Michelle Moritz, PhD
Research Biochemist
Biochemistry and Biophysics
School of Medicine

Websites

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• Profile at msg.ucsf.edu (msg.ucsf.edu)

Publications (13)

Top publication keywords:
Protein BindingProtein Structure, QuaternaryCell NucleusMitochondrial Membrane Transport ProteinsSaccharomyces cerevisiae ProteinsTubulinViral Nonstructural ProteinsMicrotubulesCatalytic DomainProtein Interaction MapsMicrotubule-Associated ProteinsSevere Acute Respiratory SyndromeCasein Kinase IdeltaNerve DegenerationMicrotubule-Organizing Center

• Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
  Cell 2022 Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Hüttenhain R, Kauwe G, Mercedes M, Sweetland-Martin L, Chen X, Mok SA, Wong MY, Telpoukhovskaia M, Min SW, Wang…
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  Research square 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  bioRxiv : the preprint server for biology 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• Microtubules form by progressively faster tubulin accretion, not by nucleation-elongation.
  The Journal of cell biology 2021 Rice LM, Moritz M, Agard DA
• Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.
  Science advances 2021 Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Carvalho Martins L, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N,…

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• Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking.
  bioRxiv : the preprint server for biology 2020 Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Martins LC, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N, …
• Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
  Science (New York, N.Y.) 2020 Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor…
• XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions.
  Molecular biology of the cell 2020 King BR, Moritz M, Kim H, Agard DA, Asbury CL, Davis TN
• Higher-order oligomerization of Spc110p drives γ-tubulin ring complex assembly.
  Molecular biology of the cell 2016 Lyon AS, Morin G, Moritz M, Yabut KC, Vojnar T, Zelter A, Muller E, Davis TN, Agard DA
• Interaction of CK1δ with γTuSC ensures proper microtubule assembly and spindle positioning.
  Molecular biology of the cell 2015 Peng Y, Moritz M, Han X, Giddings TH, Lyon A, Kollman J, Winey M, Yates J, Agard DA, Drubin DG, Barnes G
• Ring closure activates yeast γTuRC for species-specific microtubule nucleation.
  Nature structural & molecular biology 2015 Kollman JM, Greenberg CH, Li S, Moritz M, Zelter A, Fong KK, Fernandez JJ, Sali A, Kilmartin J, Davis TN, Agard DA
• Gamma-tubulin complexes and microtubule nucleation.
  Current opinion in structural biology 2001 Moritz M, Agard DA
• Structure of the gamma-tubulin ring complex: a template for microtubule nucleation.
  Nature cell biology 2000 Moritz M, Braunfeld MB, Guénebaut V, Heuser J, Agard DA