Max Krummel, PhD
Professor
Pathology
School of Medicine

Websites

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• Professional Website (matthewkrummel.org)
• Profile at pathology.ucsf.edu (pathology.ucsf.edu)
• Biological Imaging Development Center (pathology.ucsf.edu)

Grants and Projects

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• Understanding Asthma Endotypes, NIH, 2008-2023
• Manipulating collectivity and Niches for Developing CD8 Immunity, NIH, 2015-2020
• Living Tumor Biopsies to Interrogate Immune Function and Response to Therapy, NIH, 2015-2018
• Cytoskeletal Regulation of T cell Motility and Synaptic Signaling, NIH, 2002-2017
• Leukocyte Biomarkers for Predicting Human Breast Cancer Outcomes, NIH, 2011-2017
• Cutting Edge Lineage Tracking of Tumor-educated Immune Cells, NIH, 2015-2016
• Epithelial Progenitor Cells in Lung Repair and Regeneration, NIH, 2012-2016
• Evolving Microenvironments in Airway Inflammation, NIH, 1979-2016
• Collaborative Innate-Adaptive Immune Regulation of Tumor Progression, NIH, 2009-2014
• Defining the First Hours of Lung metastasis using Intravital Live-Imaging, NIH, 2012-2014
• Multiphoton Instrumentation for Translational Assays from Human Tissue Biopsies, NIH, 2011-2013
• Regulation of T cell Functions by the Breast Cancer Microenvironment, NIH, 2009-2011
• New Models for Molecular-Level Imaging of Cell Signaling in vivo., NIH, 2008-2010
• Imaging-Based Analysis of Tolerance-Induction Mechanisms, NIH, 2005-2008
• Genes Associated with Postthymic T Cell Differentiation, NIH, 1998-2000

Publications (196)

Top publication keywords:
Lymphocyte ActivationImmunological SynapsesNeoplasmsDendritic CellsCell CommunicationReceptors, Antigen, T-CellMicrovilliT-LymphocytesNonmuscle Myosin Type IIATumor MicroenvironmentCD8-Positive T-LymphocytesAntigen PresentationAntigen-Presenting CellsCell MovementMyeloid Cells

• Visualization of immediate immune responses to pioneer metastatic cells in the lung.
  Nature 2016 Headley MB, Bins A, Nip A, Roberts EW, Looney MR, Gerard A, Krummel MF
• Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.
  Cancer cell 2014 Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF
• Targeting CD206+ macrophages disrupts the establishment of a key antitumor immune axis.
  The Journal of experimental medicine 2024 Ray A, Hu KH, Kersten K, Courau T, Kuhn NF, Zaleta-Linares I, Samad B, Combes AJ, Krummel MF
• Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia.
  Nature communications 2024 Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC, COMET …
• Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer.
  bioRxiv : the preprint server for biology 2024 Cleary SJ, Qiu L, Seo Y, Baluk P, Liu D, Serwas NK, Cyster JG, McDonald DM, Krummel MF, Looney MR

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• Immediate myeloid depot for SARS-CoV-2 in the human lung.
  Science advances 2024 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, …
• Localized in vivo gene editing of murine cancer-associated fibroblasts.
  bioRxiv : the preprint server for biology 2024 Kuhn NF, Zaleta-Linares I, Nyberg WA, Eyquem J, Krummel MF
• Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.
  Nature communications 2024 Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK
• Critical role of CD206+ macrophages in promoting a cDC1-NK-CD8 T cell anti-tumor immune axis.
  bioRxiv : the preprint server for biology 2024 Ray A, Hu KH, Kersten K, Courau T, Kuhn NF, Zaleta-Linares I, Samad B, Combes AJ, Krummel MF
• Multimodal identification of rare potent effector CD8 T cells in solid tumors.
  bioRxiv : the preprint server for biology 2023 Ray A, Bassette M, Hu KH, Pass LF, Samad B, Combes A, Johri V, Davidson B, Hernandez G, Zaleta-Linares I, Krummel MF
• Cyclone: an accessible pipeline to analyze, evaluate, and optimize multiparametric cytometry data.
  Frontiers in immunology 2023 Patel RK, Jaszczak RG, Im K, Carey ND, Courau T, Bunis DG, Samad B, Avanesyan L, Chew NW, Stenske S, Jespersen JM, Publicover J, Edwards AW, Naser M, Rao AA, Lupin-Jimenez L, Krummel MF, Cooper S, …
• A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling.
  iScience 2023 Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, …
• Metabolic programs of T cell tissue residency empower tumour immunity.
  Nature 2023 Reina-Campos M, Heeg M, Kennewick K, Mathews IT, Galletti G, Luna V, Nguyen Q, Huang H, Milner JJ, Hu KH, Vichaidit A, Santillano N, Boland BS, Chang JT, Jain M, Sharma S, Krummel MF, Chi H, Bensinger…
• TREM1 activation of myeloid cells promotes antitumor immunity.
