Michael Dae, MD
Professor Emeritus
Radiology
School of Medicine

Currently, he leads an initiative to increase clinical utilization of cardiac positron emission tomographic imaging (PET) for patients to provide better diagnostic imaging with less radiation exposure, and greater patient experience.

As a research focus, Dr. Dae and his colleagues have developed extensive experience with radionuclide assessment of myocardial sympathetic innervation. They evaluate the ability of MIBG to map sympathetic innervation in various experimental models of cardiac disease, and have characterized the physiologic and electro physiologic consequences of abdominal uptake and distribution of the tracer. Also, Dr. Dae and his colleagues have extensive experience in the pre-clinical and clinical assessment of new medical devices in cardiovascular medicine, ranging from assessment of prototypes to the completion of GLP studies for FDA submissions.

Dr. Dae has published and written 93 articles, 27 book chapters, and 6 significant publications. He is responsible for conceiving studies, assisting with trail designs, supervising performances, and designing imaging aspects of the experiments.

Expertise: Nuclear Medicine

Specialty: Nuclear cardiology

Professional Interests: Development of a noninvasive approach to treat acute and chronic kidney disease

Education and Training:

• Medical School: Duke University, Durham, North Carolina - Medicine
• Internship: Children’s Hospital, Boston, Massachusetts - Pediatrics
• Residency: Children’s Hospital, Boston, Massachusetts - Pediatrics
• Residency: University of California, San Francisco - Nuclear Medicine, Chief Resident
• Fellowship: University of California, San Francisco - Pediatric Cardiology
• Fellowship: University of California, San Francisco - Nuclear Cardiology
• Master of Business Administration: University of San Francisco - Business
• Diplomate, National Board of Medical Examiners
• California License
• American Board of Pediatrics
• American Board of Nuclear Medicine
• Certified - Advanced Cardiac Life Support
• Certified - Basic Life Support
• Level 2 Certification for Competency in Cardiac CT
• Certificate of Proficiency - PET/CT - American College of Radiology
• Certified - Advanced Cardiac Life Support

