Matthew Nix, PhD
Assistant Professor
Laboratory Medicine
School of Medicine

Publications (19)

Top publication keywords:
Static ElectricityMultiple MyelomaLeukemia, B-CellPrecursor B-Cell Lymphoblastic Leukemia-LymphomaAntigens, Differentiation, B-LymphocyteBurkitt LymphomaCamelids, New WorldAntigens, CDAntigens, CD19Immunotherapy, AdoptivePhosphatidylinositol PhosphatesReceptor, Melanocortin, Type 1Agouti Signaling Proteinbeta-DefensinsB-Lymphocytes

• Alternative target recognition elements for chimeric antigen receptor (CAR) T cells: beyond standard antibody fragments.
  Cytotherapy 2024 Nix MA, Wiita AP
• Framework humanization optimizes potency of anti-CD72 nanobody CAR-T cells for B-cell malignancies.
  Journal for immunotherapy of cancer 2023 Temple WC, Nix MA, Naik A, Izgutdina A, Huang BJ, Wicaksono G, Phojanakong P, Serrano JAC, Young EP, Ramos E, Salangsang F, Steri V, Xirenayi S, Hermiston M, Logan AC, Stieglitz E, Wiita AP
• Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target.
  Nature cancer 2023 Mandal K, Wicaksono G, Yu C, Adams JJ, Hoopmann MR, Temple WC, Izgutdina A, Escobar BP, Gorelik M, Ihling CH, Nix MA, Naik A, Xie WH, Hübner J, Rollins LA, Reid SM, Ramos E, Kasap C, Steri V, Serrano …
• The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance.
  Nature communications 2022 Ferguson ID, Patiño-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Nieves Vasquez W, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL…
• Author Correction: IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells.
  Nature 2021 Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP,…

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• Surface Proteomics Reveals CD72 as a Target for In Vitro-Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL.
  Cancer discovery 2021 Nix MA, Mandal K, Geng H, Paranjape N, Lin YT, Rivera JM, Marcoulis M, White KL, Whitman JD, Bapat SP, Parker KR, Ramirez J, Deucher A, Phojanokong P, Steri V, Fattahi F, Hann BC, Satpathy AT, Manglik…
• IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells.
  Nature 2020 Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP,…
• Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA
• Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
  bioRxiv : the preprint server for biology 2020 Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Lim SA, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Zhou XX, Hobman TC, Kortemme T, Wells JA
• Signalling input from divergent pathways subverts B cell transformation.
  Nature 2020 Chan LN, Murakami MA, Robinson ME, Caeser R, Sadras T, Lee J, Cosgun KN, Kume K, Khairnar V, Xiao G, Ahmed MA, Aghania E, Deb G, Hurtz C, Shojaee S, Hong C, Pölönen P, Nix MA, Chen Z, Chen CW, Chen J,…
• Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
  Leukemia 2020 Sarin V, Yu K, Ferguson ID, Gugliemini O, Nix MA, Hann B, Sirota M, Wiita AP
• Electrostatic Similarity Analysis of Human β-Defensin Binding in the Melanocortin System.
  Biophysical journal 2015 Nix MA, Kaelin CB, Palomino R, Miller JL, Barsh GS, Millhauser GL
• Molecular and functional analysis of human β-defensin 3 action at melanocortin receptors.
  Chemistry & biology 2013 Nix MA, Kaelin CB, Ta T, Weis A, Morton GJ, Barsh GS, Millhauser GL
• Defining MC1R regulation in human melanocytes by its agonist α-melanocortin and antagonists agouti signaling protein and β-defensin 3.
  The Journal of investigative dermatology 2012 Swope VB, Jameson JA, McFarland KL, Supp DM, Miller WE, McGraw DW, Patel MA, Nix MA, Millhauser GL, Babcock GF, Abdel-Malek ZA
• Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF.
  European journal of immunology 2011 Semple F, MacPherson H, Webb S, Cox SL, Mallin LJ, Tyrrell C, Grimes GR, Semple CA, Nix MA, Millhauser GL, Dorin JR
• New ligands for melanocortin receptors.
  International journal of obesity (2005) 2008 Kaelin CB, Candille SI, Yu B, Jackson P, Thompson DA, Nix MA, Binkley J, Millhauser GL, Barsh GS
• A -defensin mutation causes black coat color in domestic dogs.
  Science (New York, N.Y.) 2007 Candille SI, Kaelin CB, Cattanach BM, Yu B, Thompson DA, Nix MA, Kerns JA, Schmutz SM, Millhauser GL, Barsh GS
• Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?
  Proceedings of the National Academy of Sciences of the United States of America 1998 Tomiuk S, Hofmann K, Nix M, Zumbansen M, Stoffel W
• Ceramide-independent CD28 and TCR signaling but reduced IL-2 secretion in T cells of acid sphingomyelinase-deficient mice.
  European journal of immunology 1998 Stoffel B, Bauer P, Nix M, Deres K, Stoffel W