Michael Lee
Executive Director
Vice Chanc Research
Chancellor/EVC/FAS

Websites

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• Research Resource Program (rrp.ucsf.edu)
• Monoclonal Antibody Core (antibodies.ucsf.edu)
• Parnassus Flow Cytometry Core (flow.ucsf.edu)

Grants and Projects

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• BD FACSAria Fusion Cell Sorter, NIH, 2016-2017

Publications (9)

Top publication keywords:
T-Lymphocytes, RegulatoryTh1 CellsGene EditingMice, Inbred NODIslets of Langerhans TransplantationTissue and Organ HarvestingCollagenasesReceptors, Antigen, T-CellDiabetes Mellitus, Type 1T-Box Domain ProteinsForkhead Transcription FactorsGenome, HumanIslets of LangerhansCellular ReprogrammingReceptors, Interleukin-7

• Reprogramming human T cell function and specificity with non-viral genome targeting.
  Nature 2018 Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta…
• Type 1 diabetes immunotherapy using polyclonal regulatory T cells.
  Science translational medicine 2015 Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q
• Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.
  Journal of immunology (Baltimore, Md. : 1950) 2011 McClymont SA, Putnam AL, Lee MR, Esensten JH, Liu W, Hulme MA, Hoffmüller U, Baron U, Olek S, Bluestone JA, Brusko TM
• Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.
  PloS one 2010 Brusko TM, Koya RC, Zhu S, Lee MR, Putnam AL, McClymont SA, Nishimura MI, Han S, Chang LJ, Atkinson MA, Ribas A, Bluestone JA
• Successful clinical islet isolation using a GMP-manufactured collagenase and neutral protease.
  Transplantation 2009 Szot GL, Lee MR, Tavakol MM, Lang J, Dekovic F, Kerlan RK, Stock PG, Posselt AM

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• T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Esensten JH, Lee MR, Glimcher LH, Bluestone JA
• Expansion of human regulatory T-cells from patients with type 1 diabetes.
  Diabetes 2008 Putnam AL, Brusko TM, Lee MR, Liu W, Szot GL, Ghosh T, Atkinson MA, Bluestone JA
• Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, Bluestone JA
• CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells.
  The Journal of experimental medicine 2006 Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B, Clayberger C, Soper DM, Ziegler SF, Bluestone JA