Michael Gropper, MD, PhD
Professor
Anesthesia
School of Medicine

Professor and Chair Department of Anesthesia and Perioperative Care

Awards

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• 3rd Henning Pontoppidan Lecture, Harvard Medical School, 2013

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California 2018
• Fellowship Critical Care Medicine UCSF 1994
• Residency Anesthesiology University of California, San Francisco 1993
• M.D. School of Medicine University of California Los Angeles 1989
• Ph.D. Graduate Division (Physiology) University of California, San Francisco 1985

Websites

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• Clinical Profile at UCSF Medical Center (ucsfhealth.org)

Publications (104)

Top publication keywords:
Critical IllnessPatient CareEarly AmbulationAnesthesia, InhalationCritical CareAcute Lung InjuryErythrocyte TransfusionIntensive Care UnitsPseudomonas aeruginosaNear Miss, HealthcareMuscle WeaknessInterprofessional RelationsRespiratory InsufficiencyTransfusion ReactionPseudomonas Infections

• A Least Absolute Shrinkage and Selection Operator-Derived Predictive Model for Postoperative Respiratory Failure in a Heterogeneous Adult Elective Surgery Patient Population.
  CHEST critical care 2023 Stocking JC, Taylor SL, Fan S, Wingert T, Drake C, Aldrich JM, Ong MK, Amin AN, Marmor RA, Godat L, Cannesson M, Gropper MA, Utter GH, Sandrock CE, Bime C, Mosier J, Subbian V, Adams JY, Kenyon NJ, …
• Outcomes and risk factors for delayed-onset postoperative respiratory failure: a multi-center case-control study by the University of California Critical Care Research Collaborative (UC3RC).
  BMC anesthesiology 2022 Stocking JC, Drake C, Aldrich JM, Ong MK, Amin A, Marmor RA, Godat L, Cannesson M, Gropper MA, Romano PS, Sandrock C, Bime C, Abraham I, Utter GH
• Quality of Life Improvement: A Novel Framework and Approach to Well-Being.
  Anesthesiology clinics 2022 Sinskey JL, Chang JM, Nicholau D, Gropper MA
• Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.
  The New England journal of medicine 2021 Hughes CG, Mailloux PT, Devlin JW, Swan JT, Sanders RD, Anzueto A, Jackson JC, Hoskins AS, Pun BT, Orun OM, Raman R, Stollings JL, Kiehl AL, Duprey MS, Bui LN, O'Neal HR, Snyder A, Gropper MA, …
• Risk Factors Associated With Early Postoperative Respiratory Failure: A Matched Case-Control Study.
  The Journal of surgical research 2021 Stocking JC, Drake C, Aldrich JM, Ong MK, Amin A, Marmor RA, Godat L, Cannesson M, Gropper MA, Romano PS, Utter GH

