Meenal Sinha, PhD
Associate Researcher
Laboratory Medicine
School of Medicine

Publications (16)

Top publication keywords:
Cancer VaccinesTracheaLymphocytes, Tumor-InfiltratingIpilimumabGene DeletionTransgenesProstatic Neoplasms, Castration-ResistantCarcinoma, Pancreatic DuctalTumor MicroenvironmentCell SeparationTh1 CellsAlveolar Epithelial CellsIntegrasesGene Knockout TechniquesTissue Extracts

• Immune modulation with RANKL blockade through denosumab treatment in patients with cancer.
  Cancer immunology research 2024 Chang H, Marquez Garcia J, Chen BK, Kim DM, Cheng ML, Liu EV, Yang H, Zhang L, Sinha M, Cheung A, Kwek SS, Chow ED, Bridge M, Aggarwal RR, Friedlander TW, Small EJ, Anderson M, Fong L
• Modulation of myeloid and T cells in vivo by Bruton's tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma.
  Journal for immunotherapy of cancer 2023 Sinha M, Betts C, Zhang L, Griffith MJ, Solman I, Chen B, Liu E, Tamaki W, Stultz J, Marquez J, Sivagnanam S, Cheung A, Pener D, Fahlman A, Taber E, Lerner K, Crocker M, Todd K, Rajagopalan B, Ware C,…
• Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma.
  Journal for immunotherapy of cancer 2021 Simonds EF, Lu ED, Badillo O, Karimi S, Liu EV, Tamaki W, Rancan C, Downey KM, Stultz J, Sinha M, McHenry LK, Nasholm NM, Chuntova P, Sundström A, Genoud V, Shahani SA, Wang LD, Brown CE, Walker PR, …
• The impact of prior radiation therapy on outcome in a phase 2 trial combining sipuleucel-T (SipT) and ipilimumab (Ipi) in patients (pts) with metastatic castration resistant prostate cancer (mCRPC).
  Journal of Clinical Oncology 2021 Li Zhang, Meenal Sinha, Sumit Kumar Subudhi, Brandon Chen, Jaqueline Marquez, Eric Liu, Kathryn Allaire, Alexander Cheung, Sharon Ng, Christopher Nguyen, Terence W. Friedlander, Rahul Raj Aggarwal, …
• Pre-existing immune status associated with response to combination of sipuleucel-T and ipilimumab in patients with metastatic castration-resistant prostate cancer.
  Journal for immunotherapy of cancer 2021 Sinha M, Zhang L, Subudhi S, Chen B, Marquez J, Liu EV, Allaire K, Cheung A, Ng S, Nguyen C, Friedlander TW, Aggarwal R, Spitzer M, Allison JP, Small EJ, Sharma P, Fong L

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• Efficiency and Specificity of Gene Deletion in Lung Epithelial Doxycycline-Inducible Cre Mice.
  American journal of respiratory cell and molecular biology 2017 Sinha M, Lowell CA
• SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin.
  Nature 2017 Chen J, Zhong MC, Guo H, Davidson D, Mishel S, Lu Y, Rhee I, Pérez-Quintero LA, Zhang S, Cruz-Munoz ME, Wu N, Vinh DC, Sinha M, Calderon V, Lowell CA, Danska JS, Veillette A
• Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9.
  PloS one 2016 Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL
• Isolation of Highly Pure Primary Mouse Alveolar Epithelial Type II Cells by Flow Cytometric Cell Sorting.
  Bio-protocol 2016 Sinha M, Lowell CA
• MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase.
  PLoS pathogens 2016 Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, Wüthrich M
• Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells.
  American journal of respiratory cell and molecular biology 2016 Sinha M, Lowell CA
• FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection.
  PLoS pathogens 2016 Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Lim FY, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy JV
• Regulation of neutrophil cytokine production during inflammation (INC6P.319).
  The Journal of Immunology 2015 Jacques Deguine, Meenal Sinha, Clifford Lowell, Gregory Barton
• The receptor for complement anaphylatoxin C5a protects against the development of airway hyperresponsiveness in allergic asthma by inhibiting cysteinyl leukotriene pathway.
  Molecular Immunology 2008 Meenal Sinha, Scott Drouin, Trent Woodruff, Steve Taylor, Rick Wetsel
• The receptor for complement anaphylatoxin C5a protects against the development of airway hyperresponsiveness in allergic asthma by inhibiting cysteinyl leukotriene pathway.
  The FASEB Journal 2008 Meenal Sinha, Scott Drouin, Rick Wetsel
• Mycobacteria-primed macrophages and dendritic cells induce an up-regulation of complement C5a anaphylatoxin receptor (CD88) in CD3+ murine T cells.
  Journal of leukocyte biology 2006 Connelly MA, Moulton RA, Smith AK, Lindsey DR, Sinha M, Wetsel RA, Jagannath C