Mehrdad Matloubian, MD, PhD
Professor
Medicine
School of Medicine

I have a general interest in mechanisms of immune mediated diseases and approaches for a better understanding of the molecular bases of such processes. The goal is to provided therapeutic for treatment of autoimmune and inflammatory diseases through a better understanding of the involved pathways.

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California, San Francisco 2021
• Postdoctoral Studies Immunology University of California, San Francisco 2004
• Rheumatology Fellowship University of California, San Francisco 2001
• Internal Medicine University of California, San Francisco 1998
• MD/PhD Virology University of California, Los Angeles 1996

Websites

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• Profile at immunology.ucsf.edu (immunology.ucsf.edu)

Grants and Projects

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• Regulation of Lymphocyte Trafficking by S1P1 and CD69, NIH, 2008-2013
• Molecular and Cellular Regulation of Lymphocyte Exit by Interferon, NIH, 2007-2010

Publications (64)

Top publication keywords:
Lymphoid TissueReceptors, LysosphingolipidToll-Like Receptor 7CD8-Positive T-LymphocytesSpleenChemokines, CXCListeriosisToll-Like ReceptorsImmunologic MemoryReceptors, CXCR3DEAD-box RNA HelicasesLymphocytic choriomeningitis virusLymphocytic ChoriomeningitisChemokines, CCMembrane Glycoproteins

• Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report.
  Neurology(R) neuroimmunology & neuroinflammation 2023 Rolfes M, Harroud A, Zorn KC, Tubati A, Omura C, Kurtz K, Matloubian M, Berger A, Chiu CY, Wilson MR, Ramachandran PS
• Sleep Disturbance and SARS-CoV-2 Vaccinations in Patients With Chronic Inflammatory Disease.
  Arthritis care & research 2023 Pawar N, Taylor KE, Yang M, Deepak P, Kim W, Paley MA, Matloubian M, Carvidi A, Ciorba MA, Demissie E, El-Qunni A, Huang K, Kinnett B, McMorrow LE, Paez D, Poole M, Rose A, Schriefer RE, Kim AHJ, …
• A simple point-of-care assay accurately detects anti-spike antibodies after SARS-CoV-2 vaccination.
  Journal of clinical virology plus 2023 Greene SE, Huang Y, Kim W, Liebeskind MJ, Chandrasekaran V, Liu Z, Deepak P, Paley MA, Lew D, Yang M, Matloubian M, Gensler LS, Nakamura MC, O'Hallaran JA, Presti RM, Whelan SPJ, Buchser WJ, Kim AHJ, …
• Author Correction: Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.
  Nature communications 2022 Lee JV, Housley F, Yau C, Nakagawa R, Winkler J, Anttila JM, Munne PM, Savelius M, Houlahan KE, Van de Mark D, Hemmati G, Hernandez GA, Zhang Y, Samson S, Baas C, Kok M, Esserman LJ, van 't Veer LJ, …
• Reactogenicity of the Messenger RNA SARS-CoV-2 Vaccines Associated With Immunogenicity in Patients With Autoimmune and Inflammatory Disease.
  Arthritis care & research 2022 Yang MM, Taylor KE, Paez D, Carividi A, Demissie E, Pawar N, El-Qunni AA, McMorrow LE, Schriefer RE, Huang K, Kinnett B, Klebert M, Haile A, O'Halloran JA, Presti RM, Kim W, Ellebedy AH, Ciorba MA, …