  Science translational medicine 2023 Juric V, Mayes E, Binnewies M, Lee T, Canaday P, Pollack JL, Rudolph J, Du X, Liu VM, Dash S, Palmer R, Jahchan NS, Ramoth ÅJ, Lacayo S, Mankikar S, Norng M, Brassell C, Pal A, Chan C, Lu E, Sriram V,…
• Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.
  Research square 2023 Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK
• Tumor cell heterogeneity drives spatial organization of the intratumoral immune response in squamous cell skin carcinoma.
  bioRxiv : the preprint server for biology 2023 Tanaka M, Lum L, Hu K, Ledezma-Soto C, Samad B, Superville D, Ng K, Adams Z, Kersten K, Fong L, Combes AJ, Krummel M, Reeves M
• Defining and using immune archetypes to classify and treat cancer.
  Nature reviews. Cancer 2023 Combes AJ, Samad B, Krummel MF
• Transcriptional space-time mapping identifies concerted immune and stromal cell patterns and gene programs in wound healing and cancer.
  Cell stem cell 2023 Hu KH, Kuhn NF, Courau T, Tsui J, Samad B, Ha P, Kratz JR, Combes AJ, Krummel MF
• Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung.
  Cell reports 2023 Kersten K, You R, Liang S, Tharp KM, Pollack J, Weaver VM, Krummel MF, Headley MB
• Polyunsaturated Fatty Acid-Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism.
  Cancer research 2023 Munson PV, Adamik J, Hartmann FJ, Favaro PMB, Ho D, Bendall SC, Combes AJ, Krummel MF, Zhang K, Kelley RK, Butterfield LH
• High-dimensional immune cell profiling of cerebrospinal fluid from patients with metastatic breast cancer and leptomeningeal disease.
  NPJ breast cancer 2023 Im KW, Huppert LA, Malevanchik L, Rugo HS, Combes AJ, Campbell MJ, Krummel MF, Melisko ME
• Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes.
  Cell 2023 Rahim MK, Okholm TLH, Jones KB, McCarthy EE, Liu CC, Yee JL, Tamaki SJ, Marquez DM, Tenvooren I, Wai K, Cheung A, Davidson BR, Johri V, Samad B, O'Gorman WE, Krummel MF, van Zante A, Combes AJ, Angelo…
• Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations.
  The Journal of clinical investigation 2023 Marsan E, Velmeshev D, Ramsey A, Patel RK, Zhang J, Koontz M, Andrews MG, de Majo M, Mora C, Blumenfeld J, Li AN, Spina S, Grinberg LT, Seeley WW, Miller BL, Ullian EM, Krummel MF, Kriegstein AR, …
• Cyclone: an accessible pipeline to analyze, evaluate and optimize multiparametric cytometry data.
  bioRxiv : the preprint server for biology 2023 Patel RK, Jaszczak RG, Kwok I, Carey ND, Courau T, Bunis D, Samad B, Avanesyan L, Chew NW, Stenske S, Jespersen JM, Publicover J, Edwards A, Naser M, Rao AA, Lupin-Jimenez L, Krummel MF, Cooper S, …
• SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.
  Stem cell reports 2023 Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, …
• Hyperstabilization of T cell microvilli contacts by chimeric antigen receptors.
  The Journal of cell biology 2022 Beppler C, Eichorst J, Marchuk K, Cai E, Castellanos CA, Sriram V, Roybal KT, Krummel MF
• COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective.
  American journal of respiratory and critical care medicine 2022 Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COVID…
• Distinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells.
  Nature communications 2022 Adamik J, Munson PV, Hartmann FJ, Combes AJ, Pierre P, Krummel MF, Bendall SC, Argüello RJ, Butterfield LH
• Impact of protein identity on tumor-associated antigen uptake into infiltrating immune cells: A comparison of different fluorescent proteins as model antigens.
  PloS one 2022 Yi R, Chen E, Roberts EW, Krummel MF, Serwas NK
• T cells use distinct topographical and membrane receptor scanning strategies that individually coalesce during receptor recognition.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Cai E, Beppler C, Eichorst J, Marchuk K, Eastman SW, Krummel MF
• Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients.
  Immunity 2022 Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Munoz Sandoval P, Willmore A, UCSF COMET Consortium, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Calfee CS, Erle DJ…
• Visualizing Spatial and Stoichiometric Barriers to Bispecific T-Cell Engager Efficacy.
  Cancer immunology research 2022 You R, Artichoker J, Ray A, Gonzalez Velozo H, Rock DA, Conner KP, Krummel MF
• Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer.
  Cancer cell 2022 Kersten K, Hu KH, Combes AJ, Samad B, Harwin T, Ray A, Rao AA, Cai E, Marchuk K, Artichoker J, Courau T, Shi Q, Belk J, Satpathy AT, Krummel MF
• Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer.
