Michael Beattie, PhD
Professor
Neurological Surgery
School of Medicine

Preclinical and translational research in CNS injury and repair, including studies of the cell biology of injury and repair, development of preclinical models of brain and spinal cord injury, pharmacological and transplantation approaches to improving outcomes after CNS trauma, and applications to human spinal cord injury.

Awards

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• Reeve-Irvine Research Medal in SCI, UC Irvine, 2012

Education & Training

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• Ph.D. Neuroscience The Ohio State University 1977
• B.S. Biological Psychology UC Davis 1972

Websites

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• Profile at UCSF Neurosurgery (neurosurgery.ucsf.edu)

Grants and Projects

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• Translational Outcomes Project: Visualizing Syndromic Information and Outcomes for Neurotrauma (TOP-VISION), NIH, 2018-2023
• Embryonic stem cell therapy after cervical contusion SCI in NHPs, NIH, 2017-2022
• Peripheral blood RNA biomarkers of recovery after spinal cord injury, NIH, 2018-2021
• The Role of the p75ntr in immune cell differentiation and trafficking in traumatic brain injury (TBI), NIH, 2019-2021
• Translational Outcomes Project: Visualizing Syndromic Information and Outcomes for Neurotrauma (TOP-VISION), NIH, 2018-2020
• Plasticity and Regeneration in the Primate Spinal Cord, NIH, 2001-2018
• Mechanisms of secondary injury after SCI, NIH, 1999-2017
• Cervical spinal injury and demyelination in aged rats, NIH, 2009-2012
• Recovery of sacral spinal reflexes after transplantation, NIH, 1994-2009
• Neural Development, Plasticity &Regeneration, NIH, 1989-2001
• Video Image Analysis for Neural and Cell Biology, NIH, 1986-1987

Publications (161)

Top publication keywords:
PiperazinesReceptors, AMPAContusionsRecovery of FunctionCervical VertebraeSpinal Cord InjuriesRatsSpinal CordTumor Necrosis Factor-alphaArterial PressureRats, Long-EvansPenile ErectionOligodendrogliaNeuronal PlasticityReceptor, Nerve Growth Factor

• Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury.
  Scientific reports 2021 Huie JR, Ferguson AR, Kyritsis N, Pan JZ, Irvine KA, Nielson JL, Schupp PG, Oldham MC, Gensel JC, Lin A, Segal MR, Ratan RR, Bresnahan JC, Beattie MS
• Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics.
  Neurosurgical focus 2020 Tsolinas RE, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris MH, Yue JK, Winkler EA, Suen CG, Pascual LU, Ferguson AR, Huie JR, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, …
• Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury.
  Nature neuroscience 2019 Rosenzweig ES, Salegio EA, Liang JJ, Weber JL, Weinholtz CA, Brock JH, Moseanko R, Hawbecker S, Pender R, Cruzen CL, Iaci JF, Caggiano AO, Blight AR, Haenzi B, Huie JR, Havton LA, Nout-Lomas YS, …
• Restorative effects of human neural stem cell grafts on the primate spinal cord.
  Nature medicine 2018 Rosenzweig ES, Brock JH, Lu P, Kumamaru H, Salegio EA, Kadoya K, Weber JL, Liang JJ, Moseanko R, Hawbecker S, Huie JR, Havton LA, Nout-Lomas YS, Ferguson AR, Beattie MS, Bresnahan JC, Tuszynski MH
• A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury.
  Journal of neuroinflammation 2016 Lee S, Mattingly A, Lin A, Sacramento J, Mannent L, Castel MN, Canolle B, Delbary-Gossart S, Ferzaz B, Morganti JM, Rosi S, Ferguson AR, Manley GT, Bresnahan JC, Beattie MS
• A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury.
  Brain : a journal of neurology 2016 Delbary-Gossart S, Lee S, Baroni M, Lamarche I, Arnone M, Canolle B, Lin A, Sacramento J, Salegio EA, Castel MN, Delesque-Touchard N, Alam A, Laboudie P, Ferzaz B, Savi P, Herbert JM, Manley GT, …
• A Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates (Macaca mulatta).
  Journal of neurotrauma 2016 Salegio EA, Bresnahan JC, Sparrey CJ, Camisa W, Fischer J, Leasure J, Buckley J, Nout-Lomas YS, Rosenzweig ES, Moseanko R, Strand S, Hawbecker S, Lemoy MJ, Haefeli J, Ma X, Nielson JL, Edgerton VR, …
• Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury.
  Nature communications 2015 Nielson JL, Paquette J, Liu AW, Guandique CF, Tovar CA, Inoue T, Irvine KA, Gensel JC, Kloke J, Petrossian TC, Lum PY, Carlsson GE, Manley GT, Young W, Beattie MS, Bresnahan JC, Ferguson AR
• Combined SCI and TBI: recovery of forelimb function after unilateral cervical spinal cord injury (SCI) is retarded by contralateral traumatic brain injury (TBI), and ipsilateral TBI balances the effects of SCI on paw placement.
  Experimental neurology 2013 Inoue T, Lin A, Ma X, McKenna SL, Creasey GH, Manley GT, Ferguson AR, Bresnahan JC, Beattie MS

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• Safety and comparative efficacy of initiating low-molecular-weight heparin within 24 hours of injury or surgery for venous thromboembolism prophylaxis in patients with spinal cord injury: a prospective TRACK-SCI registry study.
  Neurosurgical focus 2023 Lui A, Park C, Chryssikos T, Radabaugh H, Patel A, Aabedi AA, Ferguson AR, Torres Espin A, Mummaneni PV, Dhall SS, Duong-Fernandez X, Saigal R, Chou A, Pan J, Singh V, Hemmerle DD, Kyritsis N, Talbott…
• Emergence of functionally aberrant and subsequent reduction of neuromuscular connectivity and improved motor performance after cervical spinal cord injury in Rhesus.
