Mervyn Maze
Professor
Anesthesia
School of Medicine

Grants and Projects

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• Inflammation resolving mechanism dysregulation in postoperative cognitive decline, NIH, 2013-2018

Publications (173)

Top publication keywords:
HMGB1 ProteinNitrous OxideNeuroprotective AgentsEncephalitisXenonDeliriumAnesthetics, InhalationAdrenergic alpha-AgonistsAdrenergic alpha-2 Receptor AgonistsAnesthesiaPostoperative ComplicationsCognition DisordersHypnotics and SedativesDexmedetomidineNeurocognitive Disorders

• The role of cultural competency training to address health disparities in surgical settings.
  British medical bulletin 2024 Mora R, Maze M
• Clinical Use of Adrenergic Receptor Ligands in Acute Care Settings.
  Handbook of experimental pharmacology 2024 Langnas E, Maze M
• Resolution of elevated interleukin-6 after surgery is associated with return of normal cognitive function.
  British journal of anaesthesia 2023 Taylor J, Wu JG, Kunkel D, Parker M, Rivera C, Casey C, Naismith S, Teixeira-Pinto A, Maze M, Pearce RA, Lennertz R, Sanders RD
• High Mobility Group Box 1 (HMGB1): Potential Target in Sepsis-Associated Encephalopathy.
  Cells 2023 DeWulf B, Minsart L, Verdonk F, Kruys V, Piagnerelli M, Maze M, Saxena S
• Paradoxical increases in anterior cingulate cortex activity during nitrous oxide-induced analgesia reveal a signature of pain affect.
  bioRxiv : the preprint server for biology 2023 Weinrich JA, Liu CD, Jewell ME, Andolina CR, Bernstein MX, Benitez J, Rodriguez-Rosado S, Braz JM, Maze M, Nemenov MI, Basbaum AI

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• Involvement of KCa3.1 channel activity in immediate perioperative cognitive and neuroinflammatory outcomes.
  BMC anesthesiology 2023 Saxena S, Nuyens V, Rodts C, Jamar K, Albert A, Seidel L, Cherkaoui-Malki M, Boogaerts JG, Wulff H, Maze M, Kruys V, Vamecq J
• Defining the role of Interleukin-6 for the development of perioperative neurocognitive disorders: Evidence from clinical and preclinical studies.
  Frontiers in aging neuroscience 2023 Barreto Chang OL, Maze M
• Contribution of intraoperative electroencephalogram suppression to frailty-associated postoperative delirium: mediation analysis of a prospective surgical cohort.
  British journal of anaesthesia 2022 Fang PP, Shang ZX, Xu J, Hu J, Zhang SC, Fan YG, Lu Y, Liu XS, Maze M
• Longitudinal Profiling of Plasma Cytokines and Its Association With Postoperative Delirium in Elderly Patients Undergoing Major Lower Limb Surgery: A Prospective Observational Study.
  Anesthesia and analgesia 2022 Zhang Y, Hu J, Zuo W, He P, Xue Q, Feng X, Zhang Y, Maze M
• Comparison of the prognostic value of early-phase proton magnetic resonance spectroscopy and diffusion tensor imaging with serum neuron-specific enolase at 72 h in comatose survivors of out-of-hospital cardiac arrest-a substudy of the XeHypotheca trial.
  Neuroradiology 2022 Koskensalo K, Virtanen S, Saunavaara J, Parkkola R, Laitio R, Arola O, Hynninen M, Silvasti P, Nukarinen E, Martola J, Silvennoinen HM, Tiainen M, Roine RO, Scheinin H, Saraste A, Maze M, Vahlberg T, …
• Interleukin-6 trans-signalling in hippocampal CA1 neurones mediates perioperative neurocognitive disorders in mice.
  British journal of anaesthesia 2022 Hu J, Zhang Y, Huang C, Feng X, He S, Zhang Y, Maze M
• Plasma fibrinogen: An important piece of the COVID-19 ICU delirium puzzle?
  Medical hypotheses 2022 Saxena S, Wery AR, Khelif A, Nisolle ML, Lelubre C, Maze M, Biston P, Piagnerelli M
• Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets.
  Annual review of pharmacology and toxicology 2022 Barreto Chang OL, Possin KL, Maze M
• Considerations for the implementation of machine learning into acute care settings.
  British medical bulletin 2022 Bishara A, Maze EH, Maze M
• Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia.