  Cell reports 2022 Laviron M, Petit M, Weber-Delacroix E, Combes AJ, Arkal AR, Barthélémy S, Courau T, Hume DA, Combadière C, Krummel MF, Boissonnas A
• Immediate myeloid depot for SARS-CoV-2 in the human lung.
  Research square 2022 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, …
• Immediate myeloid depot for SARS-CoV-2 in the human lung.
  bioRxiv : the preprint server for biology 2022 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, …
• Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer.
  Cancer immunology research 2022 Mujal AM, Combes AJ, Rao AA, Binnewies M, Samad B, Tsui J, Boissonnas A, Pollack JL, Argüello RJ, Meng MV, Porten SP, Ruhland MK, Barry KC, Chan V, Krummel MF
• A conserved immune trajectory of recovery in hospitalized COVID-19 patients.
  bioRxiv : the preprint server for biology 2022 Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Sandoval PM, UCSF COMET Consortium, Calfee CS, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Erle DJ, Ansel KM, …
• Discovering dominant tumor immune archetypes in a pan-cancer census.
  Cell 2021 Combes AJ, Samad B, Tsui J, Chew NW, Yan P, Reeder GC, Kushnoor D, Shen A, Davidson B, Barczak AJ, Adkisson M, Edwards A, Naser M, Barry KC, Courau T, Hammoudi T, Argüello RJ, Rao AA, Olshen AB, …
• Genetic and immunologic features of recurrent stage I lung adenocarcinoma.
  Scientific reports 2021 Kratz JR, Li JZ, Tsui J, Lee JC, Ding VW, Rao AA, Mann MJ, Chan V, Combes AJ, Krummel MF, Jablons DM
• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
  medRxiv : the preprint server for health sciences 2021 Tsitsiklis A, Zha BS, Byrne A, DeVoe C, Rackaityte E, Levan S, Sunshine S, Mick E, Ghale R, Love C, Tarashansky AJ, Pisco A, Albright J, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, …
• Targeting TREM2 on tumor-associated macrophages enhances immunotherapy.
  Cell reports 2021 Binnewies M, Pollack JL, Rudolph J, Dash S, Abushawish M, Lee T, Jahchan NS, Canaday P, Lu E, Norng M, Mankikar S, Liu VM, Du X, Chen A, Mehta R, Palmer R, Juric V, Liang L, Baker KP, Reyno L, Krummel…
• Archetypes of checkpoint-responsive immunity.
  Trends in immunology 2021 Im K, Combes AJ, Spitzer MH, Satpathy AT, Krummel MF
• Activating Immune Recognition in Pancreatic Ductal Adenocarcinoma via Autophagy Inhibition, MEK Blockade, and CD40 Agonism.
  Gastroenterology 2021 Jiang H, Courau T, Borison J, Ritchie AJ, Mayer AT, Krummel MF, Collisson EA
• Active surveillance characterizes human intratumoral T cell exhaustion.
  The Journal of clinical investigation 2021 You R, Artichoker J, Fries A, Edwards AW, Combes AJ, Reeder GC, Samad B, Krummel MF
• Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.
  EClinicalMedicine 2021 Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J,…
• Layilin Anchors Regulatory T Cells in Skin.
  Journal of immunology (Baltimore, Md. : 1950) 2021 Mehta P, Gouirand V, Boda DP, Zhang J, Gearty SV, Zirak B, Lowe MM, Clancy S, Boothby I, Mahuron KM, Fries A, Krummel MF, Mankoo P, Chang HW, Liu J, Moreau JM, Scharschmidt TC, Daud A, Kim E, Neuhaus …
• Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.
  Nature communications 2021 Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, …
• Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19.
  Science translational medicine 2021 van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, …
• Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19.
  Nature 2021 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• The WAVE complex associates with sites of saddle membrane curvature.
  The Journal of cell biology 2021 Pipathsouk A, Brunetti RM, Town JP, Graziano BR, Breuer A, Pellett PA, Marchuk K, Tran NT, Krummel MF, Stamou D, Weiner OD
• SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.
  bioRxiv : the preprint server for biology 2021 Hysenaj L, Little S, Kulhanek K, Gbenedio OM, Rodriguez L, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Bahl K, Mick E, Li JZ, Ding VW, Matsumoto S, Maishan M, Simoneau C, Fragiadakis G, …
• DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells.
  Journal for immunotherapy of cancer 2021 Cueto FJ, Del Fresno C, Brandi P, Combes AJ, Hernández-García E, Sánchez-Paulete AR, Enamorado M, Bromley CP, Gomez MJ, Conde-Garrosa R, Mañes S, Zelenay S, Melero I, Iborra S, Krummel MF, Sancho D
• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
  Research square 2021 Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson…
• A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8.
  Science immunology 2021 Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL
• Learned adaptive multiphoton illumination microscopy for large-scale immune response imaging.