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• Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.
  Nature communications 2022 Lee JV, Housley F, Yau C, Nakagawa R, Winkler J, Anttila JM, Munne PM, Savelius M, Houlahan KE, Van de Mark D, Hemmati G, Hernandez GA, Zhang Y, Samson S, Baas C, Kok M, Esserman LJ, van 't Veer LJ, …
• Su1481: IMPACT OF IMMUNOSUPPRESSIVE THERAPIES ON ANTIBODY DECAY FOLLOWING MRNA VACCINATION TO SARS-COV-2 IN A PROSPECTIVE COHORT OF PATIENTS WITH CHRONIC INFLAMMATORY DISEASES.
  Gastroenterology 2022 Parakkal Deepak, Wooseob Kim, Michael Paley, Monica Yang, Samantha Burdess, Alexander B. Carvidi, Emanuel Demissie, Alia A. El-Qunni, Alem Haile, Katherine Huang, Guadalupe Oliva Escudero, Lily E. …
• Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus.
  Science (New York, N.Y.) 2022 Perez RK, Gordon MG, Subramaniam M, Kim MC, Hartoularos GC, Targ S, Sun Y, Ogorodnikov A, Bueno R, Lu A, Thompson M, Rappoport N, Dahl A, Lanata CM, Matloubian M, Maliskova L, Kwek SS, Li T, Slyper M,…
• Combined Single Cell Transcriptome and Surface Epitope Profiling Identifies Potential Biomarkers of Psoriatic Arthritis and Facilitates Diagnosis via Machine Learning.
  Frontiers in immunology 2022 Liu J, Kumar S, Hong J, Huang ZM, Paez D, Castillo M, Calvo M, Chang HW, Cummins DD, Chung M, Yeroushalmi S, Bartholomew E, Hakimi M, Ye CJ, Bhutani T, Matloubian M, Gensler LS, Liao W
• ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8+ T Cell Effector and Memory Responses.
  Journal of immunology (Baltimore, Md. : 1950) 2022 Sin JH, Kashyap S, Acenas D, Cortez JT, Lee J, Marson A, Matloubian M, Waterfield MR
• Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2 : A Prospective Cohort Study.
  Annals of internal medicine 2021 Deepak P, Kim W, Paley MA, Yang M, Carvidi AB, Demissie EG, El-Qunni AA, Haile A, Huang K, Kinnett B, Liebeskind MJ, Liu Z, McMorrow LE, Paez D, Pawar N, Perantie DC, Schriefer RE, Sides SE, Thapa M, …
• POS1255 REACTOGENICITY OF SARS-COV-2 VACCINES IN PATIENTS WITH AUTOIMMUNE AND INFLAMMATORY DISEASE.
  Annals of the Rheumatic Diseases 2021 M. Yang, P. Katz, D. Paez, A. Carvidi, M. Matloubian, M. Nakamura, L. S. Gensler
• Glucocorticoids and B Cell Depleting Agents Substantially Impair Immunogenicity of mRNA Vaccines to SARS-CoV-2.
  medRxiv : the preprint server for health sciences 2021 Deepak P, Kim W, Paley MA, Yang M, Carvidi AB, El-Qunni AA, Haile A, Huang K, Kinnett B, Liebeskind MJ, Liu Z, McMorrow LE, Paez D, Perantie DC, Schriefer RE, Sides SE, Thapa M, Gergely M, Abushamma S…
• Abstract GS1-08: The MYC oncogene suppresses tumor immune infiltration and function which is reversible with combinatorial immunotherapies.
  Cancer Research 2021 Joyce V Lee, Filomena Housley, Christina Yau, Golzar Hemmati, Yibing Zhang, Susan Samson, Carole Baas, Hope Rugo, Mehrdad Matloubian, Andrei Goga
• A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands.
  Science signaling 2021 Shen L, Matloubian M, Kadlecek TA, Weiss A
• A phase Ib trial of the cyclin-dependent kinase inhibitor dinaciclib (dina) in combination with pembrolizumab (P) in patients with advanced triple-negative breast cancer (TNBC) and response correlation with MYC-overexpression.
  Journal of Clinical Oncology 2020 Amy Jo Chien, Amelia S Gliwa, Siti Rahmaputri, Heidi F Dittrich, Melanie Catherine Majure, Hope S. Rugo, Michelle E. Melisko, Pamela N. Munster, John W. Park, Mark M. Moasser, Mehrdad Matloubian, …
• The Molecular Medicine Investigation Unit: Linking Patient Care and Scientific Inquiry in Physician-Scientist Training.
  Journal of graduate medical education 2020 Berger A, Matloubian M, Shah NP, Wachter RM, DeRisi JL, Anderson M
• miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.
  Cell reports 2019 Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, …
• Perivascular Fibroblasts of the Developing Spleen Act as LTα1β2-Dependent Precursors of Both T and B Zone Organizer Cells.
  Cell reports 2017 Schaeuble K, Britschgi MR, Scarpellino L, Favre S, Xu Y, Koroleva E, Lissandrin TKA, Link A, Matloubian M, Ware CF, Nedospasov SA, Tumanov AV, Cyster JG, Luther SA