  European journal of anaesthesiology 2022 Hu J, Zhang Y, Maze M
• Early postoperative risk prediction of neurocognitive decline.
  British journal of anaesthesia 2022 Saxena S, Rodts C, Nuyens V, Seidel L, Albert A, Boogaerts J, Kruys V, Maze M, Vamecq J
• Design of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III.
  Critical care medicine 2021 Ward DS, Absalom AR, Aitken LM, Balas MC, Brown DL, Burry L, Colantuoni E, Coursin D, Devlin JW, Dexter F, Dworkin RH, Egan TD, Elliott D, Egerod I, Flood P, Fraser GL, Girard TD, Gozal D, Hopkins RO,…
• Effect of Intraoperative Dexmedetomidine on Recovery of Gastrointestinal Function After Abdominal Surgery in Older Adults: A Randomized Clinical Trial.
  JAMA network open 2021 Lu Y, Fang PP, Yu YQ, Cheng XQ, Feng XM, Wong GTC, Maze M, Liu XS, POGF Study Collaborators
• High-Mobility Group Box-1 and Its Potential Role in Perioperative Neurocognitive Disorders.
  Cells 2021 Saxena S, Kruys V, De Jongh R, Vamecq J, Maze M
• Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest-A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial.
  Critical care explorations 2021 Saraste A, Ballo H, Arola O, Laitio R, Airaksinen J, Hynninen M, Bäcklund M, Ylikoski E, Wennervirta J, Pietilä M, Roine RO, Harjola VP, Niiranen J, Korpi K, Varpula M, Scheinin H, Maze M, Vahlberg T,…
• The Role of Microglia in Perioperative Neuroinflammation and Neurocognitive Disorders.
  Frontiers in aging neuroscience 2021 Saxena S, Kruys V, Vamecq J, Maze M
• Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia: A double-blind, randomised clinical trial.
  European journal of anaesthesiology 2021 Hu J, Zhu M, Gao Z, Zhao S, Feng X, Chen J, Zhang Y, Maze M
• Preoperative sedentary behavior is neither a risk factor for perioperative neurocognitive disorders nor associated with an increase in peripheral inflammation, a prospective observational cohort study.
  BMC anesthesiology 2020 Saxena S, Rodts C, Nuyens V, Lazaron J, Sosnowski V, Verdonk F, Seidel L, Albert A, Boogaerts J, Kruys V, Maze M, Vamecq J
• Robert D. Sanders, B.Sc., M.B.B.S., Ph.D., F.R.C.A., Recipient of the 2020 James E. Cottrell, M.D., Presidential Scholar Award.
  Anesthesiology 2020 Pearce RA, Maze M
• Dexmedetomidine Exerts an Anti-inflammatory Effect via α2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice.
  Anesthesiology 2020 Li R, Lai IK, Pan JZ, Zhang P, Maze M
• Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice.
  British journal of anaesthesia 2020 Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M
• Perioperative Neurocognitive Disorder: State of the Preclinical Science.
  Anesthesiology 2020 Eckenhoff RG, Maze M, Xie Z, Culley DJ, Goodlin SJ, Zuo Z, Wei H, Whittington RA, Terrando N, Orser BA, Eckenhoff MF
• Neuroprotective Properties of Xenon.
  Molecular neurobiology 2019 Maze M, Laitio T
• Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury.
  British journal of anaesthesia 2019 Gao J, Sun Z, Xiao Z, Du Q, Niu X, Wang G, Chang YW, Sun Y, Sun W, Lin A, Bresnahan JC, Maze M, Beattie MS, Pan JZ
• Impact of Dexmedetomidine on Long-term Outcomes After Noncardiac Surgery in Elderly: 3-Year Follow-up of a Randomized Controlled Trial.
  Annals of surgery 2019 Zhang DF, Su X, Meng ZT, Li HL, Wang DX, Maze M, Ma D
• Protecting the Brain With Xenon Anesthesia for Neurosurgical Procedures.
  Journal of neurosurgical anesthesiology 2019 Rylova A, Maze M
• Specialised pro-resolving mediators: the magic bullet for perioperative neurocognitive disorders?
  British journal of anaesthesia 2018 Li R, Lai IK, Maze M
• Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group.
  Anesthesia and analgesia 2018 Berger M, Schenning KJ, Brown CH, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, …
• Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein-induced Inflammation through a Vagomimetic Action in Mice.