  Nature communications 2021 Pinkard H, Baghdassarian H, Mujal A, Roberts E, Hu KH, Friedman DH, Malenica I, Shagam T, Fries A, Corbin K, Krummel MF, Waller L
• Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19: Anti-IFN antibodies in critical COVID-19 correlate with poor ISG response and upregulation of LAIR1 surface protein in PBMCs.
  bioRxiv : the preprint server for biology 2021 van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, …
• A "data sharing trust" model for rapid, collaborative science.
  Cell 2021 Chan V, Gherardini PF, Krummel MF, Fragiadakis GK
• Global absence and targeting of protective immune states in severe COVID-19.
  Nature 2021 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.
  Research square 2021 Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, …
• Visualizing Cancer.
  Cancer cell 2020 Krummel M, Hu K, de Vries EGE, Goetz JG, Passaro D, Subramaniam S, Misteli T, Skala M, Bravo-Cordero JJ, Sutcliffe JL
• SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution.
  Cell metabolism 2020 Argüello RJ, Combes AJ, Char R, Gigan JP, Baaziz AI, Bousiquot E, Camosseto V, Samad B, Tsui J, Yan P, Boissonneau S, Figarella-Branger D, Gatti E, Tabouret E, Krummel MF, Pierre P
• Global Absence and Targeting of Protective Immune States in Severe COVID-19.
  bioRxiv : the preprint server for biology 2020 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Global Absence and Targeting of Protective Immune States in Severe COVID-19.
  Research square 2020 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Lessons of COVID-19: A roadmap for post-pandemic science.
  The Journal of experimental medicine 2020 Freedman TS, Headley MB, Serwas N, Ruhland M, Castellanos CA, Combes AJ, Krummel MF
• The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies.
  Nature immunology 2020 Bald T, Krummel MF, Smyth MJ, Barry KC
• ZipSeq: barcoding for real-time mapping of single cell transcriptomes.
  Nature methods 2020 Hu KH, Eichorst JP, McGinnis CS, Patterson DM, Chow ED, Kersten K, Jameson SC, Gartner ZJ, Rao AA, Krummel MF
• Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells.
  Cancer cell 2020 Ruhland MK, Roberts EW, Cai E, Mujal AM, Marchuk K, Beppler C, Nam D, Serwas NK, Binnewies M, Krummel MF
• Tumor Immune Profiling-Based Neoadjuvant Immunotherapy for Locally Advanced Melanoma.
  Annals of surgical oncology 2020 Levine LS, Mahuron KM, Tsai KK, Wu C, Mattis DM, Pauli ML, Oglesby A, Lee JC, Spitzer MH, Krummel MF, Algazi AP, Rosenblum MD, Alvarado M, Daud AI
• Carpet-bombing tumors with IFN-γ.
  Nature cancer 2020 Hu KH, Krummel MF
• Spacer-Mediated Control of Coumarin Uncaging for Photocaged Thymidine.
  The Journal of organic chemistry 2020 Tang S, Cannon J, Yang K, Krummel MF, Baker JR, Choi SK
• Reinvigorating NIH Grant Peer Review.
  Immunity 2020 Crotty S, Blish C, Cadwell K, Chi H, Goldrath A, Green D, Kaech SM, Krummel M, Pepper M, Rothlin CV, Wherry EJ, Once-a-Year Pledge Supporters
• mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse.
  Science advances 2020 Thumkeo D, Katsura Y, Nishimura Y, Kanchanawong P, Tohyama K, Ishizaki T, Kitajima S, Takahashi C, Hirata T, Watanabe N, Krummel MF, Narumiya S
• Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.
  JCI insight 2019 Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, …
• Universal Principled Review: A Community-Driven Method to Improve Peer Review.
  Cell 2019 Krummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel KM, Chi H, O'Connell R, Wherry EJ, Pepper M, Future Immunology Consortium
• Dendritic cells in cancer immunology and immunotherapy.
  Nature reviews. Immunology 2019 Wculek SK, Cueto FJ, Mujal AM, Melero I, Krummel MF, Sancho D
• Tuning the Tumor Myeloid Microenvironment to Fight Cancer.
  Frontiers in immunology 2019 Jahchan NS, Mujal AM, Pollack JL, Binnewies M, Sriram V, Reyno L, Krummel MF
• Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans.
  Science immunology 2019 Puttur F, Denney L, Gregory LG, Vuononvirta J, Oliver R, Entwistle LJ, Walker SA, Headley MB, McGhee EJ, Pease JE, Krummel MF, Carlin LM, Lloyd CM
• Immunity as a continuum of archetypes.
  Science (New York, N.Y.) 2019 Mujal AM, Krummel MF
• Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity.