• Automatic TAC extraction from dynamic cardiac PET imaging using iterative correlation from a population template.
  Computer methods and programs in biomedicine 2013 Mateos-Pérez JM, Desco M, Dae MW, García-Villalba C, Cussó L, Vaquero JJ
• Approach to assessing myocardial perfusion in rats using static [13N]-ammonia images and a small-animal PET.
  Molecular imaging and biology 2012 Vaquero JJ, Gao DW, García-Villaba C, Bacharach S, Vanbrocklin H, Fang Q, Desco M, Lee R, Dae M
• Combining dynamic and ECG-gated ⁸²Rb-PET for practical implementation in the clinic.
  Nuclear medicine communications 2012 Sayre GA, Bacharach SL, Dae MW, Seo Y
• Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarction.
  PloS one 2010 Mihardja SS, Gao D, Sievers RE, Fang Q, Feng J, Wang J, Vanbrocklin HF, Larrick JW, Huang M, Dae M, Lee RJ
• Percutaneous implantation of an intraventricular device for the treatment of heart failure: experimental results and proof of concept.
  Journal of cardiac failure 2009 Nikolic SD, Khairkhahan A, Ryu M, Champsaur G, Breznock E, Dae M
• The relationship of myocardial contraction and electrical excitation--the correlation between scintigraphic phase image analysis and electrophysiologic mapping.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2009 del Romeral LM, Stillson C, Lesh M, Dae M, Botvinick E
• Localization of ventricular tachycardia exit site and subsequent contraction sequence and functional effects with bedside radionuclide angiography.
  JACC. Cardiovascular imaging 2008 Botvinick E, Davis J, Dae M, O'Connell J, Schechtmann N, Abbott J, Morady F, Lanzer P, Iskikian J, Scheinman M
• Pediatric nuclear cardiology.
  Seminars in nuclear medicine 2007 Dae MW
• Rodent brain imaging with SPECT/CT.
  Medical physics 2007 Seo Y, Gao DW, Hasegawa BH, Dae MW, Franc BL
• Prospective analysis of prevalence, distribution, and rate of recovery of left ventricular systolic dysfunction in patients with subarachnoid hemorrhage.
  Journal of neurosurgery 2006 Banki N, Kopelnik A, Tung P, Lawton MT, Gress D, Drew B, Dae M, Foster E, Parmley W, Zaroff J
• Left ventricular apex occluder. Description of a Ventricular Partitioning Device.
  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 2006 Sharkey H, Nikolic S, Khairkhahan A, Dae M
• Acute neurocardiogenic injury after subarachnoid hemorrhage.
  Circulation 2005 Banki NM, Kopelnik A, Dae MW, Miss J, Tung P, Lawton MT, Drew BJ, Foster E, Smith W, Parmley WW, Zaroff JG
• Age and aneurysm position predict patterns of left ventricular dysfunction after subarachnoid hemorrhage.
  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2005 Khush K, Kopelnik A, Tung P, Banki N, Dae M, Lawton M, Smith W, Drew B, Foster E, Zaroff J
• Combined effects of mild hypothermia and glycoprotein IIb/IIIa antagonists on platelet-platelet and leukocyte-platelet aggregation.
  The American journal of cardiology 2003 Frelinger AL, Furman MI, Barnard MR, Krueger LA, Dae MW, Michelson AD
• Hypothermia during reperfusion limits 'no-reflow' injury in a rabbit model of acute myocardial infarction.
  Cardiovascular research 2003 Hale SL, Dae MW, Kloner RA
• Pinhole single-photon emission computed tomography for myocardial perfusion imaging of mice.
  Journal of the American College of Cardiology 2003 Wu MC, Gao DW, Sievers RE, Lee RJ, Hasegawa BH, Dae MW
• Safety and efficacy of endovascular cooling and rewarming for induction and reversal of hypothermia in human-sized pigs.
  Stroke 2003 Dae MW, Gao DW, Ursell PC, Stillson CA, Sessler DI
• Induction of mild systemic hypothermia with endovascular cooling during primary percutaneous coronary intervention for acute myocardial infarction.
  Journal of the American College of Cardiology 2002 Dixon SR, Whitbourn RJ, Dae MW, Grube E, Sherman W, Schaer GL, Jenkins JS, Baim DS, Gibbons RJ, Kuntz RE, Popma JJ, Nguyen TT, O'Neill WW
• Performance evaluation of a pinhole SPECT system for myocardial perfusion imaging of mice.
  Medical physics 2002 Wu MC, Hasegawa BH, Dae MW
• Effect of endovascular cooling on myocardial temperature, infarct size, and cardiac output in human-sized pigs.
  American journal of physiology. Heart and circulatory physiology 2002 Dae MW, Gao DW, Sessler DI, Chair K, Stillson CA
• Effect of endomyocardial laser channels on regional innervation shown with (125)I-MIBG and autoradiography.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2002 Johnson LL, Thambar S, Donahay T, Dae M, Williams DO
• Buspirone and meperidine synergistically reduce the shivering threshold.
  Anesthesia and analgesia 2001 Mokhtarani M, Mahgoub AN, Morioka N, Doufas AG, Dae M, Shaughnessy TE, Bjorksten AR, Sessler DI
• Effects of reduced sympathetic activity on myocardial metaiodobenzylguanidine (MIBG) washout.
