Matthieu Legrand, MD, PhD
Professor
Anesthesia
School of Medicine

He cares for severely ill patients, including patients with sepsis, after major surgery or any life-threatening condition with the ultimate goal of improving global outcomes and limiting both the short and long-term consequences of critical illnesses. Dr. Legrand completed his postgraduate training in Anesthesiology and Critical Care from 2003 to 2010 at Pierre and Marie Curie University in Paris, France, receiving his medical degree in 2010. Thereafter, he received a Ph.D. degree in Cardiovascular Physiology from Sorbonne Paris Cite University in 2012. Upon obtaining his medical degree, he was appointed as an Assistant Professor at the Paris Diderot University and was promoted associate to Full Professor of Anesthesiology and Critical Care Medicine in 2017. He also served as the Medical Director of Burn and surgical Intensive Care Units at Saint-Louis Hospital. He is now Professor and director of Clinical research in the department of Anesthesiology and Perioperative medicine of the University of California San Francisco.

• Biomarkers in acute kidney injury.
  Annals of intensive care 2024 Ostermann M, Legrand M, Meersch M, Srisawat N, Zarbock A, Kellum JA
• Decision-making in Perioperative Oliguria: Reply.
  Anesthesiology 2024 Legrand M, McCoy IE, Tallarico RT
• Major adverse kidney events as an endpoint in acute kidney injury trials: is it time for a RE-MAKE?
  Intensive care medicine 2024 Fuhrman DY, Bagshaw SM, Goldstein SL, Legrand M, Shaw AD
• Galectin-3 and Soluble CD146 Identify Cardiorenal Injuries in Severe Burn Patients: A Biomarker-Based Approach.
  Cardiorenal medicine 2024 Boutin L, Soussi S, Garcia Lavello A, Masson Fron E, Deniau B, Legrand M, Blot-Chabaud M, Figueroa SM, Chadjichristos CE, Azibani F, Dépret F
• Recommendations for clinical trial design in acute kidney injury from the 31st acute disease quality initiative consensus conference. A consensus statement.
  Intensive care medicine 2024 Zarbock A, Forni LG, Koyner JL, Bell S, Reis T, Meersch M, Bagshaw SM, Fuhmann DY, Liu KD, Pannu N, Arikan AA, Angus DC, Duquette D, Goldstein SL, Hoste E, Joannidis M, Jongs N, Legrand M, Mehta RL, …
• Low-Dose Corticosteroids for Critically Ill Adults With Severe Pulmonary Infections: A Review.
  JAMA 2024 Pirracchio R, Venkatesh B, Legrand M
• Intraoperative blood pressure management during kidney transplantation: Grafts under pressure.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2024 Adelmann D, Legrand M
• Incidence of acute kidney injury and attributive mortality in acute respiratory distress syndrome randomized trials.
  Intensive care medicine 2024 Antonucci E, Garcia B, Chen D, Matthay MA, Liu KD, Legrand M
• Hemodynamic Support in Sepsis.
  Anesthesiology 2024 Antonucci E, Garcia B, Legrand M
• Correction: Mild increases in plasma creatinine after intermediate to high-risk abdominal surgery are associated with long-term renal injury.
  BMC anesthesiology 2024 Joosten A, Ickx B, Mokhtari Z, Van Obbergh L, Lucidi V, Collange V, Naili S, Ichai P, Samuel D, Sa Cunha A, Alexander B, Legrand M, Taccone FS, Harrois A, Duranteau J, Vincent JL, Rinehart J, Van der …
• Using diuretic therapy in the critically ill patient.
  Intensive care medicine 2024 Ostermann M, Awdishu L, Legrand M
• Serial lactate measurements to guide resuscitation: more evidence not to?
  Intensive care medicine 2024 Legrand M, van der Horst ICC, De Jong A
• One-Year Survival and Hospital-free Days in Critical Illness After Viral Pneumonia.
  American journal of respiratory and critical care medicine 2024 Atramont A, Martin GL, Singer M, Tajahmady A, Agamaliyev E, Harhay MO, Leone M, Legrand M
• Should renin-angiotensin system inhibitors be held prior to major surgery?
  British journal of anaesthesia 2024 Legrand M
• Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials.
  Critical care (London, England) 2024 Legrand M, Bagshaw SM, Bhatraju PK, Bihorac A, Caniglia E, Khanna AK, Kellum JA, Koyner J, Harhay MO, Zampieri FG, Zarbock A, Chung K, Liu K, Mehta R, Pickkers P, Ryan A, Bernholz J, Dember L, …
• Meaning and Management of Perioperative Oliguria.
  Anesthesiology 2024 Tallarico RT, McCoy IE, Dépret F, Legrand M
• Association between peripheral perfusion index and postoperative acute kidney injury in major noncardiac surgery patients receiving continuous vasopressors: a post hoc exploratory analysis of the VEGA-1 trial.
  British journal of anaesthesia 2024 Krone S, Bokoch MP, Kothari R, Fong N, Tallarico RT, Sturgess-DaPrato J, Pirracchio R, Zarbock A, Legrand M
• Position Paper on the Reporting of Norepinephrine Formulations in Critical Care from the Society of Critical Care Medicine and European Society of Intensive Care Medicine Joint Task Force.
  Critical care medicine 2024 Wieruszewski PM, Leone M, Kaas-Hansen BS, Dugar S, Legrand M, McKenzie CA, Bissell Turpin BD, Messina A, Nasa P, Schorr CA, De Waele JJ, Khanna AK
• Postoperative thrombotic events following major surgery in patients with a history of COVID-19: a retrospective cohort analysis of commercially insured beneficiaries in the USA.
  Canadian journal of anaesthesia = Journal canadien d'anesthesie 2023 Lazzareschi DV, Luo Y, Fong N, Boscardin J, Legrand M, Chen CL
• The Need for Change in Generating Evidence for the Critically Ill.
  American journal of respiratory and critical care medicine 2023 Legrand M, Pletcher MJ, Kim SYH
• An international RAND/UCLA expert panel to determine the optimal diagnosis and management of burn inhalation injury.
  Critical care (London, England) 2023 Milton-Jones H, Soussi S, Davies R, Charbonney E, Charles WN, Cleland H, Dunn K, Gantner D, Giles J, Jeschke M, Lee N, Legrand M, Lloyd J, Martin-Loeches I, Pantet O, Samaan M, Shelley O, Sisson A, …
• The alternative renin-angiotensin system in critically ill patients: pathophysiology and therapeutic implications.
  Critical care (London, England) 2023 Garcia B, Zarbock A, Bellomo R, Legrand M
• Angiotensin II in liver transplantation (AngLT-1): protocol of a randomised, double-blind, placebo-controlled trial.
  BMJ open 2023 Bokoch MP, Tran AT, Brinson EL, Marcus SG, Reddy M, Sun E, Roll GR, Pardo M, Fields S, Adelmann D, Kothari RP, Legrand M
• Ketamine restriction correlates with reduced cholestatic liver injury and improved outcomes in critically ill patients with burn injury.
  JHEP reports : innovation in hepatology 2023 De Tymowski C, Dépret F, Dudoignon E, Moreno N, Zagdanski AM, Hodjat K, Deniau B, Mebazaa A, Legrand M, Mallet V, Keta-Cov research group
• Acute kidney injury in patients with burns.
  Nature reviews. Nephrology 2023 Legrand M, Clark AT, Neyra JA, Ostermann M
• The role of renin-angiotensin system in sepsis-associated acute kidney injury: mechanisms and therapeutic implications.
  Current opinion in critical care 2023 Garcia B, Zarbock A, Bellomo R, Legrand M
• Subclinical and clinical acute kidney injury share similar urinary peptide signatures and prognosis.
  Intensive care medicine 2023 Boutin L, Latosinska A, Mischak H, Deniau B, Asakage A, Legrand M, Gayat E, Mebazaa A, Chadjichristos CE, Depret F
• Impact of Vasodilator Administration on Survival in Patients with Sepsis: A Systematic Review and Meta-Analysis.
  Annals of the American Thoracic Society 2023 Mavrothalassitis OY, Allen IE, Lazzareschi DV, Tahir P, Legrand M
• Tackling sepsis-associated acute kidney injury using routinely collected data.
  Intensive care medicine 2023 Claure-Del Granado R, James MT, Legrand M
• Breaking Down the Evidence: Does Perioperative Hypotension Cause Kidney Injury?
  Nephron 2023 Antonucci E, Prado VE, Legrand M
• Adjunctive vasopressors in distributive shock: How soon is early?
  Critical care (London, England) 2023 Garcia B, Legrand M
• Leveraging observational data to identify targeted patient populations for future randomized trials.
  Research square 2023 Lazzareschi DV, Fong N, Pirracchio R, Mathis MR, Legrand M
• Intraoperative hypotension is bad but could the treatment be even worse?
  Anaesthesia, critical care & pain medicine 2023 Leone M, Joosten A, Legrand M
• Overcoming barriers in the design and implementation of clinical trials for acute kidney injury: a report from the 2020 Kidney Disease Clinical Trialists meeting.
