Mercedes Paredes, MD, PhD
Associate Professor
Neurology
School of Medicine

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California 2017
• Ph.D. Graduate Division (Neuroscience) University of California, San Francisco 2007
• M.D. Medicine University of California, San Francisco 2007

Grants and Projects

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• Gyrencephalic Model for Neurodevelopmental Disease and Postnatal Cortical Therapeutic Interventions, NIH, 2020-2025
• Late-migrating interneurons in the postnatal brain, NIH, 2015-2021

Publications (53)

Top publication keywords:
Chemokines, CXCNeural Stem CellsCerebral CortexNeurogenesisProsencephalongamma-Aminobutyric AcidMedian EminenceNervous System MalformationsHippocampusFrontal LobeNeocortexCell MovementChoristomaInterneuronsNeurons

• Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1.
  bioRxiv : the preprint server for biology 2024 Yu D, Jain S, Wangzhou A, De Florencio S, Zhu B, Kim JY, Choi JJ, Paredes MF, Nowakowski TJ, Huang EJ, Piao X
• Temporally distinct 3D multi-omic dynamics in the developing human brain.
  Nature 2024 Heffel MG, Zhou J, Zhang Y, Lee DS, Hou K, Pastor-Alonso O, Abuhanna KD, Galasso J, Kern C, Tai CY, Garcia-Padilla C, Nafisi M, Zhou Y, Schmitt AD, Li T, Haeussler M, Wick B, Zhang MJ, Xie F, Ziffra …
• Molecular and cellular dynamics of the developing human neocortex at single-cell resolution.
  bioRxiv : the preprint server for biology 2024 Wang L, Wang C, Moriano JA, Chen S, Zuo G, Cebrián-Silla A, Zhang S, Mukhtar T, Wang S, Song M, de Oliveira LG, Bi Q, Augustin JJ, Ge X, Paredes MF, Huang EJ, Alvarez-Buylla A, Duan X, Li J, …
• Conservation, alteration, and redistribution of mammalian striatal interneurons.
  bioRxiv : the preprint server for biology 2024 Corrigan EK, DeBerardine M, Poddar A, Turrero García M, Schmitz MT, Harwell CC, Paredes MF, Krienen FM, Pollen AA
• Large-scale neurophysiology and single-cell profiling in human neuroscience.
  Nature 2024 Lee AT, Chang EF, Paredes MF, Nowakowski TJ