  Journal of autonomic pharmacology 2001 Gao DW, Talke PO, Dae MW
• Absolute quantification of regional myocardial uptake of 99mTc-sestamibi with SPECT: experimental validation in a porcine model.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2001 Da Silva AJ, Tang HR, Wong KH, Wu MC, Dae MW, Hasegawa BH
• Reperfused rat myocardium subjected to various durations of ischemia: estimation of the distribution volume of contrast material with echo-planar MR imaging.
  Radiology 2000 Arheden H, Saeed M, Higgins CB, Gao DW, Ursell PC, Bremerich J, Wyttenbach R, Dae MW, Wendland MF
• Long-term estrogen replacement therapy is associated with improved exercise capacity in postmenopausal women without known coronary artery disease.
  American heart journal 2000 Redberg RF, Nishino M, McElhinney DB, Dae MW, Botvinick EH
• Heterogeneous sympathetic innervation influences local myocardial repolarization in normally perfused rabbit hearts.
  Circulation 2000 Yoshioka K, Gao DW, Chin M, Stillson C, Penades E, Lesh M, O'Connell W, Dae M
• Impact of a home-based walking and resistance training program on quality of life in patients with heart failure.
  The American journal of cardiology 2000 Oka RK, De Marco T, Haskell WL, Botvinick E, Dae MW, Bolen K, Chatterjee K
• Measurement of the distribution volume of gadopentetate dimeglumine at echo-planar MR imaging to quantify myocardial infarction: comparison with 99mTc-DTPA autoradiography in rats.
  Radiology 1999 Arheden H, Saeed M, Higgins CB, Gao DW, Bremerich J, Wyttenbach R, Dae MW, Wendland MF
• Microvascular injury in reperfused infarcted myocardium: noninvasive assessment with contrast-enhanced echoplanar magnetic resonance imaging.
  Journal of the American College of Cardiology 1998 Bremerich J, Wendland MF, Arheden H, Wyttenbach R, Gao DW, Huberty JP, Dae MW, Higgins CB, Saeed M
• Is there any advantage to the acquisition of 24-hour thallium images, in the presence of persistent perfusion defects at 4 h after reinjection?
  European journal of nuclear medicine 1998 Bobba K, Botvinick EH, Sciammarella MG, Starsken NF, Zhu YY, Lapidus A, Dae MW
• Potential added value of three-dimensional reconstruction and display of single photon emission computed tomographic gated blood pool images.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1998 Botvinick EH, O'Connell JW, Kadkade PP, Glickman SL, Dae MW, Cohen TJ, Abbott J, Krishnan R
• Toward necrotic cell fraction measurement by contrast-enhanced MRI of reperfused ischemically injured myocardium.
  Academic radiology 1998 Wendland MF, Saeed M, Arheden H, Gao DW, Canet E, Bremerich J, Dae MW, Higgins CB
• Nonperfusion applications in nuclear cardiology: report of a task force of the American Society of Nuclear Cardiology.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1998 DePuey EG, Port S, Wackers FJ, Rozanski A, Botvinick EH, Dae MW, Tamaki N
• Myocardial perfusion imaging with a combined x-ray CT and SPECT system.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1997 Kalki K, Blankespoor SC, Brown JK, Hasegawa BH, Dae MW, Chin M, Stillson C
• Fast acquisition of myocardial SPECT images with Tc-99m sestamibi for the diagnosis of coronary artery disease.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1997 Segall GM, Stepp C, Kadkade PP, Dae MW, Botvinick EH
• Heterogeneous sympathetic innervation in German shepherd dogs with inherited ventricular arrhythmia and sudden cardiac death.
  Circulation 1997 Dae MW, Lee RJ, Ursell PC, Chin MC, Stillson CA, Moise NS
• Deconvolution: a novel signal processing approach for determining activation time from fractionated electrograms and detecting infarcted tissue.
  Circulation 1996 Ellis WS, Eisenberg SJ, Auslander DM, Dae MW, Zakhor A, Lesh MD
• Acute and chronic effects of transient myocardial ischemia on sympathetic nerve activity, density, and norepinephrine content.
  Cardiovascular research 1995 Dae MW, O'Connell JW, Botvinick EH, Chin MC
• Metaiodobenzylguanidine as an index of atrioventricular nodal adrenergic activity.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995 Lurie KG, Dae MW, Dutton J, Velazquez-Rocha SJ, O'Connell JW
• Variability of normal coronary anatomy: implications for the interpretation of thallium-SPECT myocardial perfusion images in single-vessel disease.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995 Segall GM, Atwood JE, Botvinick EH, Dae MW, Lucas JR
• Iodine-123 metaiodobenzylguanidine scintigraphic assessment of the transplanted human heart: evidence for late reinnervation.
  Journal of the American College of Cardiology 1995 De Marco T, Dae M, Yuen-Green MS, Kumar S, Sudhir K, Keith F, Amidon TM, Rifkin C, Klinski C, Lau D
