Michael Rowbotham, MD
Professor
Anesthesia
School of Medicine

Grants and Projects

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• General Clinical Research Center, NIH, 1974-2009
• Mechanisms of Pain and Analgesia, NIH, 1985-2005
• Chronic Neuropathic Pain Mechanisms and Management, NIH, 2000-2005
• Pain &Neural Dysfunction from Acute Herpes Zoster, NIH, 2000-2005
• Drug Dependence Clinical Research Program, NIH, 1978-2000

Publications (146)

Top publication keywords:
Clinical Trials as TopicNeuralgiaHerpes ZosterChronic PainDiabetic NeuropathiesAnalgesicsPain MeasurementPainHyperalgesiaAnalgesics, OpioidLidocaineComplex Regional Pain SyndromesNeuralgia, PostherpeticDrug ToleranceCapsaicin

• Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations.
  Pain 2023 Haroutounian S, Holzer KJ, Kerns RD, Veasley C, Dworkin RH, Turk DC, Carman KL, Chambers CT, Cowan P, Edwards RR, Eisenach JC, Farrar JT, Ferguson M, Forsythe LP, Freeman R, Gewandter JS, Gilron I, …
• Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement.
  Pain 2023 Hohenschurz-Schmidt DJ, Cherkin D, Rice ASC, Dworkin RH, Turk DC, McDermott MP, Bair MJ, DeBar LL, Edwards RR, Farrar JT, Kerns RD, Markman JD, Rowbotham MC, Sherman KJ, Wasan AD, Cowan P, Desjardins …
• Pitfalls and Rewards of Setting Up a Liquid Biopsy Approach for the Detection of Driver Mutations in Circulating Tumor DNAs: Our Institutional Experience.
  Journal of personalized medicine 2022 Chen M, Jian D, Sidorov M, Woo RWL, Kim A, Stone DE, Nazarian A, Nosrati M, Ice RJ, de Semir D, Dar AA, Luštrik R, Kokošar J, Ausec L, Rowbotham MC, Tranah GJ, Kashani-Sabet M, Soroceanu L, McAllister…
• Optimizing and Accelerating the Development of Precision Pain Treatments for Chronic Pain: IMMPACT Review and Recommendations.
  The journal of pain 2022 Edwards RR, Schreiber KL, Dworkin RH, Turk DC, Baron R, Freeman R, Jensen TS, Latremoliere A, Markman JD, Rice ASC, Rowbotham M, Staud R, Tate S, Woolf CJ, Andrews NA, Carr DB, Colloca L, Cosma-Roman …
• Combination pharmacotherapy for the treatment of neuropathic pain in adults: systematic review and meta-analysis.
  Pain 2022 Balanaser M, Carley M, Baron R, Finnerup NB, Moore RA, Rowbotham MC, Chaparro LE, Gilron I

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• Research approaches for evaluating opioid sparing in clinical trials of acute and chronic pain treatments: Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials recommendations.
  Pain 2021 Gewandter JS, Smith SM, Dworkin RH, Turk DC, Gan TJ, Gilron I, Hertz S, Katz NP, Markman JD, Raja SN, Rowbotham MC, Stacey BR, Strain EC, Ward DS, Farrar JT, Kroenke K, Rathmell JP, Rauck R, Brown C, …
• Benefit-risk assessment and reporting in clinical trials of chronic pain treatments: IMMPACT recommendations.
  Pain 2021 Kleykamp BA, Dworkin RH, Turk DC, Bhagwagar Z, Cowan P, Eccleston C, Ellenberg SS, Evans SR, Farrar JT, Freeman RL, Garrison LP, Gewandter JS, Goli V, Iyengar S, Jadad AR, Jensen MP, Junor R, Katz NP,…
• Cannabinoids, cannabis, and cannabis-based medicine for pain management: a systematic review of randomised controlled trials.
  Pain 2021 Fisher E, Moore RA, Fogarty AE, Finn DP, Finnerup NB, Gilron I, Haroutounian S, Krane E, Rice ASC, Rowbotham M, Wallace M, Eccleston C
• Cannabinoids, cannabis, and cannabis-based medicines for pain management: an overview of systematic reviews.
  Pain 2021 Moore RA, Fisher E, Finn DP, Finnerup NB, Gilron I, Haroutounian S, Krane E, Rice ASC, Rowbotham M, Wallace M, Eccleston C
• International Association for the Study of Pain Presidential Task Force on Cannabis and Cannabinoid Analgesia: research agenda on the use of cannabinoids, cannabis, and cannabis-based medicines for pain management.
