritzkes D, Gross BH, Francis IR, McCune JM, Kessler H, Lederman M -
Gene expression profiles during human CD4+ T cell differentiation.
International immunology 2004 Lee MS, Hanspers K, Barker CS, Korn AP, McCune JM -
Isolation of peripheral blood CD4(+) T cells using RosetteSep and MACS for studies of DNA turnover by deuterium labeling.
Journal of immunological methods 2004 Busch R, Cesar D, Higuera-Alhino D, Gee T, Hellerstein MK, McCune JM -
Public health. A sound rationale needed for phase III HIV-1 vaccine trials.
Science (New York, N.Y.) 2004 Burton DR, Desrosiers RC, Doms RW, Feinberg MB, Gallo RC, Hahn B, Hoxie JA, Hunter E, Korber B, Landay A, Lederman MM, Lieberman J, McCune JM, Moore JP, Nathanson N, Picker L, Richman D, Rinaldo C, … -
Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1.
The Journal of infectious diseases 2004 Deeks SG, Martin JN, Sinclair E, Harris J, Neilands TB, Maecker HT, Hagos E, Wrin T, Petropoulos CJ, Bredt B, McCune JM -
Comparison of the ELISPOT and cytokine flow cytometry assays for the enumeration of antigen-specific T cells.
Journal of immunological methods 2003 Karlsson AC, Martin JN, Younger SR, Bredt BM, Epling L, Ronquillo R, Varma A, Deeks SG, McCune JM, Nixon DF, Sinclair E -
Value of MRI of the brain in patients with systemic lupus erythematosus and neurologic disturbance.
Neuroradiology 2003 Jennings JE, Sundgren PC, Attwood J, McCune J, Maly P -
Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection.
The Journal of clinical investigation 2003 Hellerstein MK, Hoh RA, Hanley MB, Cesar D, Lee D, Neese RA, McCune JM -
Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial.
Annals of internal medicine 2003 Abrams DI, Hilton JF, Leiser RJ, Shade SB, Elbeik TA, Aweeka FT, Benowitz NL, Bredt BM, Kosel B, Aberg JA, Deeks SG, Mitchell TF, Mulligan K, Bacchetti P, McCune JM, Schambelan M -
Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice.
Journal of immunology (Baltimore, Md. : 1950) 2003 Napolitano LA, Stoddart CA, Hanley MB, Wieder E, McCune JM -
Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis.
Journal of virology 2003 Stoddart CA, Geleziunas R, Ferrell S, Linquist-Stepps V, Moreno ME, Bare C, Xu W, Yonemoto W, Bresnahan PA, McCune JM, Greene WC -
Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA.
Proceedings of the National Academy of Sciences of the United States of America 2002 Neese RA, Misell LM, Turner S, Chu A, Kim J, Cesar D, Hoh R, Antelo F, Strawford A, McCune JM, Christiansen M, Hellerstein MK -
Short-term effects of cannabinoids on immune phenotype and function in HIV-1-infected patients.
Journal of clinical pharmacology 2002 Bredt BM, Higuera-Alhino D, Shade SB, Hebert SJ, McCune JM, Abrams DI -
HIV tropism and CD4+ T-cell depletion.
Nature medicine 2002 Feinberg MB, McCune JM, Miedema F, Moore JP, Schuitemaker H -
Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone.
AIDS (London, England) 2002 Napolitano LA, Lo JC, Gotway MB, Mulligan K, Barbour JD, Schmidt D, Grant RM, Halvorsen RA, Schambelan M, McCune JM -
CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy.
The Journal of infectious diseases 2002 Deeks SG, Hoh R, Grant RM, Wrin T, Barbour JD, Narvaez A, Cesar D, Abe K, Hanley MB, Hellmann NS, Petropoulos CJ, McCune JM, Hellerstein MK -
IFN-alpha secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus.
Journal of immunology (Baltimore, Md. : 1950) 2002 Keir ME, Stoddart CA, Linquist-Stepps V, Moreno ME, McCune JM -
Use of overlapping peptide mixtures as antigens for cytokine flow cytometry.
Journal of immunological methods 2001 Maecker HT, Dunn HS, Suni MA, Khatamzas E, Pitcher CJ, Bunde T, Persaud N, Trigona W, Fu TM, Sinclair E, Bredt BM, McCune JM, Maino VC, Kern F, Picker LJ -
Impaired replication of protease inhibitor-resistant HIV-1 in human thymus.