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• Consensus-based perioperative protocols during the COVID-19 pandemic.
  Journal of neurosurgery. Spine 2020 Mummaneni PV, Burke JF, Chan AK, Sosa JA, Lobo EP, Mummaneni VP, Antrum S, Berven SH, Conte MS, Doernberg SB, Goldberg AN, Hess CP, Hetts SW, Josephson SA, Kohi MP, Ma CB, Mahadevan VS, Molinaro AM, …
• Postoperative respiratory failure: An update on the validity of the Agency for Healthcare Research and Quality Patient Safety Indicator 11 in an era of clinical documentation improvement programs.
  American journal of surgery 2019 Stocking JC, Utter GH, Drake C, Aldrich JM, Ong MK, Amin A, Marmor RA, Godat L, Cannesson M, Gropper MA, Romano PS
• Heterogeneity in Intensive Care: Low Severity Does Not Mean Low Risk!
  Anesthesiology 2019 Pirracchio R, Gropper MA
• Developing a Comprehensive Model of Intensive Care Unit Processes: Concept of Operations.
  Journal of patient safety 2018 Romig M, Tropello SP, Dwyer C, Wyskiel RM, Ravitz A, Benson J, Gropper MA, Pronovost PJ, Sapirstein A
• Intensive care unit providers more quickly and accurately assess risk of multiple harms using an engineered safety display.
  Health informatics journal 2018 Romig M, Carolan H, Ravitz A, Schell-Chaple H, Yoon E, Dwyer C, Thornton K, Gropper M, Pronovost PJ, Sapirstein A
• Interprofessional Care and Teamwork in the ICU.
  Critical care medicine 2018 Donovan AL, Aldrich JM, Gross AK, Barchas DM, Thornton KC, Schell-Chaple HM, Gropper MA, Lipshutz AKM, University of California, San Francisco Critical Care Innovations Group
• Dr Ted Eger Obituary.
  Anesthesia and analgesia 2017 Gropper MA, Shafer SL
• Preventing Harm in the ICU-Building a Culture of Safety and Engaging Patients and Families.
  Critical care medicine 2017 Thornton KC, Schwarz JJ, Gross AK, Anderson WG, Liu KD, Romig MC, Schell-Chaple H, Pronovost PJ, Sapirstein A, Gropper MA, Lipshutz AKM, Project Emerge Collaborators
• Differentiating pulmonary transfusion reactions using recipient and transfusion factors.
  Transfusion 2017 Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL, TRALI Study Group
• Why Physician Leaders of Health Care Organizations Should Participate in Direct Patient Care.
  Annals of internal medicine 2017 Detsky AS, Gropper MA
• An Ethnographic Study of Health Information Technology Use in Three Intensive Care Units.
  Health services research 2017 Leslie M, Paradis E, Gropper MA, Kitto S, Reeves S, Pronovost P
• Why Physician Leaders of Health Care Organizations Should Participate in Direct Patient Care.
  Annals of internal medicine 2016 Detsky AS, Gropper MA
• A Typology of ICU Patients and Families from the Clinician Perspective: Toward Improving Communication.
  Health communication 2016 Leslie M, Paradis E, Gropper MA, Milic MM, Kitto S, Reeves S, Pronovost P
• The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor.
  Anesthesia and analgesia 2016 Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung JM
• Predicting mortality in the intensive care unit: a comparison of the University Health Consortium expected probability of mortality and the Mortality Prediction Model III.
  Journal of intensive care 2016 Lipshutz AK, Feiner JR, Grimes B, Gropper MA
• IV Immunoglobulin: A Useful Tool for the Severe Pneumonia Toolbox?
  Critical care medicine 2016 Crowley JC, Gropper MA
• Intensive Care Unit-acquired Muscle Weakness: An Ounce of Prevention Is Worth a Pound of Cure.
  Anesthesiology 2016 Lipshutz AK, Gropper MA
• Interprofessional rhetoric and operational realities: an ethnographic study of rounds in four intensive care units.
  Advances in health sciences education : theory and practice 2015 Paradis E, Leslie M, Gropper MA
• A Clinical Trial to Detect Subclinical Transfusion-induced Lung Injury during Surgery.
  Anesthesiology 2015 Feiner JR, Gropper MA, Toy P, Lieberman J, Twiford J, Weiskopf RB
• An analysis of near misses identified by anesthesia providers in the intensive care unit.
  BMC anesthesiology 2015 Lipshutz AK, Caldwell JE, Robinowitz DL, Gropper MA
• Preoperative medical testing in Medicare patients undergoing cataract surgery.
  The New England journal of medicine 2015 Chen CL, Lin GA, Bardach NS, Clay TH, Boscardin WJ, Gelb AW, Maze M, Gropper MA, Dudley RA
• Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions.
