Michael Lesh, MD
Professor
Medicine
School of Medicine

Dr. Lesh’s research at UCSF led to the first AF pulmonary vein isolation(PVI) patent: 6,012,457 “Device and method for forming a circumferential conduction block at pulmonary vein.” Atrionix, founded to commercialize this innovation, was acquired by Biosense/Webster in 1999. Dr. Lesh was Founder, Chairman and CEO of Appriva Medical, which developed the first trans-catheter LAA occlusion device (PLAATO) to prevent stroke in patients with AF. The Appriva patents form the basis of the Watchman device. He was Founder, Chairman and CEO of Mitralife (acq. MDT), which developed a coronary sinus implant for MR and of Evera Medical, which fabricated biomaterials for reconstructive surgery. Dr. Lesh was Founder, Chairman and CEO of Middle Peak Medical (acquired, Symetis), which is developing a percutaneous mitral valve. Dr. Lesh was Independent Director at HeartScape (acq. by Roper) and Stentys (STNT, IPO 2011). He is currently Executive Director of several early-stage companies including Cordance (open BBB to treat CNS) and Abate Med (biotech for skin disease).

• An endovascular approach to cardioembolic stroke prevention in atrial fibrillation patients.
  Pacing and clinical electrophysiology : PACE 2003 Nakai T, Lesh M, Ostermayer S, Billinger K, Sievert H
• Percutaneous left atrial appendage occlusion (PLAATO) for preventing cardioembolism: first experience in canine model.
  Circulation 2002 Nakai T, Lesh MD, Gerstenfeld EP, Virmani R, Jones R, Lee RJ
• Percutaneous left atrial appendage transcatheter occlusion to prevent stroke in high-risk patients with atrial fibrillation: early clinical experience.
  Circulation 2002 Sievert H, Lesh MD, Trepels T, Omran H, Bartorelli A, Della Bella P, Nakai T, Reisman M, DiMario C, Block P, Kramer P, Fleschenberg D, Krumsdorf U, Scherer D
• Empirical pulmonary vein isolation in patients with chronic atrial fibrillation using a three-dimensional nonfluoroscopic mapping system: long-term follow-up.
  Pacing and clinical electrophysiology : PACE 2001 Kanagaratnam L, Tomassoni G, Schweikert R, Pavia S, Bash D, Beheiry S, Lesh M, Niebauer M, Saliba W, Chung M, Tchou P, Natale A
• Clinical outcome after radiofrequency catheter ablation of focal atrial fibrillation triggers.
  Journal of cardiovascular electrophysiology 2001 Gerstenfeld EP, Guerra P, Sparks PB, Hattori K, Lesh MD
• A classification of atrial flutter and regular atrial tachycardia according to electrophysiological mechanisms and anatomical bases; a Statement from a Joint Expert Group from The Working Group of Arrhythmias of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology.
  European heart journal 2001 Saoudi N, Cosío F, Waldo A, Chen SA, Iesaka Y, Lesh M, Saksena S, Salerno J, Schoels W, Working Group of Arrhythmias of the European of Cardiology and the North American Society of Pacing
• Classification of atrial flutter and regular atrial tachycardia according to electrophysiologic mechanism and anatomic bases: a statement from a joint expert group from the Working Group of Arrhythmias of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology.
  Journal of cardiovascular electrophysiology 2001 Saoudi N, Cosio F, Waldo A, Chen SA, Iesaka Y, Lesh M, Saksena S, Salerno J, Schoels W
• Electrocardiographic analysis of ectopic atrial activity obscured by ventricular repolarization: P wave isolation using an automatic 62-lead QRST subtraction algorithm.
  Journal of cardiovascular electrophysiology 2001 Sippensgroenewegen A, Mlynash MD, Roithinger FX, Goseki Y, Lesh MD
• Atypical right atrial flutter patterns.
  Circulation 2001 Yang Y, Cheng J, Bochoeyer A, Hamdan MH, Kowal RC, Page R, Lee RJ, Steiner PR, Saxon LA, Lesh MD, Modin GW, Scheinman MM
• Central clinical research issues in electrophysiology: report of the NASPE Committee.
