Midori Yenari, MD
Professor
Neurology
School of Medicine

Grants and Projects

Show all (5) Hide

• Inflammatory mechanisms in cerebral ischemia, NIH, 2019-2024
• Calcium release-activated calcium (CRAC) channel inhibitors in experimental stroke, NIH, 2017-2020
• Heat shock proteins in brain ischemia and stroke, NIH, 2011-2019
• Inflammatory mechanisms in cerebral ischemia, NIH, 2000-2016
• Mild Hypothermia in Focal Cerebral Ischemia, NIH, 1995-2001

Publications (165)

Top publication keywords:
Brain IschemiaDynaminsBrainHypothermia, InducedStrokeInfarction, Middle Cerebral ArteryPhagocytosisSkin TemperatureIschemic Attack, TransientMicrogliaNADPH OxidasesHSP70 Heat-Shock ProteinsNeuroprotectionBrain InjuriesNeuroprotective Agents

• In cold blood: a new way to achieve therapeutic cooling?
  Science bulletin 2023 Yenari MA
• Most Promising Approaches to Improve Stroke Outcomes: The Stroke Treatment Academic Industry Roundtable XII Workshop.
  Stroke 2023 Wechsler LR, Adeoye O, Alemseged F, Bahr-Hosseini M, Deljkich E, Favilla C, Fisher M, Grotta J, Hill MD, Kamel H, Khatri P, Lyden P, Mirza M, Nguyen TN, Samaniego E, Schwamm L, Selim M, Silva G, …
• Use of Botulinum Toxin for Limb Immobilization for Rehabilitation in Rats with Experimental Stroke.
  Biomolecules 2023 Zhang H, Liu J, Bingham D, Orr A, Kawabori M, Kim JY, Zheng Z, Lam TI, Massa SM, Swanson RA, Yenari MA
• Collateral Flow: Prolonging the Ischemic Penumbra.
  Translational stroke research 2023 Dhar R, Yu W, Yenari M, Lee JM
• Therapeutic hypothermia for stroke: Unique challenges at the bedside.
  Frontiers in neurology 2022 You JS, Kim JY, Yenari MA

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• Sexual dimorphism in immune cell responses following stroke.
  Neurobiology of disease 2022 Liu J, Sato Y, Falcone-Juengert J, Kurisu K, Shi J, Yenari MA
• Cerebral small vessel disease alters neurovascular unit regulation of microcirculation integrity involved in vascular cognitive impairment.
  Neurobiology of disease 2022 Yang Q, Wei X, Deng B, Chang Z, Jin D, Huang Y, Zhang JH, Yenari MA, Jin K, Wang Q
• Multimodal analysis of gene expression from postmortem brains and blood identifies synaptic vesicle trafficking genes to be associated with Parkinson's disease.
  Briefings in bioinformatics 2021 Gao X, Huang Z, Feng C, Guan C, Li R, Xie H, Chen J, Li M, Que R, Deng B, Cao P, Li M, Lu J, Huang Y, Li M, Yang W, Yang X, Wen C, Liang X, Yang Q, Chao YX, Chan LL, Yenari MA, Jin K, Chaudhuri KR, …
• Fibrinogen is an Independent Risk Factor for White Matter Hyperintensities in CADASIL but not in Sporadic Cerebral Small Vessel Disease Patients.
  Aging and disease 2021 Guo X, Deng B, Zhong L, Xie F, Qiu Q, Wei X, Wang W, Xu J, Liu G, Hon WPT, Yenari MA, Zhu S, Wang Q
• Clinical perspectives on ischemic stroke.
  Experimental neurology 2021 Mizuma A, Yenari MA
• Cystatin C is a potential predictor of unfavorable outcomes for cerebral ischemia with intravenous tissue plasminogen activator treatment: A multicenter prospective nested case-control study.
  European journal of neurology 2020 Chang Z, Zou H, Xie Z, Deng B, Que R, Huang Z, Weng G, Wu Z, Pan Y, Wang Y, Li M, Xie H, Zhu S, Xiong L, Ct Mok V, Jin K, Yenari MA, Wei X, Wang Q
• Microglia, the brain's double agent.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2020 Yenari MA
• Heat Shock Protein 70 (HSP70) Induction: Chaperonotherapy for Neuroprotection after Brain Injury.