  Transfusion 2015 Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL, TRALI Study Group
• Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.
  Transfusion 2014 Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, …
• Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*.
  Critical care medicine 2014 Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, …
• Delivering interprofessional care in intensive care: a scoping review of ethnographic studies.
  American journal of critical care : an official publication, American Association of Critical-Care Nurses 2014 Paradis E, Leslie M, Puntillo K, Gropper M, Aboumatar HJ, Kitto S, Reeves S
• Say no to old blood*.
  Critical care medicine 2013 Gilliss BM, Gropper MA
• Applying ethnography to the study of context in healthcare quality and safety.
  BMJ quality & safety 2013 Leslie M, Paradis E, Gropper MA, Reeves S, Kitto S
• ICU early mobilization: from recommendation to implementation at three medical centers.
  Critical care medicine 2013 Engel HJ, Needham DM, Morris PE, Gropper MA
• Interprofessional care in intensive care settings and the factors that impact it: results from a scoping review of ethnographic studies.
  Journal of critical care 2013 Paradis E, Leslie M, Gropper MA, Aboumatar HJ, Kitto S, Reeves S
• Exploring the nature of interprofessional collaboration and family member involvement in an intensive care context.
  Journal of interprofessional care 2013 Paradis E, Reeves S, Leslie M, Aboumatar H, Chesluk B, Clark P, Courtenay M, Franck L, Lamb G, Lyndon A, Mesman J, Puntillo K, Schmitt M, van Soeren M, Wachter B, Zwarenstein M, Gropper M, Kitto S
• Postoperative respiratory muscle dysfunction: only the strong survive.
  Anesthesiology 2013 Gropper MA
• Risk factors and outcomes in transfusion-associated circulatory overload.
  The American journal of medicine 2013 Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P, TRALI Study Group
• Acquired neuromuscular weakness and early mobilization in the intensive care unit.
  Anesthesiology 2013 Lipshutz AK, Gropper MA
• Challenge of assessing symptoms in seriously ill intensive care unit patients: can proxy reporters help?
  Critical care medicine 2012 Puntillo KA, Neuhaus J, Arai S, Paul SM, Gropper MA, Cohen NH, Miaskowski C
• Central venous catheters: follow the evidence, not the guidelines.
  Critical care medicine 2012 Lipshutz AK, Gropper MA
• Organ donation after cardiac death in amyotrophic lateral sclerosis.
  Annals of neurology 2012 Toossi S, Lomen-Hoerth C, Josephson SA, Gropper MA, Roberts J, Patton K, Smith WS
• Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans.
  Anesthesia and analgesia 2012 Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA
• Transfusion-related acute lung injury: incidence and risk factors.
  Blood 2011 Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, …
• Reducing noninfectious risks of blood transfusion.
  Anesthesiology 2011 Gilliss BM, Looney MR, Gropper MA
• Prediction is very difficult, especially about the future-Niels Bohr.
  Critical care medicine 2011 Donovan AL, Gropper MA
• Critical care issues in patients after liver transplantation.
  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2011 Razonable RR, Findlay JY, O'Riordan A, Burroughs SG, Ghobrial RM, Agarwal B, Davenport A, Gropper M
• Symptoms experienced by intensive care unit patients at high risk of dying.
  Critical care medicine 2010 Puntillo KA, Arai S, Cohen NH, Gropper MA, Neuhaus J, Paul SM, Miaskowski C
• Special article: rescue therapies for acute hypoxemic respiratory failure.
  Anesthesia and analgesia 2010 Liu LL, Aldrich JM, Shimabukuro DW, Sullivan KR, Taylor JM, Thornton KC, Gropper MA
• Can we predict pulmonary complications after thoracic surgery?
  Anesthesia and analgesia 2010 Aldrich JM, Gropper MA
• Ventilator-associated pneumonia in a neurologic intensive care unit does not lead to increased mortality.
  Neurocritical care 2010 Josephson SA, Moheet AM, Gropper MA, Nichols AD, Smith WS
• Looking forward, looking back: assessing variations in hospital resource use and outcomes for elderly patients with heart failure.
  Circulation. Cardiovascular quality and outcomes 2009 Ong MK, Mangione CM, Romano PS, Zhou Q, Auerbach AD, Chun A, Davidson B, Ganiats TG, Greenfield S, Gropper MA, Malik S, Rosenthal JT, Escarce JJ