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• Cell-Type Specificity of Mosaic Chromosome 1q Gain Resolved by snRNA-seq in a Case of Epilepsy With Hyaline Protoplasmic Astrocytopathy.
  Neurology. Genetics 2024 Leng K, Cadwell CR, Devine WP, Tihan T, Qi Z, Singhal NS, Glenn OA, Kamiya S, Wiita AP, Berger AC, Shieh JT, Titus EW, Paredes MF, Upadhyay V
• Cell type specificity of mosaic chromosome 1q gain resolved by snRNA-seq in a case of epilepsy with hyaline protoplasmic astrocytopathy.
  bioRxiv : the preprint server for biology 2024 Leng K, Cadwell CR, Patrick Devine W, Tihan T, Qi Z, Singhal N, Glenn O, Kamiya S, Wiita A, Berger A, Shieh JT, Titus EW, Paredes MF, Upadhyay V
• β-Adrenergic Signaling Promotes Morphological Maturation of Astrocytes in Female Mice.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Rosenberg MF, Godoy MI, Wade SD, Paredes MF, Zhang Y, Molofsky AV
• Single-cell analysis of prenatal and postnatal human cortical development.
  Science (New York, N.Y.) 2023 Velmeshev D, Perez Y, Yan Z, Valencia JE, Castaneda-Castellanos DR, Wang L, Schirmer L, Mayer S, Wick B, Wang S, Nowakowski TJ, Paredes M, Huang EJ, Kriegstein AR
• A cross-species proteomic map reveals neoteny of human synapse development.
  Nature 2023 Wang L, Pang K, Zhou L, Cebrián-Silla A, González-Granero S, Wang S, Bi Q, White ML, Ho B, Li J, Li T, Perez Y, Huang EJ, Winkler EA, Paredes MF, Kovner R, Sestan N, Pollen AA, Liu P, Li J, Piao X, …
• A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion.
  Scientific reports 2023 Paranjape N, Lin YT, Flores-Ramirez Q, Sarin V, Johnson AB, Chu J, Paredes M, Wiita AP
• Cell Migration in the Mammalian Cortex.
  2022 Jae Yeon Kim, Samuel J. Pleasure, Mercedes F. Paredes
• Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain.
  Cell 2022 Crouch EE, Bhaduri A, Andrews MG, Cebrian-Silla A, Diafos LN, Birrueta JO, Wedderburn-Pugh K, Valenzuela EJ, Bennett NK, Eze UC, Sandoval-Espinosa C, Chen J, Mora C, Ross JM, Howard CE, Gonzalez-…
• Cell Migration in the Mammalian Cortex.
  2022 Jae Yeon Kim, Samuel J. Pleasure, Mercedes F. Paredes
• Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis".
  Science (New York, N.Y.) 2022 Alvarez-Buylla A, Cebrian-Silla A, Sorrells SF, Nascimento MA, Paredes MF, Garcia-Verdugo JM, Yang Z, Huang EJ
• The development and evolution of inhibitory neurons in primate cerebrum.
  Nature 2022 Schmitz MT, Sandoval K, Chen CP, Mostajo-Radji MA, Seeley WW, Nowakowski TJ, Ye CJ, Paredes MF, Pollen AA
• Amplification of human interneuron progenitors promotes brain tumors and neurological defects.
  Science (New York, N.Y.) 2022 Eichmüller OL, Corsini NS, Vértesy Á, Morassut I, Scholl T, Gruber VE, Peer AM, Chu J, Novatchkova M, Hainfellner JA, Paredes MF, Feucht M, Knoblich JA
• Nests of dividing neuroblasts sustain interneuron production for the developing human brain.
  Science (New York, N.Y.) 2022 Paredes MF, Mora C, Flores-Ramirez Q, Cebrian-Silla A, Del Dosso A, Larimer P, Chen J, Kang G, Gonzalez Granero S, Garcia E, Chu J, Delgado R, Cotter JA, Tang V, Spatazza J, Obernier K, Ferrer Lozano …
• Simplified risk-prediction for benchmarking and quality improvement in emergency general surgery. Prospective, multicenter, observational cohort study.
  International journal of surgery (London, England) 2021 Villodre C, Taccogna L, Zapater P, Cantó M, Mena L, Ramia JM, Lluís F, Afonso N, Aguilella V, Aguiló J, Alados JC, Alberich M, Apio AB, Balongo R, Bra E, Bravo-Gutiérrez A, Briceño FJ, Cabañas J, …
• Implications of Extended Inhibitory Neuron Development.
  International journal of molecular sciences 2021 Kim JY, Paredes MF
• Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Sorrells SF, Paredes MF, Zhang Z, Kang G, Pastor-Alonso O, Biagiotti S, Page CE, Sandoval K, Knox A, Connolly A, Huang EJ, Garcia-Verdugo JM, Oldham MC, Yang Z, Alvarez-Buylla A
• Interneuron Origins in the Embryonic Porcine Medial Ganglionic Eminence.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Casalia ML, Li T, Ramsay H, Ross PJ, Paredes MF, Baraban SC
• Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon.
  Cell reports 2020 Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J
• Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation.
  eLife 2020 Pai EL, Chen J, Fazel Darbandi S, Cho FS, Chen J, Lindtner S, Chu JS, Paz JT, Vogt D, Paredes MF, Rubenstein JL
• Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map.
  Nature neuroscience 2020 Bayraktar OA, Bartels T, Holmqvist S, Kleshchevnikov V, Martirosyan A, Polioudakis D, Ben Haim L, Young AMH, Batiuk MY, Prakash K, Brown A, Roberts K, Paredes MF, Kawaguchi R, Stockley JH, Sabeur K, …
• Cortical Malformations: Lessons in Human Brain Development.
  Frontiers in cellular neuroscience 2020 Subramanian L, Calcagnotto ME, Paredes MF
• Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.
  Brain communications 2019 Miller ZA, Spina S, Pakvasa M, Rosenberg L, Watson C, Mandelli ML, Paredes MF, Joie R, Rabinovici GD, Rosen HJ, Grinberg LT, Huang EJ, Miller BL, Seeley WW, Gorno-Tempini ML