  Cells 2020 Kim JY, Barua S, Huang MY, Park J, Yenari MA, Lee JE
• Vascular, inflammatory and metabolic risk factors in relation to dementia in Parkinson's disease patients with type 2 diabetes mellitus.
  Aging 2020 Wang T, Yuan F, Chen Z, Zhu S, Chang Z, Yang W, Deng B, Que R, Cao P, Chao Y, Chan L, Pan Y, Wang Y, Xu L, Lyu Q, Chan P, Yenari MA, Tan EK, Wang Q
• Cofilin-actin rod formation in experimental stroke is attenuated by therapeutic hypothermia and overexpression of the inducible 70 kD inducible heat shock protein (Hsp70).
  Brain circulation 2019 Kurisu K, You J, Zheng Z, Won SJ, Swanson RA, Yenari MA
• Heat shock protein signaling in brain ischemia and injury.
  Neuroscience letters 2019 Kim JY, Kim JW, Yenari MA
• Models of poststroke depression and assessments of core depressive symptoms in rodents: How to choose?
  Experimental neurology 2019 Tao X, Yang W, Zhu S, Que R, Liu C, Fan T, Wang J, Mo D, Zhang Z, Tan J, Jin K, Yenari MA, Song T, Wang Q
• Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment.
  Aging and disease 2019 Zhu S, Wei X, Yang X, Huang Z, Chang Z, Xie F, Yang Q, Ding C, Xiang W, Yang H, Xia Y, Feng ZP, Sun HS, Yenari MA, Shi L, Mok VC, Wang Q
• The role of NOX inhibitors in neurodegenerative diseases.
  IBRO reports 2019 Barua S, Kim JY, Yenari MA, Lee JE
• Therapeutic Hypothermia and Neuroprotection in Acute Neurological Disease.
  Current medicinal chemistry 2019 Kurisu K, Kim JY, You J, Yenari MA
• Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2018 Kurisu K, Zheng Z, Kim JY, Shi J, Kanoke A, Liu J, Hsieh CL, Yenari MA
• Microglial Calcium Release-Activated Calcium Channel Inhibition Improves Outcome from Experimental Traumatic Brain Injury and Microglia-Induced Neuronal Death.
  Journal of neurotrauma 2018 Mizuma A, Kim JY, Kacimi R, Stauderman K, Dunn M, Hebbar S, Yenari MA
• Targeting Reperfusion Injury in the Age of Mechanical Thrombectomy.
  Stroke 2018 Mizuma A, You JS, Yenari MA
• Advances in Stroke 2017.
  Stroke 2018 Bernhardt J, Zorowitz RD, Becker KJ, Keller E, Saposnik G, Strbian D, Dichgans M, Woo D, Reeves M, Thrift A, Kidwell CS, Olivot JM, Goyal M, Pierot L, Bennett DA, Howard G, Ford GA, Goldstein LB, …
• The 70-kDa heat shock protein (Hsp70) as a therapeutic target for stroke.
  Expert opinion on therapeutic targets 2018 Kim JY, Han Y, Lee JE, Yenari MA
• Reconsidering Neuroprotection in the Reperfusion Era.
  Stroke 2017 Savitz SI, Baron JC, Yenari MA, Sanossian N, Fisher M
• Anti-Inflammatory Targets for the Treatment of Reperfusion Injury in Stroke.
  Frontiers in neurology 2017 Mizuma A, Yenari MA
• NOX Inhibitors - A Promising Avenue for Ischemic Stroke.
  Experimental neurobiology 2017 Kim JY, Park J, Lee JE, Yenari MA
• Therapeutic hypothermia for ischemic stroke; pathophysiology and future promise.
  Neuropharmacology 2017 Kurisu K, Yenari MA
• Hypothermia Identifies Dynamin as a Potential Therapeutic Target in Experimental Stroke.
  Therapeutic hypothermia and temperature management 2017 Kim JY, Kim N, Lee JE, Yenari MA
• Activated complement protein C5a does not affect brain-derived endothelial cell viability and zonula occludens-1 levels following oxygen-glucose deprivation.
