Michael Kattah, MD, PhD
Assistant Professor
Medicine
School of Medicine

As an Assistant Professor in the Division of GI at UCSF, I am interested in the molecular underpinnings of intestinal inflammation and Inflammatory Bowel Disease (IBD). We employ a variety of tools to study intestinal epithelial cells and death signaling pathways in mouse models, patient-derived biopsies, and organoids.

Awards

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• Young Physician Scientist Award, American Society for Clinical Investigation, 2021
• Recognition for Scientific Accomplishment as an Early Stage Investigator, DDW 2016, 2016
• Resident Mentoring Award, Brigham and Women's Hospital, 2012
• Hugh McDevitt Award, Stanford University, 2008

Education & Training

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• Gastroenterology Fellowship Gastroenterology/Medicine UCSF 2016
• Medicine Residency Medicine Brigham and Women's Hospital 2012
• MD/PhD Medicine Stanford University 2010

Interests

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• CD
• Genomics
• Intestinal Organoids
• Proteomics
• Innate Immunity
• Necroptosis
• Ubiquitin
• Crohn's Disease
• Apoptosis
• High-throughput Screening
• IBD
• UC
• Ulcerative Colitis
• Immunology
• Autoimmunity
• Precision Medicine
• Inflammatory Bowel Disease
• Drug Development

Websites

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• Kattah Lab (kattahlab.ucsf.edu)

Grants and Projects

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• A20 and ABIN-1 cooperatively preserve intestinal integrity, Burroughs Wellcome Fund Career Awards for Medical Scientists, 2020-2025
• Mechanisms of intestinal epithelial injury in intestinal inflammation, NIH, 2020-2024
• Tabula Sapiens, Chan-Zuckerberg Biohub, 2022-2023
• AutoImmunoprofiler (AutoIPI), Eli Lilly, 2021-2023
• Clinical cohort and corresponding cell atlas for patients with intestinal inflammation, Department of Medicine UCSF, 2019-2021

Publications (50)

Top publication keywords:
Cyclooxygenase InhibitorsTumor Necrosis Factor alpha-Induced Protein 3ColitisAutoantibodiesProtein Array AnalysisInflammatory Bowel DiseasesColitis, UlcerativeUbiquitin-Protein Ligase ComplexesIpilimumabB-Lymphocyte SubsetsNod1 Signaling Adaptor ProteinImmunophenotypingT-Lymphocyte SubsetsLymphotoxin-alphaDeubiquitinating Enzymes

• Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage.
  The Journal of clinical investigation 2022 Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG
• Balancing the Checkpoint: Managing Colitis Associated with Dual Checkpoint Inhibitors and High-Dose Aspirin.
  Digestive diseases and sciences 2019 Hammami MB, Gill R, Thiruvengadam N, Oh DY, Beck K, Mahadevan U, Kattah MG
• A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival.
  The Journal of experimental medicine 2018 Kattah MG, Shao L, Rosli YY, Shimizu H, Whang MI, Advincula R, Achacoso P, Shah S, Duong BH, Onizawa M, Tanbun P, Malynn BA, Ma A
• Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants.
  Clinical and translational gastroenterology 2018 Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U
• Cytokines secreted in response to Toll-like receptor ligand stimulation modulate differentiation of human Th17 cells.
  Arthritis and rheumatism 2008 Kattah MG, Wong MT, Yocum MD, Utz PJ