  Pain 2021 Haroutounian S, Arendt-Nielsen L, Belton J, Blyth FM, Degenhardt L, Di Forti M, Eccleston C, Finn DP, Finnerup NB, Fisher E, Fogarty AE, Gilron I, Hohmann AG, Kalso E, Krane E, Mohiuddin M, Moore RA, …
• Societal issues and policy implications related to the use of cannabinoids, cannabis, and cannabis-based medicines for pain management.
  Pain 2021 Haroutounian S, Gilron I, Belton J, Degenhardt L, Di Forti M, Finn DP, Fogarty A, Kalso E, Krane E, Moore RA, Rowbotham M, Wallace M, Rice ASC
• A year like no other: introduction to a special issue on COVID-19 and pain.
  Pain reports 2021 Rowbotham MC, Arendt-Nielsen L
• Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations.
  Pain 2020 Smith SM, Dworkin RH, Turk DC, McDermott MP, Eccleston C, Farrar JT, Rowbotham MC, Bhagwagar Z, Burke LB, Cowan P, Ellenberg SS, Evans SR, Freeman RL, Garrison LP, Iyengar S, Jadad A, Jensen MP, Junor…
• Evolution of Analgesic Tolerance and Opioid-Induced Hyperalgesia Over 6 Months: Double-Blind Randomized Trial Incorporating Experimental Pain Models.
  The journal of pain 2020 Rowbotham MC, Wallace M
• Improving Study Conduct and Data Quality in Clinical Trials of Chronic Pain Treatments: IMMPACT Recommendations.
  The journal of pain 2019 Gewandter JS, Dworkin RH, Turk DC, Devine EG, Hewitt D, Jensen MP, Katz NP, Kirkwood AA, Malamut R, Markman JD, Vrijens B, Burke L, Campbell JN, Carr DB, Conaghan PG, Cowan P, Doyle MK, Edwards RR, …
• SUMMIT-07: a randomized trial of NKTR-181, a new molecular entity, full mu-opioid receptor agonist for chronic low-back pain.
  Pain 2019 Markman J, Gudin J, Rauck R, Argoff C, Rowbotham M, Agaiby E, Gimbel J, Katz N, Doberstein SK, Tagliaferri M, Lu L, Siddhanti S, Hale M
• Cannabinoids, cannabis, and cannabis-based medicine for pain management: a protocol for an overview of systematic reviews and a systematic review of randomised controlled trials.
  Pain reports 2019 Fisher E, Eccleston C, Degenhardt L, Finn DP, Finnerup NB, Gilron I, Haroutounian S, Krane E, Rice ASC, Rowbotham M, Wallace M, Moore RA
• The IASP classification of chronic pain for ICD-11: chronic neuropathic pain.
  Pain 2019 Scholz J, Finnerup NB, Attal N, Aziz Q, Baron R, Bennett MI, Benoliel R, Cohen M, Cruccu G, Davis KD, Evers S, First M, Giamberardino MA, Hansson P, Kaasa S, Korwisi B, Kosek E, Lavand'homme P, …
• Evaluation of composite responder outcomes of pain intensity and physical function in neuropathic pain clinical trials: an ACTTION individual patient data analysis.
  Pain 2018 Patel KV, Allen R, Burke L, Farrar JT, Gewandter JS, Gilron I, Katz NP, Markman JD, Marshall SF, Resnick M, Rice ASC, Rowbotham MC, Smith SM, Vanhove GF, Wasan AD, Zhang S, Dworkin RH, Turk DC
• Natural history of pain associated with melanoma surgery.
  Pain reports 2018 Slagelse C, Munch T, Glazer C, Greene K, Finnerup NB, Kashani-Sabet M, Leong SP, Petersen KL, Rowbotham MC
• Ethical considerations in the design, execution, and analysis of clinical trials of chronic pain treatments.
  Pain reports 2018 Rowbotham MC, McDermott MP
• The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions.
  The journal of pain 2017 Kent ML, Tighe PJ, Belfer I, Brennan TJ, Bruehl S, Brummett CM, Buckenmaier CC, Buvanendran A, Cohen RI, Desjardins P, Edwards D, Fillingim R, Gewandter J, Gordon DB, Hurley RW, Kehlet H, Loeser JD, …
• The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions.
  Pain medicine (Malden, Mass.) 2017 Kent ML, Tighe PJ, Belfer I, Brennan TJ, Bruehl S, Brummett CM, Buckenmaier CC, Buvanendran A, Cohen RI, Desjardins P, Edwards D, Fillingim R, Gewandter J, Gordon DB, Hurley RW, Kehlet H, Loeser JD, …
• Informed Consent.
