Matthew Zapala, MD, PhD
ASSOCIATE PHYSICIAN DIPLOMATE
Radiology
School of Medicine

In 2010, he completed his one-year internship from Scripps Mercy Hospital in San Diego, California. From 2010-2014, Dr. Zapala finished his four-year Diagnostic Radiology residency from the University of California, San Diego, followed by a pediatric radiology fellowship from Boston Children’s Hospital/Harvard Medical School in 2015.

Dr. Zapala is a member of the Radiologic Society of North America, American Roentgen Ray Society and the Society of Pediatric Radiology.

Specialty: Pediatric Radiology

Expertise: Pediatric imaging

Professional Interests: Pediatric radiology, genomics, radiogenomics, bioinformatics, statistical genetics, low dose CT, child abuse, fluoroscopy

Education and Training:

• Medical School: University of California, San Diego
• PhD: University of California, San Diego
• Internship: Scripps Mercy Hospital, San Diego, California
• Residency: University of California, San Diego
• Fellowship: Boston Children's Hospital – Pediatric Radiology

• Incorporating Radiomics into Machine Learning Models to Predict Outcomes of Neuroblastoma.
  Journal of digital imaging 2022 Liu G, Poon M, Zapala MA, Temple WC, Vo KT, Matthay KK, Mitra D, Seo Y
• Rate of head ultrasound abnormalities at one month in very premature and extremely premature infants with normal initial screening ultrasound.
  Pediatric radiology 2022 Liu AR, Gano D, Li Y, Diwakar M, Courtier JL, Zapala MA
• Use of Digital Tomosynthesis in Assessing Accurate Medial Epicondyle Fracture Displacement as Compared With Conventional Radiography and Computed Tomography.
  Journal of pediatric orthopedics 2021 Livingston KS, Edwards EA, Griffin M, MacKenzie JD, Zapala MA
• Wilms Tumor (Nephroblastoma), Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
  Journal of the National Comprehensive Cancer Network : JNCCN 2021 Balis F, Green DM, Anderson C, Cook S, Dhillon J, Gow K, Hiniker S, Jasty-Rao R, Lin C, Lovvorn H, MacEwan I, Martinez-Agosto J, Mullen E, Murphy ES, Ranalli M, Rhee D, Rokitka D, Tracy EL, Vern-Gross…
• Association of image-defined risk factors with clinical features, histopathology, and outcomes in neuroblastoma.
  Cancer medicine 2020 Temple WC, Vo KT, Matthay KK, Balliu B, Coleman C, Michlitsch J, Phelps A, Behr S, Zapala MA
• The role of computed tomography and magnetic resonance imaging for preoperative pediatric cochlear implantation work-up in academic institutions.
  Cochlear implants international 2020 Ambrosio AA, Loundon N, Vinocur D, Kruk P, Le Pointe HD, Chalard F, Zapala M, Carvalho D
• Evaluating a Web-based Point-of-care Ultrasound Curriculum for the Diagnosis of Intussusception.
  AEM education and training 2020 Lin-Martore M, Olvera MP, Kornblith AE, Zapala M, Addo N, Lin M, Werner HC
• Monitoring Arteriovenous Malformation Response to Genotype-Targeted Therapy.
  Pediatrics 2020 Edwards EA, Phelps AS, Cooke D, Frieden IJ, Zapala MA, Fullerton HJ, Shimano KA
• Evaluating the Performance of Augmented Reality in Displaying Magnetic Resonance Imaging-Derived Three-Dimensional Holographic Models.
  Journal of medical imaging and radiation sciences 2019 Chang F, Laguna B, Uribe J, Vu L, Zapala MA, Devincent C, Courtier J
• Improved diagnostic confidence and accuracy of pediatric elbow fractures with digital tomosynthesis.
  Pediatric radiology 2019 Zapala MA, Livingston K, Bokhari D, Phelps AS, Courtier JL, Ma C, Seo Y, MacKenzie JD
• Digital tomosynthesis of the pediatric elbow.
  Pediatric radiology 2019 Zapala MA, Livingston K, Phelps AS, MacKenzie JD
• Assessment of quiet T2 weighted PROPELLER sequence in pediatric abdominal imaging.
  Clinical imaging 2018 Zaccagnino E, Devincent C, Leelakanok N, Phelps AS, Zapala M, Worters PW, Courtier J
• Intussusception: past, present and future.
  Pediatric radiology 2017 Edwards EA, Pigg N, Courtier J, Zapala MA, MacKenzie JD, Phelps AS
• Assessing 3D T2 FSE sequence for identification of the normal appendix: working toward a single-sequence MR appendicitis protocol.
