Matthew McCarroll, PhD
Assistant Researcher
Pharmaceutical Chemistry
School of Pharmacy

Education & Training

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• Phenotypic Psychoactive Drug Screening University of California San Francisco 04/2020
• Neuroactive Drug Discovery Harvard Medical School & Massachusetts General Hospital 08/2014
• PhD Developmental Neuroscience Oregon Health & Science University 01/2014

Publications (14)

Top publication keywords:
IbogaineReceptors, GABA-AConscious SedationFibroblast Growth Factor 10Zebrafish ProteinsBehavior, AnimalReceptors, SerotoninPaired Box Transcription FactorsPAX2 Transcription FactorCell-Penetrating PeptidesLarvaZebrafishPolypharmacyEctodermFibroblast Growth Factor 3

• Deep phenotypic profiling of neuroactive drugs in larval zebrafish.
  Nature communications 2024 Gendelev L, Taylor J, Myers-Turnbull D, Chen S, McCarroll MN, Arkin MR, Kokel D, Keiser MJ
• A Multimodal, In Vivo Approach for Assessing Structurally and Phenotypically Related Neuroactive Molecules.
  ACS chemical neuroscience 2024 McCarroll MN, Sisko E, Gong JH, Teng J, Taylor J, Myers-Turnbull D, Young D, Burley G, Pierce LX, Hibbs RE, Kokel D, Sello JK
• Hydroxyl-Rich Hydrophilic Endocytosis-Promoting Peptide with No Positive Charge.
  Journal of the American Chemical Society 2022 Wang S, Li Z, Aispuro D, Guevara N, Van Valkenburgh J, Chen B, Zhou X, McCarroll MN, Ji F, Cong X, Sarkar P, Chaudhuri R, Guo Z, Perkins NP, Shao S, Sello JK, Chen K, Xue M
• DaXi-high-resolution, large imaging volume and multi-view single-objective light-sheet microscopy.
  Nature methods 2022 Yang B, Lange M, Millett-Sikking A, Zhao X, Bragantini J, VijayKumar S, Kamb M, Gómez-Sjöberg R, Solak AC, Wang W, Kobayashi H, McCarroll MN, Whitehead LW, Fiolka RP, Kornberg TB, York AG, Royer LA
• A non-hallucinogenic psychedelic analogue with therapeutic potential.
  Nature 2020 Cameron LP, Tombari RJ, Lu J, Pell AJ, Hurley ZQ, Ehinger Y, Vargas MV, McCarroll MN, Taylor JC, Myers-Turnbull D, Liu T, Yaghoobi B, Laskowski LJ, Anderson EI, Zhang G, Viswanathan J, Brown BM, Tjia …

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• Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation.
  Nature communications 2019 McCarroll MN, Gendelev L, Kinser R, Taylor J, Bruni G, Myers-Turnbull D, Helsell C, Carbajal A, Rinaldi C, Kang HJ, Gong JH, Sello JK, Tomita S, Peterson RT, Keiser MJ, Kokel D
• Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.
  Nature chemical biology 2016 Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, Prinssen E, Roth BL, Keiser MJ…
• Leveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology.
  ACS chemical biology 2016 McCarroll MN, Gendelev L, Keiser MJ, Kokel D
• Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish.
  PloS one 2013 McCarroll MN, Nechiporuk AV
• Ear and Lateral Line of Vertebrates: Organisation and Development.
  eLS 2013 Molly Harding, Matthew McCarroll, Hillary McGraw, Alex Nechiporuk
• Graded levels of Pax2a and Pax8 regulate cell differentiation during sensory placode formation.
  Development (Cambridge, England) 2012 McCarroll MN, Lewis ZR, Culbertson MD, Martin BL, Kimelman D, Nechiporuk AV
• Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors.
  Molecular cancer 2009 Landais I, Hiddingh S, McCarroll M, Yang C, Sun A, Turker MS, Snyder JP, Hoatlin ME
• Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism.
  Journal of virology 2009 Douglas JL, Viswanathan K, McCarroll MN, Gustin JK, Früh K, Moses AV
• 115 HIV Vpu complexes with ßTrCP to direct the degradation of the virus release inhibitor BST-2 (Tetherin).
  JAIDS Journal of Acquired Immune Deficiency Syndromes 2009 Janet L Douglas, Kasinath Viswanathan, Matthew N McCarroll, Jean K Gustin, Klaus Fruh, Ashlee V Moses