Michael Mann, MD
Professor
Surgery
School of Medicine

Mann's research interests include developing molecular therapies – treatments that target specific cells involved in disease – for disorders of the heart and lungs. While on the faculty at Harvard Medical School, he designed and directed the first clinical program for genetic manipulation during bypass surgery.

Mann earned his medical degree at the Stanford University School of Medicine. He completed a residency at Stanford Medicine and Brigham and Women's Hospital in Boston, followed by a fellowship at UCSF.

• Resectability, Recurrence, and Risk Stratification of Giant Solitary Fibrous Tumors in the Thoracic Cavity.
  Annals of surgical oncology 2021 Woodard GA, Fels Elliott DR, Yap A, Haro GJ, Kratz JR, Mann MJ, Jones KD, Jablons DM
• MO01.13 Molecular Risk Stratification is Independent of EGFR Mutation Status in Identifying Early Stage Non-Squamous Non-Small Cell Lung Cancer Patients at Risk for Recurrence and Likely to Benefit from Adjuvant Chemotherapy.
  Journal of Thoracic Oncology 2021 G. Woodard, J. Kratz, G. Haro, M. Gubens, C. Blakely, K. Jones, M. Mann, D. Jablons
• Comparison of Conventional TNM and Novel TNMB Staging Systems for Non-Small Cell Lung Cancer.
  JAMA network open 2019 Haro GJ, Sheu B, Cook NR, Woodard GA, Mann MJ, Kratz JR
• MA06.09 Timing of Driver Mutation Development and the Genetic Evolution of Semi-Solid Lung Nodules into Early NSCLC.
  Journal of Thoracic Oncology 2019 G. Woodard, V. Ding, I. Kim, K. Jones, G. Chavez, G. Haro, J. Kratz, M. Mann, J. Rotow, C. Blakely, D. Jablons
• Differential gene expression identifies KRT7 and MUC1 as potential metastasis-specific targets in sarcoma.
  Cancer management and research 2019 Jiang L, Tolani B, Yeh CC, Fan Y, Reza JA, Horvai AE, Xia E, Kratz JR, Jablons DM, Mann MJ
• Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer Staging.
  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2019 Kratz JR, Haro GJ, Cook NR, He J, Van Den Eeden SK, Woodard GA, Gubens MA, Jahan TM, Jones KD, Kim IJ, He B, Jablons DM, Mann MJ
• P2.16-12 Expanded Data Confirm Molecular Testing Identifies Lung Adenocarcinoma Patients, Including Stage IA, Who Benefit from Adjuvant Chemotherapy.
  Journal of Thoracic Oncology 2018 G. Woodard, S. Wang, J. Kratz, G. Haro, M. Gubens, C. Blakely, T. Jahan, K. Jones, M. Mann, D. Jablons
• P3.03-24 Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer Staging.
  Journal of Thoracic Oncology 2018 G. Haro, J. Kratz, N. Cook, J. He, S. Van Den Eeden, G. Woodard, M. Gubens, T. Jahan, K. Jones, I. Kim, B. He, D. Jablons, M. Mann
• Propensity Matched Analysis of Perioperative Outcomes in Robotic-Assisted Thoracic Surgery, Video Assisted Thoracic Surgery, and Open Lung Resections.
  Journal of the American College of Surgeons 2018 Greg J. Haro, Johannes R. Kratz, David M. Jablons, Michael J. Mann, Jasleen Kukreja
• A review of soft-tissue sarcomas: translation of biological advances into treatment measures.
  Cancer management and research 2018 Hoang NT, Acevedo LA, Mann MJ, Tolani B
• Shift toward greater pathologic post-myocardial infarction remodeling with loss of the adaptive hypertrophic signaling of alpha1 adrenergic receptors in mice.
  PloS one 2017 Yeh CC, Fan Y, Xu Y, Yang YL, Simpson PC, Mann MJ
• Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect.
  Journal of biomedical science 2017 Yeh CC, Fan Y, Yang YL, Mann MJ
• Adjuvant Chemotherapy Guided by Molecular Profiling and Improved Outcomes in Early Stage, Non-Small-Cell Lung Cancer.
  Clinical lung cancer 2017 Woodard GA, Wang SX, Kratz JR, Zoon-Besselink CT, Chiang CY, Gubens MA, Jahan TM, Blakely CM, Jones KD, Mann MJ, Jablons DM
• OA19.06 Adjuvant Chemotherapy Decisions Based on Molecular Risk Status Improves Outcomes in Early Stage, Non-Small Cell Lung Cancer.
  Journal of Thoracic Oncology 2017 Gavitt Woodard, Jane Crockard, Clara Zoon-Besselink, Johannes Kratz, Matthew Gubens, Thierry Jahan, Collin Blakely, Kirk Jones, Michael Mann, David Jablons
• P1.03-066 Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer TNM Staging Topic: Staging.