  Emergency radiology 2017 Leelakanok N, Phelps AS, Zapala MA, Kato K, Ohliger M, Li Y, Courtier J
• Thoracic Neoplasms in Children: Contemporary Perspectives and Imaging Assessment.
  Radiologic clinics of North America 2017 Zapala MA, Ho-Fung VM, Lee EY
• Musculoskeletal Traumatic Injuries in Children: Characteristic Imaging Findings and Mimickers.
  Radiologic clinics of North America 2017 Ho-Fung VM, Zapala MA, Lee EY
• Incidental Findings on Pediatric Abdominal Magnetic Resonance Angiography.
  Academic radiology 2017 Leelakanok N, Zapala MA, Edwards EA, Phelps AS, Mackenzie JD, Courtier J
• Comparison of Mechanical Versus Hand Administration of IV Contrast Agents for Pediatric Pulmonary CT Angiography.
  AJR. American journal of roentgenology 2017 Zapala MA, Zurakowski D, Lee EY
• Magnetic resonance imaging of Müllerian duct anomalies in children.
  Pediatric radiology 2016 Li Y, Phelps A, Zapala MA, MacKenzie JD, MacKenzie TC, Courtier J
• Growth recovery lines are more common in infants at high vs. low risk for abuse.
  Pediatric radiology 2016 Zapala MA, Tsai A, Kleinman PK
• The radiogenomic risk score stratifies outcomes in a renal cell cancer phase 2 clinical trial.
  European radiology 2015 Jamshidi N, Jonasch E, Zapala M, Korn RL, Brooks JD, Ljungberg B, Kuo MD
• The Radiogenomic Risk Score: Construction of a Prognostic Quantitative, Noninvasive Image-based Molecular Assay for Renal Cell Carcinoma.
  Radiology 2015 Jamshidi N, Jonasch E, Zapala M, Korn RL, Aganovic L, Zhao H, Tumkur Sitaram R, Tibshirani RJ, Banerjee S, Brooks JD, Ljungberg B, Kuo MD
• Statistical properties of multivariate distance matrix regression for high-dimensional data analysis.
  Frontiers in genetics 2012 Zapala MA, Schork NJ
• Identification of polymorphisms associated with hypertriglyceridemia and prolonged survival induced by bexarotene in treating non-small cell lung cancer.
  Anticancer research 2011 Luo W, Schork NJ, Marschke KB, Ng SC, Hermann TW, Zhang J, Sanders JM, Tooker P, Malo N, Zapala MA, Dziewanowska ZE, Negro-Vilar A, Meglasson MD
• In silico QTL mapping of basal liver iron levels in inbred mouse strains.
  Physiological genomics 2010 McLachlan S, Lee SM, Steele TM, Hawthorne PL, Zapala MA, Eskin E, Schork NJ, Anderson GJ, Vulpe CD
• The effects of globin on microarray-based gene expression analysis of mouse blood.
  Mammalian genome : official journal of the International Mammalian Genome Society 2010 Winn ME, Zapala MA, Hovatta I, Risbrough VB, Lillie E, Schork NJ
• Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death.
  Physiological genomics 2007 Zhou D, Wang J, Zapala MA, Xue J, Schork NJ, Haddad GG
• Detecting genetic variation in microarray expression data.
  Genome research 2007 Greenhall JA, Zapala MA, Cáceres M, Libiger O, Barlow C, Schork NJ, Lockhart DJ
• Accommodating pathway information in expression quantitative trait locus analysis.
  Genomics 2007 Wessel J, Zapala MA, Schork NJ
• DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies.
  Genome biology 2007 Hovatta I, Zapala MA, Broide RS, Schadt EE, Libiger O, Schork NJ, Lockhart DJ, Barlow C
• Multivariate regression analysis of distance matrices for testing associations between gene expression patterns and related variables.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Zapala MA, Schork NJ
• Adult mouse brain gene expression patterns bear an embryologic imprint.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Zapala MA, Hovatta I, Ellison JA, Wodicka L, Del Rio JA, Tennant R, Tynan W, Broide RS, Helton R, Stoveken BS, Winrow C, Lockhart DJ, Reilly JF, Young WG, Bloom FE, Lockhart DJ, Barlow C
• Elevated gene expression levels distinguish human from non-human primate brains.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Cáceres M, Lachuer J, Zapala MA, Redmond JC, Kudo L, Geschwind DH, Lockhart DJ, Preuss TM, Barlow C
• Software and methods for oligonucleotide and cDNA array data analysis.
  Genome biology 2002 Zapala MA, Lockhart DJ, Pankratz DG, Garcia AJ, Barlow C, Lockhart DJ