• Critical care checklists, the Keystone Project, and the Office for Human Research Protections: a case for streamlining the approval process in quality-improvement research.
  Critical care medicine 2009 Savel RH, Goldstein EB, Gropper MA
• Noisy mechanical ventilation: listen to the melody.
  Anesthesiology 2009 Shimabukuro DW, Gropper MA
• Perioperative glycemic control: an evidence-based review.
  Anesthesiology 2009 Lipshutz AK, Gropper MA
• Postoperative infectious complications of abdominal solid organ transplantation.
  Journal of intensive care medicine 2008 Hlava N, Niemann CU, Gropper MA, Melcher ML
• Laboratory testing guidelines in the intensive care unit: less red and more green.
  Critical care medicine 2008 Sullivan K, Gropper MA
• Strategies for success: A PDSA analysis of three QI initiatives in critical care.
  Joint Commission journal on quality and patient safety 2008 Lipshutz AK, Fee C, Schell H, Campbell L, Taylor J, Sharpe BA, Nguyen J, Gropper MA
• The curse of the drinking class.
  Critical care medicine 2008 Yost CS, Gropper MA
• Tracheostomy protocol compliance: herding cats?
  Critical care medicine 2008 Liu L, Gropper MA
• The epithelium in acute lung injury/acute respiratory distress syndrome.
  Current opinion in critical care 2008 Gropper MA, Wiener-Kronish J
• Multisystem organ failure: predicting the future.
  Anesthesiology 2007 Gropper MA
• Critical care challenges in orthopedic surgery patients.
  Critical care medicine 2006 Taylor JM, Gropper MA
• Pulmonary edema after transfusion: how to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury.
  Critical care medicine 2006 Gajic O, Gropper MA, Hubmayr RD
• Recombinant factor VIIa reduces transfusion requirements in liver transplant patients with high MELD scores.
  Transfusion medicine (Oxford, England) 2006 Niemann CU, Behrends M, Quan D, Eilers H, Gropper MA, Roberts JP, Hirose R
• Establishing a comprehensive, evidence-based protocol for the care of patients with sepsis.
  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2005 Fee C, Gropper MA
• Impact of a series of interventions in vancomycin prescribing on use and prevalence of vancomycin-resistant enterococci.
  Joint Commission journal on quality and patient safety 2005 Guglielmo BJ, Dudas V, Maewal I, Young R, Hilts A, Villmann M, Gibbs L, Gropper M, Jacobs R
• Evidence-based management of critically ill patients: analysis and implementation.
  Anesthesia and analgesia 2004 Gropper MA
• Transfusion-related acute lung injury: a review.
  Chest 2004 Looney MR, Gropper MA, Matthay MA
• Look before you leap: how do intensivists improve care for critically ill patients?
  The American journal of medicine 2004 Gropper MA, Matthay MA
• Sepsis and hypothermia: call in the granulocytes?
  Anesthesiology 2003 Gropper MA
• Injury and repair in lung and airways.
  Critical care medicine 2003 Shimabukuro DW, Sawa T, Gropper MA
• Predicting mortality in acute respiratory distress syndrome: circulatory system knows best.
  Critical care medicine 2003 Misset B, Gropper MA, Wiener-Kronish JP
• Postoperative analgesia and sedation in the adult intensive care unit: a guide to drug selection.
  Drugs 2003 Liu LL, Gropper MA
• The alveolar epithelium: suspect or innocent bystander?
  Anesthesiology 2003 Gropper MA, Wiener-Kronish J
• Respiratory and Hemodynamic Management After Cardiac Surgery.
  Current treatment options in cardiovascular medicine 2002 Liu LL, Gropper MA
• A momentary pause...
  British journal of anaesthesia 2001 Gropper MA
• Protective effects of low tidal volume ventilation in a rabbit model of Pseudomonas aeruginosa-induced acute lung injury.
  Critical care medicine 2001 Savel RH, Yao EC, Gropper MA
• Etiology of acute pulmonary edema during liver transplantation : a series of cases with analysis of the edema fluid.
  Chest 2001 Yost CS, Matthay MA, Gropper MA
• Additive inhibition of nicotinic acetylcholine receptors by corticosteroids and the neuromuscular blocking drug vecuronium.
  Anesthesiology 2000 Kindler CH, Verotta D, Gray AT, Gropper MA, Yost CS
• Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia.
  The Journal of clinical investigation 1999 Kurahashi K, Kajikawa O, Sawa T, Ohara M, Gropper MA, Frank DW, Martin TR, Wiener-Kronish JP
• Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury.
  Nature medicine 1999 Sawa T, Yahr TL, Ohara M, Kurahashi K, Gropper MA, Wiener-Kronish JP, Frank DW