  Brain circulation 2017 Khoyetsyan A, Kacimi R, Tsakanova G, Boyajyan A, Arakelyan A, Yenari MA
• 70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke: A New Therapeutic Target?
  Stroke 2016 Kim JY, Kim N, Zheng Z, Lee JE, Yenari MA
• Postinjury Neuroplasticity in Central Neural Networks.
  Neural plasticity 2015 Lee BH, Lim TH, Yoon YW, Yenari MA, Jeong Y
• Pharmacologic heat shock protein 70 induction confers cytoprotection against inflammation in gliovascular cells.
  Glia 2015 Kacimi R, Yenari MA
• Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Kawabori M, Kacimi R, Kauppinen T, Calosing C, Kim JY, Hsieh CL, Nakamura MC, Yenari MA
• Inflammatory responses in brain ischemia.
  Current medicinal chemistry 2015 Kawabori M, Yenari MA
• Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen-glucose deprivation.
  Neuroscience 2014 Kim JY, Yenari MA, Lee JE
• Mechanisms and potential therapeutic applications of microglial activation after brain injury.
  CNS neuroscience & therapeutics 2014 Kim JY, Kim N, Yenari MA
• Pharmacological induction of the 70-kDa heat shock protein protects against brain injury.
  Neuroscience 2014 Kim N, Kim JY, Yenari MA
• Calcium-sensing receptor (CaSR) as a novel target for ischemic neuroprotection.
  Annals of clinical and translational neurology 2014 Kim JY, Ho H, Kim N, Liu J, Tu CL, Yenari MA, Chang W
• The role of the microglia in acute CNS injury.
  Metabolic brain disease 2014 Kawabori M, Yenari MA
• Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets.
  Current medicinal chemistry 2014 Kim JY, Kawabori M, Yenari MA
• Triggering Receptor Expressed on Myeloid Cells-2 Correlates to Hypothermic Neuroprotection in Ischemic Stroke.
  Therapeutic hypothermia and temperature management 2013 Kawabori M, Hokari M, Zheng Z, Kim JY, Calosing C, Hsieh CL, Nakamura MC, Yenari MA
• Microglial P2Y12 deficiency/inhibition protects against brain ischemia.
  PloS one 2013 Webster CM, Hokari M, McManus A, Tang XN, Ma H, Kacimi R, Yenari MA
• Influence of therapeutic hypothermia on regeneration after cerebral ischemia.
  Frontiers of neurology and neuroscience 2013 Yenari MA, Han HS
• Hypothermia and pharmacological regimens that prevent overexpression and overactivity of the extracellular calcium-sensing receptor protect neurons against traumatic brain injury.
  Journal of neurotrauma 2013 Kim JY, Kim N, Yenari MA, Chang W
• The 70 kDa heat shock protein protects against experimental traumatic brain injury.
  Neurobiology of disease 2013 Kim JY, Kim N, Zheng Z, Lee JE, Yenari MA
• Mild hypothermia reduces tissue plasminogen activator-related hemorrhage and blood brain barrier disruption after experimental stroke.
  Therapeutic hypothermia and temperature management 2013 Tang XN, Liu L, Koike MA, Yenari MA
• Sphingolipids in cardiovascular and cerebrovascular systems: Pathological implications and potential therapeutic targets.
  World journal of cardiology 2013 Kawabori M, Kacimi R, Karliner JS, Yenari MA
• The immune modulating properties of the heat shock proteins after brain injury.
  Anatomy & cell biology 2013 Kim JY, Yenari MA
• Neuroprotection after cerebral ischemia.
  Annals of the New York Academy of Sciences 2013 Namura S, Ooboshi H, Liu J, Yenari MA
• The multifaceted effects of agmatine on functional recovery after spinal cord injury through Modulations of BMP-2/4/7 expressions in neurons and glial cells.
  PloS one 2013 Park YM, Lee WT, Bokara KK, Seo SK, Park SH, Kim JH, Yenari MA, Park KA, Lee JE
• Temperature affects thrombolytic efficacy using rt-Pa and eptifibatide, an in vitro study: editorial commentary on Meunier et al., 2012.