Nature medicine 2001 Stoddart CA, Liegler TJ, Mammano F, Linquist-Stepps VD, Hayden MS, Deeks SG, Grant RM, Clavel F, McCune JM -
The dynamics of CD4+ T-cell depletion in HIV disease.
Nature 2001 McCune JM -
Cytomegalovirus (CMV)-specific CD4+ T lymphocyte immune function in long-term survivors of AIDS-related CMV end-organ disease who are receiving potent antiretroviral therapy.
The Journal of infectious diseases 2001 Jacobson MA, Schrier R, McCune JM, Torriani FJ, Holland GN, O'Donnell JJ, Freeman WR, Bredt BM -
Loss of cytomegalovirus-specific CD4+ T cell responses in human immunodeficiency virus type 1-infected patients with high CD4+ T cell counts and recurrent retinitis.
The Journal of infectious diseases 2001 Komanduri KV, Feinberg J, Hutchins RK, Frame RD, Schmidt DK, Viswanathan MN, Lalezari JP, McCune JM -
Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia.
The New England journal of medicine 2001 Deeks SG, Wrin T, Liegler T, Hoh R, Hayden M, Barbour JD, Hellmann NS, Petropoulos CJ, McCune JM, Hellerstein MK, Grant RM -
Direct measurement of CD4+ and CD8+ T-cell responses to CMV in HIV-1-infected subjects.
Virology 2001 Komanduri KV, Donahoe SM, Moretto WJ, Schmidt DK, Gillespie G, Ogg GS, Roederer M, Nixon DF, McCune JM -
The diversity of T cells.
The New England journal of medicine 2001 Komanduri KV, McCune JM -
Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis.
Nature medicine 2001 Napolitano LA, Grant RM, Deeks SG, Schmidt D, De Rosa SC, Herzenberg LA, Herndier BG, Andersson J, McCune JM -
Coinfection of SCID-hu Thy/Liv mice with human herpesvirus 6 and human immunodeficiency virus type 1.
Journal of virology 2000 Gobbi A, Stoddart CA, Locatelli G, Santoro F, Bare C, Linquist-Stepps V, Moreno ME, Abbey NW, Herndier BG, Malnati MS, McCune JM, Lusso P -
Causal relationships between HIV-1 coreceptor utilization, tropism, and pathogenesis in human thymus.
AIDS research and human retroviruses 2000 Berkowitz RD, Alexander S, McCune JM -
Successful allogeneic bone marrow transplant in an HIV-1-positive man with chronic myelogenous leukemia.
Journal of acquired immune deficiency syndromes (1999) 2000 Schlegel P, Beatty P, Halvorsen R, McCune J -
A membrane-bound Fas decoy receptor expressed by human thymocytes.
The Journal of biological chemistry 2000 Jenkins M, Keir M, McCune JM -
Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice.
Antimicrobial agents and chemotherapy 2000 Stoddart CA, Moreno ME, Linquist-Stepps VD, Bare C, Bogan MR, Gobbi A, Buckheit RW, Bedard J, Rando RF, McCune JM -
Factors influencing T-cell turnover in HIV-1-seropositive patients.
The Journal of clinical investigation 2000 McCune JM, Hanley MB, Cesar D, Halvorsen R, Hoh R, Schmidt D, Wieder E, Deeks S, Siler S, Neese R, Hellerstein M -
Reversal of human immunodeficiency virus type 1-associated hematosuppression by effective antiretroviral therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000 Huang SS, Barbour JD, Deeks SG, Huang JS, Grant RM, Ng VL, McCune JM -
Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy.
The Journal of infectious diseases 2000 Smith KY, Valdez H, Landay A, Spritzler J, Kessler HA, Connick E, Kuritzkes D, Gross B, Francis I, McCune JM, Lederman MM -
Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice.
The Journal of experimental medicine 1999 Dittmer D, Stoddart C, Renne R, Linquist-Stepps V, Moreno ME, Bare C, McCune JM, Ganem D -
R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus.
Journal of virology 1999 Berkowitz RD, van't Wout AB, Kootstra NA, Moreno ME, Linquist-Stepps VD, Bare C, Stoddart CA, Schuitemaker H, McCune JM -
Direct evidence for thymic function in adult humans.
