Matt Durstenfeld, MD, MAS
Assistant Professor
Medicine
School of Medicine

As a team scientist, he loves working closely with mentors and collaborators from Cardiology, Infectious Diseases, and Pulmonology. His lab conducts echocardiography and cardiopulmonary exercise testing for multiple studies. His completed K12 career development award focused on mechanisms of cardiopulmonary phenotype Long COVID. His K23 Career Development Award is focused on cardiorespiratory fitness in HIV. He is also involved in clinical trials of lipid-lowering therapies in HIV, an immune-modulator for Long COVID, an over-encapsulated polypill for heart failure, cardiac rehabilitation for Long COVID, and a first-in-human COVID vaccine. He also conducts observational research to elucidate mechanisms of Long COVID and post-tuberculosis heart and lung disease and identify strategies to prevent atherosclerosis and heart failure among people with HIV. He was recently recognized with the ZSFG Department of Medicine Outstanding Early Career Investigator Award and as a World Heart Federation Emerging Leader.

• Association of Pre-COVID Fitness With Post-COVID Fitness and Long COVID in the Cooper Center Longitudinal Cohort Study.
  Journal of the American Heart Association 2025 Durstenfeld MS, Leonard D, Pettee Gabriel K, Barlow CE, Shuval K, Priest R, Pavlovic A, Radford NB, Berry JD, Peluso MJ, DeFina LF
• Prototyping and Manufacturing of Customized Over-Encapsulated Polypills for Heart Failure With Reduced Ejection Fraction in a Safety-Net Health Care System.
  Journal of cardiac failure 2025 Dejong C, Durstenfeld MS, Davis JD, Wang CS, Chen JC, Kazi DS, Hickey MD, Grochowski J, Steward WT, Riley ED, Zier LS, Moreau N, Huffman MD, Sandhu AT, Heidenreich PA, Agarwal A, Hsue PY
• Delivering guideline-directed medical therapy for heart failure with reduced ejection fraction as an over-encapsulated polypill: rationale and protocol for the COMBO-HF-X pilot crossover randomised clinical trial.
  BMJ open 2025 DeJong C, Durstenfeld MS, Davis JD, Wang CS, Riley ED, Huffman MD, Hickey MD, Shade SB, Chen JC, Kazi DS, Grochowski J, Steward WT, Zier LS, Moreau N, Sandhu AT, Heidenreich PA, Agarwal A, Hsue PY
• Direct-to-Physician Marketing and Uptake of Optimal Medical Therapy for Heart Failure With Reduced Ejection Fraction.
  JACC. Heart failure 2025 DeJong C, Inoue K, Durstenfeld MS, Agarwal A, Chen JC, Tseng CW, Dudley RA, Hsue PY, Kazi DS
• Multicenter study of heart failure phenotypes and physician-adjudicated causes in people with HIV.
  AIDS (London, England) 2025 Beydoun N, Nance RM, Durstenfeld MS, Hoffmann AP, Whitney BM, Burkholder GA, Health S, Hsue PY, Saag M, Delaney JA, Longenecker CT, Crane HM, Feinstein MJ
• Association of Cardiologist Clinic Visits With Cardiovascular Primary Prevention Outcomes Among People With HIV From Underrepresented Racial and Ethnic Groups in the Southern United States.
  Journal of the American Heart Association 2025 Durstenfeld MS, Hill CL, Clare RM, Chiswell K, Sanders G, Gray S, Vicini J, Marsolo K, Okeke NL, Meissner EG, Thomas KL, Morse CG, Bloomfield GS, Pettit AC, Longenecker CT
• Reducing readmissions in the safety net through AI and automation.
  The American journal of managed care 2025 Bennett DJ, Feng J, Goldman S, Kothari A, Gottlieb LM, Durstenfeld MS, Marks J, Ehrlich S, Davis J, Zier LS
• Methamphetamine-associated heart failure: Clinical characteristics and outcomes in a safety net population.
  Heart & lung : the journal of critical care 2024 Thakkar AB, Durstenfeld MS, Ma Y, Win S, Hsue PY
• HIV-Associated Heart Failure: Phenotypes and Clinical Outcomes in a Safety-Net Setting.
  Journal of the American Heart Association 2024 Durstenfeld MS, Thakkar A, Jeon D, Short R, Ma Y, Tseng ZH, Hsue PY
• Stakeholder Perspectives on a Heart Failure With Reduced Ejection Fraction Polypill: A Multi-Center Mixed Methods Study.
  Circulation. Cardiovascular quality and outcomes 2024 Chen JC, DeJong C, Agarwal M, Hairston AM, Durstenfeld MS, McKay V, Huffman MD, Hsue PY, Agarwal A
• Chronotropic Incompetence Among People With HIV Improves With Exercise Training in the Exercise for Healthy Aging Study.