  Therapeutic hypothermia and temperature management 2012 Yenari MA
• Bone marrow chimeras in the study of experimental stroke.
  Translational stroke research 2012 Tang XN, Zheng Z, Yenari MA
• NADPH oxidase in stroke and cerebrovascular disease.
  Neurological research 2012 Tang XN, Cairns B, Kim JY, Yenari MA
• Neuroprotective mechanisms of hypothermia in brain ischaemia.
  Nature reviews. Neuroscience 2012 Yenari MA, Han HS
• NOX inhibitors as a therapeutic strategy for stroke and neurodegenerative disease.
  Current drug targets 2012 Cairns B, Kim JY, Tang XN, Yenari MA
• Therapeutic hypothermia in stroke.
  Stroke research and treatment 2012 Yenari MA, Colbourne F, Hemmen TM, Han HS, Krieger D
• Anti-inflammatory properties and pharmacological induction of Hsp70 after brain injury.
  Inflammopharmacology 2012 Kim N, Kim JY, Yenari MA
• Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by Increasing superoxide production.
  Annals of neurology 2011 Won SJ, Tang XN, Suh SW, Yenari MA, Swanson RA
• Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke.
  Annals of neurology 2011 Tang XN, Zheng Z, Giffard RG, Yenari MA
• Brain 11: what's new in stroke research?
  Expert review of neurotherapeutics 2011 Yenari MA, Lee JE
• Therapeutic hypothermia after cardiac arrest: experience at an academically affiliated community-based veterans affairs medical center.
  Stroke research and treatment 2011 Shah MP, Zimmerman L, Bullard J, Yenari MA
• Simvastatin prevents dopaminergic neurodegeneration in experimental parkinsonian models: the association with anti-inflammatory responses.
  PloS one 2011 Yan J, Xu Y, Zhu C, Zhang L, Wu A, Yang Y, Xiong Z, Deng C, Huang XF, Yenari MA, Yang YG, Ying W, Wang Q
• Mild Hypothermia Suppresses Calcium-Sensing Receptor (CaSR) Induction Following Forebrain Ischemia While Increasing GABA-B Receptor 1 (GABA-B-R1) Expression.
  Translational stroke research 2011 Kim JY, Kim N, Yenari MA, Chang W
• Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways.
  Journal of inflammation (London, England) 2011 Kacimi R, Giffard RG, Yenari MA
• Direct protection of cultured neurons from ischemia-like injury by minocycline.
  Anatomy & cell biology 2010 Huang WC, Qiao Y, Xu L, Kacimi R, Sun X, Giffard RG, Yenari MA
• Microglial activation in stroke: therapeutic targets.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2010 Yenari MA, Kauppinen TM, Swanson RA
• Therapeutic hypothermia for brain ischemia: where have we come and where do we go?
  Stroke 2010 Yenari MA, Hemmen TM
• Endogenous agmatine inhibits cerebral vascular matrix metalloproteinases expression by regulating activating transcription factor 3 and endothelial nitric oxide synthesis.
  Current neurovascular research 2010 Jung HJ, Yang MZ, Kwon KH, Yenari MA, Choi YJ, Lee WT, Park KA, Lee JE
• Migraine and vertebrobasilar dissection: Case reports.
  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2010 Yenari MA, Steinberg GK, Marks MP
• Digitally quantifying cerebral hemorrhage using Photoshop and Image J.
  Journal of neuroscience methods 2010 Tang XN, Berman AE, Swanson RA, Yenari MA
• Statins: multiple neuroprotective mechanisms in neurodegenerative diseases.
  Experimental neurology 2010 Wang Q, Yan J, Chen X, Li J, Yang Y, Weng J, Deng C, Yenari MA
• Alterations in 5-HT2A receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats.
  Synapse (New York, N.Y.) 2010 Li Y, Huang XF, Deng C, Meyer B, Wu A, Yu Y, Ying W, Yang GY, Yenari MA, Wang Q
• Hypothermia as a cytoprotective strategy in ischemic tissue injury.
  Ageing research reviews 2009 Tang XN, Yenari MA
• Does inflammation after stroke affect the developing brain differently than adult brain?
