Michael Alexanian, PhD
Assistant Professor
Pediatrics
School of Medicine

Publications (24)

Top publication keywords:
EctodermChromatinHeart FailureChromatin Assembly and DisassemblyTranscription FactorsFibroblastsHeart DiseasesCell CommunicationGene Expression Regulation, DevelopmentalHeartMyofibroblastsHomeodomain ProteinsRNA, Long NoncodingLamin Type AEnhancer Elements, Genetic

• BRD4 inhibition rewires cardiac macrophages toward a protective phenotype marked by low MHC class II expression.
  American journal of physiology. Heart and circulatory physiology 2024 Schuetze KB, Stratton MS, Bagchi RA, Hobby ARH, Felisbino MB, Rubino M, Toni LS, Reges C, Cavasin MA, McMahan RH, Alexanian M, Vagnozzi RJ, McKinsey TA
• Chromatin remodelling drives immune cell-fibroblast communication in heart failure.
  Nature 2024 Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Pelonero A, Lee CY, Sadagopan N, Huang Y, Auclair K, Zhu A, An Y, Ekstrand CA, Martinez C, Teran BG, Flanigan WR, Kim CK, Lumbao-Conradson K, …
• A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation.
  Nature cardiovascular research 2024 Padmanabhan A, de Soysa TY, Pelonero A, Sapp V, Shah PP, Wang Q, Li L, Lee CY, Sadagopan N, Nishino T, Ye L, Yang R, Karnay A, Poleshko A, Bolar N, Linares-Saldana R, Ranade SS, Alexanian M, Morton SU…
• Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes.
  Nature cardiovascular research 2023 Nishino T, Ranade SS, Pelonero A, van Soldt BJ, Ye L, Alexanian M, Koback F, Huang Y, Sadagopan N, Lam A, Zholudeva LV, Li F, Padmanabhan A, Thomas R, van Bemmel JG, Gifford CA, Costa MW, Srivastava D
• Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis.
  bioRxiv : the preprint server for biology 2023 Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Lee CY, Sadagopan N, Huang Y, Pelonero A, Auclair K, Zhu A, Teran BG, Flanigan W, Kim CK, Lumbao-Conradson K, Costa M, Jain R, Charo I, Haldar …

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• Transcriptional plasticity of fibroblasts in heart disease.
  Biochemical Society transactions 2022 Micheletti R, Alexanian M
• Targeting transcription in heart failure via CDK7/12/13 inhibition.
  Nature communications 2022 Hsu A, Duan Q, Day DS, Luo X, McMahon S, Huang Y, Feldman ZB, Jiang Z, Zhang T, Liang Y, Alexanian M, Padmanabhan A, Brown JD, Lin CY, Gray NS, Young RA, Bruneau BG, Haldar SM
• KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation.
  Science advances 2022 Jiang Z, Elsarrag SZ, Duan Q, LaGory EL, Wang Z, Alexanian M, McMahon S, Rulifson IC, Winchester S, Wang Y, Vaisse C, Brown JD, Quattrocelli M, Lin CY, Haldar SM
• Transcription factor protein interactomes reveal genetic determinants in heart disease.
  Cell 2022 Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, …
• Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids.
  Cell stem cell 2021 Silva AC, Matthys OB, Joy DA, Kauss MA, Natarajan V, Lai MH, Turaga D, Blair AP, Alexanian M, Bruneau BG, McDevitt TC
• A transcriptional switch governs fibroblast activation in heart disease.
  Nature 2021 Alexanian M, Przytycki PF, Micheletti R, Padmanabhan A, Ye L, Travers JG, Gonzalez-Teran B, Silva AC, Duan Q, Ranade SS, Felix F, Linares-Saldana R, Li L, Lee CY, Sadagopan N, Pelonero A, Huang Y, …
• Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity.
  Cell systems 2020 Shim WJ, Sinniah E, Xu J, Vitrinel B, Alexanian M, Andreoletti G, Shen S, Sun Y, Balderson B, Boix C, Peng G, Jing N, Wang Y, Kellis M, Tam PPL, Smith A, Piper M, Christiaen L, Nguyen Q, Bodén M, …
• Long Noncoding RNAs in Cardiac Development.
  Cold Spring Harbor perspectives in biology 2020 Alexanian M, Ounzain S
• BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes.
  Circulation 2020 Padmanabhan A, Alexanian M, Linares-Saldana R, González-Terán B, Andreoletti G, Huang Y, Connolly AJ, Kim W, Hsu A, Duan Q, Winchester SAB, Felix F, Perez-Bermejo JA, Wang Q, Li L, Shah PP, Haldar SM,…
• BETs that cover the spread from acquired to heritable heart failure.
  The Journal of clinical investigation 2020 Alexanian M, Haldar SM
• Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.
  Circulation research 2019 Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MPY, Haldar SM, Lin CY, McKinsey TA
• Epigenetic therapies in heart failure.
  Journal of molecular and cellular cardiology 2019 Alexanian M, Padmanabhan A, McKinsey TA, Haldar SM
• The Cardiac Myofibroblast.
  Circulation research 2018 Alexanian M, Haldar SM
• A transcribed enhancer dictates mesendoderm specification in pluripotency.
  Nature communications 2017 Alexanian M, Maric D, Jenkinson SP, Mina M, Friedman CE, Ting CC, Micheletti R, Plaisance I, Nemir M, Maison D, Kernen J, Pezzuto I, Villeneuve D, Burdet F, Ibberson M, Leib SL, Palpant NJ, Hernandez …
• The long noncoding RNA Wisper controls cardiac fibrosis and remodeling.
  Science translational medicine 2017 Micheletti R, Plaisance I, Abraham BJ, Sarre A, Ting CC, Alexanian M, Maric D, Maison D, Nemir M, Young RA, Schroen B, González A, Ounzain S, Pedrazzini T
• New Lncs to mesendoderm specification.
  Journal of thoracic disease 2017 Alexanian M, Pedrazzini T, Ounzain S
• CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis.
  Journal of molecular and cellular cardiology 2015 Ounzain S, Micheletti R, Arnan C, Plaisance I, Cecchi D, Schroen B, Reverter F, Alexanian M, Gonzales C, Ng SY, Bussotti G, Pezzuto I, Notredame C, Heymans S, Guigó R, Johnson R, Pedrazzini T
• Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease.
  Journal of molecular and cellular cardiology 2014 Ounzain S, Pezzuto I, Micheletti R, Burdet F, Sheta R, Nemir M, Gonzales C, Sarre A, Alexanian M, Blow MJ, May D, Johnson R, Dauvillier J, Pennacchio LA, Pedrazzini T
• Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs.
  European heart journal 2014 Ounzain S, Micheletti R, Beckmann T, Schroen B, Alexanian M, Pezzuto I, Crippa S, Nemir M, Sarre A, Johnson R, Dauvillier J, Burdet F, Ibberson M, Guigó R, Xenarios I, Heymans S, Pedrazzini T