  Frontiers in rehabilitation sciences 2023 Wai G, Zdunowski S, Zhong H, Nielson JL, Ferguson AR, Strand SC, Moseanko R, Hawbecker S, Nout-Lomas YS, Rosenzweig ES, Beattie MS, Bresnahan JC, Tuszynski MH, Roy RR, Edgerton VR
• The biomechanical implications of neck position in cervical contusion animal models of SCI.
  Frontiers in neurology 2023 Obaid N, Morioka K, Sinopoulou E, Lomas YN, Salegio E, Bresnahan JC, Beattie MS, Sparrey CJ
• Effect of Impact Parameters on a Unilateral Contusion Model of Spinal Cord Injury in a Virtual Population of Non-Human Primates.
  Neurotrauma reports 2023 Obaid N, Bojic AM, Jannesar S, Salegio E, Nout-Lomas Y, Beattie M, Bresnahan J, Sparrey C
• Hypotension requiring vasopressor treatment and increased cardiac complications in elderly spinal cord injury patients: a prospective TRACK-SCI registry study.
  Journal of neurosurgery. Spine 2023 Agarwal N, Blitstein J, Lui A, Torres-Espin A, Vasnarungruengkul C, Burke J, Mummaneni PV, Dhall SS, Weinstein PR, Duong-Fernandez X, Chou A, Pan J, Singh V, Ferguson AR, Hemmerle DD, Kyritsis N, …
• Rhesus macaque versus rat divergence in the corticospinal projectome.
  Neuron 2022 Sinopoulou E, Rosenzweig ES, Conner JM, Gibbs D, Weinholtz CA, Weber JL, Brock JH, Nout-Lomas YS, Ovruchesky E, Takashima Y, Biane JS, Kumamaru H, Havton LA, Beattie MS, Bresnahan JC, Tuszynski MH
• Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome.
  PloS one 2022 Chou A, Torres-Espin A, Kyritsis N, Huie JR, Khatry S, Funk J, Hay J, Lofgreen A, Shah R, McCann C, Pascual LU, Amorim E, Weinstein PR, Manley GT, Dhall SS, Pan JZ, Bresnahan JC, Beattie MS, Whetstone…
• Empowering Data Sharing and Analytics through the Open Data Commons for Traumatic Brain Injury Research.
  Neurotrauma reports 2022 Chou A, Torres-Espín A, Huie JR, Krukowski K, Lee S, Nolan A, Guglielmetti C, Hawkins BE, Chaumeil MM, Manley GT, Beattie MS, Bresnahan JC, Martone ME, Grethe JS, Rosi S, Ferguson AR
• Decision tree-based machine learning analysis of intraoperative vasopressor use to optimize neurological improvement in acute spinal cord injury.
  Neurosurgical focus 2022 Agarwal N, Aabedi AA, Torres-Espin A, Chou A, Wozny TA, Mummaneni PV, Burke JF, Ferguson AR, Kyritsis N, Dhall SS, Weinstein PR, Duong-Fernandez X, Pan J, Singh V, Hemmerle DD, Talbott JF, Whetstone …
• Appendicular Fracture and Polytrauma Correlate with Outcome of Spinal Cord Injury: A Transforming Research and Clinical Knowledge in Spinal Cord Injury Study.
  Journal of neurotrauma 2022 Miclau TA, Torres-Espin A, Morshed S, Morioka K, Huie JR, El Naga AN, Chou A, Pascual L, Duong-Fernandez X, Kuo YH, Weinstein P, Dhall SS, Bresnahan JC, Beattie MS, Digiorgio A, Ferguson AR, …
• Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury.
  eLife 2021 Torres-Espín A, Haefeli J, Ehsanian R, Torres D, Almeida CA, Huie JR, Chou A, Morozov D, Sanderson N, Dirlikov B, Suen CG, Nielson JL, Kyritsis N, Hemmerle DD, Talbott JF, Manley GT, Dhall SS, …
• Quantifying the kinematic features of dexterous finger movements in nonhuman primates with markerless tracking.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2021 North R, Wurr R, Macon R, Mannion C, Hyde J, Torres-Espin A, Rosenzweig ES, Ferguson AR, Tuszynski MH, Beattie MS, Bresnahan JC, Joiner WM
• Excavating FAIR Data: the Case of the Multicenter Animal Spinal Cord Injury Study (MASCIS), Blood Pressure, and Neuro-Recovery.
  Neuroinformatics 2021 Almeida CA, Torres-Espin A, Huie JR, Sun D, Noble-Haeusslein LJ, Young W, Beattie MS, Bresnahan JC, Nielson JL, Ferguson AR
• Diagnostic blood RNA profiles for human acute spinal cord injury.
  The Journal of experimental medicine 2021 Kyritsis N, Torres-Espín A, Schupp PG, Huie JR, Chou A, Duong-Fernandez X, Thomas LH, Tsolinas RE, Hemmerle DD, Pascual LU, Singh V, Pan JZ, Talbott JF, Whetstone WD, Burke JF, DiGiorgio AM, Weinstein…
• Injury volume extracted from MRI predicts neurologic outcome in acute spinal cord injury: A prospective TRACK-SCI pilot study.
  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2020 Mummaneni N, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris M, Pascual LU, Ferguson AR, Russell Huie J, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Weinstein PR, …
• Correlating Tissue Mechanics and Spinal Cord Injury: Patient-Specific Finite Element Models of Unilateral Cervical Contusion Spinal Cord Injury in Non-Human Primates.
