Melanie Ott, MD, PhD
Professor
Medicine
School of Medicine

All are important public health problems and with HCV and HIV sharing common traits including high propensities to establish chronic infections and a lack of efficient vaccines, and Zika and SARS-CoV-2 causing global pandemics leading to death and disability. In recent years, we have established four main technologies to study these viruses—rapid quantitative tests, human organoids, a viral protein library and transcriptomics and chromatin biology. We recently applied these technologies to the studies of SARS-CoV-2, leading to the development of a new direct detection CRISPR diagnostic and the identification of shared host factors necessary for the replication of SARS-CoV-2 and common cold coronaviruses. SARS-CoV-2, HCV and HIV research in my laboratory includes replication studies with infectious viral clones, which are performed in the BSL3 laboratory. Recent rotation projects in the lab:

• characterizing influenza B infection in human airway organoids
• developing a new hepatitis B clone to screen for host factors regulating cccDNA formation

• Assembly reactions of SARS-CoV-2 nucleocapsid protein with nucleic acid.
  bioRxiv : the preprint server for biology 2023 Zhao H, Syed AM, Khalid MM, Nguyen A, Ciling A, Wu D, Yau WM, Srinivasan S, Esposito D, Doudna JA, Piszczek G, Ott M, Schuck P
• Protocol for an in vitro assay to study HIV-1 Tat methylation.
  STAR protocols 2023 Boehm D, Kaehlcke K, Schnoelzer M, Ott M
• A flow cytometry-based assay to investigate HIV-1 expression in SMYD5 shRNA containing primary CD4+ T cells.
  STAR protocols 2023 Boehm D, Ott M
• Hepatitis C virus infects and perturbs liver stem cells.
  mBio 2023 Meyers NL, Ashuach T, Lyons DE, Khalid MM, Simoneau CR, Erickson AL, Bouhaddou M, Nguyen TT, Kumar GR, Taha TY, Natarajan V, Baron JL, Neff N, Zanini F, Mahmoudi T, Quake SR, Krogan NJ, Cooper S, …
• Previous exposure to Spike-providing parental strains confers neutralizing immunity to XBB lineage and other SARS-CoV-2 recombinants in the context of vaccination.
  Emerging microbes & infections 2023 Suryawanshi RK, Taha TY, McCavitt-Malvido M, Silva I, Khalid MM, Syed AM, Chen IP, Saldhi P, Sreekumar B, Montano M, Foresythe K, Tabata T, Kumar GR, Sotomayor-Gonzalez A, Servellita V, Gliwa A, …
• Colloidal aggregation confounds cell-based Covid-19 antiviral screens.
  bioRxiv : the preprint server for biology 2023 Glenn IS, Hall LN, Khalid MM, Ott M, Shoichet BK
• HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing.
  Viruses 2023 Lyons DE, Kumar P, Roan NR, Defechereux PA, Feschotte C, Lange UC, Murthy N, Sameshima P, Verdin E, Ake JA, Parsons MS, Nath A, Gianella S, Smith DM, Kallas EG, Villa TJ, Strange R, Mwesigwa B, Furler…
• Post-acute immunological and behavioral sequelae in mice after Omicron infection.
  bioRxiv : the preprint server for biology 2023 Ma T, Suryawanshi RK, Miller SR, Ly KK, Thomas R, Elphick N, Yin K, Luo X, Kaliss N, Chen IP, Montano M, Sreekumar B, Standker L, Münch J, Heath Damron F, Palop JJ, Ott M, Roan NR
• Comprehensive synergy mapping links a BAF- and NSL-containing "supercomplex" to the transcriptional silencing of HIV-1.
  Cell reports 2023 Li Z, Deeks SG, Ott M, Greene WC
• A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo.
  PLoS pathogens 2023 Taha TY, Suryawanshi RK, Chen IP, Correy GJ, McCavitt-Malvido M, O'Leary PC, Jogalekar MP, Diolaiti ME, Kimmerly GR, Tsou CL, Gascon R, Montano M, Martinez-Sobrido L, Krogan NJ, Ashworth A, Fraser JS,…
• SARS-CoV-2 protein ORF8 limits expression levels of Spike antigen and facilitates immune evasion of infected host cells.
  The Journal of biological chemistry 2023 Kim IJ, Lee YH, Khalid MM, Chen IP, Zhang Y, Ott M, Verdin E
• Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication.
