Merlin Larson, MD
Professor Emeritus
Anesthesia
School of Medicine

Education & Training

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• University of Kansas 1965

Websites

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• Clinical Profile at UCSF Medical Center (ucsfhealth.org)

Publications (41)

Top publication keywords:
GoalsAnesthesia, GeneralPain MeasurementReflex, PupillaryAnesthesiologyPupilIntraoperative PeriodFentanylAnalgesics, OpioidWeights and MeasuresAnesthesia, EpiduralPain, PostoperativeNociceptionInfrared RaysRespiratory Insufficiency

• Measurements of pupillary unrest using infrared pupillometry fail to detect changes in pain intensity in patients after surgery: a prospective observational study.
  Canadian journal of anaesthesia = Journal canadien d'anesthesie 2024 Behrends M, Larson MD
• Overcoming Obstacles: The Legacy of Fidel Pagés, Founder of the Epidural, 100 Years After His Passing.
  Anesthesia and analgesia 2023 Chinn GA, Gray AT, Larson MD
• Commentary on pupillometry and pain ratings.
  European journal of pain (London, England) 2023 Larson MD
• Brimonidine eye drops reveal diminished sympathetic pupillary tone in comatose patients with brain injury.
  Acta neurochirurgica 2023 Jakobsen EW, Nersesjan V, Albrechtsen SS, Othman MH, Amiri M, Knudsen NV, Larson MD, Hassager C, Møller K, Kjaergaard J, Kondziella D
• Reader Response: Automated Quantitative Pupillometry in the Critically Ill: A Systematic Review of the Literature.
  Neurology 2021 Larson MD