  Developmental neuroscience 2009 Vexler ZS, Yenari MA
• Pyruvate protects against experimental stroke via an anti-inflammatory mechanism.
  Neurobiology of disease 2009 Wang Q, van Hoecke M, Tang XN, Lee H, Zheng Z, Swanson RA, Yenari MA
• Clinical application of therapeutic hypothermia in stroke.
  Neurological research 2009 Liu L, Yenari MA
• A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia.
  Journal of neurochemistry 2009 Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE
• Combination therapy with hypothermia for treatment of cerebral ischemia.
  Journal of neurotrauma 2009 Tang XN, Liu L, Yenari MA
• Glucose and NADPH oxidase drive neuronal superoxide formation in stroke.
  Annals of neurology 2008 Suh SW, Shin BS, Ma H, Van Hoecke M, Brennan AM, Yenari MA, Swanson RA
• Inflammation and NFkappaB activation is decreased by hypothermia following global cerebral ischemia.
  Neurobiology of disease 2008 Webster CM, Kelly S, Koike MA, Chock VY, Giffard RG, Yenari MA
• Metabolic downregulation: a key to successful neuroprotection?
  Stroke 2008 Yenari M, Kitagawa K, Lyden P, Perez-Pinzon M
• epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury.
  Neuroscience letters 2008 Bright R, Sun GH, Yenari MA, Steinberg GK, Mochly-Rosen D
• Apocynin improves outcome in experimental stroke with a narrow dose range.
  Neuroscience 2008 Tang XN, Cairns B, Cairns N, Yenari MA
• Chronic treatment with simvastatin upregulates muscarinic M1/4 receptor binding in the rat brain.
  Neuroscience 2008 Wang Q, Zengin A, Ying W, Newell KA, Wang P, Yeo W, Wong PT, Yenari MA, Huang XF
• FasL shedding is reduced by hypothermia in experimental stroke.
  Journal of neurochemistry 2008 Liu L, Kim JY, Koike MA, Yoon YJ, Tang XN, Ma H, Lee H, Steinberg GK, Lee JE, Yenari MA
• Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemia.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2007 Tang XN, Wang Q, Koike MA, Cheng D, Goris ML, Blankenberg FG, Yenari MA
• Conditions of protection by hypothermia and effects on apoptotic pathways in a rat model of permanent middle cerebral artery occlusion.
  Journal of neurosurgery 2007 Zhao H, Wang JQ, Shimohata T, Sun G, Yenari MA, Sapolsky RM, Steinberg GK
• Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007 Zheng Z, Kim JY, Ma H, Lee JE, Yenari MA
• Subclinical embolization after carotid artery stenting: new lesions on diffusion-weighted magnetic resonance imaging occur postprocedure.
  Journal of vascular surgery 2007 Rapp JH, Wakil L, Sawhney R, Pan XM, Yenari MA, Glastonbury C, Coogan S, Wintermark M
• Therapeutic hypothermia: neuroprotective mechanisms.
  Frontiers in bioscience : a journal and virtual library 2007 Liu L, Yenari MA
• The inflammatory response in stroke.
  Journal of neuroimmunology 2006 Wang Q, Tang XN, Yenari MA
• INTRODUCTION: Immune mechanisms of neurodegeneration.
  Clinical neuroscience research 2006 Yenari MA, Swanson RA
• Inflammation in adult and neonatal stroke.
  Clinical neuroscience research 2006 Vexler ZS, Tang XN, Yenari MA
• Effects of high dose of simvastatin on levels of dopamine and its reuptake in prefrontal cortex and striatum among SD rats.
  Neuroscience letters 2006 Wang Q, Tang XN, Wang L, Yenari MA, Ying W, Goh BC, Lee HS, Wilder-Smith EP, Wong PT
• Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NFkappaB).
  Neurochemistry international 2006 Yenari MA, Han HS
• Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro.
  Stroke 2006 Yenari MA, Xu L, Tang XN, Qiao Y, Giffard RG
• 99mTc-HYNIC-annexin V SPECT imaging of acute stroke and its response to neuroprotective therapy with anti-Fas ligand antibody.
  European journal of nuclear medicine and molecular imaging 2006 Blankenberg FG, Kalinyak J, Liu L, Koike M, Cheng D, Goris ML, Green A, Vanderheyden JL, Tong DC, Yenari MA
• Therapeutic hypothermia for acute stroke.
