Michael Metrick, MD, PhD
RESIDENT
Pathology
School of Medicine

Education & Training

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• MD Medicine University of Illinois at Chicago 05/2024
• PhD Chemistry University of Cambridge 10/2021
• BS Chemistry James Madison University 05/2013

Interests

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• Drug discovery and design
• Neurodegeneration
• Assay development
• Protein misfolding
• Biophysics

Websites

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• CV and active projects (michaelmetrick.org)

Publications (17)

Top publication keywords:
Alzheimer DiseaseProtein Aggregation, PathologicalProtein UnfoldingRec A RecombinasesBiological AssayProtein AggregatesTemperaturetau ProteinsPrion Diseasesalpha-SynucleinCreutzfeldt-Jakob SyndromeBrainPick Disease of the BrainPrion ProteinsTauopathies

• A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases.
  Acta neuropathologica communications 2020 Metrick MA, Ferreira NDC, Saijo E, Kraus A, Newell K, Zanusso G, Vendruscolo M, Ghetti B, Caughey B
• 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.
  Acta neuropathologica 2019 Saijo E, Metrick MA, Koga S, Parchi P, Litvan I, Spina S, Boxer A, Rojas JC, Galasko D, Kraus A, Rossi M, Newell K, Zanusso G, Grinberg LT, Seeley WW, Ghetti B, Dickson DW, Caughey B
• Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease.
  Acta neuropathologica 2018 Kraus A, Saijo E, Metrick MA, Newell K, Sigurdson CJ, Zanusso G, Ghetti B, Caughey B
• Classification of tauopathies from human brain homogenates through salt-modulated tau amplification.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2026 Santambrogio A, Metrick MA, Xu P, Gallagher NCT, Koga S, Ghetti B, Dickson DW, Caughey B, Vendruscolo M
• Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau.
  FEBS letters 2025 Santambrogio A, Lövestam S, Metrick MA, Löhr T, Xu P, Gallagher NCT, Ghetti B, Caughey B, Scheres SHW, Vendruscolo M

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• Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay.
  Journal of the American Chemical Society 2025 Santambrogio A, Horne RI, Metrick MA, Gallagher NCT, Brotzakis ZF, Rinauro D, Vourkou E, Papanikolopoulou K, Skoulakis EMC, Linse S, Caughey B, Vendruscolo M
• Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α-Synuclein at Physiological pH with Sodium Salts.
  ACS chemical neuroscience 2023 Horne RI, Metrick MA, Man W, Rinauro DJ, Brotzakis ZF, Chia S, Meisl G, Vendruscolo M
• Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration.
  Acta neuropathologica communications 2023 Koga S, Metrick MA, Golbe LI, Santambrogio A, Kim M, Soto-Beasley AI, Walton RL, Baker MC, De Castro CF, DeTure M, Russell D, Navia BA, Sandiego C, Ross OA, Vendruscolo M, Caughey B, Dickson DW
• Computational maturation of a single-domain antibody against Aβ42 aggregation.
  Chemical science 2021 Lin J, Figazzolo C, Metrick MA, Sormanni P, Vendruscolo M
• Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear.
  Scientific reports 2021 Ferreira NC, Charco JM, Plagenz J, Orru CD, Denkers ND, Metrick MA, Hughson AG, Griffin KA, Race B, Hoover EA, Castilla J, Nichols TA, Miller MW, Caughey B
• Correction to: 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.
  Acta neuropathologica 2020 Saijo E, Metrick MA, Koga S, Parchi P, Litvan I, Spina S, Boxer A, Rojas JC, Galasko D, Kraus A, Rossi M, Newell K, Zanusso G, Grinberg LT, Seeley WW, Ghetti B, Dickson DW, Caughey B
• Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Metrick MA, do Carmo Ferreira N, Saijo E, Hughson AG, Kraus A, Orrú C, Miller MW, Zanusso G, Ghetti B, Vendruscolo M, Caughey B
• Ultrasensitive RT-QuIC Seed Amplification Assays for Disease-Associated Tau, α-Synuclein, and Prion Aggregates.
  Methods in molecular biology (Clifton, N.J.) 2019 Saijo E, Groveman BR, Kraus A, Metrick M, Orrù CD, Hughson AG, Caughey B
• Hofmeister Ion-Induced Changes in Water Structure Correlate with Changes in Solvation of an Aggregated Protein Complex.
  Langmuir : the ACS journal of surfaces and colloids 2016 Light TP, Corbett KM, Metrick MA, MacDonald G
• Variable-Field Analytical Ultracentrifugation: I. Time-Optimized Sedimentation Equilibrium.
  Biophysical journal 2015 Ma J, Metrick M, Ghirlando R, Zhao H, Schuck P
• Hofmeister ion effects on the solvation and thermal stability of model proteins lysozyme and myoglobin
  Colloids and Surfaces A 2015 Michael Metrick Gina MacDonald
• The effects of buffers and pH on the thermal stability, unfolding and substrate binding of RecA.
  Biophysical chemistry 2013 Metrick MA, Temple JE, MacDonald G