  Journal of Thoracic Oncology 2017 Johannes Kratz, Nancy Cook, Gavitt Woodard, Kirk Jones, Matthew Gubens, Thierry Jahan, Il-Jin Kim, Biao He, David Jablons, Michael Mann
• Spacial and Temporal Patterns of Gene Expression After Cardiac MEK1 Gene Transfer Improve Post-Infarction Remodeling Without Inducing Global Hypertrophy.
  Journal of cellular biochemistry 2016 Fan Y, Yang YL, Yeh CC, Mann MJ
• Genistein Suppresses Growth of Human Uterine Sarcoma Cell Lines via Multiple Mechanisms.
  Anticancer research 2015 Yeh CC, Fan Y, Jiang L, Yang YL, He B, You L, Mann M
• Prognostic molecular assay might improve identification of patients at risk for recurrence in early-stage non-small-cell lung cancer.
  Clinical lung cancer 2014 Woodard GA, Gubens MA, Jahan TM, Jones KD, Kukreja J, Theodore PR, Cardozo S, Jew G, Clary-Macy C, Jablons DM, Mann MJ
• Aggressive and minimally invasive surgery for pulmonary metastasis of sarcoma.
  The Journal of thoracic and cardiovascular surgery 2014 Reza J, Sammann A, Jin C, Horvai A, Hudnall M, Jablons DM, Jahan T, Kornak J, Mann MJ
• VATS lobectomy facilitates the delivery of adjuvant docetaxel-carboplatin chemotherapy in patients with non-small cell lung cancer.
  Journal of thoracic disease 2013 Zhi X, Gao W, Han B, Yang Y, Li H, Liu D, Wang C, Min G, Long H, Rigas JR, Carey M, Jahan T, Sammann A, Reza J, Wang D, Mann MJ, Jablons DM, He J, China Clinical Trials Consortium
• Novel video-assisted thoracoscopic surgery metastatectomy technique equivalent to open thoracotomy for identification of numerous and small lesions.
  Journal of the American College of Surgeons 2013 Joseph A. Reza, Matthew Hudnall, Amanda Sammann, David M. Jablons, Michael J. Mann
• Analytical validation of a practical molecular assay prognostic of survival in nonsquamous non-small cell lung cancer.
  Diagnostic molecular pathology : the American journal of surgical pathology, part B 2013 Kratz JR, Tham PT, Mulvihill MS, Ziaei F, Ray MR, Hurst JW, Segal MR, Berryman DM, Chu W, He B, Jablons DM, Mann MJ
• International trial of adjuvant therapy in high risk stage I non-squamous cell carcinoma identified by a 14-gene prognostic signature.
  Translational lung cancer research 2013 Kratz JR, Mann MJ, Jablons DM
• Impact of a multigene prognostic assay on postoperative management of early-stage non-small cell lung cancer.
  Journal of Clinical Oncology 2013 Shane Dormady, Thierry Jahan, Michael J. Mann, David Jablons, Michael S. Broder, Alison H. DeCristofaro, Ayanna Anene
• Prognostic assay in small, node-negative non-small cell lung cancer--reply.
  JAMA 2013 Mann MJ, Jablons DM, Kratz JR
• MEK1-induced physiological hypertrophy inhibits chronic post-myocardial infarction remodeling in mice.
  Journal of cellular biochemistry 2013 Yeh CC, Malhotra D, Yang YL, Xu Y, Fan Y, Li H, Mann MJ
• A prognostic assay to identify patients at high risk of mortality despite small, node-negative lung tumors.
  JAMA 2012 Kratz JR, Van den Eeden SK, He J, Jablons DM, Mann MJ
• Pulmonary metastasectomy: Improving survival with less invasive, more aggressive surgery.
  Journal of the American College of Surgeons 2012 Joseph A. Reza, Amanda Sammann, Barbara Grimes, Michael J. Mann
• A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies.
  Lancet (London, England) 2012 Kratz JR, He J, Van Den Eeden SK, Zhu ZH, Gao W, Pham PT, Mulvihill MS, Ziaei F, Zhang H, Su B, Zhi X, Quesenberry CP, Habel LA, Deng Q, Wang Z, Zhou J, Li H, Huang MC, Yeh CC, Segal MR, Ray MR, Jones…
• IL11 is prognostic of survival in lung adenocarcinoma.
  Journal of the American College of Surgeons 2011 Johannes R. Kratz, Patrick T. Pham, Michael S. Mulvihill, M. Roshni Ray, Michael J. Mann, David M. Jablons
• Stem Cell Transplantation to the Heart.
  2010 Michael J. Mann
• Biomimetic matrices for myocardial stabilization and stem cell transplantation.
  Journal of biomedical materials research. Part A 2010 Wall ST, Yeh CC, Tu RY, Mann MJ, Healy KE
• Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse.
  Journal of cellular biochemistry 2010 Yeh CC, Li H, Malhotra D, Turcato S, Nicholas S, Tu R, Zhu BQ, Cha J, Swigart PM, Myagmar BE, Baker AJ, Simpson PC, Mann MJ
• Heart Failure Switches RV Inotropic Responses from Negative to Positive.
