Meghna Gupta, PhD
Specialist
Biochemistry and Biophysics
School of Medicine

Awards

Show all (3) Hide

• NIH K99/R00 Pathway to Independence, National Institute on Aging, 2022-2024
• Leading Edge Fellow, Leading Edge Program, 2022
• AHA postdoctoral fellowship, American Heart Association, 2021-2022

Education & Training

Show all (5) Hide

• Specialist Structural Biology University of California San Francisco 01/2024
• Postdoc Structural Biology University of California San Francisco 07/2021
• PhD Biochemistry and Biophysics Jawaharlal Nehru University 02/2016
• MSc Biochemistry and Biophysics Jawaharlal Nehru University 07/2010
• BSc Life Sciences University of Delhi 07/2008

Interests

Show all (5) Hide

• Membrane proteins
• CryoEM
• X-ray crystallography
• ABC transporters
• Fatty-acid metabolism

Websites

Show all (7) Hide

• @@MeghnaG27 on Twitter (twitter.com)
• Orcid (orcid.org)
• Google Scholar (scholar.google.com)
• ASBMB Women in BMB (asbmb.org)
• LinkedIn (linkedin.com)
• Leading Edge Fellow 2022 (leadingedgesymposium.org)
• ResearchGate (researchgate.net)

Publications (19)

Top publication keywords:
Nephrotic SyndromeDNA HelicasesSevere Acute Respiratory SyndromeFungal ProteinsArteriosclerosisBasidiomycotaOsteochondrodysplasiasAzolesAdenosine TriphosphatePhosphate Transport ProteinsImmunologic Deficiency SyndromesCandida albicansAntifungal AgentsPulmonary EmbolismDrug Resistance, Fungal

• Recent advances in Infectious Disease Research Using Cryo-Electron Tomography
  Frontiers in Molecular Biosciences 2024 Daniel Asarnow, Vada Allison Becker, Daija Bobe, Charlie Dubbledam, Jake D. Johnston, Mykhailo Kopylov, Nathalie Rose Lavoie, Qiuye Li, Jacob Michael Mattingly, Joshua H. Mendez, Mohammadreza Paraan, Jack Turner, Viraj Upadhye, Richard M. Walsh Jr., Meghna Gupta and Edward T. Eng
• Structural basis of prostaglandin efflux by MRP4.
  Nature structural & molecular biology 2024 Pourmal S, Green E, Bajaj R, Chemmama IE, Knudsen GM, Gupta M, Sali A, Cheng Y, Craik CS, Kroetz DL, Stroud RM
• Smart data collection for CryoEM
  Journal of Structural Biology 2022 Bepler, T. Borst, A. J. Bouvette, J. Cannone, G. Chen, S. Cheng, A. Cheng, A. Fan, Q. Grollios, F. Gupta, H. Gupta, M. Humphreys, T. Kim, P. T. Kuang, H. Li, Y. Noble, A. J. Punjani, A. Rice, W. J. Sorzano, C. O. S. Stagg, S. M. Strauss, J. Yu, L. Carragher, B. Potter, C. S.
• Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2.
  Cell reports 2022 Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Khalid MM, Taha TY, Tabata T, Hayashi JM, Soveg FW, Carlson-Stevermer J, Gupta M, Zhang MY, Lam VL, Li Y, Yu Z, Titus EW, Diallo A, Oki J, Holden K, …
• Molecular basis of multistep voltage activation in plant two-pore channel 1.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Dickinson MS, Lu J, Gupta M, Marten I, Hedrich R, Stroud RM

Show all (14 more) Hide

• Symmetry reduction in a hyperpolarization-activated homotetrameric ion channel
  bioRxiv 2021 Miles Sasha Dickinson, Meghna Gupta, Sergei A Pourmal, Maxine Bi, Robert M Stroud
• RTT109 and Fun30 proteins mediate epigenetic regulation of the DNA damage response pathway in C. albicans
  bioRxiv 2021 Pramita Garai, Prashant Kumar Maurya, Himanshu Bhatt, Aarti Goyal, Sakshi Dewasthale, Meghna Gupta, Dominic Thangminlen Haokip, Rohini Muthuswami
• Key computational findings reveal proton transfer as driving the functional cycle in the phosphate transporter PiPT.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Liu Y, Li C, Gupta M, Verma N, Johri AK, Stroud RM, Voth GA
• CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
  bioRxiv : the preprint server for biology 2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, …
• Highlighting membrane protein structure and function: A celebration of the Protein Data Bank.
  The Journal of biological chemistry 2021 Li F, Egea PF, Vecchio AJ, Asial I, Gupta M, Paulino J, Bajaj R, Dickinson MS, Ferguson-Miller S, Monk BC, Stroud RM
• An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
  Science 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…
• An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
  Science (New York, N.Y.) 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…
• Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
  Science (New York, N.Y.) 2020 Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor…
• An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation.
  bioRxiv : the preprint server for biology 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…
• Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.
  eLife 2019 Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P
• Vacuolar Sequestration of Azoles, a Novel Strategy of Azole Antifungal Resistance Conserved across Pathogenic and Nonpathogenic Yeast.
  Antimicrobial agents and chemotherapy 2019 Khandelwal NK, Wasi M, Nair R, Gupta M, Kumar M, Mondal AK, Gaur NA, Prasad R
• Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling.
  The Journal of biological chemistry 2017 Khandelwal NK, Chauhan N, Sarkar P, Esquivel BD, Coccetti P, Singh A, Coste AT, Gupta M, Sanglard D, White TC, Chauvel M, d'Enfert C, Chattopadhyay A, Gaur NA, Mondal AK, Prasad R
• Ligand-induced conformation changes drive ATP hydrolysis and function in SMARCAL1.
  The FEBS journal 2015 Gupta M, Mazumder M, Dhatchinamoorthy K, Nongkhlaw M, Haokip DT, Gourinath S, Komath SS, Muthuswami R
• Motifs Q and I are required for ATP hydrolysis but not for ATP binding in SWI2/SNF2 proteins.
  Biochemistry 2012 Nongkhlaw M, Gupta M, Komath SS, Muthuswami R