  The New England journal of medicine 2017 Grady C, Cummings SR, Rowbotham MC, McConnell MV, Ashley EA, Kang G
• The Potential Role of Sensory Testing, Skin Biopsy, and Functional Brain Imaging as Biomarkers in Chronic Pain Clinical Trials: IMMPACT Considerations.
  The journal of pain 2017 Smith SM, Dworkin RH, Turk DC, Baron R, Polydefkis M, Tracey I, Borsook D, Edwards RR, Harris RE, Wager TD, Arendt-Nielsen L, Burke LB, Carr DB, Chappell A, Farrar JT, Freeman R, Gilron I, Goli V, …
• Reporting of data monitoring boards in publications of randomized clinical trials is often deficient: ACTTION systematic review.
  Journal of clinical epidemiology 2017 Gewandter JS, Kitt RA, Hunsinger MR, Poku J, Lozano J, Chaudari J, Evans S, Gross RA, McDermott MP, Rowbotham MC, Turk DC, Dworkin RH
• Adverse Event Reporting in Clinical Trials of Intravenous and Invasive Pain Treatments: An ACTTION Systematic Review.
  The journal of pain 2016 Williams MR, McKeown A, Pressman Z, Hunsinger M, Lee K, Coplan P, Gilron I, Katz NP, McDermott MP, Raja SN, Rappaport BA, Rowbotham MC, Turk DC, Dworkin RH, Smith SM
• Mitochondrial DNA Heteroplasmy Associations With Neurosensory and Mobility Function in Elderly Adults.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2015 Tranah GJ, Yaffe K, Katzman SM, Lam ET, Pawlikowska L, Kwok PY, Schork NJ, Manini TM, Kritchevsky S, Thomas F, Newman AB, Harris TB, Coleman AL, Gorin MB, Helzner EP, Rowbotham MC, Browner WS, …
• Tricyclic antidepressants and opioids-better together?
  Pain 2015 Rowbotham MC
• Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis.
  The Lancet. Neurology 2015 Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, Gilron I, Haanpää M, Hansson P, Jensen TS, Kamerman PR, Lund K, Moore A, Raja SN, Rice AS, Rowbotham M, Sena E, Siddall P, Smith …
• Results availability for analgesic device, complex regional pain syndrome, and post-stroke pain trials: comparing the RReADS, RReACT, and RReMiT databases.
  Pain 2015 Dufka FL, Munch T, Dworkin RH, Rowbotham MC
• Reporting of sample size calculations in analgesic clinical trials: ACTTION systematic review.
  The journal of pain 2014 McKeown A, Gewandter JS, McDermott MP, Pawlowski JR, Poli JJ, Rothstein D, Farrar JT, Gilron I, Katz NP, Lin AH, Rappaport BA, Rowbotham MC, Turk DC, Dworkin RH, Smith SM
• Data interpretation in analgesic clinical trials with statistically nonsignificant primary analyses: an ACTTION systematic review.
  The journal of pain 2014 Gewandter JS, McKeown A, McDermott MP, Dworkin JD, Smith SM, Gross RA, Hunsinger M, Lin AH, Rappaport BA, Rice AS, Rowbotham MC, Williams MR, Turk DC, Dworkin RH
• Reporting of intention-to-treat analyses in recent analgesic clinical trials: ACTTION systematic review and recommendations.
  Pain 2014 Gewandter JS, McDermott MP, McKeown A, Smith SM, Pawlowski JR, Poli JJ, Rothstein D, Williams MR, Bujanover S, Farrar JT, Gilron I, Katz NP, Rowbotham MC, Turk DC, Dworkin RH
• How transparent are migraine clinical trials? Repository of Registered Migraine Trials (RReMiT).
  Neurology 2014 Dufka FL, Dworkin RH, Rowbotham MC
• Research designs for proof-of-concept chronic pain clinical trials: IMMPACT recommendations.
  Pain 2014 Gewandter JS, Dworkin RH, Turk DC, McDermott MP, Baron R, Gastonguay MR, Gilron I, Katz NP, Mehta C, Raja SN, Senn S, Taylor C, Cowan P, Desjardins P, Dimitrova R, Dionne R, Farrar JT, Hewitt DJ, …
• Effect of variability in the 7-day baseline pain diary on the assay sensitivity of neuropathic pain randomized clinical trials: an ACTTION study.
