Michael Boucher, PhD
Postdoctoral Scholar
Biochemistry and Biophysics
School of Medicine

Education & Training

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• PhD Microbiology & Immunology Stanford University 01/2019
• BS Biochemistry & Molecular Biology University of Massachusetts Amherst 05/2013
• BS Microbiology University of Massachusetts Amherst 05/2013

Grants and Projects

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• Mechanisms of immune evasion by a neuroinvasive fungal pathogen, NIH, 2021-2023

Publications (9)

Top publication keywords:
AntimalarialsPlastidsPlasmodium falciparumApicoplastsApicomplexaProteomeTrypanosoma brucei bruceiProtozoan ProteinsComputational BiologyProteomicsCryptococcus neoformansIntracellular MembranesOrganelle BiogenesisParasitesMalaria

• Convergent evolution of innate immune-modulating effectors in invasive fungal pathogens.
  Trends in microbiology 2023 Boucher MJ, Madhani HD
• Short homology-directed repair using optimized Cas9 in the pathogen Cryptococcus neoformans enables rapid gene deletion and tagging.
  Genetics 2022 Huang MY, Joshi MB, Boucher MJ, Lee S, Loza LC, Gaylord EA, Doering TL, Madhani HD
• Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery.
  Journal of medicinal chemistry 2021 Kryštufek R, Šácha P, Starková J, Brynda J, Hradilek M, Tloušt'ová E, Grzymska J, Rut W, Boucher MJ, Drag M, Majer P, Hájek M, Rezácová P, Madhani HD, Craik CS, Konvalinka J
• A DNA polymerization-independent role for mitochondrial DNA polymerase I-like protein C in African trypanosomes.
  Journal of cell science 2020 Miller JC, Delzell SB, Concepción-Acevedo J, Boucher MJ, Klingbeil MM
• The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites.
  Cell chemical biology 2020 Yoo E, Schulze CJ, Stokes BH, Onguka O, Yeo T, Mok S, Gnädig NF, Zhou Y, Kurita K, Foe IT, Terrell SM, Boucher MJ, Cieplak P, Kumpornsin K, Lee MCS, Linington RG, Long JZ, Uhlemann AC, Weerapana E, …

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• Plastid-endomembrane connections in apicomplexan parasites.
  PLoS pathogens 2019 Boucher MJ, Yeh E
• Disruption of Apicoplast Biogenesis by Chemical Stabilization of an Imported Protein Evades the Delayed-Death Phenotype in Malaria Parasites.
  mSphere 2019 Boucher MJ, Yeh E
• Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites.
  PLoS biology 2018 Boucher MJ, Ghosh S, Zhang L, Lal A, Jang SW, Ju A, Zhang S, Wang X, Ralph SA, Zou J, Elias JE, Yeh E
• Cell cycle localization dynamics of mitochondrial DNA polymerase IC in African trypanosomes.
  Molecular biology of the cell 2018 Concepción-Acevedo J, Miller JC, Boucher MJ, Klingbeil MM