The Journal of experimental medicine 1999 Poulin JF, Viswanathan MN, Harris JM, Komanduri KV, Wieder E, Ringuette N, Jenkins M, McCune JM, Sékaly RP -
Fas is expressed early in human thymocyte development but does not transmit an apoptotic signal.
Journal of immunology (Baltimore, Md. : 1950) 1999 Jenkins M, Keir M, McCune JM -
Human herpesvirus 6 (HHV-6) causes severe thymocyte depletion in SCID-hu Thy/Liv mice.
The Journal of experimental medicine 1999 Gobbi A, Stoddart CA, Malnati MS, Locatelli G, Santoro F, Abbey NW, Bare C, Linquist-Stepps V, Moreno MB, Herndier BG, Lusso P, McCune JM -
Induction of MHC class I expression on immature thymocytes in HIV-1-infected SCID-hu Thy/Liv mice: evidence of indirect mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 1999 Kovalev G, Duus K, Wang L, Lee R, Bonyhadi M, Ho D, McCune JM, Kaneshima H, Su L -
Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans.
Nature medicine 1999 Hellerstein M, Hanley MB, Cesar D, Siler S, Papageorgopoulos C, Wieder E, Schmidt D, Hoh R, Neese R, Macallan D, Deeks S, McCune JM -
CCR5- and CXCR4-utilizing strains of human immunodeficiency virus type 1 exhibit differential tropism and pathogenesis in vivo.
Journal of virology 1998 Berkowitz RD, Alexander S, Bare C, Linquist-Stepps V, Bogan M, Moreno ME, Gibson L, Wieder ED, Kosek J, Stoddart CA, McCune JM -
CXCR4 and CCR5 expression delineates targets for HIV-1 disruption of T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1998 Berkowitz RD, Beckerman KP, Schall TJ, McCune JM -
Inhibition of human immunodeficiency virus type 1 infection in SCID-hu Thy/Liv mice by the G-quartet-forming oligonucleotide, ISIS 5320.
Antimicrobial agents and chemotherapy 1998 Stoddart CA, Rabin L, Hincenbergs M, Moreno M, Linquist-Stepps V, Leeds JM, Truong LA, Wyatt JR, Ecker DJ, McCune JM -
Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1.
Nature medicine 1998 Komanduri KV, Viswanathan MN, Wieder ED, Schmidt DK, Bredt BM, Jacobson MA, McCune JM -
High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection.
The Journal of clinical investigation 1998 McCune JM, Loftus R, Schmidt DK, Carroll P, Webster D, Swor-Yim LB, Francis IR, Gross BH, Grant RM -
Human immunodeficiency virus-1 infection interrupts thymopoiesis and multilineage hematopoiesis in vivo.
Blood 1998 Jenkins M, Hanley MB, Moreno MB, Wieder E, McCune JM -
Furry flasks?
Nature biotechnology 1998 Namikawa R, Kaneshima H, McCune JM -
UV irradiation of polystyrene pipets releases PCR inhibitors.
BioTechniques 1998 Linquist V, Stoddart CA, McCune JM -
Animal models of HIV-1 disease.
Science (New York, N.Y.) 1997 McCune JM -
Thymic function in HIV-1 disease.
Seminars in immunology 1997 McCune JM -
T cell turnover in HIV-1 disease.
Immunity 1997 Hellerstein MK, McCune JM -
Superantigen-mediated deletion of specific T cell receptor V beta subsets in the SCID-hu Thy/Liv mouse is induced by staphylococcal enterotoxin B, but not HIV-1.
Journal of immunology (Baltimore, Md. : 1950) 1997 Komanduri KV, Salha MD, Sékaly RP, McCune JM -
Identification of HIV-1 determinants for replication in vivo.
Virology 1997 Su L, Kaneshima H, Bonyhadi ML, Lee R, Auten J, Wolf A, Du B, Rabin L, Hahn BH, Terwilliger E, Mccune JM -
Development and applications of the SCID-hu mouse model.
Seminars in immunology 1996 McCune JM -
Measles virus infection of thymic epithelium in the SCID-hu mouse leads to thymocyte apoptosis.
Journal of virology 1996 Auwaerter PG, Kaneshima H, McCune JM, Wiegand G, Griffin DE -
Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry.
Antimicrobial agents and chemotherapy 1996 Datema R, Rabin L, Hincenbergs M, Moreno MB, Warren S, Linquist V, Rosenwirth B, Seifert J, McCune JM -
Use of standardized SCID-hu Thy/Liv mouse model for preclinical efficacy testing of anti-human immunodeficiency virus type 1 compounds.