  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2023 Lazzareschi D, Mehta RL, Dember LM, Bernholz J, Turan A, Sharma A, Kheterpal S, Parikh CR, Ali O, Schulman IH, Ryan A, Feng J, Simon N, Pirracchio R, Rossignol P, Legrand M
• Norepinephrine versus phenylephrine for treating hypotension during general anaesthesia in adult patients undergoing major noncardiac surgery: a multicentre, open-label, cluster-randomised, crossover, feasibility, and pilot trial.
  British journal of anaesthesia 2023 Legrand M, Kothari R, Fong N, Palaniappa N, Boldt D, Chen LL, Kurien P, Gabel E, Sturgess-DaPrato J, Harhay MO, Pirracchio R, Bokoch MP, VEGA-1 trial investigators
• All intraoperative hypotension is not created equal - A call for an individualized approach.
  Journal of clinical anesthesia 2023 Khanna AK, Zarbock A, Legrand M
• Intraoperative Use of Albumin in Major Noncardiac Surgery: Incidence, Variability, and Association With Outcomes.
  Annals of surgery 2022 Lazzareschi DV, Fong N, Mavrothalassitis O, Whitlock EL, Chen CL, Chiu C, Adelmann D, Bokoch MP, Chen LL, Liu KD, Pirracchio R, Mathis MR, Legrand M, MPOG Collaborators
• Letter to the editor: "Characterising acute kidney injury: The complementary roles of biomarkers of renal stress and renal function".
  Journal of critical care 2022 Legrand M, Gayat E
• Days Spent at Home and Mortality After Critical Illness: A Cluster Analysis Using Nationwide Data.
  Chest 2022 Martin GL, Atramont A, Mazars M, Tajahmady A, Agamaliyev E, Singer M, Leone M, Legrand M
• Pragmatic platform trials to improve the outcome of patients with acute kidney injury.
  Current opinion in critical care 2022 Tallarico RT, Neto AS, Legrand M
• Capillary refill time for the management of acute circulatory failure: a survey among pediatric and adult intensivists.
  BMC emergency medicine 2022 Jacquet-Lagrèze M, Wiart C, Schweizer R, Didier L, Ruste M, Coutrot M, Legrand M, Baudin F, Javouhey E, Dépret F, Fellahi JL
• Could Repeated Cardio-Renal Injury Trigger Late Cardiovascular Sequelae in Extreme Endurance Athletes?
  Sports medicine (Auckland, N.Z.) 2022 Burtscher J, Vanderriele PE, Legrand M, Predel HG, Niebauer J, O'Keefe JH, Millet GP, Burtscher M
• Optimizing the Design and Analysis of Future AKI Trials.
  Journal of the American Society of Nephrology : JASN 2022 Legrand M, Bagshaw SM, Koyner JL, Schulman IH, Mathis MR, Bernholz J, Coca S, Gallagher M, Gaudry S, Liu KD, Mehta RL, Pirracchio R, Ryan A, Steubl D, Stockbridge N, Erlandsson F, Turan A, Wilson FP, …
• Differences in HADS and SF-36 scores 1 year after critical illness in COVID-19 patients.
  Intensive care medicine 2022 Tallarico RT, Deniau B, Fong N, Ghosn J, Legrand M, French-COVID and the FROG-ICU Investigators
• Correction to: Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial.
  Intensive care medicine 2022 Bouglé A, Tuffet S, Federici L, Leone M, Monsel A, Dessalle T, Amour J, Dahyot-Fizelier C, Barbier F, Luyt CE, Langeron O, Cholley B, Pottecher J, Hissem T, Lefrant JY, Veber B, Legrand M, Demoule A, …
• Risk factors of long term symptoms and outcomes among patients discharged after covid-19: prospective, multicentre observational study.
  BMJ medicine 2022 Legrand M, Fong N, Laouénan C, Ghosn J, Thill B, Faure K, Garot D, Goujard C, Curlier E, Resche-Rigon M, Rossignol P, Pirracchio R
• Fluids, vasopressors, and acute kidney injury after major abdominal surgery between 2015 and 2019: a multicentre retrospective analysis.
  British journal of anaesthesia 2022 Chiu C, Fong N, Lazzareschi D, Mavrothalassitis O, Kothari R, Chen LL, Pirracchio R, Kheterpal S, Domino KB, Mathis M, Legrand M
• Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial.
  Intensive care medicine 2022 Bouglé A, Tuffet S, Federici L, Leone M, Monsel A, Dessalle T, Amour J, Dahyot-Fizelier C, Barbier F, Luyt CE, Langeron O, Cholley B, Pottecher J, Hissem T, Lefrant JY, Veber B, Legrand M, Demoule A, …
• Ten tips to optimize vasopressors use in the critically ill patient with hypotension.
  Intensive care medicine 2022 Legrand M, Zarbock A
• Peace, not war in Ukraine or anywhere else, please.
  Anaesthesia, critical care & pain medicine 2022 Lefrant JY, Pirracchio R, Benhamou D, Fischer MO, Njeim R, Allaouchiche B, Bastide S, Biais M, Bouvet L, Brissaud O, Brull SJ, Capdevila X, Clausen N, Cuvillon P, Dadure C, David JS, Du B, Einav S, …
• Digital health and artificial intelligence in kidney research: a report from the 2020 Kidney Disease Clinical Trialists (KDCT) meeting.
  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2022 Yi TW, Laing C, Kretzler M, Nkulikiyinka R, Legrand M, Jardine M, Rossignol P, Smyth B
• Galectin-3 in Kidney Diseases: From an Old Protein to a New Therapeutic Target.
  International journal of molecular sciences 2022 Boutin L, Dépret F, Gayat E, Legrand M, Chadjichristos CE
• Performance of renal Doppler to predict the occurrence of acute kidney injury in patients without acute kidney injury at admission.
  Journal of critical care 2022 Schnell D, Bourmaud A, Reynaud M, Rouleau S, Merdji H, Boivin A, Benyamina M, Vincent F, Lautrette A, Leroy C, Cohen Y, Legrand M, Morel J, Terreaux J, Darmon M
• Usefulness of lactate albumin ratio at admission to predict 28-day mortality in critically ill severely burned patients: A retrospective cohort study.
  Burns : journal of the International Society for Burn Injuries 2022 Dudoignon E, Quennesson T, De Tymowski C, Moreno N, Coutrot M, Chaussard M, Guillemet L, Abid S, Fratani A, Ressaire Q, Cupaciu A, Weinmann V, Pharaboz A, Benyamina M, Mebazaa A, Legrand M, Depret F, …
• Ventilation practices in burn patients-an international prospective observational cohort study.
  Burns & trauma 2021 Schultz MJ, Horn J, Hollmann MW, Preckel B, Glas GJ, Colpaert K, Malbrain M, Neto AS, Asehnoune K, de Abreu MG, Martin-Loeches I, Pelosi P, Sjöberg F, Binnekade JM, Cleffken B, Juffermans NP, Knape P,…
• Further evidence in support of closed ICUs.
  Anaesthesia, critical care & pain medicine 2021 Legrand M, Aldrich M
• 2021 adaptation of the editorial policy of Anaesthesia Critical Care and Pain Medicine (ACCPM).
  Anaesthesia, critical care & pain medicine 2021 Lefrant JY, Pirracchio R, Benhamou D, Njeim R, Ausset S, Bastide S, Biais M, Bouvet L, Brissaud O, Brull SJ, Capdevila X, Cuvillon P, Dadure C, David JS, Bin D, Fischer MO, Forget P, Fujii T, Godier A…
• Outcome of surgical patients during the first wave of the COVID-19 pandemic in US hospitals.
  British journal of anaesthesia 2021 Mavrothalassitis O, Pirracchio R, Fong N, Lazzareschi D, Sharma A, Vaughn MT, Mathis M, Legrand M
• Characteristics and prognosis of Herpesviridae-related pneumonia in critically ill burn patients.
  Burns : journal of the International Society for Burn Injuries 2021 Dépret F, Riaud C, Rouaux J, Chaussard M, Fratani A, Cupaciu A, Coutrot M, Guillemet L, Oueslati H, Benyamina M, Mebazaa A, Lafaurie M, Serror K, Chaouat M, Salmona M, Legoff J, Legrand M
• Ketamine-induced cholangiopathy in ARDS patients.
  Intensive care medicine 2021 de Tymowski C, Dépret F, Dudoignon E, Legrand M, Mallet V, Keta-Cov Research Group
• Kidney Replacement Therapy in the ICU: Less Is More (Death)?
  American journal of kidney diseases : the official journal of the National Kidney Foundation 2021 Legrand M, Liu KD
• Pathophysiology of COVID-19-associated acute kidney injury.
  Nature reviews. Nephrology 2021 Legrand M, Bell S, Forni L, Joannidis M, Koyner JL, Liu K, Cantaluppi V
• Acute kidney injury in the critically ill: an updated review on pathophysiology and management.