• Evaluation of antimicrobial and lipopolysaccharide-neutralizing effects of a synthetic CAP18 fragment against Pseudomonas aeruginosa in a mouse model.
  Antimicrobial agents and chemotherapy 1998 Sawa T, Kurahashi K, Ohara M, Gropper MA, Doshi V, Larrick JW, Wiener-Kronish JP
• In vitro cellular toxicity predicts Pseudomonas aeruginosa virulence in lung infections.
  Infection and immunity 1998 Sawa T, Ohara M, Kurahashi K, Twining SS, Frank DW, Doroques DB, Long T, Gropper MA, Wiener-Kronish JP
• Halogenated anesthetics and the injured lung: clouds on the horizon?
  Anesthesiology 1998 Wiener-Kronish JP, Gropper MA
• Induction of cyclooxygenase-2 in alveolar macrophages after acid aspiration: selective cyclooxygenase-2 blockade reduces interleukin-6 production.
  Anesthesiology 1998 Ohara M, Sawa T, Kurahashi K, Wiener-Kronish JP, Doshi V, Kudoh I, Gropper MA
• IL-10 improves lung injury and survival in Pseudomonas aeruginosa pneumonia.
  Journal of immunology (Baltimore, Md. : 1950) 1997 Sawa T, Corry DB, Gropper MA, Ohara M, Kurahashi K, Wiener-Kronish JP
• Quantitative analysis of aquaporin mRNA expression in rat tissues by RNase protection assay.
  DNA and cell biology 1996 Umenishi F, Verkman AS, Gropper MA
• Intraluminal water increases expression of plasmid DNA in rat lung.
  Human gene therapy 1996 Sawa T, Miyazaki H, Pittet JF, Widdicombe JH, Gropper MA, Hashimoto S, Conrad DJ, Folkesson HG, Debs R, Forsayeth JR, Fox B, Wiener-Kronish JP
• Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues.
  Journal of cell science 1995 Frigeri A, Gropper MA, Umenishi F, Kawashima M, Brown D, Verkman AS
• Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes.
  Proceedings of the National Academy of Sciences of the United States of America 1995 Frigeri A, Gropper MA, Turck CW, Verkman AS
• Acute cardiogenic pulmonary edema.
  Clinics in chest medicine 1994 Gropper MA, Wiener-Kronish JP, Hashimoto S
• Pulmonary arterial and venous constriction during hypoxia in 3- to 5-wk-old and adult ferrets.
  Journal of applied physiology (Bethesda, Md. : 1985) 1990 Raj JU, Hillyard R, Kaapa P, Gropper M, Anderson J
• The adult respiratory distress syndrome: definition and prognosis, pathogenesis and treatment.
  British journal of anaesthesia 1990 Wiener-Kronish JP, Gropper MA, Matthay MA
• [Estimation of the filtration variables in the rat lung].
  Nihon Kyobu Shikkan Gakkai zasshi 1989 Tanita T, Gropper MA, Staub NC, Koike K, Nakada T
• Lung expansion and the perialveolar interstitial pressure gradient.
  Journal of applied physiology (Bethesda, Md. : 1985) 1989 Bhattacharya J, Gropper MA, Shepard JM
• Relationship of pleural effusions to increased permeability pulmonary edema in anesthetized sheep.
  The Journal of clinical investigation 1988 Wiener-Kronish JP, Broaddus VC, Albertine KH, Gropper MA, Matthay MA, Staub NC
• Alveolar liquid and protein clearance from normal dog lungs.
  Journal of applied physiology (Bethesda, Md. : 1985) 1988 Berthiaume Y, Broaddus VC, Gropper MA, Tanita T, Matthay MA
• Filtration profile in isolated zone 1 and zone 3 dog lungs at constant high alveolar pressure.
  Journal of applied physiology (Bethesda, Md. : 1985) 1988 Gropper MA, Bhattacharya J, Staub NC
• Lung microvascular pressure profile measured by micropuncture in anesthetized dogs.
  Journal of applied physiology (Bethesda, Md. : 1985) 1988 Shepard JM, Gropper MA, Nicolaysen G, Staub NC, Bhattacharya J
• Direct measurement of blood pressure within the long hypophysial portal blood vessels.
  Neuroendocrinology 1987 Findell PR, Mulchahey JJ, Shepard JM, Gropper MA, Battacharya J, Weiner RI
• Pleural liquid pressure in dogs measured using a rib capsule.
  Journal of applied physiology (Bethesda, Md. : 1985) 1985 Wiener-Kronish JP, Gropper MA, Lai-Fook SJ
• Interstitial fluid pressure gradient measured by micropuncture in excised dog lung.
  Journal of applied physiology: respiratory, environmental and exercise physiology 1984 Bhattacharya J, Gropper MA, Staub NC
• Micropuncture measurement of lung microvascular pressure profile during hypoxia in cats.
  Circulation research 1984 Nagasaka Y, Bhattacharya J, Nanjo S, Gropper MA, Staub NC
• Effect of lung inflation on alveolar-airway barrier protein permeability in dog lung.
  Journal of applied physiology: respiratory, environmental and exercise physiology 1983 Conhaim RL, Gropper MA, Staub NC