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• Semimechanistic models to relate noxious stimulation, movement, and pupillary dilation responses in the presence of opioids.
  CPT: pharmacometrics & systems pharmacology 2021 Marco-Ariño N, Vide S, Agustí M, Chen A, Jaramillo S, Irurzun-Arana I, Pacheco A, Gonzalez C, Jensen EW, Capsi-Morales P, Valencia JF, Troconiz IF, Gambus PL, Larson MD
• Detection of Opioid Effect with Pupillometry
  Autonomic Neuroscience 2021 McKay, Rachel Eshima Larson, Merlin D.
• Monitoring the Depth of Palliative Sedation by Video-Pupillometry: A Case Report. Palliative Medicine
  Monitoring the Depth of Palliative Sedation by Video-Pupillometry: A Case Report. Palliative Medicine 2021 Elyn, A Saffon, N Larson, M
• Reader Response: Automated Quantitative Pupillometry in the Critically Ill. Neurology
  Reader Response: Automated Quantitative Pupillometry in the Critically Ill. Neurology 2021 Larson, M
• Pupillary unrest, opioid intensity, and the impact of environmental stimulation on respiratory depression.
  Journal of clinical monitoring and computing 2021 McKay RE, Kohn MA, Larson MD
• Evaluation of two portable pupillometers to assess clinical utility.
  Concussion (London, England) 2020 McKay RE, Kohn MA, Schwartz ES, Larson MD
• Nociceptive monitor subtypes. Comment on 'Objective monitoring of nociception: a review of current commercial solutions' (Br J Anaesth 2019; 123:e312-e321).
  British journal of anaesthesia 2019 Larson M, Neice A
• Pharmacodynamic modelling of the effect of remifentanil using the Pupillary Pain Index.
  Journal of clinical monitoring and computing 2019 Vide S, Castro A, Antunes P, Lima D, Larson M, Gambús P, Amorim P
• Suppression of pupillary unrest by general anesthesia and propofol sedation.
  Journal of clinical monitoring and computing 2018 Behrends M, Larson MD, Neice AE, Bokoch MP
• Pupillary Unrest in Ambient Light and Prediction of Opioid Responsiveness: Case Report on Its Utility in the Management of 2 Patients With Challenging Acute Pain Conditions.
  A&A practice 2018 McKay RE, Neice AE, Larson MD
• In Response.
  Anesthesia and analgesia 2017 Neice AE, Larson MD, Behrends M, Bokoch MP
• Prediction of Opioid Analgesic Efficacy by Measurement of Pupillary Unrest.
  Anesthesia and analgesia 2017 Neice AE, Behrends M, Bokoch MP, Seligman KM, Conrad NM, Larson MD
• Portable infrared pupillometry in critical care.
  Critical care (London, England) 2016 Larson MD, Singh V
• Portable infrared pupillometry: a review.
  Anesthesia and analgesia 2015 Larson MD, Behrends M
• Pupillary Reflex Dilation to Predict Movement: A Step Forward Toward Real-time Individualized Intravenous Anesthetics.
  Anesthesiology 2015 Larson MD, Gupta DK
• Fentanyl, an agonist at the mu opioid receptor, depresses pupillary unrest.
  Autonomic neuroscience : basic & clinical 2015 Bokoch MP, Behrends M, Neice A, Larson MD
• Pupillary effects of high-dose opioid quantified with infrared pupillometry.
  Anesthesiology 2014 Rollins MD, Feiner JR, Lee JM, Shah S, Larson M
• Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: a case series.
  Resuscitation 2012 Behrends M, Niemann CU, Larson MD
• Pupillometry to guide postoperative analgesia.
  Anesthesiology 2012 Larson MD, Sessler DI
• Procedure-specific guidelines.
  Anesthesiology 2010 Stites-Hallett N, Larson MD
• The effect of ketamine and nitrous oxide on the human pupillary light reflex during general anesthesia.
  Autonomic neuroscience : basic & clinical 2009 Eilers H, Larson MD
• Mechanism of opioid-induced pupillary effects.
  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2008 Larson MD
• Efficacy of epidural block during general anesthesia.
  Anesthesiology 2006 Larson MD, Fung RS, Infosino AJ, Baba A
• Induction rooms.
  Bulletin of anesthesia history 2006 Larson MD, Senturk M
• Evaluation of the portable infrared pupillometer.
  Neurosurgery 2005 Du R, Meeker M, Bacchetti P, Larson MD, Holland MC, Manley GT
• Tolerance to miotic effects of opioids.
  Anesthesiology 2005 Kollars JP, Larson MD
• Pupil examination: validity and clinical utility of an automated pupillometer.
  The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 2005 Meeker M, Du R, Bacchetti P, Privitera CM, Larson MD, Holland MC, Manley G
• Latency of pupillary reflex dilation during general anesthesia.
  Journal of applied physiology (Bethesda, Md. : 1985) 2004 Larson MD, Berry PD, May J, Bjorksten A, Sessler DI
• Mechanism of pupillary reflex dilation in awake volunteers and in organ donors.
  Anesthesiology 2003 Yang LL, Niemann CU, Larson MD
• The effect of antiemetics on pupillary reflex dilation during epidural/general anesthesia.
  Anesthesia and analgesia 2003 Larson MD
• Effect of asphyxia on the pupils of brain dead subjects.
  Resuscitation 2002 Larson MD, May J
• Infrared pupillometry during uncal herniation.
  Journal of neurosurgical anesthesiology 2002 Manley GT, Larson MD
• The effect of opioids on thermoregulatory responses in humans and the special antishivering action of meperidine.
  Annals of the New York Academy of Sciences 1997 Ikeda T, Kurz A, Sessler DI, Go J, Kurz M, Belani K, Larson M, Bjorksten AR, Dechert M, Christensen R
• Alteration of Human Pupillary Light Reflex by General Anesthesia
  Anesthesiology Review 1989 Larson, Merlin D.
• Anaesthesia
  Miotic effects of Opioids 1987 Larson, Merlin D.
• Pupillary Effects of General Anesthesia
  Anesthesiology Review 1985 Larson, Merlin D.