  RSC advances 2023 Bajaj T, Wehri E, Suryawanshi RK, King E, Pardeshi KS, Behrouzi K, Khodabakhshi Z, Schulze-Gahmen U, Kumar GR, Mofrad MRK, Nomura DK, Ott M, Schaletzky J, Murthy N
• Mild SARS-CoV-2 infection results in long-lasting microbiota instability.
  mBio 2023 Upadhyay V, Suryawanshi RK, Tasoff P, McCavitt-Malvido M, Kumar RG, Murray VW, Noecker C, Bisanz JE, Hswen Y, Ha CWY, Sreekumar B, Chen IP, Lynch SV, Ott M, Lee S, Turnbaugh PJ
• Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase.
  Journal of medicinal chemistry 2023 Singh I, Li F, Fink EA, Chau I, Li A, Rodriguez-Hernández A, Glenn I, Zapatero-Belinchón FJ, Rodriguez ML, Devkota K, Deng Z, White K, Wan X, Tolmachova NA, Moroz YS, Kaniskan HÜ, Ott M, García-Sastre…
• A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo.
  bioRxiv : the preprint server for biology 2023 Taha TY, Suryawanshi RK, Chen IP, Correy GJ, O'Leary PC, Jogalekar MP, McCavitt-Malvido M, Diolaiti ME, Kimmerly GR, Tsou CL, Martinez-Sobrido L, Krogan NJ, Ashworth A, Fraser JS, Ott M
• Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6.
  Nature communications 2023 Taha TY, Chen IP, Hayashi JM, Tabata T, Walcott K, Kimmerly GR, Syed AM, Ciling A, Suryawanshi RK, Martin HS, Bach BH, Tsou CL, Montano M, Khalid MM, Sreekumar BK, Renuka Kumar G, Wyman S, Doudna JA, …
• A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication.
  RSC advances 2023 Han H, Gracia AV, Røise JJ, Boike L, Leon K, Schulze-Gahmen U, Stentzel MR, Bajaj T, Chen D, Li IC, He M, Behrouzi K, Khodabakhshi Z, Nomura DK, Mofrad MRK, Kumar GR, Ott M, Murthy N
• The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11.
  Cell reports 2023 Boehm D, Lam V, Schnolzer M, Ott M
• SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.
  Stem cell reports 2023 Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, …
• Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6.
  bioRxiv : the preprint server for biology 2023 Taha TY, Chen IP, Hayashi JM, Tabata T, Walcott K, Kimmerly GR, Syed AM, Ciling A, Suryawanshi RK, Martin HS, Bach BH, Tsou CL, Montano M, Khalid MM, Sreekumar BK, Kumar GR, Wyman S, Doudna JA, Ott M
• Nuclear accumulation of host transcripts during Zika Virus Infection.
  PLoS pathogens 2023 Leon KE, Khalid MM, Flynn RA, Fontaine KA, Nguyen TT, Kumar GR, Simoneau CR, Tomar S, Jimenez-Morales D, Dunlap M, Kaye J, Shah PS, Finkbeiner S, Krogan NJ, Bertozzi C, Carette JE, Ott M
• Mild SARS-CoV-2 infection results in long-lasting microbiota instability.
  bioRxiv : the preprint server for biology 2022 Upadhyay V, Suryawanshi R, Tasoff P, McCavitt-Malvido M, Kumar GR, Murray VW, Noecker C, Bisanz JE, Hswen Y, Ha C, Sreekumar B, Chen IP, Lynch SV, Ott M, Lee S, Turnbaugh PJ
• Neutralizing Immunity Induced Against the Omicron BA.1 and BA.2 Variants in Vaccine Breakthrough Infections.
  The Journal of infectious diseases 2022 Brazer N, Morris MK, Servellita V, Anglin K, Saldhi P, Garcia-Knight M, Bethancourt S, Sotomayor-Gonzalez A, Wang B, Foresythe A, Nguyen J, Gliwa AS, Pineda-Ramirez J, Sanchez RD, Zhang Y, Ott M, …
• Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons.
  mBio 2022 Kong W, Montano M, Corley MJ, Helmy E, Kobayashi H, Kinisu M, Suryawanshi R, Luo X, Royer LA, Roan NR, Ott M, Ndhlovu LC, Greene WC
• Viral Hijacking of BET Proteins.
  Viruses 2022 Chen IP, Ott M
• SARS-CoV-2 hybrid immunity: silver bullet or silver lining?