  Journal of neurotrauma 2020 Jannesar S, Salegio EA, Beattie MS, Bresnahan JC, Sparrey CJ
• Correction: Exploration of surgical blood pressure management and expected motor recovery in individuals with traumatic spinal cord injury.
  Spinal cord 2020 Ehsanian R, Haefeli J, Quach N, Kosarchuk J, Torres D, Stuck ED, Endo J, Crew JD, Dirlikov B, Bresnahan JC, Beattie MS, Ferguson AR, McKenna SL
• Correction: Exploration of surgical blood pressure management and expected motor recovery in individuals with traumatic spinal cord injury.
  Spinal cord 2020 Ehsanian R, Haefeli J, Quach N, Kosarchuk J, Torres D, Stuck ED, Endo J, Crew JD, Dirlikov B, Bresnahan JC, Beattie MS, Ferguson AR, McKenna SL
• Exploration of surgical blood pressure management and expected motor recovery in individuals with traumatic spinal cord injury.
  Spinal cord 2019 Ehsanian R, Haefeli J, Quach N, Kosarchuk J, Torres D, Stuck ED, Endo J, Crew JD, Dirlikov B, Bresnahan JC, Beattie MS, Ferguson AR, McKenna SL
• Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury.
  British journal of anaesthesia 2019 Gao J, Sun Z, Xiao Z, Du Q, Niu X, Wang G, Chang YW, Sun Y, Sun W, Lin A, Bresnahan JC, Maze M, Beattie MS, Pan JZ
• Clinical Implementation of Novel Spinal Cord Perfusion Pressure Protocol in Acute Traumatic Spinal Cord Injury at U.S. Level I Trauma Center: TRACK-SCI Study.
  World neurosurgery 2019 Yue JK, Hemmerle DD, Winkler EA, Thomas LH, Fernandez XD, Kyritsis N, Pan JZ, Pascual LU, Singh V, Weinstein PR, Talbott JF, Huie JR, Ferguson AR, Whetstone WD, Manley GT, Beattie MS, Bresnahan JC, …
• Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma.
  Scientific reports 2019 Morioka K, Marmor Y, Sacramento JA, Lin A, Shao T, Miclau KR, Clark DR, Beattie MS, Marcucio RS, Miclau T, Ferguson AR, Bresnahan JC, Bahney CS
• In Reply: Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury.
  Neurosurgery 2019 Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan JZ, Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS
• Incidence and management of diarrhea in patients with HER2-positive breast cancer treated with pertuzumab.
  Annals of oncology : official journal of the European Society for Medical Oncology 2019 Swain SM, Schneeweiss A, Gianni L, Gao JJ, Stein A, Waldron-Lynch M, Heeson S, Beattie MS, Yoo B, Cortes J, Baselga J
• Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury.
  Neurosurgery 2019 Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan JZ, Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS
• Convolutional Neural Network-Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury.
  AJNR. American journal of neuroradiology 2019 McCoy DB, Dupont SM, Gros C, Cohen-Adad J, Huie RJ, Ferguson A, Duong-Fernandez X, Thomas LH, Singh V, Narvid J, Pascual L, Kyritsis N, Beattie MS, Bresnahan JC, Dhall S, Whetstone W, Talbott JF, …
• Value of aggressive surgical and intensive care unit in elderly patients with traumatic spinal cord injury.
  Neurosurgical focus 2019 Lau D, Dalle Ore CL, Tarapore PE, Huang M, Manley G, Singh V, Mummaneni PV, Beattie M, Bresnahan J, Ferguson AR, Talbott JF, Whetstone W, Dhall SS
• MR Imaging for Assessing Injury Severity and Prognosis in Acute Traumatic Spinal Cord Injury.
  Radiologic clinics of North America 2018 Talbott JF, Huie JR, Ferguson AR, Bresnahan JC, Beattie MS, Dhall SS
• Incidence and management of diarrhea in patients with HER2-positive breast cancer treated with pertuzumab.
  Annals of oncology : official journal of the European Society for Medical Oncology 2018 Swain SM, Schneeweiss A, Gianni L, Gao JJ, Stein A, Waldron-Lynch M, Heeson S, Beattie MS, Yoo B, Cortes J, Baselga J
• Motor Evoked Potentials Correlate With Magnetic Resonance Imaging and Early Recovery After Acute Spinal Cord Injury.
  Neurosurgery 2018 Dhall SS, Haefeli J, Talbott JF, Ferguson AR, Readdy WJ, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Whetstone WD
• Considerations and recommendations for selection and utilization of upper extremity clinical outcome assessments in human spinal cord injury trials.
  Spinal cord 2017 Jones LAT, Bryden A, Wheeler TL, Tansey KE, Anderson KD, Beattie MS, Blight A, Curt A, Field-Fote E, Guest JD, Hseih J, Jakeman LB, Kalsi-Ryan S, Krisa L, Lammertse DP, Leiby B, Marino R, Schwab JM, …
• Effect of docetaxel duration on clinical outcomes: exploratory analysis of CLEOPATRA, a phase III randomized controlled trial.
  Annals of oncology : official journal of the European Society for Medical Oncology 2017 Miles D, Im YH, Fung A, Yoo B, Knott A, Heeson S, Beattie MS, Swain SM
• Safety and effectiveness of early chemical deep venous thrombosis prophylaxis after spinal cord injury: pilot prospective data.
  Neurosurgical focus 2017 DiGiorgio AM, Tsolinas R, Alazzeh M, Haefeli J, Talbott JF, Ferguson AR, Bresnahan JC, Beattie MS, Manley GT, Whetstone WD, Mummaneni PV, Dhall SS
• Developing a data sharing community for spinal cord injury research.