  Pacing and clinical electrophysiology : PACE 2001 Domanski MJ, Zipes DP, Benditt DG, Camm AJ, Exner DV, Ezekowitz MD, Greene HL, Lesh MD, Miller JM, Pratt CM, Saksena S, Scheinman MM, Singh BN, Tracy CM, Waldo AL, North American Society of Pacing and…
• First human experience with pulmonary vein isolation using a through-the-balloon circumferential ultrasound ablation system for recurrent atrial fibrillation.
  Circulation 2000 Natale A, Pisano E, Shewchik J, Bash D, Fanelli R, Potenza D, Santarelli P, Schweikert R, White R, Saliba W, Kanagaratnam L, Tchou P, Lesh M
• Is there a role for biatrial pacing in the prevention of atrial arrhythmias?
  Journal of cardiovascular electrophysiology 2000 Gerstenfeld EP, Lesh MD
• Prevalence of the Brugada sign in idiopathic ventricular fibrillation and healthy controls.
  Heart (British Cardiac Society) 2000 Viskin S, Fish R, Eldar M, Zeltser D, Lesh MD, Glick A, Belhassen B
• The role of the crista terminalis in atrial flutter and fibrillation: a computer modeling study.
  Annals of biomedical engineering 2000 Ellis WS, SippensGroenewegen A, Auslander DM, Lesh MD
• Body surface mapping of counterclockwise and clockwise typical atrial flutter: a comparative analysis with endocardial activation sequence mapping.
  Journal of the American College of Cardiology 2000 SippensGroenewegen A, Lesh MD, Roithinger FX, Ellis WS, Steiner PR, Saxon LA, Lee RJ, Scheinman MM
• Heterogeneous sympathetic innervation influences local myocardial repolarization in normally perfused rabbit hearts.
  Circulation 2000 Yoshioka K, Gao DW, Chin M, Stillson C, Penades E, Lesh M, O'Connell W, Dae M
• Derivation of an optimal lead set for measuring ectopic atrial activation from the pulmonary veins by using body surface mapping.
  Journal of electrocardiology 2000 Gerstenfeld EP, SippensGroenewegen A, Lux RL, Lesh MD
• Novel catheter technology for ablative cure of atrial fibrillation.
  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2000 Lesh MD, Guerra P, Roithinger FX, Goseki Y, Diederich C, Nau WH, Maguire M, Taylor K
• Electrophysiologic effects of selective right versus left atrial linear lesions in a canine model of chronic atrial fibrillation.
  Journal of cardiovascular electrophysiology 1999 Roithinger FX, Steiner PR, Goseki Y, Sparks PB, Lesh MD
• The spatial dispersion of atrial refractoriness and atrial fibrillation vulnerability.
  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 1999 Roithinger FX, Karch MR, Steiner PR, SippensGroenewegen A, Lesh MD
• Use of electroanatomic mapping to delineate transseptal atrial conduction in humans.
  Circulation 1999 Roithinger FX, Cheng J, SippensGroenewegen A, Lee RJ, Saxon LA, Scheinman MM, Lesh MD
• An anatomic approach to prevention of atrial fibrillation: pulmonary vein isolation with through-the-balloon ultrasound ablation (TTB-USA).
  The Thoracic and cardiovascular surgeon 1999 Lesh MD, Diederich C, Guerra PG, Goseki Y, Sparks PB
• Catheter-ablative techniques for the treatment of atrial fibrillation.
  Current cardiology reports 1999 Guerra PG, Lesh MD
• Low-power radiofrequency application and intracardiac echocardiography for creation of continuous left atrial linear lesions.
  Journal of cardiovascular electrophysiology 1999 Roithinger FX, Steiner PR, Goseki Y, Liese KS, Scholtz DB, Sippensgroenewegen A, Ursell P, Lesh MD
• Autonomic nervous system tone measured by baroreflex sensitivity is depressed in patients with end-stage liver disease.
  The American journal of gastroenterology 1999 Barron HV, Alam I, Lesh MD, Strunk A, Bass NM
• What is the relationship of atrial flutter and fibrillation?
  Pacing and clinical electrophysiology : PACE 1999 Roithinger FX, Lesh MD
• Electrophysiologic effects of adenosine in patients with supraventricular tachycardia.