  Pain 2014 Farrar JT, Troxel AB, Haynes K, Gilron I, Kerns RD, Katz NP, Rappaport BA, Rowbotham MC, Tierney AM, Turk DC, Dworkin RH
• RReACT goes global: perils and pitfalls of constructing a global open-access database of registered analgesic clinical trials and trial results.
  Pain 2014 Munch T, Dufka FL, Greene K, Smith SM, Dworkin RH, Rowbotham MC
• Persistent postoperative pain and sensory changes following lymph node excision in melanoma patients: a topical review.
  Melanoma research 2014 Slagelse C, Petersen KL, Dahl JB, Finnerup K, Greene K, Leong SP, Levine J, Rowbotham M, Werner MU, Finnerup NB
• Correction: Shaped Magnetic Field Pulses by Multi-Coil Repetitive Transcranial Magnetic Stimulation (rTMS) Differentially Modulate Anterior Cingulate Cortex Responses and Pain in Volunteers and Fibromyalgia Patients.
  Molecular pain 2014 Tzabazis A, Aparici CM, Rowbotham MC, Schneider MB, Etkin A, Yeomans DC
• Abuse liability measures for use in analgesic clinical trials in patients with pain: IMMPACT recommendations.
  Pain 2013 O'Connor AB, Turk DC, Dworkin RH, Katz NP, Colucci R, Haythornthwaite JA, Klein M, O'Brien C, Posner K, Rappaport BA, Reisfield G, Adams EH, Balster RL, Bigelow GE, Burke LB, Comer SD, Cone E, Cowan P…
• Discrepancies between registered and published primary outcome specifications in analgesic trials: ACTTION systematic review and recommendations.
  Pain 2013 Smith SM, Wang AT, Pereira A, Chang DR, McKeown A, Greene K, Rowbotham MC, Burke LB, Coplan P, Gilron I, Hertz SH, Katz NP, Lin AH, McDermott MP, Papadopoulos EJ, Rappaport BA, Sweeney M, Turk DC, …
• Shaped magnetic field pulses by multi-coil repetitive transcranial magnetic stimulation (rTMS) differentially modulate anterior cingulate cortex responses and pain in volunteers and fibromyalgia patients.
  Molecular pain 2013 Tzabazis A, Aparici CM, Rowbotham MC, Schneider MB, Etkin A, Yeomans DC
• Does naloxone reinstate secondary hyperalgesia in humans after resolution of a burn injury? A placebo-controlled, double-blind, randomized, cross-over study.
  PloS one 2013 Pereira MP, Werner MU, Ringsted TK, Rowbotham MC, Taylor BK, Dahl JB
• Assay sensitivity and study features in neuropathic pain trials: an ACTTION meta-analysis.
  Neurology 2013 Dworkin RH, Turk DC, Peirce-Sandner S, He H, McDermott MP, Farrar JT, Katz NP, Lin AH, Rappaport BA, Rowbotham MC
• Healthy volunteers can be phenotyped using cutaneous sensitization pain models.
  PloS one 2013 Werner MU, Petersen KL, Rowbotham MC, Dahl JB
• Natural history of herpes zoster: late follow-up of 3.9 years (n=43) and 7.7 years (n=10).
  Pain 2013 Reda H, Greene K, Rice FL, Rowbotham MC, Petersen KL
• Adverse event assessment, analysis, and reporting in recent published analgesic clinical trials: ACTTION systematic review and recommendations.
  Pain 2013 Smith SM, Wang AT, Katz NP, McDermott MP, Burke LB, Coplan P, Gilron I, Hertz SH, Lin AH, Rappaport BA, Rowbotham MC, Sampaio C, Sweeney M, Turk DC, Dworkin RH
• Can pragmatic trials help us better understand chronic pain and improve treatment?
  Pain 2013 Rowbotham MC, Gilron I, Glazer C, Rice ASC, Smith BH, Stewart WF, Wasan AD
• Interactive informed consent: randomized comparison with paper consents.
  PloS one 2013 Rowbotham MC, Astin J, Greene K, Cummings SR
• Neuropathic pain needs systematic classification.
  European journal of pain (London, England) 2013 Finnerup NB, Scholz J, Attal N, Baron R, Haanpää M, Hansson P, Raja SN, Rice AS, Rief W, Rowbotham MC, Simpson DM, Treede RD
• Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations.