  Intensive care medicine 2021 Pickkers P, Darmon M, Hoste E, Joannidis M, Legrand M, Ostermann M, Prowle JR, Schneider A, Schetz M
• Goal-directed Therapy and Postcystectomy Ileus: Comment.
  Anesthesiology 2021 Joosten A, Alexander B, Legrand M, Duranteau J
• The Yin and Yang of the Renin-Angiotensin-Aldosterone System in Acute Kidney Injury.
  American journal of respiratory and critical care medicine 2021 Legrand M, Bokoch MP
• Mild increases in plasma creatinine after intermediate to high-risk abdominal surgery are associated with long-term renal injury.
  BMC anesthesiology 2021 Joosten A, Ickx B, Mokhtari Z, Van Obbergh L, Lucidi V, Collange V, Naili S, Ichai P, Samuel D, Sa Cunha A, Alexander B, Legrand M, Taccone FS, Harrois A, Duranteau J, Vincent JL, Rinehart J, Van der …
• Outcome of acute kidney injury: how to make a difference?
  Annals of intensive care 2021 Jamme M, Legrand M, Geri G
• Epidemiology of sepsis and septic shock.
  Current opinion in anaesthesiology 2021 Chiu C, Legrand M
• Anticoagulation strategies in continuous renal replacement therapy.
  Seminars in dialysis 2021 Legrand M, Tolwani A
• Severe Altered Immune Status After Burn Injury Is Associated With Bacterial Infection and Septic Shock.
  Frontiers in immunology 2021 Moins-Teisserenc H, Cordeiro DJ, Audigier V, Ressaire Q, Benyamina M, Lambert J, Maki G, Homyrda L, Toubert A, Legrand M
• Catecholaminergic Vasopressors Reduce Toll-Like Receptor Agonist-Induced Microvascular Endothelial Cell Permeability But Not Cytokine Production.
  Critical care medicine 2021 Joffre J, Lloyd E, Wong E, Chung-Yeh C, Nguyen N, Xu F, Legrand M, Hellman J
• Complications in Patients With COVID-19.
  JAMA cardiology 2021 Legrand M
• Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study.
  Critical care (London, England) 2021 Blet A, Deniau B, Santos K, van Lier DPT, Azibani F, Wittebole X, Chousterman BG, Gayat E, Hartmann O, Struck J, Bergmann A, Antonelli M, Beishuizen A, Constantin JM, Damoisel C, Deye N, Di Somma S, …
• Assessing the importance of interleukin-6 in COVID-19 - Authors' reply.
  The Lancet. Respiratory medicine 2021 Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, Hirayama AV, Mastroianni F, Turtle CJ, Harhay MO, Legrand M, Deutschman CS
• Microcirculation-targeted resuscitation in septic shock: can complex problems have simple answers?
  Annals of intensive care 2021 Joffre J, Legrand M
• Goal-directed therapy and development of acute kidney injury.
  European journal of anaesthesiology 2021 Joosten A, Alexander B, Duranteau J, Legrand M
• Angiotensin-Converting Enzyme Inhibitors and or Receptor Blockers After Acute Kidney Injury: Rehabilitation of the Supervillains.
  Critical care medicine 2020 Legrand M, Liu K
• Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup.
  Nature reviews. Nephrology 2020 Nadim MK, Forni LG, Mehta RL, Connor MJ, Liu KD, Ostermann M, Rimmelé T, Zarbock A, Bell S, Bihorac A, Cantaluppi V, Hoste E, Husain-Syed F, Germain MJ, Goldstein SL, Gupta S, Joannidis M, Kashani K, …
• The A2B trial, antibiotic prophylaxis for excision-graft surgery in burn patients: a multicenter randomized double-blind study.
  Trials 2020 Dépret F, Farny B, Jeanne M, Klouche K, Leclerc T, Nouette-Gaulain K, Pantet O, Rémerand F, Roquilly A, Rousseau AF, Sztajnic S, Wiramus S, Vicaut E, Legrand M, A2B trial investigators
• Choice of fluid for critically ill patients: An overview of specific situations.
  Anaesthesia, critical care & pain medicine 2020 Joannes-Boyau O, Roquilly A, Constantin JM, Duracher-Gout C, Dahyot-Fizelier C, Langeron O, Legrand M, Mirek S, Mongardon N, Mrozek S, Muller L, Orban JC, Virat A, Leone M, Critical Care Committee of …
• Response of US hospitals to elective surgical cases in the COVID-19 pandemic.
  British journal of anaesthesia 2020 Pirracchio R, Mavrothalassitis O, Mathis M, Kheterpal S, Legrand M
• Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes.
  The Lancet. Respiratory medicine 2020 Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, Hirayama AV, Mastroiani F, Turtle CJ, Harhay MO, Legrand M, Deutschman CS
• COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup.
  Nature reviews. Nephrology 2020 Nadim MK, Forni LG, Mehta RL, Connor MJ, Liu KD, Ostermann M, Rimmelé T, Zarbock A, Bell S, Bihorac A, Cantaluppi V, Hoste E, Husain-Syed F, Germain MJ, Goldstein SL, Gupta S, Joannidis M, Kashani K, …
• Incidence and Outcome of Subclinical Acute Kidney Injury Using penKid in Critically Ill Patients.
  American journal of respiratory and critical care medicine 2020 Dépret F, Hollinger A, Cariou A, Deye N, Vieillard-Baron A, Fournier MC, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Darmon M, Leone M, Guidet B, Sonneville R, Montravers P, Pili-Floury S, Lefrant…
• Cardiovascular Consequences of Acute Kidney Injury. Reply.
  The New England journal of medicine 2020 Legrand M, Rossignol P
• Insulin glucose infusion versus nebulised salbutamol versus combination of salbutamol and insulin glucose in acute hyperkalaemia in the emergency room: protocol for a randomised, multicentre, controlled study (INSAKA).
  BMJ open 2020 Montassier E, Lemoine L, Hardouin JB, Rossignol P, Legrand M
• Hypokalemia is frequent and has prognostic implications in stable patients attending the emergency department.
  PloS one 2020 Abensur Vuillaume L, Ferreira JP, Asseray N, Trombert-Paviot B, Montassier E, Legrand M, Girerd N, Boivin JM, Chouihed T, Rossignol P
• Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury.
  Nephron 2020 Khorashadi M, Beunders R, Pickkers P, Legrand M
• Management and prevention of anemia (acute bleeding excluded) in adult critical care patients.
  Anaesthesia, critical care & pain medicine 2020 Lasocki S, Pène F, Ait-Oufella H, Aubron C, Ausset S, Buffet P, Huet O, Launey Y, Legrand M, Lescot T, Mekontso Dessap A, Piagnerelli M, Quintard H, Velly L, Kimmoun A, Chanques G
• Management and prevention of anemia (acute bleeding excluded) in adult critical care patients.
  Annals of intensive care 2020 Lasocki S, Pène F, Ait-Oufella H, Aubron C, Ausset S, Buffet P, Huet O, Launey Y, Legrand M, Lescot T, Mekontso Dessap A, Piagnerelli M, Quintard H, Velly L, Kimmoun A, Chanques G
• Practical management of worsening renal function in outpatients with heart failure and reduced ejection fraction: Statement from a panel of multidisciplinary experts and the Heart Failure Working Group of the French Society of Cardiology.
  Archives of cardiovascular diseases 2020 Mewton N, Girerd N, Boffa JJ, Courivaud C, Isnard R, Juillard L, Lamblin N, Legrand M, Logeart D, Mariat C, Meune E, Sabouret P, Sebbag L, Rossignol P
• The I-MICRO trial, Ilomedin for treatment of septic shock with persistent microperfusion defects: a double-blind, randomized controlled trial-study protocol for a randomized controlled trial.
  Trials 2020 Legrand M, Oufella HA, De Backer D, Duranteau J, Leone M, Levy B, Rossignol P, Vicaut E, Dépret F, I-MICRO trial investigators
• Activation of the renin-angiotensin-aldosterone system is associated with Acute Kidney Injury in COVID-19.
  Anaesthesia, critical care & pain medicine 2020 Dudoignon E, Moreno N, Deniau B, Coutrot M, Longer R, Amiot Q, Mebazaa A, Pirracchio R, Depret F, Legrand M
• Cardiovascular Consequences of Acute Kidney Injury.
  The New England journal of medicine 2020 Legrand M, Rossignol P
• Sepsis and Septic Shock in Patients With Malignancies: A Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique Study.
  Critical care medicine 2020 Lemiale V, Pons S, Mirouse A, Tudesq JJ, Hourmant Y, Mokart D, Pène F, Kouatchet A, Mayaux J, Nyunga M, Bruneel F, Meert AP, Borcoman E, Bisbal M, Legrand M, Benoit D, Azoulay E, Darmon M, Zafrani L
• Outcome and characteristics of invasive fungal infections in critically ill burn patients: A multicenter retrospective study.