• Sex- and corticotropin-releasing factor receptor 2- dependent actions of urocortin 1 during inflammation.
  American journal of physiology. Regulatory, integrative and comparative physiology 2016 Hasdemir B, Mhaske P, Paruthiyil S, Garnett EA, Heyman MB, Matloubian M, Bhargava A
• Sex- and Corticotropin-releasing Factor Receptor 2-dependent Actions of Urocortin 1 During Colitis.
  The FASEB Journal 2016 Burcu Hasdemir, Mehrdad Matloubian, Elizabeth A Garnett, Melvin B Heyman, Aditi Bhargava
• Local antigen and inflammation in the lung induce the preferential establishment and maintenance of CXCR6 and CD49a-expressing antigen-specific CD8 TRM cells in the lung parenchyma and airways (MUC1P.900).
  The Journal of Immunology 2015 Sean McMaster, Jarad Wilson, Alex Wein, Paul Dunbar, Mehrdad Matloubian, Jacob Kohlmeier
• 522 Sex-Specific Responses of the Corticotropin-Releasing Factor System in a Mouse Model of Inflammatory Bowel Disease.
  Gastroenterology 2015 Burcu Hasdemir, Shilpi Mahajan, Mehrdad Matloubian, Aditi Bhargava
• Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Mueller J, Matloubian M, Zikherman J
• A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A
• 16 MIR-17~92 promotes T follicular helper cell differentiation and represses subset-inappropriate gene expression.
  Cytokine 2013 Dirk Baumjohann, Robin Kageyama, Jonathan M. Clingan, Malika M. Morar, Sana Patel, Dimitri de Kouchkovsky, Oliver Bannard, Jeffrey A. Bluestone, Mehrdad Matloubian, K Mark Ansel, Lukas T. Jeker
• 91 Homotypic T–T synapses promote collective CD8+ T cell differentiation through exchange of IFN gamma.
  Cytokine 2013 Audrey Gérard, Omar Khan, Peter Beemiller, Erin Oswald, Joyce Hu, Mehrdad Matloubian, Matthew F. Krummel
• The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.
  Nature immunology 2013 Baumjohann D, Kageyama R, Clingan JM, Morar MM, Patel S, de Kouchkovsky D, Bannard O, Bluestone JA, Matloubian M, Ansel KM, Jeker LT
• B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection.
  Journal of immunology (Baltimore, Md. : 1950) 2013 Clingan JM, Matloubian M
• IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.
  International immunology 2013 Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM
• MicroRNA function in NK-cell biology.
  Immunological reviews 2013 Beaulieu AM, Bezman NA, Lee JE, Matloubian M, Sun JC, Lanier LL
• Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells.
  Nature immunology 2013 Gérard A, Khan O, Beemiller P, Oswald E, Hu J, Matloubian M, Krummel MF
• Th1 cell induction in lymph nodes according to a red-blue chemokine map.
  Immunity 2012 Matloubian M, Cyster JG
• Differential roles for RIG-I-like receptors and nucleic acid-sensing TLR pathways in controlling a chronic viral infection.
  Journal of immunology (Baltimore, Md. : 1950) 2012 Clingan JM, Ostrow K, Hosiawa KA, Chen ZJ, Matloubian M
• MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells.
  Immunity 2011 Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD, Matloubian M, Blelloch R, Ansel KM
• Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Hu JK, Kagari T, Clingan JM, Matloubian M
• CXCR3 expression affects the balance of effector and memory CD8 T cell generation (46.6).
  The Journal of Immunology 2011 Joyce Hu, Takashi Kagari, Jonathan Clingan, Mehrdad Matloubian
• Type I Interferon produced by infected cells but not plasmacytoid dendritic cells is required for effective CD8 T cell responses and clearance of a viral infection (105.37).
  The Journal of Immunology 2011 Jonathan Clingan, Kristin Ostrow, Karoline Hosiawa-Meagher, Zhijian Chen, Richard Locksley, Mehrdad Matloubian
• Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Beinke S, Phee H, Clingan JM, Schlessinger J, Matloubian M, Weiss A
• NK1.1+ cells are required for neutrophil recruitment to sites of early viral infection (43.4).
  The Journal of Immunology 2009 Karoline A. Hosiawa-Meagher, Jon Clingan, Mehrdad Matloubian
• The tyrosine kinase PYK2 integrates TCR and LFA-1 signaling in CD8 T cells to promote effector versus memory fate (83.21).