  Pain 2012 Comer SD, Zacny JP, Dworkin RH, Turk DC, Bigelow GE, Foltin RW, Jasinski DR, Sellers EM, Adams EH, Balster R, Burke LB, Cerny I, Colucci RD, Cone E, Cowan P, Farrar JT, Haddox DJ, Haythornthwaite JA, …
• Adherence to CONSORT harms-reporting recommendations in publications of recent analgesic clinical trials: an ACTTION systematic review.
  Pain 2012 Smith SM, Chang DR, Pereira A, Shah N, Gilron I, Katz NP, Lin AH, McDermott MP, Rappaport BA, Rowbotham MC, Sampaio C, Turk DC, Dworkin RH
• A snapshot and scorecard for analgesic clinical trials for chronic pain: the RReACT database.
  Pain 2012 Greene K, Dworkin RH, Rowbotham MC
• Randomized control trial of topical clonidine for treatment of painful diabetic neuropathy.
  Pain 2012 Campbell CM, Kipnes MS, Stouch BC, Brady KL, Kelly M, Schmidt WK, Petersen KL, Rowbotham MC, Campbell JN
• Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations.
  Pain 2012 Dworkin RH, Turk DC, Peirce-Sandner S, Burke LB, Farrar JT, Gilron I, Jensen MP, Katz NP, Raja SN, Rappaport BA, Rowbotham MC, Backonja MM, Baron R, Bellamy N, Bhagwagar Z, Costello A, Cowan P, Fang …
• Efficacy and safety of the α4β2 neuronal nicotinic receptor agonist ABT-894 in patients with diabetic peripheral neuropathic pain.
  Pain 2012 Rowbotham MC, Arslanian A, Nothaft W, Duan RW, Best AE, Pritchett Y, Zhou Q, Stacey BR
• How to reduce the incidence of neuropathic pain: sentinel node biopsy for diagnosis of metastatic malignant melanoma.
  Pain 2011 Rowbotham MC, Leong SPL
• Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial.
  Pain 2011 Rowbotham MC, Nothaft W, Duan RW, Wang Y, Faltynek C, McGaraughty S, Chu KL, Svensson P
• Effect of a single dose of pregabalin on herpes zoster pain.
  Trials 2011 Jensen-Dahm C, Rowbotham MC, Reda H, Petersen KL
• Evidence-based clinical trial design for chronic pain pharmacotherapy: a blueprint for ACTION.
  Pain 2010 Dworkin RH, Turk DC, Katz NP, Rowbotham MC, Peirce-Sandner S, Cerny I, Clingman CS, Eloff BC, Farrar JT, Kamp C, McDermott MP, Rappaport BA, Sanhai WR
• NeuPSIG guidelines on neuropathic pain assessment.
  Pain 2010 Haanpää M, Attal N, Backonja M, Baron R, Bennett M, Bouhassira D, Cruccu G, Hansson P, Haythornthwaite JA, Iannetti GD, Jensen TS, Kauppila T, Nurmikko TJ, Rice ASC, Rowbotham M, Serra J, Sommer C, …
• Natural history of cutaneous innervation following herpes zoster.
  Pain 2010 Petersen KL, Rice FL, Farhadi M, Reda H, Rowbotham MC
• Natural history of sensory function after herpes zoster.
  Pain 2010 Petersen KL, Rowbotham MC
• Opioid pharmacotherapy for chronic non-cancer pain in the United States: a research guideline for developing an evidence-base.
  The journal of pain 2010 Chapman CR, Lipschitz DL, Angst MS, Chou R, Denisco RC, Donaldson GW, Fine PG, Foley KM, Gallagher RM, Gilson AM, Haddox JD, Horn SD, Inturrisi CE, Jick SS, Lipman AG, Loeser JD, Noble M, Porter L, …
• Pain's policy on the spinal administration of drugs.
  Pain 2010 Rowbotham MC
• The case for publishing 'negative' clinical trials.
  Pain 2009 Rowbotham MC
• Clinical effectiveness: an approach to clinical trial design more relevant to clinical practice, acknowledging the importance of individual differences.
  Pain 2009 Moore RA, Derry S, McQuay HJ, Straube S, Aldington D, Wiffen P, Bell RF, Kalso E, Rowbotham MC, ACTINPAIN writing group of the IASP Special Interest Group (SIG) on Systematic Reviews in Pain Relie
• A randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of ABT-594 in patients with diabetic peripheral neuropathic pain.
  Pain 2009 Rowbotham MC, Duan RW, Thomas J, Nothaft W, Backonja MM
• Predicting therapeutic efficacy - experimental pain in human subjects.
  Brain research reviews 2008 Chizh BA, Priestley T, Rowbotham M, Schaffler K
• The impact of selective publication on clinical research in pain.