  Anesthesiology 2018 Hu J, Vacas S, Feng X, Lutrin D, Uchida Y, Lai IK, Maze M
• Restoring Order to Postoperative Neurocognitive Disorders.
  JAMA neurology 2018 Saxena S, Uchida Y, Maze M
• Impact on the brain of the inflammatory response to surgery.
  Presse medicale (Paris, France : 1983) 2018 Saxena S, Maze M
• Past, present, and future of nitrous oxide.
  British medical bulletin 2018 Lew V, McKay E, Maze M
• Methods for Defining the Neuroprotective Properties of Xenon.
  Methods in enzymology 2018 Robel R, Caroccio P, Maze M
• Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice.
  British journal of anaesthesia 2018 Hu J, Feng X, Valdearcos M, Lutrin D, Uchida Y, Koliwad SK, Maze M
• Exercise Prevents Enhanced Postoperative Neuroinflammation and Cognitive Decline and Rectifies the Gut Microbiome in a Rat Model of Metabolic Syndrome.
  Frontiers in immunology 2017 Feng X, Uchida Y, Koch L, Britton S, Hu J, Lutrin D, Maze M
• Perioperative management of the obese surgical patient.
  British medical bulletin 2017 Lang LH, Parekh K, Tsui BYK, Maze M
• Inhaled Xenon Attenuates Myocardial Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The Xe-Hypotheca Trial.
  Journal of the American College of Cardiology 2017 Arola O, Saraste A, Laitio R, Airaksinen J, Hynninen M, Bäcklund M, Ylikoski E, Wennervirta J, Pietilä M, Roine RO, Harjola VP, Niiranen J, Korpi K, Varpula M, Scheinin H, Maze M, Vahlberg T, Laitio T…
• In Response.
  Anesthesia and analgesia 2017 Vacas S, Maze M
• The immune response of the human brain to abdominal surgery.
  Annals of neurology 2017 Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen LS, Zetterberg H, Erlandsson Harris H, Stridh P, Christensson E, Granström A, Schening A, Dymmel K, Knave N, Terrando N, Maze M, Borg J, Varrone …
• Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice.
  JCI insight 2017 Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad SK
• Neuroprotection and neurotoxicity in the developing brain: an update on the effects of dexmedetomidine and xenon.
  Neurotoxicology and teratology 2017 Alam A, Suen KC, Hana Z, Sanders RD, Maze M, Ma D
• Fragmented Sleep Enhances Postoperative Neuroinflammation but Not Cognitive Dysfunction.
  Anesthesia and analgesia 2017 Vacas S, Degos V, Maze M
• Initiating Mechanisms of Surgery-induced Memory Decline: The Role of HMGB1.
  Journal of clinical & cellular immunology 2016 Vacas S, Maze M
• "A Time of Opportunity": Patient Safety and the Perioperative Surgical Home.
  Anesthesia and analgesia 2016 Garson LM, Vakharia S, Edwards AF, Maze M
• From Bench to Bedside and Back Again: A Personal Journey with Dexmedetomidine.
  Anesthesiology 2016 Maze M
• Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery.
  Journal of neuroinflammation 2016 Hirsch J, Vacas S, Terrando N, Yuan M, Sands LP, Kramer J, Bozic K, Maze MM, Leung JM
• Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial.
  Lancet (London, England) 2016 Su X, Meng ZT, Wu XH, Cui F, Li HL, Wang DX, Zhu X, Zhu SN, Maze M, Ma D
• The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor.
  Anesthesia and analgesia 2016 Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung JM
• Therapeutic drug monitoring of isoniazid and rifampicin during anti-tuberculosis treatment in Auckland, New Zealand.
  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2016 Maze MJ, Paynter J, Chiu W, Hu R, Nisbet M, Lewis C
• Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial.
  JAMA 2016 Laitio R, Hynninen M, Arola O, Virtanen S, Parkkola R, Saunavaara J, Roine RO, Grönlund J, Ylikoski E, Wennervirta J, Bäcklund M, Silvasti P, Nukarinen E, Tiainen M, Saraste A, Pietilä M, Airaksinen J…
• Will Xenon Be a Valuable Addition in Perioperative and Critical Care Settings?
  Anesthesia and analgesia 2016 Maze M, Pirracchio R
• Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial.