  Mycoses 2020 Maurel V, Denis B, Camby M, Jeanne M, Cornesse A, Glavnik B, Alanio A, Rousseau AF, Lefloch R, Lagrange-Xelot M, Textoris J, Wiramus S, de Tymowski C, Legrand M
• Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury.
  Journal of immunology (Baltimore, Md. : 1950) 2020 Joffre J, Yeh CC, Wong E, Thete M, Xu F, Zlatanova I, Lloyd E, Kobzik L, Legrand M, Hellman J
• Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation.
  Intensive care medicine 2020 Leisman DE, Deutschman CS, Legrand M
• Circulating dipeptidyl peptidase-3 at admission is associated with circulatory failure, acute kidney injury and death in severely ill burn patients.
  Critical care (London, England) 2020 Dépret F, Amzallag J, Pollina A, Fayolle-Pivot L, Coutrot M, Chaussard M, Santos K, Hartmann O, Jully M, Fratani A, Oueslati H, Cupaciu A, Benyamina M, Guillemet L, Deniau B, Mebazaa A, Gayat E, Farny…
• Point-of-care serum kalemia measurement accuracy.
  European journal of emergency medicine : official journal of the European Society for Emergency Medicine 2020 Depret F, Bonnart Latry D, Gayat E, Plaisance P, Legrand M
• Sedation with remifentanil or propofol for flexible bronchoscopy: A randomised controlled trial.
  European journal of anaesthesiology 2020 Maurel V, Legrand M, Bourgeois E, Masse AL, Bergeron A, Binakdane F, Ntahe A, Legouge M, Vicaut E, Plaud B
• Should we ban hydroethyl starches from the operating theatre? PRO.
  Anaesthesia, critical care & pain medicine 2020 Legrand M, Pirracchio R
• Management of severe thermal burns in the acute phase in adults and children.
  Anaesthesia, critical care & pain medicine 2020 Legrand M, Barraud D, Constant I, Devauchelle P, Donat N, Fontaine M, Goffinet L, Hoffmann C, Jeanne M, Jonqueres J, Leclerc T, Lefort H, Louvet N, Losser MR, Lucas C, Pantet O, Roquilly A, Rousseau …
• Utility of anaerobic bottles for the diagnosis of bloodstream infections.
  BMC infectious diseases 2020 Lafaurie M, d'Anglejan E, Donay JL, Glotz D, Sarfati E, Mimoun M, Legrand M, Oksenhendler E, Bagot M, Valade S, Bercot B, Molina JM
• Is nitric oxide the forgotten nephroprotective treatment during cardiac surgery?
  Annals of intensive care 2020 Khorashadi M, Bokoch MP, Legrand M
• Physiological response to fluid resuscitation with Ringer lactate versus Plasmalyte in critically ill burn patients.
  Journal of applied physiology (Bethesda, Md. : 1985) 2020 Chaussard M, Dépret F, Saint-Aubin O, Benyamina M, Coutrot M, Jully M, Oueslati H, Fratani A, Cupaciu A, Poniard A, Asehnoune K, Dimby SF, Mebazaa A, Houze P, Legrand M
• Perioperative maintenance fluid therapy in patients undergoing thoracic surgery: more risks than benefits?
  Intensive care medicine 2020 Legrand M, Alexander B, Joosten A
• PenKid measurement at admission is associated with outcome in severely ill burn patients.
  Burns : journal of the International Society for Burn Injuries 2020 Dépret F, Polina A, Amzallag J, Fayolle-Pivot L, Coutrot M, Chaussard M, Struck J, Hartmann O, Jully M, Fratani A, Oueslati H, Cupaciu A, Soussi S, Benyamina M, Guillemet L, Mebazaa A, Textoris J, …
• Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury.
  Cardiorenal medicine 2020 Parenica J, Kala P, Mebazaa A, Littnerova S, Benesova K, Tomandl J, Goldbergová Pavkova M, Jarkovský J, Spinar J, Tomandlova M, Dastych M, Ince C, Helanova K, Tesak M, Helan M, Lokaj P, Legrand M, …
• Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study.
  Critical care (London, England) 2019 Dépret F, Hoffmann C, Daoud L, Thieffry C, Monplaisir L, Creveaux J, Annane D, Parmentier E, Mathieu D, Wiramus S, Demeure DIt Latte D, Kpodji A, Textoris J, Robin F, Klouche K, Pontis E, Schnell G, …
• Report of the first AKI Round Table meeting: an initiative of the ESICM AKI Section.
  Intensive care medicine experimental 2019 Ostermann M, Schneider A, Rimmele T, Bobek I, van Dam M, Darmon M, Forni L, Joannes-Boyau O, Joannidis M, Legrand M, Prowle J, Zarbock A, Hoste E
• One-Year Prognosis of Kidney Injury at Discharge From the ICU: A Multicenter Observational Study.
  Critical care medicine 2019 Legrand M, Hollinger A, Vieillard-Baron A, Dépret F, Cariou A, Deye N, Fournier MC, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Darmon M, Zafrani L, Leone M, Guidet B, Friedman D, Sonneville R, …
• Tailoring treatment of hyperkalemia.
  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2019 Coutrot M, Dépret F, Legrand M
• Untitled Publication
  Revue de l'infirmiere 2019 Lefort H, Legrand M
• The artificial kidney induces AKI? Not if we apply "kidney-protective" renal replacement therapy.
  Intensive care medicine 2019 Legrand M, Prowle JR, Forni LG
• Monitoring tissue perfusion: a pilot clinical feasibility and safety study of a urethral photoplethysmography-derived perfusion device in high-risk patients.
  Journal of clinical monitoring and computing 2019 Dépret F, Leone M, Duclos G, Futier E, Montagne M, Legrand M, Allaouchiche B
• Hemoadsorption efficacy for uncomplicated high-risk cardiac surgery.
  Critical care (London, England) 2019 Redant S, Legrand M, Langman Y, Aguilar AG, Angoulvant F, Kaefer K, De Bels D, Attou R, Kashani K, Honore PM
• Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway.
  JACC. Basic to translational science 2019 Prud'homme M, Coutrot M, Michel T, Boutin L, Genest M, Poirier F, Launay JM, Kane B, Kinugasa S, Prakoura N, Vandermeersch S, Cohen-Solal A, Delcayre C, Samuel JL, Mehta R, Gayat E, Mebazaa A, …
• Urgent need for a randomized controlled trial with only septic patients!
  Annals of intensive care 2019 Redant S, Legrand M, Langman Y, Garcia Aguilar A, Kaefer K, De Bels D, Attou R, Kashani K, Honore PM
• Early hypoalbuminemia is associated with 28-day mortality in severely burned patients: A retrospective cohort study.
  Burns : journal of the International Society for Burn Injuries 2019 de Tymowski C, Pallado S, Anstey J, Depret F, Moreno N, Benyamina M, Cupaciu A, Jully M, Oueslati H, Fratani A, Coutrot M, Chaussard M, Guillemet L, Dudoignon E, Mimoun M, Chaouat M, Mebazaa A, …
• Update in antibiotic therapy in intensive care unit: report from the 2019 Nîmes International Symposium.
  Anaesthesia, critical care & pain medicine 2019 Leone M, Roberts JA, Bassetti M, Bouglé A, Lavigne JP, Legrand M, Neely M, Paiva JA, Payen D, Rello J, Roger C, Sjövall F, Jung B
• Reply to: "Potential role of ketamine in burn-associated cholestasis".
  Journal of hepatology 2019 Legrand M, de Tymowski C, Hodjat K, Mallet V
• Correction to: Recruiting the microcirculation in septic shock.
  Annals of intensive care 2019 Legrand M, De Backer D, Dépret F, Ait-Oufella H
• Management of Burns.
  The New England journal of medicine 2019 Legrand M, Dépret F, Mallet V
• Recruiting the microcirculation in septic shock.
  Annals of intensive care 2019 Legrand M, De Backer D, Dépret F, Ait-Oufella H
• Homogeneous sulfur isotope signature in East Antarctica and implication for sulfur source shifts through the last glacial-interglacial cycle.
  Scientific reports 2019 Ishino S, Hattori S, Savarino J, Legrand M, Albalat E, Albarede F, Preunkert S, Jourdain B, Yoshida N
• Analysis of the medical response to November 2015 Paris terrorist attacks: resource utilization according to the cause of injury.
  Intensive care medicine 2019 Raux M, Carli P, Lapostolle F, Langlois M, Yordanov Y, Féral-Pierssens AL, Woloch A, Ogereau C, Gayat E, Attias A, Pateron D, Castier Y, François A, Ludes B, Dolla E, Tourtier JP, Riou B, TRAUMABASE …
• Understanding the renal response to brain injury.
  Intensive care medicine 2019 Legrand M, Sonneville R
• Hyperkalemia in the Emergency Department: Urgent Need for a Rigorous Evaluation of the First-Line Treatments.