  Pain 2008 Rowbotham MC
• Naltrexone aversion and treatment efficacy are greatest in humans and rats that actively consume high levels of alcohol.
  Neurobiology of disease 2008 Mitchell JM, Bergren LJ, Chen KS, Rowbotham MC, Fields HL
• How should treatment results from clinical practice be reported?
  Pain 2008 Rowbotham MC
• Placebo response in neuropathic pain trials.
  Pain 2008 Quessy SN, Rowbotham MC
• Pregabalin for postherpetic neuralgia: placebo-controlled trial of fixed and flexible dosing regimens on allodynia and time to onset of pain relief.
  The journal of pain 2008 Stacey BR, Barrett JA, Whalen E, Phillips KF, Rowbotham MC
• Changes in morphine analgesia and side effects during daily subcutaneous administration in healthy volunteers.
  Pain 2007 Petersen KL, Meadoff T, Press S, Peters MM, LeComte MD, Rowbotham MC
• How effective is long-term opioid therapy for chronic noncancer pain?
  The Clinical journal of pain 2007 Rowbotham MC, Lindsey CD
• Relief of post-herpetic neuralgia by surgical removal of painful skin: 5 years later.
  Pain 2007 Petersen KL, Rowbotham MC
• Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial.
  Neurology 2007 Abrams DI, Jay CA, Shade SB, Vizoso H, Reda H, Press S, Kelly ME, Rowbotham MC, Petersen KL
• The Asp40 mu-opioid receptor allele does not predict naltrexone treatment efficacy in heavy drinkers.
  Journal of clinical psychopharmacology 2007 Mitchell JM, Fields HL, White RL, Meadoff TM, Joslyn G, Rowbotham MC
• Duloxetine for the management of diabetic peripheral neuropathic pain: evidence-based findings from post hoc analysis of three multicenter, randomized, double-blind, placebo-controlled, parallel-group studies.
  Clinical therapeutics 2007 Kajdasz DK, Iyengar S, Desaiah D, Backonja MM, Farrar JT, Fishbain DA, Jensen TS, Rowbotham MC, Sang CN, Ziegler D, McQuay HJ
• Recommendations for the management of herpes zoster.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007 Dworkin RH, Johnson RW, Breuer J, Gnann JW, Levin MJ, Backonja M, Betts RF, Gershon AA, Haanpaa ML, McKendrick MW, Nurmikko TJ, Oaklander AL, Oxman MN, Pavan-Langston D, Petersen KL, Rowbotham MC, …
• Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers.
  The journal of pain 2006 Frymoyer AR, Rowbotham MC, Petersen KL
• Natural history of pain following herpes zoster.
  Pain 2006 Thyregod HG, Rowbotham MC, Peters M, Possehn J, Berro M, Petersen KL
• Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients.
  Neurology 2006 Leung JM, Sands LP, Rico M, Petersen KL, Rowbotham MC, Dahl JB, Ames C, Chou D, Weinstein P
• Quantitative sensory testing scaled up for multicenter clinical research networks: a promising start.
  Pain 2006 Petersen KL, Rowbotham MC
• Pharmacologic management of complex regional pain syndrome.
  The Clinical journal of pain 2006 Rowbotham MC
• Mechanisms of neuropathic pain and their implications for the design of clinical trials.
  Neurology 2005 Rowbotham MC
• Treatment response in antidepressant-naïve postherpetic neuralgia patients: double-blind, randomized trial.
  The journal of pain 2005 Rowbotham MC, Reisner LA, Davies PS, Fields HL
• Does pain change the brain?
  Neurology 2005 Birklein F, Rowbotham MC
• Is fibromyalgia a neuropathic pain syndrome?
  The Journal of rheumatology. Supplement 2005 Rowbotham MC
• Pregabalin for the treatment of fibromyalgia syndrome: results of a randomized, double-blind, placebo-controlled trial.
  Arthritis and rheumatism 2005 Crofford LJ, Rowbotham MC, Mease PJ, Russell IJ, Dworkin RH, Corbin AE, Young JP, LaMoreaux LK, Martin SA, Sharma U, Pregabalin 1008-105 Study Group
• Venlafaxine extended release in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled study.
  Pain 2004 Rowbotham MC, Goli V, Kunz NR, Lei D
• Complex regional pain syndrome-like symptoms during herpes zoster.
  Pain 2004 Berry JD, Rowbotham MC, Petersen KL
• Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations.