  The Lancet. Neurology 2015 Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deierl A, Fagiolo G, Franks NP, Griffiths J, Hajnal J, Juszczak E, Kapetanakis B, Linsell L, Maze M, Omar O, Strohm B, Tusor N, …
• Preclinical neuroprotective actions of xenon and possible implications for human therapeutics: a narrative review.
  Canadian journal of anaesthesia = Journal canadien d'anesthesie 2015 Maze M
• Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome.
  Brain, behavior, and immunity 2015 Gambús PL, Trocóniz IF, Feng X, Gimenez-Milá M, Mellado R, Degos V, Vacas S, Maze M
• Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome.
  PloS one 2015 Feng X, Maze M, Koch LG, Britton SL, Hellman J
• Preoperative medical testing in Medicare patients undergoing cataract surgery.
  The New England journal of medicine 2015 Chen CL, Lin GA, Bardach NS, Clay TH, Boscardin WJ, Gelb AW, Maze M, Gropper MA, Dudley RA
• Immune cell expression of GABAA receptors and the effects of diazepam on influenza infection.
  Journal of neuroimmunology 2015 Sanders RD, Grover V, Goulding J, Godlee A, Gurney S, Snelgrove R, Ma D, Singh S, Maze M, Hussell T
• Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.
  Molecular medicine (Cambridge, Mass.) 2015 Terrando N, Yang T, Ryu JK, Newton PT, Monaco C, Feldmann M, Ma D, Akassoglou K, Maze M
• In reply.
  Anesthesiology 2014 Vacas S, Degos V, Maze M
• Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.
  PloS one 2014 Han Z, Shen F, He Y, Degos V, Camus M, Maze M, Young WL, Su H
• Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture.
  Journal of neurochemistry 2014 Han Z, Li L, Wang L, Degos V, Maze M, Su H
• Endoglin deficiency impairs stroke recovery.
  Stroke 2014 Shen F, Degos V, Chu PL, Han Z, Westbroek EM, Choi EJ, Marchuk D, Kim H, Lawton MT, Maze M, Young WL, Su H
• High-mobility group box 1 protein initiates postoperative cognitive decline by engaging bone marrow-derived macrophages.
  Anesthesiology 2014 Vacas S, Degos V, Tracey KJ, Maze M
• Bundled payments in total joint arthroplasty: targeting opportunities for quality improvement and cost reduction.
  Clinical orthopaedics and related research 2014 Bozic KJ, Ward L, Vail TP, Maze M
• Take off, landing, and fly anesthesia.
  PLoS genetics 2013 Sanders RD, Maze M
• Feasibility and cardiac safety of inhaled xenon in combination with therapeutic hypothermia following out-of-hospital cardiac arrest.
  Critical care medicine 2013 Arola OJ, Laitio RM, Roine RO, Grönlund J, Saraste A, Pietilä M, Airaksinen J, Perttilä J, Scheinin H, Olkkola KT, Maze M, Laitio TT
• Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice.
  Critical care medicine 2013 Sanders RD, Godlee A, Fujimori T, Goulding J, Xin G, Salek-Ardakani S, Snelgrove RJ, Ma D, Maze M, Hussell T
• Bone fracture exacerbates murine ischemic cerebral injury.
  Anesthesiology 2013 Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen F, Jun K, van Rooijen N, Gressens P, Young WL, Su H
• Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome.
  Anesthesiology 2013 Feng X, Degos V, Koch LG, Britton SL, Zhu Y, Vacas S, Terrando N, Nelson J, Su X, Maze M
• The neuroinflammatory response of postoperative cognitive decline.
  British medical bulletin 2013 Vacas S, Degos V, Feng X, Maze M
• G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration.
  Annals of neurology 2013 Degos V, Peineau S, Nijboer C, Kaindl AM, Sigaut S, Favrais G, Plaisant F, Teissier N, Gouadon E, Lombet A, Saliba E, Collingridge GL, Maze M, Nicoletti F, Heijnen C, Mantz J, Kavelaars A, Gressens P
• Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction.
  Anesthesiology 2013 Degos V, Vacas S, Han Z, van Rooijen N, Gressens P, Su H, Young WL, Maze M
• Sleep and Anesthesia - Common mechanisms of action.
  Sleep medicine clinics 2013 Vacas S, Kurien P, Maze M
• Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome.
  Molecular medicine (Cambridge, Mass.) 2013 Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M
• Parenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice.
  Influenza and other respiratory viruses 2012 Sanders RD, Godlee A, Goulding JC, Ma D, Maze M, Hussell T
• Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.