  Cell 2019 Binnewies M, Mujal AM, Pollack JL, Combes AJ, Hardison EA, Barry KC, Tsui J, Ruhland MK, Kersten K, Abushawish MA, Spasic M, Giurintano JP, Chan V, Daud AI, Ha P, Ye CJ, Roberts EW, Krummel MF
• α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas.
  Journal for immunotherapy of cancer 2019 Dodagatta-Marri E, Meyer DS, Reeves MQ, Paniagua R, To MD, Binnewies M, Broz ML, Mori H, Wu D, Adoumie M, Del Rosario R, Li O, Buchmann T, Liang B, Malato J, Arce Vargus F, Sheppard D, Hann BC, Mirza …
• Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches.
  Immunity 2019 Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB
• Nobel notes value of basic research for new drugs.
  Nature 2018 Krummel M
• Paracrine costimulation of IFN-γ signaling by integrins modulates CD8 T cell differentiation.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Krummel MF, Mahale JN, Uhl LFK, Hardison EA, Mujal AM, Mazet JM, Weber RJ, Gartner ZJ, Gérard A
• Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.
  Mucosal immunology 2018 Hung LY, Sen D, Oniskey TK, Katzen J, Cohen NA, Vaughan AE, Nieves W, Urisman A, Beers MF, Krummel MF, Herbert DR
• A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments.
  Nature medicine 2018 Barry KC, Hsu J, Broz ML, Cueto FJ, Binnewies M, Combes AJ, Nelson AE, Loo K, Kumar R, Rosenblum MD, Alvarado MD, Wolf DM, Bogunovic D, Bhardwaj N, Daud AI, Ha PK, Ryan WR, Pollack JL, Samad B, …
• Subcellular Localization of Antigen in Keratinocytes Dictates Delivery of CD4+ T-cell Help for the CTL Response upon Therapeutic DNA Vaccination into the Skin.
  Cancer immunology research 2018 Babala N, Bovens A, de Vries E, Iglesias-Guimarais V, Ahrends T, Krummel MF, Borst J, Bins AD
• Understanding the tumor immune microenvironment (TIME) for effective therapy.
  Nature medicine 2018 Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, …
• Trefoil Factor 2 Promotes Type 2 Immunity and Lung Repair through Intrinsic Roles in Hematopoietic and Nonhematopoietic Cells.
  The American journal of pathology 2018 Hung LY, Oniskey TK, Sen D, Krummel MF, Vaughan AE, Cohen NA, Herbert DR
• TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer.
  Cancer cell 2018 de Mingo Pulido Á, Gardner A, Hiebler S, Soliman H, Rugo HS, Krummel MF, Coussens LM, Ruffell B
• Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy.
  JCI insight 2017 Loo K, Tsai KK, Mahuron K, Liu J, Pauli ML, Sandoval PM, Nosrati A, Lee J, Chen L, Hwang J, Levine LS, Krummel MF, Algazi AP, Pampaloni M, Alvarado MD, Rosenblum MD, Daud AI
• Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.
  Science (New York, N.Y.) 2017 Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu TL, Chen BC, Betzig E, Bartumeus F, Krummel MF
• The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection.
  Science immunology 2017 Yipp BG, Kim JH, Lima R, Zbytnuik LD, Petri B, Swanlund N, Ho M, Szeto VG, Tak T, Koenderman L, Pickkers P, Tool ATJ, Kuijpers TW, van den Berg TK, Looney MR, Krummel MF, Kubes P
• Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC.
  Cancer immunology research 2017 Tumeh PC, Hellmann MD, Hamid O, Tsai KK, Loo KL, Gubens MA, Rosenblum M, Harview CL, Taube JM, Handley N, Khurana N, Nosrati A, Krummel MF, Tucker A, Sosa EV, Sanchez PJ, Banayan N, Osorio JC, Nguyen-…
• The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors.
  Nature 2017 Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR
• Control of an Unusual Photo-Claisen Rearrangement in Coumarin Caged Tamoxifen through an Extended Spacer.
  ACS chemical biology 2017 Wong PT, Roberts EW, Tang S, Mukherjee J, Cannon J, Nip AJ, Corbin K, Krummel MF, Choi SK
• Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine.
  JCI insight 2016 Boldajipour B, Nelson A, Krummel MF
• Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.
  The Journal of clinical investigation 2016 Starobinets H, Ye J, Broz M, Barry K, Goldsmith J, Marsh T, Rostker F, Krummel M, Debnath J
• Tracking the Spatial and Functional Gradient of Monocyte-To-Macrophage Differentiation in Inflamed Lung.
  PloS one 2016 Sen D, Jones SM, Oswald EM, Pinkard H, Corbin K, Krummel MF
• CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses.
  The Journal of experimental medicine 2016 Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, …
• Micro-Magellan: open-source, sample-adaptive, acquisition software for optical microscopy.
  Nature methods 2016 Pinkard H, Stuurman N, Corbin K, Vale R, Krummel MF
• CCR2 Influences T Regulatory Cell Migration to Tumors and Serves as a Biomarker of Cyclophosphamide Sensitivity.
