Melissa Spear, PhD
Postdoctoral Scholar
Epidemiology & Biostatistics
School of Medicine

Grants and Projects

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• The Effect of Admixture Processes on the Genetic Architecture of Complex Traits, NIH, 2018-2020

Publications (6)

Top publication keywords:
Mexican AmericansGenetics, PopulationModels, GeneticPuerto RicoBronchodilator AgentsVital CapacityMultifactorial InheritanceAnxietyAsthmaHuman MigrationStress, PsychologicalLinkage DisequilibriumGenome-Wide Association StudyReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type ILinear Models

• Recent shifts in the genomic ancestry of Mexican Americans may alter the genetic architecture of biomedical traits.
  eLife 2020 Spear ML, Diaz-Papkovich A, Ziv E, Yracheta JM, Gravel S, Torgerson DG, Hernandez RD
• Ebola virus, but not Marburg virus, replicates efficiently and without required adaptation in snake cells.
  Virus evolution 2018 Fedewa G, Radoshitzky SR, Chi X, Dong L, Zeng X, Spear M, Strauli N, Ng M, Chandran K, Stenglein MD, Hernandez RD, Jahrling PB, Kuhn JH, DeRisi JL
• A genome-wide association and admixture mapping study of bronchodilator drug response in African Americans with asthma.
  The pharmacogenomics journal 2018 Spear ML, Hu D, Pino-Yanes M, Huntsman S, Eng C, Levin AM, Ortega VE, White MJ, McGarry ME, Thakur N, Galanter J, Mak ACY, Oh SS, Ampleford E, Peters SP, Davis A, Kumar R, Farber HJ, Meade K, Avila PC…
• The Effects of Migration and Assortative Mating on Admixture Linkage Disequilibrium.
  Genetics 2016 Zaitlen N, Huntsman S, Hu D, Spear M, Eng C, Oh SS, White MJ, Mak A, Davis A, Meade K, Brigino-Buenaventura E, LeNoir MA, Bibbins-Domingo K, Burchard EG, Halperin E
• A Genome-Wide Association Study of Post-bronchodilator Lung Function in Children with Asthma.
  American journal of respiratory and critical care medicine 2015 Brehm JM, Man Tse S, Croteau-Chonka DC, Forno E, Litonjua AA, Raby BA, Chen W, Yan Q, Boutaoui N, Acosta-Pérez E, Avila L, Weiss ST, Soto-Quiros M, Cloutier MM, Hu D, Pino-Yanes M, Wenzel SE, Spear ML…
• Stress and Bronchodilator Response in Children with Asthma.
  American journal of respiratory and critical care medicine 2015 Brehm JM, Ramratnam SK, Tse SM, Croteau-Chonka DC, Pino-Yanes M, Rosas-Salazar C, Litonjua AA, Raby BA, Boutaoui N, Han YY, Chen W, Forno E, Marsland AL, Nugent NR, Eng C, Colón-Semidey A, Alvarez M, …