Melike Pekmezci, MD
Associate Professor
Pathology
School of Medicine

Pekmezci's research involves using molecular features to classify and grade tumors (growths of abnormal tissue), which helps with predicting how quickly a particular growth may enlarge or spread. She seeks to identify diagnostic and prognostic markers, with the goal of improving management and treatment of conditions related to these tumors.

Pekmezci earned her medical degree from Hacettepe University Faculty of Medicine in Ankara, Turkey. She did two-years of postgraduate training in clinical ophthalmology in Gazi University in Ankara, Turkey. She completed a residency in anatomical pathology and fellowships in surgical pathology and neuropathology at UCSF.

Pekmezci is a member of the United States & Canadian Academy of Pathology, American Association of Neuropathologists, Verhoeff-Zimmerman Society, and American Association of Ophthalmic Oncologists and Pathologists. She has published more than 75 peer-reviewed manuscripts on brain and eye diseases, along with numerous case reports, book chapters and reviews.

• Revised Diagnosis From Histiocytic Neoplasm to Optic Chiasm Glioblastoma After Genetic Analysis.
  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2024 Magharious MM, Pekmezci M, Mamlouk MD, Horton JC, Levin MH
• Utility of PD-1, PD-L1, and IDO-1 Stains in Ocular Extranodal Marginal Zone Lymphoma (MZL) and Diffuse Large B-cell Lymphoma (DLBCL).
  Applied immunohistochemistry & molecular morphology : AIMM 2024 Craig A, Güney E, Pekmezci M, Bloomer M, Laszik Z, Ohgami RS, Toland A, Vogel H, Forns T, Wang E, Rubenstein J, Wen KW
• Pembrolizumab in an HIV-infected patient with glioblastoma.
  Immunotherapy 2024 Yuen CA, Bao S, Pekmezci M, Mo F, Kong XT
• Metastatic glioblastoma to the lungs: a case report and literature review.
  CNS oncology 2024 Yuen CA, Pekmezci M, Bao S, Kong XT
• Stromal Keratitis Associated With Cytomegalovirus Anterior Uveitis.
  Cornea 2024 Pisitpayat P, Mentreddy A, Pekmezci M, Hwang D, Shantha J, Benador-Shen C, Terry M, Pothikamjorn T, Gonzales J
• Epigenetic reprogramming shapes the cellular landscape of schwannoma.
  Nature communications 2024 Liu SJ, Casey-Clyde T, Cho NW, Swinderman J, Pekmezci M, Dougherty MC, Foster K, Chen WC, Villanueva-Meyer JE, Swaney DL, Vasudevan HN, Choudhury A, Pak J, Breshears JD, Lang UE, Eaton CD, Hiam-Galvez…
• Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance.
  Nature communications 2024 Vasudevan HN, Payne E, Delley CL, John Liu S, Mirchia K, Sale MJ, Lastella S, Nunez MS, Lucas CG, Eaton CD, Casey-Clyde T, Magill ST, Chen WC, Braunstein SE, Perry A, Jacques L, Reddy AT, Pekmezci M, …
• "De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.
  Acta neuropathologica 2023 Hadad S, Gupta R, Oberheim Bush NA, Taylor JW, Villanueva-Meyer JE, Young JS, Wu J, Ravindranathan A, Zhang Y, Warrier G, McCoy L, Shai A, Pekmezci M, Perry A, Bollen AW, Phillips JJ, Braunstein SE, …
• Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs.
  Neuro-oncology 2023 Williams EA, Ravindranathan A, Gupta R, Stevers NO, Suwala AK, Hong C, Kim S, Yuan JB, Wu J, Barreto J, Lucas CG, Chan E, Pekmezci M, LeBoit PE, Mully T, Perry A, Bollen A, Van Ziffle J, Devine WP, …
• Pathological perspectives in pilocytic astrocytomas: Extent of resection as the sole critical factor for recurrence-free survival, and the challenge of evaluating conclusions derived from limited data.
  Free neuropathology 2023 Kulac I, Yenidogan I, Oflaz Sozmen B, Baygul A, Cha S, Pekmezci M, Tihan T
• Poorly differentiated orbital neuroendocrine carcinoma.
  BMJ case reports 2023 Zhang YS, Jiro M, Pekmezci M, Winn B
• Molecular profiling identifies at least 3 distinct types of posttransplant lymphoproliferative disorder involving the CNS.
  Blood advances 2023 Guney E, Lucas CG, Singh K, Pekmezci M, Fernandez-Pol S, Mirchia K, Toland A, Vogel H, Bannykh S, Schafernak KT, Alexandrescu S, Mobley BC, Powell S, Davidson CJ, Neltner J, Boué DR, Hattab E, Ferris …
• Next-generation sequencing of a large uveal melanoma with whole genome doubling and a PBRM1 mutation.
  American journal of ophthalmology case reports 2023 Ahmad TR, Pekmezci M, Bloomer MM, Grenert JP, Afshar AR
• A Case of Orbital Sarcoidosis with Caseating Granulomatous Inflammation.