  Anesthesiology 2012 Sheng SP, Lei B, James ML, Lascola CD, Venkatraman TN, Jung JY, Maze M, Franks NP, Pearlstein RD, Sheng H, Warner DS
• Noradrenergic trespass in anesthetic and sedative states.
  Anesthesiology 2012 Sanders RD, Maze M
• The Hip Fracture Surgery in Elderly Patients (HIPELD) study: protocol for a randomized, multicenter controlled trial evaluating the effect of xenon on postoperative delirium in older patients undergoing hip fracture surgery.
  Trials 2012 Coburn M, Sanders RD, Maze M, Rossaint R, HIPELD Investigators
• Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia.
  PloS one 2012 Yang T, Zhuang L, Rei Fidalgo AM, Petrides E, Terrando N, Wu X, Sanders RD, Robertson NJ, Johnson MR, Maze M, Ma D
• Independent preoperative predictors of outcomes in orthopedic and vascular surgery: the influence of time interval between an acute coronary syndrome or stroke and the operation.
  Annals of surgery 2012 Sanders RD, Bottle A, Jameson SS, Mozid A, Aylin P, Edger L, Ma D, Reed MR, Walters M, Lees KR, Maze M
• Reprogramming of the infant brain by surgery with general anesthesia.
  Mayo Clinic proceedings 2012 Culley DJ, Maze M, Crosby G
• Resolving postoperative neuroinflammation and cognitive decline.
  Annals of neurology 2011 Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M
• N-(Imidazolidin-2-ylidene)-1-arylmethanamine oxides: synthesis, structure and pharmacological evaluation.
  Archiv der Pharmazie 2011 Saczewski J, Hudson A, Laird S, Rybczynska A, Boblewski K, Lehmann A, Ma D, Maze M, Watts H, Gdaniec M
• Xenon pretreatment may prevent early memory decline after isoflurane anesthesia and surgery in mice.
  PloS one 2011 Vizcaychipi MP, Lloyd DG, Wan Y, Palazzo MG, Maze M, Ma D
• Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain.
  Neurobiology of disease 2011 Shu Y, Zhou Z, Wan Y, Sanders RD, Li M, Pac-Soo CK, Maze M, Ma D
• Perioperative cognitive decline in the aging population.
  Mayo Clinic proceedings 2011 Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung JM, Miller BL, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M
• Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop.
  The Journal of pediatrics 2011 Higgins RD, Raju T, Edwards AD, Azzopardi DV, Bose CL, Clark RH, Ferriero DM, Guillet R, Gunn AJ, Hagberg H, Hirtz D, Inder TE, Jacobs SE, Jenkins D, Juul S, Laptook AR, Lucey JF, Maze M, Palmer C, …
• Anticipating and managing postoperative delirium and cognitive decline in adults.
  BMJ (Clinical research ed.) 2011 Sanders RD, Pandharipande PP, Davidson AJ, Ma D, Maze M
• Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice.
  Critical care (London, England) 2011 Gu J, Sun P, Zhao H, Watts HR, Sanders RD, Terrando N, Xia P, Maze M, Ma D
• Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxia.
  Annals of neurology 2011 Faulkner S, Bainbridge A, Kato T, Chandrasekaran M, Kapetanakis AB, Hristova M, Liu M, Evans S, De Vita E, Kelen D, Sanders RD, Edwards AD, Maze M, Cady EB, Raivich G, Robertson NJ
• Systemic inflammation enhances surgery-induced cognitive dysfunction in mice.
  Neuroscience letters 2011 Fidalgo AR, Cibelli M, White JP, Nagy I, Maze M, Ma D
• Heat shock protein 72 overexpression prevents early postoperative memory decline after orthopedic surgery under general anesthesia in mice.
  Anesthesiology 2011 Vizcaychipi MP, Xu L, Barreto GE, Ma D, Maze M, Giffard RG
• A clinically relevant model of perinatal global ischemic brain damage in rats.
  Brain research 2011 Yang T, Zhuang L, Terrando N, Wu X, Jonhson MR, Maze M, Ma D
• Contribution of sedative-hypnotic agents to delirium via modulation of the sleep pathway.
  Canadian journal of anaesthesia = Journal canadien d'anesthesie 2010 Sanders RD, Maze M
• Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice.