  Nature reviews. Immunology 2022 Suryawanshi R, Ott M
• SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.
  PLoS pathogens 2022 Walter M, Chen IP, Vallejo-Gracia A, Kim IJ, Bielska O, Lam VL, Hayashi JM, Cruz A, Shah S, Soveg FW, Gross JD, Krogan NJ, Jerome KR, Schilling B, Ott M, Verdin E
• Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3.
  Nature communications 2022 Peters CE, Schulze-Gahmen U, Eckhardt M, Jang GM, Xu J, Pulido EH, Bardine C, Craik CS, Ott M, Gozani O, Verba KA, Hüttenhain R, Carette JE, Krogan NJ
• Catching BETs by viruses.
  Biochimica et biophysica acta. Gene regulatory mechanisms 2022 Zandian M, Chen IP, Byrareddy SN, Fujimori DG, Ott M, Kutateladze TG
• NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.
  bioRxiv : the preprint server for biology 2022 Simoneau CR, Chen PY, Xing GK, Khalid MM, Meyers NL, Hayashi JM, Taha TY, Leon KE, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose J, Matthay…
• Taking cues from convalescence to improve vaccines against hepatitis C virus.
  The Journal of clinical investigation 2022 Sreekumar BK, Taha TY, Ott M
• A Single-Component Luminescent Biosensor for the SARS-CoV-2 Spike Protein.
  Journal of the American Chemical Society 2022 Ravalin M, Roh H, Suryawanshi R, Kumar GR, Pak JE, Ott M, Ting AY
• Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Syed AM, Ciling A, Taha TY, Chen IP, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Suryawanshi R, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Spraggon L, Tabata T, Ott …
• Accelerating PERx reaction enables covalent nanobodies for potent neutralization of SARS-CoV-2 and variants.
  Chem 2022 Yu B, Li S, Tabata T, Wang N, Cao L, Kumar GR, Sun W, Liu J, Ott M, Wang L
• Tropism of SARS-CoV-2 for human cortical astrocytes.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Ross J, Parikshak N, Wang S, Zhou L, Koontz M, Velmeshev D, Siebert CV, Gemenes KM, Tabata T, Perez Y, Wang L, Mostajo-Radji MA, de Majo M, Donohue KC, Shin…
• Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2.
  Cell reports 2022 Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Khalid MM, Taha TY, Tabata T, Hayashi JM, Soveg FW, Carlson-Stevermer J, Gupta M, Zhang MY, Lam VL, Li Y, Yu Z, Titus EW, Diallo A, Oki J, Holden K, …
• Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination.
  JCI insight 2022 Matsui Y, Li L, Prahl M, Cassidy AG, Ozarslan N, Golan Y, Gonzalez VJ, Lin CY, Jigmeddagva U, Chidboy MA, Montano M, Taha TY, Khalid MM, Sreekumar B, Hayashi JM, Chen PY, Kumar GR, Warrier L, Wu AH, …
• A single-component luminescent biosensor for the SARS-CoV-2 spike protein.
  bioRxiv : the preprint server for biology 2022 Ravalin M, Roh H, Suryawanshi R, Kumar GR, Pak J, Ott M, Ting AY
• Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination.
  Nature 2022 Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Gascon R, Tsou CL, Garcia-Knight MA, Sotomayor-Gonzalez A, …
• Immediate myeloid depot for SARS-CoV-2 in the human lung.
  Research square 2022 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, …
• Immediate myeloid depot for SARS-CoV-2 in the human lung.
  bioRxiv : the preprint server for biology 2022 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, …
• Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants.
  Cell 2022 Servellita V, Syed AM, Morris MK, Brazer N, Saldhi P, Garcia-Knight M, Sreekumar B, Khalid MM, Ciling A, Chen PY, Kumar GR, Gliwa AS, Nguyen J, Sotomayor-Gonzalez A, Zhang Y, Frias E, Prostko J, …
• Accelerating PERx Reaction Enables Covalent Nanobodies for Potent Neutralization of SARS-Cov-2 and Variants.
  bioRxiv : the preprint server for biology 2022 Yu B, Li S, Tabata T, Wang N, Kumar GR, Liu J, Ott MM, Wang L
• Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system.