  Circulation 1999 Glatter KA, Cheng J, Dorostkar P, Modin G, Talwar S, Al-Nimri M, Lee RJ, Saxon LA, Lesh MD, Scheinman MM
• The role of nonpharmacologic therapies for the treatment of atrial fibrillation.
  Journal of cardiovascular electrophysiology 1999 Guerra PG, Lesh MD
• Use of intracardiac echocardiography during electrophysiologic evaluation and therapy of atrial arrhythmias.
  Journal of cardiovascular electrophysiology 1998 Lesh MD, Kalman JM, Karch MR
• Narrow complex tachycardia with VA block: diagnostic and therapeutic implications.
  Pacing and clinical electrophysiology : PACE 1998 Hamdan MH, Kalman JM, Lesh MD, Lee RJ, Saxon LA, Dorostkar P, Scheinman MM
• Organized activation during atrial fibrillation in man: endocardial and electrocardiographic manifestations.
  Journal of cardiovascular electrophysiology 1998 Roithinger FX, SippensGroenewegen A, Karch MR, Steiner PR, Ellis WS, Lesh MD
• Body surface mapping during pacing at multiple sites in the human atrium: P-wave morphology of ectopic right atrial activation.
  Circulation 1998 SippensGroenewegen A, Peeters HA, Jessurun ER, Linnenbank AC, Robles de Medina EO, Lesh MD, van Hemel NM
• "Cristal tachycardias": origin of right atrial tachycardias from the crista terminalis identified by intracardiac echocardiography.
  Journal of the American College of Cardiology 1998 Kalman JM, Olgin JE, Karch MR, Hamdan M, Lee RJ, Lesh MD
• Acute effects of intraoperative multisite ventricular pacing on left ventricular function and activation/contraction sequence in patients with depressed ventricular function.
  Journal of cardiovascular electrophysiology 1998 Saxon LA, Kerwin WF, Cahalan MK, Kalman JM, Olgin JE, Foster E, Schiller NB, Shinbane JS, Lesh MD, Merrick SH
• Anatomic and electrophysiologic relation between the coronary sinus and mitral annulus: implications for ablation of left-sided accessory pathways.
  American heart journal 1998 Shinbane JS, Lesh MD, Stevenson WG, Klitzner TS, Natterson PD, Wiener I, Ursell PC, Saxon LA
• Body surface mapping of atrial arrhythmias: atlas of paced P wave integral maps to localize the focal origin of right atrial tachycardia.
  Journal of electrocardiology 1998 SippensGroenewegen A, Roithinger FX, Peeters HA, Linnenbank AC, van Hemel NM, Steiner PR, Lesh MD
• Electrical mapping in combination with intracardiac ultrasound for electrical-anatomic correlation.
  Journal of electrocardiology 1998 Olgin JE, Lesh M, Kalman J
• Progress toward a catheter ablative cure of atrial fibrillation.
  Journal of electrocardiology 1998 Lesh MD
• Potential role of 'hybrid therapy' for atrial fibrillation.
  Seminars in interventional cardiology : SIIC 1997 Lesh MD, Kalman JM, Roithinger FX, Karch MR
• Relationship between atrial fibrillation and typical atrial flutter in humans: activation sequence changes during spontaneous conversion.
  Circulation 1997 Roithinger FX, Karch MR, Steiner PR, SippensGroenewegen A, Lesh MD
• The laboratory evaluation and role of catheter ablation for patients with atrial flutter.
  Cardiology clinics 1997 Olgin JE, Lesh MD
• Electrophysiological effects of long, linear atrial lesions placed under intracardiac ultrasound guidance.
  Circulation 1997 Olgin JE, Kalman JM, Chin M, Stillson C, Maguire M, Ursel P, Lesh MD
• Mode of onset of malignant ventricular arrhythmias in idiopathic ventricular fibrillation.
  Journal of cardiovascular electrophysiology 1997 Viskin S, Lesh MD, Eldar M, Fish R, Setbon I, Laniado S, Belhassen B
• Use of intracardiac echocardiography in interventional electrophysiology.