  Experimental neurology 2017 Callahan A, Anderson KD, Beattie MS, Bixby JL, Ferguson AR, Fouad K, Jakeman LB, Nielson JL, Popovich PG, Schwab JM, Lemmon VP, FAIR Share Workshop Participants
• Incidence and management of diarrhea in patients with HER2-positive breast cancer treated with pertuzumab.
  Annals of oncology : official journal of the European Society for Medical Oncology 2017 Swain SM, Schneeweiss A, Gianni L, Gao JJ, Stein A, Waldron-Lynch M, Heeson S, Beattie MS, Yoo B, Cortes J, Baselga J
• Multivariate Analysis of MRI Biomarkers for Predicting Neurologic Impairment in Cervical Spinal Cord Injury.
  AJNR. American journal of neuroradiology 2016 Haefeli J, Mabray MC, Whetstone WD, Dhall SS, Pan JZ, Upadhyayula P, Manley GT, Bresnahan JC, Beattie MS, Ferguson AR, Talbott JF
• Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury.
  Neurosurgery 2016 Readdy WJ, Saigal R, Whetstone WD, Mefford AN, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J, Manley GT, Dhall SS
• Higher Mean Arterial Pressure Values Correlate with Neurologic Improvement in Patients with Initially Complete Spinal Cord Injuries.
  World neurosurgery 2016 Catapano JS, John Hawryluk GW, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G
• Mechanical Design and Analysis of a Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates.
  Journal of neurotrauma 2016 Sparrey CJ, Salegio EA, Camisa W, Tam H, Beattie MS, Bresnahan JC
• Diffusion-Weighted Magnetic Resonance Imaging Characterization of White Matter Injury Produced by Axon-Sparing Demyelination and Severe Contusion Spinal Cord Injury in Rats.
  Journal of neurotrauma 2016 Talbott JF, Nout-Lomas YS, Wendland MF, Mukherjee P, Huie JR, Hess CP, Mabray MC, Bresnahan JC, Beattie MS
• Multidimensional Analysis of Magnetic Resonance Imaging Predicts Early Impairment in Thoracic and Thoracolumbar Spinal Cord Injury.
  Journal of neurotrauma 2016 Mabray MC, Talbott JF, Whetstone WD, Dhall SS, Phillips DB, Pan JZ, Manley GT, Bresnahan JC, Beattie MS, Haefeli J, Ferguson AR
• CNS Plasticity in Injury and Disease.
  Neural plasticity 2016 Miller BA, Gensel JC, Beattie MS
• AMPA Receptor Phosphorylation and Synaptic Colocalization on Motor Neurons Drive Maladaptive Plasticity below Complete Spinal Cord Injury.
  eNeuro 2015 Huie JR, Stuck ED, Lee KH, Irvine KA, Beattie MS, Bresnahan JC, Grau JW, Ferguson AR
• Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates.
  Science translational medicine 2015 Friedli L, Rosenzweig ES, Barraud Q, Schubert M, Dominici N, Awai L, Nielson JL, Musienko P, Nout-Lomas Y, Zhong H, Zdunowski S, Roy RR, Strand SC, van den Brand R, Havton LA, Beattie MS, Bresnahan JC…
• Mean Arterial Blood Pressure Correlates with Neurological Recovery after Human Spinal Cord Injury: Analysis of High Frequency Physiologic Data.
  Journal of neurotrauma 2015 Hawryluk G, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G
• Complications and outcomes of vasopressor usage in acute traumatic central cord syndrome.
  Journal of neurosurgery. Spine 2015 Readdy WJ, Whetstone WD, Ferguson AR, Talbott JF, Inoue T, Saigal R, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Dhall SS
• The Brain and Spinal Injury Center score: a novel, simple, and reproducible method for assessing the severity of acute cervical spinal cord injury with axial T2-weighted MRI findings.
  Journal of neurosurgery. Spine 2015 Talbott JF, Whetstone WD, Readdy WJ, Ferguson AR, Bresnahan JC, Saigal R, Hawryluk GW, Beattie MS, Mabray MC, Pan JZ, Manley GT, Dhall SS
• Regulation of axon regeneration by the RNA repair and splicing pathway.
  Nature neuroscience 2015 Song Y, Sretavan D, Salegio EA, Berg J, Huang X, Cheng T, Xiong X, Meltzer S, Han C, Nguyen TT, Bresnahan JC, Beattie MS, Jan LY, Jan YN
• Placental mesenchymal stromal cells rescue ambulation in ovine myelomeningocele.
  Stem cells translational medicine 2015 Wang A, Brown EG, Lankford L, Keller BA, Pivetti CD, Sitkin NA, Beattie MS, Bresnahan JC, Farmer DL
• Large animal and primate models of spinal cord injury for the testing of novel therapies.
  Experimental neurology 2015 Kwon BK, Streijger F, Hill CE, Anderson AJ, Bacon M, Beattie MS, Blesch A, Bradbury EJ, Brown A, Bresnahan JC, Case CC, Colburn RW, David S, Fawcett JW, Ferguson AR, Fischer I, Floyd CL, Gensel JC, …
• Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury.
  Brain research 2014 Nielson JL, Haefeli J, Salegio EA, Liu AW, Guandique CF, Stück ED, Hawbecker S, Moseanko R, Strand SC, Zdunowski S, Brock JH, Roy RR, Rosenzweig ES, Nout-Lomas YS, Courtine G, Havton LA, Steward O, …
• Development of a database for translational spinal cord injury research.
  Journal of neurotrauma 2014 Nielson JL, Guandique CF, Liu AW, Burke DA, Lash AT, Moseanko R, Hawbecker S, Strand SC, Zdunowski S, Irvine KA, Brock JH, Nout-Lomas YS, Gensel JC, Anderson KD, Segal MR, Rosenzweig ES, Magnuson DS, …
• The Irvine, Beatties, and Bresnahan (IBB) Forelimb Recovery Scale: An Assessment of Reliability and Validity.