  Cancer research 2016 Loyher PL, Rochefort J, Baudesson de Chanville C, Hamon P, Lescaille G, Bertolus C, Guillot-Delost M, Krummel MF, Lemoine FM, Combadière C, Boissonnas A
• iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation.
  Cell reports 2016 Thanabalasuriar A, Neupane AS, Wang J, Krummel MF, Kubes P
• Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma.
  The Journal of clinical investigation 2016 Daud AI, Loo K, Pauli ML, Sanchez-Rodriguez R, Sandoval PM, Taravati K, Tsai K, Nosrati A, Nardo L, Alvarado MD, Algazi AP, Pampaloni MH, Lobach IV, Hwang J, Pierce RH, Gratz IK, Krummel MF, Rosenblum…
• Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma.
  Cancer cell 2016 Roberts EW, Broz ML, Binnewies M, Headley MB, Nelson AE, Wolf DM, Kaisho T, Bogunovic D, Bhardwaj N, Krummel MF
• Spatiotemporal Rank Filtering Improves Image Quality Compared to Frame Averaging in 2-Photon Laser Scanning Microscopy.
  PloS one 2016 Pinkard H, Corbin K, Krummel MF
• T cell migration, search strategies and mechanisms.
  Nature reviews. Immunology 2016 Krummel MF, Bartumeus F, Gérard A
• STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis.
  Cancer research 2015 Jones LM, Broz ML, Ranger JJ, Ozcelik J, Ahn R, Zuo D, Ursini-Siegel J, Hallett MT, Krummel M, Muller WJ
• A septin requirement differentiates autonomous and contact-facilitated T cell proliferation.
  Nature immunology 2015 Mujal AM, Gilden JK, Gérard A, Kinoshita M, Krummel MF
• Adaptive Immune Regulation of Mammary Postnatal Organogenesis.
  Developmental cell 2015 Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z
• TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL
• The emerging understanding of myeloid cells as partners and targets in tumor rejection.
  Cancer immunology research 2015 Broz ML, Krummel MF
• Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice.
  PloS one 2015 Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF
• A critical role for dendritic cells in the evolution of IL-1β-mediated murine airway disease.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Goodsell A, Ma R, Moermans C, McKnelly KJ, Baron JL, Krummel MF, Nishimura SL
• The subtle hands of self-reactivity in peripheral T cells.
  Nature immunology 2015 Mujal AM, Krummel M
• Antigen recognition in the islets changes with progression of autoimmune islet infiltration.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Lindsay RS, Corbin K, Mahne A, Levitt BE, Gebert MJ, Wigton EJ, Bradley BJ, Haskins K, Jacobelli J, Tang Q, Krummel MF, Friedman RS
• Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity.
  Cancer cell 2014 Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF
• Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.
  Blood 2014 Ortiz-Muñoz G, Mallavia B, Bins A, Headley M, Krummel MF, Looney MR
• Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.
  Cell stem cell 2014 Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE
• Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g.
  Cell 2014 Gérard A, Patino-Lopez G, Beemiller P, Nambiar R, Ben-Aissa K, Liu Y, Totah FJ, Tyska MJ, Shaw S, Krummel MF
• Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice.
  PloS one 2014 Li M, Wetzel-Strong SE, Hua X, Tilley SL, Oswald E, Krummel MF, Caron KM
• The spatiotemporal cellular dynamics of lung immunity.
  Trends in immunology 2014 Lelkes E, Headley MB, Thornton EE, Looney MR, Krummel MF
• An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Friedman RS, Lindsay RS, Lilly JK, Nguyen V, Sorensen CM, Jacobelli J, Krummel MF
• Modes and mechanisms of T cell motility: roles for confinement and Myosin-IIA.
  Current opinion in cell biology 2014 Krummel MF, Friedman RS, Jacobelli J
• Leukotriene B4 amplifies eosinophil accumulation in response to nematodes.
  The Journal of experimental medicine 2014 Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD
• Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.
  Immunity 2014 Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM
• Assessing and benchmarking multiphoton microscopes for biologists.
  Methods in cell biology 2014 Corbin K, Pinkard H, Peck S, Beemiller P, Krummel MF
• Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm.
  Immunological reviews 2013 Beemiller P, Krummel MF
• Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers.
  PloS one 2013 Jacobelli J, Estin Matthews M, Chen S, Krummel MF
• Type 2 innate lymphoid cells control eosinophil homeostasis.
  Nature 2013 Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM
• Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells.
  Nature immunology 2013 Gérard A, Khan O, Beemiller P, Oswald E, Hu J, Matloubian M, Krummel MF
• Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E.
  Immunity 2013 Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM
• Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses.
  Immunological reviews 2013 Gérard A, Beemiller P, Friedman RS, Jacobelli J, Krummel MF
• Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells.