  Open biology 2022 Natarajan V, Simoneau CR, Erickson AL, Meyers NL, Baron JL, Cooper S, McDevitt TC, Ott M
• Limited Cross-Variant Immunity after Infection with the SARS-CoV-2 Omicron Variant Without Vaccination.
  medRxiv : the preprint server for health sciences 2022 Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, …
• SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.
  bioRxiv : the preprint server for biology 2022 Walter M, Chen IP, Vallejo-Gracia A, Kim IJ, Bielska O, Lam VL, Hayashi JM, Cruz A, Shah S, Gross JD, Krogan NJ, Schilling B, Ott M, Verdin E
• Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles.
  medRxiv : the preprint server for health sciences 2022 Syed AM, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Spraggon L, Taha TY, Tabata T, Chen IP, Ott M, Doudna JA
• Viral E Protein Neutralizes BET Protein-Mediated Post-Entry Antagonism of SARS-CoV-2.
  bioRxiv : the preprint server for biology 2021 Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Carlson-Stevermer J, Gupta M, Zhang MY, Soveg FW, Hayashi JM, Taha TY, Lam VL, Li Y, Yu Z, Titus EW, Diallo A, Oki J, Holden K, QCRG Structural …
• Identification of a therapeutic interfering particle-A single-dose SARS-CoV-2 antiviral intervention with a high barrier to resistance.
  Cell 2021 Chaturvedi S, Vasen G, Pablo M, Chen X, Beutler N, Kumar A, Tanner E, Illouz S, Rahgoshay D, Burnett J, Holguin L, Chen PY, Ndjamen B, Ott M, Rodick R, Rogers T, Smith DM, Weinberger LS
• Rapid assessment of SARS-CoV-2-evolved variants using virus-like particles.
  Science (New York, N.Y.) 2021 Syed AM, Taha TY, Tabata T, Chen IP, Ciling A, Khalid MM, Sreekumar B, Chen PY, Hayashi JM, Soczek KM, Ott M, Doudna JA
• Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases.
  Nature chemical biology 2021 Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, Díaz de León Derby M, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, …
• Accelerated RNA detection using tandem CRISPR nucleases.
  Nature chemical biology 2021 Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, Díaz de León Derby M, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, …
• Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2.
  ACS infectious diseases 2021 Biering SB, Van Dis E, Wehri E, Yamashiro LH, Nguyenla X, Dugast-Darzacq C, Graham TGW, Stroumza JR, Golovkine GR, Roberts AW, Fines DM, Spradlin JN, Ward CC, Bajaj T, Dovala D, Schulze-Gamen U, Bajaj…
• Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19.
  Scientific reports 2021 Le BL, Andreoletti G, Oskotsky T, Vallejo-Gracia A, Rosales R, Yu K, Kosti I, Leon KE, Bunis DG, Li C, Kumar GR, White KM, García-Sastre A, Ott M, Sirota M
• SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.
  bioRxiv : the preprint server for biology 2021 Hysenaj L, Little S, Kulhanek K, Gbenedio OM, Rodriguez L, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Bahl K, Mick E, Li JZ, Ding VW, Matsumoto S, Maishan M, Simoneau C, Fragiadakis G, …
• Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein.
  bioRxiv : the preprint server for biology 2021 Weinberg ZY, Hilburger CE, Kim M, Cao L, Khalid M, Elmes S, Diwanji D, Hernandez E, Lopez J, Schaefer K, Smith AM, Zhou F, QCRG Structural Biology Consortium, Kumar GR, Ott M, Baker D, El-Samad H
• Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant.
  Cell 2021 Deng X, Garcia-Knight MA, Khalid MM, Servellita V, Wang C, Morris MK, Sotomayor-González A, Glasner DR, Reyes KR, Gliwa AS, Reddy NP, Sanchez San Martin C, Federman S, Cheng J, Balcerek J, Taylor J, …
• Novel RT-ddPCR assays for measuring the levels of subgenomic and genomic SARS-CoV-2 transcripts.
  Methods (San Diego, Calif.) 2021 Telwatte S, Martin HA, Marczak R, Fozouni P, Vallejo-Gracia A, Kumar GR, Murray V, Lee S, Ott M, Wong JK, Yukl SA
• Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19.
  Research square 2021 Le BL, Andreoletti G, Oskotsky T, Vallejo-Gracia A, Rosales R, Yu K, Kosti I, Leon KE, Bunis DG, Li C, Kumar GR, White KM, García-Sastre A, Ott M, Sirota M
• Accelerated RNA detection using tandem CRISPR nucleases.
  medRxiv : the preprint server for health sciences 2021 Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, de León Derby MD, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, Stephens SI…
• A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection.