  The Journal of Immunology 2009 Soren Beinke, Mehrdad Matloubian, Joseph Schlessinger, Arthur Weiss
• S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress.
  Immunity 2007 Pham TH, Okada T, Matloubian M, Lo CG, Cyster JG
• Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Mueller SN, Matloubian M, Clemens DM, Sharpe AH, Freeman GJ, Gangappa S, Larsen CP, Ahmed R
• Regulation of homeostatic chemokine expression and cell trafficking during immune responses.
  Science (New York, N.Y.) 2007 Mueller SN, Hosiawa-Meagher KA, Konieczny BT, Sullivan BM, Bachmann MF, Locksley RM, Ahmed R, Matloubian M
• CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
  Nature 2006 Shiow LR, Rosen DB, Brdicková N, Xu Y, An J, Lanier LL, Cyster JG, Matloubian M
• Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients.
  Science (New York, N.Y.) 2005 Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, Cyster JG
• Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.
  Nature immunology 2004 Cinamon G, Matloubian M, Lesneski MJ, Xu Y, Low C, Lu T, Proia RL, Cyster JG
• Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.
  Nature 2004 Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG
• Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis.
  Journal of immunology (Baltimore, Md. : 1950) 2002 Luther SA, Bidgol A, Hargreaves DC, Schmidt A, Xu Y, Paniyadi J, Matloubian M, Cyster JG
• A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.
  Nature immunology 2000 Matloubian M, David A, Engel S, Ryan JE, Cyster JG
• A role for perforin in downregulating T-cell responses during chronic viral infection.
  Journal of virology 1999 Matloubian M, Suresh M, Glass A, Galvan M, Chow K, Whitmire JK, Walsh CM, Clark WR, Ahmed R
• Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.
  Journal of immunology (Baltimore, Md. : 1950) 1996 van der Most RG, Sette A, Oseroff C, Alexander J, Murali-Krishna K, Lau LL, Southwood S, Sidney J, Chesnut RW, Matloubian M, Ahmed R
• Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes.
  Journal of virology 1996 Slifka MK, Shen H, Matloubian M, Jensen ER, Miller JF, Ahmed R
• Mechanisms of CTL-mediated cytoxicity.
  Seminars in Virology 1996 William R. Clark, Craig M. Walsh, Mehrdad Matloubian, Alison A. Glass, Fumitaka Hayashi
• Molecular pathways of CTL-mediated cytotoxicity.
  Immunological reviews 1995 Clark WR, Walsh CM, Glass AA, Hayashi F, Matloubian M, Ahmed R
• Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity.
  Proceedings of the National Academy of Sciences of the United States of America 1995 Shen H, Slifka MK, Matloubian M, Jensen ER, Ahmed R, Miller JF
• Bone marrow is a major site of long-term antibody production after acute viral infection.
  Journal of virology 1995 Slifka MK, Matloubian M, Ahmed R
• Cell-mediated cytotoxicity in perforin-less mice.
  International reviews of immunology 1995 Clark WR, Walsh CM, Glass AA, Huang MT, Ahmed R, Matloubian M
• CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection.
  Journal of virology 1994 Matloubian M, Concepcion RJ, Ahmed R
• Immune function in mice lacking the perforin gene.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Walsh CM, Matloubian M, Liu CC, Ueda R, Kurahara CG, Christensen JL, Huang MT, Young JD, Ahmed R, Clark WR
• Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus.
  Journal of virology 1993 Matloubian M, Kolhekar SR, Somasundaram T, Ahmed R
• Molecular basis of organ-specific selection of viral variants during chronic infection.
  Journal of virology 1991 Ahmed R, Hahn CS, Somasundaram T, Villarete L, Matloubian M, Strauss JH
• Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice.
  The Journal of experimental medicine 1990 Matloubian M, Somasundaram T, Kolhekar SR, Selvakumar R, Ahmed R
• Genetic analysis of in vivo-selected viral variants causing chronic infection: importance of mutation in the L RNA segment of lymphocytic choriomeningitis virus.
  Journal of virology 1988 Ahmed R, Simon RS, Matloubian M, Kolhekar SR, Southern PJ, Freedman DM