Matthias Behrends, MD
Professor
Anesthesia
School of Medicine

In his research, he focuses on clinical trials on how to improve pain after surgery. He also investigates the effects of pain and pain medication on pupil movements using infrared pupillometry.

Behrends earned his medical degree from the University of Göttingen. He trained in anesthesiology at the University of Duisburg-Essen. He also spent three years as a postdoctoral scholar in the pathophysiology department at the University of Duisburg-Essen, investigating myocardial hibernation and ischemic preconditioning.

• Optimizing Uptake of Multimodal Pain Management After Surgery Using the Electronic Health Record.
  JAMA surgery 2023 Bongiovanni T, Lancaster E, Behrends M, Zhang L, Wick E, Auerbach A, Pletcher MJ
• A behavioral intervention to promote use of multimodal pain medication for hospitalized patients: A randomized controlled trial.
  Journal of hospital medicine 2023 Bongiovanni T, Pletcher MJ, Lau C, Robinson A, Lancaster E, Zhang L, Behrends M, Wick E, Auerbach A
• Consensus guidelines for the perioperative management of patients undergoing endoscopic retrograde cholangiopancreatography.
  British journal of anaesthesia 2023 Azimaraghi O, Bilal M, Amornyotin S, Arain M, Behrends M, Berzin TM, Buxbaum JL, Choice C, Fassbender P, Sawhney MS, Sundar E, Wongtangman K, Leslie K, Eikermann M
• Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial.
  BMJ open 2022 Buren MA, Theologis A, Zuraek A, Behrends M, Clark AJ, Leung JM
• Neuraxial and general anesthesia for outpatient total joint arthroplasty result in similarly low rates of major perioperative complications: a multicentered cohort study.
  Regional anesthesia and pain medicine 2022 Yap E, Wei J, Webb C, Ng K, Behrends M
• Extraplexus versus intraplexus ultrasound-guided interscalene brachial plexus block for ambulatory arthroscopic shoulder surgery: A randomized controlled trial.
  PloS one 2021 Harbell MW, Kolodzie K, Behrends M, Ma CB, Kinjo S, Yap E, Braehler MR, Aleshi P
• Editorial Commentary: Neuraxial Anesthesia Improves Pain After Hip Arthroscopy but Risks Ambulatory Discharge Delay.
  Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2021 Yap EN, Behrends M
• Perioperative outcomes for patients on chronic buprenorphine undergoing spine surgery: A case series.
  Journal of opioid management 2021 Sharp AL, Gilbert S, Perez DN, Kolodzie K, Behrends M
• Comparison of programmed intermittent epidural bolus and continuous epidural infusion for post-operative analgesia after major abdominal surgery: A randomized controlled trial.
  Journal of clinical anesthesia 2020 Su PP, Peniche A, Clelland E, Ladd M, Delgado A, Chen LL, Siegmueller C, Latronica M, Naidu R, Aleshi P, Behrends M
• International multicentre review of perioperative management and outcome for catecholamine-producing tumours.
  The British journal of surgery 2020 Groeben H, Walz MK, Nottebaum BJ, Alesina PF, Greenwald A, Schumann R, Hollmann MW, Schwarte L, Behrends M, Rössel T, Groeben C, Schäfer M, Lowery A, Hirata N, Yamakage M, Miller JA, Cherry TJ, Nelson…
• Acute Pain in Older Adults: Recommendations for Assessment and Treatment.
  Anesthesiology clinics 2019 Rajan J, Behrends M
• Preoperative Fascia Iliaca Block Does Not Improve Analgesia after Arthroscopic Hip Surgery, but Causes Quadriceps Muscles Weakness: A Randomized, Double-blind Trial.
  Anesthesiology 2018 Behrends M, Yap EN, Zhang AL, Kolodzie K, Kinjo S, Harbell MW, Aleshi P
• Suppression of pupillary unrest by general anesthesia and propofol sedation.
  Journal of clinical monitoring and computing 2018 Behrends M, Larson MD, Neice AE, Bokoch MP
• In Response.