  Cell reports 2021 Kulsuptrakul J, Wang R, Meyers NL, Ott M, Puschnik AS
• SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19.
  Science translational medicine 2021 Perez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Silva AC, Ramadoss GN, Flanigan WR, Fozouni P, Li H, Chen PY, Nakamura K, Whitman JD, Hanson PJ, McManus BM, Ott M, Conklin BR, McDevitt TC
• Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation.
  medRxiv : the preprint server for health sciences 2021 Deng X, Garcia-Knight MA, Khalid MM, Servellita V, Wang C, Morris MK, Sotomayor-González A, Glasner DR, Reyes KR, Gliwa AS, Reddy NP, Martin CSS, Federman S, Cheng J, Balcerek J, Taylor J, Streithorst…
• Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA.
  Journal of virological methods 2021 Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA
• Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo.
  Journal of virology 2021 Gramatica A, Schwarzer R, Brantley W, Varco-Merth B, Sperber HS, Hull PA, Montano M, Migueles SA, Rosenthal D, Hogan LE, Johnson JR, Packard TA, Grimmett ZW, Herzig E, Besnard E, Nekorchuk M, Hsiao F,…
• Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes.
  bioRxiv : the preprint server for biology 2021 Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Perez Y, Mostajo-Radji MA, Wang S, Velmeshev D, Salma J, Kumar GR, Pollen AA, Crouch EE, Ott M, Kriegstein AR
• Novel RT-ddPCR Assays for determining the transcriptional profile of SARS-CoV-2.
  bioRxiv : the preprint server for biology 2021 Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA
• Author Correction: Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
  Nature metabolism 2021 Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin …
• Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses.
  Cell 2020 Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano KA, Hayashi JM, Carlson-Stevermer J, Zengel JR, Richards CM, Fozouni P, Oki J, Rodriguez L, Joehnk B, Walcott K, Holden K, Sil A, Carette JE…
• Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy.
  Cell 2020 Fozouni P, Son S, Díaz de León Derby M, Knott GJ, Gray CN, D'Ambrosio MV, Zhao C, Switz NA, Kumar GR, Stephens SI, Boehm D, Tsou CL, Shu J, Bhuiya A, Armstrong M, Harris AR, Chen PY, Osterloh JM, …
• Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology.
  Cell stem cell 2020 Simoneau CR, Ott M
• Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.
  Cell stem cell 2020 Samuel RM, Majd H, Richter MN, Ghazizadeh Z, Zekavat SM, Navickas A, Ramirez JT, Asgharian H, Simoneau CR, Bonser LR, Koh KD, Garcia-Knight M, Tassetto M, Sunshine S, Farahvashi S, Kalantari A, Liu W,…
• Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
  Nature metabolism 2020 Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin …
• An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
  Science (New York, N.Y.) 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…
• Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
  Science (New York, N.Y.) 2020 Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor…
• SIRT1 is downregulated by autophagy in senescence and ageing.
  Nature cell biology 2020 Xu C, Wang L, Fozouni P, Evjen G, Chandra V, Jiang J, Lu C, Nicastri M, Bretz C, Winkler JD, Amaravadi R, Garcia BA, Adams PD, Ott M, Tong W, Johansen T, Dou Z, Berger SL
• Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses.
  bioRxiv : the preprint server for biology 2020 Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano K, Hayashi JM, Carlson-Stevermer J, Oki J, Holden K, Krogan NJ, Ott M, Puschnik AS
• SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients.
  bioRxiv : the preprint server for biology 2020 Pérez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Ramadoss GN, Silva AC, Flanigan WR, Li H, Nakamura K, Whitman JD, Ott M, Conklin BR, McDevitt TC
• Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo.
  Cell stem cell 2020 Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, Yuan J, de Haan S, Hemrika W, Rösch K,…
• An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation.
  bioRxiv : the preprint server for biology 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…
• Turning up the heat on HIV-1.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Chen IP, Ott M
• The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
  Cell 2020 Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, Richards AL, Stevenson E, Gordon DE, Rojc A, Obernier K, Fabius JM, Soucheray…
• An 'Arms Race' between the Nonsense-mediated mRNA Decay Pathway and Viral Infections.
  Seminars in cell & developmental biology 2020 Leon K, Ott M
• A combinatorial view of old and new RNA polymerase II modifications.
