Michael Matthay, MD
Recall Faculty
Medicine
School of Medicine

Dr. Matthay's overall focus is on improving clinical care of patients with acute respiratory failure from the acute respiratory distress syndrome and from sepsis. His research and clinical trials groups are very well funded by grants from the National Institute of Health. He also spends considerable time mentoring physicians and young faculty in career development and academic medicine.

Awards

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• Lifetime Achievements in Research, Cell Therapy Trauma & Critical Care Society, 2022
• SMART award for Innovative Research, Critical Care Society, Milan, Italy, 2019
• Resident Molecular Medicine Mentor of the Year, UCSF, 2016

Education & Training

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• Fellowship Cardiovascular Research Institute University of California, San Francisco 1979
• Fellowship Pulmonary DIvision University of California, San Francisco 1978
• Internship and Residency Internal Medicine University of Colorado Medical Center 1976
• M.D. School of Medicine University of Pennsylvania 1973
• A.B. English Harvard University 1969

Websites

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• START Website (stemcellsards.ucsf.edu)
• Clinical Profile at UCSF Medical Center (ucsfhealth.org)

Videos

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• FDA Provides Guidance to Identify Gaps in Development Plan (youtube.com)

Grants and Projects

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• 1/1: Arrest Respiratory Failure Due to Pneumonia (Arrest Pneumonia), NIH, 2019-2024
• Prevention and Early Treatment of Acute Lung Injury, NIH, 2014-2021
• 1/1: Arrest Respiratory Failure Due to Pneumonia (Arrest Pneumonia), NIH, 2019-2020
• Allogeneic Human Mesenchymal Stem Cells for the Treatment of Acute Lung Injury, NIH, 2011-2018
• Resolution of Clinical Lung Injury, NIH, 1996-2018
• Title: Long-Term Oxygen Treatment Trial (LOTT) - Data Coordinating Center, NIH, 2011-2015
• Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
• Mucosal Immune Barrier in Infection and Immunity, NIH, 2002-2014
• Lung Fluid Balance and Mesenchymal Stem Cells, NIH, 1994-2014
• ARDS - SAILS Protocol, NIH, 2005-2013
• Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome, NIH, 2005-2013
• ARDS - SAILS Protocol, NIH/NHLBI, 2005-2012
• Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome, NIH/NHLBI, 2005-2012
• ARDS - ALTA Protocol, NIH/NHLBI, 2005-2012
• Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome, NIH, 2005-2012
• ARDS - EDEN Protocol, NIH, 2005-2012
• Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome, NIH, 2005-2011
• Transfusion and Lung Injury, NIH, 2005-2011
• SCCOR in translational research in Acute Lung Injury, NIH, 2003-2010
• Resolution of Clinical Lung Injury, NIH, 1996-2006
• Cctg Clinical Network for Ards Treatment--Critical Care, NIH/NHLBI, 1994-2001
• Pathophysiology of Lung Liquid &Protein Exchange, NIH, 1980-1994
• Alveolar Epithelial Liquid and Protein Clearance, NIH, 1988-1989

Publications (984)

Top publication keywords:
Pulmonary EdemaAdrenergic beta-AgonistsAcute Lung InjuryRespiratory InsufficiencyPulmonary AlveoliSepsisRespiratory MucosaRespiration, ArtificialBody FluidsLung InjuryPneumonia, BacterialMesenchymal Stem Cell TransplantationLungPneumonia, PneumococcalExtravascular Lung Water

• Longitudinal multi-omic signatures of ARDS and sepsis inflammatory phenotypes identify key pathways associated with mortality.
  medRxiv : the preprint server for health sciences 2025 Alipanah-Lechner N, Neyton L, Sinha P, Leroux C, Bardillon K, Carrillo SA, Chak S, Chao O, Hariharan T, Henrickson C, Kangelaris K, Langelier CR, Lee D, Lin C, Liu K, Magee L, Ringor A, Sarma A, …
• Reply to "Comment on 'A randomized trial of open lung protective ventilation compared to conventional mechanical ventilation in deceased organ donors'".
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2025 Ware LB, Koyama T, Shaver CM, Matthay MA
• Clonal expansion of alveolar fibroblast progeny drives pulmonary fibrosis in mouse models.
  The Journal of clinical investigation 2025 Molina C, Tsukui T, Khan IS, Ren X, Qiu W, Matthay M, Wolters P, Sheppard D
• Myeloid-mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis.
  The Journal of clinical investigation 2025 Yadav P, Gómez Ortega J, Dabral P, Tamaki W, Chien C, Chang KC, Biswas N, Pan S, Nilsson J, Yin X, Bhattacharyya A, Boostanpour K, Jujaray T, Wang JT, Tsukui T, Molina CJ, Auyeung VC, Sheppard D, Li B…
• Mechanisms of lung crosstalk with end organs: scientific session V-ReSPIRE 2025.
  American journal of physiology. Lung cellular and molecular physiology 2025 Singh N, Koçana C, Schmidt EP, Hepokoski ML, Matthay MA, Stevens T