  Critical care medicine 2010 Wan Y, Xu J, Meng F, Bao Y, Ge Y, Lobo N, Vizcaychipi MP, Zhang D, Gentleman SM, Maze M, Ma D
• Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Terrando N, Monaco C, Ma D, Foxwell BM, Feldmann M, Maze M
• Role of interleukin-1beta in postoperative cognitive dysfunction.
  Annals of neurology 2010 Cibelli M, Fidalgo AR, Terrando N, Ma D, Monaco C, Feldmann M, Takata M, Lever IJ, Nanchahal J, Fanselow MS, Maze M
• Xenon pretreatment attenuates anesthetic-induced apoptosis in the developing brain in comparison with nitrous oxide and hypoxia.
  Anesthesiology 2010 Shu Y, Patel SM, Pac-Soo C, Fidalgo AR, Wan Y, Maze M, Ma D
• Preconditioning and postinsult therapies for perinatal hypoxic-ischemic injury at term.
  Anesthesiology 2010 Sanders RD, Manning HJ, Robertson NJ, Ma D, Edwards AD, Hagberg H, Maze M
• Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells.
  Experimental biology and medicine (Maywood, N.J.) 2010 Rizvi M, Jawad N, Li Y, Vizcaychipi MP, Maze M, Ma D
• The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction.
  Critical care (London, England) 2010 Terrando N, Rei Fidalgo A, Vizcaychipi M, Cibelli M, Ma D, Monaco C, Feldmann M, Maze M
• Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial.
  Critical care (London, England) 2010 Pandharipande PP, Sanders RD, Girard TD, McGrane S, Thompson JL, Shintani AK, Herr DL, Maze M, Ely EW, MENDS investigators
• Noble gas xenon is a novel adenosine triphosphate-sensitive potassium channel opener.
  Anesthesiology 2010 Bantel C, Maze M, Trapp S
• Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain.
  Anesthesiology 2010 White JP, Cibelli M, Rei Fidalgo A, Paule CC, Noormohamed F, Urban L, Maze M, Nagy I
• Argon neuroprotection.
  Critical care (London, England) 2010 Sanders RD, Ma D, Maze M
• Neuroinflammation and postoperative cognitive dysfunction: can anaesthesia be therapeutic?
  European journal of anaesthesiology 2010 Sanders RD, Maze M
• Does correcting the numbers improve long-term outcome?
  Anesthesiology 2009 Sanders RD, Maze M
• Sedation improves early outcome in severely septic Sprague Dawley rats.
  Critical care (London, England) 2009 Qiao H, Sanders RD, Ma D, Wu X, Maze M
• Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury.
  Neuroscience letters 2009 Jawad N, Rizvi M, Gu J, Adeyi O, Tao G, Maze M, Ma D
• Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats.
  Anesthesiology 2009 Sanders RD, Xu J, Shu Y, Januszewski A, Halder S, Fidalgo A, Sun P, Hossain M, Ma D, Maze M
• Neuronal preconditioning by inhalational anesthetics: evidence for the role of plasmalemmal adenosine triphosphate-sensitive potassium channels.
  Anesthesiology 2009 Bantel C, Maze M, Trapp S
• Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation.
  Journal of the American Society of Nephrology : JASN 2009 Ma D, Lim T, Xu J, Tang H, Wan Y, Zhao H, Hossain M, Maxwell PH, Maze M
• Xenon and sevoflurane protect against brain injury in a neonatal asphyxia model.
  Anesthesiology 2008 Luo Y, Ma D, Ieong E, Sanders RD, Yu B, Hossain M, Maze M
• Biologic effects of nitrous oxide: a mechanistic and toxicologic review.
  Anesthesiology 2008 Sanders RD, Weimann J, Maze M
• Xenon up-regulates several genes that are not up-regulated by nitrous oxide.
  Journal of neurosurgical anesthesiology 2008 Valleggi S, Cavazzana AO, Bernardi R, Ma D, Natale G, Maze M, Cattano D, Davide C, Giunta F
• Expecting the unexpected.
  Anesthesia and analgesia 2008 Talke PO, Maze M
• General anesthetics induce apoptotic neurodegeneration in the neonatal rat spinal cord.
  Anesthesia and analgesia 2008 Sanders RD, Xu J, Shu Y, Fidalgo A, Ma D, Maze M
• Role of endogenous sleep-wake and analgesic systems in anesthesia.
  The Journal of comparative neurology 2008 Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB
• Xenon induces transcription of ADNP in neonatal rat brain.
