Mazen Kheirbek, PhD
Associate Professor
Psychiatry
School of Medicine
Awards
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- McKnight Foundation Memory & Cognitive Disorders Award, 2020
- Human Frontier Science Program, Young Investigator Grant, 2019
- Klingenstein-Simons Fellowship Award in Neuroscience, 2019
- Pew Scholar in Biomedical Sciences, 2019
- Rising Star Award, One Mind, 2016
- Weill Scholar Award, 2016
- The Freedman Prize for Exceptional Basic Research, Honorable Mention, NARSAD, 2014
- Mentored Research Scientist Development Award, NIMH, 2012
- NARSAD Young Investigator Award, 2012
- Harry Ginsburg Memorial Prize in Physiology, 2009
Education & Training
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- Postdoc Columbia University
- PhD University of Chicago
- BA Washington University in St. Louis
Websites
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- @@mazen_kheirbek on Twitter (twitter.com)
- Kheirbek Lab (kheirbeklab.org)
Grants and Projects
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- Circuit dynamics supporting associative learning in the dentate gyrus, NIH/NIDCD, 2021-2026
- Cell-type, circuit and network mechanisms of adult oligodendrogenesis in memory storage and retrieval, NIH/NIMH, 2021-2026
- Hippocampal modulation of subcortical circuits in the control of emotional behavior, NIH/NIMH, 2016-2026
- How is anxiety-related information relayed across hippocampal-prefrontal circuits, NIH/NIMH, 2018-2023
- Circuit and cellular mechanisms of adult neurogenesis in context encoding and discrimination, NIH/NIMH, 2017-2022
Publications (45)
Top publication keywords:
AffectOlfactory PerceptionCorpus StriatumMyelin SheathNeuronsOligodendrocyte Precursor CellsConditioning, ClassicalAnxiety DisordersAssociation LearningDentate GyrusMemory ConsolidationHippocampusFearNeurogenesisCA1 Region, Hippocampal
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Identifying and modulating neural signatures of stress susceptibility and resilience enables control of anhedonia.
Research square 2024 Xia F, Fascianelli V, Vishwakarma N, Ghinger FG, Fusi S, Kheirbek MA -
Neural signatures of stress susceptibility and resilience in the amygdala-hippocampal network.
bioRxiv : the preprint server for biology 2023 Xia F, Fascianelli V, Vishwakarma N, Ghinger FG, Fusi S, Kheirbek MA -
Neural dynamics underlying associative learning in the dorsal and ventral hippocampus.
Nature neuroscience 2023 Biane JS, Ladow MA, Stefanini F, Boddu SP, Fan A, Hassan S, Dundar N, Apodaca-Montano DL, Zhou LZ, Fayner V, Woods NI, Kheirbek MA -
Linking external stimuli with internal drives: A role for the ventral hippocampus.
Current opinion in neurobiology 2022 Turner VS, O'Sullivan RO, Kheirbek MA -
New myelin for old memories.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2022 Kern MC, Kheirbek MA
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Publisher Correction: Circuit and molecular architecture of a ventral hippocampal network.
Nature neuroscience 2021 Gergues MM, Han KJ, Choi HS, Brown B, Clausing KJ, Turner VS, Vainchtein ID, Molofsky AV, Kheirbek MA -
Circuit and molecular architecture of a ventral hippocampal network.
Nature neuroscience 2020 Gergues MM, Han KJ, Choi HS, Brown B, Clausing KJ, Turner VS, Vainchtein ID, Molofsky AV, Kheirbek MA -
Circuit-Based Biomarkers for Mood and Anxiety Disorders.
Trends in neurosciences 2020 Xia F, Kheirbek MA -
Contextual fear memory retrieval by correlated ensembles of ventral CA1 neurons.
Nature communications 2020 Jimenez JC, Berry JE, Lim SC, Ong SK, Kheirbek MA, Hen R -
Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.
Cell 2020 Nguyen PT, Dorman LC, Pan S, Vainchtein ID, Han RT, Nakao-Inoue H, Taloma SE, Barron JJ, Molofsky AB, Kheirbek MA, Molofsky AV -
A Distributed Neural Code in the Dentate Gyrus and in CA1.
Neuron 2020 Stefanini F, Kushnir L, Jimenez JC, Jennings JH, Woods NI, Stuber GD, Kheirbek MA, Hen R, Fusi S -
A neuronal signature for monogamous reunion.
Proceedings of the National Academy of Sciences of the United States of America 2020 Scribner JL, Vance EA, Protter DSW, Sheeran WM, Saslow E, Cameron RT, Klein EM, Jimenez JC, Kheirbek MA, Donaldson ZR -
The Dentate Gyrus Classifies Cortical Representations of Learned Stimuli.
Neuron 2020 Woods NI, Stefanini F, Apodaca-Montano DL, Tan IMC, Biane JS, Kheirbek MA -
Preservation of a remote fear memory requires new myelin formation.
Nature neuroscience 2020 Pan S, Mayoral SR, Choi HS, Chan JR, Kheirbek MA -
Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data.
eLife 2018 Zhou P, Resendez SL, Rodriguez-Romaguera J, Jimenez JC, Neufeld SQ, Giovannucci A, Friedrich J, Pnevmatikakis EA, Stuber GD, Hen R, Kheirbek MA, Sabatini BL, Kass RE, Paninski L -
Anxiety Cells in a Hippocampal-Hypothalamic Circuit.