  Transcription 2020 Lyons DE, McMahon S, Ott M
• A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
  Nature 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, …
• Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract.
  Nature communications 2019 Khan S, Lew I, Wu F, Fritts L, Fontaine KA, Tomar S, Trapecar M, Shehata HM, Ott M, Miller CJ, Sanjabi S
• Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.
  Molecular cell 2019 Ali I, Ruiz DG, Ni Z, Johnson JR, Zhang H, Li PC, Khalid MM, Conrad RJ, Guo X, Min J, Greenblatt J, Jacobson M, Krogan NJ, Ott M
• High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets.
  Methods in molecular biology (Clifton, N.J.) 2019 Schilling B, Meyer JG, Wei L, Ott M, Verdin E
• A BAF'ling Approach to Curing HIV.
  Cell chemical biology 2018 Tomar S, Ali I, Ott M
• How cells hush a viral invader.
  Nature 2018 Fozouni P, Ott M
• Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.
  Chemical reviews 2018 Ali I, Conrad RJ, Verdin E, Ott M
• Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1.
  The Journal of experimental medicine 2017 Jeng MY, Hull PA, Fei M, Kwon HS, Tsou CL, Kasler H, Ng CP, Gordon DE, Johnson J, Krogan N, Verdin E, Ott M
• Host Methyltransferases and Demethylases: Potential New Epigenetic Targets for HIV Cure Strategies and Beyond.
  AIDS research and human retroviruses 2017 Boehm D, Ott M
• The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes.
  Molecular cell 2017 Conrad RJ, Fozouni P, Thomas S, Sy H, Zhang Q, Zhou MM, Ott M
• Flow Cytometric Analysis of HIV-1 Transcriptional Activity in Response to shRNA Knockdown in A2 and A72 J-Lat Cell Lines.
  Bio-protocol 2017 Boehm D, Ott M
• Flow Cytometric Analysis of Drug-induced HIV-1 Transcriptional Activity in A2 and A72 J-Lat Cell Lines.
  Bio-protocol 2017 Boehm D, Ott M
• SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.
  Cell host & microbe 2017 Boehm D, Jeng M, Camus G, Gramatica A, Schwarzer R, Johnson JR, Hull PA, Montano M, Sakane N, Pagans S, Godin R, Deeks SG, Krogan NJ, Greene WC, Ott M
• Retrovirus Integration: Some Assembly Required?
  Cell host & microbe 2016 Ali I, Conrad RJ, Ott M
• The mTOR Complex Controls HIV Latency.
  Cell host & microbe 2016 Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman …
• Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication.
  The Journal of experimental medicine 2016 Khan S, Woodruff EM, Trapecar M, Fontaine KA, Ezaki A, Borbet TC, Ott M, Sanjabi S
• Asna1/TRC40 that mediates membrane insertion of tail-anchored proteins is required for efficient release of Herpes simplex virus 1 virions.
  Virology journal 2016 Ott M, Marques D, Funk C, Bailer SM
• International AIDS Society global scientific strategy: towards an HIV cure 2016.
  Nature medicine 2016 Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, International AIDS…
• Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity.
  eLife 2016 Shirakawa K, Wang L, Man N, Maksimoska J, Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E
• Entangled in a membranous web: ER and lipid droplet reorganization during hepatitis C virus infection.
  Current opinion in cell biology 2016 Meyers NL, Fontaine KA, Kumar GR, Ott M
• The HIV-1 Tat Protein Is Monomethylated at Lysine 71 by the Lysine Methyltransferase KMT7.
  The Journal of biological chemistry 2016 Ali I, Ramage H, Boehm D, Dirk LM, Sakane N, Hanada K, Pagans S, Kaehlcke K, Aull K, Weinberger L, Trievel R, Schnoelzer M, Kamada M, Houtz R, Ott M
• Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses.
  ACS chemical biology 2016 Conrad RJ, Ott M
• Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures.
  Molecular nutrition & food research 2015 Rosenkranz E, Metz CH, Maywald M, Hilgers RD, Weßels I, Senff T, Haase H, Jäger M, Ott M, Aspinall R, Plümäkers B, Rink L
• Subcellular trafficking and functional importance of herpes simplex virus type 1 glycoprotein M domains.
  The Journal of general virology 2015 Striebinger H, Zhang J, Ott M, Funk C, Radtke K, Duron J, Ruzsics Z, Haas J, Lippé R, Bailer SM
• Manipulation of the host protein acetylation network by human immunodeficiency virus type 1.