  Ophthalmic plastic and reconstructive surgery 2023 Meer E, Ahmad M, Pekmezci M, Kersten RC
• Sarcomatous Transformation of a Medically Treated Lactotroph Pituitary Neuroendocrine Tumor?
  Endocrine pathology 2023 Terry M, Reis G, Horvai A, Pekmezci M, Perry A
• Prognostic Value of BAP1 and Preferentially Expressed Antigen in Melanoma (PRAME) Immunohistochemistry in Uveal Melanomas.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2023 Han LM, Lee KW, Uludag G, Seider MI, Afshar AR, Bloomer MM, Pekmezci M
• Rapid pre-retinal ossification presenting as a vascularized lesion over an area of chronic retinal detachment.
  American journal of ophthalmology case reports 2022 Ma CJ, Pekmezci M, Stewart JM
• Uterine Inflammatory Myofibroblastic Tumors: Proposed Risk Stratification Model Using Integrated Clinicopathologic and Molecular Analysis.
  The American journal of surgical pathology 2022 Ladwig NR, Bean GR, Pekmezci M, Boscardin J, Joseph NM, Therrien N, Sangoi AR, Piening B, Rajamanickam V, Galvin M, Bernard B, Zaloudek C, Rabban JT, Garg K, Umetsu SE
• Prospective genomically guided identification of "early/evolving" and "undersampled" IDH-wildtype glioblastoma leads to improved clinical outcomes.
  Neuro-oncology 2022 Zhang Y, Lucas CG, Young JS, Morshed RA, McCoy L, Oberheim Bush NA, Taylor JW, Daras M, Butowski NA, Villanueva-Meyer JE, Cha S, Wrensch M, Wiencke JK, Lee JC, Pekmezci M, Phillips JJ, Perry A, Bollen…
• Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1.
  Acta neuropathologica 2022 Lucas CG, Sloan EA, Gupta R, Wu J, Pratt D, Vasudevan HN, Ravindranathan A, Barreto J, Williams EA, Shai A, Whipple NS, Bruggers CS, Maher O, Nabors B, Rodriguez M, Samuel D, Brown M, Carmichael J, Lu…
• Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma.
  Journal of neuropathology and experimental neurology 2022 Lucas CG, Davidson CJ, Alashari M, Putnam AR, Whipple NS, Bruggers CS, Mendez JS, Cheshier SH, Walker JB, Ramani B, Cadwell CR, Sullivan DV, Lu R, Mirchia K, Van Ziffle J, Devine P, Goldschmidt E, …
• Iris and Ciliary Body Melanocytomas Are Defined by Solitary GNAQ Mutation Without Additional Oncogenic Alterations.
  Ophthalmology 2022 Solomon DA, Ramani B, Eiger-Moscovich M, Milman T, Uludag G, Crawford JB, Phan I, Char DH, Shields CL, Eagle RC, Bastian BC, Bloomer MM, Pekmezci M
• Intratumor and informatic heterogeneity influence meningioma molecular classification.
  Acta neuropathologica 2022 Vasudevan HN, Choudhury A, Hilz S, Villanueva-Meyer JE, Chen WC, Lucas CG, Braunstein SE, Oberheim Bush NA, Butowski N, Pekmezci M, McDermott MW, Perry A, Solomon DA, Magill ST, Raleigh DR
• TRAF7 somatic mosaicism in a patient with bilateral optic nerve sheath meningiomas: illustrative case.
  Journal of neurosurgery. Case lessons 2022 Kaidonis G, Pekmezci M, Van Ziffle J, Auguste KI, Horton JC
• A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome.
  Blood advances 2022 Güney E, Lucas CG, Qi Z, Yu J, Zhang R, Ohgami RS, Rubenstein JL, Boué DR, Schafernak K, Wertheim GB, Dahiya S, Giulino-Roth L, Attarbaschi A, Barth MJ, Kothari S, Abla O, Cohen AL, Mendez JS, Bollen …
• Plexiform Neurofibroma With Activating KRAS Mutation and Segmental Presentation Involving the Unilateral Eyelid.
  Ophthalmic plastic and reconstructive surgery 2022 Stallworth JY, Smith LD, Vagefi MR, Pekmezci M
• Towards Development of a Standard Terminology of the World Health Organization Classification of Tumors of the Central Nervous System in the Turkish Language, and a Perspective on the Practical Implications of the WHO Classification for Low and Middle Income Countries.
  Turk patoloji dergisi 2022 Soylemezoglu F, Oz B, Egilmez R, Pekmezci M, Bozkurt S, Danyeli AE, Onguru O, Kulac I, Tihan T
• Intracranial mesenchymal tumors with FET-CREB fusion are composed of at least two epigenetic subgroups distinct from meningioma and extracranial sarcomas.