• Scintigraphy of myocardial innervation with metaiodobenzylguanidine (MIBG): is there a clinical application?
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1995 Dae MW
• Segmental analysis of resting echocardiographic function and stress scintigraphic perfusion: implications for myocardial viability.
  American heart journal 1995 Foster E, O'Kelly B, LaPidus A, Sandler D, Tucker K, Dae M, Schiller NB, Botvinick EH
• Effects of long-term right ventricular apical pacing on left ventricular perfusion, innervation, function and histology.
  Journal of the American College of Cardiology 1994 Lee MA, Dae MW, Langberg JJ, Griffin JC, Chin MC, Finkbeiner WE, O'Connell JW, Botvinick E, Scheinman MM, Rosenqvist M
• Does myocardial perfusion scintigraphy demonstrate clinical usefulness in patients with markedly positive exercise tests? An assessment of the method in a high-risk subset.
  American heart journal 1994 Krishnan R, Lu J, Dae MW, Botvinick EH
• Imaging of myocardial sympathetic innervation with metaiodobenzylguanidine.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1994 Dae MW
• Assessment of perfused left ventricular mass in normal, ischemic, and reperfused myocardium by means of single-photon emission computed tomography of technetium-99m isonitrile.
  American heart journal 1993 Wolfe CL, O'Connell JW, Sievers RE, Cobb C, Dae MW, Botvinick E
• Comparison of T1-enhancing and magnetic susceptibility magnetic resonance contrast agents for demarcation of the jeopardy area in experimental myocardial infarction.
  Investigative radiology 1993 Yu KK, Saeed M, Wendland MF, Dae MW, Velasquez-Rocha S, Derugin N, Higgins CB
• Effects of canine myocardial infarction on sympathetic efferent neuronal function: scintigraphic and electrophysiologic correlates.
  American heart journal 1993 Newman D, Munoz L, Chin M, Franz M, Herre J, Scheinman MM, Botvinick E, Dae M
• Hypertrophic cardiomyopathy in the young: another form of ischemic cardiomyopathy?
  Journal of the American College of Cardiology 1993 Botvinick EH, Dae MW, Krishnan R, Ewing S
• Myocardial perfusion scintigraphy in left bundle branch block: a perspective on the issue from image analysis in a clinical context.
  American heart journal 1993 Krishnan R, Lu J, Zhu YY, Dae MW, Botvinick EH
• Myocardial viability: evidence provided by the analysis of left ventricular systolic function.
  Coronary artery disease 1993 Lucas JR, Botvinick EH, Dae MW
• Basal interventricular septal thallium-201 defects: real or artifact?
  Clinical nuclear medicine 1993 Starksen NF, O'Connell W, Dae MW, Botvinick EH
• A quantitative assessment of patient motion and its effect on myocardial perfusion SPECT images.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1993 Botvinick EH, Zhu YY, O'Connell WJ, Dae MW
• Diagnostic and prognostic value of ambulatory electrocardiographic monitoring.
  American heart journal 1992 Munoz del Romeral L, Dae MW, Ports TA, Botvinick EH
• A unique finding on I-123 MIBG imaging: pericardial effusion.
  Clinical nuclear medicine 1992 Fischbein NJ, Dae MW, Sandler ED
• Scintigraphic assessment of MIBG uptake in globally denervated human and canine hearts--implications for clinical studies.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992 Dae MW, De Marco T, Botvinick EH, O'Connell JW, Hattner RS, Huberty JP, Yuen-Green MS
• Comparison of the findings on preoperative dipyridamole perfusion scintigraphy and intraoperative transesophageal echocardiography: implications regarding the identification of myocardium at ischemic risk.
  Journal of the American College of Cardiology 1991 Watters TA, Botvinick EH, Dae MW, Cahalan M, Urbanowicz J, Benefiel DJ, Schiller NB, Goldstone G, Reilly L, Stoney RJ
• Dipyridamole perfusion scintigraphy.
  Seminars in nuclear medicine 1991 Botvinick EH, Dae MW
• Phase image triangulation of accessory pathways in patients undergoing catheter ablation of posteroseptal pathways.
  Pacing and clinical electrophysiology : PACE 1991 Oeff M, Scheinman MM, Abbott JA, Botvinick EH, Griffin JC, Herre JM, Dae MW
• Scintigraphic assessment of sympathetic innervation after transmural versus nontransmural myocardial infarction.
  Journal of the American College of Cardiology 1991 Dae MW, Herre JM, O'Connell JW, Botvinick EH, Newman D, Munoz L
• Relative importance of activation sequence compared to atrioventricular synchrony in left ventricular function.
  The American journal of cardiology 1991 Rosenqvist M, Isaaz K, Botvinick EH, Dae MW, Cockrell J, Abbott JA, Schiller NB, Griffin JC
• Dipyridamole perfusion scintigraphy: the experience with its application in one hundred seventy patients with known or suspected unstable angina.
