Matthias Wabl, PhD
Professor Emeritus
Microbiology and Immunology
School of Medicine

Websites

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• Profile at immunology.ucsf.edu (immunology.ucsf.edu)

Grants and Projects

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• Peptides presented by DNA-specific B lymphocytes in lupus, NIH, 2014-2016
• The role of Apobec3 enzymes in regulation of marginal zone B cells, NIH, 2013-2016
• Gene Targeted Mice with a Simplified Immune System, NIH, 1997-2016
• Tumor Suppressors in Lymphocytes, NIH, 2006-2009
• Genetic Variation in B-Lymphocyte Ontogeny, NIH, 1987-2007
• Genetic Variation in B Lymphocyte Ontogeny, NIH, 1987-2001
• Gene Targeted Mice with a Simplified Immune System, NIH, 1997-1998
• Immunoglobulin Gene Targeting into the Mouse Germ Line, NIH, 1990-1993

Publications (113)

Top publication keywords:
Cytidine DeaminaseImmunoglobulin Class SwitchingImmunoglobulin mu-ChainsMice, Inbred NZBMutagenesis, InsertionalRetroelementsLeukemia Virus, MurineB-Lymphocyte SubsetsVirus IntegrationGenes, ImmunoglobulinB-LymphocytesRetroviridaeSomatic Hypermutation, ImmunoglobulinImmunoglobulin Heavy ChainsImmunoglobulin Variable Region

• Infectivity and insertional mutagenesis of endogenous retrovirus in autoimmune NZB and B/W mice.
  The Journal of general virology 2015 Beck-Engeser GB, Ahrends T, Knittel G, Wabl R, Metzner M, Eilat D, Wabl M
• APOBEC3 enzymes restrict marginal zone B cells.
  European journal of immunology 2015 Beck-Engeser GB, Winkelmann R, Wheeler ML, Shansab M, Yu P, Wünsche S, Walchhütter A, Metzner M, Vettermann C, Eilat D, DeFranco A, Jäck HM, Wabl M
• Insertional hypermutation in mineral oil-induced plasmacytomas.
  European journal of immunology 2014 Knittel G, Metzner M, Beck-Engeser G, Kan A, Ahrends T, Eilat D, Huppi K, Wabl M
• Novel principles of gamma-retroviral insertional transcription activation in murine leukemia virus-induced end-stage tumors.
  Retrovirology 2014 Sokol M, Wabl M, Ruiz IR, Pedersen FS
• Gene expression profiling of murine T-cell lymphoblastic lymphoma identifies deregulation of S-phase initiating genes.
  Leukemia research 2013 Dabrowska MJ, Ejegod D, Lassen LB, Johnsen HE, Wabl M, Pedersen FS, Dybkær K

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• Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.
  Science signaling 2013 Hartzell C, Ksionda O, Lemmens E, Coakley K, Yang M, Dail M, Harvey RC, Govern C, Bakker J, Lenstra TL, Ammon K, Boeter A, Winter SS, Loh M, Shannon K, Chakraborty AK, Wabl M, Roose JP
• LINE-1 retroelements complexed and inhibited by activation induced cytidine deaminase.
  PloS one 2012 Metzner M, Jäck HM, Wabl M
• B cell tolerance and positive selection in lupus.
  Journal of immunology (Baltimore, Md. : 1950) 2012 Eilat D, Wabl M
• Psoriasis patients are enriched for genetic variants that protect against HIV-1 disease.
  PLoS genetics 2012 Chen H, Hayashi G, Lai OY, Dilthey A, Kuebler PJ, Wong TV, Martin MP, Fernandez Vina MA, McVean G, Wabl M, Leslie KS, Maurer T, Martin JN, Deeks SG, Carrington M, Bowcock AM, Nixon DF, Liao W
• Sequential class switching is required for the generation of high affinity IgE antibodies.
  The Journal of experimental medicine 2012 Xiong H, Dolpady J, Wabl M, Curotto de Lafaille MA, Lafaille JJ
• CD22 serves as a receptor for soluble IgM.
  European journal of immunology 2011 Adachi T, Harumiya S, Takematsu H, Kozutsumi Y, Wabl M, Fujimoto M, Tedder TF
• An autoimmune disease prevented by anti-retroviral drugs.
  Retrovirology 2011 Beck-Engeser GB, Eilat D, Wabl M
• Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Lutz J, Heideman MR, Roth E, van den Berk P, Müller W, Raman C, Wabl M, Jacobs H, Jäck HM
• Overbuilding: overhead revisions.