  Pacing and clinical electrophysiology : PACE 1997 Kalman JM, Olgin JE, Karch MR, Lesh MD
• Electrophysiology of "incisional" reentrant atrial tachycardia complicating surgery for congenital heart disease.
  Pacing and clinical electrophysiology : PACE 1997 Lesh MD, Kalman JM, Saxon LA, Dorostkar PC
• [Transcatheter subendocardial infusion: a novel technique for ablation of atrial arrhythmias].
  Herzschrittmachertherapie & Elektrophysiologie 1997 Goette A, Honeycutt C, Hartung W, Fleischman S, Swanson D, Lesh M, Langberg JJ
• P-wave morphology during right atrial pacing before and after atrial flutter ablation--a new marker for success.
  The American journal of cardiology 1997 Hamdan MH, Kalman JM, Barron HV, Lesh MD
• Mortality benefit of implantable cardioverter-defibrillator therapy in patients with persistent malignant ventricular arrhythmias despite amiodarone treatment.
  The American journal of cardiology 1997 Barron HV, Khan HH, Viskin S, Heller K, Kalman JM, Scheinman MM, Lesh MD
• Risk of thromboembolism in chronic atrial flutter.
  The American journal of cardiology 1997 Wood KA, Eisenberg SJ, Kalman JM, Drew BJ, Saxon LA, Lee RJ, Lesh MD, Scheinman MM
• Slow AV nodal pathway ablation utilizing a unique temperature controlled radiofrequency energy system.
  Pacing and clinical electrophysiology : PACE 1997 Epstein LM, Jung S, Lee RJ, Lesh MD, Eisenberg SJ, Scheinman MM, Fitzpatrick AP
• Electrocardiographic and electrophysiologic characterization of atypical atrial flutter in man: use of activation and entrainment mapping and implications for catheter ablation.
  Journal of cardiovascular electrophysiology 1997 Kalman JM, Olgin JE, Saxon LA, Lee RJ, Scheinman MM, Lesh MD
• Mechanism of initiation of atrial flutter in humans: site of unidirectional block and direction of rotation.
  Journal of the American College of Cardiology 1997 Olgin JE, Kalman JM, Saxon LA, Lee RJ, Lesh MD
• Biophysical characteristics of radiofrequency lesion formation in vivo: dynamics of catheter tip-tissue contact evaluated by intracardiac echocardiography.
  American heart journal 1997 Kalman JM, Fitzpatrick AP, Olgin JE, Chin MC, Lee RJ, Scheinman MM, Lesh MD
• Postextrasystolic U wave augmentation, a new marker of increased arrhythmic risk in patients without the long QT syndrome.
  Journal of the American College of Cardiology 1996 Viskin S, Heller K, Barron HV, Kitzis I, Hamdan M, Olgin JE, Wong MJ, Grant SE, Lesh MD
• Selective catheter ablation of the tachycardia focus in patients with nonreentrant junctional tachycardia.
  The American journal of cardiology 1996 Hamdan M, Van Hare GF, Fisher W, Gonzalez R, Dorostkar P, Lee R, Lesh M, Saxon L, Kalman J, Scheinman M
• Cost efficacy modeling of catheter reuse for percutaneous transluminal coronary angioplasty.
  Journal of the American College of Cardiology 1996 Lesh MD
• Deconvolution: a novel signal processing approach for determining activation time from fractionated electrograms and detecting infarcted tissue.
  Circulation 1996 Ellis WS, Eisenberg SJ, Auslander DM, Dae MW, Zakhor A, Lesh MD
• Conduction barriers in human atrial flutter: correlation of electrophysiology and anatomy.
  Journal of cardiovascular electrophysiology 1996 Olgin JE, Kalman JM, Lesh MD
• Effect of patient characteristics on the yield of prolonged baseline head-up tilt testing and the additional yield of drug provocation.
  Heart (British Cardiac Society) 1996 Fitzpatrick AP, Lee RJ, Epstein LM, Lesh MD, Eisenberg S, Sheinman MM
• Long-term results of electrophysiologically guided sotalol therapy for life-threatening ventricular arrhythmias.
  American heart journal 1996 Lee RJ, Wong M, Siu A, Namekawa-Wong M, Epstein LM, Fitzpatrick AP, Grogin HR, Scheinman MM, Lesh MD
• Mode of onset of torsade de pointes in congenital long QT syndrome.