  American heart journal 1991 Zhu YY, Chung WS, Botvinick EH, Dae MW, Lim AD, Ports TA, Danforth JW, Wolfe CL, Goldschlager N, Chatterjee K
• Imaging of the heart using metaiodobenzylguanidine.
  Journal of thoracic imaging 1990 Dae MW, Botvinick EH
• Comparison of transesophageal echocardiographic and scintigraphic estimates of left ventricular end-diastolic volume index and ejection fraction in patients following coronary artery bypass grafting.
  Anesthesiology 1990 Urbanowicz JH, Shaaban MJ, Cohen NH, Cahalan MK, Botvinick EH, Chatterjee K, Schiller NB, Dae MW, Matthay MA
• Blood pool scintigraphy.
  Cardiology clinics 1989 Botvinick EH, Dae MW, O'Connell JW
• Neonatal model of heterotopic heart transplantation in pigs.
  The Journal of thoracic and cardiovascular surgery 1989 Verrier ED, Crombleholme TM, Sauer L, Longaker M, Langer JC, Flake AW, Dae M, Brem H, Harrison MR
• ECG left anterior fascicular block reveals diverse patterns on scintigraphic phase analysis.
  American heart journal 1989 Dae M, Wen YM, Botvinick EH, Scheinman M
• The scintigraphic characteristics of ventricular pre-excitation through Mahaim fibers with the use of phase analysis.
  Journal of the American College of Cardiology 1989 Schechtmann N, Botvinick EH, Dae M, Scheinman MM, O'Connell JW, Davis J, Winston S, Schwartz A, Abbott J
• Scintigraphic assessment of regional cardiac adrenergic innervation.
  Circulation 1989 Dae MW, O'Connell JW, Botvinick EH, Ahearn T, Yee E, Huberty JP, Mori H, Chin MC, Hattner RS, Herre JM
• The clinical and pathophysiologic implications of pain, ST abnormalities, and scintigraphic changes induced during dipyridamole infusion: their relationships to the peripheral hemodynamic response.
  American heart journal 1988 Zhu YY, Lee W, Botvinick E, Dae M, Chatterjee K, Danforth J, Ports T
• Gallium lung scintigraphy in amiodarone pulmonary toxicity.
  Chest 1988 Zhu YY, Botvinick E, Dae M, Golden J, Hattner R, Scheinman M
• Dipyridamole myocardial perfusion scintigraphy.
  The Western journal of medicine 1988 Botvinick EH, Dae M
• Analysis of thallium-201 "washout" from parametric color coded images.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1988 Botvinick EH, O'Connell WJ, Dae MW, Hattner RS, Schechtmann NM
• Effect of transmural versus nontransmural myocardial infarction on inducibility of ventricular arrhythmias during sympathetic stimulation in dogs.
  Journal of the American College of Cardiology 1988 Herre JM, Wetstein L, Lin YL, Mills AS, Dae M, Thames MD
• Augmented preexcitation assessed by scintigraphic phase analysis during atrial pacing.
  American heart journal 1987 Botvinick E, Schechtmann N, Dae M, Scheinman M, Davis J, Herre J, Iskikian T, Abbott J
• Hemodynamic and clinical evaluation of piroximone, a new inotrope-vasodilator agent, in severe congestive heart failure.
  Journal of the American College of Cardiology 1987 Axelrod RJ, De Marco T, Dae M, Botvinick EH, Chatterjee K
• Quantitation of mitral regurgitation by Doppler echocardiography.
  Circulation 1986 Blumlein S, Bouchard A, Schiller NB, Dae M, Byrd BF, Ports T, Botvinick EH
• Interaction of "supplementary" scintigraphic indicators of ischemia and stress electrocardiography in the diagnosis of multivessel coronary disease.
  Journal of the American College of Cardiology 1985 Canhasi B, Dae M, Botvinick E, Lanzer P, Schechtmann N, Faulkner D, O'Connell W, Schiller N
• The effects of coronary angioplasty and reperfusion on distribution of myocardial flow.
  Circulation 1985 Wahr DW, Ports TA, Botvinick EH, Dae M, Schechtmann N, Huberty J, Hattner RS, O'Connell JW, Turley K
• Undrained bloody pericardial effusion in the early postoperative period after coronary bypass surgery: a prospective blood pool study.
  American heart journal 1985 Viquerat CE, Hansen RM, Botvinick EH, Dae MW, Wiener-Kronish JP, Matthay MA
• The etiology and implications of dense cavitary "photopenia" on myocardial perfusion scintigraphy.
  Investigative radiology 1985 Dae M, Canhasi B, Botvinick E, Olvera S, Schechtmann N, Engelstad B, Hattner R, Schiller N, O'Connell W, Faulkner D
• Phase image characterization of localized and generalized left ventricular contraction abnormalities.
  Journal of the American College of Cardiology 1984 Frais M, Botvinick E, Shosa D, O'Connell W, Pacheco Alvarez J, Dae M, Hattner R, Faulkner D
• Phase image evaluation of patients with ventricular pre-excitation syndromes.
  Journal of the American College of Cardiology 1984 Botvinick E, Frais M, O'Connell W, Faulkner D, Scheinman M, Morady F, Sung R, Shosa D, Dae M
• Characterization of conduction and concentration abnormalities by scintigraphic phase analysis.
  International journal of cardiology 1984 Dae MW, Botvinick EH