  International journal of stroke : official journal of the International Stroke Society 2006 Lyden PD, Krieger D, Yenari M, Dietrich WD
• The application of HSP70 as a target for gene therapy.
  Frontiers in bioscience : a journal and virtual library 2006 Zheng Z, Yenari MA
• Biphasic cytochrome c release after transient global ischemia and its inhibition by hypothermia.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005 Zhao H, Yenari MA, Cheng D, Sapolsky RM, Steinberg GK
• Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection.
  Annals of the New York Academy of Sciences 2005 Yenari MA, Liu J, Zheng Z, Vexler ZS, Lee JE, Giffard RG
• Reduction in levels of matrix metalloproteinases and increased expression of tissue inhibitor of metalloproteinase-2 in response to mild hypothermia therapy in experimental stroke.
  Journal of neurosurgery 2005 Lee JE, Yoon YJ, Moseley ME, Yenari MA
• Gene therapy in neurological disease.
  Methods in molecular medicine 2005 Yenari MA, Sapolsky RM
• Mild hypothermia decreases GSK3beta expression following global cerebral ischemia.
  Neurocritical care 2005 Kelly S, Cheng D, Steinberg GK, Yenari MA
• Post-ischemic inflammation: molecular mechanisms and therapeutic implications.
  Neurological research 2004 Zheng Z, Yenari MA
• Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury.
  Experimental neurology 2004 Kim JH, Yenari MA, Giffard RG, Cho SW, Park KA, Lee JE
• Protein kinase C delta mediates cerebral reperfusion injury in vivo.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Bright R, Raval AP, Dembner JM, Pérez-Pinzón MA, Steinberg GK, Yenari MA, Mochly-Rosen D
• Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury.
  The Journal of experimental biology 2004 Giffard RG, Xu L, Zhao H, Carrico W, Ouyang Y, Qiao Y, Sapolsky R, Steinberg G, Hu B, Yenari MA
• Glycogen synthase kinase 3beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia.
  Experimental neurology 2004 Kelly S, Zhao H, Hua Sun G, Cheng D, Qiao Y, Luo J, Martin K, Steinberg GK, Harrison SD, Yenari MA
• Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Kelly S, Bliss TM, Shah AK, Sun GH, Ma M, Foo WC, Masel J, Yenari MA, Weissman IL, Uchida N, Palmer T, Steinberg GK
• Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2004 Zhao H, Yenari MA, Cheng D, Barreto-Chang OL, Sapolsky RM, Steinberg GK
• Therapeutic hypothermia for acute ischemic stroke: what do laboratory studies teach us?
  Stroke 2004 Krieger DW, Yenari MA
• Catalase over-expression protects striatal neurons from transient focal cerebral ischemia.
  Neuroreport 2004 Gu W, Zhao H, Yenari MA, Sapolsky RM, Steinberg GK
• The 70 kDa heat shock protein suppresses matrix metalloproteinases in astrocytes.
  Neuroreport 2004 Lee JE, Kim YJ, Kim JY, Lee WT, Yenari MA, Giffard RG
• Detection of focal hypoxic-ischemic injury and neuronal stress in a rodent model of unilateral MCA occlusion/reperfusion using radiolabeled annexin V.
  European journal of nuclear medicine and molecular imaging 2004 Mari C, Karabiyikoglu M, Goris ML, Tait JF, Yenari MA, Blankenberg FG
• Mild postischemic hypothermia prolongs the time window for gene therapy by inhibiting cytochrome C release.
  Stroke 2004 Zhao H, Yenari MA, Sapolsky RM, Steinberg GK
• Many mechanisms for hsp70 protection from cerebral ischemia.
  Journal of neurosurgical anesthesiology 2004 Giffard RG, Yenari MA
• Pathophysiology of acute ischemic stroke.
  Cleveland Clinic journal of medicine 2004 Yenari MA
• Cellular and molecular events underlying ischemia-induced neuronal apoptosis.
  Drug news & perspectives 2003 Zheng Z, Zhao H, Steinberg GK, Yenari MA
• Glutathione peroxidase overexpression inhibits cytochrome C release and proapoptotic mediators to protect neurons from experimental stroke.