  Journal of immunology (Baltimore, Md. : 1950) 2012 Zhang Y, Chen YC, Krummel MF, Rosen SD
• Integration of the movement of signaling microclusters with cellular motility in immunological synapses.
  Nature immunology 2012 Beemiller P, Jacobelli J, Krummel MF
• Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung.
  The Journal of experimental medicine 2012 Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF
• Live imaging of the lung.
  Current protocols in cytometry 2012 Thornton EE, Krummel MF, Looney MR
• Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells.
  Cancer cell 2012 Engelhardt JJ, Boldajipour B, Beemiller P, Pandurangi P, Sorensen C, Werb Z, Egeblad M, Krummel MF
• The septin cytoskeleton facilitates membrane retraction during motility and blebbing.
  The Journal of cell biology 2012 Gilden JK, Peck S, Chen YC, Krummel MF
• Regulation of T cell priming by lymphoid stroma.
  PloS one 2011 Khan O, Headley M, Gerard A, Wei W, Liu L, Krummel MF
• Pillars article: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. The journal of experimental medicine. 1995. 182: 459-465.
  Journal of immunology (Baltimore, Md. : 1950) 2011 Krummel MF, Allison JP
• Stabilized imaging of immune surveillance in the mouse lung.
  Nature methods 2010 Looney MR, Thornton EE, Sen D, Lamm WJ, Glenny RW, Krummel MF
• Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics.
  The Journal of experimental medicine 2010 Friedman RS, Beemiller P, Sorensen CM, Jacobelli J, Krummel MF
• Duration of antigen receptor signaling determines T-cell tolerance or activation.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Katzman SD, O'Gorman WE, Villarino AV, Gallo E, Friedman RS, Krummel MF, Nolan GP, Abbas AK
• Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions.
  Nature immunology 2010 Jacobelli J, Friedman RS, Conti MA, Lennon-Dumenil AM, Piel M, Sorensen CM, Adelstein RS, Krummel MF
• Mediation of T-cell activation by actin meshworks.
  Cold Spring Harbor perspectives in biology 2010 Beemiller P, Krummel MF
• Control of cortical rigidity by the cytoskeleton: emerging roles for septins.
  Cytoskeleton (Hoboken, N.J.) 2010 Gilden J, Krummel MF
• Illuminating emergent activity in the immune system by real-time imaging.
  Nature immunology 2010 Krummel MF
• The immunological synapse: a dynamic platform for local signaling.
  Journal of clinical immunology 2010 Krummel MF, Cahalan MD
• Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions.
  Biomaterials 2010 Doh J, Kim M, Krummel MF
• Immunological synapses within context: patterns of cell-cell communication and their application in T-T interactions.
  Current topics in microbiology and immunology 2010 Doh J, Krummel MF
• Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.
  Nature immunology 2009 Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA
• Matthew Krummel: visions enumerated. Interview by Amy Maxmen.
  The Journal of experimental medicine 2009 Krummel M
• Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Melli K, Friedman RS, Martin AE, Finger EB, Miao G, Szot GL, Krummel MF, Tang Q
• Myosin-IIA and ICAM-1 regulate the interchange between two distinct modes of T cell migration.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Jacobelli J, Bennett FC, Pandurangi P, Tooley AJ, Krummel MF
• Two-photon imaging of the immune system: a custom technology platform for high-speed, multicolor tissue imaging of immune responses.
  Current topics in microbiology and immunology 2009 Bullen A, Friedman RS, Krummel MF
• Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility.
  Nature cell biology 2008 Tooley AJ, Gilden J, Jacobelli J, Beemiller P, Trimble WS, Kinoshita M, Krummel MF
• Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL
• Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy.
  Disease models & mechanisms 2008 Egeblad M, Ewald AJ, Askautrud HA, Truitt ML, Welm BE, Bainbridge E, Peeters G, Krummel MF, Werb Z
• Deletional tolerance mediated by extrathymic Aire-expressing cells.
  Science (New York, N.Y.) 2008 Gardner JM, Devoss JJ, Friedman RS, Wong DJ, Tan YX, Zhou X, Johannes KP, Su MA, Chang HY, Krummel MF, Anderson MS
• Distinct functions for HS1 in chemosensory versus adhesive signaling.
  Nature immunology 2008 Beemiller P, Krummel MF
• A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction.
  Immunity 2008 Sabatos CA, Doh J, Chakravarti S, Friedman RS, Pandurangi PG, Tooley AJ, Krummel MF
• The importance of prolonged binding to antigen-presenting cells for T cell fate decisions.
  Immunity 2008 Engelhardt JJ, Krummel MF
• Testing the organization of the immunological synapse.
  Current opinion in immunology 2007 Krummel MF
• Immunological synapses: breaking up may be good to do.
  Cell 2007 Krummel MF
• Maintenance and modulation of T cell polarity.