  Archives of neurology 2003 Dworkin RH, Backonja M, Rowbotham MC, Allen RR, Argoff CR, Bennett GJ, Bushnell MC, Farrar JT, Galer BS, Haythornthwaite JA, Hewitt DJ, Loeser JD, Max MB, Saltarelli M, Schmader KE, Stein C, Thompson …
• Pilot tolerability and effectiveness study of levetiracetam for postherpetic neuralgia.
  Neurology 2003 Rowbotham MC, Manville NS, Ren J
• A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization.
  The journal of pain 2003 Petersen KL, Maloney A, Hoke F, Dahl JB, Rowbotham MC
• Oral opioid therapy for chronic peripheral and central neuropathic pain.
  The New England journal of medicine 2003 Rowbotham MC, Twilling L, Davies PS, Reisner L, Taylor K, Mohr D
• A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain.
  Neurology 2002 Wallace MS, Rowbotham MC, Katz NP, Dworkin RH, Dotson RM, Galer BS, Rauck RL, Backonja MM, Quessy SN, Meisner PD
• The lidocaine patch 5% effectively treats all neuropathic pain qualities: results of a randomized, double-blind, vehicle-controlled, 3-week efficacy study with use of the neuropathic pain scale.
  The Clinical journal of pain 2002 Galer BS, Jensen MP, Ma T, Davies PS, Rowbotham MC
• Gabapentin suppresses cutaneous hyperalgesia following heat-capsaicin sensitization.
  Anesthesiology 2002 Dirks J, Petersen KL, Rowbotham MC, Dahl JB
• Relief of post-herpetic neuralgia by surgical removal of painful skin.
  Pain 2002 Petersen KL, Rice FL, Suess F, Berro M, Rowbotham MC
• A multicenter, double-blind, randomized, placebo-controlled crossover evaluation of a short course of 4030W92 in patients with chronic neuropathic pain.
  The journal of pain 2002 Wallace MS, Rowbotham M, Bennett GJ, Jensen TS, Pladna R, Quessy S
• Effect of systemic adenosine on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers.
  Regional anesthesia and pain medicine 2001 Dirks J, Petersen KL, Rowbotham MC, Dahl JB
• Effect of remifentanil on pain and secondary hyperalgesia associated with the heat--capsaicin sensitization model in healthy volunteers.
  Anesthesiology 2001 Petersen KL, Jones B, Segredo V, Dahl JB, Rowbotham MC
• Capsaicin evoked pain and allodynia in post-herpetic neuralgia.
  Pain 2000 Petersen KL, Fields HL, Brennum J, Sandroni P, Rowbotham MC
• Lack of efficacy of riluzole in the treatment of peripheral neuropathic pain conditions.
  Neurology 2000 Galer BS, Twilling LL, Harle J, Cluff RS, Friedman E, Rowbotham MC
• The effect of systemic lidocaine on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers.
  Anesthesia and analgesia 2000 Dirks J, Fabricius P, Petersen KL, Rowbotham MC, Dahl JB
• Will ion-channel blockers be useful for management of nonneuropathic pain?
  The journal of pain 2000 Petersen KL, Rowbotham MC
• Herpes zoster.
  The New England journal of medicine 2000 Dworkin RH, Galer BS, Rowbotham MC
• Topical diclofenac patch relieves minor sports injury pain: results of a multicenter controlled clinical trial.
  Journal of pain and symptom management 2000 Galer BS, Rowbotham M, Perander J, Devers A, Friedman E
• Quantitation of levorphanol in human plasma at subnanogram per milliliter levels using capillary gas chromatography with electron-capture detection.
  Journal of chromatography. B, Biomedical sciences and applications 1999 Everhart ET, Shwonek P, Jacob P, Rowbotham MC, Jones RT
• A new human experimental pain model: the heat/capsaicin sensitization model.
  Neuroreport 1999 Petersen KL, Rowbotham MC
• Topical lidocaine patch relieves postherpetic neuralgia more effectively than a vehicle topical patch: results of an enriched enrollment study.
  Pain 1999 Galer BS, Rowbotham MC, Perander J, Friedman E
• Effect of sympathetic activity on capsaicin-evoked pain, hyperalgesia, and vasodilatation.
  Neurology 1999 Baron R, Wasner G, Borgstedt R, Hastedt E, Schulte H, Binder A, Kopper F, Rowbotham M, Levine JD, Fields HL
• Effect of EMLA pre-treatment on capsaicin-induced burning and hyperalgesia.
  Acta dermato-venereologica 1999 Yosipovitch G, Maibach HI, Rowbotham MC
• Cocaine metabolite kinetics in the newborn.