  Brain pathology (Zurich, Switzerland) 2021 Sloan EA, Gupta R, Koelsche C, Chiang J, Villanueva-Meyer JE, Alexandrescu S, Eschbacher JM, Wang W, Mafra M, Ud Din N, Carr-Boyd E, Watson M, Punsoni M, Oviedo A, Gilani A, Kleinschmidt-DeMasters BK,…
• Correction: Aberrant ATRX protein expression is associated with poor overall survival in NF1-MPNST.
  Oncotarget 2021 Lu HC, Eulo V, Apicelli AJ, Pekmezci M, Tao Y, Luo J, Hirbe AC, Dahiya S
• Detection of glioma infiltration at the tumor margin using quantitative stimulated Raman scattering histology.
  Scientific reports 2021 Pekmezci M, Morshed RA, Chunduru P, Pandian B, Young J, Villanueva-Meyer JE, Tihan T, Sloan EA, Aghi MK, Molinaro AM, Berger MS, Hervey-Jumper SL
• Preferentially Expressed Antigen in Melanoma (PRAME) Expression in Malignant, but Not Benign, Peripheral Nerve Sheath Tumors.
  Journal of neuropathology and experimental neurology 2021 Cadwell CR, Yuksek GE, Hirbe AC, Srihari D, LeBoit P, Dahiya S, Pekmezci M
• Loss of fidelity in scanned digital images compared to glass slides of brain tumors resected using cavitron ultrasonic surgical aspirator.
  Brain pathology (Zurich, Switzerland) 2021 Cadwell CR, Bowman S, Laszik ZG, Pekmezci M
• Intracranial mesenchymal tumor with FET-CREB fusion-A unifying diagnosis for the spectrum of intracranial myxoid mesenchymal tumors and angiomatoid fibrous histiocytoma-like neoplasms.
  Brain pathology (Zurich, Switzerland) 2021 Sloan EA, Chiang J, Villanueva-Meyer JE, Alexandrescu S, Eschbacher JM, Wang W, Mafra M, Ud Din N, Carr-Boyd E, Watson M, Punsoni M, Oviedo A, Gilani A, Kleinschmidt-DeMasters BK, Coss DJ, Lopes MB, …
• A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection.
  Neurosurgery 2020 Chen WC, Vasudevan HN, Choudhury A, Pekmezci M, Lucas CG, Phillips J, Magill ST, Susko MS, Braunstein SE, Oberheim Bush NA, Boreta L, Nakamura JL, Villanueva-Meyer JE, Sneed PK, Perry A, McDermott MW,…
• Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1.
  Acta neuropathologica 2020 Sievers P, Sill M, Blume C, Tauziede-Espariat A, Schrimpf D, Stichel D, Reuss DE, Dogan H, Hartmann C, Mawrin C, Hasselblatt M, Stummer W, Schick U, Hench J, Frank S, Ketter R, Schweizer L, …
• Adult diffuse glioma GWAS by molecular subtype identifies variants in D2HGDH and FAM20C.
  Neuro-oncology 2020 Eckel-Passow JE, Drucker KL, Kollmeyer TM, Kosel ML, Decker PA, Molinaro AM, Rice T, Praska CE, Clark L, Caron A, Abyzov A, Batzler A, Song JS, Pekmezci M, Hansen HM, McCoy LS, Bracci PM, Wiemels J, …
• Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma.
  Acta neuropathologica communications 2020 Zhang C, Ostrom QT, Semmes EC, Ramaswamy V, Hansen HM, Morimoto L, de Smith AJ, Pekmezci M, Vaksman Z, Hakonarson H, Diskin SJ, Metayer C, Glioma International Case-Control Study (GICC), Taylor MD, …
• Clinical, radiologic, and genetic characteristics of histone H3 K27M-mutant diffuse midline gliomas in adults.
  Neuro-oncology advances 2020 Schulte JD, Buerki RA, Lapointe S, Molinaro AM, Zhang Y, Villanueva-Meyer JE, Perry A, Phillips JJ, Tihan T, Bollen AW, Pekmezci M, Butowski N, Oberheim Bush NA, Taylor JW, Chang SM, Theodosopoulos P,…
• Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival.
  Neuro-oncology advances 2020 Lucas CG, Vasudevan HN, Chen WC, Magill ST, Braunstein SE, Jacques L, Dahiya S, Rodriguez FJ, Horvai AE, Perry A, Pekmezci M, Raleigh DR
• Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.
  Nature communications 2020 Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, …
• The immunohistochemical, DNA methylation, and chromosomal copy number profile of cauda equina paraganglioma is distinct from extra-spinal paraganglioma.
  Acta neuropathologica 2020 Ramani B, Gupta R, Wu J, Barreto J, Bollen AW, Tihan T, Mummaneni PV, Ames C, Clark A, Oberheim Bush NA, Butowski N, Phillips D, King BE, Bator SM, Treynor EC, Zherebitskiy V, Quinn PS, Walker JB, …
• Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor.