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• Heterogeneity in association of myocardial injury and mortality in sepsis or acute respiratory distress syndrome by subphenotype: a retrospective study.
  Critical care (London, England) 2025 Sanchez PA, Obeidalla S, Kerchberger VE, Moore AR, Maddali MV, Kangelaris KN, Hendrickson CM, Evrard B, Liu KD, Bastarache JA, Matthay MA, Rogers AJ, Calfee CS
• Host-Microbe Multiomic Profiling Predicts Mortality in Sepsis.
  American journal of respiratory and critical care medicine 2025 Spottiswoode N, Neyton LP, Mick E, Kalantar KL, Hao S, Lydon EC, Narendra R, Serpa PH, Caldera S, Gomez A, Hendrickson C, Kangelaris K, Liu KD, Sinha P, DeRisi JL, Matthay MA, Calfee CS, Langelier CR
• Biologic Mechanisms Underlying the Heterogeneous Response to Tight Glycemic Control among Differentially Inflamed Patients in the HALF-PINT Trial.
  American journal of respiratory and critical care medicine 2025 Zinter MS, Taylor CS, Markovic D, Pellegrini M, Wong K, Balliu B, Gala KP, Asaro LA, Nadkarni VM, McQuillen PS, Vangala SS, Sinha P, Matthay MA, Agus MSD, Sapru A
• Treatment with Allogenic Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome: A Double-Blind, Placebo-controlled, Multi-Center, Phase 2b Clinical Trial (STAT).
  American journal of respiratory and critical care medicine 2025 Matthay MA, Zhou H, Sarma A, Alipanah-Lechner N, Hendrickson C, Kornblith LZ, Schreiber M, Zonies D, Khan A, Robinson B, Johnson NJ, Ware LB, Guillamondegui O, Casey J, Moore L, Patel B, Kao L, Wade …
• Approaches for Establishing Trust and Alleviating Stress During the Surrogate Informed Consent Process for Critical Care Research.
  Chest 2025 Tietbohl CK, Glaros C, Torres KA, Mantelli RA, Files DC, Mart MF, Matthay MA, Burns KEA, Matlock DD, Wynia M, Moss M
• The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2.
  bioRxiv : the preprint server for biology 2025 Suryawanshi RK, Jaishankar P, Correy GJ, Rachman MM, O'Leary PC, Taha TY, Matsui Y, Zapatero-Belinchón FJ, McCavitt-Malvido M, Doruk YU, Stevens MGV, Diolaiti ME, Jogalekar MP, Chen H, Richards AL, …
• Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis.
  bioRxiv : the preprint server for biology 2025 Yadav P, Gómez Ortega J, Dabral P, Tamaki W, Chien C, Chang KC, Biswas N, Pan S, Nilsson J, Yin X, Bhattacharyya A, Boostanpour K, Jujaray T, Wang J, Tsukui T, Molina C, Auyeung V, Sheppard D, Li B, …
• The lectin-like domain of TNF reduces pneumonia-induced injury in the perfused human lung.
  JCI insight 2025 Maishan M, Taenaka H, Evrard B, Matsumoto S, Ringor A, Leroux C, Lucas R, Matthay MA
• The Performance of the Surrogate Informed Consent Process for Critical Care Research: A Multi-Modal Study of Investigators, Coordinators, Surrogates, and Patients.
  Chest 2025 Glaros C, Tietbohl CK, Torres KA, Avallone Mantelli R, Files DC, Mart MF, Matthay MA, Burns KEA, Matlock DD, Wynia M, Moss M
• Clonal Expansion of Alveolar Fibroblast Progeny Drives Pulmonary Fibrosis.
  bioRxiv : the preprint server for biology 2025 Molina C, Tsukui T, Khan I, Ren X, Qiu W, Matthay M, Wolters P, Sheppard D
• Plasma Soluble Intercellular Adhesion Molecule-1 Has a Central Role in Biomarker Network Analysis and Is Associated With Poor Outcomes in Two Distinct Pediatric Cohorts of Acute Respiratory Distress Syndrome and Acute Respiratory Failure.
  Critical care medicine 2025 Lim MJ, Whitney JE, Sallee CJ, Markovic D, Bera A, Sinha P, Zeigler A, Chen L, Zinter MS, Ali A, Matthay MA, Schwingshackl A, Agus MSD, Sapru A, Pediatric Acute Lung Injury (PALI) and Coagulation and …
• Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2025 Zalucky AA, Dianti J, Neyton LPA, Sinha P, Liu KD, Matthay MA, Thompson BT, Goligher EC, Calfee CS
• Minimalistic Transcriptomic Signatures Permit Accurate Early Prediction of COVID-19 Mortality.
  medRxiv : the preprint server for health sciences 2025 Narendra R, Lydon EC, Van Phan H, Spottiswoode N, Neyton LP, Diray-Arce J, IMPACC Network, COMET Consortium, EARLI Consortium, Becker PM, Kim-Schulze S, Hoch A, Pickering H, van Zalm P, Cairns CB, …
• Awake Prone Positioning in COVID-19-Is There a New Standard of Care?
  JAMA internal medicine 2025 Matthay MA, Wick KD, Alipanah-Lechner N
• Beyond immunosuppression: decoding systemic immune dysregulation in ICU-acquired pneumonia.
  The European respiratory journal 2025 Neyton LPA, Matthay MA, Dela Cruz CS, Rizzo AN
• A randomized trial of open lung protective ventilation compared to conventional mechanical ventilation in deceased organ donors.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2025 Ware LB, Koyama T, Shaver CM, Swain S, Nguyen J, Salehi A, Dhillon G, Wickersham N, Maheshwari J, Singer JP, Weigt SS, Kukreja J, Matthay MA
• Endothelial ENaC-α Restrains Oxidative Stress in Lung Capillaries in Murine Pneumococcal Pneumonia-associated Acute Lung Injury.
  American journal of respiratory cell and molecular biology 2025 Romero MJ, Yue Q, Ahn WM, Hamacher J, Zaidi Y, Haigh S, Sridhar S, Gonzales J, Hudel M, Huo Y, Verin AD, Pace BS, Stansfield BK, Maishan M, Neptune ER, Enkhbaatar P, Su Y, Chakraborty T, Gonsalvez G, …
• Gut bacterial lactate stimulates lung epithelial mitochondria and exacerbates acute lung injury.
  bioRxiv : the preprint server for biology 2025 Upadhyay V, Ortega EF, Ramirez Hernandez LA, Alexander M, Kaur G, Trepka K, Rock RR, Shima RT, Cheshire WC, Alipanah-Lechner N, Calfee CS, Matthay MA, Lee JV, Goga A, Jain IH, Turnbaugh PJ
• Agreement between Sepsis-2 and Sepsis-3 Definitions among Patients Admitted to the Intensive Care Unit.
  Annals of the American Thoracic Society 2025 Zalucky AA, Evrard B, Delucchi K, Zhuo H, Wu N, Liu KD, Hendrickson CM, Matthay MA, Kangelaris KN, Calfee CS
• Temporal Transitions of the Hyperinflammatory and Hypoinflammatory Phenotypes in Critical Illness.
  American journal of respiratory and critical care medicine 2025 van Amstel RBE, Bartek B, Vlaar APJ, Gay E, van Vught LA, Cremer OL, Van der Poll T, Shapiro NI, Matthay MA, Calfee CS, Sinha P, Bos LDJ
• Unlocking the Therapeutic Code of Mesenchymal Stromal Cells.
  American journal of respiratory and critical care medicine 2025 Lingappan K, Matthay MA
• Acute respiratory distress vs healthy lung environments differently affect mesenchymal stromal cell extracellular vesicle miRNAs.
  Cytotherapy 2025 Rolandsson Enes S, Dzneladze I, Hampton TH, Neff SL, Asarian L, Barua J, Tertel T, Giebel B, Pereyra N, McKenna DH, Hu P, Acton E, Ashare A, Liu KD, Krasnodembskaya AD, English K, Stanton BA, Rocco …
• Anti-CD14 treatment in patients with severe COVID-19: Clinical and biological effects in a Phase 2 randomized open-label adaptive platform clinical trial.
  CHEST critical care 2024 Mabrey FL, Martin TR, Calfee CS, Liu KD, LaCombe B, Brown-Swigart L, Discacciati A, Eklund M, Heckbert SR, Matthay MA, Esserman L, Wurfel MM
• Pneumothoraces Associated With Vaping Cannabis Concentrate.
  Pediatrics 2024 Olgin GK, Ludwig C, Matthay MA, Gribben V
• Delphi-driven consensus definition for mesenchymal stromal cells and clinical reporting guidelines for mesenchymal stromal cell-based therapeutics.
  Cytotherapy 2024 Renesme L, Cobey KD, Lalu MM, Bubela T, Chinnadurai R, De Vos J, Dunbar R, Fergusson D, Freund D, Galipeau J, Horwitz E, Lê M, Matthay M, Moher D, Nolta J, Parker G, Phinney DG, Rao M, Rasko JEJ, …
• Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia.
  Nature communications 2024 Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC, COMET …
• Acute respiratory distress syndrome.
  BMJ (Clinical research ed.) 2024 Wick KD, Ware LB, Matthay MA
• Biomarkers of Acute Respiratory Distress Syndrome: Current State and Future Prospects.
  Clinics in chest medicine 2024 Zalucky AA, Matthay MA, Ware LB
• Definitions of Acute Respiratory Distress Syndrome: Present Recommendations and Challenges.
  Clinics in chest medicine 2024 Jayasimhan D, Matthay MA
• Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial.
  JAMA 2024 Ware LB, Files DC, Fowler A, Aboodi MS, Aggarwal NR, Brower RG, Chang SY, Douglas IS, Fields S, Foulkes AS, Ginde AA, Harris ES, Hendey GW, Hite RD, Huang W, Lai P, Liu KD, Thompson BT, Matthay MA, …
• Immediate myeloid depot for SARS-CoV-2 in the human lung.
  Science advances 2024 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, …
• Longitudinal importance of the soluble receptor for advanced glycation end-products in nonintubated hospitalized patients with COVID-19 pneumonia.
  American journal of physiology. Lung cellular and molecular physiology 2024 Wick KD, Siegel L, Oldmixon C, Lundgren JD, Thompson BT, Jones C, Leroux C, Matthay MA, ACTIV-3/TICO Study Group
• Use of modified Berlin criteria in identifying patients with acute respiratory distress syndrome: a single-centre retrospective cohort study.
  British journal of anaesthesia 2024 Thompson JH, Reddy K, Matthay MA, McAuley DF, Simpson AJ, Rostron AJ
• Long-term air pollution exposure and the risk of primary graft dysfunction after lung transplantation.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2024 Koyama T, Zhao Z, Balmes JR, Calfee CS, Matthay MA, Reilly JP, Porteous MK, Diamond JM, Christie JD, Cantu E, Ware LB, Lung Transplant Outcomes Group
• A fibroblast-dependent TGF-β1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis.
  The Journal of clinical investigation 2024 Cohen ML, Brumwell AN, Ho TC, Garakani K, Montas G, Leong D, Ding VW, Golden JA, Trinh BN, Jablons DM, Matthay MA, Jones KD, Wolters PJ, Wei Y, Chapman HA, Le Saux CJ
• 11β hydroxysteroid dehydrogenase type 1 transgenic mesenchymal stem cells attenuate inflammation in models of sepsis.
  Frontiers in bioengineering and biotechnology 2024 Mahida RY, Yuan Z, Kolluri KK, Scott A, Parekh D, Hardy RS, Matthay MA, Perkins GD, Janes SM, Thickett DR
• NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.
  Scientific reports 2024 Simoneau CR, Chen PY, Xing GK, Hayashi JM, Chen IP, Khalid MM, Meyers NL, Taha TY, Leon KE, Suryawanshi RK, McCavitt-Malvido M, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, …
• Vagal-α7 nicotinic acetylcholine receptor signaling exacerbates influenza severity by promoting lung epithelial cell infection.
  Journal of medical virology 2024 Zhao C, Pan M, Chen J, Li L, Zhang Y, Liu W, Matthay MA, Wang H, Jin X, Xu JF, Su X
• Incidence of acute kidney injury and attributive mortality in acute respiratory distress syndrome randomized trials.
  Intensive care medicine 2024 Antonucci E, Garcia B, Chen D, Matthay MA, Liu KD, Legrand M
• Biological effects of corticosteroids on pneumococcal pneumonia in Mice-translational significance.
  Critical care (London, England) 2024 Taenaka H, Wick KD, Sarma A, Matsumoto S, Ghale R, Fang X, Maishan M, Gotts JE, Langelier CR, Calfee CS, Matthay MA
• Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study.
  The Lancet. Microbe 2024 Jensen TO, Murray TA, Grandits GA, Jain MK, Grund B, Shaw-Saliba K, Matthay MA, Abassi M, Ardelt M, Baker JV, Chen P, Dewar RL, Goodman AL, Hatlen TJ, Highbarger HC, Holodniy M, Lallemand P, Laverdure…
• Neutrophil reduction attenuates the severity of lung injury in the early phase of pneumococcal pneumonia in mice.
  American journal of physiology. Lung cellular and molecular physiology 2024 Taenaka H, Fang X, Maishan M, Trivedi A, Wick KD, Gotts JE, Martin TR, Calfee CS, Matthay MA
• Elevated Hemoglobin A1c and the Risk of Developing ARDS in Two Cohort Studies.
  CHEST critical care 2024 Bogart AM, Lopez CR, Obeidalla SN, Wang C, Willmore A, Jauregui A, Kangelaris KN, Hendrickson C, Gomez A, Liu KD, Matthay MA, Shaver CM, Bastarache JA, Calfee CS, Kerchberger VE, Ware LB
• Reply to Liufu et al. and to Palanidurai et al.
  American journal of respiratory and critical care medicine 2024 Matthay MA, Ware LB, Riviello ED, Wick KD, Thompson T, Martin TR
• Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis.
  Critical care (London, England) 2024 Evrard B, Sinha P, Delucchi K, Hendrickson CM, Kangelaris KN, Liu KD, Willmore A, Wu N, Neyton L, Schmiege E, Gomez A, Kerchberger VE, Zalucky A, Matthay MA, Ware LB, Calfee CS
• Life-saving effect of pulmonary surfactant in premature babies.
  The Journal of clinical investigation 2024 Raj JU, Bland RD, Bhattacharya J, Rabinovitch M, Matthay MA
• Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome.
  Critical care (London, England) 2024 Baedorf-Kassis E, Murn M, Dzierba AL, Serra AL, Garcia I, Minus E, Padilla C, Sarge T, Goodspeed VM, Matthay MA, Gong MN, Cook D, Loring SH, Talmor D, Beitler JR, EPVent-2 Study Group
• Rapidly improving ARDS differs clinically and biologically from persistent ARDS.
  Critical care (London, England) 2024 Valda Toro PL, Willmore A, Wu NE, Delucchi KL, Jauregui A, Sinha P, Liu KD, Hendrickson CM, Sarma A, Neyton LPA, Leligdowicz A, Langelier CR, Zhuo H, Jones C, Kangelaris KN, Gomez AD, Matthay MA, …
• The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia.
  American journal of respiratory and critical care medicine 2024 Chouchane O, Schuurman AR, Reijnders TDY, Peters-Sengers H, Butler JM, Uhel F, Schultz MJ, Bonten MJ, Cremer OL, Calfee CS, Matthay MA, Langley RJ, Alipanah-Lechner N, Kingsmore SF, Rogers A, van …
• Timing of antibiotic treatment identifies distinct clinical presentations among patients presenting with suspected septic shock.
  Journal of the American College of Emergency Physicians open 2024 Prasad PA, Esmaili AM, Oreper S, Beagle AJ, Hubbard C, Raffel KE, Abe-Jones Y, Fang MC, Liu KD, Matthay MA, Kangelaris KN
• Cell-based Therapies for Acute Respiratory Distress Syndrome: Where Are We Now?
  American journal of respiratory and critical care medicine 2024 Curley GF, O'Kane CM, McAuley DF, Matthay MA, Laffey JG
• Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes.
  American journal of respiratory and critical care medicine 2024 Neyton LPA, Sinha P, Sarma A, Mick E, Kalantar K, Chen S, Wu N, Delucchi K, Zhuo H, Bos LDJ, Jauregui A, Gomez A, Hendrickson CM, Kangelaris KN, Leligdowicz A, Liu KD, Matthay MA, Langelier CR, Calfee…
• Molecular Phenotypes of Acute Respiratory Distress Syndrome in the ROSE Trial Have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally over Time.
  American journal of respiratory and critical care medicine 2024 Sinha P, Neyton L, Sarma A, Wu N, Jones C, Zhuo H, Liu KD, Sanchez Guerrero E, Ghale R, Love C, Mick E, Delucchi KL, Langelier CR, Thompson BT, Matthay MA, Calfee CS
• Inter- and Intra-donor variability in bone marrow-derived mesenchymal stromal cells: implications for clinical applications.
  Cytotherapy 2024 Trivedi A, Lin M, Miyazawa B, Nair A, Vivona L, Fang X, Bieback K, Schäfer R, Spohn G, McKenna D, Zhuo H, Matthay MA, Pati S
• Effect of Neutralizing Monoclonal Antibody Treatment on Early Trajectories of Virologic and Immunologic Biomarkers in Patients Hospitalized With COVID-19.
  The Journal of infectious diseases 2024 Jensen TO, Grandits GA, Jain MK, Murray TA, Grund B, Shaw-Saliba K, Matthay MA, Abassi M, Ardelt M, Baker JV, Chen P, Dewar RL, Goodman AL, Hatlen TJ, Highbarger HC, Holodniy M, Lallemand P, Laverdure…
• The Translational Value of Rodent Models of Sepsis.
  American journal of respiratory and critical care medicine 2024 Matthay MA, Schmidt EP, Bastarache JA, Calfee CS, Frevert CW, Martin TR
• Biological Effects of Corticosteroids on Pneumococcal Pneumonia in Mice and Humans.
  Research square 2024 Taenaka H, Wick KD, Sarma A, Matsumoto S, Ghale R, Fang X, Maishan M, Gotts JE, Langelier CR, Calfee CS, Matthay MA
• Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial.
  Critical care (London, England) 2024 Alipanah-Lechner N, Hurst-Hopf J, Delucchi K, Swigart L, Willmore A, LaCombe B, Dewar R, Lane HC, Lallemand P, Liu KD, Esserman L, Matthay MA, Calfee CS, I-SPY COVID Consortium
• Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS).
  Thorax 2024 Mehta P, Samanta RJ, Wick K, Coll RC, Mawhinney T, McAleavey PG, Boyle AJ, Conlon J, Shankar-Hari M, Rogers A, Calfee CS, Matthay MA, Summers C, Chambers RC, McAuley DF, O'Kane CM
• The antibiotic resistance reservoir of the lung microbiome expands with age in a population of critically ill patients.
  Nature communications 2024 Chu VT, Tsitsiklis A, Mick E, Ambroggio L, Kalantar KL, Glascock A, Osborne CM, Wagner BD, Matthay MA, DeRisi JL, Calfee CS, Mourani PM, Langelier CR
• A New Global Definition of Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2024 Matthay MA, Arabi Y, Arroliga AC, Bernard G, Bersten AD, Brochard LJ, Calfee CS, Combes A, Daniel BM, Ferguson ND, Gong MN, Gotts JE, Herridge MS, Laffey JG, Liu KD, Machado FR, Martin TR, McAuley DF,…
• Unraveling the enigma of genetics and phenotypes in ARDS.
  Intensive care medicine 2023 Artigas A, Barbas CSV, Matthay MA
• In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response.
  Science advances 2023 Chen X, Haribowo AG, Baik AH, Fossati A, Stevenson E, Chen YR, Reyes NS, Peng T, Matthay MA, Traglia M, Pico AR, Jarosz DF, Buchwalter A, Ghaemmaghami S, Swaney DL, Jain IH
• Corticosteroids in adults with acute respiratory distress syndrome and severe pneumonia.
  BJA education 2023 Jayasimhan D, Matthay MA
• Evidence for lung barrier regeneration by differentiation prior to binucleated and stem cell division.
  The Journal of cell biology 2023 Guild J, Juul NH, Andalon A, Taenaka H, Coffey RJ, Matthay MA, Desai TJ
• MicroRNA-1 protects the endothelium in acute lung injury.
  JCI insight 2023 Korde A, Haslip M, Pednekar P, Khan A, Chioccioli M, Mehta S, Lopez-Giraldez F, Bermejo S, Rojas M, Dela Cruz C, Matthay MA, Pober JS, Pierce RW, Takyar SS
• The antibiotic resistance reservoir of the lung microbiome expands with age.
  Research square 2023 Chu VT, Tsitsiklis A, Mick E, Ambroggio L, Kalantar KL, Glascock A, Osborne CM, Wagner BD, Matthay MA, DeRisi JL, Calfee CS, Mourani PM, Langelier CR
• Elevated Plasma Interleukin-18 Identifies High-Risk Acute Respiratory Distress Syndrome Patients not Distinguished by Prior Latent Class Analyses Using Traditional Inflammatory Cytokines: A Retrospective Analysis of Two Randomized Clinical Trials.
  Critical care medicine 2023 Moore AR, Pienkos SM, Sinha P, Guan J, O'Kane CM, Levitt JE, Wilson JG, Shankar-Hari M, Matthay MA, Calfee CS, Baron RM, McAuley DF, Rogers AJ
• Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials.
  The Lancet. Respiratory medicine 2023 Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, …
• Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis.
  Intensive care medicine 2023 Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Jones TK, Anderson BJ, Ittner CA, Dunn T, Miano TA, Oniyide O, Balmes JR, Matthay MA, Calfee CS, Christie JD, Meyer NJ, Ware LB
• Clinical and biological heterogeneity of multisystem inflammatory syndrome in adults following SARS-CoV-2 infection: a case series.
  Frontiers in medicine 2023 Barth KE, Spottiswoode N, Hurabielle C, Subbaraj L, COMET Consortium, Calfee CS, Matthay MA, French S, Connolly A, Hewitt SM, Vannella KM, Barnett C, Langelier CR, Patterson S
• Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial.
  The Lancet. Respiratory medicine 2023 Brown SM, Barkauskas CE, Grund B, Sharma S, Phillips AN, Leither L, Peltan ID, Lanspa M, Gilstrap DL, Mourad A, Lane K, Beitler JR, Serra AL, Garcia I, Almasri E, Fayed M, Hubel K, Harris ES, …
• ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.
  Intensive care medicine 2023 Grasselli G, Calfee CS, Camporota L, Poole D, Amato MBP, Antonelli M, Arabi YM, Baroncelli F, Beitler JR, Bellani G, Bellingan G, Blackwood B, Bos LDJ, Brochard L, Brodie D, Burns KEA, Combes A, D'…
• Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis.
  Critical care (London, England) 2023 Rosenberger CM, Wick KD, Zhuo H, Wu N, Chen Y, Kapadia SB, Guimaraes A, Chang D, Choy DF, Chen H, Peck M, Sullivan KM, Ke S, Jauregui A, Leligdowicz A, Sinha P, Gomez AD, Kangelaris KN, Delucchi K, …
• Should We Add Fludrocortisone to Hydrocortisone for Treatment of Septic Shock?
  JAMA internal medicine 2023 Matthay MA, Dahabreh IJ, Thompson BT
• Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS.
  Frontiers in immunology 2023 Mahida RY, Lax S, Bassford CR, Scott A, Parekh D, Hardy RS, Naidu B, Matthay MA, Stewart PM, Cooper MC, Perkins GD, Thickett DR
• Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials.
  American journal of respiratory and critical care medicine 2023 Zinter MS, Markovic D, Asaro LA, Nadkarni VM, McQuillen PS, Sinha P, Matthay MA, Jeschke MG, Agus MSD, Sapru A, CAF-PINT Investigators of the PALISI Network
• Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials.
  Critical care (London, England) 2023 Pienkos SM, Moore AR, Guan J, Levitt JE, Matthay MA, Baron RM, Conlon J, McAuley DF, O'Kane CM, Rogers AJ
• Association of SARS-CoV-2 nucleocapsid viral antigen and the receptor for advanced glycation end products with development of severe disease in patients presenting to the emergency department with COVID-19.
  Frontiers in immunology 2023 Matthay ZA, Fields AT, Wick KD, Jones C, Lane HC, Herrera K, Nuñez-Garcia B, Gennatas E, Hendrickson CM, Kornblith AE, Matthay MA, Kornblith LZ, COVID-19 Associated Coagulopathy Inflammation …
• Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection.
  Frontiers in immunology 2023 Maishan M, Sarma A, Chun LF, Caldera S, Fang X, Abbott J, Christenson SA, Langelier CR, Calfee CS, Gotts JE, Matthay MA
• Effects of the circulating environment of COVID-19 on platelet and neutrophil behavior.
  Frontiers in immunology 2023 Fields AT, Andraska EA, Kaltenmeier C, Matthay ZA, Herrera K, Nuñez-Garcia B, Jones CM, Wick KD, Liu S, Luo JH, Yu YP, Matthay MA, Hendrickson CM, Bainton RJ, Barrett TJ, Berger JS, Neal MD, Kornblith…
• Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes.
  Molecular cell 2023 Baik AH, Haribowo AG, Chen X, Queliconi BB, Barrios AM, Garg A, Maishan M, Campos AR, Matthay MA, Jain IH
• SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.
  Stem cell reports 2023 Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, …
• Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir.
  Immunity 2023 Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB, Peng T
• Are circulating endothelial cells the next target for transcriptome-level pathway analysis in ARDS?
  American journal of physiology. Lung cellular and molecular physiology 2023 Costa Monteiro AC, Matthay MA
• Myeloid Extracellular Vesicles: New Players in Indirect Lung Injury.
  American journal of respiratory cell and molecular biology 2023 Mahida RY, Matthay MA
• Understanding the Role of Mesenchymal Stromal Cells in Treating COVID-19 Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2023 O'Kane CM, Matthay MA
• Mechanisms of impaired alveolar fluid clearance.
  Anatomical record (Hoboken, N.J. : 2007) 2023 Taenaka H, Matthay MA
• Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS.
  American journal of physiology. Lung cellular and molecular physiology 2023 Alipanah-Lechner N, Neyton L, Mick E, Willmore A, Leligdowicz A, Contrepois K, Jauregui A, Zhuo H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Matthay MA, Rogers AJ, Calfee CS
• Lessons From a Negative Clinical Trial: Novel Immunological Targets for COVID-19 and Beyond.
  Critical care medicine 2022 Sullivan KM, Matthay MA
• Chest x-ray imaging score is associated with severity of COVID-19 pneumonia: the MBrixia score.
  Scientific reports 2022 Jensen CM, Costa JC, Nørgaard JC, Zucco AG, Neesgaard B, Niemann CU, Ostrowski SR, Reekie J, Holten B, Kalhauge A, Matthay MA, Lundgren JD, Helleberg M, Moestrup KS
• Association Between Shared Decision-Making During Family Meetings and Surrogates' Trust in Their ICU Physician.
  Chest 2022 Lincoln TE, Buddadhumaruk P, Arnold RM, Scheunemann LP, Ernecoff NC, Chang CH, Carson SS, Hough CL, Curtis JR, Anderson W, Steingrub J, Peterson MW, Lo B, Matthay MA, White DB
• Reply to Khatun et al.
  American journal of respiratory and critical care medicine 2022 Joffre J, Matthay MA, Hellman J
• Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults.
  Nature microbiology 2022 Kalantar KL, Neyton L, Abdelghany M, Mick E, Jauregui A, Caldera S, Serpa PH, Ghale R, Albright J, Sarma A, Tsitsiklis A, Leligdowicz A, Christenson SA, Liu K, Kangelaris KN, Hendrickson C, Sinha P, …
• COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective.
  American journal of respiratory and critical care medicine 2022 Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COVID…
• Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.
  Science (New York, N.Y.) 2022 Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T
• The prognostic value of early measures of the ventilatory ratio in the ARDS ROSE trial.
  Critical care (London, England) 2022 Monteiro ACC, Vangala S, Wick KD, Delucchi KL, Siegel ER, Thompson BT, Liu KD, Sapru A, Sinha P, Matthay MA, NHLBI PETAL Network
• Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19.
  Critical care (London, England) 2022 Wick KD, Leligdowicz A, Willmore A, Carrillo SA, Ghale R, Jauregui A, Chak SS, Nguyen V, Lee D, Jones C, Dewar R, Lane HC, Kangelaris KN, Hendrickson CM, Liu KD, Sinha P, Erle DJ, Langelier CR, …
• New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021.
  American journal of respiratory cell and molecular biology 2022 Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, Calfee CS, Desai TJ, Herold S, Hough CL, Looney MR, Matthay MA, Meyer N, Parikh SM, Stevens T, Thompson BT
• Opportunities for improved clinical trial designs in acute respiratory distress syndrome.
  The Lancet. Respiratory medicine 2022 Wick KD, Aggarwal NR, Curley MAQ, Fowler AA, Jaber S, Kostrubiec M, Lassau N, Laterre PF, Lebreton G, Levitt JE, Mebazaa A, Rubin E, Sinha P, Ware LB, Matthay MA
• The Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19.
  Annals of internal medicine 2022 ACTIV-3/TICO Study Group, Rogers AJ, Wentworth D, Phillips A, Shaw-Saliba K, Dewar RL, Aggarwal NR, Babiker AG, Chang W, Dharan NJ, Davey VJ, Higgs ES, Gerry N, Ginde AA, Hayanga JWA, Highbarger H, …
• Pulse oximetry for the diagnosis and management of acute respiratory distress syndrome.
  The Lancet. Respiratory medicine 2022 Wick KD, Matthay MA, Ware LB
• Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 : A Randomized Controlled Trial.
  Annals of internal medicine 2022 ACTIV-3/TICO Study Group, Barkauskas C, Mylonakis E, Poulakou G, Young BE, Vock DM, Siegel L, Engen N, Grandits G, Mosaly NR, Vekstein AM, Rogers R, Shehadeh F, Kaczynski M, Mylona EK, Syrigos KN, …
• NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.
  bioRxiv : the preprint server for biology 2022 Simoneau CR, Chen PY, Xing GK, Khalid MM, Meyers NL, Hayashi JM, Taha TY, Leon KE, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose J, Matthay…
• Upcoming and urgent challenges in critical care research based on COVID-19 pandemic experience.
  Anaesthesia, critical care & pain medicine 2022 Verdonk F, Feyaerts D, Badenes R, Bastarache JA, Bouglé A, Ely W, Gaudilliere B, Howard C, Kotfis K, Lautrette A, Le Dorze M, Mankidy BJ, Matthay MA, Morgan CK, Mazeraud A, Patel BV, Pattnaik R, …
• Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19.
  The Lancet. Respiratory medicine 2022 Casey JD, Beskow LM, Brown J, Brown SM, Gayat É, Ng Gong M, Harhay MO, Jaber S, Jentzer JC, Laterre PF, Marshall JC, Matthay MA, Rice TW, Rosenberg Y, Turnbull AE, Ware LB, Self WH, Mebazaa A, Collins…
• Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells.
  American journal of physiology. Lung cellular and molecular physiology 2022 Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA
• I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations.
  BMJ open 2022 Files DC, Matthay MA, Calfee CS, Aggarwal NR, Asare AL, Beitler JR, Berger PA, Burnham EL, Cimino G, Coleman MH, Crippa A, Discacciati A, Gandotra S, Gibbs KW, Henderson PT, Ittner CAG, Jauregui A, …
• Ventilatory Ratio Is a Valuable Prognostic Indicator in an Observational Cohort of Patients With ARDS.
  Respiratory care 2022 Siegel ER, Zhuo H, Sinha P, Papolos AI, Ni SA, Vessel K, Belzer A, Minus EB, Calfee CS, Matthay MA, Wick KD
• Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury.
  Journal of thrombosis and haemostasis : JTH 2022 Matthay ZA, Fields AT, Nunez-Garcia B, Park JJ, Jones C, Leligdowicz A, Hendrickson CM, Callcut RA, Matthay MA, Kornblith LZ
• Proceedings of the ISCT scientific signature series symposium, "Advances in cell and gene therapies for lung diseases and critical illnesses": International Society for Cell & Gene Therapy, Burlington VT, US, July 16, 2021.
  Cytotherapy 2022 Ting AE, Baker EK, Champagne J, Desai TJ, Dos Santos CC, Heijink IH, Itescu S, Le Blanc K, Matthay MA, McAuley DF, McIntyre L, Mei SHJ, Parekkadan B, Rocco PRM, Sheridan J, Thébaud B, Weiss DJ
• Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination.
  Nature 2022 Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Gascon R, Tsou CL, Garcia-Knight MA, Sotomayor-Gonzalez A, …
• Immediate myeloid depot for SARS-CoV-2 in the human lung.
  Research square 2022 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, …
• Mesenchymal Stromal Cell Extracellular Vesicles: A New Approach for Preventing Bronchopulmonary Dysplasia?
  American journal of respiratory and critical care medicine 2022 Klinger JR, Matthay MA
• Immediate myeloid depot for SARS-CoV-2 in the human lung.
  bioRxiv : the preprint server for biology 2022 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, …
• RAGE has potential pathogenetic and prognostic value in nonintubated hospitalized patients with COVID-19.
  JCI insight 2022 Wick KD, Siegel L, Neaton JD, Oldmixon C, Lundgren J, Dewar RL, Lane HC, Thompson BT, Matthay MA, ACTIV-3/TICO study group
• Extracorporeal Membrane Oxygenation for Respiratory Failure Related to COVID-19: A Nationwide Cohort Study.
  Anesthesiology 2022 Nesseler N, Fadel G, Mansour A, Para M, Falcoz PE, Mongardon N, Porto A, Bertier A, Levy B, Cadoz C, Guinot PG, Fouquet O, Fellahi JL, Ouattara A, Guihaire J, Ruggieri VG, Gaudard P, Labaste F, …
• Transfusion-related Acute Lung Injury: 36 Years of Progress (1985-2021).
  Annals of the American Thoracic Society 2022 Toy P, Looney MR, Popovsky M, Palfi M, Berlin G, Chapman CE, Bolton-Maggs P, Matthay MA
• Cigarette Smoke Exposure and Acute Respiratory Distress Syndrome in Sepsis: Epidemiology, Clinical Features, and Biologic Markers.
  American journal of respiratory and critical care medicine 2022 Moazed F, Hendrickson C, Jauregui A, Gotts J, Conroy A, Delucchi K, Zhuo H, Arambulo M, Vessel K, Ke S, Deiss T, Ni A, Leligdowicz A, Abbott J, Cohen MJ, Sinha P, Gomez A, Kangelaris K, Kornblith L, …
• Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages.
  American journal of physiology. Lung cellular and molecular physiology 2022 Matsumoto S, Traber MG, Leonard SW, Choi J, Fang X, Maishan M, Wick KD, Jones KD, Calfee CS, Gotts JE, Matthay MA
• Pulmonary microbiome and gene expression signatures differentiate lung function in pediatric hematopoietic cell transplant candidates.
  Science translational medicine 2022 Zinter MS, Versluys AB, Lindemans CA, Mayday MY, Reyes G, Sunshine S, Chan M, Fiorino EK, Cancio M, Prevaes S, Sirota M, Matthay MA, Kharbanda S, Dvorak CC, Boelens JJ, DeRisi JL
• CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome.
  American journal of physiology. Lung cellular and molecular physiology 2022 Mahida RY, Price J, Lugg ST, Li H, Parekh D, Scott A, Harrison P, Matthay MA, Thickett DR
• Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness.
  Critical care medicine 2022 Mikacenic C, Bhatraju P, Robinson-Cohen C, Kosamo S, Fohner AE, Dmyterko V, Long SA, Cerosaletti K, Calfee CS, Matthay MA, Walley KR, Russell JA, Christie JD, Meyer NJ, Christiani DC, Wurfel MM
• A decoy mutant ACE2 designed to reduce COVID-19.
  Trends in pharmacological sciences 2022 Maishan M, Lim DL, Zimmerman GA, Matthay MA
• Limited Cross-Variant Immunity after Infection with the SARS-CoV-2 Omicron Variant Without Vaccination.
  medRxiv : the preprint server for health sciences 2022 Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, …
• Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.
  American journal of respiratory cell and molecular biology 2022 Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy …
• Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance in Early Human Sepsis.
  Shock (Augusta, Ga.) 2022 Leligdowicz A, Kamm J, Kalantar K, Jauregui A, Vessel K, Caldera S, Serpa PH, Abbott J, Fang X, Tian X, Prakash A, Kangelaris KN, Liu KD, Calfee CS, Langelier C, Matthay MA
• Functional Outcomes and Morbidity in Pediatric Sepsis Survivors: A Tanzanian Experience.
  Frontiers in pediatrics 2022 Lau-Braunhut SA, Smith AM, Steurer MA, Murray BL, Sawe H, Matthay MA, Reynolds T, Kortz TB
• Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.
  The Lancet. Respiratory medicine 2022 Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz …
• Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges.
  Intensive care medicine experimental 2021 Masterson CH, Ceccato A, Artigas A, Dos Santos C, Rocco PR, Rolandsson Enes S, Weiss DJ, McAuley D, Matthay MA, English K, Curley GF, Laffey JG
• Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.
  Nature cell biology 2021 Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T
• Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial.
  Annals of internal medicine 2021 ACTIV-3/TICO Bamlanivimab Study Group, Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower …
• Cell Therapy with the Cell or without the Cell for Premature Infants?: Time Will Tell.
  American journal of respiratory and critical care medicine 2021 Thébaud B, Matthay MA
• Carbonic Anhydrase IX: Scaring Away the Grim Reaper in Acute Lung Injury?
  American journal of respiratory cell and molecular biology 2021 Leligdowicz A, Matthay MA
• Delayed Presentation and Mortality in Children With Sepsis in a Public Tertiary Care Hospital in Tanzania.
  Frontiers in pediatrics 2021 Smith AM, Sawe HR, Matthay MA, Murray BL, Reynolds T, Kortz TB
• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
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• Promises and challenges of personalized medicine to guide ARDS therapy.
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• Molecular programs of fibrotic change in aging human lung.
  Nature communications 2021 Lee S, Islam MN, Boostanpour K, Aran D, Jin G, Christenson S, Matthay MA, Eckalbar WL, DePianto DJ, Arron JR, Magee L, Bhattacharya S, Matsumoto R, Kubota M, Farber DL, Bhattacharya J, Wolters PJ, …
• Delayed angiopoietin-2 blockade reduces influenza-induced lung injury and improves survival in mice.
  Physiological reports 2021 Gotts JE, Maishan M, Chun L, Fang X, Han CY, Chiueh V, Khakoo AY, Lee T, Stolina M, Matthay MA
• Beyond the Alveolar Epithelium: Plasma Soluble Receptor for Advanced Glycation End Products Is Associated With Oxygenation Impairment, Mortality, and Extrapulmonary Organ Failure in Children With Acute Respiratory Distress Syndrome.
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• Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells.
  The European respiratory journal 2021 Rolandsson Enes S, Hampton TH, Barua J, McKenna DH, Dos Santos CC, Amiel E, Ashare A, Liu KD, Krasnodembskaya AD, English K, Stanton BA, Rocco PRM, Matthay MA, Weiss DJ
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• Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome.
  Frontiers in medicine 2021 Mahida RY, Scott A, Parekh D, Lugg ST, Belchamber KBR, Hardy RS, Matthay MA, Naidu B, Thickett DR
• Therapeutic effects of high molecular weight hyaluronic acid in severe Pseudomonas aeruginosa pneumonia in ex vivo perfused human lungs.
  American journal of physiology. Lung cellular and molecular physiology 2021 Zhang X, Sugita S, Liu A, Naito Y, Hwang W, Qiu H, Sakamoto A, Sawa T, Matthay MA, Lee JW
• Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis.
  The European respiratory journal 2021 Mahida RY, Scott A, Parekh D, Lugg ST, Hardy RS, Lavery GG, Matthay MA, Naidu B, Perkins GD, Thickett DR
• Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.
  Nature communications 2021 Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, …
• IL-6 Receptor Antagonist Therapy for Patients Hospitalized for COVID-19: Who, When, and How?
  JAMA 2021 Matthay MA, Luetkemeyer AF
• Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
  The New England journal of medicine 2021 ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, …
• Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial.
  Critical care (London, England) 2021 Monteiro ACC, Flori H, Dahmer MK, Sim MS, Quasney MW, Curley MAQ, Matthay MA, Sapru A, BALI Study Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Networ
• Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19.
  Nature 2021 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Plasma Metabolites in Early Sepsis Identify Distinct Clusters Defined by Plasma Lipids.
  Critical care explorations 2021 Rogers AJ, Leligdowicz A, Contrepois K, Jauregui A, Vessel K, Deiss TJ, Belzer A, Liu T, Lippi M, Ke S, Ross E, Zhou H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Calfee CS, Matthay MA
• Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study.
  Thorax 2021 Sinha P, Delucchi KL, Chen Y, Zhuo H, Abbott J, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB…
• Vitamin D Status and Clinical Outcomes in Acute Respiratory Distress Syndrome: A Secondary Analysis From the Assessment of Low Tidal Volume and Elevated End-Expiratory Volume to Obviate Lung Injury (ALVEOLI) Trial.
  Journal of intensive care medicine 2021 Quraishi SA, Bhan I, Matthay MA, Thompson BT, Camargo CA, Bajwa EK
• Mesenchymal stromal cells reduce evidence of lung injury in patients with ARDS.
  JCI insight 2021 Wick KD, Leligdowicz A, Zhuo H, Ware LB, Matthay MA
• Readmission following both cardiac and non-cardiac acute dyspnoea is associated with a striking risk of death.
  ESC heart failure 2021 Cerlinskaite K, Mebazaa A, Cinotti R, Matthay M, Wussler DN, Gayat E, Juknevicius V, Kozhuharov N, Dinort J, Michou E, Gualandro DM, Paleviciute E, Alitoit-Marrote I, Kablucko D, Bagdonaite L, …
• SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.
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• Associations of D-Dimer on Admission and Clinical Features of COVID-19 Patients: A Systematic Review, Meta-Analysis, and Meta-Regression.
  Frontiers in immunology 2021 Zhao R, Su Z, Komissarov AA, Liu SL, Yi G, Idell S, Matthay MA, Ji HL
• The Berlin definition of acute respiratory distress syndrome: should patients receiving high-flow nasal oxygen be included?
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• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
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• Transepithelial nasal potential difference in patients with, and at risk of acute respiratory distress syndrome.
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• Molecular markers of telomere dysfunction and senescence are common findings in the usual interstitial pneumonia pattern of lung fibrosis.
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• Inhibition of the lipoxin A4 and resolvin D1 receptor impairs host response to acute lung injury caused by pneumococcal pneumonia in mice.
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• The ARREST Pneumonia Clinical Trial. Rationale and Design.
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• The pulmonary metatranscriptome prior to pediatric HCT identifies post-HCT lung injury.
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• Fibrinolytic niche is required for alveolar type 2 cell-mediated alveologenesis via a uPA-A6-CD44+-ENaC signal cascade.
  Signal transduction and targeted therapy 2021 Ali G, Zhang M, Zhao R, Jain KG, Chang J, Komatsu S, Zhou B, Liang J, Matthay MA, Ji HL
• Global absence and targeting of protective immune states in severe COVID-19.
  Nature 2021 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.
  Research square 2021 Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, …
• The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness.
  The Journal of clinical investigation 2021 Reilly JP, Meyer NJ, Shashaty MG, Anderson BJ, Ittner C, Dunn TG, Lim B, Forker C, Bonk MP, Kotloff E, Feng R, Cantu E, Mangalmurti NS, Calfee CS, Matthay MA, Mikacenic C, Walley KR, Russell J, …
• A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.
  American journal of physiology. Lung cellular and molecular physiology 2020 Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell C, Matthay MA
• A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19.
  The New England journal of medicine 2020 ACTIV-3/TICO LY-CoV555 Study Group, Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower BG,…
• Biological Mechanisms of COVID-19 Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2020 Matthay MA, Leligdowicz A, Liu KD
• Corticosteroids, COVID-19 pneumonia, and acute respiratory distress syndrome.
  The Journal of clinical investigation 2020 Matthay MA, Wick KD
• Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate.
  American journal of respiratory cell and molecular biology 2020 Matsumoto S, Fang X, Traber MG, Jones KD, Langelier C, Hayakawa Serpa P, Calfee CS, Matthay MA, Gotts JE
• Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial.
  JAMA 2020 Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, Chang SY, Collins SP, Eppensteiner JC, Filbin MR, Files DC, Gibbs KW, Ginde AA, Gong MN, Harrell FE, Hayden DL, Hough CL, Johnson NJ, …
• Alternative Tobacco Product Use in Critically Ill Patients.
  International journal of environmental research and public health 2020 Liu T, Deiss TJ, Lippi MW, Jauregui A, Vessel K, Ke S, Belzer A, Zhuo H, Kangelaris KN, Gomez AD, Matthay MA, Liu KD, Calfee CS
• Phenotypes and personalized medicine in the acute respiratory distress syndrome.
  Intensive care medicine 2020 Matthay MA, Arabi YM, Siegel ER, Ware LB, Bos LDJ, Sinha P, Beitler JR, Wick KD, Curley MAQ, Constantin JM, Levitt JE, Calfee CS
• Designing an ARDS trial for 2020 and beyond: focus on enrichment strategies.
  Intensive care medicine 2020 Ware LB, Matthay MA, Mebazaa A
• Dexamethasone in hospitalised patients with COVID-19: addressing uncertainties.
  The Lancet. Respiratory medicine 2020 Matthay MA, Thompson BT
• Global Absence and Targeting of Protective Immune States in Severe COVID-19.
  bioRxiv : the preprint server for biology 2020 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Global Absence and Targeting of Protective Immune States in Severe COVID-19.
  Research square 2020 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.
  Nature cell biology 2020 Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T
• Using best subset regression to identify clinical characteristics and biomarkers associated with sepsis-associated acute kidney injury.
  American journal of physiology. Renal physiology 2020 Kwong YD, Mehta KM, Miaskowski C, Zhuo H, Yee K, Jauregui A, Ke S, Deiss T, Abbott J, Kangelaris KN, Sinha P, Hendrickson C, Gomez A, Leligdowicz A, Matthay MA, Calfee CS, Liu KD
• Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation.
  PloS one 2020 Wilfong EM, Croze R, Fang X, Schwede M, Niemi E, López GY, Lee JW, Nakamura MC, Matthay MA
• The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung.
  Intensive care medicine experimental 2020 Leligdowicz A, Ross JT, Nesseler N, Matthay MA
• Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Iatrogenic Anemia.
  American journal of respiratory and critical care medicine 2020 Baron RM, Christman JW, Liu KD, Matthay MA, Self WH, McVerry BJ, Hite RD, Paine R, Wurfel MM, Shapiro NI, Adams PW, Schmidt EP, Ringwood N
• Insufficient hyperfibrinolysis in COVID-19: a systematic review of thrombolysis based on meta-analysis and meta-regression.
  medRxiv : the preprint server for health sciences 2020 Ji HJ, Su Z, Zhao R, Komissarov AA, Yi G, Liu SL, Idell S, Matthay MA
• Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells.
  American journal of physiology. Lung cellular and molecular physiology 2020 Abreu SC, Hampton TH, Hoffman E, Dearborn J, Ashare A, Singh Sidhu K, Matthews DE, McKenna DH, Amiel E, Barua J, Krasnodembskaya A, English K, Mahon B, Dos Santos C, Cruz FF, Chambers DC, Liu KD, …
• NT-proBNP levels in the identification and classification of pulmonary transfusion reactions.
  Transfusion 2020 Roubinian NH, Chowdhury D, Hendrickson JE, Triulzi DJ, Gottschall JL, Looney MR, Matthay MA, Kor DJ, Brambilla D, Kleinman SH, Murphy EL, NHLBI Recipient Epidemiology and Donor Evaluation Study-III (…
• Is a "Cytokine Storm" Relevant to COVID-19?
  JAMA internal medicine 2020 Sinha P, Matthay MA, Calfee CS
• Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care. NHLBI Working Group Report.
  American journal of respiratory and critical care medicine 2020 Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, …
• Need for Additional Trials of Vitamin C for Sepsis.
  JAMA 2020 Files DC, Liu KD, Matthay M
• Association of patient weight status with plasma surfactant protein D, a biomarker of alveolar epithelial injury, in children with acute respiratory failure.
  Pediatric pulmonology 2020 Ward SL, Dahmer MK, Weeks HM, Sapru A, Quasney MW, Curley MAQ, Liu KD, Matthay MA, Flori HR
• Combined Mesenchymal Stromal Cell Therapy and Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome. A Randomized Controlled Trial in Sheep.
  American journal of respiratory and critical care medicine 2020 Millar JE, Bartnikowski N, Passmore MR, Obonyo NG, Malfertheiner MV, von Bahr V, Redd MA, See Hoe L, Ki KK, Pedersen S, Boyle AJ, Baillie JK, Shekar K, Palpant N, Suen JY, Matthay MA, McAuley DF, …
• Higher plasma cystatin C is associated with mortality after acute respiratory distress syndrome: findings from a Fluid and Catheter Treatment Trial (FACTT) substudy.
  Critical care (London, England) 2020 Hendrickson CM, Kwong YD, Belzer AG, Shlipak MG, Matthay MA, Liu KD
• Extracellular Vesicles: A New Frontier for Research in Acute Respiratory Distress Syndrome.
  American journal of respiratory cell and molecular biology 2020 Mahida RY, Matsumoto S, Matthay MA
• The ex vivo perfused human lung is resistant to injury by high-dose S. pneumoniae bacteremia.
  American journal of physiology. Lung cellular and molecular physiology 2020 Ross JT, Nesseler N, Leligdowicz A, Zemans RL, Mahida RY, Minus E, Langelier C, Gotts JE, Matthay MA
• Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time.
  Critical care medicine 2020 Schwede M, Lee RY, Zhuo H, Kangelaris KN, Jauregui A, Vessel K, Belzer A, Deiss T, Matthay MA, Liu KD, Calfee CS
• Impact of Bilateral Infiltrates on Inflammatory Biomarker Levels and Clinical Outcomes of Children With Oxygenation Defect.
  Critical care medicine 2020 Kohne JG, Dahmer MK, Weeks HM, Kaciroti N, Quasney MW, Sapru A, Curley MAQ, Matthay M, Flori H
• Plasmin improves blood-gas barrier function in oedematous lungs by cleaving epithelial sodium channels.
  British journal of pharmacology 2020 Zhao R, Ali G, Nie HG, Chang Y, Bhattarai D, Su X, Zhao X, Matthay MA, Ji HL
• Patterns and Trends in Advance Care Planning Among Older Adults Who Received Intensive Care at the End of Life.
  JAMA internal medicine 2020 Block BL, Jeon SY, Sudore RL, Matthay MA, Boscardin WJ, Smith AK
• The potential of lipid mediator networks as ocular surface therapeutics and biomarkers.
  The ocular surface 2020 Flitter BA, Fang X, Matthay MA, Gronert K
• Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis.
  Nature communications 2020 Tsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, Adams TS, Schupp JC, Poli SD, Rosas IO, Kaminski N, Matthay MA, Wolters PJ, Sheppard D
• Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure.
  Chest 2020 Dahmer MK, Flori H, Sapru A, Kohne J, Weeks HM, Curley MAQ, Matthay MA, Quasney MW, BALI and RESTORE Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALIS
• Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis.
  Respiratory research 2020 Carla A, Pereira B, Boukail H, Audard J, Pinol-Domenech N, De Carvalho M, Blondonnet R, Zhai R, Morand D, Lambert C, Sapin V, Ware LB, Calfee CS, Bastarache JA, Laffey JG, Juffermans NP, Bos LD, …
• Gender Differences in Authorship of Critical Care Literature.
  American journal of respiratory and critical care medicine 2020 Vranas KC, Ouyang D, Lin AL, Slatore CG, Sullivan DR, Kerlin MP, Liu KD, Baron RM, Calfee CS, Ware LB, Halpern SD, Matthay MA, Herridge MS, Mehta S, Rogers AJ
• Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility.
  Physiological reviews 2020 Ji HL, Zhao R, Matalon S, Matthay MA
• Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis.
  Intensive care medicine 2020 Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, Kangelaris KN, Gomez A, Hendrickson C, Liu KD, Matthay MA, Ware LB, Calfee CS
• Treatment for severe acute respiratory distress syndrome from COVID-19.
  The Lancet. Respiratory medicine 2020 Matthay MA, Aldrich JM, Gotts JE
• Improved survival after lung transplantation for adults requiring preoperative invasive mechanical ventilation: A national cohort study.
  The Journal of thoracic and cardiovascular surgery 2020 Hamilton BCS, Dincheva GR, Matthay MA, Hays S, Singer JP, Brzezinski M, Kukreja J
• Potential Value of Biomarker Signatures in Sepsis and Acute Respiratory Distress Syndrome in Children and Adults.
  Critical care medicine 2020 Hendrickson CM, Matthay MA
• Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop.
  Intensive care medicine 2020 Harhay MO, Casey JD, Clement M, Collins SP, Gayat É, Gong MN, Jaber S, Laterre PF, Marshall JC, Matthay MA, Monroe RE, Rice TW, Rubin E, Self WH, Mebazaa A
• Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment.
  Critical care medicine 2020 Prasad PA, Fang MC, Abe-Jones Y, Calfee CS, Matthay MA, Kangelaris KN
• Peripheral blood leukocyte telomere length is associated with survival of sepsis patients.
  The European respiratory journal 2020 Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ
• Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials.
  The Lancet. Respiratory medicine 2020 Sinha P, Delucchi KL, McAuley DF, O'Kane CM, Matthay MA, Calfee CS
• Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2020 Jones TK, Feng R, Kerchberger VE, Reilly JP, Anderson BJ, Shashaty MGS, Wang F, Dunn TG, Riley TR, Abbott J, Ittner CAG, Christiani DC, Mikacenic C, Wurfel MM, Ware LB, Calfee CS, Matthay MA, Christie…
• The authors reply.
  Critical care medicine 2020 Rogers AJ, Desai M, Matthay MA, Choi AM, Baron RM
• Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study.
  Critical care (London, England) 2019 Anderson BJ, Calfee CS, Liu KD, Reilly JP, Kangelaris KN, Shashaty MGS, Lazaar AL, Bayliffe AI, Gallop RJ, Miano TA, Dunn TG, Johansson E, Abbott J, Jauregui A, Deiss T, Vessel K, Belzer A, Zhuo H, …
• The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury.
  PloS one 2019 Kwong YD, Chen S, Bouajram R, Li F, Matthay MA, Mehta KM, Glidden DV, Liu KD
• Therapeutic Effects of Hyaluronic Acid in Bacterial Pneumonia in Ex Vivo Perfused Human Lungs.
  American journal of respiratory and critical care medicine 2019 Liu A, Park JH, Zhang X, Sugita S, Naito Y, Lee JH, Kato H, Hao Q, Matthay MA, Lee JW
• Proliferative regulation of alveolar epithelial type 2 progenitor cells by human Scnn1d gene.
  Theranostics 2019 Zhao R, Ali G, Chang J, Komatsu S, Tsukasaki Y, Nie HG, Chang Y, Zhang M, Liu Y, Jain K, Jung BG, Samten B, Jiang D, Liang J, Ikebe M, Matthay MA, Ji HL
• Lung inflammatory environments differentially alter mesenchymal stromal cell behavior.
  American journal of physiology. Lung cellular and molecular physiology 2019 Abreu SC, Rolandsson Enes S, Dearborn J, Goodwin M, Coffey A, Borg ZD, Dos Santos CC, Wargo MJ, Cruz FF, Loi R, DeSarno M, Ashikaga T, Antunes MA, Rocco PRM, Liu KD, Lee JW, Matthay MA, McKenna DH, …
• Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice.
  American journal of physiology. Lung cellular and molecular physiology 2019 Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA
• Plasma total fibroblast growth factor 23 levels are associated with acute kidney injury and mortality in children with acute respiratory distress syndrome.
  PloS one 2019 Hanudel MR, Zinter MS, Chen L, Gala K, Lim M, Guglielmo M, Deshmukh T, Vangala S, Matthay M, Sapru A
• A Multicenter Study of the Causes and Consequences of Optimistic Expectations About Prognosis by Surrogate Decision-Makers in ICUs.
  Critical care medicine 2019 White DB, Carson S, Anderson W, Steingrub J, Bird G, Curtis JR, Matthay M, Peterson M, Buddadhumaruk P, Shields AM, Ernecoff N, Shotsberger K, Weissfeld L, Chang CH, Pike F, Lo B, Hough CL
• Association of Elevated Plasma Interleukin-18 Level With Increased Mortality in a Clinical Trial of Statin Treatment for Acute Respiratory Distress Syndrome.