  The Journal of emergency medicine 2019 Lemoine L, Chouihed T, Legrand M, Rossignol P, Potel G, Montassier E
• Long-term mortality and quality of life after trauma: an ancillary study from the prospective multicenter trial FROG-ICU.
  European journal of trauma and emergency surgery : official publication of the European Trauma Society 2019 Pastene B, Cinotti R, Gayat E, Duranteau J, Lu Q, Montravers P, Pili-Floury S, Rennuit I, Mebazaa A, Leone M, FROG-ICU investigators
• Is Nitric Oxide Nephro- or Cardioprotective?
  American journal of respiratory and critical care medicine 2019 Coutrot M, Dépret F, Legrand M
• Contributing factors and outcomes of burn-associated cholestasis.
  Journal of hepatology 2019 de Tymowski C, Dépret F, Soussi S, Nabila M, Vauchel T, Chaussard M, Benyamina M, Ferry A, Cupaciu A, Jully M, Oueslati H, Fratani A, Coutrot M, Sogni P, Mimoun M, Chaouat M, Zagdanski AM, De Kerviler…
• Acute Kidney Injury Related to Sepsis-Reply.
  JAMA 2019 Legrand M, Kellum JA
• Continuous infusion of ceftolozane/tazobactam is associated with a higher probability of target attainment in patients infected with Pseudomonas aeruginosa.
  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2019 Pilmis B, Petitjean G, Lesprit P, Lafaurie M, El Helali N, Le Monnier A, on behalf the ATB PK/PD study group
• Association of Age With Short-term and Long-term Mortality Among Patients Discharged From Intensive Care Units in France.
  JAMA network open 2019 Atramont A, Lindecker-Cournil V, Rudant J, Tajahmady A, Drewniak N, Fouard A, Singer M, Leone M, Legrand M
• Is the Renin-Angiotensin-Aldosterone System Good for the Kidney in Acute Settings?
  Nephron 2019 Dudoignon E, Dépret F, Legrand M
• Impact of renin-angiotensin system inhibitors continuation versus discontinuation on outcome after major surgery: protocol of a multicenter randomized, controlled trial (STOP-or-NOT trial).
  Trials 2019 Legrand M, Futier E, Leone M, Deniau B, Mebazaa A, Plaud B, Coriat P, Rossignol P, Vicaut E, Gayat E, STOP-OR-NOT study investigators
• Management of hyperkalemia in the acutely ill patient.
  Annals of intensive care 2019 Dépret F, Peacock WF, Liu KD, Rafique Z, Rossignol P, Legrand M
• Multicentre randomised controlled trial to investigate usefulness of the rapid diagnostic βLACTA test performed directly on bacterial cell pellets from respiratory, urinary or blood samples for the early de-escalation of carbapenems in septic intensive care unit patients: the BLUE-CarbA protocol.
  BMJ open 2019 Garnier M, Gallah S, Vimont S, Benzerara Y, Labbe V, Constant AL, Siami S, Guerot E, Compain F, Mainardi JL, Montil M, Quesnel C, BLUE-CarbA study group.
• Risk Factors for Acute Mesenteric Ischemia in Critically Ill Burns Patients-A Matched Case-Control Study.
  Shock (Augusta, Ga.) 2019 Soussi S, Taccori M, De Tymowski C, Depret F, Chaussard M, Fratani A, Jully M, Cupaciu A, Ferry A, Benyamina M, Serror K, Boccara D, Chaouat M, Mimoun M, Cattan P, Zagdanski AM, Anstey J, Mebazaa A, …
• Endogenous Retroviruses Transcriptional Modulation After Severe Infection, Trauma and Burn.
  Frontiers in immunology 2019 Tabone O, Mommert M, Jourdan C, Cerrato E, Legrand M, Lepape A, Allaouchiche B, Rimmelé T, Pachot A, Monneret G, Venet F, Mallet F, Textoris J
• Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study.
  Critical care (London, England) 2018 Mebazaa A, Geven C, Hollinger A, Wittebole X, Chousterman BG, Blet A, Gayat E, Hartmann O, Scigalla P, Struck J, Bergmann A, Antonelli M, Beishuizen A, Constantin JM, Damoisel C, Deye N, Di Somma S, …
• Outcome and potentially modifiable risk factors for candidemia in critically ill burns patients: A matched cohort study.
  Mycoses 2018 Dudoignon E, Alanio A, Anstey J, Depret F, Coutrot M, Fratani A, Jully M, Cupaciu A, Chaussard M, Oueslati H, Ferry A, Benyamina M, de Tymowski C, Boccara D, Serror K, Chaouat M, Mimoun M, Lafaurie M,…
• Serum Creatinine in the Critically Ill Patient With Sepsis.
  JAMA 2018 Legrand M, Kellum JA
• Incidence, risk factors and outcome of multi-drug resistant Acinetobacter baumannii nosocomial infections during an outbreak in a burn unit.
  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2018 Munier AL, Biard L, Legrand M, Rousseau C, Lafaurie M, Donay JL, Flicoteaux R, Mebazaa A, Mimoun M, Molina JM
• Impact of an Acinetobacter baumannii outbreak on kidney events in a burn unit: A targeted machine learning analysis.
  American journal of infection control 2018 Vauchel T, Pirracchio R, Chaussard M, Lafaurie M, Rouveau M, Rousseau C, Benyamina M, Soussi S, Dépret F, Ferry A, Oueslati H, Chaouat M, Mimoun M, Jarlier V, Moreno N, Mebazaa A, Legrand M
• Hydroxocobalamin as a Cause of Oxalate Nephropathy.
  Kidney international reports 2018 Legrand M
• French intensive care unit organisation.
  Anaesthesia, critical care & pain medicine 2018 Leone M, Constantin JM, Dahyot-Fizelier C, Duracher-Gout C, Joannes-Boyau O, Langeron O, Legrand M, Mahjoub Y, Mirek S, Mrozek S, Muller L, Orban JC, Quesnel C, Roquilly A, Virat A, Capdevila X
• CRRT and ECMO: Dialysis catheter or connection to the ECMO circuit?
  Anaesthesia, critical care & pain medicine 2018 Schetz M, Legrand M
• Hyperkalemia in the emergency department: Consider the use of nebulized salbutamol.
  The American journal of emergency medicine 2018 Montassier E, Legrand M, Rossignol P, Potel G
• Prediction of major adverse kidney events in critically ill burn patients.
  Burns : journal of the International Society for Burn Injuries 2018 Dépret F, Boutin L, Jarkovský J, Chaussard M, Soussi S, Bataille A, Oueslati H, Moreno N, de Tymowski C, Parenica J, Benešová K, Vauchel T, Ferry A, Benyamina M, Cupaciu A, Coutrot M, Garnier JP, …
• Performance of Doppler-based resistive index and semi-quantitative renal perfusion in predicting persistent AKI: results of a prospective multicenter study.
  Intensive care medicine 2018 Darmon M, Bourmaud A, Reynaud M, Rouleau S, Meziani F, Boivin A, Benyamina M, Vincent F, Lautrette A, Leroy C, Cohen Y, Legrand M, Morel J, Terreaux J, Schnell D
• Planned enteral nutrition over-prescription to cover caloric and protein requirements in severely-ill burn patients.
  Burns : journal of the International Society for Burn Injuries 2018 Grangé C, Dépret F, Oueslati H, Legrand M, Soussi S
• Negative trials in critical care medicine and the hurdles.
  The Lancet. Respiratory medicine 2018 Legrand M
• Early Hemodynamic Management of Critically Ill Burn Patients.
  Anesthesiology 2018 Soussi S, Dépret F, Benyamina M, Legrand M
• New-onset atrial fibrillation in critically ill patients and its association with mortality: A report from the FROG-ICU study.
  International journal of cardiology 2018 Arrigo M, Ishihara S, Feliot E, Rudiger A, Deye N, Cariou A, Guidet B, Jaber S, Leone M, Resche-Rigon M, Vieillard Baron A, Legrand M, Gayat E, Mebazaa A
• Methods used to assess the performance of biomarkers for the diagnosis of acute kidney injury: a systematic review and meta-analysis.
  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2018 Codorniu A, Lemasle L, Legrand M, Blet A, Mebazaa A, Gayat E
• Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study.
  Kidney international reports 2018 Hollinger A, Wittebole X, François B, Pickkers P, Antonelli M, Gayat E, Chousterman BG, Lascarrou JB, Dugernier T, Di Somma S, Struck J, Bergmann A, Beishuizen A, Constantin JM, Damoisel C, Deye N, …
• Hemodynamic management of critically ill burn patients: an international survey.
  Critical care (London, England) 2018 Soussi S, Berger MM, Colpaert K, Dünser MW, Guttormsen AB, Juffermans NP, Knape P, Koksal G, Lavrentieva A, Leclerc T, Lorente JA, Martin-Loeches I, Metnitz P, Pantet O, Pelosi P, Rousseau AF, Sjöberg…
• Determining the editorial policy of Anaesthesia Critical Care and Pain Medicine (ACCPM).