  Journal of the American College of Cardiology 1996 Viskin S, Alla SR, Barron HV, Heller K, Saxon L, Kitzis I, Hare GF, Wong MJ, Lesh MD, Scheinman MM
• Modeling triggered cardiac activity: an analysis of the interactions between potassium blockade, rhythm pauses, and cellular coupling.
  Mathematical biosciences 1996 Gibb WJ, Wagner MB, Lesh MD
• Radiofrequency catheter ablation of ventricular tachycardia in right ventricular cardiomyopathy: use of concealed entrainment to identify the slow conduction isthmus bounded by an aneurysm and the tricuspid annulus.
  Journal of cardiovascular electrophysiology 1996 Stark SI, Arthur A, Lesh MD
• Transcatheter subendocardial infusion. A novel technique for mapping and ablation of ventricular myocardium.
  Circulation 1996 Goette A, Hartung W, Lesh M, Honeycutt C, Fleischman S, Swanson D, Langberg J
• Percutaneous multielectrode endocardial mapping during ventricular tachycardia in the swine model.
  Circulation 1996 Eldar M, Fitzpatrick AP, Ohad D, Smith MF, Hsu S, Whayne JG, Vered Z, Rotstein Z, Kordis T, Swanson DK, Chin M, Scheinman MM, Lesh MD, Greenspon AJ
• Regional entrainment of atrial fibrillation in man.
  Journal of cardiovascular electrophysiology 1996 kalman JM, Olgin JE, Karch MR, Lesh MD
• Activation and entrainment mapping defines the tricuspid annulus as the anterior barrier in typical atrial flutter.
  Circulation 1996 Kalman JM, Olgin JE, Saxon LA, Fisher WG, Lee RJ, Lesh MD
• Pathological findings following slow pathway ablation for AV nodal reentrant tachycardia.
  Journal of cardiovascular electrophysiology 1996 Olgin JE, Ursell P, Kao AK, Lesh MD
• Mapping and radiofrequency ablation of intraatrial reentrant tachycardia after the Senning or Mustard procedure for transposition ofthe great arteries.
  The American journal of cardiology 1996 Van Hare GF, Lesh MD, Ross BA, Perry JC, Dorostkar PC
• Results of radiofrequency catheter ablation for atrial flutter.
  The American journal of cardiology 1996 Saxon LA, Kalman JM, Olgin JE, Scheinman MM, Lee RJ, Lesh MD
• To fumble flutter or tackle "tach"? Toward updated classifiers for atrial tachyarrhythmias.
  Journal of cardiovascular electrophysiology 1996 Lesh MD, Kalman JM
• Autonomic nervous system and sudden cardiac death.
  Journal of the American College of Cardiology 1996 Barron HV, Lesh MD
• New approaches to treatment of atrial flutter and tachycardia.
  Journal of cardiovascular electrophysiology 1996 Lesh MD, Kalman JM, Olgin JE
• Quality of life and outcomes after radiofrequency His-bundle catheter ablation and permanent pacemaker implantation: impact of treatment in paroxysmal and established atrial fibrillation.
  American heart journal 1996 Fitzpatrick AP, Kourouyan HD, Siu A, Lee RJ, Lesh MD, Epstein LM, Griffin JC, Scheinman MM
• Ablation of 'incisional' reentrant atrial tachycardia complicating surgery for congenital heart disease. Use of entrainment to define a critical isthmus of conduction.
  Circulation 1996 Kalman JM, VanHare GF, Olgin JE, Saxon LA, Stark SI, Lesh MD
• In vitro quantification of radiofrequency ablation lesion size using intracardiac echocardiography in dogs.
  The American journal of cardiology 1996 Kalman JM, Jue J, Sudhir K, Fitzgerald P, Yock P, Lesh MD
• The role of atrial anatomy in clinical atrial arrhythmias.
  Journal of electrocardiology 1996 Lesh MD, Kalman JM, Olgin JE, Ellis WS
• Radiofrequency catheter modification of sinus pacemaker function guided by intracardiac echocardiography.