  Science (New York, N.Y.) 2010 Wabl M
• A retroviral mutagenesis screen identifies Cd74 as a common insertion site in murine B-lymphomas and reveals the existence of a novel IFNgamma-inducible Cd74 isoform.
  Molecular cancer 2010 Pyrz M, Wang B, Wabl M, Pedersen FS
• Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer.
  BMC cancer 2010 Lum AM, Wang BB, Beck-Engeser GB, Li L, Channa N, Wabl M
• Two forms of activation-induced cytidine deaminase differing in their ability to bind agarose.
  PloS one 2010 Metzner M, Schuh W, Roth E, Jäck HM, Wabl M
• Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Beck-Engeser GB, Eilat D, Harrer T, Jäck HM, Wabl M
• Activation of alternative Jdp2 promoters and functional protein isoforms in T-cell lymphomas by retroviral insertion mutagenesis.
  Nucleic acids research 2009 Rasmussen MH, Wang B, Wabl M, Nielsen AL, Pedersen FS
• Loss of MicroRNA targets in the 3' untranslated region as a mechanism of retroviral insertional activation of growth factor independence 1.
  Journal of virology 2009 Dabrowska MJ, Dybkaer K, Johnsen HE, Wang B, Wabl M, Pedersen FS
• Activation of the brain-specific neurogranin gene in murine T-cell lymphomas by proviral insertional mutagenesis.
  Gene 2009 Nielsen AA, Kjartansdóttir KR, Rasmussen MH, Sørensen AB, Wang B, Wabl M, Pedersen FS
• Identification of novel Bach2 transcripts and protein isoforms through tagging analysis of retroviral integrations in B-cell lymphomas.
  BMC molecular biology 2009 Liu J, Sørensen AB, Wang B, Wabl M, Nielsen AL, Pedersen FS
• Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Liao JJ, Huang MC, Fast K, Gundling K, Yadav M, Van Brocklyn JR, Wabl MR, Goetzl EJ
• Expression of Aire and the early wave of apoptosis in spermatogenesis.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Schaller CE, Wang CL, Beck-Engeser G, Goss L, Scott HS, Anderson MS, Wabl M
• Pvt1-encoded microRNAs in oncogenesis.
  Retrovirology 2008 Beck-Engeser GB, Lum AM, Huppi K, Caplen NJ, Wang BB, Wabl M
• Differentiation and Ig-allele switch in cell line WEHI-231.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Spillmann FJ, Beck-Engeser G, Wabl M
• Ig heavy chain promotes mature B cell survival in the absence of light chain.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Geraldes P, Rebrovich M, Herrmann K, Wong J, Jäck HM, Wabl M, Cascalho M
• Impairment of alternative splice sites defining a novel gammaretroviral exon within gag modifies the oncogenic properties of Akv murine leukemia virus.
  Retrovirology 2007 Sørensen AB, Lund AH, Kunder S, Quintanilla-Martinez L, Schmidt J, Wang B, Wabl M, Pedersen FS
• Retroviral activation of the mir-106a microRNA cistron in T lymphoma.
  Retrovirology 2007 Lum AM, Wang BB, Li L, Channa N, Bartha G, Wabl M
• Activation of an oncogenic microRNA cistron by provirus integration.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Wang CL, Wang BB, Bartha G, Li L, Channa N, Klinger M, Killeen N, Wabl M
• Slow, stochastic transgene repression with properties of a timer.
  Genome biology 2006 Wang CL, Yang DC, Wabl M
• A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus.
  Blood 2005 Glud SZ, Sørensen AB, Andrulis M, Wang B, Kondo E, Jessen R, Krenacs L, Stelkovics E, Wabl M, Serfling E, Palmetshofer A, Pedersen FS
• Somatic hypermutation and mismatch repair in non-B cells.
  European journal of immunology 2005 Klasen M, Spillmann FJ, Marra G, Cejka P, Wabl M
• Hypermutation rate normalized by chronological time.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Wang CL, Wabl M
• Retroviral vectors to monitor somatic hypermutation.
  Journal of immunological methods 2005 Klasen M, Spillmann FJ, Lorens JB, Wabl M
• Mutational activity in cell line WEHI-231.
  Immunogenetics 2004 Wang CL, Wabl M
• Autoreactivity and allelic inclusion in a B cell nuclear transfer mouse.