  Stroke 2003 Hoehn B, Yenari MA, Sapolsky RM, Steinberg GK
• Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation.
  Stroke 2003 Deng H, Han HS, Cheng D, Sun GH, Yenari MA
• Attenuation of nitric oxide synthase isoform expression by mild hypothermia after focal cerebral ischemia: variations depending on timing of cooling.
  Journal of neurosurgery 2003 Karabiyikoglu M, Han HS, Yenari MA, Steinberg GK
• Stroke: molecular mechanisms and potential targets for treatment.
  Current molecular medicine 2003 Zheng Z, Lee JE, Yenari MA
• Bcl-2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase-3 activity.
  Journal of neurochemistry 2003 Zhao H, Yenari MA, Cheng D, Sapolsky RM, Steinberg GK
• Cellular targets of brain inflammation in stroke.
  Current opinion in investigational drugs (London, England : 2000) 2003 Han HS, Yenari MA
• Gene therapy and hypothermia for stroke treatment.
  Annals of the New York Academy of Sciences 2003 Yenari MA, Zhao H, Giffard RG, Sobel RA, Sapolsky RM, Steinberg GK
• Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003 Han HS, Karabiyikoglu M, Kelly S, Sobel RA, Yenari MA
• Prospects for the treatment of stroke using gene therapy.
  Expert review of neurotherapeutics 2003 Zhao H, Yenari MA, Sapolsky RM, Steinberg GK
• Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2.
  Annals of neurology 2002 Kelly S, Zhang ZJ, Zhao H, Xu L, Giffard RG, Sapolsky RM, Yenari MA, Steinberg GK
• Use of diffusion weighted MRI to predict the occurrence and severity of hemorrhagic transformation in a rabbit model of embolic stroke.
  Brain research 2002 Adami A, Thijs V, Tong DC, Beaulieu C, Moseley ME, Yenari MA
• Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Han HS, Qiao Y, Karabiyikoglu M, Giffard RG, Yenari MA
• Heat shock proteins and neuroprotection.
  Advances in experimental medicine and biology 2002 Yenari MA
• Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002 Yenari MA, Iwayama S, Cheng D, Sun GH, Fujimura M, Morita-Fujimura Y, Chan PH, Steinberg GK
• Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002 Xu L, Yenari MA, Steinberg GK, Giffard RG
• Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001 Hoehn B, Ringer TM, Xu L, Giffard RG, Sapolsky RM, Steinberg GK, Yenari MA
• Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions.
  Experimental neurology 2001 Lee JE, Yenari MA, Sun GH, Xu L, Emond MR, Cheng D, Steinberg GK, Giffard RG
• Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors.
  Annals of the New York Academy of Sciences 2001 Yenari MA, Dumas TC, Sapolsky RM, Steinberg GK
• Calbindin d28k overexpression protects striatal neurons from transient focal cerebral ischemia.
  Stroke 2001 Yenari MA, Minami M, Sun GH, Meier TJ, Kunis DM, McLaughlin JR, Ho DY, Sapolsky RM, Steinberg GK
• Gene therapy effectiveness differs for neuronal survival and behavioral performance.
  Gene therapy 2001 Phillips RG, Monje ML, Giuli LC, Meier TJ, Yenari MA, Kunis D, Sapolsky RM
• Ischemic vulnerability of primary murine microglial cultures.
  Neuroscience letters 2001 Yenari MA, Giffard RG
• Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct size.
  Journal of neurosurgery 2001 Maier CM, Sun GH, Kunis D, Yenari MA, Steinberg GK
• Diffusion- and perfusion-weighted magnetic resonance imaging of focal cerebral ischemia and cortical spreading depression under conditions of mild hypothermia.
  Brain research 2000 Yenari MA, Onley D, Hedehus M, deCrespigny A, Sun GH, Moseley ME, Steinberg GK
• 99mTc annexin V imaging of neonatal hypoxic brain injury.
  Stroke 2000 D'Arceuil H, Rhine W, de Crespigny A, Yenari M, Tait JF, Strauss WH, Engelhorn T, Kastrup A, Moseley M, Blankenberg FG
• Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation.