  The Journal of infectious diseases 2024 Durstenfeld MS, Wilson MP, Jankowski CM, Ditzenberger GL, Longenecker CT, Erlandson KM
• Association of Cardiologist Clinic Visits with Cardiovascular Primary Prevention Outcomes Among People with HIV from Underrepresented Racial and Ethnic Groups in the Southern United States.
  medRxiv : the preprint server for health sciences 2024 Durstenfeld MS, Hill CL, Clare RM, Chiswell K, Sanders G, Gray S, Cooper L, Vicini J, Marsolo K, Okeke NL, Meissner EG, Thomas KL, Morse CG, Bloomfield GS, Pettit AC, Longenecker CT
• Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection.
  Science translational medicine 2024 Peluso MJ, Ryder D, Flavell RR, Wang Y, Levi J, LaFranchi BH, Deveau TM, Buck AM, Munter SE, Asare KA, Aslam M, Koch W, Szabo G, Hoh R, Deswal M, Rodriguez AE, Buitrago M, Tai V, Shrestha U, Lu S, …
• Advances in the Management of Cardiovascular Disease in the Setting of Human Immunodeficiency Virus.
  Infectious disease clinics of North America 2024 Durstenfeld MS, Hsue PY
• HIV-Associated Heart Failure: Phenotypes and Clinical Outcomes in a Safety-Net Setting.
  medRxiv : the preprint server for health sciences 2024 Durstenfeld MS, Thakkar A, Jeon D, Short R, Ma Y, Tseng ZH, Hsue PY
• Association Between Coronary Assessment in Heart Failure and Clinical Outcomes Within a Safety-Net Setting Using a Target Trial Emulation Observational Design.
  Circulation. Cardiovascular quality and outcomes 2024 Durstenfeld MS, Thakkar A, Ma Y, Zier LS, Davis JD, Hsue PY
• Long COVID and post-acute sequelae of SARS-CoV-2 pathogenesis and treatment: A Keystone Symposia report.
  Annals of the New York Academy of Sciences 2024 Durstenfeld MS, Weiman S, Holtzman M, Blish C, Pretorius R, Deeks SG
• Plasma-based antigen persistence in the post-acute phase of COVID-19.
  The Lancet. Infectious diseases 2024 Peluso MJ, Swank ZN, Goldberg SA, Lu S, Dalhuisen T, Borberg E, Senussi Y, Luna MA, Chang Song C, Clark A, Zamora A, Lew M, Viswanathan B, Huang B, Anglin K, Hoh R, Hsue PY, Durstenfeld MS, Spinelli …
• Association of nirmatrelvir for acute SARS-CoV-2 infection with subsequent Long COVID symptoms in an observational cohort study.
  Journal of medical virology 2024 Durstenfeld MS, Peluso MJ, Lin F, Peyser ND, Isasi C, Carton TW, Henrich TJ, Deeks SG, Olgin JE, Pletcher MJ, Beatty AL, Marcus GM, Hsue PY
• Plasma-based antigen persistence in the post-acute phase of SARS-CoV-2 infection.
  medRxiv : the preprint server for health sciences 2023 Peluso MJ, Swank ZN, Goldberg SA, Lu S, Dalhuisen T, Borberg E, Senussi Y, Luna MA, Song CC, Clark A, Zamora A, Lew M, Viswanathan B, Huang B, Anglin K, Hoh R, Hsue PY, Durstenfeld MS, Spinelli MA, …
• Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study.
  medRxiv : the preprint server for health sciences 2023 Durstenfeld MS, Wilson MP, Jankowski CM, Ditzenberger GL, Longenecker CT, Erlandson KM
• The breadth of the neutralizing antibody response to original SARS-CoV-2 infection is linked to the presence of Long COVID symptoms.
  Journal of medical virology 2023 Buck AM, Deitchman AN, Takahashi S, Lu S, Goldberg SA, Bodansky A, Kung A, Hoh R, Williams MC, Kerbleski M, Maison DP, Deveau TM, Munter SE, Lombardo J, Wrin T, Petropoulos CJ, Durstenfeld MS, Hsue PY…
• Association of SARS-CoV-2 Infection and Cardiopulmonary Long COVID With Exercise Capacity and Chronotropic Incompetence Among People With HIV.
  Journal of the American Heart Association 2023 Durstenfeld MS, Peluso MJ, Spinelli MA, Li D, Hoh R, Chenna A, Yee B, Winslow J, Petropoulos C, Gandhi M, Henrich TJ, Aras MA, Long CS, Deeks SG, Hsue PY
• Predictors of All-Cause 30-Day Readmissions in Patients with Heart Failure at an Urban Safety Net Hospital: The Importance of Social Determinants of Health and Mental Health.