  Frontiers in neurology 2014 Irvine KA, Ferguson AR, Mitchell KD, Beattie SB, Lin A, Stuck ED, Huie JR, Nielson JL, Talbott JF, Inoue T, Beattie MS, Bresnahan JC
• In utero repair of myelomeningocele with autologous amniotic membrane in the fetal lamb model.
  Journal of pediatric surgery 2013 Brown EG, Saadai P, Pivetti CD, Beattie MS, Bresnahan JC, Wang A, Farmer DL
• Measurement of direct CP violation parameters in B± → J/ψK± and B± → J/ψπ± decays with 10.4 fb-1 of Tevatron data.
  Physical review letters 2013 Abazov VM, Abbott B, Acharya BS, Adams M, Adams T, Agnew JP, Alexeev GD, Alkhazov G, Alton A, Askew A, Atkins S, Augsten K, Avila C, Badaud F, Bagby L, Baldin B, Bandurin DV, Banerjee S, Barberis E, …
• Demonstrating efficacy in preclinical studies of cellular therapies for spinal cord injury - how much is enough?
  Experimental neurology 2013 Kwon BK, Soril LJ, Bacon M, Beattie MS, Blesch A, Bresnahan JC, Bunge MB, Dunlop SA, Fehlings MG, Ferguson AR, Hill CE, Karimi-Abdolrezaee S, Lu P, McDonald JW, Müller HW, Oudega M, Rosenzweig ES, …
• Derivation of multivariate syndromic outcome metrics for consistent testing across multiple models of cervical spinal cord injury in rats.
  PloS one 2013 Ferguson AR, Irvine KA, Gensel JC, Nielson JL, Lin A, Ly J, Segal MR, Ratan RR, Bresnahan JC, Beattie MS
• Human induced pluripotent stem cell-derived neural crest stem cells integrate into the injured spinal cord in the fetal lamb model of myelomeningocele.
  Journal of pediatric surgery 2013 Saadai P, Wang A, Nout YS, Downing TL, Lofberg K, Beattie MS, Bresnahan JC, Li S, Farmer DL
• Glial tumor necrosis factor alpha (TNFα) generates metaplastic inhibition of spinal learning.
  PloS one 2012 Huie JR, Baumbauer KM, Lee KH, Bresnahan JC, Beattie MS, Ferguson AR, Grau JW
• Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair.
  Journal of controlled release : official journal of the Controlled Release Society 2012 Downing TL, Wang A, Yan ZQ, Nout Y, Lee AL, Beattie MS, Bresnahan JC, Farmer DL, Li S
• A quantitative analysis of clinical trial designs in spinal cord injury based on ICCP guidelines.
  Journal of neurotrauma 2012 Sorani MD, Beattie MS, Bresnahan JC
• Animal models of neurologic disorders: a nonhuman primate model of spinal cord injury.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2012 Nout YS, Rosenzweig ES, Brock JH, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Courtine G, Ferguson AR, Edgerton VR, Beattie MS, Bresnahan JC, Tuszynski MH
• Tumor necrosis factor alpha mediates GABA(A) receptor trafficking to the plasma membrane of spinal cord neurons in vivo.
  Neural plasticity 2012 Stück ED, Christensen RN, Huie JR, Tovar CA, Miller BA, Nout YS, Bresnahan JC, Beattie MS, Ferguson AR
• Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey.
  Neurorehabilitation and neural repair 2012 Nout YS, Ferguson AR, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Zhong H, Rosenzweig ES, Brock JH, Courtine G, Edgerton VR, Tuszynski MH, Beattie MS, Bresnahan JC
• Chronic spinal compression model in minipigs: a systematic behavioral, qualitative, and quantitative neuropathological study.
  Journal of neurotrauma 2012 Navarro R, Juhas S, Keshavarzi S, Juhasova J, Motlik J, Johe K, Marsala S, Scadeng M, Lazar P, Tomori Z, Schulteis G, Beattie M, Ciacci JD, Marsala M
• Prenatal repair of myelomeningocele with aligned nanofibrous scaffolds-a pilot study in sheep.
  Journal of pediatric surgery 2011 Saadai P, Nout YS, Encinas J, Wang A, Downing TL, Beattie MS, Bresnahan JC, Li S, Farmer DL
• Spinal cord injury: taking a detour to recovery (Commentary on Schnell et al.).
  The European journal of neuroscience 2011 Bresnahan JC, Beattie MS
• Severity of locomotor and cardiovascular derangements after experimental high-thoracic spinal cord injury is anesthesia dependent in rats.
  Journal of neurotrauma 2011 Nout YS, Beattie MS, Bresnahan JC
• SOD1 overexpression improves features of the oligodendrocyte precursor response in vitro.
  Neuroscience letters 2011 Veiga S, Ly J, Chan PH, Bresnahan JC, Beattie MS
• Tight squeeze, slow burn: inflammation and the aetiology of cervical myelopathy.
  Brain : a journal of neurology 2011 Beattie MS, Manley GT
• A novel method for assessing proximal and distal forelimb function in the rat: the Irvine, Beatties and Bresnahan (IBB) forelimb scale.
  Journal of visualized experiments : JoVE 2010 Irvine KA, Ferguson AR, Mitchell KD, Beattie SB, Beattie MS, Bresnahan JC
• Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury.
  Nature neuroscience 2010 Rosenzweig ES, Courtine G, Jindrich DL, Brock JH, Ferguson AR, Strand SC, Nout YS, Roy RR, Miller DM, Beattie MS, Havton LA, Bresnahan JC, Edgerton VR, Tuszynski MH
• Glial restricted precursor cell transplant with cyclic adenosine monophosphate improved some autonomic functions but resulted in a reduced graft size after spinal cord contusion injury in rats.