  Neuroscience letters 2008 Cattano D, Valleggi S, Ma D, Kastsiuchenka O, Abramo A, Sun P, Cavazzana AO, Natale G, Maze M, Giunta F
• The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury.
  Critical care medicine 2008 Coburn M, Maze M, Franks NP
• Taking the lead in research into postoperative cognitive dysfunction.
  Anesthesiology 2008 Maze M, Cibelli M, Grocott HP
• Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial.
  JAMA 2007 Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA, Stiles RA, Dittus RS, Bernard GR, Ely EW
• Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology.
  Anesthesiology 2007 Dickinson R, Peterson BK, Banks P, Simillis C, Martin JC, Valenzuela CA, Maze M, Franks NP
• Translational research: addressing problems facing the anesthesiologist.
  Anesthesia and analgesia 2007 Sanders RD, Maze M
• Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain.
  Anesthesiology 2007 Ma D, Williamson P, Januszewski A, Nogaro MC, Hossain M, Ong LP, Shu Y, Franks NP, Maze M
• Postoperative cognitive dysfunction after noncardiac surgery: a systematic review.
  Anesthesiology 2007 Newman S, Stygall J, Hirani S, Shaefi S, Maze M
• Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
  Anesthesiology 2007 Wan Y, Xu J, Ma D, Zeng Y, Cibelli M, Maze M
• Special issue on postoperative cognitive dysfunction: selected reports from the journal-sponsored symposium.
  Anesthesiology 2007 Maze M, Todd MM
• Alpha2-adrenoceptor agonists.
  Current opinion in investigational drugs (London, England : 2000) 2007 Sanders RD, Maze M
• The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study.
  Anesthesia and analgesia 2006 Sakamoto S, Nakao S, Masuzawa M, Inada T, Maze M, Franks NP, Shingu K
• Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models.
  Neuroscience letters 2006 Rajakumaraswamy N, Ma D, Hossain M, Sanders RD, Franks NP, Maze M
• Molecular mechanisms transducing the anesthetic, analgesic, and organ-protective actions of xenon.
  Anesthesiology 2006 Preckel B, Weber NC, Sanders RD, Maze M, Schlack W
• The role of the craniospinal nerves in mediating the antinociceptive effect of transcranial electrostimulation in the rat.
  Anesthesia and analgesia 2006 Nekhendzy V, Davies MF, Lemmens HJ, Maze M
• A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management.
  Anesthesiology 2006 Holdcroft A, Maze M, Doré C, Tebbs S, Thompson S
• Feasibility and safety of delivering xenon to patients undergoing coronary artery bypass graft surgery while on cardiopulmonary bypass: phase I study.
  Anesthesiology 2006 Lockwood GG, Franks NP, Downie NA, Taylor KM, Maze M
• Expansion of gas bubbles by nitrous oxide and xenon.
  Anesthesiology 2006 Benavides R, Maze M, Franks NP
• Xenon preconditioning reduces brain damage from neonatal asphyxia in rats.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006 Ma D, Hossain M, Pettet GK, Luo Y, Lim T, Akimov S, Sanders RD, Franks NP, Maze M
• Anaesthesia induced neuroprotection.
  Best practice & research. Clinical anaesthesiology 2005 Sanders RD, Ma D, Maze M
• Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia.
  Annals of neurology 2005 Ma D, Hossain M, Chow A, Arshad M, Battson RM, Sanders RD, Mehmet H, Edwards AD, Franks NP, Maze M
• Xenon and the inflammatory response to cardiopulmonary bypass in the rat.
  Journal of cardiothoracic and vascular anesthesia 2005 Clark JA, Ma D, Homi HM, Maze M, Grocott HP
• Xenon: from stranger to guardian.
  Current opinion in anaesthesiology 2005 Sanders RD, Maze M
• Dexmedetomidine exerts dose-dependent age-independent antinociception but age-dependent hypnosis in Fischer rats.
  Anesthesia and analgesia 2005 Sanders RD, Giombini M, Ma D, Ohashi Y, Hossain M, Fujinaga M, Maze M
• Xenon: elemental anaesthesia in clinical practice.
  British medical bulletin 2005 Sanders RD, Ma D, Maze M
• alpha2-Adrenoceptor agonists: shedding light on neuroprotection?