  American journal of medicine open 2023 Steverson AB, Marano PJ, Chen C, Ma Y, Stern RJ, Feng J, Gennatas ED, Marks JD, Durstenfeld MS, Davis JD, Hsue PY, Zier LS
• Chest Pain, Bundle Branch Block, and Wide Complex Tachycardia: Is Three a Company or Crowd?
  Circulation 2023 Xiao SY, Goldschlager N, Durstenfeld MS
• Reduced Exercise Capacity, Chronotropic Incompetence, and Early Systemic Inflammation in Cardiopulmonary Phenotype Long Coronavirus Disease 2019.
  The Journal of infectious diseases 2023 Durstenfeld MS, Peluso MJ, Kaveti P, Hill C, Li D, Sander E, Swaminathan S, Arechiga VM, Lu S, Goldberg SA, Hoh R, Chenna A, Yee BC, Winslow JW, Petropoulos CJ, Kelly JD, Glidden DV, Henrich TJ, …
• Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19.
  medRxiv : the preprint server for health sciences 2023 Peluso MJ, Ryder D, Flavell R, Wang Y, Levi J, LaFranchi BH, Deveau TM, Buck AM, Munter SE, Asare KA, Aslam M, Koch W, Szabo G, Hoh R, Deswal M, Rodriguez A, Buitrago M, Tai V, Shrestha U, Lu S, …
• Cardiovascular health among persons with HIV without existing atherosclerotic cardiovascular disease.
  AIDS (London, England) 2023 McLaughlin MM, Durstenfeld MS, Gandhi M, Greene M, Ma Y, Beatty AL, Hsue PY
• Coronary Assessment in Heart Failure within a Safety-Net Setting: Disparities and Outcomes.
  medRxiv : the preprint server for health sciences 2023 Durstenfeld MS, Thakkar A, Ma Y, Zier LS, Davis JD, Hsue PY
• Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design.
  PloS one 2023 Horwitz LI, Thaweethai T, Brosnahan SB, Cicek MS, Fitzgerald ML, Goldman JD, Hess R, Hodder SL, Jacoby VL, Jordan MR, Krishnan JA, Laiyemo AO, Metz TD, Nichols L, Patzer RE, Sekar A, Singer NG, Stiles…
• Autoantigen profiling reveals a shared post-COVID signature in fully recovered and long COVID patients.
  JCI insight 2023 Bodansky A, Wang CY, Saxena A, Mitchell A, Kung AF, Takahashi S, Anglin K, Huang B, Hoh R, Lu S, Goldberg SA, Romero J, Tran B, Kirtikar R, Grebe H, So M, Greenhouse B, Durstenfeld MS, Hsue PY, …
• Association of SARS-CoV-2 Infection and Cardiopulmonary Long COVID with Exercise Capacity and Chronotropic Incompetence among People with HIV.
  medRxiv : the preprint server for health sciences 2023 Durstenfeld MS, Peluso MJ, Spinelli MA, Li D, Hoh R, Gandhi M, Henrich TJ, Aras MA, Long CS, Deeks SG, Hsue PY
• The Breadth of the Neutralizing Antibody Response to Original SARS-CoV-2 Infection is Linked to the Presence of Long COVID Symptoms.
  medRxiv : the preprint server for health sciences 2023 Buck AM, Deitchman AN, Takahashi S, Lu S, Goldberg SA, Hoh R, Williams MC, Kerbleski M, Deveau TM, Munter SE, Lombardo J, Wrin T, Petropoulos CJ, Durstenfeld MS, Hsue PY, Kelly JD, Greenhouse B, …
• Reduced exercise capacity, chronotropic incompetence, and early systemic inflammation in cardiopulmonary phenotype Long COVID.
  medRxiv : the preprint server for health sciences 2023 Durstenfeld MS, Peluso MJ, Kaveti P, Hill C, Li D, Sander E, Swaminathan S, Arechiga VM, Lu S, Goldberg SA, Hoh R, Chenna A, Yee BC, Winslow JW, Petropoulos CJ, Kelly JD, Glidden DV, Henrich TJ, …
• Autoantigen profiling reveals a shared post-COVID signature in fully recovered and Long COVID patients.
  medRxiv : the preprint server for health sciences 2023 Bodansky A, Wang CY, Saxena A, Mitchell A, Takahashi S, Anglin K, Huang B, Hoh R, Lu S, Goldberg SA, Romero J, Tran B, Kirtikar R, Grebe H, So M, Greenhouse B, Durstenfeld MS, Hsue PY, Hellmuth J, …
• Chronic viral coinfections differentially affect the likelihood of developing long COVID.