  Acta neuropathologica communications 2020 Lucas CG, Gupta R, Doo P, Lee JC, Cadwell CR, Ramani B, Hofmann JW, Sloan EA, Kleinschmidt-DeMasters BK, Lee HS, Wood MD, Grafe M, Born D, Vogel H, Salamat S, Puccetti D, Scharnhorst D, Samuel D, …
• Pediatric meningioma: a clinicopathologic and molecular study with potential grading implications.
  Brain pathology (Zurich, Switzerland) 2020 Toland A, McNulty SN, Pekmezci M, Evenson M, Huntoon K, Pierson CR, Boue DR, Perry A, Dahiya S
• The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies.
  Cancer discovery 2020 Prager BC, Vasudevan HN, Dixit D, Bernatchez JA, Wu Q, Wallace LC, Bhargava S, Lee D, King BH, Morton AR, Gimple RC, Pekmezci M, Zhu Z, Siqueira-Neto JL, Wang X, Xie Q, Chen C, Barnett GH, Vogelbaum …
• Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals.
  Acta neuropathologica communications 2020 Findakly S, Choudhury A, Daggubati V, Pekmezci M, Lang UE, Raleigh DR
• Pituitary neuroendocrine tumors (PitNETs): nomenclature evolution, not clinical revolution.
  Pituitary 2020 Asa SL, Asioli S, Bozkurt S, Casar-Borota O, Chinezu L, Comunoglu N, Cossu G, Cusimano M, Delgrange E, Earls P, Ezzat S, Gazioglu N, Grossman A, Guaraldi F, Hickman RA, Ikeda H, Jaffrain-Rea ML, …
• Histologic Changes Following Continuous Wave and Micropulse Transscleral Cyclophotocoagulation: A Randomized Comparative Study.
  Translational vision science & technology 2020 Moussa K, Feinstein M, Pekmezci M, Lee JH, Bloomer M, Oldenburg C, Sun Z, Lee RK, Ying GS, Han Y
• Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition.
  Acta neuropathologica 2020 Mondal G, Lee JC, Ravindranathan A, Villanueva-Meyer JE, Tran QT, Allen SJ, Barreto J, Gupta R, Doo P, Van Ziffle J, Onodera C, Devine P, Grenert JP, Samuel D, Li R, Metrock LK, Jin LW, Antony R, …
• Gliomas arising in the setting of Li-Fraumeni syndrome stratify into two molecular subgroups with divergent clinicopathologic features.
  Acta neuropathologica 2020 Sloan EA, Hilz S, Gupta R, Cadwell C, Ramani B, Hofmann J, Kline CN, Banerjee A, Reddy A, Oberheim Bush NA, Chang S, Braunstein S, Chang EF, Raffel C, Gupta N, Sun PP, Kim JYH, Moes G, Alva E, Li R, …
• Loss of H3K27 trimethylation by immunohistochemistry is frequent in oligodendroglioma, IDH-mutant and 1p/19q-codeleted, but is neither a sensitive nor a specific marker.
  Acta neuropathologica 2020 Pekmezci M, Phillips JJ, Dirilenoglu F, Atasever-Rezanko T, Tihan T, Solomon D, Bollen A, Perry A
• Intracapsular High-Grade Ductal Carcinoma In-Situ Ex Pleomorphic Adenoma of the Lacrimal Gland.
  Ophthalmic plastic and reconstructive surgery 2020 Garakani R, Kersten R, Pekmezci M
• Pathology of meningiomas.
  Handbook of clinical neurology 2020 Solomon DA, Pekmezci M
• Clinicopathologic and molecular features of intracranial desmoplastic small round cell tumors.
  Brain pathology (Zurich, Switzerland) 2019 Lee JC, Villanueva-Meyer JE, Ferris SP, Cham EM, Zucker J, Cooney T, Gilani A, Kleinschmidt-DeMasters BK, Trembath D, Mafra M, Chiang J, Ellison DW, Cho SJ, Horvai AE, Van Ziffle J, Onodera C, Devine …
• Next-Generation Sequencing of Retinoblastoma Identifies Pathogenic Alterations beyond RB1 Inactivation That Correlate with Aggressive Histopathologic Features.
  Ophthalmology 2019 Afshar AR, Pekmezci M, Bloomer MM, Cadenas NJ, Stevers M, Banerjee A, Roy R, Olshen AB, Van Ziffle J, Onodera C, Devine WP, Grenert JP, Bastian BC, Solomon DA, Damato BE
• Myxoid glioneuronal tumor, PDGFRA p.K385-mutant: clinical, radiologic, and histopathologic features.
  Brain pathology (Zurich, Switzerland) 2019 Lucas CG, Villanueva-Meyer JE, Whipple N, Oberheim Bush NA, Cooney T, Chang S, McDermott M, Berger M, Cham E, Sun PP, Putnam A, Zhou H, Bollo R, Cheshier S, Poppe MM, Fung KM, Sung S, Glenn C, Fan X, …
• Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas.