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• Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis.
  Nature communications 2024 Mennillo E, Kim YJ, Lee G, Rusu I, Patel RK, Dorman LC, Flynn E, Li S, Bain JL, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Lotstein ML, Rahim M, Naser M, Bernard-Vazquez F, Eckalbar W, Cho SJ, Beck …
• VEDOLIZUMAB RESPONSE AND NON-RESPONSE IN ULCERATIVE COLITIS: INSIGHTS FROM SPATIAL TRANSCRIPTOMICS.
  Gastroenterology 2024 Elvira Mennillo, Gyehyun Lee, Madison Lotstein, Jessica Tsui, Uma Mahadevan, Gabriela Fragiadakis, Alexis Combes, Michael Kattah
• VEDOLIZUMAB RESPONSE AND NON-RESPONSE IN ULCERATIVE COLITIS: INSIGHTS FROM SPATIAL TRANSCRIPTOMICS.
  Inflammatory Bowel Diseases 2024 Elvira Mennillo, Gyehyun Lee, Madison Lotstein, Jessica Tsui, Uma Mahadevan, Gabriela Fragiadakis, Alexis Combes, Michael Kattah
• Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis.
  bioRxiv : the preprint server for biology 2024 Mennillo E, Kim YJ, Lee G, Rusu I, Patel RK, Dorman LC, Flynn E, Li S, Bain JL, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Lotstein ML, Rahim M, Naser M, Bernard-Vazquez F, Eckalbar W, Cho SJ, Beck …
• 630 SINGLE-CELL AND SPATIAL MULTI-OMICS IDENTIFY INNATE AND STROMAL MODULES TARGETED BY ANTI-INTEGRIN THERAPY IN ULCERATIVE COLITIS.
  Gastroenterology 2023 Elvira Mennillo, Yang Joon Kim, Iulia Rusu, Gyehyun Lee, Leah Dorman, Faviola Bernard-Vazquez, Jared Bain, Ravi K. Patel, Christopher Andersen, Stanley Tamaki, Jessica Tsui, Kendall Beck, Najwa El-…
• A20 Restricts NOS2 Expression and Intestinal Tumorigenesis in a Mouse Model of Colitis-Associated Cancer.
  Gastro hep advances 2022 Basta DW, Vong M, Beshimova A, Nakamura BN, Rusu I, Kattah MG, Shao L
• Vedolizumab Antagonizes MAdCAM-1-Dependent Human Placental Cytotrophoblast Adhesion and Invasion In Vitro.
  Inflammatory bowel diseases 2022 Blaisdell A, Zhou Y, Kattah MG, Fisher SJ, Mahadevan U
• Intestinal inflammation alters the antigen-specific immune response to a skin commensal.
  Cell reports 2022 Merana GR, Dwyer LR, Dhariwala MO, Weckel A, Gonzalez JR, Okoro JN, Cohen JN, Tamaki CM, Han J, Tasoff P, Palacios-Calderon Y, Ha CWY, Lynch SV, Segre JA, Kong HH, Kattah MG, Ma A, Scharschmidt TC
• Tu1517: MICROBIAL SIGNALS, MYD88, AND LYMPHOTOXIN DRIVE TNFINDEPENDENT DEATH OF A20 AND ABIN-1 DEFICIENT EPITHELIUM.
  Gastroenterology 2022 Iulia Rusu, Elvira Mennillo, Jared L. Bain, Zhongmei Li, Xiaofei Sun, Kimberly Ly, Yenny Y. Rosli, Mohammad Naser, Zunqiu Wang, Rommel Advincula, Philip Achacoso, Ling Shao, Bahram Razani, Ophir D. …
• Importance of Not MSing Cerebral White Matter Disease in Patients with Inflammatory Bowel Disease.
  Digestive diseases and sciences 2020 Regner EH, Green AJ, Bain JL, Kattah MG, Mahadevan U
• A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis.
  PloS one 2019 Talpin A, Kattah MG, Advincula R, Fadrosh D, Lynch K, LaMere B, Fujimura KE, Nagalingam NA, Malynn BA, Lynch SV, Ma A
• Correction: Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants.
  Clinical and translational gastroenterology 2018 Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U
• Effect of I-scan Electronic Chromoendoscopy on Detection of Adenomas During Colonoscopy.
  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2018 Kidambi TD, Terdiman JP, El-Nachef N, Singh A, Kattah MG, Lee JK
• A20 regulates canonical wnt-signaling through an interaction with RIPK4.
  PloS one 2018 Nakamura BN, Glazier A, Kattah MG, Duong B, Jia Y, Campo D, Shao L
• A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function.
  PLoS pathogens 2018 Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM
• Ubiquitin-Modifying Enzymes and Regulation of the Inflammasome.
  Journal of molecular biology 2017 Kattah MG, Malynn BA, Ma A
• 332e Multiparameter Flow Cytometry Reveals Differences in B Cells Subsets among Infants Born to Mothers being Treated for IBD.
  Gastroenterology 2017 Michael Kattah, Jeffrey Milush, Trevor Burt, Uma Mahadevan
• The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells.
  Immunity 2017 Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A
• P-285 A20 and ABIN-1 Cooperate to Preserve Intestinal Epithelial Homeostasis.
  Inflammatory Bowel Diseases 2017 Michael Kattah, Ling Shao, Yenny Rosli, Michael Whang, Rommel Advincula, Barbara Malynn, Averil Ma
• Effect of Intense Exercise on Inflammatory Bowel Disease Activity.
  The American Journal of Gastroenterology 2016 Benjamin Hassid, Brandon Lamere, Michael Kattah, Uma Mahadevan
• 245 A20 and ABIN-1 Cooperate to Restrict Intestinal Epithelial Cell Death and Maintain Mucosal Immune Homeostasis.