• Building Bridges Between the Clinic and the Laboratory: A Meeting Review - Brain Malformations: A Roadmap for Future Research.
  Frontiers in cellular neuroscience 2019 Sapir T, Barakat TS, Paredes MF, Lerman-Sagie T, Aronica E, Klonowski W, Nguyen L, Ben Zeev B, Bahi-Buisson N, Leventer R, Rachmian N, Reiner O
• Immature excitatory neurons develop during adolescence in the human amygdala.
  Nature communications 2019 Sorrells SF, Paredes MF, Velmeshev D, Herranz-Pérez V, Sandoval K, Mayer S, Chang EF, Insausti R, Kriegstein AR, Rubenstein JL, Manuel Garcia-Verdugo J, Huang EJ, Alvarez-Buylla A
• Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex.
  Neuron 2019 Mayer S, Chen J, Velmeshev D, Mayer A, Eze UC, Bhaduri A, Cunha CE, Jung D, Arjun A, Li E, Alvarado B, Wang S, Lovegren N, Gonzales ML, Szpankowski L, Leyrat A, West JAA, Panagiotakos G, Alvarez-…
• Does Adult Neurogenesis Persist in the Human Hippocampus?
  Cell stem cell 2018 Paredes MF, Sorrells SF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez Martin AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-…
• Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity.
  Cerebral cortex (New York, N.Y. : 1991) 2018 Raju CS, Spatazza J, Stanco A, Larimer P, Sorrells SF, Kelley KW, Nicholas CR, Paredes MF, Lui JH, Hasenstaub AR, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL, Oldham MC
• Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.
  Nature 2018 Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM,…
• Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism.
  Cell reports 2018 Priya R, Paredes MF, Karayannis T, Yusuf N, Liu X, Jaglin X, Graef I, Alvarez-Buylla A, Fishell G
• No Evidence For New Adult Neurons.
  American Scientist 2018 Shawn Sorrells, Arturo Alvarez-Buylla, Mercedes Paredes
• Dynamic behaviour of human neuroepithelial cells in the developing forebrain.
  Nature communications 2017 Subramanian L, Bershteyn M, Paredes MF, Kriegstein AR
• Extensive migration of young neurons into the infant human frontal lobe.
  Science (New York, N.Y.) 2016 Paredes MF, James D, Gil-Perotin S, Kim H, Cotter JA, Ng C, Sandoval K, Rowitch DH, Xu D, McQuillen PS, Garcia-Verdugo JM, Huang EJ, Alvarez-Buylla A
• Brain size and limits to adult neurogenesis.
  The Journal of comparative neurology 2015 Paredes MF, Sorrells SF, Garcia-Verdugo JM, Alvarez-Buylla A
• Encephalitis and AMPA receptor antibodies: Novel findings in a case series of 22 patients.
  Neurology 2015 Höftberger R, van Sonderen A, Leypoldt F, Houghton D, Geschwind M, Gelfand J, Paredes M, Sabater L, Saiz A, Titulaer MJ, Graus F, Dalmau J
• DISTINCT AND SEPARABLE ROLES FOR HISTONE METHYLTRANSFERASE EZH2 IN NEUROGENIC ASTROCYTES.
  Neuro-Oncology 2014 D. A. Lim, W. W. Hwang, R. D. Salinas, J. J. Siu, K. W. Kelley, R. N. Delgado, M. F. Paredes, A. Alvarez-Buylla, M. C. Oldham, D. A. Lim
• Distinct and separable roles for EZH2 in neurogenic astroglia.
  eLife 2014 Hwang WW, Salinas RD, Siu JJ, Kelley KW, Delgado RN, Paredes MF, Alvarez-Buylla A, Oldham MC, Lim DA
• Persistent abdominal symptoms in US adults after short-term stay in Mexico.
  Journal of travel medicine 2014 Nair P, Okhuysen PC, Jiang ZD, Carlin LG, Belkind-Gerson J, Flores J, Paredes M, DuPont HL
• Axons take a dive: Specialized contacts of serotonergic axons with cells in the walls of the lateral ventricles in mice and humans.
  Neurogenesis (Austin, Tex.) 2014 Tong CK, Cebrián-Silla A, Paredes MF, Huang EJ, García-Verdugo JM, Alvarez-Buylla A
• Intrinsically determined cell death of developing cortical interneurons.
  Nature 2012 Southwell DG, Paredes MF, Galvao RP, Jones DL, Froemke RC, Sebe JY, Alfaro-Cervello C, Tang Y, Garcia-Verdugo JM, Rubenstein JL, Baraban SC, Alvarez-Buylla A
• Campylobacter jejuni is not an important pathogen as a cause of diarrhea in US travelers to Mexico.
  Journal of travel medicine 2010 Villa NA, Okhuysen PC, Flores-Figueroa J, Jiang ZD, Belkind-Gerson J, Paredes M, Mohamed JA, Nair P, Carlin L, DuPont HL
• Hilar mossy cells share developmental influences with dentate granule neurons.
  Developmental neuroscience 2007 Li G, Berger O, Han SM, Paredes M, Wu NC, Pleasure SJ
• Expression of SDF-1 and CXCR4 during reorganization of the postnatal dentate gyrus.
  Developmental neuroscience 2007 Berger O, Li G, Han SM, Paredes M, Pleasure SJ
• Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Paredes MF, Li G, Berger O, Baraban SC, Pleasure SJ
• Embryonic and early postnatal abnormalities contributing to the development of hippocampal malformations in a rodent model of dysplasia.
  The Journal of comparative neurology 2006 Paredes M, Pleasure SJ, Baraban SC
• Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Calcagnotto ME, Paredes MF, Tihan T, Barbaro NM, Baraban SC
• Neuropeptide Y modulates a G protein-coupled inwardly rectifying potassium current in the mouse hippocampus.
  Neuroscience letters 2003 Paredes MF, Greenwood J, Baraban SC
• Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Calcagnotto ME, Paredes MF, Baraban SC
• A review of gene expression patterns in the malformed brain.
  Molecular neurobiology 2002 Paredes MF, Baraban SC