  British medical bulletin 2005 Ma D, Rajakumaraswamy N, Maze M
• Dexmedetomidine and opioid interactions: defining the role of dexmedetomidine for intensive care unit sedation.
  Anesthesiology 2004 Maze M, Angst MS
• Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype.
  European journal of pharmacology 2004 Ma D, Hossain M, Rajakumaraswamy N, Arshad M, Sanders RD, Franks NP, Maze M
• Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans.
  Anesthesiology 2004 Angst MS, Ramaswamy B, Davies MF, Maze M
• Dexmedetomidine: another arrow for the clinician's quiver.
  Anesthesiology 2004 Ebert T, Maze M
• Rested and refreshed after anesthesia? Overlapping neurobiologic mechanisms of sleep and anesthesia.
  Anesthesiology 2004 Nelson LE, Franks NP, Maze M
• Attentional effects of noradrenaline vary with arousal level: selective activation of thalamic pulvinar in humans.
  NeuroImage 2004 Coull JT, Jones ME, Egan TD, Frith CD, Maze M
• Xenon exerts age-independent antinociception in Fischer rats.
  Anesthesiology 2004 Ma D, Sanders RD, Halder S, Rajakumaraswamy N, Franks NP, Maze M
• Dexmedetomidine enhances analgesic action of nitrous oxide: mechanisms of action.
  Anesthesiology 2004 Dawson C, Ma D, Chow A, Maze M
• The antinociceptive effect of transcranial electrostimulation with combined direct and alternating current in freely moving rats.
  Anesthesia and analgesia 2004 Nekhendzy V, Fender CP, Davies MF, Lemmens HJ, Kim MS, Bouley DM, Maze M
• Brain stem opioidergic and GABAergic neurons mediate the antinociceptive effect of nitrous oxide in Fischer rats.
  Anesthesiology 2003 Ohashi Y, Guo T, Orii R, Maze M, Fujinaga M
• The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice.
  Anesthesiology 2003 Homi HM, Yokoo N, Ma D, Warner DS, Franks NP, Maze M, Grocott HP
• Combination of xenon and isoflurane produces a synergistic protective effect against oxygen-glucose deprivation injury in a neuronal-glial co-culture model.
  Anesthesiology 2003 Ma D, Hossain M, Rajakumaraswamy N, Franks NP, Maze M
• Corticotropin-releasing factor mediates the antinociceptive action of nitrous oxide in rats.
  Anesthesiology 2003 Sawamura S, Obara M, Takeda K, Maze M, Hanaoka K
• GABAergic interneurons at supraspinal and spinal levels differentially modulate the antinociceptive effect of nitrous oxide in Fischer rats.
  Anesthesiology 2003 Orii R, Ohashi Y, Halder S, Giombini M, Maze M, Fujinaga M
• Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat.
  Anesthesiology 2003 Ma D, Yang H, Lynch J, Franks NP, Maze M, Grocott HP
• The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects.
  Anesthesiology 2003 Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M
• Effects of xenon on in vitro and in vivo models of neuronal injury.
  Anesthesiology 2002 Wilhelm S, Ma D, Maze M, Franks NP
• Meperidine exerts agonist activity at the alpha(2B)-adrenoceptor subtype.
  Anesthesiology 2002 Takada K, Clark DJ, Davies MF, Tonner PH, Krause TK, Bertaccini E, Maze M
• Neurobiology of nitrous oxide-induced antinociceptive effects.
  Molecular neurobiology 2002 Fujinaga M, Maze M
• Isoflurane and nociception: spinal alpha2A adrenoceptors mediate antinociception while supraspinal alpha1 adrenoceptors mediate pronociception.
  Anesthesiology 2002 Kingery WS, Agashe GS, Guo TZ, Sawamura S, Davies MF, Clark JD, Kobilka BK, Maze M
• Capsaicin sensitive afferents mediate the development of heat hyperalgesia and hindpaw edema after sciatic section in rats.
  Neuroscience letters 2002 Kingery WS, Agashe GS, Guo TZ, Davies MF, Clark JD, Maze M
• Developmental variation in nitrous oxide-induced c-fos expression in Fischer rat spinal cord.
  Anesthesiology 2002 Hashimoto T, Ohashi Y, Nelson LE, Maze M, Fujinaga M
• The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice.
  Pain 2000 Kingery WS, Guo TZ, Davies FM, Limbird L, Maze M
• Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.
  Pain 1999 Kingery WS, Castellote JM, Maze M