  Nature immunology 2006 Krummel MF, Macara I
• Surface-bound chemokines capture and prime T cells for synapse formation.
  Nature immunology 2006 Friedman RS, Jacobelli J, Krummel MF
• Imaging the function of regulatory T cells in vivo.
  Current opinion in immunology 2006 Tang Q, Krummel MF
• Triggering of T cell activation via CD4 dimers.
  Journal of immunology (Baltimore, Md. : 1950) 2006 Moldovan MC, Sabbagh L, Breton G, Sékaly RP, Krummel MF
• Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.
  Nature immunology 2005 Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA
• Mechanisms of T cell motility and arrest: deciphering the relationship between intra- and extracellular determinants.
  Seminars in immunology 2005 Friedman RS, Jacobelli J, Krummel MF
• Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.
  PLoS biology 2005 Okada T, Miller MJ, Parker I, Krummel MF, Neighbors M, Hartley SB, O'Garra A, Cahalan MD, Cyster JG
• T cell synapse assembly: proteins, motors and the underlying cell biology.
  Seminars in immunology 2005 Tooley AJ, Jacobelli J, Moldovan MC, Douglas A, Krummel MF
• Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Boisvert J, Edmondson S, Krummel MF
• New views of the immunological synapse: variations in assembly and function.
  Current opinion in immunology 2004 Jacobelli J, Andres PG, Boisvert J, Krummel MF
• CD28 signals in the immature immunological synapse.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Andres PG, Howland KC, Dresnek D, Edmondson S, Abbas AK, Krummel MF
• A single class II myosin modulates T cell motility and stopping, but not synapse formation.
  Nature immunology 2004 Jacobelli J, Chmura SA, Buxton DB, Davis MM, Krummel MF
• Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation.
  Immunity 2002 Ehrlich LI, Ebert PJ, Krummel MF, Weiss A, Davis MM
• Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Moss WC, Irvine DJ, Davis MM, Krummel MF
• Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection.
  Immunity 2002 Richie LI, Ebert PJ, Wu LC, Krummel MF, Owen JJ, Davis MM
• Dynamics of the immunological synapse: finding, establishing and solidifying a connection.
  Current opinion in immunology 2002 Krummel MF, Davis MM
• Thirty-six views of T-cell recognition.
  Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000 Krummel M, Wülfing C, Sumen C, Davis MM
• Differential clustering of CD4 and CD3zeta during T cell recognition.
  Science (New York, N.Y.) 2000 Krummel MF, Sjaastad MD, Wülfing C, Davis MM
• Differential coupling of second signals for cytotoxicity and proliferation in CD8+ T cell effectors: amplification of the lytic potential by B7.
  Journal of immunology (Baltimore, Md. : 1950) 1999 Krummel MF, Heath WR, Allison J
• Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells.
  Nature 1999 Kurts C, Carbone FR, Krummel MF, Koch KM, Miller JF, Heath WR
• Visualizing T-cell recognition.
  Cold Spring Harbor symposia on quantitative biology 1999 Davis MM, Wülfing C, Krummel MF, Savage PA, Xu J, Sumen C, Dustin ML, Chien YH
• The threshold for autoimmune T cell killing is influenced by B7-1.
  European journal of immunology 1998 Allison J, Stephens LA, Kay TW, Kurts C, Heath WR, Miller JF, Krummel MF
• A role for CTLA-4-mediated inhibitory signals in peripheral T cell tolerance?
  Novartis Foundation symposium 1998 Allison JP, Chambers C, Hurwitz A, Sullivan T, Boitel B, Fournier S, Brunner M, Krummel M
• The nature of the signals regulating CD8 T cell proliferative responses to CD8alpha+ or CD8alpha- dendritic cells.
  European journal of immunology 1997 Winkel KD, Kronin V, Krummel MF, Shortman K
• Specific blockade of CTLA-4/B7 interactions results in exacerbated clinical and histologic disease in an actively-induced model of experimental allergic encephalomyelitis.
  Journal of neuroimmunology 1997 Hurwitz AA, Sullivan TJ, Krummel MF, Sobel RA, Allison JP
• The role of CTLA-4 in the regulation and initiation of T-cell responses.
  Immunological reviews 1996 Chambers CA, Krummel MF, Boitel B, Hurwitz A, Sullivan TJ, Fournier S, Cassell D, Brunner M, Allison JP
• CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.
  The Journal of experimental medicine 1996 Krummel MF, Allison JP
• Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo.
  International immunology 1996 Krummel MF, Sullivan TJ, Allison JP
• Enhancement of antitumor immunity by CTLA-4 blockade.
  Science (New York, N.Y.) 1996 Leach DR, Krummel MF, Allison JP
• The Yin and Yang of T cell costimulation.
  Science (New York, N.Y.) 1995 Allison JP, Krummel MF
• CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
  The Journal of experimental medicine 1995 Krummel MF, Allison JP