  Experimental neurology 2010 Nout YS, Culp E, Schmidt MH, Tovar CA, Pröschel C, Mayer-Pröschel M, Noble MD, Beattie MS, Bresnahan JC
• A grading system to evaluate objectively the strength of pre-clinical data of acute neuroprotective therapies for clinical translation in spinal cord injury.
  Journal of neurotrauma 2010 Kwon BK, Okon EB, Tsai E, Beattie MS, Bresnahan JC, Magnuson DK, Reier PJ, McTigue DM, Popovich PG, Blight AR, Oudega M, Guest JD, Weaver LC, Fehlings MG, Tetzlaff W
• Effects of axon degeneration on oligodendrocyte lineage cells: dorsal rhizotomy evokes a repair response while axon degeneration rostral to spinal contusion induces both repair and apoptosis.
  Glia 2010 Sun F, Lin CL, McTigue D, Shan X, Tovar CA, Bresnahan JC, Beattie MS
• AMPA-receptor trafficking and injury-induced cell death.
  The European journal of neuroscience 2010 Beattie MS, Ferguson AR, Bresnahan JC
• Hypertonic saline attenuates cord swelling and edema in experimental spinal cord injury: a study utilizing magnetic resonance imaging.
  Critical care medicine 2009 Nout YS, Mihai G, Tovar CA, Schmalbrock P, Bresnahan JC, Beattie MS
• Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.
  Annals of the New York Academy of Sciences 2008 Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, Sen C, Beattie MS, Hart RP, Grumet …
• Cell death after spinal cord injury is exacerbated by rapid TNF alpha-induced trafficking of GluR2-lacking AMPARs to the plasma membrane.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Ferguson AR, Christensen RN, Gensel JC, Miller BA, Sun F, Beattie EC, Bresnahan JC, Beattie MS
• Longitudinal comparison of two severities of unilateral cervical spinal cord injury using magnetic resonance imaging in rats.
  Journal of neurotrauma 2008 Mihai G, Nout YS, Tovar CA, Miller BA, Schmalbrock P, Bresnahan JC, Beattie MS
• Developmental stage of oligodendrocytes determines their response to activated microglia in vitro.
  Journal of neuroinflammation 2007 Miller BA, Crum JM, Tovar CA, Ferguson AR, Bresnahan JC, Beattie MS
• Novel technique for monitoring micturition and sexual function in male rats using telemetry.
  American journal of physiology. Regulatory, integrative and comparative physiology 2006 Nout YS, Bresnahan JC, Culp E, Tovar CA, Beattie MS, Schmidt MH
• Kainate induces rapid redistribution of the actin cytoskeleton in ameboid microglia.
  Journal of neuroscience research 2006 Christensen RN, Ha BK, Sun F, Bresnahan JC, Beattie MS
• Alterations in eliminative and sexual reflexes after spinal cord injury: defecatory function and development of spasticity in pelvic floor musculature.
  Progress in brain research 2006 Nout YS, Leedy GM, Beattie MS, Bresnahan JC
• Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats.
  Journal of neurotrauma 2006 Gensel JC, Tovar CA, Hamers FP, Deibert RJ, Beattie MS, Bresnahan JC
• Recommended guidelines for studies of human subjects with spinal cord injury.
  Spinal cord 2005 Anderson DK, Beattie M, Blesch A, Bresnahan J, Bunge M, Dietrich D, Dietz V, Dobkin B, Fawcett J, Fehlings M, Fischer I, Grossman R, Guest J, Hagg T, Hall ED, Houle J, Kleitman N, McDonald J, Murray M…
• A sublethal dose of TNFalpha potentiates kainate-induced excitotoxicity in optic nerve oligodendrocytes.
  Neurochemical research 2005 Miller BA, Sun F, Christensen RN, Ferguson AR, Bresnahan JC, Beattie MS
• Serotonergic fiber sprouting to external anal sphincter motoneurons after spinal cord contusion.
  Experimental neurology 2005 Holmes GM, Van Meter MJ, Beattie MS, Bresnahan JC
• Telemetric monitoring of corpus spongiosum penis pressure in conscious rats for assessment of micturition and sexual function following spinal cord contusion injury.
  Journal of neurotrauma 2005 Nout YS, Schmidt MH, Tovar CA, Culp E, Beattie MS, Bresnahan JC
• Acute transplantation of glial-restricted precursor cells into spinal cord contusion injuries: survival, differentiation, and effects on lesion environment and axonal regeneration.
  Experimental neurology 2004 Hill CE, Proschel C, Noble M, Mayer-Proschel M, Gensel JC, Beattie MS, Bresnahan JC
• Inflammation and apoptosis: linked therapeutic targets in spinal cord injury.
  Trends in molecular medicine 2004 Beattie MS
• A simple post hoc transformation that improves the metric properties of the BBB scale for rats with moderate to severe spinal cord injury.
  Journal of neurotrauma 2004 Ferguson AR, Hook MA, Garcia G, Bresnahan JC, Beattie MS, Grau JW
• TNFalpha-induced AMPA-receptor trafficking in CNS neurons; relevance to excitotoxicity?
  Neuron glia biology 2004 Leonoudakis D, Braithwaite SP, Beattie MS, Beattie EC
• Control of synaptic strength by glial TNFalpha.
  Science (New York, N.Y.) 2002 Beattie EC, Stellwagen D, Morishita W, Bresnahan JC, Ha BK, Von Zastrow M, Beattie MS, Malenka RC
• Dissociation of the effects of nucleus raphe obscurus or rostral ventrolateral medulla lesions on eliminatory and sexual reflexes.