  Critical care medicine 2019 Rogers AJ, Guan J, Trtchounian A, Hunninghake GM, Kaimal R, Desai M, Kozikowski LA, DeSouza L, Mogan S, Liu KD, Matthay MA, Steingrub J, Wheeler A, Yoon JH, Nakahira K, Choi AM, Baron RM
• The Continued Need for Clinical Trials in Deceased Organ Donor Management.
  Transplantation 2019 Niemann CU, Matthay MA, Ware LB
• The ex vivo human lung: research value for translational science.
  JCI insight 2019 Ross JT, Nesseler N, Lee JW, Ware LB, Matthay MA
• Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction.
  Respiratory care 2019 Papolos AI, Schiller NB, Belzer A, Zhuo H, Gotts JE, Bibby D, Calfee CS, Matthay MA
• Pathogenesis of Acute Respiratory Distress Syndrome.
  Seminars in respiratory and critical care medicine 2019 Huppert LA, Matthay MA, Ware LB
• Clinician-Family Communication About Patients' Values and Preferences in Intensive Care Units.
  JAMA internal medicine 2019 Scheunemann LP, Ernecoff NC, Buddadhumaruk P, Carson SS, Hough CL, Curtis JR, Anderson WG, Steingrub J, Lo B, Matthay M, Arnold RM, White DB
• Is a Part Better than the Whole for Cell-based Therapy for Acute Respiratory Distress Syndrome?
  Anesthesiology 2019 Lee JW, Matthay MA
• A prospective investigation of interleukin-8 levels in pediatric acute respiratory failure and acute respiratory distress syndrome.
  Critical care (London, England) 2019 Flori H, Sapru A, Quasney MW, Gildengorin G, Curley MAQ, Matthay MA, Dahmer MK, BALI and RESTORE Study Investigators, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI)
• Could Decisions to Limit Treatment Contribute to Mortality Differences between Patients with Different Presepsis Trajectories?
  Annals of the American Thoracic Society 2019 Block BL, Matthay M
• Identification of Acute Kidney Injury Subphenotypes with Differing Molecular Signatures and Responses to Vasopressin Therapy.
  American journal of respiratory and critical care medicine 2019 Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, …
• Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2019 Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A
• Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply.
  The Lancet. Respiratory medicine 2019 Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS
• The authors reply.
  Critical care medicine 2019 Fielding-Singh V, Matthay MA, Calfee CS
• The authors reply.
  Critical care medicine 2019 Fielding-Singh V, Matthay MA, Calfee CS
• Acute respiratory distress syndrome.
  Nature reviews. Disease primers 2019 Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG, Calfee CS
• Heterogeneity in sepsis: new biological evidence with clinical applications.
  Critical care (London, England) 2019 Leligdowicz A, Matthay MA
• AIMing Immunomodulation Therapy at Sepsis.
  American journal of respiratory cell and molecular biology 2019 Leligdowicz A, Matthay MA
• Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure.
  Annals of the American Thoracic Society 2019 Lanspa MJ, Gong MN, Schoenfeld DA, Lee KT, Grissom CK, Hou PC, Serpa-Neto A, Brown SM, Iwashyna TJ, Yealy DM, Hough CL, Brower RG, Calfee CS, Hyzy RC, Matthay MA, Miller RR, Steingrub JS, Thompson BT,…
• Physiologic Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2019 Sinha P, Calfee CS, Beitler JR, Soni N, Ho K, Matthay MA, Kallet RH
• Early Plasma Matrix Metalloproteinase Profiles. A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2019 Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A
• ECMO in severe acute respiratory distress syndrome.
  The Lancet. Respiratory medicine 2019 Matthay MA
• Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma.
  American journal of respiratory and critical care medicine 2019 Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Christie JD, Lanken PN, Wang C, Balmes JR, Matthay MA, Calfee CS, Ware LB
• Variability in Pediatric Ideal Body Weight Calculation: Implications for Lung-Protective Mechanical Ventilation Strategies in Pediatric Acute Respiratory Distress Syndrome.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2018 Ward SL, Quinn CM, Steurer MA, Liu KD, Flori HR, Matthay MA
• Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, …
• Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial.
  The Lancet. Respiratory medicine 2018 Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, …
• Beyond Low Tidal Volume Ventilation: Treatment Adjuncts for Severe Respiratory Failure in Acute Respiratory Distress Syndrome.
  Critical care medicine 2018 Fielding-Singh V, Matthay MA, Calfee CS
• Therapeutic potential of mesenchymal stromal cells in the treatment of ARDS.
  Transfusion 2018 Huppert LA, Liu KD, Matthay MA
• Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis.
  Intensive care medicine 2018 Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, …
• Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study.
  Intensive care medicine 2018 Sinha P, Delucchi KL, Thompson BT, McAuley DF, Matthay MA, Calfee CS, NHLBI ARDS Network
• Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2018 Dahmer MK, Quasney MW, Sapru A, Gildengorin G, Curley MAQ, Matthay MA, Flori H, BALI and RESTORE Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALIS
• Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome.
  The New England journal of medicine 2018 Mi MY, Matthay MA, Morris AH
• Assessment of industry data on pulmonary and immunosuppressive effects of IQOS.
  Tobacco control 2018 Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J
• Possible hepatotoxicity of IQOS.
  Tobacco control 2018 Chun L, Moazed F, Matthay M, Calfee C, Gotts J
• Meta-Analysis of Preclinical Studies of Fibrinolytic Therapy for Acute Lung Injury.
  Frontiers in immunology 2018 Liu C, Ma Y, Su Z, Zhao R, Zhao X, Nie HG, Xu P, Zhu L, Zhang M, Li X, Zhang X, Matthay MA, Ji HL
• Therapeutic effects of human mesenchymal stem cell microvesicles in an ex vivo perfused human lung injured with severe E. coli pneumonia.
  Thorax 2018 Park J, Kim S, Lim H, Liu A, Hu S, Lee J, Zhuo H, Hao Q, Matthay MA, Lee JW
• Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.
  The Lancet. Respiratory medicine 2018 Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF, Irish Critical Care Trials Group
• Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome.
  Canadian journal of kidney health and disease 2018 Hsu RK, Truwit JD, Matthay MA, Levitt JE, Thompson BT, Liu KD
• Effects of bone marrow-derived mesenchymal stromal cells on gene expression in human alveolar type II cells exposed to TNF-α, IL-1β, and IFN-γ.
  Physiological reports 2018 Schwede M, Wilfong EM, Zemans RL, Lee PJ, Dos Santos C, Fang X, Matthay MA
• Pulmonary mechanics and gas exchange characteristics in uncommon etiologies of acute respiratory distress syndrome.
  Journal of thoracic disease 2018 Kallet RH, Ho K, Lipnick MS, Matthay MA
• Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.
  Intensive care medicine 2018 Jabaudon M, Blondonnet R, Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, …
• Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis.
  American journal of physiology. Lung cellular and molecular physiology 2018 Leligdowicz A, Chun LF, Jauregui A, Vessel K, Liu KD, Calfee CS, Matthay MA
• Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.
  The Journal of clinical investigation 2018 Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T
• Influence of Clinical Factors and Exclusion Criteria on Mortality in ARDS Observational Studies and Randomized Controlled Trials.
  Respiratory care 2018 Pais FM, Sinha P, Liu KD, Matthay MA
• A psychometric study of the decisional conflict scale in surrogate decision makers.
  Patient education and counseling 2018 Pecanac KE, Brown RL, Steingrub J, Anderson W, Matthay MA, White DB
• Secondary peritonitis: principles of diagnosis and intervention.
  BMJ (Clinical research ed.) 2018 Ross JT, Matthay MA, Harris HW
• Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS.
  Thorax 2018 Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB
• Mesenchymal stromal cells and macrophages in sepsis: new insights.
  The European respiratory journal 2018 Kotas ME, Matthay MA
• Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload.
  Critical care medicine 2018 Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Michalkiewicz M, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL, National Heart, Lung, and Blood Institute (…
• Endothelial biomarkers in human sepsis: pathogenesis and prognosis for ARDS.
  Pulmonary circulation 2018 Hendrickson CM, Matthay MA
• Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.
  American journal of physiology. Lung cellular and molecular physiology 2018 Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA
• Inhibiting Bruton's tyrosine kinase rescues mice from lethal influenza-induced acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2018 Florence JM, Krupa A, Booshehri LM, Davis SA, Matthay MA, Kurdowska AK
• Assessing Preventable Harms in the Intensive Care Unit: Data From a Tertiary Care Academic Medical Institution.
  American journal of medical quality : the official journal of the American College of Medical Quality 2018 Sung N, Aldrich JM, Shimabukuro DW, Matthay MA, Liu KD
• Elevated donor plasminogen activator inhibitor-1 levels and the risk of primary graft dysfunction.
  Clinical transplantation 2018 Hamilton BCS, Dincheva GR, Zhuo H, Golden JA, Brzezinski M, Singer JP, Matthay MA, Kukreja J
• The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia.
  Stem cells (Dayton, Ohio) 2018 Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin JH
• Cell-based Therapy in Sepsis. A Step Closer.
  American journal of respiratory and critical care medicine 2018 Gotts JE, Matthay MA
• Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma.
  The journal of trauma and acute care surgery 2018 Potter DR, Miyazawa BY, Gibb SL, Deng X, Togaratti PP, Croze RH, Srivastava AK, Trivedi A, Matthay M, Holcomb JB, Schreiber MA, Pati S
• Exosome-based Therapy for Bronchopulmonary Dysplasia.
  American journal of respiratory and critical care medicine 2018 Matthay MA, Abman SH
• Measurement of Protein Permeability and Fluid Transport of Human Alveolar Epithelial Type II Cells Under Pathological Conditions.
  Methods in molecular biology (Clifton, N.J.) 2018 Fang X, Matthay MA
• Rectal and Bladder Temperatures vs Forehead Core Temperatures Measured With SpotOn Monitoring System.
  American journal of critical care : an official publication, American Association of Critical-Care Nurses 2018 Schell-Chaple HM, Liu KD, Matthay MA, Puntillo KA
• Clinical Presentation and Outcomes among Children with Sepsis Presenting to a Public Tertiary Hospital in Tanzania.
  Frontiers in pediatrics 2017 Kortz TB, Sawe HR, Murray B, Enanoria W, Matthay MA, Reynolds T
• The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations.
  American journal of respiratory cell and molecular biology 2017 Agrawal PB, Wang R, Li HL, Schmitz-Abe K, Simone-Roach C, Chen J, Shi J, Louie T, Sheng S, Towne MC, Brainson CF, Matthay MA, Kim CF, Bamshad M, Emond MJ, Gerard NP, Kleyman TR, Gerard C
• ENaCs as Both Effectors and Regulators of MiRNAs in Lung Epithelial Development and Regeneration.
  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017 Ding Y, Zhao R, Zhao X, Matthay MA, Nie HG, Ji HL
• Extracellular Vesicle Transfer from Mesenchymal Stromal Cells Modulates Macrophage Function in Acute Lung Injury. Basic Science and Clinical Implications.
  American journal of respiratory and critical care medicine 2017 Matthay MA
• Intratracheal instillation of alveolar type II cells enhances recovery from acute lung injury in rats.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2017 Guillamat-Prats R, Puig F, Camprubí-Rimblas M, Herrero R, Serrano-Mollar A, Gómez MN, Tijero J, Matthay MA, Blanch L, Artigas A
• Cytokine Profiles of Severe Influenza Virus-Related Complications in Children.
  Frontiers in immunology 2017 Fiore-Gartland A, Panoskaltsis-Mortari A, Agan AA, Mistry AJ, Thomas PG, Matthay MA, PALISI PICFlu Investigators, Hertz T, Randolph AG
• Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".
  American journal of physiology. Lung cellular and molecular physiology 2017 Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE
• Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.
  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2017 Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA
• Derivation and validation of a two-biomarker panel for diagnosis of ARDS in patients with severe traumatic injuries.
  Trauma surgery & acute care open 2017 Ware LB, Zhao Z, Koyama T, Brown RM, Semler MW, Janz DR, May AK, Fremont RD, Matthay MA, Cohen MJ, Calfee CS
• Fifty Years of Research in ARDS. Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value.
  American journal of respiratory and critical care medicine 2017 Laffey JG, Matthay MA
• Local lung hypoxia determines epithelial fate decisions during alveolar regeneration.
  Nature cell biology 2017 Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE
• Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction.
  Frontiers in immunology 2017 Czikora I, Alli AA, Sridhar S, Matthay MA, Pillich H, Hudel M, Berisha B, Gorshkov B, Romero MJ, Gonzales J, Wu G, Huo Y, Su Y, Verin AD, Fulton D, Chakraborty T, Eaton DC, Lucas R
• Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial.
  Critical care medicine 2017 Schell-Chaple HM, Liu KD, Matthay MA, Sessler DI, Puntillo KA
• Endothelial Damage During Septic Shock: Significance and Implications for Future Therapies.
  Chest 2017 Crouser ED, Matthay MA
• Inhalation therapies in acute respiratory distress syndrome.
  Annals of translational medicine 2017 Artigas A, Camprubí-Rimblas M, Tantinyà N, Bringué J, Guillamat-Prats R, Matthay MA
• Lung Injury Etiology and Other Factors Influencing the Relationship Between Dead-Space Fraction and Mortality in ARDS.
  Respiratory care 2017 Kallet RH, Zhuo H, Ho K, Lipnick MS, Gomez A, Matthay MA
• External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome.
  Intensive care medicine 2017 Zhao Z, Wickersham N, Kangelaris KN, May AK, Bernard GR, Matthay MA, Calfee CS, Koyama T, Ware LB
• Clinical trials in acute respiratory distress syndrome: challenges and opportunities.
  The Lancet. Respiratory medicine 2017 Matthay MA, McAuley DF, Ware LB
• Pulmonary toxicity of e-cigarettes.
  American journal of physiology. Lung cellular and molecular physiology 2017 Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE
• Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial.
  The Lancet. Respiratory medicine 2017 McAuley DF, Cross LM, Hamid U, Gardner E, Elborn JS, Cullen KM, Dushianthan A, Grocott MP, Matthay MA, O'Kane CM
• Erratum to: Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction - a randomised placebo-controlled trial (KARE): study protocol.
  Trials 2017 Cross LJM, O'Kane CM, McDowell C, Elborn JJ, Matthay MA, McAuley DF
• Understanding blood gas analysis.
  Intensive care medicine 2017 Gattinoni L, Pesenti A, Matthay M
• Differentiating pulmonary transfusion reactions using recipient and transfusion factors.
  Transfusion 2017 Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL, TRALI Study Group
• Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome.
  Critical care medicine 2017 Zinter MS, Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay MA, Sapru A
• Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome.
  Critical care medicine 2017 Festic E, Carr GE, Cartin-Ceba R, Hinds RF, Banner-Goodspeed V, Bansal V, Asuni AT, Talmor D, Rajagopalan G, Frank RD, Gajic O, Matthay MA, Levitt JE
• Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection.
  PloS one 2017 Leligdowicz A, Conroy AL, Hawkes M, Zhong K, Lebovic G, Matthay MA, Kain KC
• Signals of vagal circuits engaging with AKT1 in α7 nAChR+CD11b+ cells lessen E. coli and LPS-induced acute inflammatory injury.
  Cell discovery 2017 Zhao C, Yang X, Su EM, Huang Y, Li L, Matthay MA, Su X
• Alveolar Fluid Clearance in Pathologically Relevant Conditions: In Vitro and In Vivo Models of Acute Respiratory Distress Syndrome.
  Frontiers in immunology 2017 Huppert LA, Matthay MA
• Profiling of ARDS pulmonary edema fluid identifies a metabolically distinct subset.
  American journal of physiology. Lung cellular and molecular physiology 2017 Rogers AJ, Contrepois K, Wu M, Zheng M, Peltz G, Ware LB, Matthay MA
• Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days.
  American journal of physiology. Lung cellular and molecular physiology 2017 Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay MA, NHLBI ARDS Network
• Protein biomarkers associated with primary graft dysfunction following lung transplantation.
  American journal of physiology. Lung cellular and molecular physiology 2017 Hamilton BC, Kukreja J, Ware LB, Matthay MA
• Concise Review: Mesenchymal Stem (Stromal) Cells: Biology and Preclinical Evidence for Therapeutic Potential for Organ Dysfunction Following Trauma or Sepsis.
  Stem cells (Dayton, Ohio) 2017 Matthay MA, Pati S, Lee JW
• Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm.
  Vox sanguinis 2016 Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL, NHLBI Recipient Epidemiology and Donor Evaluation Study-III (…
• Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death.
  Critical care (London, England) 2016 Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM
• Clinical, Radiographic, Physiologic, and Biologic Measurements to Facilitate Personalized Medicine for ARDS.
  Chest 2016 Matthay MA, Beitler JR
• Overnight Extubation in Patients With Mechanical Ventilation: Is It Harmful?
  JAMA internal medicine 2016 Moore PK, Matthay MA
• What drives neutrophils to the alveoli in ARDS?
  Thorax 2016 Zemans RL, Matthay MA
• Cathepsin L Helps to Defend Mice from Infection with Influenza A.
  PloS one 2016 Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH
• Challenges in predicting which patients will develop ARDS.
  The Lancet. Respiratory medicine 2016 Matthay MA
• A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2016 Spicer AC, Calfee CS, Zinter MS, Khemani RG, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay MA, Sapru A
• Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2016 Ward SL, Quinn CM, Valentine SL, Sapru A, Curley MA, Willson DF, Liu KD, Matthay MA, Flori HR
• IL1RL1 asthma risk variants regulate airway type 2 inflammation.
  JCI insight 2016 Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, …
• Plasma Concentrations of Soluble Suppression of Tumorigenicity-2 and Interleukin-6 Are Predictive of Successful Liberation From Mechanical Ventilation in Patients With the Acute Respiratory Distress Syndrome.
  Critical care medicine 2016 Alladina JW, Levy SD, Hibbert KA, Januzzi JL, Harris RS, Matthay MA, Thompson BT, Bajwa EK, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network
• The authors reply.
  Critical care medicine 2016 Kangelaris KN, Ware LB, Matthay MA, Calfee CS
• The authors reply.
  Critical care medicine 2016 Kangelaris KN, Ware LB, Matthay MA, Calfee CS
• miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis.
  PloS one 2016 Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay MA, Kukreja J, Erle DJ, Collard HR, Wolters PJ
• Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria.
  Intensive care medicine 2016 Beitler JR, Sands SA, Loring SH, Owens RL, Malhotra A, Spragg RG, Matthay MA, Thompson BT, Talmor D
• A new experimental model of acid- and endotoxin-induced acute lung injury in rats.
  American journal of physiology. Lung cellular and molecular physiology 2016 Puig F, Herrero R, Guillamat-Prats R, Gómez MN, Tijero J, Chimenti L, Stelmakh O, Blanch L, Serrano-Mollar A, Matthay MA, Artigas A
• The acute respiratory distress syndrome following isolated severe traumatic brain injury.
  The journal of trauma and acute care surgery 2016 Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ
• Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.
  Critical care (London, England) 2016 Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA, NHLBI ARDS Network
• Sepsis: pathophysiology and clinical management.
  BMJ (Clinical research ed.) 2016 Gotts JE, Matthay MA
• Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2016 Ware LB, Zhao Z, Koyama T, May AK, Matthay MA, Lurmann FW, Balmes JR, Calfee CS
• Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS.
  Stem cells (Dayton, Ohio) 2016 Jackson MV, Morrison TJ, Doherty DF, McAuley DF, Matthay MA, Kissenpfennig A, O'Kane CM, Krasnodembskaya AD
• Negative-Pressure Pulmonary Edema.
  Chest 2016 Bhattacharya M, Kallet RH, Ware LB, Matthay MA
• Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation.
  Intensive care medicine 2016 Vieillard-Baron A, Matthay M, Teboul JL, Bein T, Schultz M, Magder S, Marini JJ
• Diagnostic workup for ARDS patients.
  Intensive care medicine 2016 Papazian L, Calfee CS, Chiumello D, Luyt CE, Meyer NJ, Sekiguchi H, Matthay MA, Meduri GU
• Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Chan MC, Kuok DI, Leung CY, Hui KP, Valkenburg SA, Lau EH, Nicholls JM, Fang X, Guan Y, Lee JW, Chan RW, Webster RG, Matthay MA, Peiris JS
• Key stakeholders' perceptions of the acceptability and usefulness of a tablet-based tool to improve communication and shared decision making in ICUs.
  Journal of critical care 2016 Ernecoff NC, Witteman HO, Chon K, Chen YI, Buddadhumaruk P, Chiarchiaro J, Shotsberger KJ, Shields AM, Myers BA, Hough CL, Carson SS, Lo B, Matthay MA, Anderson WG, Peterson MW, Steingrub JS, Arnold …
• Acute Hypoxemic Respiratory Failure after Large-Volume Thoracentesis. Mechanisms of Pleural Fluid Formation and Reexpansion Pulmonary Edema.
  Annals of the American Thoracic Society 2016 Walter JM, Matthay MA, Gillespie CT, Corbridge T
• New Strategies for Effective Therapeutics in Critically Ill Patients.
  JAMA 2016 Matthay MA, Liu KD
• Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation.
  Thorax 2016 Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS
• Acute cor pulmonale and the acute respiratory distress syndrome.
  Intensive care medicine 2016 Guérin C, Matthay MA
• Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome.
  Critical care medicine 2016 Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay MA, Calfee CS
• Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study.
  Critical care (London, England) 2015 Orwoll BE, Spicer AC, Zinter MS, Alkhouli MF, Khemani RG, Flori HR, Neuhaus JM, Calfee CS, Matthay MA, Sapru A
• Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality.
  American journal of physiology. Lung cellular and molecular physiology 2015 Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay MA, Sapru A
• Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome.
  Critical care medicine 2015 Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB
• Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice.
  American journal of respiratory and critical care medicine 2015 Monsel A, Zhu YG, Gennai S, Hao Q, Hu S, Rouby JJ, Rosenzwajg M, Matthay MA, Lee JW
• Resolution of Alveolar Edema in Acute Respiratory Distress Syndrome. Physiology and Biology.
  American journal of respiratory and critical care medicine 2015 Matthay MA, Ware LB
• Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Fang X, Abbott J, Cheng L, Colby JK, Lee JW, Levy BD, Matthay MA
• Visualization of Fra-1/AP-1 activation during LPS-induced inflammatory lung injury using fluorescence optical imaging.
  American journal of physiology. Lung cellular and molecular physiology 2015 Rajasekaran S, Tamatam CR, Potteti HR, Raman V, Lee JW, Matthay MA, Mehta D, Reddy NM, Reddy SP
• Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies.
  Chest 2015 Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA, Ware LB
• Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D
• Saving lives with high-flow nasal oxygen.
  The New England journal of medicine 2015 Matthay MA
• Sedation protocol for critically ill pediatric patients--reply.
  JAMA 2015 Curley MA, Wypij D, Matthay MA, RESTORE Study Investigators
• Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials.
  Critical care medicine 2015 Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A
• Microvesicles Derived From Human Mesenchymal Stem Cells Restore Alveolar Fluid Clearance in Human Lungs Rejected for Transplantation.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2015 Gennai S, Monsel A, Hao Q, Park J, Matthay MA, Lee JW
• Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome - authors' reply.
  The Lancet. Respiratory medicine 2015 Wilson J, McKenna D, Liu KD, Matthay MA
• Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.
  American journal of physiology. Lung cellular and molecular physiology 2015 Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS
• Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.
  Intensive care medicine 2015 Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA, NHLBI ARDS Network
• Therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome.
  Annals of the American Thoracic Society 2015 Matthay MA
• Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions.
  Transfusion 2015 Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL, TRALI Study Group
• Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.
  Intensive care medicine 2015 Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Abbot J, Matthay MA, NHLBI ARDS Network
• A multicenter study of key stakeholders' perspectives on communicating with surrogates about prognosis in intensive care units.
  Annals of the American Thoracic Society 2015 Anderson WG, Cimino JW, Ernecoff NC, Ungar A, Shotsberger KJ, Pollice LA, Buddadhumaruk P, Carson SS, Curtis JR, Hough CL, Lo B, Matthay MA, Peterson MW, Steingrub JS, White DB
• Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized clinical trial.
  JAMA 2015 Curley MA, Wypij D, Watson RS, Grant MJ, Asaro LA, Cheifetz IM, Dodson BL, Franck LS, Gedeit RG, Angus DC, Matthay MA, RESTORE Study Investigators and the Pediatric Acute Lung Injury and Sepsis …
• Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites.
  The Journal of biological chemistry 2015 Ji HL, Zhao R, Komissarov AA, Chang Y, Liu Y, Matthay MA
• Body temperature and mortality in patients with acute respiratory distress syndrome.
  American journal of critical care : an official publication, American Association of Critical-Care Nurses 2015 Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network
• Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury.
  Nature 2014 Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA
• Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial.
  The Lancet. Respiratory medicine 2014 Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA
• Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.
  Transfusion 2014 Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, …
• Biology and pathology of fibroproliferation following the acute respiratory distress syndrome.
  Intensive care medicine 2014 Hendrickson CM, Crestani B, Matthay MA
• Biomarkers to exclude the diagnosis of ventilator-associated pneumonia.
  Thorax 2014 Matthay MA
• Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis.
  The Lancet. Respiratory medicine 2014 Walter J, Ware LB, Matthay MA
• Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome.
  Clinics in chest medicine 2014 Gotts JE, Matthay MA
• Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis.
  Thorax 2014 DePianto DJ, Chandriani S, Abbas AR, Jia G, N'Diaye EN, Caplazi P, Kauder SE, Biswas S, Karnik SK, Ha C, Modrusan Z, Matthay MA, Kukreja J, Collard HR, Egen JG, Wolters PJ, Arron JR
• A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.
  American journal of respiratory and critical care medicine 2014 Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, …
• Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome.
  Critical care medicine 2014 Hsieh SJ, Zhuo H, Benowitz NL, Thompson BT, Liu KD, Matthay MA, Calfee CS, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network, National Heart Lung and Blood …
• Is there a need for emerging drugs for the acute respiratory distress syndrome?
  Expert opinion on emerging drugs 2014 Fitzgerald M, McAuley DF, Matthay M
• Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2014 Ware LB, Lee JW, Wickersham N, Nguyen J, Matthay MA, Calfee CS, California Transplant Donor Network
• Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2014 Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK
• Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy.
  American journal of physiology. Lung cellular and molecular physiology 2014 Gotts JE, Abbott J, Matthay MA
• Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction.
  Frontiers in physiology 2014 Czikora I, Sridhar S, Gorshkov B, Alieva IB, Kasa A, Gonzales J, Potapenko O, Umapathy NS, Pillich H, Rick FG, Block NL, Verin AD, Chakraborty T, Matthay MA, Schally AV, Lucas R
• Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.
  Annals of intensive care 2014 Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, …
• Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study.
  Journal of intensive care 2014 Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu KD, Calfee CS
• Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*.
  Critical care medicine 2014 Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, …
• Translational studies in the ex vivo human lung.
  Respiratory investigation 2014 Sakuma T, Matthay MA
• Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury.
  American journal of respiratory and critical care medicine 2014 Shyamsundar M, McAuley DF, Ingram RJ, Gibson DS, O'Kane D, McKeown ST, Edwards A, Taggart C, Elborn JS, Calfee CS, Matthay MA, O'Kane CM
• Accumulation of BDCA1⁺ dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma.
  PloS one 2014 Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS
• Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia.
  Thorax 2014 Asmussen S, Ito H, Traber DL, Lee JW, Cox RA, Hawkins HK, McAuley DF, McKenna DH, Traber LD, Zhuo H, Wilson J, Herndon DN, Prough DS, Liu KD, Matthay MA, Enkhbaatar P
• Resolution of pulmonary edema. Thirty years of progress.
  American journal of respiratory and critical care medicine 2014 Matthay MA
• Correspondence to: soliciting strategies for developing cell-based reference materials to advance mesenchymal stem/stromal cell research and clinical translation.
  Stem cells and development 2014 McKenna D, Matthay MA, Pati S
• Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials.
  The Lancet. Respiratory medicine 2014 Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA, NHLBI ARDS Network
• Rosuvastatin for sepsis-associated acute respiratory distress syndrome.
  The New England journal of medicine 2014 National Heart, Lung, and Blood Institute ARDS Clinical Trials Network, Truwit JD, Bernard GR, Steingrub J, Matthay MA, Liu KD, Albertson TE, Brower RG, Shanholtz C, Rock P, Douglas IS, deBoisblanc BP…
• Mechanical ventilation in acute hypoxemic respiratory failure: a review of new strategies for the practicing hospitalist.
  Journal of hospital medicine 2014 Wilson JG, Matthay MA
• Applying metabolomics to uncover novel biology in ARDS.
  American journal of physiology. Lung cellular and molecular physiology 2014 Rogers AJ, Matthay MA
• Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury.
  American journal of physiology. Lung cellular and molecular physiology 2014 Goolaerts A, Pellan-Randrianarison N, Larghero J, Vanneaux V, Uzunhan Y, Gille T, Dard N, Planès C, Matthay MA, Clerici C
• A randomized trial of the effects of nebulized albuterol on pulmonary edema in brain-dead organ donors.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2014 Ware LB, Landeck M, Koyama T, Zhao Z, Singer J, Kern R, Neidlinger N, Nguyen J, Johnson E, Janz DR, Bernard GR, Lee JW, Matthay MA, California Transplant Donor Network
• Is there still a role for the lung injury score in the era of the Berlin definition ARDS?
  Annals of intensive care 2014 Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB
• Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation.
  American journal of physiology. Lung cellular and molecular physiology 2014 McAuley DF, Curley GF, Hamid UI, Laffey JG, Abbott J, McKenna DH, Fang X, Matthay MA, Lee JW
• Mesenchymal stromal (stem) cell therapy: an emerging immunomodulatory strategy for the adjunctive treatment of sepsis.
  American journal of respiratory and critical care medicine 2014 Liles WC, Matthay MA, Dos Santos CC, Weiss DJ, Stewart DJ
• Metabolomic derangements are associated with mortality in critically ill adult patients.
  PloS one 2014 Rogers AJ, McGeachie M, Baron RM, Gazourian L, Haspel JA, Nakahira K, Fredenburgh LE, Hunninghake GM, Raby BA, Matthay MA, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore S, Langley RJ, Choi AM
• Reperfusion pulmonary edema in children with tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries undergoing unifocalization procedures: A pilot study examining potential pathophysiologic mechanisms and clinical significance.
  The Journal of thoracic and cardiovascular surgery 2014 Asija R, Roth SJ, Hanley FL, Peng L, Liu K, Abbott J, Zhuo H, Matthay M
• One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome.
  Intensive care medicine 2014 Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN
• TGF-β and lung fluid balance in ARDS.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Frank JA, Matthay MA
• Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial.
  Annals of surgery 2014 Shyamsundar M, McAuley DF, Shields MO, MacSweeney R, Duffy MJ, Johnston JR, McGuigan J, Backman JT, Calfee CS, Matthay MM, Griffiths MJ, McDowell C, Elborn SJ, O'Kane CM
• Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice.
  Stem cells (Dayton, Ohio) 2014 Zhu YG, Feng XM, Abbott J, Fang XH, Hao Q, Monsel A, Qu JM, Matthay MA, Lee JW
• The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial.
  Respiratory care 2013 Kallet RH, Zhuo H, Liu KD, Calfee CS, Matthay MA, National Heart Lung and Blood Institute ARDS Network Investigators
• Treating ARDS: new hope for a tough problem.
  The Lancet. Respiratory medicine 2013 Gotts JE, Matthay MA
• Cystic fibrosis epithelial cell and bacterial binding.
  American journal of physiology. Lung cellular and molecular physiology 2013 Engel J, Matthay M
• Prognostic and diagnostic value of plasma soluble suppression of tumorigenicity-2 concentrations in acute respiratory distress syndrome.
  Critical care medicine 2013 Bajwa EK, Volk JA, Christiani DC, Harris RS, Matthay MA, Thompson BT, Januzzi JL, National Heart, Lung and Blood Institute Acute Respiratory Distress Syndrome Network
• Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome.
  Critical care (London, England) 2013 Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR, May AK, Calfee CS, Matthay MA
• Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury.
  Annals of intensive care 2013 Brown LM, Calfee CS, Howard JP, Craig TR, Matthay MA, McAuley DF
• Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic.
  Seminars in respiratory and critical care medicine 2013 Hendrickson CM, Matthay MA
• Acute cor pulmonale in ARDS.
  Intensive care medicine 2013 Vieillard-Baron A, Price LC, Matthay MA
• Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012.
  American journal of respiratory and critical care medicine 2013 Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell …
• Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*.
  Critical care medicine 2013 Levitt JE, Calfee CS, Goldstein BA, Vojnik R, Matthay MA
• Mesenchymal stem cells and idiopathic pulmonary fibrosis. Potential for clinical testing.
  American journal of respiratory and critical care medicine 2013 Toonkel RL, Hare JM, Matthay MA, Glassberg MK
• Reply: idiopathic pulmonary fibrosis: a degenerative disease requiring a regenerative approach.
  American journal of respiratory and critical care medicine 2013 Glassberg MK, Hare JM, Toonkel RL, Matthay MA
• Sugar administration is an effective adjunctive therapy in the treatment of Pseudomonas aeruginosa pneumonia.
  American journal of physiology. Lung cellular and molecular physiology 2013 Bucior I, Abbott J, Song Y, Matthay MA, Engel JN
• Cell therapy for lung disease: a step forward.
  Chest 2013 Gotts JE, Matthay MA
• The acute respiratory distress syndrome in 2013.
  Translational respiratory medicine 2013 Matthay MA, Song Y, Bai C, Jones KD
• HMGB1 accelerates alveolar epithelial repair via an IL-1β- and αvβ6 integrin-dependent activation of TGF-β1.
  PloS one 2013 Pittet JF, Koh H, Fang X, Iles K, Christiaans S, Anjun N, Wagener BM, Park DW, Zmijewski JW, Matthay MA, Roux J
• Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients.
  American journal of respiratory and critical care medicine 2013 Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS
• The Berlin definition of ARDS versus pathological evidence of diffuse alveolar damage.
  American journal of respiratory and critical care medicine 2013 Thompson BT, Matthay MA
• The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.
  The Journal of clinical investigation 2013 Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A
• Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria.
  American journal of respiratory and critical care medicine 2013 Lee JW, Krasnodembskaya A, McKenna DH, Song Y, Abbott J, Matthay MA
• Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice.
  Journal of immunology (Baltimore, Md. : 1950) 2013 Seeley EJ, Barry SS, Narala S, Matthay MA, Wolters PJ
• Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy.
  The Journal of clinical investigation 2013 Seeley EJ, Rosenberg P, Matthay MA
• Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction--a randomised placebo-controlled trial (KARE): study protocol.
  Trials 2013 Cross LJ, O'Kane CM, McDowell C, Elborn JJ, Matthay MA, McAuley DF
• Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome.
  Molecular medicine (Cambridge, Mass.) 2013 Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M
• Activation of the heat shock response attenuates the interleukin 1β-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport.
  Shock (Augusta, Ga.) 2013 Howard M, Roux J, Iles KE, Miyazawa B, Christiaans S, Anjum N, Dickinson DA, Goolaerts A, Matthay MA, Pittet JF
• Risk factors and outcomes in transfusion-associated circulatory overload.
  The American journal of medicine 2013 Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P, TRALI Study Group
• From protective ventilation to super-protective ventilation for acute respiratory distress syndrome.
  Intensive care medicine 2013 Schultz MJ, Juffermans NP, Matthay MA
• Cecal ligation model of sepsis in mice: new insights.
  Critical care medicine 2013 Bastarache JA, Matthay MA
• Hyperoxic acute lung injury.
  Respiratory care 2013 Kallet RH, Matthay MA
• Regulation and repair of the alveolar-capillary barrier in acute lung injury.
  Annual review of physiology 2013 Bhattacharya J, Matthay MA
• IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Roux J, McNicholas CM, Carles M, Goolaerts A, Houseman BT, Dickinson DA, Iles KE, Ware LB, Matthay MA, Pittet JF
• Novel aspects of urokinase function in the injured lung: role of α2-macroglobulin.
  American journal of physiology. Lung cellular and molecular physiology 2012 Komissarov AA, Stankowska D, Krupa A, Fudala R, Florova G, Florence J, Fol M, Allen TC, Idell S, Matthay MA, Kurdowska AK
• Beta-adrenergic receptor polymorphisms and cardiac graft function in potential organ donors.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012 Khush KK, Pawlikowska L, Menza RL, Goldstein BA, Hayden V, Nguyen J, Kim H, Poon A, Sapru A, Matthay MA, Kwok PY, Young WL, Baxter-Lowe LA, Zaroff JG
• Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials.
  American journal of physiology. Lung cellular and molecular physiology 2012 Agrawal A, Zhuo H, Brady S, Levitt J, Steingrub J, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Matthay MA, Liu KD
• The acute respiratory distress syndrome.
  The Journal of clinical investigation 2012 Matthay MA, Ware LB, Zimmerman GA
• The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2012 Zeyed YF, Bastarache JA, Matthay MA, Ware LB
• Clinical evidence of early acute lung injury often precedes the diagnosis of ALI.
  Journal of intensive care medicine 2012 Rackley CR, Levitt JE, Zhuo H, Matthay MA, Calfee CS
• Clinical review: Early treatment of acute lung injury--paradigm shift toward prevention and treatment prior to respiratory failure.
  Critical care (London, England) 2012 Levitt JE, Matthay MA
• Inflection points in sepsis biology: from local defense to systemic organ injury.
  American journal of physiology. Lung cellular and molecular physiology 2012 Seeley EJ, Matthay MA, Wolters PJ
• Cell-based therapy for acute lung injury: are we there yet?
  Anesthesiology 2012 Lee JW, Zhu Y, Matthay MA
• Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance.
  Critical care medicine 2012 Calfee CS, Gallagher D, Abbott J, Thompson BT, Matthay MA, NHLBI ARDS Network
• The adenosine 2A receptor agonist GW328267C improves lung function after acute lung injury in rats.
  American journal of physiology. Lung cellular and molecular physiology 2012 Folkesson HG, Kuzenko SR, Lipson DA, Matthay MA, Simmons MA
• Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability.
  American journal of respiratory cell and molecular biology 2012 Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum …
• Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential.
  Stem cells translational medicine 2012 Nazarov I, Lee JW, Soupene E, Etemad S, Knapik D, Green W, Bashkirova E, Fang X, Matthay MA, Kuypers FA, Serikov VB
• IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.
  American journal of physiology. Lung cellular and molecular physiology 2012 Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D
• Progress in modelling acute lung injury in a pre-clinical mouse model.
  The European respiratory journal 2012 Matthay MA, Howard JP
• Mesenchymal stem cells and the stem cell niche: a new chapter.
  American journal of physiology. Lung cellular and molecular physiology 2012 Gotts JE, Matthay MA
• Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes.
  American journal of physiology. Lung cellular and molecular physiology 2012 Krasnodembskaya A, Samarani G, Song Y, Zhuo H, Su X, Lee JW, Gupta N, Petrini M, Matthay MA
• Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis.
  Histopathology 2012 Cha SI, Chang CS, Kim EK, Lee JW, Matthay MA, Golden JA, Elicker BM, Jones K, Collard HR, Wolters PJ
• The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012 Sapru A, Zaroff JG, Pawlikowska L, Liu KD, Khush KK, Baxter-Lowe LA, Hayden V, Menza RL, Convery M, Lo V, Poon A, Kim H, Young WL, Kukreja J, Matthay MA, DOGMATIC Study Investigators
• Quantifying the severity of acute lung injury using dead-space ventilation: should the lung injury score be updated?
  Respiratory care 2012 Kallet RH, Alonso JA, Matthay MA
• Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors.
  Clinical transplantation 2012 Ware LB, Neyrinck A, O'Neal HR, Lee JW, Landeck M, Johnson E, Calfee CS, Matthay MA, California Transplant Donor Network
• Anti-inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Bosmann M, Grailer JJ, Zhu K, Matthay MA, Sarma JV, Zetoune FS, Ward PA
• Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma.
  PloS one 2012 Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, …
• Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Lucas R, Sridhar S, Rick FG, Gorshkov B, Umapathy NS, Yang G, Oseghale A, Verin AD, Chakraborty T, Matthay MA, Zemskov EA, White R, Block NL, Schally AV
• Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia.
  Thorax 2012 Gupta N, Krasnodembskaya A, Kapetanaki M, Mouded M, Tan X, Serikov V, Matthay MA
• Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow.
  American journal of physiology. Lung cellular and molecular physiology 2011 Datar SA, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay MA, Fineman JR
• The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.
  Chest 2011 Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA, National Heart, Lung, and Blood Institute ARDS Network
• A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation.
  Critical care medicine 2011 Brown LM, Calfee CS, Matthay MA, Brower RG, Thompson BT, Checkley W, National Institutes of Health Acute Respiratory Distress Syndrome Network Investigators
• Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes.
  Critical care medicine 2011 Liu KD, Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, Matthay MA, Wright P, Peterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD, National Institutes of Health National Heart, Lung, and Blood …
• Transfusion-related acute lung injury: incidence and risk factors.
  Blood 2011 Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, …
• Prognostic value of pulmonary dead space in patients with the acute respiratory distress syndrome.
  Critical care (London, England) 2011 Matthay MA, Kallet RH
• Acute lung failure.
  Seminars in respiratory and critical care medicine 2011 Mac Sweeney R, McAuley DF, Matthay MA
• Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury.
  American journal of respiratory and critical care medicine 2011 National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials, Matthay MA, Brower RG, Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH, Liu KD, …
• Physiology, reductionism, and translational medicine: the right mix.
  American journal of physiology. Lung cellular and molecular physiology 2011 Pitt BR, Christman JW, Gunst SJ, Matthay MA, Stevens T, Ware LB
• Clinical review: Thinking outside the box--an iconoclastic view of current practice.
  Critical care (London, England) 2011 Singer M, Matthay MA
• Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs.
  The American journal of pathology 2011 Rokkam D, Lafemina MJ, Lee JW, Matthay MA, Frank JA
• Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial.
  Annals of intensive care 2011 Ware LB, Koyama T, Billheimer D, Landeck M, Johnson E, Brady S, Bernard GR, Matthay MA, California Transplant Donor Network
• Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study.
  Annals of intensive care 2011 Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Matthay MA, Liu KD
• Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors.
  Stem cells (Dayton, Ohio) 2011 Lee JW, Fang X, Krasnodembskaya A, Howard JP, Matthay MA
• Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury.
  Critical care research and practice 2011 Flori HR, Church G, Liu KD, Gildengorin G, Matthay MA
• Mesenchymal stem cells and acute lung injury.
  Critical care clinics 2011 Gotts JE, Matthay MA
• An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals.
  American journal of respiratory cell and molecular biology 2011 Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay MA, Slutsky AS, Kuebler WM, Acute Lung Injury in Animals Study Group
• Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia.
  American journal of respiratory and critical care medicine 2011 Matthay MA, Liu KD
• Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury.
  Respiratory research 2011 Seeley EJ, McAuley DF, Eisner M, Miletin M, Zhuo H, Matthay MA, Kallet RH
• Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis.
  American journal of physiology. Lung cellular and molecular physiology 2011 Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ
• Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury.
  Critical care clinics 2011 Cross LJ, Matthay MA
• Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury.
  Critical care medicine 2011 Calfee CS, Ware LB, Glidden DV, Eisner MD, Parsons PE, Thompson BT, Matthay MA, National Heart, Blood, and Lung Institute Acute Respiratory Distress Syndrome Network
• Active and passive cigarette smoking and acute lung injury after severe blunt trauma.
  American journal of respiratory and critical care medicine 2011 Calfee CS, Matthay MA, Eisner MD, Benowitz N, Call M, Pittet JF, Cohen MJ
• Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status.
  Critical care (London, England) 2011 Rice TW, Ware LB, Haponik EF, Chiles C, Wheeler AP, Bernard GR, Steingrub JS, Hite RD, Matthay MA, Wright P, Ely EW, NIH NHLBI ARDS Network
• Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice.
  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2011 Su X, Looney MR, Su HE, Lee JW, Song Y, Matthay MA
• Informed consent in research to improve the number and quality of deceased donor organs.
  Critical care medicine 2011 Rey MM, Ware LB, Matthay MA, Bernard GR, McGuire AL, Caplan AL, Halpern SD
• Single-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilization.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2011 Sapru A, Pawlikowska L, Liu KD, Khush KK, Ann-Baxter-Lowe L, Hayden V, Menza RL, Convery M, Poon A, Landeck M, Zaroff JG, Matthay MA, DOGMATIC Study Investigators
• Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells.
  American journal of physiology. Lung cellular and molecular physiology 2011 Yamakawa N, Uchida T, Matthay MA, Makita K
• Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury.
  The Journal of biological chemistry 2011 Finigan JH, Faress JA, Wilkinson E, Mishra RS, Nethery DE, Wyler D, Shatat M, Ware LB, Matthay MA, Mason R, Silver RF, Kern JA
• Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients.
  Critical care medicine 2011 Hsieh SJ, Ware LB, Eisner MD, Yu L, Jacob P, Havel C, Goniewicz ML, Matthay MA, Benowitz NL, Calfee CS
• The acute respiratory distress syndrome: pathogenesis and treatment.
  Annual review of pathology 2011 Matthay MA, Zemans RL
• Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37.
  Stem cells (Dayton, Ohio) 2010 Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA
• Stem cells in sepsis and acute lung injury.
  Critical care medicine 2010 Cribbs SK, Matthay MA, Martin GS
• The utility of clinical predictors of acute lung injury: towards prevention and earlier recognition.
  Expert review of respiratory medicine 2010 Levitt JE, Matthay MA
• Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury.
  Anatomical record (Hoboken, N.J. : 2007) 2010 Lee JS, Su X, Rackley C, Matthay MA, Gupta N
• Mesenchymal stem cells for acute lung injury: preclinical evidence.
  Critical care medicine 2010 Matthay MA, Goolaerts A, Howard JP, Lee JW
• Therapeutic potential of mesenchymal stem cells for severe acute lung injury.
  Chest 2010 Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu KD, Calfee CS, Lee JW
• Thinking outside the box: Introduction.
  Critical care medicine 2010 Singer M, Matthay MA
• The influence of race on the development of acute lung injury in trauma patients.
  American journal of surgery 2010 Brown LM, Kallet RH, Matthay MA, Dicker RA
• Pathophysiology of transfusion-related acute lung injury.
  Current opinion in hematology 2010 Looney MR, Gilliss BM, Matthay MA
• Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients.
  Critical care medicine 2010 Ong T, McClintock DE, Kallet RH, Ware LB, Matthay MA, Liu KD
• Assessing the quantity of pulmonary edema in critically ill children.
  Critical care (London, England) 2010 McAuley DF, Brown LM, Matthay MA
• Advances and challenges in translating stem cell therapies for clinical diseases.
  Translational research : the journal of laboratory and clinical medicine 2010 Matthay MA
• Alveolar fluid clearance is faster in women with acute lung injury compared to men.
  Journal of critical care 2010 Bastarache JA, Ong T, Matthay MA, Ware LB
• Acute lung injury: epidemiology, pathogenesis, and treatment.
  Journal of aerosol medicine and pulmonary drug delivery 2010 Johnson ER, Matthay MA
• Acute respiratory distress syndrome after surgery: can the risk be decreased?
  Anesthesia and analgesia 2010 Matthay MA, Jayr C
• Therapeutic strategies for severe acute lung injury.
  Critical care medicine 2010 Diaz JV, Brower R, Calfee CS, Matthay MA
• Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1.
  The Journal of biological chemistry 2010 Fang X, Neyrinck AP, Matthay MA, Lee JW
• Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials.
  Critical care medicine 2010 Cooke CR, Erickson SE, Watkins TR, Matthay MA, Hudson LD, Rubenfeld GD
• Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock.
  Critical care medicine 2010 Calfee CS, Thompson BT, Parsons PE, Ware LB, Matthay MA, Wong HR
• Update on acute lung injury and critical care medicine 2009.
  American journal of respiratory and critical care medicine 2010 Matthay MA, Idell S
• Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis.
  The Journal of trauma 2010 Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay MA, May AK, Ware LB
• Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis.
  American journal of physiology. Lung cellular and molecular physiology 2010 Collard HR, Calfee CS, Wolters PJ, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay MA, Kim DS