  Nature immunology 2004 Gerdes T, Wabl M
• Directed molecular evolution by somatic hypermutation.
  Protein engineering, design & selection : PEDS 2004 Wang CL, Yang DC, Wabl M
• Precise dosage of an endogenous mutagen in the immune system.
  Cell cycle (Georgetown, Tex.) 2004 Wang CL, Wabl M
• Endogenous expression of activation-induced cytidine deaminase in cell line WEHI-231.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Spillmann FJ, Wabl M
• DNA acrobats of the Ig class switch.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Wang CL, Wabl M
• Genome-wide somatic hypermutation.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Wang CL, Harper RA, Wabl M
• A murine leukemia virus with Cre-LoxP excisible coding sequences allowing superinfection, transgene delivery, and generation of host genomic deletions.
  Retrovirology 2004 Wang CL, Hodgson JG, Malek T, Pedersen FS, Wabl M
• Silent point mutation in DsRed resulting in enhanced relative fluorescence intensity.
  BioTechniques 2004 Klasen M, Wabl M
• DNA-PKcs function regulated specifically by protein phosphatase 5.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Wechsler T, Chen BP, Harper R, Morotomi-Yano K, Huang BC, Meek K, Cleaver JE, Chen DJ, Wabl M
• Inhibitory coreceptors activated by antigens but not by anti-Ig heavy chain antibodies install requirement of costimulation through CD40 for survival and proliferation of B cells.
  Journal of immunology (Baltimore, Md. : 1950) 2003 Hokazono Y, Adachi T, Wabl M, Tada N, Amagasa T, Tsubata T
• The possibility of B-cell-dependent T-cell development.
  Scandinavian journal of immunology 2003 Keshavarzi S, Rietz C, Simões S, Shih S, Platt JL, Wong J, Wabl M, Cascalho M
• Contribution of light chain rearrangement in peripheral B cells to the generation of high-affinity antibodies.
  European journal of immunology 2002 Magari M, Sawatari T, Kawano Y, Cascalho M, Wabl M, Kanayama N, Hikida M, Ohmori H
• SWAP-70-deficient mast cells are impaired in development and IgE-mediated degranulation.
  European journal of immunology 2002 Gross B, Borggrefe T, Wabl M, Sivalenka RR, Bennett M, Rossi AB, Jessberger R
• VH gene replacement in thymocytes.
  Journal of immunology (Baltimore, Md. : 1950) 2001 Golub R, Martin D, Bertrand FE, Cascalho M, Wabl M, Wu GE
• B cell immunopoiesis: visualizing the impact of CD40 engagement on the course of T cell-independent immune responses in an Ig transgenic system.
  European journal of immunology 2000 Erickson LD, Vogel LA, Cascalho M, Wong J, Wabl M, Durell BG, Noelle RJ
• Specific antibody production by V(H)-gene replacement.
  European journal of immunology 2000 Madan MK, Golub R, Wabl M, Wu GE
• Association of SWAP-70 with the B cell antigen receptor complex.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Masat L, Caldwell J, Armstrong R, Khoshnevisan H, Jessberger R, Herndier B, Wabl M, Ferrick D
• Germinal centers without T cells.
  The Journal of experimental medicine 2000 de Vinuesa CG, Cook MC, Ball J, Drew M, Sunners Y, Cascalho M, Wabl M, Klaus GG, MacLennan IC
• A B220(-), CD19(-) population of B cells in the peripheral blood of quasimonoclonal mice.
  International immunology 2000 Cascalho M, Wong J, Brown J, Jäck HM, Steinberg C, Wabl M
• Mapping of the SWAP70 gene to mouse chromosome 7 and human chromosome 11p15.
  Immunogenetics 2000 Masat L, Liddell RA, Mock BA, Kuo WL, Jessberger R, Wabl M, Morse HC
• Dendritic cells associated with plasmablast survival.
  European journal of immunology 1999 García De Vinuesa C, Gulbranson-Judge A, Khan M, O'Leary P, Cascalho M, Wabl M, Klaus GG, Owen MJ, MacLennan IC
• Secondary rearrangements and hypermutation generate sufficient B cell diversity to mount protective antiviral immunoglobulin responses.
  The Journal of experimental medicine 1999 López-Macías C, Kalinke U, Cascalho M, Wabl M, Hengartner H, Zinkernagel RM, Lamarre A
• Cellular, intracellular, and developmental expression patterns of murine SWAP-70.