Antimicrobial agents and chemotherapy 1996 Rabin L, Hincenbergs M, Moreno MB, Warren S, Linquist V, Datema R, Charpiot B, Seifert J, Kaneshima H, McCune JM -
HIV and the cells it infects: sorting the latent from the labile. An interview with Mike McCune, MD, PhD. Interview by Mark Mascolini.
Journal of the International Association of Physicians in AIDS Care 1996 McCune JM -
Development of a human thymic organ culture model for the study of HIV pathogenesis.
AIDS research and human retroviruses 1995 Bonyhadi ML, Su L, Auten J, McCune JM, Kaneshima H -
Viral latency in HIV disease.
Cell 1995 McCune JM -
HIV-1-induced thymocyte depletion is associated with indirect cytopathogenicity and infection of progenitor cells in vivo.
Immunity 1995 Su L, Kaneshima H, Bonyhadi M, Salimi S, Kraft D, Rabin L, McCune JM -
Rapid-high, syncytium-inducing isolates of human immunodeficiency virus type 1 induce cytopathicity in the human thymus of the SCID-hu mouse.
Journal of virology 1994 Kaneshima H, Su L, Bonyhadi ML, Connor RI, Ho DD, McCune JM -
Human hematolymphoid cells in SCID mice.
Current opinion in immunology 1994 Kaneshima H, Namikawa R, McCune JM -
Direct evaluation of radiation damage in human hematopoietic progenitor cells in vivo.
Radiation research 1994 Kyoizumi S, McCune JM, Namikawa R -
Human neural xenografts: progress in developing an in-vivo model to study human immunodeficiency virus (HIV) and human cytomegalovirus (HCMV) infection.
Advances in neuroimmunology 1994 Epstein LG, Cvetkovich TA, Lazar ES, DiLoreto D, Saito Y, James H, del Cerro C, Kaneshima H, McCune JM, Britt WJ -
Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse.
The Journal of experimental medicine 1993 Stanley SK, McCune JM, Kaneshima H, Justement JS, Sullivan M, Boone E, Baseler M, Adelsberger J, Bonyhadi M, Orenstein J -
HIV induces thymus depletion in vivo.
Nature 1993 Bonyhadi ML, Rabin L, Salimi S, Brown DA, Kosek J, McCune JM, Kaneshima H -
Human cytomegalovirus in a SCID-hu mouse: thymic epithelial cells are prominent targets of viral replication.
Proceedings of the National Academy of Sciences of the United States of America 1993 Mocarski ES, Bonyhadi M, Salimi S, McCune JM, Kaneshima H -
Implantation and maintenance of functional human bone marrow in SCID-hu mice.
Blood 1992 Kyoizumi S, Baum CM, Kaneshima H, McCune JM, Yee EJ, Namikawa R -
The SCID-hu mouse: a small animal model for the analysis of human hematolymphoid differentiation and function.
Bone marrow transplantation 1992 McCune JM -
Preclinical evaluation of human hematolymphoid function in the SCID-hu mouse.
Immunological reviews 1991 McCune JM, Péault B, Streeter PR, Rabin L -
Lymphoid reconstitution of the human fetal thymus in SCID mice with CD34+ precursor cells.
The Journal of experimental medicine 1991 Péault B, Weissman IL, Baum C, McCune JM, Tsukamoto A -
Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse.
Journal of immunology (Baltimore, Md. : 1950) 1991 Vandekerckhove BA, Krowka JF, McCune JM, de Vries JE, Spits H, Roncarolo MG -
Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent.
Journal of immunology (Baltimore, Md. : 1950) 1991 Krowka JF, Sarin S, Namikawa R, McCune JM, Kaneshima H -
Human immunodeficiency virus infection of human lymph nodes in the SCID-hu mouse.
Proceedings of the National Academy of Sciences of the United States of America 1991 Kaneshima H, Shih CC, Namikawa R, Rabin L, Outzen H, Machado SG, McCune JM -
SCID mice as immune system models.
Current opinion in immunology 1991 McCune JM -
Postexposure prophylaxis with zidovudine suppresses human immunodeficiency virus type 1 infection in SCID-hu mice in a time-dependent manner.