• Regulated gene expression in cultured type II cells of adult human lung.
  American journal of physiology. Lung cellular and molecular physiology 2010 Ballard PL, Lee JW, Fang X, Chapin C, Allen L, Segal MR, Fischer H, Illek B, Gonzales LW, Kolla V, Matthay MA
• Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70.
  Thorax 2010 Howard M, Roux J, Lee H, Miyazawa B, Lee JW, Gartland B, Howard AJ, Matthay MA, Carles M, Pittet JF
• Simulation of lung alveolar epithelial wound healing in vitro.
  Journal of the Royal Society, Interface 2010 Kim SH, Matthay MA, Mostov K, Hunt CA
• Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Diep BA, Chan L, Tattevin P, Kajikawa O, Martin TR, Basuino L, Mai TT, Marbach H, Braughton KR, Whitney AR, Gardner DJ, Fan X, Tseng CW, Liu GY, Badiou C, Etienne J, Lina G, Matthay MA, DeLeo FR, …
• Clinical immunology: Culprits with evolutionary ties.
  Nature 2010 Calfee CS, Matthay MA
• Standards and recommendations for quantitative assessment of lung structure in research.
  American journal of physiology. Lung cellular and molecular physiology 2010 Matthay MA
• Measuring the quantity of pulmonary edema in clinical lung injury.
  Critical care medicine 2010 Brown LM, Matthay MA
• Thirty years of critical care medicine.
  Critical care (London, England) 2010 Vincent JL, Singer M, Marini JJ, Moreno R, Levy M, Matthay MA, Pinsky M, Rhodes A, Ferguson ND, Evans T, Annane D, Hall JB
• Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism.
  The Journal of biological chemistry 2009 Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF
• Mesenchymal stem cells for the prevention of bronchopulmonary dysplasia: delivering the secretome.
  American journal of respiratory and critical care medicine 2009 Abman SH, Matthay MA
• Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Su X, Matthay MA, Malik AB
• Laminin gamma2 fragments are increased in the circulation of patients with early phase acute lung injury.
  Intensive care medicine 2009 Katayama M, Ishizaka A, Sakamoto M, Fujishima S, Sekiguchi K, Asano K, Betsuyaku T, Kotani T, Ware LB, Matthay MA, Hashimoto S
• Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury.
  Pediatric pulmonology 2009 Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman JR, Flori H
• Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury.
  Chest 2009 Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT, Brower RG, Standiford TJ, Martin TR, Matthay MA, NHLBI ARDS Clinical Trials Network
• Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury.
  Intensive care medicine 2009 Sapru A, Curley MA, Brady S, Matthay MA, Flori H
• Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.
  The Journal of clinical investigation 2009 Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA
• Potential application of mesenchymal stem cells in acute lung injury.
  Expert opinion on biological therapy 2009 Lee JW, Gupta N, Serikov V, Matthay MA
• Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio.
  The European respiratory journal 2009 Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA
• Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Lee JW, Fang X, Gupta N, Serikov V, Matthay MA
• Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channel.
  American journal of respiratory cell and molecular biology 2009 Goolaerts A, Roux J, Ganter MT, Shlyonsky V, Chraibi A, Stéphane R, Mies F, Matthay MA, Naeije R, Sariban-Sohraby S, Howard M, Pittet JF
• Comparison of two non-bronchoscopic methods for evaluating inflammation in patients with acute hypoxaemic respiratory failure.
  Critical care (London, England) 2009 Colucci G, Domenighetti G, Della Bruna R, Bonilla J, Limoni C, Matthay MA, Martin TR
• NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice.
  American journal of respiratory and critical care medicine 2009 Carnesecchi S, Deffert C, Pagano A, Garrido-Urbani S, Métrailler-Ruchonnet I, Schäppi M, Donati Y, Matthay MA, Krause KH, Barazzone Argiroffo C
• Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value.
  American journal of physiology. Lung cellular and molecular physiology 2009 Brown LM, Liu KD, Matthay MA
• Clara cell protein CC16. A new lung epithelial biomarker for acute lung injury.
  Chest 2009 McAuley DF, Matthay MA
• Inhaled activated protein C: a novel therapy for acute lung injury?
  Critical care (London, England) 2009 Liu KD, Looney MR, Matthay MA
• Protective mechanisms of activated protein C in severe inflammatory disorders.
  British journal of pharmacology 2009 Neyrinck AP, Liu KD, Howard JP, Matthay MA
• 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia.
  Anesthesiology 2009 Sapru A, Hansen H, Ajayi T, Brown R, Garcia O, Zhuo H, Wiemels J, Matthay MA, Wiener-Kronish J
• Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2009 Church GD, Matthay MA, Liu K, Milet M, Flori HR
• Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery.
  Pediatric pulmonology 2009 Ong T, Stuart-Killion RB, Daniel BM, Presnell LB, Zhuo H, Matthay MA, Liu KD
• Recent trends in acute lung injury mortality: 1996-2005.
  Critical care medicine 2009 Erickson SE, Martin GS, Davis JL, Matthay MA, Eisner MD, NIH NHLBI ARDS Network
• Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2009 Su X, Looney MR, Gupta N, Matthay MA
• Mesenchymally "stemming" angiogenesis.
  Blood 2009 Matthay MA
• Neutrophil sandwiches injure the microcirculation.
  Nature medicine 2009 Looney MR, Matthay MA
• Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosis.
  Anatomical record (Hoboken, N.J. : 2007) 2009 Su X, Matthay MA
• Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers.
  American journal of respiratory and critical care medicine 2009 Shyamsundar M, McKeown ST, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF
• A computational approach to understand in vitro alveolar morphogenesis.
  PloS one 2009 Kim SH, Yu W, Mostov K, Matthay MA, Hunt CA
• The pathogenetic and prognostic value of biologic markers in acute lung injury.
  Journal of intensive care medicine 2009 Levitt JE, Gould MK, Ware LB, Matthay MA
• Identification of early acute lung injury at initial evaluation in an acute care setting prior to the onset of respiratory failure.
  Chest 2009 Levitt JE, Bedi H, Calfee CS, Gould MK, Matthay MA
• The role of angiotensin-converting enzyme inhibition in endotoxin-induced lung injury in rats.
  Critical care medicine 2009 Neyrinck AP, Matthay MA
• Racial and ethnic disparities in mortality from acute lung injury.
  Critical care medicine 2009 Erickson SE, Shlipak MG, Martin GS, Wheeler AP, Ancukiewicz M, Matthay MA, Eisner MD, National Institutes of Health National Heart, Lung, and Blood Institute Acute Respiratory Distress S
• Anti-chemokine autoantibody:chemokine immune complexes activate endothelial cells via IgG receptors.
  American journal of respiratory cell and molecular biology 2008 Krupa A, Fudala R, Stankowska D, Loyd T, Allen TC, Matthay MA, Gryczynski Z, Gryczynski I, Mettikolla YV, Kurdowska AK
• Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway.
  Free radical biology & medicine 2008 Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay MA, Schopfer FJ, Baker PR, Agarwal A, Freeman BA
• Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs.
  Chest 2008 Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA
• Beyond fishing: the role of discovery proteomics in mechanistic lung research.
  American journal of physiology. Lung cellular and molecular physiology 2008 Ware LB, Matthay MA
• Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury.
  Thorax 2008 Looney MR, Esmon CT, Matthay MA
• Reasons for nonenrollment in a clinical trial of acute lung injury.
  Chest 2008 Glassberg AE, Luce JM, Matthay MA, National Heart, Lung, and Blood Institute Clinical Trials Network
• Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury.
  Intensive care medicine 2008 Calfee CS, Eisner MD, Parsons PE, Thompson BT, Conner ER, Matthay MA, Ware LB, NHLBI Acute Respiratory Distress Syndrome Clinical Trials Network
• Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury.
  Thorax 2008 Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA, NHLBI ARDS Network
• Predictors of mortality in acute lung injury during the era of lung protective ventilation.
  Thorax 2008 Seeley E, McAuley DF, Eisner M, Miletin M, Matthay MA, Kallet RH
• Randomized clinical trial of activated protein C for the treatment of acute lung injury.
  American journal of respiratory and critical care medicine 2008 Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay MA
• Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion.
  Critical care medicine 2008 Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA
• CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Su X, Johansen M, Looney MR, Brown EJ, Matthay MA
• Novel molecular strategy to prevent pulmonary edema.
  Critical care medicine 2008 Matthay MA, Berthiaume Y
• Measurement of extravascular lung water in patients with pulmonary edema.
  American journal of physiology. Lung cellular and molecular physiology 2008 Matthay MA
• Protein C as a surrogate end-point for clinical trials of sepsis.
  Critical care (London, England) 2008 Liu KD, Matthay MA
• Treatment of acute lung injury: clinical and experimental studies.
  Proceedings of the American Thoracic Society 2008 Matthay MA
• Aerosolized beta-adrenergic agonist therapy reduces pulmonary edema following lung surgery.
  Chest 2008 Matthay MA, Calfee CS
• Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury.
  Critical care (London, England) 2008 McClintock D, Zhuo H, Wickersham N, Matthay MA, Ware LB
• Bone marrow-derived cells participate in stromal remodeling of the lung following acute bacterial pneumonia in mice.
  Lung 2008 Serikov VB, Mikhaylov VM, Krasnodembskay AD, Matthay MA
• A framework and mechanistically focused, in silico method for enabling rational translational research.
  Summit on translational bioinformatics 2008 Hunt CA, Baranzini S, Matthay MA, Park S
• Beta2 adrenergic agonist therapy may enhance alveolar epithelial repair in patients with acute lung injury.
  Thorax 2008 Matthay MA, Lee J
• Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity.
  American journal of physiology. Lung cellular and molecular physiology 2008 Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay MA, Ware LB
• Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.
  Circulation research 2008 Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF
• Advances in critical care for the nephrologist: acute lung injury/ARDS.
  Clinical journal of the American Society of Nephrology : CJASN 2008 Liu KD, Matthay MA
• Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors.
  Journal of immunology (Baltimore, Md. : 1950) 2008 White KE, Ding Q, Moore BB, Peters-Golden M, Ware LB, Matthay MA, Olman MA
• Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury.
  Critical care medicine 2007 Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA, National Heart, Lung, and Blood Institute ARDS Network Clinical Trials Group
• Lung epithelial cells induce endodermal differentiation in mouse mesenchymal bone marrow stem cells by paracrine mechanism.
  Tissue engineering 2007 Popov BV, Serikov VB, Petrov NS, Izusova TV, Gupta N, Matthay MA
• The role of protein C in sepsis.
  Current infectious disease reports 2007 Looney MR, Matthay MA
• Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders.
  Critical care medicine 2007 Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA, Acute Respiratory Distress Syndrome Network, National Heart, Lung, and Blood Institute
• Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade.
  Thorax 2007 Frank JA, Pittet JF, Wray C, Matthay MA
• Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway.
  American journal of physiology. Renal physiology 2007 Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE
• Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice.
  Anatomical record (Hoboken, N.J. : 2007) 2007 Serikov VB, Popov B, Mikhailov VM, Gupta N, Matthay MA
• Surfactant treatment of aspiration-induced lung injury in children.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2007 Matthay MA, Taeusch W
• Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA
• Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome.
  Critical care medicine 2007 Ware LB, Matthay MA, Parsons PE, Thompson BT, Januzzi JL, Eisner MD, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Networ
• Workshop summary: phosgene-induced pulmonary toxicity revisited: appraisal of early and late markers of pulmonary injury from animal models with emphasis on human significance.
  Inhalation toxicology 2007 Pauluhn J, Carson A, Costa DL, Gordon T, Kodavanti U, Last JA, Matthay MA, Pinkerton KE, Sciuto AM
• Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2007 Calfee CS, Budev MM, Matthay MA, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes JL, deCamp MM, Arroliga AC
• Pulmonary barriers to pneumonia and sepsis.
  Nature medicine 2007 Matthay MA, Su X
• Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells.
  The Journal of biological chemistry 2007 Lee JW, Fang X, Dolganov G, Fremont RD, Bastarache JA, Ware LB, Matthay MA
• Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury.
  Chest 2007 Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Liu KD, Matthay MA
• Alveolar edema fluid clearance and acute lung injury.
  Respiratory physiology & neurobiology 2007 Berthiaume Y, Matthay MA
• Anti-IL-8 autoantibody:IL-8 immune complexes suppress spontaneous apoptosis of neutrophils.
  American journal of physiology. Lung cellular and molecular physiology 2007 Fudala R, Krupa A, Matthay MA, Allen TC, Kurdowska AK
• Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?
  Annals of surgery 2007 Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF
• MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production.
  American journal of physiology. Lung cellular and molecular physiology 2007 Li CJ, Ning W, Matthay MA, Feghali-Bostwick CA, Choi AM
• Genomics and proteomics of lung disease: conference summary.
  American journal of physiology. Lung cellular and molecular physiology 2007 Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, …
• Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats.
  American journal of respiratory cell and molecular biology 2007 Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA
• Postobstructive pulmonary edema: a case for hydrostatic mechanisms.
  Chest 2007 Fremont RD, Kallet RH, Matthay MA, Ware LB
• Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome.
  American journal of respiratory and critical care medicine 2007 Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA
• The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor.
  Thorax 2007 Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay MA, Ware LB
• Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs.
  American journal of physiology. Lung cellular and molecular physiology 2007 Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA
• Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilation.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2007 Flori HR, Ware LB, Milet M, Matthay MA
• Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis.
  Molecular biology of the cell 2007 Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K
• Nonventilatory treatments for acute lung injury and ARDS.
  Chest 2007 Calfee CS, Matthay MA
• Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies.
  Chest 2006 Frank JA, Parsons PE, Matthay MA
• Pulmonary artery catheter and fluid management in acute lung injury and the acute respiratory distress syndrome.
  Clinics in chest medicine 2006 Heresi GA, Arroliga AC, Wiedemann HP, Weidemann HP, Matthay MA
• Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts.
  American journal of respiratory cell and molecular biology 2006 Ning W, Dong Y, Sun J, Li C, Matthay MA, Feghali-Bostwick CA, Choi AM
• Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation.
  American journal of respiratory cell and molecular biology 2006 Wang L, Bastarache JA, Wickersham N, Fang X, Matthay MA, Ware LB
• Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death.
  Nature medicine 2006 Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA
• Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury.
  American journal of respiratory and critical care medicine 2006 McClintock DE, Ware LB, Eisner MD, Wickersham N, Thompson BT, Matthay MA, National Heart, Lung, and Blood Institute ARDS Network
• Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function.
  American journal of respiratory cell and molecular biology 2006 Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF
• Protein permeability in lung injury: now in real time again?
  Journal of applied physiology (Bethesda, Md. : 1985) 2006 Lee JW, Matthay MA
• Treatment of acute lung injury: historical perspective and potential future therapies.
  Seminars in respiratory and critical care medicine 2006 Levitt JE, Matthay MA
• Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2006 Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA
• Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Godzich M, Hodnett M, Frank JA, Su G, Pespeni M, Angel A, Howard MB, Matthay MA, Pittet JF
• Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways.
  Intensive care medicine 2006 Sapru A, Wiemels JL, Witte JS, Ware LB, Matthay MA
• Beta-2-agonist treatment as a potential therapy for acute inhalational lung injury.
  Critical care medicine 2006 Wiener-Kronish JP, Matthay MA
• Sepsis and stretch: synergistic effects on alveolar epithelial cell death?
  Critical care medicine 2006 Gupta N, Matthay MA
• Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.
  The Journal of clinical investigation 2006 Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D
• Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.
  The Journal of clinical investigation 2006 Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA
• Higher urine desmosine levels are associated with mortality in patients with acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2006 McClintock DE, Starcher B, Eisner MD, Thompson BT, Hayden DL, Church GD, Matthay MA, National Heart, Lung, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network
• Integrating acute lung injury and regulation of alveolar fluid clearance.
  American journal of physiology. Lung cellular and molecular physiology 2006 Guidot DM, Folkesson HG, Jain L, Sznajder JI, Pittet JF, Matthay MA
• Evolving practices in critical care and potential implications for management of acute kidney injury.
  Clinical journal of the American Society of Nephrology : CJASN 2006 Liu KD, Matthay MA, Chertow GM
• Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2006 Ganter MT, Ware LB, Howard M, Roux J, Gartland B, Matthay MA, Fleshner M, Pittet JF
• Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum.
  American journal of respiratory cell and molecular biology 2006 Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay MA
• Animal models of transfusion-related acute lung injury.
  Critical care medicine 2006 Looney MR, Matthay MA
• Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome.
  Journal of intensive care medicine 2006 Cepkova M, Matthay MA
• Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2006 Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA
• Perspectives, translational research, and letters to the editor.
  American journal of physiology. Lung cellular and molecular physiology 2006 Matthay MA, Christman JW, Pitt BR, Schwiebert LM, Stevens T, Ware LB
• Alveolar epithelial ion and fluid transport: recent progress.
  American journal of respiratory cell and molecular biology 2006 Folkesson HG, Matthay MA
• Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome.
  Journal of critical care 2006 Curley MA, Arnold JH, Thompson JE, Fackler JC, Grant MJ, Fineman LD, Cvijanovich N, Barr FE, Molitor-Kirsch S, Steinhorn DM, Matthay MA, Hibberd PL, Pediatric Prone Positioning Study Group
• Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine.
  Critical care medicine 2006 Sakuma T, Gu X, Wang Z, Maeda S, Sugita M, Sagawa M, Osanai K, Toga H, Ware LB, Folkesson G, Matthay MA
• Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats.
  Molecular & cellular proteomics : MCP 2006 Hirsch J, Hansen KC, Choi S, Noh J, Hirose R, Roberts JP, Matthay MA, Burlingame AL, Maher JJ, Niemann CU
• Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury.
  American journal of respiratory and critical care medicine 2006 Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K, Mednick G, Matthay ZA, Matthay MA
• Beta-adrenergic agonist therapy as a potential treatment for acute lung injury.
  American journal of respiratory and critical care medicine 2006 Matthay MA, Abraham E
• Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury.
  Critical care (London, England) 2006 Looney MR, Matthay MA
• Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury.
  Critical care (London, England) 2006 Cepkova M, Brady S, Sapru A, Matthay MA, Church G
• Clinical practice. Acute pulmonary edema.
  The New England journal of medicine 2005 Ware LB, Matthay MA
• TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Han B, Mura M, Andrade CF, Okutani D, Lodyga M, dos Santos CC, Keshavjee S, Matthay M, Liu M
• Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice.
  American journal of physiology. Lung cellular and molecular physiology 2005 Su X, Robriquet L, Folkesson HG, Matthay MA
• Therapeutic value of a lung protective ventilation strategy in acute lung injury.
  Chest 2005 Matthay MA, Calfee CS
• Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses.
  American journal of physiology. Lung cellular and molecular physiology 2005 Folkesson HG, Chapin CJ, Beard LL, Ertsey R, Matthay MA, Kitterman JA
• Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management.
  American journal of respiratory cell and molecular biology 2005 Matthay MA, Zimmerman GA
• High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2005 Ware LB, Fang X, Wang Y, Babcock WD, Jones K, Matthay MA
• Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells.
  American journal of physiology. Lung cellular and molecular physiology 2005 Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA
• Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA
• Leukotrienes in acute lung injury: a potential therapeutic target?
  American journal of respiratory and critical care medicine 2005 Frank JA, Matthay MA
• Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial.
  JAMA 2005 Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, Grant MJ, Barr FE, Cvijanovich NZ, Sorce L, Luckett PM, Matthay MA, Arnold JH
• VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema.
  The European respiratory journal 2005 Ware LB, Kaner RJ, Crystal RG, Schane R, Trivedi NN, McAuley D, Matthay MA
• Recent advances in mechanical ventilation.
  The American journal of medicine 2005 Calfee CS, Matthay MA
• Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells.
  American journal of respiratory cell and molecular biology 2005 Suzuki T, Moraes TJ, Vachon E, Ginzberg HH, Huang TT, Matthay MA, Hollenberg MD, Marshall J, McCulloch CA, Abreu MT, Chow CW, Downey GP
• Accuracy of physiologic dead space measurements in patients with acute respiratory distress syndrome using volumetric capnography: comparison with the metabolic monitor method.
  Respiratory care 2005 Kallet RH, Daniel BM, Garcia O, Matthay MA
• Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance.
  American journal of physiology. Lung cellular and molecular physiology 2005 Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA
• Critical care in AJRCCM 2004.
  American journal of respiratory and critical care medicine 2005 Angus D, Ishizaka A, Matthay M, Lemaire F, Macnee W, Abraham E
• Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway.
  The Journal of biological chemistry 2005 Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF
• In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases.
  American journal of physiology. Lung cellular and molecular physiology 2005 Planès C, Leyvraz C, Uchida T, Angelova MA, Vuagniaux G, Hummler E, Matthay M, Clerici C, Rossier B
• Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury.
  Critical care medicine 2005 Cheng IW, Eisner MD, Thompson BT, Ware LB, Matthay MA, Acute Respiratory Distress Syndrome Network
• Alveolar epithelium: role in lung fluid balance and acute lung injury.
  Proceedings of the American Thoracic Society 2005 Matthay MA, Robriquet L, Fang X
• Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury.
  Critical care medicine 2005 Frank JA, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay MA
• Is there a role for beta-adrenoceptor agonists in the management of acute lung injury and the acute respiratory distress syndrome?
  Treatments in respiratory medicine 2005 McAuley DF, Matthay MA
• Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury.
  Critical care medicine 2005 Parsons PE, Eisner MD, Thompson BT, Matthay MA, Ancukiewicz M, Bernard GR, Wheeler AP, NHLBI Acute Respiratory Distress Syndrome Clinical Trials Network
• Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis.
  The American journal of medicine 2005 Dezfulian C, Shojania K, Collard HR, Kim HM, Matthay MA, Saint S
• Pediatric acute lung injury: prospective evaluation of risk factors associated with mortality.
  American journal of respiratory and critical care medicine 2004 Flori HR, Glidden DV, Rutherford GW, Matthay MA
• Integrated control of lung fluid balance.
  American journal of physiology. Lung cellular and molecular physiology 2004 Mehta D, Bhattacharya J, Matthay MA, Malik AB
• HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in rats.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004 Lee H, Pespeni M, Roux J, Dennery PA, Matthay MA, Pittet JF
• Can nicotine treat sepsis?
  Nature medicine 2004 Matthay MA, Ware LB
• Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2004 Parsons PE, Matthay MA, Ware LB, Eisner MD, National Heart, Lung, Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network
• Acute lung injury and acute respiratory distress syndrome in pregnancy.
  Critical care clinics 2004 Bandi VD, Munnur U, Matthay MA
• Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice.
  Experimental lung research 2004 Su X, Looney M, Robriquet L, Fang X, Matthay MA
• Prognostic value of the pulmonary dead-space fraction during the first 6 days of acute respiratory distress syndrome.
