Michelle Yu, MD, PhD
Assistant Professor
Medicine
School of Medicine

I am a Pulmonary and Critical Care Physician-Scientist. My clinical and research specialties are in Cystic Fibrosis lung infection and inflammation. I am the Principal Investigator of a basic science laboratory, and I serve as the Associate Program director of the UCSF Adult Cystic Fibrosis Center. I attend regularly in the ICUs at Parnassus and Mount Zion and am passionate about improving medical education particularly during COVID when our learners have faced unforeseen challenges.

Education & Training

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• Pulmonary and Critical Care Fellowship UCSF 07/2018
• Internal Medicine Residency Brigham and Women's Hospital 07/2014
• MD, PhD Biophysics and Physiology Albert Einstein College of Medicine 06/2011
• B.A. Chemistry and Physics Harvard University 06/2003

Publications (11)

Top publication keywords:
TyrosinePseudomonas aeruginosaFetusPeroxidesOxygenPseudomonas InfectionsDehydroascorbic AcidHydrogen PeroxideSulfur DioxideCRISPR-Cas SystemsFree RadicalsCystic FibrosisElectron Spin Resonance SpectroscopyElectron Transport Complex IVPneumonia, Bacterial

• Investigating Pseudomonas aeruginosa Gene Function During Pathogenesis Using Mobile-CRISPRi.
  Methods in molecular biology (Clifton, N.J.) 2024 Yu MA, Banta AB, Ward RD, Prasad NK, Kwon MS, Rosenberg OS, Peters JM
• Codelivery of synergistic antimicrobials with polyelectrolyte nanocomplexes to treat bacterial biofilms and lung infections.
  Science advances 2023 Finbloom JA, Raghavan P, Kwon M, Kharbikar BN, Yu MA, Desai TA
• Human Fetal Tissue Regulation. Impact on Pediatric and Adult Respiratory-related Research.
  Annals of the American Thoracic Society 2021 Al Alam D, Ballard PL, Jourdan Le Saux C, Ingram JL, Mariani TJ, Moore NS, Weiss DJ, Yu M
• Antibiotic adverse reactions in adult cystic fibrosis patients.
  The journal of allergy and clinical immunology. In practice 2020 Anstey KM, Lee M, Dawson D, Jue V, Budzik JM, Yu M, Kleinhenz ME, Otani IM
• Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation.
  The Journal of clinical investigation 2020 Ortiz-Muñoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR

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• Sensing Living Bacteria in Vivo Using d-Alanine-Derived 11C Radiotracers.
  ACS central science 2020 Parker MFL, Luu JM, Schulte B, Huynh TL, Stewart MN, Sriram R, Yu MA, Jivan S, Turnbaugh PJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM
• Modulating Pathogenesis with Mobile-CRISPRi.
  Journal of bacteriology 2019 Qu J, Prasad NK, Yu MA, Chen S, Lyden A, Herrera N, Silvis MR, Crawford E, Looney MR, Peters JM, Rosenberg OS
• Two tyrosyl radicals stabilize high oxidation states in cytochrome C oxidase for efficient energy conservation and proton translocation.
  Journal of the American Chemical Society 2012 Yu MA, Egawa T, Shinzawa-Itoh K, Yoshikawa S, Guallar V, Yeh SR, Rousseau DL, Gerfen GJ
• Radical formation in cytochrome c oxidase.
  Biochimica et biophysica acta 2011 Yu MA, Egawa T, Shinzawa-Itoh K, Yoshikawa S, Yeh SR, Rousseau DL, Gerfen GJ
• Differential effects of glutamate-286 mutations in the aa(3)-type cytochrome c oxidase from Rhodobacter sphaeroides and the cytochrome bo(3) ubiquinol oxidase from Escherichia coli.
  Biochimica et biophysica acta 2011 Egawa T, Ganesan K, Lin MT, Yu MA, Hosler JP, Yeh SR, Rousseau DL, Gennis RB
• EPR characterization of ascorbyl and sulfur dioxide anion radicals trapped during the reaction of bovine Cytochrome c Oxidase with molecular oxygen.
  Journal of magnetic resonance (San Diego, Calif. : 1997) 2009 Yu MA, Egawa T, Yeh SR, Rousseau DL, Gerfen GJ