  Critical reviews in biochemistry and molecular biology 2015 Jeng MY, Ali I, Ott M
• The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain.
  PLoS pathogens 2015 Funk C, Ott M, Raschbichler V, Nagel CH, Binz A, Sodeik B, Bauerfeind R, Bailer SM
• SIRT1 deacetylates RORγt and enhances Th17 cell generation.
  The Journal of experimental medicine 2015 Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E
• SIRT1 deacetylates RORγt and enhances Th17 cell generation.
  The Journal of experimental medicine 2015 Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E
• Membrane Flotation Assay.
  Bio-protocol 2015 Vogt DA, Ott M
• Evolution of lysine acetylation in the RNA polymerase II C-terminal domain.
  BMC evolutionary biology 2015 Simonti CN, Pollard KS, Schröder S, He D, Bruneau BG, Ott M, Capra JA
• A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay.
  Molecular cell 2015 Ramage HR, Kumar GR, Verschueren E, Johnson JR, Von Dollen J, Johnson T, Newton B, Shah P, Horner J, Krogan NJ, Ott M
• 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond.
  Nature reviews. Molecular cell biology 2014 Verdin E, Ott M
• The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets.
  The Journal of biological chemistry 2014 Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M
• Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells.
  Molecular cell 2013 Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M
• Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus.
  Journal of virology 2013 Webster B, Ott M, Greene WC
• Acetylphosphate: a novel link between lysine acetylation and intermediary metabolism in bacteria.
  Molecular cell 2013 Verdin E, Ott M
• Bromodomain proteins in HIV infection.
  Viruses 2013 Boehm D, Conrad RJ, Ott M
• Three rules for HIV latency: location, location, and location.
  Cell host & microbe 2013 Ott M, Verdin E
• How the antiviral immune response boosts liver fat.
  Nature medicine 2013 Camus G, Ott M
• Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein.
  PLoS pathogens 2013 Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M
• Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core.
  The Journal of biological chemistry 2013 Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Ott M
• Snapshots: chromatin control of viral infection.
  Virology 2013 Knipe DM, Lieberman PM, Jung JU, McBride AA, Morris KV, Ott M, Margolis D, Nieto A, Nevels M, Parks RJ, Kristie TM
• Lipid droplets and viral infections.
  Methods in cell biology 2013 Camus G, Vogt DA, Kondratowicz AS, Ott M
• Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis.
  Journal of virology 2012 Webster B, Wissing S, Herker E, Ott M, Greene WC
• Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells.
  Journal of immunology (Baltimore, Md. : 1950) 2012 Kwon HS, Lim HW, Wu J, Schnölzer M, Verdin E, Ott M
• BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.
  Cell cycle (Georgetown, Tex.) 2012 Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li PC, Planelles V, Bradner JE, Zhou MM, Siliciano RF, Weinberger L, Verdin E, Ott M
• The control of HIV transcription: keeping RNA polymerase II on track.
  Cell host & microbe 2011 Ott M, Geyer M, Zhou Q
• Emerging role of lipid droplets in host/pathogen interactions.
  The Journal of biological chemistry 2011 Herker E, Ott M
• Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.
  The Journal of biological chemistry 2011 Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M
• Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis.
  The Journal of biological chemistry 2011 Harris C, Herker E, Farese RV, Ott M
• Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1).
  PLoS pathogens 2011 Sakane N, Kwon HS, Pagans S, Kaehlcke K, Mizusawa Y, Kamada M, Lassen KG, Chan J, Greene WC, Schnoelzer M, Ott M
• Functional characterization of the essential tail anchor of the herpes simplex virus type 1 nuclear egress protein pUL34.
  The Journal of general virology 2011 Ott M, Tascher G, Haßdenteufel S, Zimmermann R, Haas J, Bailer SM
• Unique ties between hepatitis C virus replication and intracellular lipids.
  Trends in endocrinology and metabolism: TEM 2011 Herker E, Ott M
• HIV never ceases to surprise: Innovative methods in the quest for a cure.
  Methods (San Diego, Calif.) 2011 Ott M
• Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1.
  Nature medicine 2010 Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV, Ott M
• Acetylation of tau inhibits its degradation and contributes to tauopathy.
  Neuron 2010 Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L
• Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies.
  Methods (San Diego, Calif.) 2010 Pagans S, Sakane N, Schnölzer M, Ott M
• CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation.