  Stroke 2000 Neumann-Haefelin T, Kastrup A, de Crespigny A, Yenari MA, Ringer T, Sun GH, Moseley ME
• The neuroprotective potential of heat shock protein 70 (HSP70).
  Molecular medicine today 1999 Yenari MA, Giffard RG, Sapolsky RM, Steinberg GK
• A standardized MRI stroke protocol: comparison with CT in hyperacute intracerebral hemorrhage.
  Stroke 1999 Tong DC, Albers GW, Yenari MA, Marks MP
• Intra-arterial rtPA treatment of stroke assessed by diffusion- and perfusion-weighted MRI.
  Stroke 1999 Lansberg MG, Tong DC, Norbash AM, Yenari MA, Moseley ME
• Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy.
  Annals of neurology 1998 Yenari MA, Fink SL, Sun GH, Chang LK, Patel MK, Kunis DM, Onley D, Ho DY, Sapolsky RM, Steinberg GK
• Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia.
  Experimental neurology 1998 Yenari MA, Kunis D, Sun GH, Onley D, Watson L, Turner S, Whitaker S, Steinberg GK
• Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia: effects on neurologic outcome, infarct size, apoptosis, and inflammation.
  Stroke 1998 Maier CM, Ahern Kv, Cheng ML, Lee JE, Yenari MA, Steinberg GK
• Thrombolysis with reteplase, an unglycosylated plasminogen activator variant, in experimental embolic stroke.
  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 1998 Yenari MA, Lee LK, Beaulieu C, Sun GH, Kunis D, Chang D, Albers GW, Moseley ME, Steinberg GK
• Correlation of perfusion- and diffusion-weighted MRI with NIHSS score in acute (<6.5 hour) ischemic stroke.
  Neurology 1998 Tong DC, Yenari MA, Albers GW, O'Brien M, Marks MP, Moseley ME
• Editorial commentary.
  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 1998 Adams HP, Yenari M, McDowell FH, Yonas H
• Dose escalation safety and tolerance study of the competitive NMDA antagonist selfotel (CGS 19755) in neurosurgery patients.
  Clinical neuropharmacology 1998 Yenari MA, Bell TE, Kotake AN, Powell M, Steinberg GK
• SNX-111, a novel, presynaptic N-type calcium channel antagonist, is neuroprotective against focal cerebral ischemia in rabbits.
  Journal of the neurological sciences 1997 Perez-Pinzon MA, Yenari MA, Sun GH, Kunis DM, Steinberg GK
• Diffusion-weighted magnetic resonance imaging characteristics of hemorrhagic transformation in experimental embolic stroke.
  Journal of neuroimaging : official journal of the American Society of Neuroimaging 1997 Yenari MA, Beaulieu C, Steinberg GK, Moseley ME
• Improved perfusion with rt-PA and hirulog in a rabbit model of embolic stroke.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997 Yenari MA, de Crespigny A, Palmer JT, Roberts S, Schrier SL, Albers GW, Moseley ME, Steinberg GK
• Intravenous thrombolytic therapy in acute stroke.
  Vascular medicine (London, England) 1997 Tong DC, Yenari MA, Albers GW
• Time-course and treatment response with SNX-111, an N-type calcium channel blocker, in a rodent model of focal cerebral ischemia using diffusion-weighted MRI.
  Brain research 1996 Yenari MA, Palmer JT, Sun GH, de Crespigny A, Mosely ME, Steinberg GK
• Dose escalation safety and tolerance study of the N-methyl-D-aspartate antagonist dextromethorphan in neurosurgery patients.
  Journal of neurosurgery 1996 Steinberg GK, Bell TE, Yenari MA
• Safety of heparin in acute ischemic stroke.
  Neurology 1996 Hart RG, Boop BS, Tong DC, Yenari MA, Albers GW
• Clinical aspects of DWI.
  NMR in biomedicine 1995 Moseley ME, Butts K, Yenari MA, Marks M, de Crespigny A
• Thrombolysis with tissue plasminogen activator (tPA) is temperature dependent.
  Thrombosis research 1995 Yenari MA, Palmer JT, Bracci PM, Steinberg GK