  Journal of analytical toxicology 1999 Dempsey D, Jacob P, Partridge JC, Jones RT, Panganiban K, Rowbotham MC
• Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial.
  JAMA 1998 Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L
• Pain caused by herpes zoster infection.
  Neurologic clinics 1998 Cluff RS, Rowbotham MC
• Postherpetic neuralgia: irritable nociceptors and deafferentation.
  Neurobiology of disease 1998 Fields HL, Rowbotham M, Baron R
• Complex regional pain syndrome type I (reflex sympathetic dystrophy): more than a myth.
  Neurology 1998 Rowbotham MC
• Cocaine, nicotine, caffeine, and metabolite plasma concentrations in neonates.
  Journal of analytical toxicology 1998 Dempsey DA, Partridge JC, Jones RT, Rowbotham MC
• Effect of adrenergic receptor activation on post-herpetic neuralgia pain and sensory disturbances.
  Pain 1997 Choi B, Rowbotham MC
• Response to intravenous lidocaine infusion predicts subsequent response to oral mexiletine: a prospective study.
  Journal of pain and symptom management 1996 Galer BS, Harle J, Rowbotham MC
• Venlafaxine hydrochloride and chronic pain.
  The Western journal of medicine 1996 Taylor K, Rowbotham MC
• Lidocaine patch: double-blind controlled study of a new treatment method for post-herpetic neuralgia.
  Pain 1996 Rowbotham MC, Davies PS, Verkempinck C, Galer BS
• The relationship of pain, allodynia and thermal sensation in post-herpetic neuralgia.
  Brain : a journal of neurology 1996 Rowbotham MC, Fields HL
• Cutaneous innervation density in the allodynic form of postherpetic neuralgia.
  Neurobiology of disease 1996 Rowbotham MC, Yosipovitch G, Connolly MK, Finlay D, Forde G, Fields HL
• Chronic pain: from theory to practical management.
  Neurology 1995 Rowbotham MC
• Topical lidocaine gel relieves postherpetic neuralgia.
  Annals of neurology 1995 Rowbotham MC, Davies PS, Fields HL
• The interpretation of pain relief and sensory changes following sympathetic blockade.
  Brain : a journal of neurology 1994 Dellemijn PL, Fields HL, Allen RR, McKay WR, Rowbotham MC
• Postherpetic neuralgia.
  Seminars in neurology 1994 Rowbotham MC
• Managing post-herpetic neuralgia with opioids and local anesthetics.
  Annals of neurology 1994 Rowbotham MC
• Response to intravenous lidocaine infusion differs based on clinical diagnosis and site of nervous system injury.
  Neurology 1993 Galer BS, Miller KV, Rowbotham MC
• Treatment of postherpetic neuralgia.
  Seminars in dermatology 1992 Rowbotham MC
• Treatment of inflammatory, neuropathic and sympathetically maintained pain in a patient with Sjögren's syndrome.
  Pain 1992 Galer BS, Rowbotham MC, Miller KV, Walton A, Fields HL
• Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia.
  Neurology 1991 Rowbotham MC, Reisner-Keller LA, Fields HL
• Neurologic consequences of cocaine use.
  Annual review of medicine 1990 Rowbotham MC, Lowenstein DH
• Post-herpetic neuralgia: the relation of pain complaint, sensory disturbance, and skin temperature.
  Pain 1989 Rowbotham MC, Fields HL
• Topical lidocaine reduces pain in post-herpetic neuralgia.
  Pain 1989 Rowbotham MC, Fields HL
• Thalamomesencephalic strokes after cocaine abuse.
  Neurology 1989 Rowley HA, Lowenstein DH, Rowbotham MC, Simon RP
• Neurologic aspects of cocaine abuse.
  The Western journal of medicine 1988 Rowbotham MC
• Acute neurologic and psychiatric complications associated with cocaine abuse.
  The American journal of medicine 1987 Lowenstein DH, Massa SM, Rowbotham MC, Collins SD, McKinney HE, Simon RP
• Cocaine-calcium channel antagonist interactions.
  Psychopharmacology 1987 Rowbotham MC, Hooker WD, Mendelson J, Jones RT
• Trazodone-oral cocaine interactions.
  Archives of general psychiatry 1984 Rowbotham MC, Jones RT, Benowitz NL, Jacob P
• Failure of naloxone to reverse apomorphine effects in humans.
  Psychoneuroendocrinology 1983 Rowbotham MC, Joseph MS, Jones RT, Keil LC