  Physiology & behavior 2002 Holmes GM, Hermann GE, Rogers RC, Bresnahan JC, Beattie MS
• Descending systems contributing to locomotor recovery after mild or moderate spinal cord injury in rats: experimental evidence and a review of literature.
  Restorative neurology and neuroscience 2002 Basso DM, Beattie MS, Bresnahan JC
• Upregulation of the HLH Id gene family in neural progenitors and glial cells of the rat spinal cord following contusion injury.
  Journal of neuroscience research 2001 Tzeng SF, Bresnahan JC, Beattie MS, de Vellis J
• Degeneration and sprouting of identified descending supraspinal axons after contusive spinal cord injury in the rat.
  Experimental neurology 2001 Hill CE, Beattie MS, Bresnahan JC
• Inhibition of pudendal reflexes in spinal rats. Reassessing the role of serotonin.
  Physiology & behavior 2001 Holmes GM, Bresnahan JC, Beattie MS
• Tumor necrosis factor-alpha induces cFOS and strongly potentiates glutamate-mediated cell death in the rat spinal cord.
  Neurobiology of disease 2001 Hermann GE, Rogers RC, Bresnahan JC, Beattie MS
• Intrathecal methiothepin and thyrotropin-releasing hormone effects on penile erection.
  Physiology & behavior 2001 Holmes GM, Stephens RL, Bresnahan JC, Beattie MS
• Review of current evidence for apoptosis after spinal cord injury.
  Journal of neurotrauma 2000 Beattie MS, Farooqui AA, Bresnahan JC
• An analysis of changes in sensory thresholds to mild tactile and cold stimuli after experimental spinal cord injury in the rat.
  Neurorehabilitation and neural repair 2000 Lindsey AE, LoVerso RL, Tovar CA, Hill CE, Beattie MS, Bresnahan JC
• Cell death and plasticity after experimental spinal cord injury.
  Progress in brain research 2000 Beattie MS, Li Q, Bresnahan JC
• Descending projections from the nucleus raphe obscurus to pudendal motoneurons in the male rat.
  The Journal of comparative neurology 1998 Hermann GE, Bresnahan JC, Holmes GM, Rogers RC, Beattie MS
• External anal sphincter hyperreflexia following spinal transection in the rat.
  Journal of neurotrauma 1998 Holmes GM, Rogers RC, Bresnahan JC, Beattie MS
• Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats.
  Journal of neuroscience research 1997 Shuman SL, Bresnahan JC, Beattie MS
• Endogenous repair after spinal cord contusion injuries in the rat.
  Experimental neurology 1997 Beattie MS, Bresnahan JC, Komon J, Tovar CA, Van Meter M, Anderson DK, Faden AI, Hsu CY, Noble LJ, Salzman S, Young W
• Nucleus raphe obscurus (nRO) regulation of anorectal motility in rats.
  Brain research 1997 Holmes GM, Martau JM, Hermann GE, Rogers RC, Bresnahan JC, Beattie MS
• Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys.
  Nature medicine 1997 Crowe MJ, Bresnahan JC, Shuman SL, Masters JN, Beattie MS
• Differential effects of intrathecal thyrotropin-releasing hormone (TRH) on perineal reflexes in male rats.
  Physiology & behavior 1997 Holmes GM, Rogers RC, Bresnahan JC, Beattie MS
• A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth.
  Endocrinology 1996 Otonkoski T, Cirulli V, Beattie M, Mally MI, Soto G, Rubin JS, Hayek A
• MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability. Multicenter Animal Spinal Cord Injury Study.
  Journal of neurotrauma 1996 Basso DM, Beattie MS, Bresnahan JC, Anderson DK, Faden AI, Gruner JA, Holford TR, Hsu CY, Noble LJ, Nockels R, Perot PL, Salzman SK, Young W
• Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection.
  Experimental neurology 1996 Basso DM, Beattie MS, Bresnahan JC
• Trends in pharmacotherapy of Schizoaffective and bipolar affective disorders: a 5-year naturalistic study.
  The American journal of psychiatry 1996 Fenn HH, Robinson D, Luby V, Dangel C, Buxton E, Beattie M, Kraemer H, Yesavage JA
• Thyrotropin-releasing hormone (TRH) and CNS regulation of anorectal motility in the rat.
  Journal of the autonomic nervous system 1995 Holmes GM, Rogers RC, Bresnahan JC, Beattie MS
• Distribution of NADPH-diaphorase reactivity in the spinal cord of metamorphosing and adult Xenopus laevis.
  Brain research. Developmental brain research 1995 Crowe MJ, Brown TJ, Bresnahan JC, Beattie MS
• A sensitive and reliable locomotor rating scale for open field testing in rats.
  Journal of neurotrauma 1995 Basso DM, Beattie MS, Bresnahan JC
• Distribution and morphology of sacral spinal cord neurons innervating pelvic structures in Xenopus laevis.
  The Journal of comparative neurology 1994 Campbell HL, Beattie MS, Bresnahan JC
• Modeling of acute spinal cord injury in the rat: neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673.
  Experimental neurology 1994 Behrmann DL, Bresnahan JC, Beattie MS
• Evidence for alterations of synaptic inputs to sacral spinal reflex circuits after spinal cord transection in the cat.
  Experimental neurology 1993 Beattie MS, Leedy MG, Bresnahan JC
• A comparison of YM-14673, U-50488H, and nalmefene after spinal cord injury in the rat.
  Experimental neurology 1993 Behrmann DL, Bresnahan JC, Beattie MS
• Anatomical and behavioral outcome after spinal cord contusion injury produced by a displacement controlled impact device.
  Restorative neurology and neuroscience 1993 Bresnahan JC, Behrmann DL, Beattie MS
• Plasticity in sacral spinal cord reflex circuits.