  Anesthesia and analgesia 2017 Neice AE, Larson MD, Behrends M, Bokoch MP
• Prediction of Opioid Analgesic Efficacy by Measurement of Pupillary Unrest.
  Anesthesia and analgesia 2017 Neice AE, Behrends M, Bokoch MP, Seligman KM, Conrad NM, Larson MD
• Combined preoperative femoral and sciatic nerve blockade improves analgesia after anterior cruciate ligament reconstruction: a randomized controlled clinical trial.
  Journal of clinical anesthesia 2016 Harbell MW, Cohen JM, Kolodzie K, Behrends M, Braehler MR, Kinjo S, Feeley BT, Aleshi P
• Portable infrared pupillometry: a review.
  Anesthesia and analgesia 2015 Larson MD, Behrends M
• Blood Transfusion and Postoperative Delirium.
  Current Anesthesiology Reports 2015 Elizabeth L. Whitlock, Matthias Behrends
• Fentanyl, an agonist at the mu opioid receptor, depresses pupillary unrest.
  Autonomic neuroscience : basic & clinical 2015 Bokoch MP, Behrends M, Neice A, Larson MD
• Association between intraoperative blood transfusions and early postoperative delirium in older adults.
  Journal of the American Geriatrics Society 2013 Behrends M, DePalma G, Sands L, Leung J
• Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: a case series.
  Resuscitation 2012 Behrends M, Niemann CU, Larson MD
• Induction of intestinal ischemia reperfusion injury by portal vein outflow occlusion in rats.
  Journal of gastroenterology 2010 Vincenti M, Behrends M, Dang K, Park YH, Hirose R, Blasi-Ibanez A, Liu T, Serkova NJ, Niemann CU
• Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokines.
  The Journal of surgical research 2010 Niemann CU, Xu F, Choi S, Behrends M, Park Y, Hirose R, Maher JJ
• Acute hyperglycemia worsens hepatic ischemia/reperfusion injury in rats.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2009 Behrends M, Martinez-Palli G, Niemann CU, Cohen S, Ramachandran R, Hirose R
• Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats.
  Anesthesiology 2008 Hirose R, Xu F, Dang K, Liu T, Behrends M, Brakeman PR, Wiener-Kronish J, Niemann CU
• Increased severity of renal ischemia-reperfusion injury with venous clamping compared to arterial clamping in a rat model.
  Surgery 2007 Park Y, Hirose R, Dang K, Xu F, Behrends M, Tan V, Roberts JP, Niemann CU
• Myocardial stunning following no flow ischaemia is diminished by levosimendan or cariporide, without benefits of combined administration.
  Resuscitation 2007 Brendt P, Behrends M, Peters J
• Remote renal injury following partial hepatic ischemia/reperfusion injury in rats.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2007 Behrends M, Hirose R, Park YH, Tan V, Dang K, Xu F, Park SH, Niemann CU
• Central venous pressure monitoring during living right donor hepatectomy.
  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2007 Niemann CU, Feiner J, Behrends M, Eilers H, Ascher NL, Roberts JP
• Ischemia-reperfusion injury is more severe in older versus young rat livers.
  The Journal of surgical research 2006 Park Y, Hirose R, Coatney JL, Ferrell L, Behrends M, Roberts JP, Serkova NJ, Niemann CU
• Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in rats.
  Liver international : official journal of the International Association for the Study of the Liver 2006 Behrends M, Hirose R, Serkova NJ, Coatney JL, Bedolli M, Yardi J, Park YH, Niemann CU
• Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion.
  Surgery 2006 Niemann CU, Choi S, Behrends M, Hirose R, Noh J, Coatney JL, Roberts JP, Serkova NJ, Maher JJ
• Recombinant factor VIIa reduces transfusion requirements in liver transplant patients with high MELD scores.
  Transfusion medicine (Oxford, England) 2006 Niemann CU, Behrends M, Quan D, Eilers H, Gropper MA, Roberts JP, Hirose R
• Glutamine does not protect against hepatic warm ischemia/reperfusion injury in rats.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2006 Noh J, Behrends M, Choi S, Bedolli MA, Yardi J, Hirose R, Niemann CU
• Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat livers.