  Biophysical Journal 2010 Guanying Wang, Che-Chung Yeh, Brian C. Jensen, Michael J. Mann, Paul C. Simpson, Anthony J. Baker
• Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive.
  American journal of physiology. Heart and circulatory physiology 2009 Wang GY, Yeh CC, Jensen BC, Mann MJ, Simpson PC, Baker AJ
• Myocardial survival signaling in response to stem cell transplantation.
  Journal of the American College of Surgeons 2009 Li H, Malhotra D, Yeh CC, Tu R, Zhu BQ, Birger N, Wisneski A, Cha J, Karliner JS, Mann MJ
• Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction.
  American journal of physiology. Heart and circulatory physiology 2009 Yeh CC, Li H, Malhotra D, Huang MC, Zhu BQ, Goetzl EJ, Vessey DA, Karliner JS, Mann MJ
• Surgical ventricular reconstruction in mice: elucidating potential targets for combined molecular/surgical intervention.
  The Journal of thoracic and cardiovascular surgery 2009 Yeh CC, Malhotra D, Li H, Nicholas S, Tu R, Mann MJ
• Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease.
  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2008 Mahimkar R, Nguyen A, Mann M, Yeh CC, Zhu BQ, Karliner JS, Lovett DH
• National Institutes of Health funding for cardiothoracic surgical research.
  The Journal of thoracic and cardiovascular surgery 2008 Ratcliffe MB, Howard C, Mann M, del Nido P
• National institutes of health funding for surgical research.
  Annals of surgery 2008 Mann M, Tendulkar A, Birger N, Howard C, Ratcliffe MB
• Transcription factor decoys: a new model for disease intervention.
  Annals of the New York Academy of Sciences 2005 Mann MJ
• Use of bivalirudin, a direct thrombin inhibitor, and its reversal with modified ultrafiltration during heart transplantation in a patient with heparin-induced thrombocytopenia.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2005 Mann MJ, Tseng E, Ratcliffe M, Strattman G, De Silva A, Demarco T, Achorn N, Moskalik W, Hoopes C
• Reversal of direct thrombin inhibition after cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia.
  Anesthesia and analgesia 2004 Stratmann G, deSilva AM, Tseng EE, Hambleton J, Balea M, Romo AJ, Mann MJ, Achorn NL, Moskalik WF, Hoopes CW
• Cell cycle-dependent regulation of smooth muscle cell activation.
  Arteriosclerosis, thrombosis, and vascular biology 2004 Braun-Dullaeus RC, Mann MJ, Sedding DG, Sherwood SW, von der Leyen HE, Dzau VJ
• Isolated pulmonary arteriovenous malformations requiring anatomic resection.
  The Journal of thoracic and cardiovascular surgery 2004 Mann MJ, Kramer MJ, Hall TS, Anastassiou P, Katz J, Golden J, Jones K, Jablons DM
• Novel strategies for the prevention of bypass graft failure.
  BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2004 Mann MJ
• Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy.
  Circulation 2003 Griese DP, Ehsan A, Melo LG, Kong D, Zhang L, Mann MJ, Pratt RE, Mulligan RC, Dzau VJ
• Transcription factor decoys for the prevention of vein bypass graft failure.
  American journal of cardiovascular drugs : drugs, devices, and other interventions 2003 Mann MJ, Conte MS
• Molecular approaches for the treatment of atherosclerosis.
  Cardiology clinics 2002 Mann MJ, Dzau VJ
• Endothelial healing in vein grafts: proliferative burst unimpaired by genetic therapy of neointimal disease.
  Circulation 2002 Ehsan A, Mann MJ, Dell'Acqua G, Tamura K, Braun-Dullaeus R, Dzau VJ
• Experimental Models of Arteriovenous Grafting.
  2000 Afshin Ehsan, Michael J. Mann, Victor J. Dzau
• Gene Therapy in Cardiovascular Disease.
  2000 Victor J. Dzau, Afshin Ehsan, Michael J. Mann
• Vascular growth factors as an adjunct to surgical revascularization.
  ACC Current Journal Review 2000 Michael J Mann, Afshin Ehsan, Victor J Dzau
• DNA transfer into vascular smooth muscle using fusigenic Sendai virus (HJV)-liposomes.
  1997 Michael J. Mann, Ryuichi Morishita, Gary H. Gibbons, Heiko E. von der Leyen, Victor J. Dzau
• 901-90 In Vivo Genetic Engineering of Cardiac Cells: Intracoronary Administration of Antisense (AS) Oligonucleotides (ODN).
  Journal of the American College of Cardiology 1995 Kristin E. Ellison, Gary H. Gibbons, Ryuichi Morishita, Michael J. Mann, Robert S. Kernoff, Victor J. Dzau
• 914-71 High Efficiency Gene Transfer into Atherosclerotic Lesions in Hypercholesterolemic Rabbit Carotid Arteries.
  Journal of the American College of Cardiology 1995 Heiko E. von der Leyen, Michael J. Mann, Gary H. Gibbons, Victor J. Dzau