  Anaesthesia, critical care & pain medicine 2018 Lefrant JY, Lorne E, Asehnoune K, Ausset S, Beaulieu P, Biais M, Brichant JF, Charbit B, Constantin JM, Cuvillon P, Dadure C, Dahmani S, David JS, Fuchs-Buder T, Geeraerts T, Godier A, Hanouz JL, …
• Ongoing Development and Evaluation of a Method of Telemedicine: Burn Care Management With a Smartphone.
  Journal of burn care & research : official publication of the American Burn Association 2018 Boccara D, Bekara F, Soussi S, Legrand M, Chaouat M, Mimoun M, Serror K
• When ethics collides with a legal gap in emergency life-threatening conditions.
  British journal of anaesthesia 2018 Legrand M, Bastien O, Chaouat M, Mebazaa A, Séval F, Mimoun M, Vallet B
• Impact of angiotensin-converting enzyme inhibitors or receptor blockers on post-ICU discharge outcome in patients with acute kidney injury.
  Intensive care medicine 2018 Gayat E, Hollinger A, Cariou A, Deye N, Vieillard-Baron A, Jaber S, Chousterman BG, Lu Q, Laterre PF, Monnet X, Darmon M, Leone M, Guidet B, Sonneville R, Lefrant JY, Fournier MC, Resche-Rigon M, …
• Could resuscitation be based on microcirculation data? Yes.
  Intensive care medicine 2018 Legrand M, Ait-Oufella H, Ince C
• Outbreak of Invasive Wound Mucormycosis in a Burn Unit Due to Multiple Strains of Mucor circinelloides f. circinelloides Resolved by Whole-Genome Sequencing.
  mBio 2018 Garcia-Hermoso D, Criscuolo A, Lee SC, Legrand M, Chaouat M, Denis B, Lafaurie M, Rouveau M, Soler C, Schaal JV, Mimoun M, Mebazaa A, Heitman J, Dromer F, Brisse S, Bretagne S, Alanio A
• Cardiac output and CVP monitoring… to guide fluid removal.
  Critical care (London, England) 2018 Legrand M, Soussi S, Depret F
• Sevoflurane for procedural sedation in critically ill patients: A pharmacokinetic comparative study between burn and non-burn patients.
  Anaesthesia, critical care & pain medicine 2018 Perbet S, Bourdeaux D, Lenoire A, Biboulet C, Pereira B, Sadoune M, Plaud B, Launay JM, Bazin JE, Sautou V, Mebazaa A, Houze P, Constantin JM, Legrand M, PRONOBURN group
• Renal Replacement Therapy Modality in the ICU and Renal Recovery at Hospital Discharge.
  Critical care medicine 2018 Bonnassieux M, Duclos A, Schneider AG, Schmidt A, Bénard S, Cancalon C, Joannes-Boyau O, Ichai C, Constantin JM, Lefrant JY, Kellum JA, Rimmelé T, AzuRéa Group
• Tolvaptan in Later-Stage Polycystic Kidney Disease.
  The New England journal of medicine 2018 De Tymowski C, Legrand M
• Back-to-back comparison of penKID with NephroCheck® to predict acute kidney injury at admission in intensive care unit: a brief report.
  Critical care (London, England) 2018 Gayat E, Touchard C, Hollinger A, Vieillard-Baron A, Mebazaa A, Legrand M, FROG ICU study investigators
• Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study.
  Critical care (London, England) 2018 Gayat E, Cariou A, Deye N, Vieillard-Baron A, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Azoulay E, Léone M, Oueslati H, Guidet B, Friedman D, Tesnière A, Sonneville R, Montravers P, Pili-Floury …
• Measurement of Oxygen Consumption Variations in Critically Ill Burns Patients: Are the Fick Method and Indirect Calorimetry Interchangeable?
  Shock (Augusta, Ga.) 2017 Soussi S, Vallée F, Roquet F, Bevilacqua V, Benyamina M, Ferry A, Cupaciu A, Chaussard M, De Tymowski C, Boccara D, Mimoun M, Chaouat M, Anstey J, Mebazaa A, Legrand M, PRONOBURN study group
• Association between hypo- and hyperkalemia and outcome in acute heart failure patients: the role of medications.
  Clinical research in cardiology : official journal of the German Cardiac Society 2017 Legrand M, Ludes PO, Massy Z, Rossignol P, Parenica J, Park JJ, Ishihara S, AlHabib KF, Maggioni A, Miró Ò, Sato N, Cohen-Solal A, Fairman E, Lassus J, Harjola VP, Mueller C, Peacock FW, Choi DJ, …
• Burns caused by electronic vaping devices (e-cigarettes): A new classification proposal based on mechanisms.
  Burns : journal of the International Society for Burn Injuries 2017 Serror K, Chaouat M, Legrand MM, Depret F, Haddad J, Malca N, Mimoun M, Boccara D
• Pressure guided surgery of compartment syndrome of the limbs in burn patients.
  Annals of burns and fire disasters 2017 Boccara D, Lavocat R, Soussi S, Legrand M, Chaouat M, Mebazaa A, Mimoun M, Blet A, Serror K
• Undetectable haptoglobin is associated with major adverse kidney events in critically ill burn patients.
  Critical care (London, England) 2017 Dépret F, Dunyach C, De Tymowski C, Chaussard M, Bataille A, Ferry A, Moreno N, Cupaciu A, Soussi S, Benyamina M, Mebazaa A, Serror K, Chaouat M, Garnier JP, Pirracchio R, Legrand M, PRONOBURN group
• Intravenous iloprost to recruit the microcirculation in septic shock patients?
  Intensive care medicine 2017 Dépret F, Sitbon A, Soussi S, De Tymowski C, Blet A, Fratani A, Legrand M
• Intravenous hydroxocobalamin and crystal nephropathy.
  Nature reviews. Nephrology 2017 Legrand M, Mallet V
• Incidence, risk factors, and outcome of multidrug-resistant Acinetobacter baumannii acquisition during an outbreak in a burns unit.
  The Journal of hospital infection 2017 Munier AL, Biard L, Rousseau C, Legrand M, Lafaurie M, Lomont A, Donay JL, de Beaugrenier E, Flicoteaux R, Mebazaa A, Mimoun M, Molina JM
• On-line plasma lactate concentration monitoring in critically ill patients.
  Critical care (London, England) 2017 De Tymowski C, Soussi S, Depret F, Legrand M
• A Role of Remote Organs Effect in Acute Kidney Injury Outcome.
  Nephron 2017 Dépret F, Prud'homme M, Legrand M
• Are capillary and arterial lactates interchangeable?
  Anaesthesia, critical care & pain medicine 2017 Dépret F, Legrand M
• Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).
  European journal of heart failure 2017 Harjola VP, Mullens W, Banaszewski M, Bauersachs J, Brunner-La Rocca HP, Chioncel O, Collins SP, Doehner W, Filippatos GS, Flammer AJ, Fuhrmann V, Lainscak M, Lassus J, Legrand M, Masip J, Mueller C, …
• Imbalanced Angiogenesis in Peripartum Cardiomyopathy　- Diagnostic Value of Placenta Growth Factor.
  Circulation journal : official journal of the Japanese Circulation Society 2017 Mebazaa A, Seronde MF, Gayat E, Tibazarwa K, Anumba DOC, Akrout N, Sadoune M, Sarb J, Arrigo M, Motiejunaite J, Laribi S, Legrand M, Deschamps L, Fazal L, Bouadma L, Collet C, Manivet P, Solal AC, …
• A nephrologist should be consulted in all cases of acute kidney injury in the ICU: We are not sure.
  Intensive care medicine 2017 Schetz M, Legrand M
• Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference.
  Annals of intensive care 2017 Bellomo R, Ronco C, Mehta RL, Asfar P, Boisramé-Helms J, Darmon M, Diehl JL, Duranteau J, Hoste EAJ, Olivier JB, Legrand M, Lerolle N, Malbrain MLNG, Mårtensson J, Oudemans-van Straaten HM, Parienti …
• Diagnostic work-up and specific causes of acute kidney injury.
  Intensive care medicine 2017 Darmon M, Ostermann M, Cerda J, Dimopoulos MA, Forni L, Hoste E, Legrand M, Lerolle N, Rondeau E, Schneider A, Souweine B, Schetz M
• Infectious Complications and Immune/Inflammatory Response in Cardiogenic Shock Patients: A Prospective Observational Study.
  Shock (Augusta, Ga.) 2017 Parenica J, Jarkovsky J, Malaska J, Mebazaa A, Gottwaldova J, Helanova K, Litzman J, Dastych M, Tomandl J, Spinar J, Dostalova L, Lokaj P, Tomandlova M, Pavkova MG, Sevcik P, Legrand M, GREAT Network
• Empiric use of hydroxocobalamin in patients with smoke inhlation injury: Not so fast!
  Burns : journal of the International Society for Burn Injuries 2017 Legrand M, Michel T
• Hemodynamic coherence in patients with burns.