The Journal of infectious diseases 1991 Shih CC, Kaneshima H, Rabin L, Namikawa R, Sager P, McGowan J, McCune JM -
HIV-1: the infective process in vivo.
Cell 1991 McCune JM -
The SCID-hu mouse: a small animal model for HIV infection and pathogenesis.
Annual review of immunology 1991 McCune J, Kaneshima H, Krowka J, Namikawa R, Outzen H, Peault B, Rabin L, Shih CC, Yee E, Lieberman M -
Today's SCID-hu mouse.
Nature 1990 Kaneshima H, Baum C, Chen B, Namikawa R, Outzen H, Rabin L, Tsukamoto A, McCune JM -
Pseudotypes in HIV-infected mice.
Science (New York, N.Y.) 1990 McCune JM, Namikawa R, Shih CC, Rabin L, Kaneshima H -
Long-term human hematopoiesis in the SCID-hu mouse.
The Journal of experimental medicine 1990 Namikawa R, Weilbaecher KN, Kaneshima H, Yee EJ, McCune JM -
Suppression of HIV infection in AZT-treated SCID-hu mice.
Science (New York, N.Y.) 1990 McCune JM, Namikawa R, Shih CC, Rabin L, Kaneshima H -
Preclinical evaluation of antiviral compounds in the SCID-hu mouse.
Annals of the New York Academy of Sciences 1990 McCune JM, Kaneshima H, Rabin L, Shih CC, Namikawa R -
The scid-hu mouse: current status and potential applications.
Current topics in microbiology and immunology 1989 McCune JM, Kaneshima H, Lieberman M, Weissman IL, Namikawa R -
Infection of the SCID-hu mouse by HIV-1.
Science (New York, N.Y.) 1988 Namikawa R, Kaneshima H, Lieberman M, Weissman IL, McCune JM -
The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.
Science (New York, N.Y.) 1988 McCune JM, Namikawa R, Kaneshima H, Shultz LD, Lieberman M, Weissman IL -
Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus.
Cell 1988 McCune JM, Rabin LB, Feinberg MB, Lieberman M, Kosek JC, Reyes GR, Weissman IL -
Indirect induction of radiation lymphomas in mice. Evidence for a novel, transmissible leukemogen.
The Journal of experimental medicine 1987 Lieberman M, Hansteen GA, McCune JM, Scott ML, White JH, Weissman IL -
Ig biosynthesis in a human pre-B cell line.
Journal of immunology (Baltimore, Md. : 1950) 1981 McCune JM, Fu SM -
J chain biosynthesis in pre-B cells and other possible precursor B cells.
The Journal of experimental medicine 1981 McCune JM, Fu SM, Kunkel HG -
Biogenesis of membrane-bound and secreted immunoglobulins. II. Two forms of the human alpha chain translated in vitro and processed in vivo as distinct polypeptide chains.
The Journal of experimental medicine 1981 McCune JM, Fu SM, Blobel G, Kunkel HG -
Pre-B cells and other possible precursor lymphoid cell lines derived from patients with X-linked agammaglobulinemia.
The Journal of experimental medicine 1980 Fu SM, Hurley JN, McCune JM, Kunkel HG, Good RA -
Biogenesis of membrane-bound and secreted immunoglobulins. I. Two distinct translation products of human mu-chain, with identical N-termini and different C-termini.
The Journal of experimental medicine 1980 McCune JM, Lingappa VR, Fu SM, Blobel G, Kunkel HG -
Two types of Ia-positive T cells. Synthesis and exchange of Ia antigens.
The Journal of experimental medicine 1980 Yu DT, McCune JM, Fu SM, Winchester RJ, Kunkel HG -
Isolation and immunologic characterization of a human. B-lymphocyte-specific, cell surface antigen.
The Journal of experimental medicine 1976 Humphreys RE, McCune JM, Chess L, Herrman HC, Malenka DJ, Mann DL, Parham P, Schlossman SF, Strominger JL -
The immunoglobulin-like structure of human histocompatibility antigens.
Federation proceedings 1976 Strominger JL, Humphreys RE, McCune JM, Parham P, Robb R, Springer T, Terhorst C -
Enhanced representation of HL-A antigens on human lymphocytes after mitogenesis induced by phytohemagglutinin or Epstein-Barr virus.
Proceedings of the National Academy of Sciences of the United States of America 1975 McCune JM, Humphreys RE, Yocum RR, Strominger JL