  Acta neuropathologica 2019 Sloan EA, Cooney T, Oberheim Bush NA, Buerki R, Taylor J, Clarke JL, Torkildson J, Kline C, Reddy A, Mueller S, Banerjee A, Butowski N, Chang S, Mummaneni PV, Chou D, Tan L, Theodosopoulos P, …
• Whole exome sequencing reveals the maintained polyclonal nature from primary to metastatic malignant peripheral nerve sheath tumor in two patients with NF1.
  Neuro-oncology advances 2019 Godec A, Jayasinghe R, Chrisinger JSA, Prudner B, Ball T, Wang Y, Srihari D, Kaushal M, Dietz H, Zhang X, Pekmezci M, Dahiya S, Tao Y, Luo J, Van Tine BA, Ding L, Gutmann DH, Hirbe AC
• Integrated models incorporating radiologic and radiomic features predict meningioma grade, local failure, and overall survival.
  Neuro-oncology advances 2019 Morin O, Chen WC, Nassiri F, Susko M, Magill ST, Vasudevan HN, Wu A, Vallières M, Gennatas ED, Valdes G, Pekmezci M, Alcaide-Leon P, Choudhury A, Interian Y, Mortezavi S, Turgutlu K, Bush NAO, Solberg…
• Telomere alterations in neurofibromatosis type 1-associated solid tumors.
  Acta neuropathologica communications 2019 Rodriguez FJ, Graham MK, Brosnan-Cashman JA, Barber JR, Davis C, Vizcaino MA, Palsgrove DN, Giannini C, Pekmezci M, Dahiya S, Gokden M, Noë M, Wood LD, Pratilas CA, Morris CD, Belzberg A, Blakeley J, …
• High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis.
  Brain pathology (Zurich, Switzerland) 2019 Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruiz-Diaz I, Magaki S, Wilson D, Neltner J, …
• Using germline variants to estimate glioma and subtype risks.
  Neuro-oncology 2019 Eckel-Passow JE, Decker PA, Kosel ML, Kollmeyer TM, Molinaro AM, Rice T, Caron AA, Drucker KL, Praska CE, Pekmezci M, Hansen HM, McCoy LS, Bracci PM, Erickson BJ, Lucchinetti CF, Wiemels JL, Wiencke …
• Pleomorphic and Florid Lobular Carcinoma In Situ Variants of the Breast: A Clinicopathologic Study of 85 Cases With and Without Invasive Carcinoma From a Single Academic Center.
  The American journal of surgical pathology 2019 Shamir ER, Chen YY, Chu T, Pekmezci M, Rabban JT, Krings G
• Clinicopathologic features of anaplastic myxopapillary ependymomas.
  Brain pathology (Zurich, Switzerland) 2019 Lee JC, Sharifai N, Dahiya S, Kleinschmidt-DeMasters BK, Rosenblum MK, Reis GF, Samuel D, Siongco AM, Santi M, Storm PB, Ferris SP, Bollen AW, Pekmezci M, Solomon DA, Tihan T, Perry A
• Molecular features and clinical outcomes in surgically treated low-grade diffuse gliomas in patients over the age of 60.
  Journal of neuro-oncology 2018 Morshed RA, Han SJ, Hervey-Jumper SL, Pekmezci M, Troncon I, Chang SM, Butowski NA, Berger MS
• The genetic landscape of anaplastic pleomorphic xanthoastrocytoma.
  Brain pathology (Zurich, Switzerland) 2018 Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Bastian BC, Grenert JP, Kline CN, Mueller S, Banerjee A, Nicolaides T, Gupta N, Berger MS, Lee HS, Pekmezci M, Tihan T, Bollen AW, Perry A, Shieh …
• Identification of high-risk human papillomavirus and Rb/E2F pathway genomic alterations in mutually exclusive subsets of colorectal neuroendocrine carcinoma.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2018 Shamir ER, Devine WP, Pekmezci M, Umetsu SE, Krings G, Federman S, Cho SJ, Saunders TA, Jen KY, Bergsland E, Jones K, Kim GE, Kakar S, Chiu CY, Joseph NM
• The genetic landscape of gliomas arising after therapeutic radiation.
  Acta neuropathologica 2018 López GY, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Clarke J, Oberheim Bush NA, Taylor J, Chang S, Butowski N, Banerjee A, Mueller S, Kline C, Torkildson J, Samuel D, Siongco A, Raffel C…
• Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile.
  Acta neuropathologica 2018 Solomon DA, Korshunov A, Sill M, Jones DTW, Kool M, Pfister SM, Fan X, Bannykh S, Hu J, Danielpour M, Li R, Johnston J, Cham E, Cooney T, Sun PP, Oberheim Bush NA, McDermott M, Van Ziffle J, Onodera C…
• The genetic landscape of ganglioglioma.
  Acta neuropathologica communications 2018 Pekmezci M, Villanueva-Meyer JE, Goode B, Van Ziffle J, Onodera C, Grenert JP, Bastian BC, Chamyan G, Maher OM, Khatib Z, Kleinschmidt-DeMasters BK, Samuel D, Mueller S, Banerjee A, Clarke JL, Cooney …
• Aberrant ATRX protein expression is associated with poor overall survival in NF1-MPNST.
