Matthew Kan, MD, PhD
Assistant Professor
Pediatrics
School of Medicine
Awards
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- PSDP Fellowship, Pediatric Scientist Development Program, 2021-2023
Education & Training
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- Allergy and Immunology Fellowship UCSF 2023
- Pediatrics Residency UCSF 2021
- Ph.D. Department of Immunology Duke University 2016
- M.D. School of Medicine Duke University 2016
- B.A. Biology Harvard University 2007
Grants and Projects
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- Targeted gene correction in Artemis-deficient Severe Combined Immunodeficiency Syndrome, Pediatric Scientist Development Program/Eunice Kennedy Shriver National Institute of Child Health and Human Development, 2021-2023
- Sequence-based lymphocyte receptor diversity: a biomarker of immune reconstitution after hematopoietic cell transplantation for SCID, Primary Immune Deficiency Treatment Consortium, 2020-2021
- Sequencing T-cell receptor diversity after hematopoietic stem cell transplantation in Severe Combined Immunodeficiency (SCID) as an early biomarker for failure of bone marrow reconstitution, UCSF Benioff Children's Hospital, 2020-2021
Publications (19)
Top publication keywords:
Fever of Unknown OriginGene EditingCRISPR-Cas SystemsImmunologic FactorsInfectious Disease Transmission, Patient-to-ProfessionalPersonal Protective EquipmentClustered Regularly Interspaced Short Palindromic RepeatsRhabdomyolysisArginineMacrophages, AlveolarCRISPR-Associated ProteinsVascular RemodelingEndodeoxyribonucleasesDNA, AncientGenetic Diseases, Inborn
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The 10,000 Immunomes Project: Building a Resource for Human Immunology.
Cell reports 2018 Zalocusky KA, Kan MJ, Hu Z, Dunn P, Thomson E, Wiser J, Bhattacharya S, Butte AJ -
Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Kan MJ, Lee JE, Wilson JG, Everhart AL, Brown CM, Hoofnagle AN, Jansen M, Vitek MP, Gunn MD, Colton CA -
CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes.
Nucleic acids research 2024 Adler BA, Trinidad MI, Bellieny-Rabelo D, Zhang E, Karp HM, Skopintsev P, Thornton BW, Weissman RF, Yoon PH, Chen L, Hessler T, Eggers AR, Colognori D, Boger R, Doherty EE, Tsuchida CA, Tran RV, … -
Treatment of Genetic Diseases With CRISPR Genome Editing.
JAMA 2022 Kan MJ, Doudna JA -
Fever Without a Source in an Infant Due to Severe Acute Respiratory Syndrome Coronavirus-2.
Journal of the Pediatric Infectious Diseases Society 2021 Kan MJ, Grant LMC, Muña MA, Greenhow TL
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Nonclassical Monocytes Sense Hypoxia, Regulate Pulmonary Vascular Remodeling, and Promote Pulmonary Hypertension.
Journal of immunology (Baltimore, Md. : 1950) 2020 Yu YA, Malakhau Y, Yu CA, Phelan SJ, Cumming RI, Kan MJ, Mao L, Rajagopal S, Piantadosi CA, Gunn MD -
Tracing diagnosis trajectories over millions of patients reveal an unexpected risk in schizophrenia.
Scientific data 2019 Paik H, Kan MJ, Rappoport N, Hadley D, Sirota M, Chen B, Manber U, Cho SB, Butte AJ -
Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors.
Brain, behavior, and immunity 2018 Rivera PD, Hanamsagar R, Kan MJ, Tran PK, Stewart D, Jo YC, Gunn M, Bilbo SD -
The 10,000 Immunomes Project: Building a Resource for Human Immunology.
Cell reports 2018 Zalocusky KA, Kan MJ, Hu Z, Dunn P, Thomson E, Wiser J, Bhattacharya S, Butte AJ -
Whole-genome sequencing of Atacama skeleton shows novel mutations linked with dysplasia.
Genome research 2018 Bhattacharya S, Li J, Sockell A, Kan MJ, Bava FA, Chen SC, Ávila-Arcos MC, Ji X, Smith E, Asadi NB, Lachman RS, Lam HYK, Bustamante CD, Butte AJ, Nolan GP -
The 10,000 Immunomes Project: A Resource for Human Immunology.
Journal of Allergy and Clinical Immunology 2018 Matthew J. Kan, Kelly Zalocusky, Zicheng Hu, Patrick Dunn, Elizabeth Thomson, Jeffrey Wiser, Sanchita Bhattacharya, Atul Butte -
Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity.
Journal of controlled release : official journal of the Controlled Release Society 2017 Mastria EM, Cai LY, Kan MJ, Li X, Schaal JL, Fiering S, Gunn MD, Dewhirst MW, Nair SK, Chilkoti A -
C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration.
The American journal of pathology 2016 Rudemiller NP, Patel MB, Zhang JD, Jeffs AD, Karlovich NS, Griffiths R, Kan MJ, Buckley AF, Gunn MD, Crowley SD -
IMMUNE-MEDIATED NUTRIENT DEPRIVATION AND METABOLIC DISRUPTION IN AN ALZHEIMER'S DISEASE MOUSE MODEL.
Alzheimer's & Dementia 2016 Carol A. Colton, Ram S. Puranam, Michael P. Vitek, Matthew J. Kan -
A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues.
PloS one 2016 Yu YR, O'Koren EG, Hotten DF, Kan MJ, Kopin D, Nelson ER, Que L, Gunn MD -
Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.
Cell reports 2015 DeFalco T, Potter SJ, Williams AV, Waller B, Kan MJ, Capel B -
Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke.
PLoS genetics 2013 Keum S, Lee HK, Chu PL, Kan MJ, Huang MN, Gallione CJ, Gunn MD, Lo DC, Marchuk DA -
Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2013 Cain DW, O'Koren EG, Kan MJ, Womble M, Sempowski GD, Hopper K, Gunn MD, Kelsoe G -
iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity.
Journal of immunology (Baltimore, Md. : 1950) 2007 Meyer EH, Wurbel MA, Staton TL, Pichavant M, Kan MJ, Savage PB, DeKruyff RH, Butcher EC, Campbell JJ, Umetsu DT