  Cell cycle (Georgetown, Tex.) 2010 Cho S, Schroeder S, Ott M
• HAT trick: p300, small molecule, inhibitor.
  Chemistry & biology 2010 Ott M, Verdin E
• The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription.
  Cell host & microbe 2010 Pagans S, Kauder SE, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel RC, Verdin E, Schnolzer M, Ott M
• Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells.
  The EMBO journal 2009 Cho S, Schroeder S, Kaehlcke K, Kwon HS, Pedal A, Herker E, Schnoelzer M, Ott M
• Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR.
  The Journal of pharmacology and experimental therapeutics 2009 Ott M, Fricker G, Bauer B
• Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Nakamura K, Nemani VM, Wallender EK, Kaehlcke K, Ott M, Edwards RH
• The ups and downs of SIRT1.
  Trends in biochemical sciences 2008 Kwon HS, Ott M
• Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation.
  Cell host & microbe 2008 Kwon HS, Brent MM, Getachew R, Jayakumar P, Chen LF, Schnolzer M, McBurney MW, Marmorstein R, Greene WC, Ott M
• Recruitment and activation of RSK2 by HIV-1 Tat.
  PloS one 2007 Hetzer C, Bisgrove D, Cohen MS, Pedal A, Kaehlcke K, Speyerer A, Bartscherer K, Taunton J, Ott M
• Hepatitis C and risk of lymphoma: results of the European multicenter case-control study EPILYMPH.
  Gastroenterology 2006 Nieters A, Kallinowski B, Brennan P, Ott M, Maynadié M, Benavente Y, Foretova L, Cocco PL, Staines A, Vornanen M, Whitby D, Boffetta P, Becker N, De Sanjosé S
• The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter.
  The Journal of biological chemistry 2006 Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M, Verdin E
• Analysis of p300 acetyltransferase substrate specificity by MALDI TOF mass spectrometry.
  Methods (San Diego, Calif.) 2005 Dormeyer W, Ott M, Schnölzer M
• Decoding Tat: the biology of HIV Tat posttranslational modifications.
  Microbes and infection 2005 Hetzer C, Dormeyer W, Schnölzer M, Ott M
• Probing lysine acetylation in proteins: strategies, limitations, and pitfalls of in vitro acetyltransferase assays.
  Molecular & cellular proteomics : MCP 2005 Dormeyer W, Ott M, Schnölzer M
• SIRT1 regulates HIV transcription via Tat deacetylation.
  PLoS biology 2005 Pagans S, Pedal A, North BJ, Kaehlcke K, Marshall BL, Dorr A, Hetzer-Egger C, Henklein P, Frye R, McBurney MW, Hruby H, Jung M, Verdin E, Ott M
• Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif.
  Journal of virology 2004 Schwer B, Ren S, Pietschmann T, Kartenbeck J, Kaehlcke K, Bartenschlager R, Yen TS, Ott M
• HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane.
  Molecular cell 2004 Witte V, Laffert B, Rosorius O, Lischka P, Blume K, Galler G, Stilper A, Willbold D, D'Aloja P, Sixt M, Kolanus J, Ott M, Kolanus W, Schuler G, Baur AS
• Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation.
  Novartis Foundation symposium 2004 Ott M, Dorr A, Hetzer-Egger C, Kaehlcke K, Schnolzer M, Henklein P, Cole P, Zhou MM, Verdin E
• Acetylation of the HIV-1 Tat protein: an in vitro study.
  Analytical and bioanalytical chemistry 2003 Dormeyer W, Dorr A, Ott M, Schnölzer M
• Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation.
  Molecular cell 2003 Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V, Henklein P, Schnoelzer M, Loret E, Cole PA, Verdin E, Ott M
• Release and intercellular transfer of cell surface CD81 via microparticles.
  Journal of immunology (Baltimore, Md. : 1950) 2002 Fritzsching B, Schwer B, Kartenbeck J, Pedal A, Horejsi V, Ott M
• The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase.
  The Journal of cell biology 2002 Schwer B, North BJ, Frye RA, Ott M, Verdin E
• Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain.
  The EMBO journal 2002 Dorr A, Kiermer V, Pedal A, Rackwitz HR, Henklein P, Schubert U, Zhou MM, Verdin E, Ott M
• Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain.
  Molecular cell 2002 Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, Ott M, Verdin E, Zhou MM