  Oncotarget 2018 Lu HC, Eulo V, Apicelli AJ, Pekmezci M, Tao Y, Luo J, Hirbe AC, Dahiya S
• Comprehensive Molecular Profiling Identifies FOXM1 as a Key Transcription Factor for Meningioma Proliferation.
  Cell reports 2018 Vasudevan HN, Braunstein SE, Phillips JJ, Pekmezci M, Tomlin BA, Wu A, Reis GF, Magill ST, Zhang J, Feng FY, Nicholaides T, Chang SM, Sneed PK, McDermott MW, Berger MS, Perry A, Raleigh DR
• Choroidal Lymphoma Discovered on Ultrasound in a Patient with Suspected Corneal Tumor.
  Ocular oncology and pathology 2018 Theophanous C, Pekmezci M, Damato BE, Kao AA, Bloomer MM, Stewart JM, Afshar AR
• Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway.
  Acta neuropathologica 2018 Pekmezci M, Stevers M, Phillips JJ, Van Ziffle J, Bastian BC, Tsankova NM, Kleinschmidt-DeMasters BK, Rosenblum MK, Tihan T, Perry A, Solomon DA
• Utility of Pit-1 Immunostaining in Distinguishing Pituitary Adenomas of Primitive Differentiation from Null Cell Adenomas.
  Endocrine pathology 2017 Lee JC, Pekmezci M, Lavezo JL, Vogel H, Katznelson L, Fraenkel M, Harsh G, Dulai M, Perry A, Tihan T
• Significance of H3K27me3 loss in the diagnosis of malignant peripheral nerve sheath tumors.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2017 Pekmezci M, Cuevas-Ocampo AK, Perry A, Horvai AE
• Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome.
  Acta neuropathologica 2017 Panwalkar P, Clark J, Ramaswamy V, Hawes D, Yang F, Dunham C, Yip S, Hukin J, Sun Y, Schipper MJ, Chavez L, Margol A, Pekmezci M, Chung C, Banda A, Bayliss JM, Curry SJ, Santi M, Rodriguez FJ, Snuderl…
• Apparent diffusion coefficient and pituitary macroadenomas: pre-operative assessment of tumor atypia.
  Pituitary 2017 Tamrazi B, Pekmezci M, Aboian M, Tihan T, Glastonbury CM
• Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT.
  Acta neuropathologica 2017 Pekmezci M, Rice T, Molinaro AM, Walsh KM, Decker PA, Hansen H, Sicotte H, Kollmeyer TM, McCoy LS, Sarkar G, Perry A, Giannini C, Tihan T, Berger MS, Wiemels JL, Bracci PM, Eckel-Passow JE, Lachance …
• Erratum to: Surgical resection of fourth ventricular ependymomas: case series and technical nuances.
  Journal of neuro-oncology 2017 Winkler EA, Birk H, Safaee M, Yue JK, Burke JF, Viner JA, Pekmezci M, Perry A, Aghi MK, Berger MS, McDermott MW
• Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas.
  Science translational medicine 2016 Bayliss J, Mukherjee P, Lu C, Jain SU, Chung C, Martinez D, Sabari B, Margol AS, Panwalkar P, Parolia A, Pekmezci M, McEachin RC, Cieslik M, Tamrazi B, Garcia BA, La Rocca G, Santi M, Lewis PW, …
• Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.
  Cancer 2016 Hirbe AC, Kaushal M, Sharma MK, Dahiya S, Pekmezci M, Perry A, Gutmann DH
• Surgical resection of fourth ventricular ependymomas: case series and technical nuances.
  Journal of neuro-oncology 2016 Winkler EA, Birk H, Safaee M, Yue JK, Burke JF, Viner JA, Pekmezci M, Perry A, Aghi MK, Berger MS, McDermott MW
• Comparision of New Diagnostic Tools for Malignant Peripheral Nerve Sheath Tumors.
  Pathology oncology research : POR 2016 Ersen A, Pekmezci M, Folpe AL, Tihan T
• Pitfalls in the use of whole slide imaging for the diagnosis of central nervous system tumors: A pilot study in surgical neuropathology.
  Journal of pathology informatics 2016 Pekmezci M, Uysal SP, Orhan Y, Tihan T, Lee HS
• Morphometric characterization of brain arteriovenous malformations for clinical and radiological studies to identify silent intralesional microhemorrhages.
  Clinical neuropathology 2016 Pekmezci M, Nelson J, Su H, Hess C, Lawton MT, Sonmez M, Young WL, Kim H, Tihan T
• SOX10 Distinguishes Pilocytic and Pilomyxoid Astrocytomas From Ependymomas but Shows No Differences in Expression Level in Ependymomas From Infants Versus Older Children or Among Molecular Subgroups.
  Journal of neuropathology and experimental neurology 2016 Kleinschmidt-DeMasters BK, Donson AM, Richmond AM, Pekmezci M, Tihan T, Foreman NK
• Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.