  Restorative neurology and neuroscience 1993 Beattie MS, Bresnahan JC, Leedy MG
• Anatomic and behavioral outcome after spinal cord injury produced by a displacement controlled impact device.
  Journal of neurotrauma 1992 Beattie MS
• Spinal cord injury produced by consistent mechanical displacement of the cord in rats: behavioral and histologic analysis.
  Journal of neurotrauma 1992 Behrmann DL, Bresnahan JC, Beattie MS, Shah BR
• Brachytherapy-induced blood-brain barrier injury.
  Journal of neurosurgery 1991 Stechison MT, Beattie MS
• Three-dimensional computer-assisted analysis of graded contusion lesions in the spinal cord of the rat.
  Journal of neurotrauma 1991 Bresnahan JC, Beattie MS, Stokes BT, Conway KM
• Metamorphosis alters the response to spinal cord transection in Xenopus laevis frogs.
  Journal of neurobiology 1990 Beattie MS, Bresnahan JC, Lopate G
• Motoneurons innervating the external anal and urethral sphincters of the female cat have different patterns of dendritic arborization.
  Neuroscience letters 1990 Beattie MS, Li Q, Leedy MG, Bresnahan JC
• Lymphocyte entry into inflammatory tissues in vivo. Qualitative differences of high endothelial venule-like vessels in sponge matrix allografts vs isografts.
  Journal of immunology (Baltimore, Md. : 1950) 1989 Bishop DK, Jutila MA, Sedmak DD, Beattie MS, Orosz CG
• Differences in synaptic inputs to preganglionic neurons in the dorsal and lateral band subdivisions of the cat sacral parasympathetic nucleus.
  The Journal of comparative neurology 1988 Leedy MG, Bresnahan JC, Mawe GM, Beattie MS
• Characterization of vasoactive intestinal peptide receptors in nervous and immune systems.
  Annals of the New York Academy of Sciences 1988 O'Dorisio MS, O'Dorisio TM, Wood CL, Bresnahan JC, Beattie MS, Campolito LB
• Testosterone-induced plasticity of synaptic inputs to adult mammalian motoneurons.
  Brain research 1987 Leedy MG, Beattie MS, Bresnahan JC
• Distribution and ultrastructure of ventral root afferents to lamina I of the cat sacral spinal cord.
  Neuroscience letters 1987 Beattie MS, Bresnahan JC, Mawe GM, Finn S
• A behavioral and anatomical analysis of spinal cord injury produced by a feedback-controlled impaction device.
  Experimental neurology 1987 Bresnahan JC, Beattie MS, Todd FD, Noyes DH
• Circumferential cells of the developing Rana catesbeiana lumbar spinal cord.
  Anatomy and embryology 1987 Campbell HL, Beattie MS, Bresnahan JC
• MR imaging of acute spinal cord trauma.
  AJNR. American journal of neuroradiology 1987 Chakeres DW, Flickinger F, Bresnahan JC, Beattie MS, Weiss KL, Miller C, Stokes BT
• A light and electron microscopic analysis of the sacral parasympathetic nucleus after labelling primary afferent and efferent elements with HRP.
  The Journal of comparative neurology 1986 Mawe GM, Bresnahan JC, Beattie MS
• Reducing conditions induce a total degradation of the major zymogen granule membrane protein in both its membranous and its soluble form. Immunochemical quantitation of the two forms.
  Biochemistry and cell biology = Biochimie et biologie cellulaire 1986 Paquette J, Leblond FA, Beattie M, LeBel D
• The development of the relationship between dorsal root afferents and motoneurons in the larval bullfrog spinal cord.
  Brain research bulletin 1985 Liuzzi FJ, Beattie MS, Bresnahan JC
• A comparison of the ultrastructure of substance P and enkephalin-immunoreactive elements in the nucleus of the dorsal lateral funiculus and laminae I and II of the rat spinal cord.
  The Journal of comparative neurology 1984 Bresnahan JC, Ho RH, Beattie MS
• The relationship of dorsal root afferents to motoneuron somata and dendrites in the adult bullfrog: a light and electron microscopic study using horseradish peroxidase.
  Neuroscience 1984 Liuzzi FJ, Beattie MS, Bresnahan JC
• Primary afferent projections from dorsal and ventral roots to autonomic preganglionic neurons in the cat sacral spinal cord: light and electron microscopic observations.
  Brain research 1984 Mawe GM, Bresnahan JC, Beattie MS
• Ultrastructure of HRP-labelled neurons: a comparison of two sensitive techniques.
  Brain research bulletin 1983 Mawe GM, Bresnahan JC, Beattie MS
• Dorsal root afferents contact migrating motoneurons in the developing frog spinal cord.
  Brain research 1983 Liuzzi FJ, Beattie MS, Bresnahan JC
• Ultrastructural identification of dorsal root primary afferent terminals after anterograde filling with horseradish peroxidase.
  Brain research 1978 Beattie MS, Bresnahan JC, King JS
• The organization of reticulo-olivo-cerebellar circuits in the North American opossum.
  Brain research 1977 Martin GF, Beattie MS, Hughes HC, Linauts M, Panneton M
• Some properties of substrates of memory.
  Advances in biochemical psychopharmacology 1977 Meyer DR, Beattie MS
• Effects of nicotinic and muscarinic compounds on biting attack in the cat.
  Pharmacology, biochemistry, and behavior 1976 Berntson GG, Beattie MS, Walker JM
• A comparison of hypothalamically induced biting attack with natural predatory behavior in the cat.
  Journal of comparative and physiological psychology 1976 Berntson GG, Hughes HC, Beattie MS
• Cortical and brain stem projections to the spinal cord of the American opossum, Didelphis marsupialis virginiana.
  Brain, behavior and evolution 1975 Martin GF, Beattie MS, Bresnahan JC, Henkel CK, Hughes HC