  Anesthesia and analgesia 2005 Niemann CU, Hirose R, Liu T, Behrends M, Brown JL, Kominsky DF, Roberts JP, Serkova N
• Acute lung injury after peppermint oil injection.
  Anesthesia and analgesia 2005 Behrends M, Beiderlinden M, Peters J
• Glutamine does not ameliorate hepatic ischemia/reperfusion injury in rats.
  Journal of Gastrointestinal Surgery 2005 Matthias Behrends, Joonhwa Noh, Soojinna Choi, Ryutaro Hirose, Melanie Bedoli, John P. Roberts, Claus U. Niemann
• Normothermia during partial hepatic ischemia increases hepatic injury.
  Journal of Gastrointestinal Surgery 2005 Matthias Behrends, Ryutaro Hirose, Soojinna Choi, Claus U. Niemann
• Combination of sildenafil and bosentan for nitric oxide withdrawal.
  European journal of anaesthesiology 2005 Behrends M, Beiderlinden M, Peters J
• The calcium sensitizer levosimendan attenuates endotoxin-evoked myocardial dysfunction in isolated guinea pig hearts.
  Intensive care medicine 2003 Behrends M, Peters J
• Signal transduction of ischemic preconditioning.
  Cardiovascular research 2001 Schulz R, Cohen MV, Behrends M, Downey JM, Heusch G
• In vitro validation of a metabolic monitor for gas exchange measurements in ventilated neonates.
  Intensive care medicine 2001 Behrends M, Kernbach M, Bräuer A, Braun U, Peters J, Weyland W
• Minimal protection of the liver by ischemic preconditioning in pigs.
  American journal of physiology. Heart and circulatory physiology 2001 Schulz R, Walz MK, Behrends M, Neumann T, Gerken G, Heusch G
• Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation.
  American journal of physiology. Heart and circulatory physiology 2000 Dörge H, Neumann T, Behrends M, Skyschally A, Schulz R, Kasper C, Erbel R, Heusch G
• No protection of the porcine kidney by ischaemic preconditioning.
  Experimental physiology 2000 Behrends M, Walz MK, Kribben A, Neumann T, Helmchen U, Philipp T, Schulz R, Heusch G
• Enhanced reduction of myocardial infarct size by combined ACE inhibition and AT(1)-receptor antagonism.
  British journal of pharmacology 2000 Weidenbach R, Schulz R, Gres P, Behrends M, Post H, Heusch G
• Inconsistent relation of MAPK activation to infarct size reduction by ischemic preconditioning in pigs.
  American journal of physiology. Heart and circulatory physiology 2000 Behrends M, Schulz R, Post H, Alexandrov A, Belosjorow S, Michel MC, Heusch G
• Intraperitoneal and retroperitoneal carbon dioxide insufflation evoke different effects on caval vein pressure gradients in humans: evidence for the starling resistor concept of abdominal venous return.
  Anesthesiology 2000 Giebler RM, Behrends M, Steffens T, Walz MK, Peitgen K, Peters J
• No involvement of endogenous nitric oxide in classical ischemic preconditioning in swine.
  Journal of molecular and cellular cardiology 2000 Post H, Schulz R, Behrends M, Gres P, Umschlag C, Heusch G
• Attenuation of myocardial stunning by the AT1 receptor antagonist candesartan.
  Basic research in cardiology 1999 Dörge H, Behrends M, Schulz R, Jalowy A, Heusch G
• Effects of verapamil and mibefradil on regional blood flow and function in normal and ischemic myocardium.
  Cardiovascular drugs and therapy 1999 Behrends M, Schulz R, Heusch G
• Infarct size reduction by AT1-receptor blockade through a signal cascade of AT2-receptor activation, bradykinin and prostaglandins in pigs.
  Journal of the American College of Cardiology 1998 Jalowy A, Schulz R, Dörge H, Behrends M, Heusch G
• Caval pressure gradients are induced with intraperitoneal but not with retroperitoneal CO2 insufflation during laparoscopic or retroperitoneoscopic surgical procedures in humans.
  Anesthesiology 1998 R. Giebler, M. Behrends, M. Walz, K. Peitgen, J. Peters