  Circulation 1995 Kalman JM, Lee RJ, Fisher WG, Chin MC, Ursell P, Stillson CA, Lesh MD, Scheinman MM
• Radiofrequency catheter modification of the sinus node for "inappropriate" sinus tachycardia.
  Circulation 1995 Lee RJ, Kalman JM, Fitzpatrick AP, Epstein LM, Fisher WG, Olgin JE, Lesh MD, Scheinman MM
• Use of P wave configuration during atrial tachycardia to predict site of origin.
  Journal of the American College of Cardiology 1995 Tang CW, Scheinman MM, Van Hare GF, Epstein LM, Fitzpatrick AP, Lee RJ, Lesh MD
• A model study of propagation of early afterdepolarizations.
  IEEE transactions on bio-medical engineering 1995 Wagner MB, Gibb WJ, Lesh MD
• Role of right atrial endocardial structures as barriers to conduction during human type I atrial flutter. Activation and entrainment mapping guided by intracardiac echocardiography.
  Circulation 1995 Olgin JE, Kalman JM, Fitzpatrick AP, Lesh MD
• Fractionated electrograms from a computer model of heterogeneously uncoupled anisotropic ventricular myocardium.
  Circulation 1995 Ellis WS, Auslander DM, Lesh MD
• Sudden cardiac death and polymorphous ventricular tachycardia in patients with normal QT intervals and normal systolic cardiac function.
  The American journal of cardiology 1995 Eisenberg SJ, Scheinman MM, Dullet NK, Finkbeiner WE, Griffin JC, Eldar M, Franz MR, Gonzalez R, Kadish AH, Lesh MD
• Radiofrequency catheter ablation of an atriofascicular connection guided by direct recording of a Mahaim potential.
  American heart journal 1995 Kusumoto FM, Lesh MD
• A direct midseptal approach to slow atrioventricular nodal pathway ablation.
  Pacing and clinical electrophysiology : PACE 1995 Epstein LM, Lesh MD, Griffin JC, Lee RJ, Scheinman MM
• Intracardiac echocardiography during radiofrequency catheter ablation of cardiac arrhythmias in humans.
  Journal of the American College of Cardiology 1994 Chu E, Kalman JM, Kwasman MA, Jue JC, Fitzgerald PJ, Epstein LM, Schiller NB, Yock PG, Lesh MD
• Clinical and electrophysiologic features and role of catheter ablation techniques in adult patients with automatic atrioventricular junctional tachycardia.
  The American journal of cardiology 1994 Scheinman MM, Gonzalez RP, Cooper MW, Lesh MD, Lee RJ, Epstein LM
• Clinical and electrophysiologic spectrum of fascicular tachycardias.
  American heart journal 1994 Gonzalez RP, Scheinman MM, Lesh MD, Helmy I, Torres V, Van Hare GF
• Radiofrequency catheter ablation of atriofascicular and nodoventricular Mahaim tracts.
  Circulation 1994 Grogin HR, Lee RJ, Kwasman M, Epstein LM, Schamp DJ, Lesh MD, Scheinman MM
• Effects of simulated potassium blockade on the dynamics of triggered cardiac activity.
  Journal of theoretical biology 1994 Gibb WJ, Wagner MB, Lesh MD
• Electrophysiological laboratory, electrophysiologist-implanted, nonthoracotomy-implantable cardioverter/defibrillators.
  Circulation 1994 Fitzpatrick AP, Lesh MD, Epstein LM, Lee RJ, Siu A, Merrick S, Griffin JC, Scheinman MM
• Follow-up of radiofrequency catheter ablation in children: results in 100 consecutive patients.
  Journal of the American College of Cardiology 1994 Van Hare GF, Witherell CL, Lesh MD
• Radiofrequency catheter ablation as a cure for idiopathic tachycardia of both left and right ventricular origin.
  Journal of the American College of Cardiology 1994 Coggins DL, Lee RJ, Sweeney J, Chein WW, Van Hare G, Epstein L, Gonzalez R, Griffin JC, Lesh MD, Scheinman MM
• Radiofrequency catheter ablation in the treatment of supraventricular tachycardia in the elderly.