Neuron 2018 Jimenez JC, Su K, Goldberg AR, Luna VM, Biane JS, Ordek G, Zhou P, Ong SK, Wright MA, Zweifel L, Paninski L, Hen R, Kheirbek MA -
Optogenetic activation of granule cells in the dorsal dentate gyrus enhances dopaminergic neurotransmission in the Nucleus Accumbens.
Neuroscience research 2017 Tritschler L, Kheirbek MA, Dantec YL, Mendez-David I, Guilloux JP, Faye C, Doan J, Pham TH, Hen R, David DJ, Gardier AM -
The Small World of a Fear Memory.
Neuron 2017 Woods NI, Kheirbek MA -
Imaging Adult Hippocampal Neurogenesis In Vivo.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2017 Biane JS, Kheirbek MA -
Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Carvalho Poyraz F, Holzner E, Bailey MR, Meszaros J, Kenney L, Kheirbek MA, Balsam PD, Kellendonk C -
GluN2B-Containg NMDA Receptors on Adult-Born Granule Cells Contribute to the Antidepressant Action of Fluoxetine.
Frontiers in neuroscience 2016 Tannenholz L, Hen R, Kheirbek MA -
Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding.
Neuron 2016 Danielson NB, Kaifosh P, Zaremba JD, Lovett-Barron M, Tsai J, Denny CA, Balough EM, Goldberg AR, Drew LJ, Hen R, Losonczy A, Kheirbek MA -
Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons.
Hippocampus 2016 Drew LJ, Kheirbek MA, Luna VM, Denny CA, Cloidt MA, Wu MV, Jain S, Scharfman HE, Hen R -
Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice.
Neuron 2015 Borgkvist A, Avegno EM, Wong MY, Kheirbek MA, Sonders MS, Hen R, Sulzer D -
Finding the Roots of Adult Neurogenesis.
Cell 2015 Kheirbek MA -
Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.
Cell 2015 Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha … -
Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis.
Neuron 2014 Denny CA, Kheirbek MA, Alba EL, Tanaka KF, Brachman RA, Laughman KB, Tomm NK, Turi GF, Losonczy A, Hen R -
Add neurons, subtract anxiety.
Scientific American 2014 Kheirbek MA, Hen R -
Local and regional heterogeneity underlying hippocampal modulation of cognition and mood.
Frontiers in behavioral neuroscience 2014 Tannenholz L, Jimenez JC, Kheirbek MA -
Dendritic inhibition in the hippocampus supports fear learning.
Science (New York, N.Y.) 2014 Lovett-Barron M, Kaifosh P, Kheirbek MA, Danielson N, Zaremba JD, Reardon TR, Turi GF, Hen R, Zemelman BV, Losonczy A -
Repeated cortico-striatal stimulation generates persistent OCD-like behavior.
Science (New York, N.Y.) 2013 Ahmari SE, Spellman T, Douglass NL, Kheirbek MA, Simpson HB, Deisseroth K, Gordon JA, Hen R -
(Radio)active neurogenesis in the human hippocampus.
Cell 2013 Kheirbek MA, Hen R -
Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus.
Neuron 2013 Kheirbek MA, Drew LJ, Burghardt NS, Costantini DO, Tannenholz L, Ahmari SE, Zeng H, Fenton AA, Hen R -
Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders.
Nature neuroscience 2012 Kheirbek MA, Klemenhagen KC, Sahay A, Hen R -
NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Kheirbek MA, Tannenholz L, Hen R -
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation.
Nature 2011 Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS, Fenton AA, Dranovsky A, Hen R -
Dorsal vs ventral hippocampal neurogenesis: implications for cognition and mood.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011 Kheirbek MA, Hen R -
Dopamine-dependent motor learning: insight into levodopa's long-duration response.
Annals of neurology 2010 Beeler JA, Cao ZF, Kheirbek MA, Ding Y, Koranda J, Murakami M, Kang UJ, Zhuang X -
A molecular dissociation between cued and contextual appetitive learning.
Learning & memory (Cold Spring Harbor, N.Y.) 2010 Kheirbek MA, Beeler JA, Chi W, Ishikawa Y, Zhuang X -
Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Kheirbek MA, Britt JP, Beeler JA, Ishikawa Y, McGehee DS, Zhuang X -
A cAMP pathway underlying reward prediction in associative learning.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Kheirbek MA, Beeler JA, Ishikawa Y, Zhuang X -
Loss of cocaine locomotor response in Pitx3-deficient mice lacking a nigrostriatal pathway.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008 Beeler JA, Cao ZF, Kheirbek MA, Zhuang X -
A molecular switch for induction of long-term depression of corticostriatal transmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Kheirbek MA -
Hox gene misexpression and cell-specific lesions reveal functionality of homeotically transformed neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Hale ME, Kheirbek MA, Schriefer JE, Prince VE -
Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention.
Development (Cambridge, England) 2002 McClintock JM, Kheirbek MA, Prince VE