  European journal of immunology 1999 Borggrefe T, Masat L, Wabl M, Riwar B, Cattoretti G, Jessberger R
• Hypermutation in antibody affinity maturation.
  Current opinion in immunology 1999 Wabl M, Cascalho M, Steinberg C
• A mouse with a monoclonal primary immunoglobulin repertoire not further diversified by V-gene replacement.
  Developmental immunology 1999 Cascalho M, Martin DA, Wong J, Lam Q, Wabl M, Wu GE
• A B-cell-specific DNA recombination complex.
  The Journal of biological chemistry 1998 Borggrefe T, Wabl M, Akhmedov AT, Jessberger R
• The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Bachl J, Olsson C, Chitkara N, Wabl M
• Mismatch repair co-opted by hypermutation.
  Science (New York, N.Y.) 1998 Cascalho M, Wong J, Steinberg C, Wabl M
• VH gene replacement in hyperselected B cells of the quasimonoclonal mouse.
  Journal of immunology (Baltimore, Md. : 1950) 1997 Cascalho M, Wong J, Wabl M
• Critical test of hot spot motifs for immunoglobulin hypermutation.
  European journal of immunology 1997 Bachl J, Steinberg C, Wabl M
• Inducible expression of the beta 1 subunit of the sodium pump.
  Biological chemistry 1997 Masat L, Wabl M
• A protein binding specifically to the IgG2b switch region.
  Developmental immunology 1997 Völk H, Wabl M
• Loss of the beta 1 subunit of the sodium pump during lymphocyte differentiation.
  European journal of immunology 1996 Masat L, Cascalho M, Wabl M
• A quasi-monoclonal mouse.
  Science (New York, N.Y.) 1996 Cascalho M, Ma A, Lee S, Masat L, Wabl M
• Translatable immunoglobulin germ-line transcript.
  European journal of immunology 1996 Bachl J, Turck CW, Wabl M
• Affinity maturation and class switching.
  Current opinion in immunology 1996 Wabl M, Steinberg C
• An immunoglobulin mutator that targets G.C base pairs.
  Proceedings of the National Academy of Sciences of the United States of America 1996 Bachl J, Wabl M
• Biochemical studies of class switch recombination.
  Current topics in microbiology and immunology 1996 Jessberger R, Wabl M, Borggrefe T
• Enhancers of hypermutation.
  Immunogenetics 1996 Bachl J, Wabl M
• Somatic hypermutability.
  Current topics in microbiology and immunology 1996 Wabl M, Steinberg C
• A video technique for the quantification of DNA in gels stained with ethidium bromide.
  Analytical biochemistry 1995 Harriman WD, Wabl M
• A rapid assay for detecting cellular TdT enzymatic activity.
  Journal of immunological methods 1995 Harriman W, Fischer ER, Wabl M
• Immunoglobulin variable gene segment VH81X of the mouse is embedded in L1 transposon sequences.
  Immunogenetics 1995 Bachl J, Defranoux N, Wabl M
• Large cytoplasmic inclusion body kappa-chain has unusual intrachain disulfide bonding.
  Journal of immunology (Baltimore, Md. : 1950) 1993 Jäck HM, Sloan B, Grisham G, Reason D, Wabl M
• Immunoglobulin class switch recombination.
  Annual review of immunology 1993 Harriman W, Völk H, Defranoux N, Wabl M
• A different sort of Mott cell.
  Proceedings of the National Academy of Sciences of the United States of America 1992 Jäck HM, Beck-Engeser G, Sloan B, Wong ML, Wabl M
• Allelic exclusion model questioned.
  Nature 1992 Wabl M, Steinberg C
• Tumorigenesis mediated by an antigen receptor.
  Proceedings of the National Academy of Sciences of the United States of America 1992 Jäck HM, Beck-Engeser G, Lee G, Wofsy D, Wabl M
• The murine IgG1/IgE class switch program.
  European journal of immunology 1992 Siebenkotten G, Esser C, Wabl M, Radbruch A
• HeLa-LAV, an epithelial cell line stably infected with HIV-1.
  Journal of virological methods 1991 Berg J, Doe B, Steimer KS, Wabl M
• Bispecific antibodies that mediate killing of cells infected with human immunodeficiency virus of any strain.
  Proceedings of the National Academy of Sciences of the United States of America 1991 Berg J, Lötscher E, Steimer KS, Capon DJ, Baenziger J, Jäck HM, Wabl M
• Beswitched. The looping out model for immunoglobulin class switching.