  Journal of the American College of Cardiology 1994 Epstein LM, Chiesa N, Wong MN, Lee RJ, Griffin JC, Scheinman MM, Lesh MD
• Status of ablation in patients with atrial tachycardia and flutter.
  Pacing and clinical electrophysiology : PACE 1994 Lesh MD, Van Hare GF
• Radiofrequency catheter ablation guided by intracardiac echocardiography.
  Circulation 1994 Chu E, Fitzpatrick AP, Chin MC, Sudhir K, Yock PG, Lesh MD
• Radiofrequency catheter ablation of atrial arrhythmias. Results and mechanisms.
  Circulation 1994 Lesh MD, Van Hare GF, Epstein LM, Fitzpatrick AP, Scheinman MM, Lee RJ, Kwasman MA, Grogin HR, Griffin JC
• Effects of coupling heterogeneity on fractionated electrograms in a model of nonuniformly anisotropic ventricular myocardium.
  Journal of electrocardiology 1994 Ellis WS, Auslander DM, Lesh MD
• Interventional electrophysiology. State-of-the-art and future directions.
  Journal of electrocardiology 1994 Lesh MD
• New algorithm for the localization of accessory atrioventricular connections using a baseline electrocardiogram.
  Journal of the American College of Cardiology 1994 Fitzpatrick AP, Gonzales RP, Lesh MD, Modin GW, Lee RJ, Scheinman MM
• Radionuclide imaging tools for understanding arrhythmia mechanisms.
  Journal of electrocardiology 1994 Dae MW, Lesh MD
• Coexisting Wolff-Parkinson-White syndrome and cardiac valve disease: a staged treatment approach with catheter ablation before operation.
  The Journal of thoracic and cardiovascular surgery 1993 Lesh MD, Rankin JS
• Ventricular septal summit stimulation in atrioventricular nodal reentrant tachycardia.
  The American journal of cardiology 1993 Chien WW, Wang YS, Epstein LM, Cohen TJ, Lesh MD, Griffin JC, Scheinman MM
• Financial audit of antitachycardia pacing for the control of recurrent supraventricular tachycardia.
  British heart journal 1993 Fitzpatrick AP, Epstein LM, Lesh MD
• Interventional electrophysiology--state-of-the-art 1993.
  American heart journal 1993 Lesh MD
• Radiofrequency catheter ablation of an accessory pathway with discontinuous retrograde conduction: potential insight into mechanism of longitudinal dissociation.
  American heart journal 1993 Chien WW, Lesh MD
• Radiofrequency catheter ablation of supraventricular arrhythmias in patients with congenital heart disease: results and technical considerations.
  Journal of the American College of Cardiology 1993 Van Hare GF, Lesh MD, Stanger P
• Comparison of the retrograde and transseptal methods for ablation of left free wall accessory pathways.
  Journal of the American College of Cardiology 1993 Lesh MD, Van Hare GF, Scheinman MM, Ports TA, Epstein LA
• Pacemaker communications.
  Pacing and clinical electrophysiology : PACE 1993 Goldschlager N, Lesh M
• Effect of preexcitation on Doppler indexes of left ventricular filling.
  The American journal of cardiology 1993 Jue J, Winslow T, Ossipov M, Lesh MD, Schiller NB
• A new statistical appraisal of baseline ECG features for localization of accessory pathways.
  Journal of electrocardiology 1993 Fitzpatrick AP, Lesh MD
• Curing reentrant atrial arrhythmias. Targeting protected zones of slow conduction by catheter ablation.
  Journal of electrocardiology 1993 Lesh MD, Van Hare GF, Fitzpatrick AP, Griffin JC, Chu E
• Electrocardiographic and electrophysiologic characteristics of anterior, midseptal and right anterior free wall accessory pathways.
  Journal of the American College of Cardiology 1992 Scheinman MM, Wang YS, Van Hare GF, Lesh MD
• Coronary air embolism complicating transseptal radiofrequency ablation of left free-wall accessory pathways.
  Pacing and clinical electrophysiology : PACE 1992 Lesh MD, Coggins DL, Ports TA
• Importance of recording the right bundle branch deflection in the diagnosis of His-Purkinje reentrant tachycardia.