  Best practice & research. Clinical anaesthesiology 2016 Soussi S, Legrand M
• Not all β-lactams are equal regarding neurotoxicity.
  Critical care (London, England) 2016 Chaïbi K, Chaussard M, Soussi S, Lafaurie M, Legrand M
• Should we apply "early" initiation of renal replacement therapy to critically ill patients with acute kidney injury?
  Journal of thoracic disease 2016 Legrand M
• Emergency management of severe hyperkalemia: Guideline for best practice and opportunities for the future.
  Pharmacological research 2016 Rossignol P, Legrand M, Kosiborod M, Hollenberg SM, Peacock WF, Emmett M, Epstein M, Kovesdy CP, Yilmaz MB, Stough WG, Gayat E, Pitt B, Zannad F, Mebazaa A
• Management of neutropenic patients in the intensive care unit (NEWBORNS EXCLUDED) recommendations from an expert panel from the French Intensive Care Society (SRLF) with the French Group for Pediatric Intensive Care Emergencies (GFRUP), the French Society of Anesthesia and Intensive Care (SFAR), the French Society of Hematology (SFH), the French Society for Hospital Hygiene (SF2H), and the French Infectious Diseases Society (SPILF).
  Annals of intensive care 2016 Schnell D, Azoulay E, Benoit D, Clouzeau B, Demaret P, Ducassou S, Frange P, Lafaurie M, Legrand M, Meert AP, Mokart D, Naudin J, Pene F, Rabbat A, Raffoux E, Ribaud P, Richard JC, Vincent F, Zahar JR…
• Low cardiac index and stroke volume on admission are associated with poor outcome in critically ill burn patients: a retrospective cohort study.
  Annals of intensive care 2016 Soussi S, Deniau B, Ferry A, Levé C, Benyamina M, Maurel V, Chaussard M, Le Cam B, Blet A, Mimoun M, Lambert J, Chaouat M, Mebazaa A, Legrand M, PRONOBURN group
• Understanding the kidney during acute respiratory failure.
  Intensive care medicine 2016 Darmon M, Legrand M, Terzi N
• Detection of Circulating Mucorales DNA in Critically Ill Burn Patients: Preliminary Report of a Screening Strategy for Early Diagnosis and Treatment.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2016 Legrand M, Gits-Muselli M, Boutin L, Garcia-Hermoso D, Maurel V, Soussi S, Benyamina M, Ferry A, Chaussard M, Hamane S, Denis B, Touratier S, Guigue N, Fréalle E, Jeanne M, Shaal JV, Soler C, Mimoun M…
• Extracorporeal membrane oxygenation in burn patients with refractory acute respiratory distress syndrome leads to 28 % 90-day survival.
  Intensive care medicine 2016 Soussi S, Gallais P, Kachatryan L, Benyamina M, Ferry A, Cupaciu A, Chaussard M, Maurel V, Chaouat M, Mimoun M, Mebazza A, Legrand M, PRONOBURN Group
• Chloride toxicity in critically ill patients: What's the evidence?
  Anaesthesia, critical care & pain medicine 2016 Soussi S, Ferry A, Chaussard M, Legrand M
• Similar hemodynamic decongestion with vasodilators and inotropes: systematic review, meta-analysis, and meta-regression of 35 studies on acute heart failure.
  Clinical research in cardiology : official journal of the German Cardiac Society 2016 Ishihara S, Gayat E, Sato N, Arrigo M, Laribi S, Legrand M, Placido R, Manivet P, Cohen-Solal A, Abraham WT, Jessup M, Mebazaa A
• What's new in focused assessment with sonography: ballistic trauma.
  Intensive care medicine 2016 Legrand M, Russell R
• Urine sodium concentration to predict fluid responsiveness in oliguric ICU patients: a prospective multicenter observational study.
  Critical care (London, England) 2016 Legrand M, Le Cam B, Perbet S, Roger C, Darmon M, Guerci P, Ferry A, Maurel V, Soussi S, Constantin JM, Gayat E, Lefrant JY, Leone M, support of the AZUREA network
• Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies).
  Annals of intensive care 2016 Ichai C, Vinsonneau C, Souweine B, Armando F, Canet E, Clec'h C, Constantin JM, Darmon M, Duranteau J, Gaillot T, Garnier A, Jacob L, Joannes-Boyau O, Juillard L, Journois D, Lautrette A, Muller L, …
• Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies).
  Anaesthesia, critical care & pain medicine 2016 Ichai C, Vinsonneau C, Souweine B, Armando F, Canet E, Clec'h C, Constantin JM, Darmon M, Duranteau J, Gaillot T, Garnier A, Jacob L, Joannes-Boyau O, Juillard L, Journois D, Lautrette A, Muller L, …
• Heart rate variability and cardiac baroreflex inhibition-derived index predicts pain perception in burn patients.
  Burns : journal of the International Society for Burn Injuries 2016 Papaioannou V, Chouvarda I, Gaertner E, Benyamina M, Ferry A, Maurel V, Soussi S, Blet A, Chaouat M, Plaud B, Mebazaa A, Legrand M, PRONOBURN Group
• Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure.
  Journal of intensive care 2016 Mebazaa A, Laterre PF, Russell JA, Bergmann A, Gattinoni L, Gayat E, Harhay MO, Hartmann O, Hein F, Kjolbye AL, Legrand M, Lewis RJ, Marshall JC, Marx G, Radermacher P, Schroedter M, Scigalla P, …
• Use of Prophylactic Antibiotics in Mechanically Ventilated Patients With Burn Injuries.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2016 Legrand M, Lafaurie M
• Risk of oxalate nephropathy with the use of cyanide antidote hydroxocobalamin in critically ill burn patients.
  Intensive care medicine 2016 Legrand M, Michel T, Daudon M, Benyamina M, Ferry A, Soussi S, Maurel V, Chaussard M, Chaouat M, Mimoun M, Verine J, Mallet V, Mebazaa A, PRONOBURN Study Group
• The new Sfar journals are in place.
  Anaesthesia, critical care & pain medicine 2016 Plaud B, Lefrant JY, Editorial Board, Anaesthesia Critical Care & Pain Medicine
• Intravenous Fluids in AKI: A Mechanistically Guided Approach.
  Seminars in nephrology 2016 Legrand M, Ince C
• Renal replacement therapy in adult and pediatric intensive care : Recommendations by an expert panel from the French Intensive Care Society (SRLF) with the French Society of Anesthesia Intensive Care (SFAR) French Group for Pediatric Intensive Care Emergencies (GFRUP) the French Dialysis Society (SFD).
  Annals of intensive care 2015 Vinsonneau C, Allain-Launay E, Blayau C, Darmon M, Ducheyron D, Gaillot T, Honore PM, Javouhey E, Krummel T, Lahoche A, Letacon S, Legrand M, Monchi M, Ridel C, Robert R, Schortgen F, Souweine B, …
• Cross-talk phenomenon during femoral transpulmonary thermodilution in a critically ill patient.
  Anaesthesia, critical care & pain medicine 2015 Soussi S, Ferry A, Bahaji M, De Tymowski C, Legrand M
• Influence of the central venous site on the transpulmonary thermodilution parameters in critically ill burn patients.
  Burns : journal of the International Society for Burn Injuries 2015 Soussi S, Sisso F, Maurel V, Oueslati H, Legrand M
• Erratum to: Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases.
  Intensive care medicine 2015 Leone M, Bechis C, Baumstarck K, Ouattara A, Collange O, Augustin P, Annane D, Arbelot C, Asehnoune K, Baldési O, Bourcier S, Delapierre L, Demory D, Hengy B, Ichai C, Kipnis E, Brasdefer E, Lasocki S…
• Muscle diffusion of liposomal amphotericin B and posaconazole in critically ill burn patients receiving continuous hemodialysis.
  Intensive care medicine 2015 Ressaire Q, Padoin C, Chaouat M, Maurel V, Alanio A, Ferry A, Soussi S, Benyamina M, Denis B, Mimoun M, Mebazaa A, Legrand M
• Fenoldopam and acute kidney injury.
  JAMA 2015 Legrand M, Darmon M, Joannidis M
• Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases.
  Intensive care medicine 2015 Leone M, Bechis C, Baumstarck K, Ouattara A, Collange O, Augustin P, Annane D, Arbelot C, Asehnoune K, Baldési O, Bourcier S, Delapierre L, Demory D, Hengy B, Ichai C, Kipnis E, Brasdefer E, Lasocki S…
• Comparison between admission natriuretic peptides, NGAL and sST2 testing for the prediction of worsening renal function in patients with acutely decompensated heart failure.
  Clinical chemistry and laboratory medicine 2015 De Berardinis B, Gaggin HK, Magrini L, Belcher A, Zancla B, Femia A, Simon M, Motiwala S, Bhardwaj A, Parry BA, Nagurney JT, Coudriou C, Legrand M, Sadoune M, Di Somma S, Januzzi JL, Global Research …
• Erratum to: Failure of renal biomarkers to predict worsening renal function in high-risk patients presenting with oliguria.