  The New England journal of medicine 2015 Eckel-Passow JE, Lachance DH, Molinaro AM, Walsh KM, Decker PA, Sicotte H, Pekmezci M, Rice T, Kosel ML, Smirnov IV, Sarkar G, Caron AA, Kollmeyer TM, Praska CE, Chada AR, Halder C, Hansen HM, McCoy …
• Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.
  Science (New York, N.Y.) 2015 Bell RJ, Rube HT, Kreig A, Mancini A, Fouse SD, Nagarajan RP, Choi S, Hong C, He D, Pekmezci M, Wiencke JK, Wrensch MR, Chang SM, Walsh KM, Myong S, Song JS, Costello JF
• Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Mack SC, Agnihotri S, Bertrand KC, Wang X, Shih DJ, Witt H, Hill N, Zayne K, Barszczyk M, Ramaswamy V, Remke M, Thompson Y, Ryzhova M, Massimi L, Grajkowska W, Lach B, Gupta N, Weiss WA, Guha A, …
• CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas.
  Journal of neuropathology and experimental neurology 2015 Reis GF, Pekmezci M, Hansen HM, Rice T, Marshall RE, Molinaro AM, Phillips JJ, Vogel H, Wiencke JK, Wrensch MR, Walsh KM, Perry A
• Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Hirbe AC, Dahiya S, Miller CA, Li T, Fulton RS, Zhang X, McDonald S, DeSchryver K, Duncavage EJ, Walrath J, Reilly KM, Abel HJ, Pekmezci M, Perry A, Ley TJ, Gutmann DH
• Simultaneous serum aquaporin-4 antibody and CSF NMDA receptor antibody-positive encephalitis.
  Neurology(R) neuroimmunology & neuroinflammation 2015 Orengo JP, Pekmezci M, Cree BA
• Response to "the epidemiology of glioma in adults: a 'state of the science' review".
  Neuro-oncology 2015 Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, Wrensch MR, Barnholtz-Sloan JS
• HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth.
  Cell reports 2015 Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo PF, Costello JF, Aghi MK, Maltepe E
• Practical molecular pathologic diagnosis of infiltrating gliomas.
  Surgical pathology clinics 2014 Pekmezci M, Perry A
• Low-grade small round cell tumor of the cauda equina with EWSR1-WT1 fusion and indolent clinical course.
  Human pathology 2014 Ud Din N, Pekmezci M, Javed G, Horvai AE, Ahmad Z, Faheem M, Navarro AL, López-Terrada D, Perry A
• Genetic markers in adult high-grade gliomas.
  Seminars in radiation oncology 2014 Pekmezci M, Perry A
• Optic nerve diffusion tensor imaging parameters and their correlation with optic disc topography and disease severity in adult glaucoma patients and controls.
  Journal of glaucoma 2014 Chang ST, Xu J, Trinkaus K, Pekmezci M, Arthur SN, Song SK, Barnett EM
• Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2014 Pekmezci M, Reuss DE, Hirbe AC, Dahiya S, Gutmann DH, von Deimling A, Horvai AE, Perry A
• Risk factors for glaucoma suspicion in healthy young asian and caucasian americans.
  Journal of ophthalmology 2014 Doss EL, Doss L, Han Y, Huang S, Porco T, Pekmezci M, Lin S
• The epidemiology of glioma in adults: a "state of the science" review.
  Neuro-oncology 2014 Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, Wrensch MR, Barnholtz-Sloan JS
• Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
  Nature genetics 2014 Walsh KM, Codd V, Smirnov IV, Rice T, Decker PA, Hansen HM, Kollmeyer T, Kosel ML, Molinaro AM, McCoy LS, Bracci PM, Cabriga BS, Pekmezci M, Zheng S, Wiemels JL, Pico AR, Tihan T, Berger MS, Chang SM,…
• Previously unrecognized pattern of central nervous system hemangiopericytoma with pseudoglandular spaces.
  Clinical neuropathology 2014 Pekmezci M, Vlodavsky E, Perry A
• Successful treatment of a very rare angiosarcoma involving the lumbar spine via en-bloc resection and radiotherapy: case report.
  Turkish neurosurgery 2014 Nacar OA, Ulu MO, Pekmezci M, Deviren V, Ames C
• BRAFV600E mutation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors.
  Neuro-oncology 2013 Hirbe AC, Pekmezci M, Dahiya S, Apicelli AJ, Van Tine BA, Perry A, Gutmann DH
• Differences in vision between clinic and home and the effect of lighting in older adults with and without glaucoma.
  JAMA ophthalmology 2013 Bhorade AM, Perlmutter MS, Wilson B, Kambarian J, Chang S, Pekmezci M, Gordon M
• Adult-Onset Fatal Neurohepatopathy in a Woman Caused by MPV17 Mutation.
  JIMD reports 2013 Mendelsohn BA, Mehta N, Hameed B, Pekmezci M, Packman S, Ralph J
• Headache and focal neurologic deficits in a 37-year-old woman.