  Pacing and clinical electrophysiology : PACE 1992 Chien WW, Scheinman MM, Cohen TJ, Lesh MD
• Curative percutaneous catheter ablation using radiofrequency energy for accessory pathways in all locations: results in 100 consecutive patients.
  Journal of the American College of Cardiology 1992 Lesh MD, Van Hare GF, Schamp DJ, Chien W, Lee MA, Griffin JC, Langberg JJ, Cohen TJ, Lurie KG, Scheinman MM
• Electrophysiological findings and long-term follow-up of patients with the permanent form of junctional reciprocating tachycardia treated by catheter ablation.
  Circulation 1992 Chien WW, Cohen TJ, Lee MA, Lesh MD, Griffin JC, Schiller NB, Scheinman MM
• Patients with supraventricular tachycardia presenting with aborted sudden death: incidence, mechanism and long-term follow-up.
  Journal of the American College of Cardiology 1991 Wang YS, Scheinman MM, Chien WW, Cohen TJ, Lesh MD, Griffin JC
• Radiofrequency catheter ablation for treatment of bundle branch reentrant ventricular tachycardia: results and long-term follow-up.
  Journal of the American College of Cardiology 1991 Cohen TJ, Chien WW, Lurie KG, Young C, Goldberg HR, Wang YS, Langberg JJ, Lesh MD, Lee MA, Griffin JC
• Radiofrequency catheter ablation for Wolff-Parkinson-White syndrome associated with a coronary sinus diverticulum.
  Pacing and clinical electrophysiology : PACE 1991 Lesh MD, Van Hare G, Kao AK, Scheinman MM
• Implantable cardioverter defibrillator proarrhythmia: case report and review of the literature.
  Pacing and clinical electrophysiology : PACE 1991 Cohen TJ, Chien WW, Lurie KG, Lee MA, Lesh MD, Scheinman MM, Griffin JC
• Percutaneous radiofrequency catheter ablation for supraventricular arrhythmias in children.
  Journal of the American College of Cardiology 1991 Van Hare GF, Lesh MD, Scheinman M, Langberg JJ
• Pacemaker generator pseudomalfunction: an artifact of Holter monitoring.
  Pacing and clinical electrophysiology : PACE 1991 Lesh MD, Langberg JJ, Griffin JC, Scheinman MM, Witherell CL
• Catheter modification of the atrioventricular junction with radiofrequency energy for control of atrioventricular nodal reentry tachycardia.
  Circulation 1991 Lee MA, Morady F, Kadish A, Schamp DJ, Chin MC, Scheinman MM, Griffin JC, Lesh MD, Pederson D, Goldberger J
• Ablation of the atrioventricular junction with radiofrequency energy using a new electrode catheter.
  The American journal of cardiology 1991 Langberg JJ, Chin M, Schamp DJ, Lee MA, Goldberger J, Pederson DN, Oeff M, Lesh MD, Griffin JC, Scheinman MM
• A quantitative evaluation of refractoriness within a reentrant circuit during ventricular tachycardia. Relation to termination.
  Circulation 1990 Gottlieb CD, Rosenthal ME, Stamato NJ, Frame LH, Lesh MD, Miller JM, Josephson ME
• Effect of cellular uncoupling by heptanol on conduction in infarcted myocardium.
  Circulation research 1990 Spear JF, Balke CW, Lesh MD, Kadish AH, Levine JL, Moore EN
• Cellular uncoupling can unmask dispersion of action potential duration in ventricular myocardium. A computer modeling study.
  Circulation research 1989 Lesh MD, Pring M, Spear JF
• Alterations in diastolic function in response to progressive left ventricular hypertrophy.
  Journal of the American College of Cardiology 1989 Douglas PS, Berko B, Lesh M, Reichek N
• Effects of cellular uncoupling on conduction in anisotropic canine ventricular myocardium.
  Circulation research 1988 Balke CW, Lesh MD, Spear JF, Kadish A, Levine JH, Moore EN
• A computer model of the electrogram: what causes fractionation?
  Journal of electrocardiology 1988 Lesh MD, Spear JF, Simson MB
• A three dimensional multi-segmental analysis of the energetics of normal and pathological human gait.
  Journal of biomechanics 1982 Mansour JM, Lesh MD, Nowak MD, Simon SR