  Intensive care medicine 2015 Legrand M, Jacquemod A, Gayat E, Collet C, Giraudeaux V, Launay JM, Payen D
• Ten tips for managing critically ill burn patients: follow the RASTAFARI!
  Intensive care medicine 2015 Legrand M, Guttormsen AB, Berger MM
• Failure of renal biomarkers to predict worsening renal function in high-risk patients presenting with oliguria.
  Intensive care medicine 2014 Legrand M, Jacquemod A, Gayat E, Collet C, Giraudeaux V, Launay JM, Payen D
• Biomarkers for AKI improve clinical practice: yes.
  Intensive care medicine 2014 Legrand M, Darmon M
• Evidence of uncoupling between renal dysfunction and injury in cardiorenal syndrome: insights from the BIONICS study.
  PloS one 2014 Legrand M, De Berardinis B, Gaggin HK, Magrini L, Belcher A, Zancla B, Femia A, Simon M, Motiwala S, Sambhare R, Di Somma S, Mebazaa A, Vaidya VS, Januzzi JL, Global Research on Acute Conditions Team…
• Reply: To PMID 24667613.
  Shock (Augusta, Ga.) 2014 Legrand M, Payen D, Vallée F, Mateo J
• When cardiac failure, kidney dysfunction, and kidney injury intersect in acute conditions: the case of cardiorenal syndrome.
  Critical care medicine 2014 Legrand M, Mebazaa A, Ronco C, Januzzi JL
• Neutrophil gelatinase-associated lipocalin: ready for routine clinical use? An international perspective.
  Blood purification 2014 Ronco C, Legrand M, Goldstein SL, Hur M, Tran N, Howell EC, Cantaluppi V, Cruz DN, Damman K, Bagshaw SM, Di Somma S, Lewington A
• Influence of arterial dissolved oxygen level on venous oxygen saturation: don't forget the PaO2!
  Shock (Augusta, Ga.) 2014 Legrand M, Vallée F, Mateo J, Payen D
• 'Chronomics' in ICU: circadian aspects of immune response and therapeutic perspectives in the critically ill.
  Intensive care medicine experimental 2014 Papaioannou V, Mebazaa A, Plaud B, Legrand M
• In reply.
  Anesthesiology 2014 Legrand M, Payen D
• Etomidate and general anesthesia: the butterfly effect?
  Anesthesia and analgesia 2013 Legrand M, Plaud B
• Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study.
  Critical care (London, England) 2013 Legrand M, Dupuis C, Simon C, Gayat E, Mateo J, Lukaszewicz AC, Payen D
• Incidence, risk factors and prediction of post-operative acute kidney injury following cardiac surgery for active infective endocarditis: an observational study.
  Critical care (London, England) 2013 Legrand M, Pirracchio R, Rosa A, Petersen ML, Van der Laan M, Fabiani JN, Fernandez-gerlinger MP, Podglajen I, Safran D, Cholley B, Mainardi JL
• Novelties in biomarkers for the management of circulatory failure.
  Current opinion in critical care 2013 Legrand M, Gayat E
• NGAL and AKI: the end of a myth?
  Intensive care medicine 2013 Legrand M, Darmon M, Joannidis M
• Critical research on biomarkers: what's new?
  Intensive care medicine 2013 Legrand M, Januzzi JL, Mebazaa A
• Case scenario: Hemodynamic management of postoperative acute kidney injury.
  Anesthesiology 2013 Legrand M, Payen D
• The elusive task of biomarkers of renal injury.
  Critical care (London, England) 2013 Legrand M, Mari A, Mebazaa A
• Transcranial Doppler monitoring may be misleading in prediction of elevated ICP in brain-injured patients.
  Intensive care medicine 2013 Ahmad M, Legrand M, Lukaszewicz AC, Charlier P, Mateo J, Payen D
• Accuracy of urine NGAL commercial assays in critically ill patients.
  Intensive care medicine 2012 Legrand M, Collet C, Gayat E, Henao J, Giraudeaux V, Mateo J, Launay JM, Payen D
• Management of renal replacement therapy in ICU patients: an international survey.
  Intensive care medicine 2012 Legrand M, Darmon M, Joannidis M, Payen D
• Diagnostic accuracy of insulin-like growth factor binding protein-1 for amniotic fluid embolism*.
  Critical care medicine 2012 Legrand M, Rossignol M, Dreux S, Luton D, Ventré C, Barranger E, Laribi S, Payen D, Muller F
• A multicentre study of acute kidney injury in severe sepsis and septic shock: association with inflammatory phenotype and HLA genotype.
  PloS one 2012 Payen D, Lukaszewicz AC, Legrand M, Gayat E, Faivre V, Megarbane B, Azoulay E, Fieux F, Charron D, Loiseau P, Busson M
• Survival in neutropenic patients with severe sepsis or septic shock.
  Critical care medicine 2012 Legrand M, Max A, Peigne V, Mariotte E, Canet E, Debrumetz A, Lemiale V, Seguin A, Darmon M, Schlemmer B, Azoulay E
• Can we identify prerenal physiology and does it matter?
  Contributions to nephrology 2011 Payen D, Legrand M
• Effects of sepiapterin infusion on renal oxygenation and early acute renal injury after suprarenal aortic clamping in rats.
  Journal of cardiovascular pharmacology 2011 Legrand M, Kandil A, Payen D, Ince C
• The use of dabigatran in elderly patients.
  Archives of internal medicine 2011 Legrand M, Mateo J, Aribaud A, Ginisty S, Eftekhari P, Huy PT, Drouet L, Payen D
• Microvascular and interstitial oxygen tension in the renal cortex and medulla studied in a 4-h rat model of LPS-induced endotoxemia.
  Shock (Augusta, Ga.) 2011 Dyson A, Bezemer R, Legrand M, Balestra G, Singer M, Ince C
• The role of renal hypoperfusion in development of renal microcirculatory dysfunction in endotoxemic rats.
  Intensive care medicine 2011 Legrand M, Bezemer R, Kandil A, Demirci C, Payen D, Ince C
• The strategy of antibiotic use in critically ill neutropenic patients.
  Annals of intensive care 2011 Legrand M, Max A, Schlemmer B, Azoulay E, Gachot B
• Arterial catheter-related bloodstream infections: results of an 8-year survey in a surgical intensive care unit.
  Critical care medicine 2011 Pirracchio R, Legrand M, Rigon MR, Mateo J, Lukaszewicz AC, Mebazaa A, Raskine L, Le Pors MJ, Payen D
• Understanding urine output in critically ill patients.
  Annals of intensive care 2011 Legrand M, Payen D
• Evaluation of multi-exponential curve fitting analysis of oxygen-quenched phosphorescence decay traces for recovering microvascular oxygen tension histograms.
  Medical & biological engineering & computing 2010 Bezemer R, Faber DJ, Almac E, Kalkman J, Legrand M, Heger M, Ince C
• Real-time assessment of renal cortical microvascular perfusion heterogeneities using near-infrared laser speckle imaging.
  Optics express 2010 Bezemer R, Legrand M, Klijn E, Heger M, Post IC, van Gulik TM, Payen D, Ince C
• Intensity of continuous renal-replacement therapy.
  The New England journal of medicine 2010 Legrand M, Payen D
• Echocardiography in hemodynamic monitoring.
  Chest 2010 Chimot L, Legrand M, Canet E, Lemiale V, Azoulay E
• The response of the host microcirculation to bacterial sepsis: does the pathogen matter?
  Journal of molecular medicine (Berlin, Germany) 2010 Legrand M, Klijn E, Payen D, Ince C
• Fluid resuscitation does not improve renal oxygenation during hemorrhagic shock in rats.
  Anesthesiology 2010 Legrand M, Mik EG, Balestra GM, Lutter R, Pirracchio R, Payen D, Ince C
• The role of the microcirculation in acute kidney injury.
  Current opinion in critical care 2009 Le Dorze M, Legrand M, Payen D, Ince C
• Microcirculation and mitochondria in sepsis: getting out of breath.
  Current opinion in anaesthesiology 2009 Balestra GM, Legrand M, Ince C
• L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats.
  American journal of physiology. Renal physiology 2009 Legrand M, Almac E, Mik EG, Johannes T, Kandil A, Bezemer R, Payen D, Ince C
• Paediatric intracranial empyema: differences according to age.
  European journal of pediatrics 2009 Legrand M, Roujeau T, Meyer P, Carli P, Orliaguet G, Blanot S
• Renal hypoxia and dysoxia after reperfusion of the ischemic kidney.
  Molecular medicine (Cambridge, Mass.) 2008 Legrand M, Mik EG, Johannes T, Payen D, Ince C
• Pleural drain malposition.
  Intensive care medicine 2006 Legrand M, Lecuyer L, Van De Louw A, Thierry S
• Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron.
  Anesthesiology 2005 Charbit B, Albaladejo P, Funck-Brentano C, Legrand M, Samain E, Marty J