  Respiratory care 2004 Kallet RH, Alonso JA, Pittet JF, Matthay MA
• Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock.
  Blood 2004 Pugin J, Stern-Voeffray S, Daubeuf B, Matthay MA, Elson G, Dunn-Siegrist I
• Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome.
  The New England journal of medicine 2004 Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT, National Heart, Lung, and Blood Institute ARDS Clinical Trials Network
• Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edema.
  Intensive care medicine 2004 Sue RD, Matthay MA, Ware LB
• Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury.
  Critical care medicine 2004 McAuley DF, Frank JA, Fang X, Matthay MA
• Coagulation-dependent mechanisms and asthma.
  The Journal of clinical investigation 2004 Matthay MA, Clements JA
• Proteomics: current techniques and potential applications to lung disease.
  American journal of physiology. Lung cellular and molecular physiology 2004 Hirsch J, Hansen KC, Burlingame AL, Matthay MA
• Transfusion-related acute lung injury: a review.
  Chest 2004 Looney MR, Gropper MA, Matthay MA
• Bench-to-bedside review: the role of the alveolar epithelium in the resolution of pulmonary edema in acute lung injury.
  Critical care (London, England) 2004 Zemans RL, Matthay MA
• Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury.
  American journal of respiratory and critical care medicine 2004 Ware LB, Eisner MD, Thompson BT, Parsons PE, Matthay MA
• Plasma protein C levels in patients with acute lung injury: prognostic significance.
  Critical care medicine 2004 Matthay MA, Ware LB
• H(2)O(2) inhibits alveolar epithelial wound repair in vitro by induction of apoptosis.
  American journal of physiology. Lung cellular and molecular physiology 2004 Geiser T, Ishigaki M, van Leer C, Matthay MA, Broaddus VC
• Mechanisms of alveolar protein clearance in the intact lung.
  American journal of physiology. Lung cellular and molecular physiology 2004 Hastings RH, Folkesson HG, Matthay MA
• Diagnostic utility of B-type natriuretic peptide in patients with acute dyspnea or pleural effusions.
  The American journal of medicine 2004 Zemans RL, Chatterjee K, Matthay MA
• Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system.
  American journal of physiology. Lung cellular and molecular physiology 2004 Fang X, Song Y, Zemans R, Hirsch J, Matthay MA
• Malnutrition impairs alveolar fluid clearance in rat lungs.
  American journal of physiology. Lung cellular and molecular physiology 2004 Sakuma T, Zhao Y, Sugita M, Sagawa M, Toga H, Ishibashi T, Nishio M, Matthay MA
• Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Olman MA, White KE, Ware LB, Simmons WL, Benveniste EN, Zhu S, Pugin J, Matthay MA
• Look before you leap: how do intensivists improve care for critically ill patients?
  The American journal of medicine 2004 Gropper MA, Matthay MA
• Why does acute lung injury have no impact on mortality in patients with major trauma?
  Critical care medicine 2004 McClintock DE, Matthay MA
• Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha.
  The Journal of biological chemistry 2004 Uchida T, Rossignol F, Matthay MA, Mounier R, Couette S, Clottes E, Clerici C
• Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2004 Bowler RP, Duda B, Chan ED, Enghild JJ, Ware LB, Matthay MA, Duncan MW
• Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2004 Krupa A, Kato H, Matthay MA, Kurdowska AK
• Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs.
  Experimental lung research 2004 Wang L, Zhu DM, Su X, Bai CX, Ware LB, Matthay MA
• The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities.
  Infection and immunity 2004 Garrity-Ryan L, Shafikhani S, Balachandran P, Nguyen L, Oza J, Jakobsen T, Sargent J, Fang X, Cordwell S, Matthay MA, Engel JN
• Cytokine-mediated inflammation in acute lung injury.
  Cytokine & growth factor reviews 2003 Goodman RB, Pugin J, Lee JS, Matthay MA
• Pancreatitis-associated acute lung injury: new insights.
  Chest 2003 Pastor CM, Matthay MA, Frossard JL
• Transforming growth factor-beta 1 regulates lung epithelial barrier function and fluid transport.
  American journal of physiology. Lung cellular and molecular physiology 2003 Clerici C, Matthay MA
• Transgenic overexpression of granulocyte macrophage-colony stimulating factor in the lung prevents hyperoxic lung injury.
  The American journal of pathology 2003 Paine R, Wilcoxen SE, Morris SB, Sartori C, Baleeiro CE, Matthay MA, Christensen PJ
• Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure.
  Critical care medicine 2003 Brower RG, Morris A, MacIntyre N, Matthay MA, Hayden D, Thompson T, Clemmer T, Lanken PN, Schoenfeld D, ARDS Clinical Trials Network, National Heart, Lung, and Blood Institute, National Institutes of …
• Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury.
  Thorax 2003 Eisner MD, Parsons P, Matthay MA, Ware L, Greene K, Acute Respiratory Distress Syndrome Network
• Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury.
  Intensive care medicine 2003 Su X, Bai C, Hong Q, Zhu D, He L, Wu J, Ding F, Fang X, Matthay MA
• Acute lung injury and the acute respiratory distress syndrome.
  Critical care clinics 2003 Cheng IW, Matthay MA
• Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome.
  American journal of physiology. Lung cellular and molecular physiology 2003 Ishizaka A, Matsuda T, Albertine KH, Koh H, Tasaka S, Hasegawa N, Kohno N, Kotani T, Morisaki H, Takeda J, Nakamura M, Fang X, Martin TR, Matthay MA, Hashimoto S
• Pulmonary edema fluid antioxidants are depressed in acute lung injury.
  Critical care medicine 2003 Bowler RP, Velsor LW, Duda B, Chan ED, Abraham E, Ware LB, Matthay MA, Day BJ
• Transforming growth factor-beta induces fibrosis in immune cell-depleted lungs.
  American journal of physiology. Lung cellular and molecular physiology 2003 Olman MA, Matthay MA
• Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism.
  The Journal of biological chemistry 2003 Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF
• Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha.
  American journal of respiratory and critical care medicine 2003 Elia N, Tapponnier M, Matthay MA, Hamacher J, Pache JC, Brundler MA, Totsch M, De Baetselier P, Fransen L, Fukuda N, Morel DR, Lucas R
• Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2003 Flori HR, Ware LB, Glidden D, Matthay MA
• Protein C and thrombomodulin in human acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2003 Ware LB, Fang X, Matthay MA
• Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2003 Prabhakaran P, Ware LB, White KE, Cross MT, Matthay MA, Olman MA
• Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group.
  American journal of respiratory and critical care medicine 2003 Matthay MA, Zimmerman GA, Esmon C, Bhattacharya J, Coller B, Doerschuk CM, Floros J, Gimbrone MA, Hoffman E, Hubmayr RD, Leppert M, Matalon S, Munford R, Parsons P, Slutsky AS, Tracey KJ, Ward P, Gail…
• Therapeutic strategies to hasten the resolution of pulmonary edema.
  Critical care medicine 2003 Folkesson HG, Matthay MA
• Prevention of ventilator-associated pneumonia: an evidence-based systematic review.
  Annals of internal medicine 2003 Collard HR, Saint S, Matthay MA
• Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro.
  Experimental cell research 2003 Galiacy S, Planus E, Lepetit H, Féréol S, Laurent V, Ware L, Isabey D, Matthay M, Harf A, d'Ortho MP
• High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance.
  American journal of physiology. Lung cellular and molecular physiology 2003 Frank JA, Pittet JF, Lee H, Godzich M, Matthay MA
• Prognostic value of surfactant proteins A and D in patients with acute lung injury.
  Critical care medicine 2003 Cheng IW, Ware LB, Greene KE, Nuckton TJ, Eisner MD, Matthay MA
• Alveolar fluid clearance in patients with ARDS: does it make a difference?
  Chest 2002 Matthay MA
• Clinical measurement of pulmonary edema.
  Chest 2002 Matthay MA
• Lung edema clearance: 20 years of progress: invited review: alveolar edema fluid clearance in the injured lung.
  Journal of applied physiology (Bethesda, Md. : 1985) 2002 Berthiaume Y, Folkesson HG, Matthay MA
• Meta-analysis of acute lung injury and acute respiratory distress syndrome trials.
  American journal of respiratory and critical care medicine 2002 Brower RG, Matthay M, Schoenfeld D
• Alveolar epithelial fluid transport in acute lung injury: new insights.
  The European respiratory journal 2002 Sartori C, Matthay MA
• Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome.
  The American journal of pathology 2002 Albertine KH, Soulier MF, Wang Z, Ishizaka A, Hashimoto S, Zimmerman GA, Matthay MA, Ware LB
• Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo.
  American journal of physiology. Lung cellular and molecular physiology 2002 Pham I, Uchida T, Planes C, Ware LB, Kaner R, Matthay MA, Clerici C
• Selected contribution: long-term effects of beta(2)-adrenergic receptor stimulation on alveolar fluid clearance in mice.
  Journal of applied physiology (Bethesda, Md. : 1985) 2002 Sartori C, Fang X, McGraw DW, Koch P, Snider ME, Folkesson HG, Matthay MA
• Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung.
  Journal of applied physiology (Bethesda, Md. : 1985) 2002 Ware LB, Fang X, Wang Y, Sakuma T, Hall TS, Matthay MA
• Measuring microvascular blood flow in sepsis--a continuing challenge.
  Lancet (London, England) 2002 Ware LB, Matthay MA
• Science review: mechanisms of ventilator-induced injury.
  Critical care (London, England) 2002 Frank JA, Matthay MA
• Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells.
  The Journal of biological chemistry 2002 Planès C, Blot-Chabaud M, Matthay MA, Couette S, Uchida T, Clerici C
• Central line infections.
  Current opinion in critical care 2002 Lane RK, Matthay MA
• Invited review: Active fluid clearance from the distal air spaces of the lung.
  Journal of applied physiology (Bethesda, Md. : 1985) 2002 Matthay MA, Clerici C, Saumon G
• Time-dependent effect of pneumonectomy on alveolar epithelial fluid clearance in rat lungs.
  The Journal of thoracic and cardiovascular surgery 2002 Sakuma T, Sagawa M, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Matthay MA
• Ventilator-induced lung injury: in vivo and in vitro mechanisms.
  American journal of physiology. Lung cellular and molecular physiology 2002 Matthay MA, Bhattacharya S, Gaver D, Ware LB, Lim LH, Syrkina O, Eyal F, Hubmayr R
• Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier.
  Journal of applied physiology (Bethesda, Md. : 1985) 2002 Jiang J, Song Y, Bai C, Koller BH, Matthay MA, Verkman AS
• Assessment of lungs rejected for transplantation and implications for donor selection.
  Lancet (London, England) 2002 Ware LB, Wang Y, Fang X, Warnock M, Sakuma T, Hall TS, Matthay M
• The pulmonary epithelium is an important mediator of ventilator-induced lung injury.
  Critical care medicine 2002 Matthay MA
• Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney.
  The Journal of physiology 2002 Fang X, Yang B, Matthay MA, Verkman AS
• Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms.
  American journal of physiology. Lung cellular and molecular physiology 2002 Atabai K, Ishigaki M, Geiser T, Ueki I, Matthay MA, Ware LB
• Lung epithelial fluid transport and the resolution of pulmonary edema.
  Physiological reviews 2002 Matthay MA, Folkesson HG, Clerici C
• Enhancing the safety of critically ill patients by reducing urinary and central venous catheter-related infections.
  American journal of respiratory and critical care medicine 2002 Saint S, Savel RH, Matthay MA
• Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure.
  Intensive care medicine 2002 Atabai K, Ware LB, Snider ME, Koch P, Daniel B, Nuckton TJ, Matthay MA
• Activity of pulmonary edema fluid interleukin-8 bound to alpha(2)-macroglobulin in patients with acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2002 Kurdowska AK, Geiser TK, Alden SM, Dziadek BR, Noble JM, Nuckton TJ, Matthay MA
• Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair.
  American journal of physiology. Lung cellular and molecular physiology 2002 Ware LB, Matthay MA
• The pulmonary physician in critical care. 5: Acute lung injury and the acute respiratory distress syndrome: definitions and epidemiology.
  Thorax 2002 Atabai K, Matthay MA
• Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome.
  The New England journal of medicine 2002 Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet JF, Eisner MD, Matthay MA
• Airway pressures and early barotrauma in patients with acute lung injury and acute respiratory distress syndrome.
  American journal of respiratory and critical care medicine 2002 Eisner MD, Thompson BT, Schoenfeld D, Anzueto A, Matthay MA, Acute Respiratory Distress Syndrome Network
• Clinical Acute Lung Injury and Acute Respiratory Distress Syndrome.
  Current treatment options in cardiovascular medicine 2002 Matthay MA, Uchida T, Fang X
• Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholamines.
  American journal of physiology. Lung cellular and molecular physiology 2002 Folkesson HG, Matthay MA, Chapin CJ, Porta NF, Kitterman JA
• Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1.
  Chest 2002 Olman MA, White KE, Ware LB, Cross MT, Zhu S, Matthay MA
• Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in rats.
  Anesthesiology 2002 Laffon M, Jayr C, Barbry P, Wang Y, Folkesson HG, Pittet JF, Clerici C, Matthay MA
• Novel role for CFTR in fluid absorption from the distal airspaces of the lung.
  The Journal of general physiology 2002 Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA
• Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs.
  American journal of respiratory and critical care medicine 2002 Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA
• Stress preconditioning attenuates oxidative injury to the alveolar epithelium of the lung following haemorrhage in rats.
  The Journal of physiology 2002 Pittet JF, Lu LN, Geiser T, Lee H, Matthay MA, Welch WJ
• von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury.
  Critical care medicine 2001 Ware LB, Conner ER, Matthay MA
• Clinicians' approaches to mechanical ventilation in acute lung injury and ARDS.
  Chest 2001 Thompson BT, Hayden D, Matthay MA, Brower R, Parsons PE
• Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment.
  American journal of respiratory cell and molecular biology 2001 Vivona ML, Matthay M, Chabaud MB, Friedlander G, Clerici C
• Keratinocyte growth factor reduces alveolar epithelial susceptibility to in vitro mechanical deformation.
  American journal of physiology. Lung cellular and molecular physiology 2001 Oswari J, Matthay MA, Margulies SS
• Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance.
  American journal of physiology. Lung cellular and molecular physiology 2001 McGraw DW, Fukuda N, James PF, Forbes SL, Woo AL, Lingrel JB, Witte DP, Matthay MA, Liggett SB
• The Role of Protein C in Sepsis.
  Current infectious disease reports 2001 Looney MR, Matthay MA
• Treatment of ARDS.
  Chest 2001 Brower RG, Ware LB, Berthiaume Y, Matthay MA
• Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome.
  American journal of respiratory and critical care medicine 2001 Eisner MD, Thompson T, Hudson LD, Luce JM, Hayden D, Schoenfeld D, Matthay MA, Acute Respiratory Distress Syndrome Network
• Beta1-adrenoceptor stimulation by high-dose terbutaline downregulates terbutaline-stimulated alveolar fluid clearance in ex vivo rat lung.
  Experimental lung research 2001 Sakuma T, Tuchihara C, Ishigaki M, Osanai K, Nambu Y, Toga H, Takahashi K, Ohya N, Inoue M, Matthay MA
• Partial restoration of defective chloride conductance in DeltaF508 CF mice by trimethylamine oxide.
  American journal of physiology. Lung cellular and molecular physiology 2001 Fischer H, Fukuda N, Barbry P, Illek B, Sartori C, Matthay MA
• Rapid alveolar epithelial fluid clearance following lung lavage in pulmonary alveolar proteinosis.
  Chest 2001 Chesnutt MS, Nuckton TJ, Golden J, Folkesson HG, Matthay MA
• Mechanisms of TNF-alpha stimulation of amiloride-sensitive sodium transport across alveolar epithelium.
  American journal of physiology. Lung cellular and molecular physiology 2001 Fukuda N, Jayr C, Lazrak A, Wang Y, Lucas R, Matalon S, Matthay MA
• Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration.
  The Journal of general physiology 2001 Song Y, Jayaraman S, Yang B, Matthay MA, Verkman AS
• TGF-beta is a critical mediator of acute lung injury.
  The Journal of clinical investigation 2001 Pittet JF, Griffiths MJ, Geiser T, Kaminski N, Dalton SL, Huang X, Brown LA, Gotwals PJ, Koteliansky VE, Matthay MA, Sheppard D
• Reactive nitrogen species inhibit alveolar epithelial fluid transport after hemorrhagic shock in rats.
  Journal of immunology (Baltimore, Md. : 1950) 2001 Pittet JF, Lu LN, Morris DG, Modelska K, Welch WJ, Carey HV, Roux J, Matthay MA
• Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome.
  American journal of respiratory and critical care medicine 2001 Ware LB, Matthay MA
• Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism.
  American journal of respiratory and critical care medicine 2001 Geiser T, Atabai K, Jarreau PH, Ware LB, Pugin J, Matthay MA
• Contribution of amiloride-insensitive pathways to alveolar fluid clearance in adult rats.
  Journal of applied physiology (Bethesda, Md. : 1985) 2001 Norlin A, Lu LN, Guggino SE, Matthay MA, Folkesson HG
• Pseudomonas aeruginosa ExoT inhibits in vitro lung epithelial wound repair.
  Cellular microbiology 2001 Geiser TK, Kazmierczak BI, Garrity-Ryan LK, Matthay MA, Engel JN
• Severe sepsis--a new treatment with both anticoagulant and antiinflammatory properties.
  The New England journal of medicine 2001 Matthay MA
• Alveolar epithelial transport. Basic science to clinical medicine.
  American journal of respiratory and critical care medicine 2001 Crandall ED, Matthay MA
• Denopamine, a beta(1)-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs.
  Journal of applied physiology (Bethesda, Md. : 1985) 2001 Sakuma T, Tuchihara C, Ishigaki M, Osanai K, Nambu Y, Toga H, Takahashi K, Ohya N, Kurihara T, Matthay MA
• Etiology of acute pulmonary edema during liver transplantation : a series of cases with analysis of the edema fluid.
  Chest 2001 Yost CS, Matthay MA, Gropper MA
• Increased levels of nitrate and surfactant protein a nitration in the pulmonary edema fluid of patients with acute lung injury.
  American journal of respiratory and critical care medicine 2001 Zhu S, Ware LB, Geiser T, Matthay MA, Matalon S
• Transepithelial sodium and water transport in the lung. Major player and novel therapeutic target in pulmonary edema.
  Advances in experimental medicine and biology 2001 Sartori C, Matthay MA, Scherrer U
• Interleukin-1beta augments in vitro alveolar epithelial repair.
  American journal of physiology. Lung cellular and molecular physiology 2000 Geiser T, Jarreau PH, Atabai K, Matthay MA
• Role of aquaporin water channels in pleural fluid dynamics.
  American journal of physiology. Cell physiology 2000 Song Y, Yang B, Matthay MA, Ma T, Verkman AS
• Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats.
  Journal of applied physiology (Bethesda, Md. : 1985) 2000 Frank JA, Wang Y, Osorio O, Matthay MA
• Alveolar epithelial barrier. Role in lung fluid balance in clinical lung injury.
  Clinics in chest medicine 2000 Matthay MA, Fukuda N, Frank J, Kallet R, Daniel B, Sakuma T
• Relationship of interstitial fluid volume to alveolar fluid clearance in mice: ventilated vs. in situ studies.
  Journal of applied physiology (Bethesda, Md. : 1985) 2000 Fukuda N, Folkesson HG, Matthay MA
• Diabetes mellitus: a negative predictor for the development of acute respiratory distress syndrome from septic shock.
  Critical care medicine 2000 Frank JA, Nuckton TJ, Matthay MA
• Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice.
  The Journal of physiology 2000 Song Y, Fukuda N, Bai C, Ma T, Matthay MA, Verkman AS
• Cost-effectiveness of noninvasive ventilation for acute chronic obstructive pulmonary disease: cashing in too quickly.
  Critical care medicine 2000 Jasmer RM, Matthay MA
• Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema.
  American journal of respiratory cell and molecular biology 2000 Kaner RJ, Ladetto JV, Singh R, Fukuda N, Matthay MA, Crystal RG
• Lung deflation impairs alveolar epithelial fluid transport in ischemic rabbit and rat lungs.
  Transplantation 2000 Sakuma T, Tsukano C, Ishigaki M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Kurihara T, Nishio M, Matthay MA
• The acute respiratory distress syndrome.
  The New England journal of medicine 2000 Ware LB, Matthay MA
• Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.
  The New England journal of medicine 2000 Acute Respiratory Distress Syndrome Network, Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A
• Aquaporin water channels and lung physiology.
  American journal of physiology. Lung cellular and molecular physiology 2000 Verkman AS, Matthay MA, Song Y
• Hypoxia regulates gene expression of alveolar epithelial transport proteins.
  Journal of applied physiology (Bethesda, Md. : 1985) 2000 Clerici C, Matthay MA
• [Amiloride-sensitive sodium channel in the nephron and its activation by vasopressin].
  Annales d'endocrinologie 2000 Coscoy S, de Weille J, Lingueglia E, Fukuda N, Matthay M, Lazdunski M, Barbry P
• Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance.
  American journal of respiratory and critical care medicine 2000 Ordoñez CL, Shaughnessy TE, Matthay MA, Fahy JV
• A novel alveolar type I cell-specific biochemical marker of human acute lung injury.
  American journal of respiratory and critical care medicine 2000 Newman V, Gonzalez RF, Matthay MA, Dobbs LG
• Assessment of prognosis in patients with community-acquired pneumonia who require mechanical ventilation.
  Chest 2000 Pascual FE, Matthay MA, Bacchetti P, Wachter RM
• Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats.
  Journal of applied physiology (Bethesda, Md. : 1985) 2000 Folkesson HG, Norlin A, Wang Y, Abedinpour P, Matthay MA
• Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes.
  The Journal of biological chemistry 2000 Yang B, Fukuda N, van Hoek A, Matthay MA, Ma T, Verkman AS
• Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation.
  Critical care medicine 2000 Abraham E, Matthay MA, Dinarello CA, Vincent JL, Cohen J, Opal SM, Glauser M, Parsons P, Fisher CJ, Repine JE
• Early expression of beta- and gamma-subunits of epithelial sodium channel during human airway development.
  American journal of physiology. Lung cellular and molecular physiology 2000 Gaillard D, Hinnrasky J, Coscoy S, Hofman P, Matthay MA, Puchelle E, Barbry P
• Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patients.
  Critical care medicine 2000 Eberhard LW, Morabito DJ, Matthay MA, Mackersie RC, Campbell AR, Marks JD, Alonso JA, Pittet JF
• Lung fluid transport in aquaporin-5 knockout mice.
  The Journal of clinical investigation 2000 Ma T, Fukuda N, Song Y, Matthay MA, Verkman AS
• Noninvasive ventilation for acute respiratory failure.
  Journal of clinical monitoring and computing 2000 Jasmer RM, Matthay MA
• Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method.
  The Journal of general physiology 2000 Song Y, Ma T, Matthay MA, Verkman AS
• Exacerbation of acute pulmonary edema during assisted mechanical ventilation using a low-tidal volume, lung-protective ventilator strategy.
  Chest 1999 Kallet RH, Alonso JA, Luce JM, Matthay MA
• Health-related quality of life after acute lung injury.
  Critical care medicine 1999 Eisner MD, Matthay MA
• Acid-induced lung injury. Protective effect of anti-interleukin-8 pretreatment on alveolar epithelial barrier function in rabbits.
  American journal of respiratory and critical care medicine 1999 Modelska K, Pittet JF, Folkesson HG, Courtney Broaddus V, Matthay MA
• Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta-agonist therapy.
  Journal of applied physiology (Bethesda, Md. : 1985) 1999 Wang Y, Folkesson HG, Jayr C, Ware LB, Matthay MA
• Interleukin-8 mediates injury from smoke inhalation to both the lung endothelial and the alveolar epithelial barriers in rabbits.
  American journal of respiratory and critical care medicine 1999 Laffon M, Pittet JF, Modelska K, Matthay MA, Young DM
• Interobserver variability in applying a radiographic definition for ARDS.
  Chest 1999 Rubenfeld GD, Caldwell E, Granton J, Hudson LD, Matthay MA
• Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema.
  Journal of applied physiology (Bethesda, Md. : 1985) 1999 Verghese GM, Ware LB, Matthay BA, Matthay MA
• The lectin-like domain of tumor necrosis factor-alpha increases membrane conductance in microvascular endothelial cells and peritoneal macrophages.
  European journal of immunology 1999 Hribar M, Bloc A, van der Goot FG, Fransen L, De Baetselier P, Grau GE, Bluethmann H, Matthay MA, Dunant Y, Pugin J, Lucas R
• alpha-adrenergic blockade restores normal fluid transport capacity of alveolar epithelium after hemorrhagic shock.
  The American journal of physiology 1999 Laffon M, Lu LN, Modelska K, Matthay MA, Pittet JF
• Indomethacin does not influence alveolar liquid clearance in anesthetized sheep or rats.
  Experimental lung research 1999 Berthiaume Y, Folkesson HG, Matthay MA
• Oxidant-mediated lung injury in the acute respiratory distress syndrome.
  Critical care medicine 1999 Matthay MA, Geiser T, Matalon S, Ischiropoulos H
• Acute pulmonary edema after lung transplantation: the pulmonary reimplantation response.
  Chest 1999 Khan SU, Salloum J, O'Donovan PB, Mascha EJ, Mehta AC, Matthay MA, Arroliga AC
• Alveolar epithelial fluid transport can be upregulated simultaneously in rats by two different mechanisms.
  Chest 1999 Wang Y, Jayr C, Folkesson HG, Matthay MA
• Conference summary: acute lung injury.
  Chest 1999 Matthay MA
• Elevated pulmonary edema fluid concentrations of soluble intercellular adhesion molecule-1 in patients with acute lung injury: biological and clinical significance.
  Chest 1999 Conner ER, Ware LB, Modin G, Matthay MA
• HTI56, an integral apical membrane protein of the human alveolar type I cell, is a biochemical marker of acute lung injury.
  Chest 1999 Newman V, Gonzalez R, Matthay M, Dobbs L
• Inhibition of beta-adrenergic-dependent alveolar epithelial clearance by oxidant mechanisms after hemorrhagic shock.
  The American journal of physiology 1999 Modelska K, Matthay MA, Brown LA, Deutch E, Lu LN, Pittet JF
• Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation.
  American journal of respiratory and critical care medicine 1999 Ware LB, Golden JA, Finkbeiner WE, Matthay MA
• The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.
  Cell 1999 Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D
• Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice.
  The Journal of clinical investigation 1999 Bai C, Fukuda N, Song Y, Ma T, Matthay MA, Verkman AS
• The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome.
  Critical care medicine 1999 Pugin J, Verghese G, Widmer MC, Matthay MA
• Alveolar epithelial fluid clearance persists in the presence of moderate left atrial hypertension in sheep.
  Journal of applied physiology (Bethesda, Md. : 1985) 1999 Campbell AR, Folkesson HG, Berthiaume Y, Gutkowska J, Suzuki S, Matthay MA
• Ischemia-reperfusion lung injury in rabbits: mechanisms of injury and protection.
  The American journal of physiology 1999 Sakuma T, Takahashi K, Ohya N, Kajikawa O, Martin TR, Albertine KH, Matthay MA
• Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice.
  The American journal of physiology 1999 Yang B, Folkesson HG, Yang J, Matthay MA, Ma T, Verkman AS
• Role of collagenase in mediating in vitro alveolar epithelial wound repair.
  Journal of cell science 1999 Planus E, Galiacy S, Matthay M, Laurent V, Gavrilovic J, Murphy G, Clérici C, Isabey D, Lafuma C, d'Ortho MP
• Risk reduction in the intensive care unit.
  The American journal of medicine 1998 Saint S, Matthay MA
• Alveolar epithelial fluid transport: basic mechanisms and clinical relevance.
  Proceedings of the Association of American Physicians 1998 Matthay MA, Flori HR, Conner ER, Ware LB
• Pulmonary edema in obstetric patients is rapidly resolved except in the presence of infection or of nitroglycerin tocolysis after open fetal surgery.
  American journal of obstetrics and gynecology 1998 DiFederico EM, Burlingame JM, Kilpatrick SJ, Harrison M, Matthay MA
• Upregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycin.
  The American journal of physiology 1998 Folkesson HG, Nitenberg G, Oliver BL, Jayr C, Albertine KH, Matthay MA
• Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance.
  American journal of respiratory and critical care medicine 1998 Verghese GM, McCormick-Shannon K, Mason RJ, Matthay MA
• Protective ventilation for the acute respiratory distress syndrome.
  The New England journal of medicine 1998 Parsons PE, Matthay M
• A mouse model to test the in vivo efficacy of chemical chaperones.
  Journal of pharmacological and toxicological methods 1998 Bai C, Biwersi J, Verkman AS, Matthay MA
• Effects of ATP-sensitive potassium channel opener on potassium transport and alveolar fluid clearance in the resected human lung.
  Pharmacology & toxicology 1998 Sakuma T, Takahashi K, Ohya N, Nakada T, Matthay MA
• Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels.
  American journal of respiratory cell and molecular biology 1998 Ma T, Yang B, Matthay MA, Verkman AS
• New in situ mouse model to quantify alveolar epithelial fluid clearance.
  Journal of applied physiology (Bethesda, Md. : 1985) 1998 Garat C, Carter EP, Matthay MA
• High microvascular endothelial water permeability in mouse lung measured by a pleural surface fluorescence method.
  Biophysical journal 1998 Carter EP, Olveczky BP, Matthay MA, Verkman AS
• The American-European Consensus Conference on ARDS, part 2. Ventilatory, pharmacologic, supportive therapy, study design strategies and issues related to recovery and remodeling.
  Intensive care medicine 1998 Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM
• The American-European Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome.
  American journal of respiratory and critical care medicine 1998 Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM
• Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Dobbs LG, Gonzalez R, Matthay MA, Carter EP, Allen L, Verkman AS
• Just say NO to inhaled nitric oxide for the acute respiratory distress syndrome.
  Critical care medicine 1998 Matthay MA, Pittet JF, Jayr C
• Developmental changes in water permeability across the alveolar barrier in perinatal rabbit lung.
  The Journal of clinical investigation 1997 Carter EP, Umenishi F, Matthay MA, Verkman AS
• Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance.
  American journal of respiratory and critical care medicine 1997 Chesnutt AN, Matthay MA, Tibayan FA, Clark JG
• Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation.
  American journal of respiratory and critical care medicine 1997 Tibayan FA, Chesnutt AN, Folkesson HG, Eandi J, Matthay MA
• Upregulation of alveolar liquid clearance after fluid resuscitation for hemorrhagic shock in rats.
  The American journal of physiology 1997 Modelska K, Matthay MA, McElroy MC, Pittet JF
• Inhibition of CD18 or CD11b attenuates acute lung injury after acid instillation in rabbits.
  Journal of applied physiology (Bethesda, Md. : 1985) 1997 Folkesson HG, Matthay MA
• Noninvasive positive pressure ventilation for acute respiratory failure: underutilized or overrated?
  Chest 1997 Jasmer RM, Luce JM, Matthay MA
• Alveolar epithelial fluid clearance mechanisms are intact after moderate hyperoxic lung injury in rats.
  Chest 1997 Garat C, Meignan M, Matthay MA, Luo DF, Jayr C
• Evidence for a hydrostatic mechanism in human neurogenic pulmonary edema.
  Chest 1997 Smith WS, Matthay MA
• Protein tyrosine phosphatases mediate cell readhesion in alveolar epithelial cells mechanically separated from in vitro matrix.
  American journal of respiratory cell and molecular biology 1997 Oliver BL, Garat C, Pytela R, Matthay MA
• Biological markers of acute lung injury: prognostic and pathogenetic significance.
  American journal of respiratory and critical care medicine 1997 Pittet JF, Mackersie RC, Martin TR, Matthay MA
• Soluble transforming growth factor-alpha is present in the pulmonary edema fluid of patients with acute lung injury.
  Chest 1997 Chesnutt AN, Kheradmand F, Folkesson HG, Alberts M, Matthay MA
• Beta-adrenergic agonist stimulated alveolar fluid clearance in ex vivo human and rat lungs.
  American journal of respiratory and critical care medicine 1997 Sakuma T, Folkesson HG, Suzuki S, Okaniwa G, Fujimura S, Matthay MA
• Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-alpha-dependent mechanism.
  The Journal of clinical investigation 1997 Rezaiguia S, Garat C, Delclaux C, Meignan M, Fleury J, Legrand P, Matthay MA, Jayr C
• Increased alveolar fluid clearance following thoracotomy: report of a case and results of an analysis.
  Surgery today 1997 Sakuma T, Usuda K, Handa M, Okaniwa G, Nakada T, Fujimura S, Matthay MA
• Sharp increase in rat lung water channel expression in the perinatal period.
  American journal of respiratory cell and molecular biology 1996 Umenishi F, Carter EP, Yang B, Oliver B, Matthay MA, Verkman AS
• Soluble and insoluble fibronectin increases alveolar epithelial wound healing in vitro.
  The American journal of physiology 1996 Garat C, Kheradmand F, Albertine KH, Folkesson HG, Matthay MA
• Anti-IL-8 autoantibodies in alveolar fluid from patients with the adult respiratory distress syndrome.
  Journal of immunology (Baltimore, Md. : 1950) 1996 Kurdowska A, Miller EJ, Noble JM, Baughman RP, Matthay MA, Brelsford WG, Cohen AB
• Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis.
  Critical care medicine 1996 Miller EJ, Cohen AB, Matthay MA
• Transalveolar osmotic and diffusional water permeability in intact mouse lung measured by a novel surface fluorescence method.
  The Journal of general physiology 1996 Carter EP, Matthay MA, Farinas J, Verkman AS
• Acid aspiration induced lung injury. New insights and therapeutic options.
  American journal of respiratory and critical care medicine 1996 Matthay MA, Rosen GD
• Alveolar liquid clearance is increased by endogenous catecholamines in hemorrhagic shock in rats.
  Journal of applied physiology (Bethesda, Md. : 1985) 1996 Pittet JF, Brenner TJ, Modelska K, Matthay MA
• Transforming growth factor-alpha increases alveolar liquid clearance in anesthetized ventilated rats.
  The American journal of physiology 1996 Folkesson HG, Pittet JF, Nitenberg G, Matthay MA
• The acute respiratory distress syndrome.
  The New England journal of medicine 1996 Matthay MA
• Alveolar epithelial clearance of protein.
  Journal of applied physiology (Bethesda, Md. : 1985) 1996 Folkesson HG, Matthay MA, Weström BR, Kim KJ, Karlsson BW, Hastings RH
• Preservation of alveolar epithelial fluid transport mechanisms in rewarmed human lung after severe hypothermia.
  Journal of applied physiology (Bethesda, Md. : 1985) 1996 Sakuma T, Suzuki S, Usuda K, Handa M, Okaniwa G, Nakada T, Fujimura S, Matthay MA
• Pulmonary edema in a woman following fetal surgery.
  Chest 1996 DiFederico EM, Harrison M, Matthay MA
• Salt and water transport across alveolar and distal airway epithelia in the adult lung.
  The American journal of physiology 1996 Matthay MA, Folkesson HG, Verkman AS
• Transepithelial water permeability in microperfused distal airways. Evidence for channel-mediated water transport.
  The Journal of clinical investigation 1996 Folkesson HG, Matthay MA, Frigeri A, Verkman AS
• Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.
  The Journal of experimental medicine 1996 Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM
• Alveolar endotoxin increases alveolar liquid clearance in rats.
  Journal of applied physiology (Bethesda, Md. : 1985) 1995 Garat C, Rezaiguia S, Meignan M, D'Ortho MP, Harf A, Matthay MA, Jayr C
• Identification of patients with acute lung injury. Predictors of mortality.
  American journal of respiratory and critical care medicine 1995 Doyle RL, Szaflarski N, Modin GW, Wiener-Kronish JP, Matthay MA
• Cellular uptake of albumin from lungs of anesthetized rabbits.
  The American journal of physiology 1995 Hastings RH, Folkesson HG, Petersen V, Ciriales R, Matthay MA
• Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms.
  The Journal of clinical investigation 1995 Folkesson HG, Matthay MA, Hébert CA, Broaddus VC
• Evaluation of definitions of ARDS.
  American journal of respiratory and critical care medicine 1995 Rubenfeld GD, Doyle RL, Matthay MA
• Resistance of the alveolar epithelium to injury from septic shock in sheep.
  American journal of respiratory and critical care medicine 1995 Pittet JF, Wiener-Kronish JP, Serikov V, Matthay MA
• Death and other complications of emergency airway management in critically ill adults. A prospective investigation of 297 tracheal intubations.
  Anesthesiology 1995 Schwartz DE, Matthay MA, Cohen NH
• Frequency and importance of barotrauma in 100 patients with acute lung injury.
  Critical care medicine 1995 Schnapp LM, Chin DP, Szaflarski N, Matthay MA
• Fibrosing alveolitis in the adult respiratory distress syndrome.
  Annals of internal medicine 1995 Matthay MA
• The effect of salt water on alveolar epithelial barrier function.
  American journal of respiratory and critical care medicine 1994 Folkesson HG, Kheradmand F, Matthay MA
• Transforming growth factor-alpha enhances alveolar epithelial cell repair in a new in vitro model.
  The American journal of physiology 1994 Kheradmand F, Folkesson HG, Shum L, Derynk R, Pytela R, Matthay MA
• Alveolar fluid clearance in the resected human lung.
  American journal of respiratory and critical care medicine 1994 Sakuma T, Okaniwa G, Nakada T, Nishimura T, Fujimura S, Matthay MA
• Stimulation of lung epithelial liquid clearance by endogenous release of catecholamines in septic shock in anesthetized rats.
  The Journal of clinical investigation 1994 Pittet JF, Wiener-Kronish JP, McElroy MC, Folkesson HG, Matthay MA
• Alveolar liquid and protein clearance in anesthetized ventilated rats.
  Journal of applied physiology (Bethesda, Md. : 1985) 1994 Jayr C, Garat C, Meignan M, Pittet JF, Zelter M, Matthay MA
• Transcellular water transport in lung alveolar epithelium through mercury-sensitive water channels.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Folkesson HG, Matthay MA, Hasegawa H, Kheradmand F, Verkman AS
• Effect of endocytosis inhibitors on alveolar clearance of albumin, immunoglobulin G, and SP-A in rabbits.
  The American journal of physiology 1994 Hastings RH, Wright JR, Albertine KH, Ciriales R, Matthay MA
• Function of the alveolar epithelial barrier under pathologic conditions.
  Chest 1994 Matthay MA
• Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues.
  The Journal of biological chemistry 1994 Hasegawa H, Ma T, Skach W, Matthay MA, Verkman AS
• Prevalence and severity of neurologic dysfunction in critically ill patients. Influence on need for continued mechanical ventilation.
  Chest 1993 Kelly BJ, Matthay MA
• Alveolar epithelial barrier and acute lung injury.
  New horizons (Baltimore, Md.) 1993 Matthay MA, Folkesson HG, Campagna A, Kheradmand F
• Transient effect of epidermal growth factor on the motility of an immortalized mammary epithelial cell line.
  Journal of cell science 1993 Matthay MA, Thiery JP, Lafont F, Stampfer F, Boyer B
• Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits.
  Journal of applied physiology (Bethesda, Md. : 1985) 1993 Wiener-Kronish JP, Sakuma T, Kudoh I, Pittet JF, Frank D, Dobbs L, Vasil ML, Matthay MA
• Pseudomonas aeruginosa-induced lung and pleural injury in sheep. Differential protective effect of circulating versus alveolar immunoglobulin G antibody.
  The Journal of clinical investigation 1993 Pittet JF, Matthay MA, Pier G, Grady M, Wiener-Kronish JP
• Effect of temperature on alveolar liquid and protein clearance in an in situ perfused goat lung.
  Journal of applied physiology (Bethesda, Md. : 1985) 1993 Serikov VB, Grady M, Matthay MA
• Neutrophil-activating peptide-2 in patients with pulmonary edema from congestive heart failure or ARDS.
  The American journal of physiology 1993 Cohen AB, Stevens MD, Miller EJ, Atkinson MA, Mullenbach G, Maunder RJ, Martin TR, Wiener-Kronish JP, Matthay MA
• Preoperative and intraoperative factors associated with prolonged mechanical ventilation. A study in patients following major abdominal vascular surgery.
  Chest 1993 Jayr C, Matthay MA, Goldstone J, Gold WM, Wiener-Kronish JP
• Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock.
  Journal of immunology (Baltimore, Md. : 1950) 1993 Newman W, Beall LD, Carson CW, Hunder GG, Graben N, Randhawa ZI, Gopal TV, Wiener-Kronish J, Matthay MA
• Alveolar liquid and protein clearance in the absence of blood flow or ventilation in sheep.
  Journal of applied physiology (Bethesda, Md. : 1985) 1993 Sakuma T, Pittet JF, Jayr C, Matthay MA
• Clearance of different-sized proteins from the alveolar space in humans and rabbits.
  Journal of applied physiology (Bethesda, Md. : 1985) 1992 Hastings RH, Grady M, Sakuma T, Matthay MA
• Neuropeptides in pulmonary edema fluid of adult respiratory distress syndrome.
  Inflammation 1992 Espiritu RF, Pittet JF, Matthay MA, Goetzl EJ
• Pulmonary edema associated with salt water near-drowning: new insights.
  The American review of respiratory disease 1992 Cohen DS, Matthay MA, Cogan MG, Murray JF
• Persistent paralysis in critically ill patients after long-term administration of vecuronium.
  The New England journal of medicine 1992 Segredo V, Caldwell JE, Matthay MA, Sharma ML, Gruenke LD, Miller RD
• Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality.
  The American review of respiratory disease 1992 Miller EJ, Cohen AB, Nagao S, Griffith D, Maunder RJ, Martin TR, Weiner-Kronish JP, Sticherling M, Christophers E, Matthay MA
• Obstetric patients requiring critical care. A five-year review.
  Chest 1992 Kilpatrick SJ, Matthay MA
• Effect of epinephrine on the ability of end-tidal carbon dioxide readings to predict initial resuscitation from cardiac arrest.
  Critical care medicine 1992 Callaham M, Barton C, Matthay M
• Alveolar and lung liquid clearance in the absence of pulmonary blood flow in sheep.
  Journal of applied physiology (Bethesda, Md. : 1985) 1991 Jayr C, Matthay MA
• Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin.
  The Journal of clinical investigation 1991 Wiener-Kronish JP, Albertine KH, Matthay MA
• Critical care medicine.
  JAMA 1991 Matthay MA, Matthay RA
• Alveolar and lung liquid clearance in anesthetized rabbits.
  Journal of applied physiology (Bethesda, Md. : 1985) 1991 Smedira N, Gates L, Hastings R, Jayr C, Sakuma T, Pittet JF, Matthay MA
• Resolution of pulmonary edema. New insights.
  The Western journal of medicine 1991 Matthay MA
• Right-heart catheterization is a diagnostic procedure not a therapeutic intervention.
  Journal of intensive care medicine 1991 Chatterjee K, Matthay M
• Intact epithelial barrier function is critical for the resolution of alveolar edema in humans.
  The American review of respiratory disease 1990 Matthay MA, Wiener-Kronish JP
• Pulmonary endothelial cell injury and altered lung metabolic function. Early detection of the adult respiratory distress syndrome and possible functional significance.
  Clinics in chest medicine 1990 Wiedemann HP, Matthay MA, Gillis CN
• The adult respiratory distress syndrome. Definition and prognosis.
  Clinics in chest medicine 1990 Matthay MA
• Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome.
  The Journal of clinical investigation 1990 Rubin DB, Wiener-Kronish JP, Murray JF, Green DR, Turner J, Luce JM, Montgomery AB, Marks JD, Matthay MA
• The adult respiratory distress syndrome: definition and prognosis, pathogenesis and treatment.
  British journal of anaesthesia 1990 Wiener-Kronish JP, Gropper MA, Matthay MA
• Comparison of transesophageal echocardiographic and scintigraphic estimates of left ventricular end-diastolic volume index and ejection fraction in patients following coronary artery bypass grafting.
  Anesthesiology 1990 Urbanowicz JH, Shaaban MJ, Cohen NH, Cahalan MK, Botvinick EH, Chatterjee K, Schiller NB, Dae MW, Matthay MA
• The case for oxidants in the adult respiratory distress syndrome--"elementary, Dr. Watson".
  The Journal of laboratory and clinical medicine 1990 Heffner JE, Matthay MA
• Prolonged neuromuscular blockade after long-term administration of vecuronium in two critically ill patients.
  Anesthesiology 1990 Segredo V, Matthay MA, Sharma ML, Gruenke LD, Caldwell JE, Miller RD
• Pulmonary manifestations of endocrine and metabolic disorders.
  Clinics in chest medicine 1989 Brüssel T, Matthay MA, Chernow B
• Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability.
  The Journal of clinical investigation 1989 Martin TR, Pistorese BP, Chi EY, Goodman RB, Matthay MA
• Protein clearance from the air spaces and lungs of unanesthetized sheep over 144 h.
  Journal of applied physiology (Bethesda, Md. : 1985) 1989 Berthiaume Y, Albertine KH, Grady M, Fick G, Matthay MA
• New modes of mechanical ventilation for ARDS. How should they be evaluated?
  Chest 1989 Matthay MA
• Ureteral obstruction caused by vasculitis.
  The Journal of urology 1989 Baskin L, Mee S, Matthay M, Carroll PR
• Respiratory management after cardiac surgery.
  Chest 1989 Matthay MA, Wiener-Kronish JP
• The adult respiratory distress syndrome. New insights into diagnosis, pathophysiology, and treatment.
  The Western journal of medicine 1989 Matthay MA
• Fate of aerosolized recombinant DNA-produced alpha 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance.
  Proceedings of the National Academy of Sciences of the United States of America 1989 Hubbard RC, Casolaro MA, Mitchell M, Sellers SE, Arabia F, Matthay MA, Crystal RG
• Bedside catheterization of the pulmonary artery: risks compared with benefits.
  Annals of internal medicine 1988 Matthay MA, Chatterjee K
• Relationship of pleural effusions to increased permeability pulmonary edema in anesthetized sheep.
  The Journal of clinical investigation 1988 Wiener-Kronish JP, Broaddus VC, Albertine KH, Gropper MA, Matthay MA, Staub NC
• An expanded definition of the adult respiratory distress syndrome.
  The American review of respiratory disease 1988 Murray JF, Matthay MA, Luce JM, Flick MR
• Alveolar liquid and protein clearance from normal dog lungs.
  Journal of applied physiology (Bethesda, Md. : 1985) 1988 Berthiaume Y, Broaddus VC, Gropper MA, Tanita T, Matthay MA
• Hydrostatic versus increased permeability pulmonary edema: diagnosis based on radiographic criteria in critically ill patients.
  Radiology 1988 Aberle DR, Wiener-Kronish JP, Webb WR, Matthay MA
• Sulfidopeptide-leukotriene peptidases in pulmonary edema fluid from patients with the adult respiratory distress syndrome.
  Journal of clinical immunology 1988 Ratnoff WD, Matthay MA, Wong MY, Ito Y, Vu KH, Wiener-Kronish J, Goetzl EJ
• Pleural effusions associated with hydrostatic and increased permeability pulmonary edema.
  Chest 1988 Wiener-Kronish JP, Matthay MA
• Lack of association of pleural effusion with chronic pulmonary arterial and right atrial hypertension.
  Chest 1987 Wiener-Kronish JP, Goldstein R, Matthay RA, Biondi JW, Broaddus VC, Chatterjee K, Matthay MA
• Adult respiratory distress syndrome related to antilymphocyte globulin therapy.
  Chest 1987 Dean NC, Amend WC, Matthay MA
• Beta-adrenergic agonists increase lung liquid clearance in anesthetized sheep.
  The Journal of clinical investigation 1987 Berthiaume Y, Staub NC, Matthay MA
• The adult respiratory distress syndrome.
  The Yale journal of biology and medicine 1986 Biondi JW, Hines RL, Barash PG, Baker CC, Matthay MA, Matthay RA
• Helium-oxygen gas therapy. Use and availability for the emergency treatment of inoperable airway obstruction.
  Chest 1986 Curtis JL, Mahlmeister M, Fink JB, Lampe G, Matthay MA, Stulbarg MS
• Central intravascular pressure measurements: when should we believe them?
  Journal of thoracic imaging 1986 Gates LM, Matthay MA
• Pathophysiology of the adult respiratory distress syndrome. What have we learned from human studies?
  Critical care clinics 1986 Fein A, Wiener-Kronish JP, Niederman M, Matthay MA
• Poor correlation between pulmonary arterial wedge pressure and left ventricular end-diastolic volume after coronary artery bypass graft surgery.
  Anesthesiology 1986 Hansen RM, Viquerat CE, Matthay MA, Wiener-Kronish JP, DeMarco T, Bahtia S, Marks JD, Botvinick EH, Chatterjee K
• Clinical spectrum of pulmonary mucormycosis.
  Chest 1986 Bigby TD, Serota ML, Tierney LM, Matthay MA
• Leukotrienes in pulmonary edema fluid after cardiopulmonary bypass.
  Anesthesia and analgesia 1986 Swerdlow BN, Mihm FG, Goetzl EJ, Matthay MA
• Pulmonary embolism. Guide to diagnosis, treatment, and prevention.
  Postgraduate medicine 1986 Broaddus C, Matthay MA
• Intensive care unit: how stressful for physicians?
  Critical care medicine 1986 Eisendrath SJ, Link N, Matthay M
• Relationship of pleural effusions to pulmonary hemodynamics in patients with congestive heart failure.
  The American review of respiratory disease 1985 Wiener-Kronish JP, Matthay MA, Callen PW, Filly RA, Gamsu G, Staub NC
• Cellular basis for injury and repair in the adult respiratory distress syndrome.
  The Western journal of medicine 1985 Matthay MA
• Long-term clearance of liquid and protein from the lungs of unanesthetized sheep.
  Journal of applied physiology (Bethesda, Md. : 1985) 1985 Matthay MA, Berthiaume Y, Staub NC
• Pathophysiology of pulmonary edema.
  Clinics in chest medicine 1985 Matthay MA
• Resolution of pulmonary edema. Mechanisms of liquid, protein, and cellular clearance from the lung.
  Clinics in chest medicine 1985 Matthay MA
• Undrained bloody pericardial effusion in the early postoperative period after coronary bypass surgery: a prospective blood pool study.
  American heart journal 1985 Viquerat CE, Hansen RM, Botvinick EH, Dae MW, Wiener-Kronish JP, Matthay MA
• Biologically active products of complement and acute lung injury in patients with the sepsis syndrome.
  The American review of respiratory disease 1984 Weinberg PF, Matthay MA, Webster RO, Roskos KV, Goldstein IM, Murray JF
• Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome.
  Journal of clinical immunology 1984 Matthay MA, Eschenbacher WL, Goetzl EJ
• Neurogenic pulmonary edema.
  The American review of respiratory disease 1984 Colice GL, Matthay MA, Bass E, Matthay RA
• Morphologic and physiologic correlates of increased extravascular lung water.
  Surgery 1984 Bongard FS, Matthay M, Mackersie RC, Lewis FR
• Cardiovascular-pulmonary monitoring in the intensive care unit (Part 2).
  Chest 1984 Wiedemann HP, Matthay MA, Matthay RA
• Cardiovascular-pulmonary monitoring in the intensive care unit (Part 1).
  Chest 1984 Wiedemann HP, Matthay MA, Matthay RA
• Guillain-Barré syndrome: psychosocial aspects of management.
  Psychosomatics 1983 Eisendrath SJ, Matthay MA, Dunkel JA, Zimmerman JK, Layzer RB
• Hemodynamic management in the adult respiratory distress syndrome.
  Clinics in chest medicine 1983 Prewitt RM, Matthay MA, Ghignone M
• Invasive hemodynamic monitoring in critically ill patients.
  Clinics in chest medicine 1983 Matthay MA
• Overperfusion, hypoxia, and increased pressure cause only hydrostatic pulmonary edema in anesthetized sheep.
  Circulation research 1983 Landolt CC, Matthay MA, Albertine KH, Roos PJ, Wiener-Kronish JP, Staub NC
• Differential liquid and protein clearance from the alveoli of anesthetized sheep.
  Journal of applied physiology: respiratory, environmental and exercise physiology 1982 Matthay MA, Landolt CC, Staub NC
• Adult respiratory distress syndrome complicating diabetic ketoacidosis.
  The Western journal of medicine 1981 Russell J, Follansbee S, Matthay M
• Anatomic variations of efferent duct from caudal mediastinal lymph node in sheep.
  Journal of applied physiology: respiratory, environmental and exercise physiology 1981 Landolt CC, Matthay MA, Staub NC
• Chest mass with pleurisy.
  Chest 1979 Matthay MA, Addison TE, Ellinger G, Choy SH, Kaltreider HB
• Thyrotoxicosis: comparison of effects of thyroid ablation and beta-adrenergic blockade on metabolic rate and ventilatory control.
  The Journal of clinical endocrinology and metabolism 1978 Zwillich CW, Matthay M, Potts DE, Adler R, Hofeldt F, Weil JV
• Acute pseudogout in the absence of synovial fluid Leukocytes.
  The Journal of rheumatology 1977 Matthay M, Lindamood M, Steigerwald JC, Solomons C
• Hypertrophic osteoarthropathy in adults with cystic fibrosis.
  Thorax 1976 Matthay MA, Matthay RA, Mills DM, Lakshminarayan S, Cotton E
• Grand mal seizure induced by oral theophylline.
  Thorax 1976 Matthay RA, Matthay MA, Weinberger MM