  JAMA neurology 2013 Ayodele MO, Pekmezci M, Aghi MK, Scott BJ
• Diagnostic utility of SOX10 to distinguish malignant peripheral nerve sheath tumor from synovial sarcoma, including intraneural synovial sarcoma.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2013 Kang Y, Pekmezci M, Folpe AL, Ersen A, Horvai AE
• A comprehensive long-term retrospective analysis of silent corticotrophic adenomas vs hormone-negative adenomas.
  Neurosurgery 2013 Jahangiri A, Wagner JR, Pekmezci M, Hiniker A, Chang EF, Kunwar S, Blevins L, Aghi MK
• Neuropathology of brain metastases.
  Surgical neurology international 2013 Pekmezci M, Perry A
• Subependymal spread of recurrent glioblastoma detected with the intraoperative use of 5-aminolevulinic acid: case report.
  Journal of neurosurgery 2013 Cage TA, Pekmezci M, Prados M, Berger MS
• Evaluation of biomarkers in multifocal/multicentric invasive breast carcinomas.
  International journal of surgical pathology 2012 Pekmezci M, Szpaderska A, Osipo C, Ersahin Ç
• Comparison of optic disc parameters measured by RTVue-100 FDOCT versus HRT-II.
  Journal of glaucoma 2012 Mesiwala NK, Pekmezci M, Huang JY, Porco TC, Lin SC
• Optic disc parameters from optovue optical coherence tomography: comparison of manual versus automated disc rim determination.
  Journal of glaucoma 2012 Mesiwala NK, Pekmezci M, Porco TC, Lin SC
• Dark-light change of iris parameters and related factors among American Caucasians, American Chinese, and Mainland Chinese.
  Current eye research 2012 Wang D, He M, Wu L, Kao A, Pekmezci M, Singh K, Lin S
• The Effect of Cold Ischemia Time and/or Formalin Fixation on Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor-2 Results in Breast Carcinoma.
  Pathology research international 2012 Pekmezci M, Szpaderska A, Osipo C, Ersahin C
• The superiority of conservative resection and adjuvant radiation for craniopharyngiomas.
  Journal of neuro-oncology 2012 Schoenfeld A, Pekmezci M, Barnes MJ, Tihan T, Gupta N, Lamborn KR, Banerjee A, Mueller S, Chang S, Berger MS, Haas-Kogan D
• Emergence of a high-grade sarcoma in a recurrent meningioma: malignant progression or collision tumor?
  Archives of pathology & laboratory medicine 2011 Oz B, Pekmezci M, Dashti R, Karaman K, Kuday C, Tihan T
• Effect of measurement order between right and left eyes on intraocular pressure measurement.
  Archives of ophthalmology (Chicago, Ill. : 1960) 2011 Pekmezci M, Chang ST, Wilson BS, Gordon MO, Bhorade AM
• Diagnostic power of optic disc morphology, peripapillary retinal nerve fiber layer thickness, and macular inner retinal layer thickness in glaucoma diagnosis with fourier-domain optical coherence tomography.
  Journal of glaucoma 2011 Huang JY, Pekmezci M, Mesiwala N, Kao A, Lin S
• Neural stem cells and their role in the pathology and classification of central nervous system tumors.
  Turk patoloji dergisi 2011 Tihan T, Pekmezci M, Karnezis A
• Clinicopathological characteristics of adamantinomatous and papillary craniopharyngiomas: University of California, San Francisco experience 1985-2005.
  Neurosurgery 2010 Pekmezci M, Louie J, Gupta N, Bloomer MM, Tihan T
• Intra-examiner repeatability and agreement of corneal pachymetry map measurement by time-domain and Fourier-domain optical coherence tomography.
  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2010 Huang JY, Pekmezci M, Yaplee S, Lin S
• Resident-performed Ahmed glaucoma valve surgery.
  Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 2010 Desai RU, Pekmezci M, Tam D, Song J, Lin SC
• High prevalence of narrow angles among Chinese-American glaucoma and glaucoma suspect patients.
  Journal of glaucoma 2009 Seider MI, Pekmezci M, Han Y, Sandhu S, Kwok SY, Lee RY, Lin SC
• Optic disk size variability between African, Asian, white, Hispanic, and Filipino Americans using Heidelberg retinal tomography.
  Journal of glaucoma 2009 Seider MI, Lee RY, Wang D, Pekmezci M, Porco TC, Lin SC
• Comparison of different modes in optical coherence tomography and ultrasound biomicroscopy in anterior chamber angle assessment.
  Journal of glaucoma 2009 Wang D, Pekmezci M, Basham RP, He M, Seider MI, Lin SC
• Anterior segment optical coherence tomography as a screening tool for the assessment of the anterior segment angle.
  Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 2009 Pekmezci M, Porco TC, Lin SC
• The characteristics of glaucoma in Japanese Americans.
  Archives of ophthalmology (Chicago, Ill. : 1960) 2009 Pekmezci M, Vo B, Lim AK, Hirabayashi DR, Tanaka GH, Weinreb RN, Lin SC