  The New biologist 1990 von Schwedler U, Jäck HM, Wabl M
• Circular DNA is a product of the immunoglobulin class switch rearrangement.
  Nature 1990 von Schwedler U, Jäck HM, Wabl M
• Immunoglobulin lambda gene rearrangement can precede kappa gene rearrangement.
  Developmental immunology 1990 Berg J, McDowell M, Jäck HM, Wabl M
• Translation affects immunoglobulin mRNA stability.
  European journal of immunology 1989 Jäck HM, Berg J, Wabl M
• Scope of action of the immunoglobulin mutator system.
  Genome 1989 Wabl MR, Jäck HM, von Borstel RC, Steinberg CM
• Immunoglobulin mRNA stability varies during B lymphocyte differentiation.
  The EMBO journal 1988 Jäck HM, Wabl M
• Looping out and deletion mechanism for the immunoglobulin heavy-chain class switch.
  Proceedings of the National Academy of Sciences of the United States of America 1988 Jäck HM, McDowell M, Steinberg CM, Wabl M
• High rates of deletions in the constant region segment of the immunoglobulin mu gene.
  Proceedings of the National Academy of Sciences of the United States of America 1987 Jäck HM, Wabl M
• Measurements of mutation rates in B lymphocytes.
  Immunological reviews 1987 Wabl M, Jäck HM, Meyer J, Beck-Engeser G, von Borstel RC, Steinberg CM
• Allelic inclusion in a pre-B-cell line that generates immunoglobulin heavy chain genes in vitro.
  Proceedings of the National Academy of Sciences of the United States of America 1987 Beck-Engeser G, Jäck HM, Wabl M
• Possible target of Abelson virus phosphokinase in cell transformation.
  Experientia 1986 Pantelias G, Jäck HM, Wabl M
• High rate of somatic point mutation in vitro in and near the variable-region segment of an immunoglobulin heavy chain gene.
  Proceedings of the National Academy of Sciences of the United States of America 1986 Meyer J, Jäck HM, Ellis N, Wabl M
• V lambda 2 rearranges with all functional J lambda segments in the mouse.
  European journal of immunology 1985 Weiss S, Meyer J, Wabl MR
• Critical test of a sister chromatid exchange model for the immunoglobulin heavy-chain class switch.
  Nature 1985 Wabl M, Meyer J, Beck-Engeser G, Tenkhoff M, Burrows PD
• Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.
  Proceedings of the National Academy of Sciences of the United States of America 1985 Wabl M, Burrows PD, von Gabain A, Steinberg C
• Immunoglobulin heavy chain toxicity in plasma cells is neutralized by fusion to pre-B cells.
  Proceedings of the National Academy of Sciences of the United States of America 1984 Haas IG, Wabl MR
• A Mott cell hybridoma.
  European journal of immunology 1984 Weiss S, Burrows PD, Meyer J, Wabl MR
• Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cis.
  Proceedings of the National Academy of Sciences of the United States of America 1984 Wabl MR, Burrows PD
• Allelic inclusion in the pre-B-cell line 18-81.
  Proceedings of the National Academy of Sciences of the United States of America 1984 Wabl MR, Beck-Engeser GB, Burrows PD
• Immunoglobulin heavy chain binding protein.
  Nature 1983 Haas IG, Wabl M
• Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement.
  Nature 1983 Burrows PD, Beck-Engeser GB, Wabl MR
• A theory of allelic and isotypic exclusion for immunoglobulin genes.
  Proceedings of the National Academy of Sciences of the United States of America 1982 Wabl M, Steinberg C
• Allelic exclusion of immunoglobulin expression is not caused by somatic segregation.
  Proceedings of the National Academy of Sciences of the United States of America 1982 Wabl MR, Tenkhoff M
• Thirteen hybridomas secreting hapten-specific immunoglobulin E from mice with Iga or Igb heavy chain haplotype.
  European journal of immunology 1981 Rudolph AK, Burrows PD, Wabl MR
• Expression of mu and gamma immunoglobulin heavy chains in different cells of a cloned mouse lymphoid line.
  Proceedings of the National Academy of Sciences of the United States of America 1981 Burrows PD, Beck GB, Wabl MR
• Simultaneous expression of mouse immunoglobulins M and D is determined by the same homolog of chromosome 12.
  Proceedings of the National Academy of Sciences of the United States of America 1980 Wabl MR, Johnson JP, Haas IG, Tenkhoff M, Meo T, Inan R