  Gastroenterology 2016 Ling Shao, Michael G. Kattah, Michael Whang, Bao Duong, Michio Onizawa, Sadeea Abbasi, Yenny Rosli, Joseph Callahan, Mihir Pendse, Julio Barrera, Alison Glazier, Rommel Advincula, Barbara Malynn, …
• Confocal laser endomicroscopy for membrane-bound tumor necrosis factor predicts response to therapy in Crohn's disease.
  Gastroenterology 2015 Kattah MG, Mahadevan U
• Tetramers reveal IL-17-secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Kattah NH, Newell EW, Jarrell JA, Chu AD, Xie J, Kattah MG, Goldberger O, Ye J, Chakravarty EF, Davis MM, Utz PJ
• Measurement of mast cell surface molecules by high-throughput immunophenotyping using transcription (HIT).
  Methods in molecular biology (Clifton, N.J.) 2015 Haddon DJ, Jarrell JA, Hughes MR, Snyder K, McNagny KM, Kattah MG, Utz PJ
• Insights into the molecular pathophysiology of inflammatory bowel disease: ATG16L1 suppresses nod-driven inflammation.
  Gastroenterology 2014 Kattah MG, Mahadevan U
• Antigen Specific T Cells in Lupus Recognize U1-70 and Produce IL-17 by Tetramer Staining.
  Clinical Immunology 2010 Nicole Kattah, Evan Newell, Alvina Chu, Michael Kattah, Mark Davis
• The U1-snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases.
  Immunological reviews 2010 Kattah NH, Kattah MG, Utz PJ
• Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Lin JT, Lineberry NB, Kattah MG, Su LL, Utz PJ, Fathman CG, Wu L
• OR.85. Regulation of GRAIL Expression by mTOR Controls Naive CD4 T Cell Proliferation.
  Clinical Immunology 2009 Jack Lin, Neil Lineberry, Michael Kattah, Leon Su, Paul Utz, C. Garrison Fathman
• Differential regulation of chemokines by IL-17 in colonic epithelial cells.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Lee JW, Wang P, Kattah MG, Youssef S, Steinman L, DeFea K, Straus DS
• Protein microarrays with carbon nanotubes as multicolor Raman labels.
  Nature biotechnology 2008 Chen Z, Tabakman SM, Goodwin AP, Kattah MG, Daranciang D, Wang X, Zhang G, Li X, Liu Z, Utz PJ, Jiang K, Fan S, Dai H
• HIT: a versatile proteomics platform for multianalyte phenotyping of cytokines, intracellular proteins and surface molecules.
  Nature medicine 2008 Kattah MG, Coller J, Cheung RK, Oshidary N, Utz PJ
• Protein microarrays address the elephant in the room.
  Clinical chemistry 2008 Kattah MG, Utz PJ, Balboni I
• OR.40. Cytokines Secreted in Response to TLR-ligand Stimulation Modulate Human Th17 Differentiation.
  Clinical Immunology 2008 Michael Kattah, Michael Wong, Matthew Yocum, Paul Utz
• Sa.12. Profiling Epigenetic Biomarkers for the Study and Treatment of Lupus.
  Clinical Immunology 2008 Chih Long Liu, Michael Kattah, Alex Kuo, Xiaobing Shi, Imelda Balboni, Paul Utz, Or Gozani
• Sa.95. HIT: A Novel Protein Array Platform Identifies Down-regulation of CD26 on Regulatory T Cell Subsets.
  Clinical Immunology 2008 Michael Kattah, John Coller, Regina Cheung, Neekaan Oshidary, Paul Utz
• Free-solution oligonucleotide separation in nanoscale channels.
  Analytical chemistry 2007 Pennathur S, Baldessari F, Santiago JG, Kattah MG, Steinman JB, Utz PJ
• Antibody-oligo Arrays for Multiplex Surface Marker Profiling of Immune Cells Subsets.
  Clinical Immunology 2007 Michael Kattah, John Coller, Golnaz Alemi, Neekaan Oshidary, Paul J. Utz
• A new two-color Fab labeling method for autoantigen protein microarrays.
  Nature methods 2006 Kattah MG, Alemi GR, Thibault DL, Balboni I, Utz PJ
• Medicine on a need-to-know basis.
  Nature immunology 2006 Busch R, Byrne B, Gandrud L, Sears D, Meyer E, Kattah M, Kurihara C, Haertel E, Parnes JR, Mellins ED
• Multiplexed protein array platforms for analysis of autoimmune diseases.
  Annual review of immunology 2006 Balboni I, Chan SM, Kattah M, Tenenbaum JD, Butte AJ, Utz PJ
• Sa.127. A Novel Two-Color Fab Labeling Method for Autoantigen Protein Microarrays.
  Clinical Immunology 2006 Michael Kattah, Golnaz Alemi, Donna Thibault, Paul Utz
• Structure-based discovery of nonpeptidic small organic compounds to block the T cell response to myelin basic protein.
  Journal of medicinal chemistry 2004 Koehler NK, Yang CY, Varady J, Lu Y, Wu XW, Liu M, Yin D, Bartels M, Xu BY, Roller PP, Long YQ, Li P, Kattah M, Cohn ML, Moran K, Tilley E, Richert JR, Wang S
• Crystal structure of the human myeloid cell activating receptor TREM-1.
  Structure (London, England : 1993) 2003 Radaev S, Kattah M, Rostro B, Colonna M, Sun PD
• Generating isomorphous heavy-atom derivatives by a quick-soak method. Part I: test cases.
  Acta crystallographica. Section D, Biological crystallography 2002 Sun PD, Radaev S, Kattah M