  The Journal of clinical investigation 2023 Peluso MJ, Deveau TM, Munter SE, Ryder D, Buck A, Beck-Engeser G, Chan F, Lu S, Goldberg SA, Hoh R, Tai V, Torres L, Iyer NS, Deswal M, Ngo LH, Buitrago M, Rodriguez A, Chen JY, Yee BC, Chenna A, …
• Factors Associated With Long COVID Symptoms in an Online Cohort Study.
  Open forum infectious diseases 2023 Durstenfeld MS, Peluso MJ, Peyser ND, Lin F, Knight SJ, Djibo A, Khatib R, Kitzman H, O'Brien E, Williams N, Isasi C, Kornak J, Carton TW, Olgin JE, Pletcher MJ, Marcus GM, Beatty AL
• Low Prevalence of Interferon α Autoantibodies in People Experiencing Symptoms of Post-Coronavirus Disease 2019 (COVID-19) Conditions, or Long COVID.
  The Journal of infectious diseases 2023 Peluso MJ, Mitchell A, Wang CY, Takahashi S, Hoh R, Tai V, Durstenfeld MS, Hsue PY, Kelly JD, Martin JN, Wilson MR, Greenhouse B, Deeks SG, DeRisi JL, Henrich TJ
• Association of Right Ventricular Dilation on Echocardiogram With In-Hospital Mortality Among Patients Hospitalized With COVID-19 Compared With Bacterial Pneumonia.
  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2022 Sun K, Cedarbaum E, Hill CA, Win S, Parikh NI, Hsue PY, Durstenfeld MS
• Factors Associated with Long Covid Symptoms in an Online Cohort Study.
  medRxiv : the preprint server for health sciences 2022 Durstenfeld MS, Peluso MJ, Peyser ND, Lin F, Knight SJ, Djibo A, Khatib R, Kitzman H, O'Brien E, Williams N, Isasi C, Kornak J, Carton TW, Olgin JE, Pletcher MJ, Marcus GM, Beatty AL
• Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults: A Systematic Review and Meta-analysis.
  JAMA network open 2022 Durstenfeld MS, Sun K, Tahir P, Peluso MJ, Deeks SG, Aras MA, Grandis DJ, Long CS, Beatty A, Hsue PY
• Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls.
  Journal of the Endocrine Society 2022 Parikh NI, Arowolo F, Durstenfeld MS, Nah G, Njoroge J, Vittinghoff E, Long CS, Ganz P, Pearce D, Hsue P, Wu AHS, Hajizadeh N, Liu KD, Lynch KL
• Impact of Pre-Existing Chronic Viral Infection and Reactivation on the Development of Long COVID.
  medRxiv : the preprint server for health sciences 2022 Peluso MJ, Deveau TM, Munter SE, Ryder D, Buck A, Beck-Engeser G, Chan F, Lu S, Goldberg SA, Hoh R, Tai V, Torres L, Iyer NS, Deswal M, Ngo LH, Buitrago M, Rodriguez A, Chen JY, Yee BC, Chenna A, …
• Postacute sequelae and adaptive immune responses in people with HIV recovering from SARS-COV-2 infection.
  AIDS (London, England) 2022 Peluso MJ, Spinelli MA, Deveau TM, Forman CA, Munter SE, Mathur S, Tang AF, Lu S, Goldberg SA, Arreguin MI, Hoh R, Tai V, Chen JY, Martinez EO, Yee BC, Chenna A, Winslow JW, Petropoulos CJ, Sette A, …
• Association of Right Ventricular Dilation and Dysfunction on Echocardiogram with In-Hospital Mortality Among Patients Hospitalized with COVID-19 Compared with Other Acute Respiratory Illness.
  medRxiv : the preprint server for health sciences 2022 Sun K, Cedarbaum E, Hill C, Win S, Parikh NI, Hsue PY, Durstenfeld MS
• Effect of Oral Nirmatrelvir on Long COVID Symptoms: 4 Cases and Rationale for Systematic Studies.
  Pathogens & immunity 2022 Peluso MJ, Anglin K, Durstenfeld MS, Martin JN, Kelly JD, Hsue PY, Henrich TJ, Deeks SG
• Cardiopulmonary exercise testing to evaluate post-acute sequelae of COVID-19 ("Long COVID"): a systematic review and meta-analysis.
  medRxiv : the preprint server for health sciences 2022 Durstenfeld MS, Sun K, Tahir PM, Peluso MJ, Deeks SG, Aras MA, Grandis DJ, Long CS, Beatty A, Hsue PY
• Plasma Markers of Neurologic Injury and Inflammation in People With Self-Reported Neurologic Postacute Sequelae of SARS-CoV-2 Infection.
  Neurology(R) neuroimmunology & neuroinflammation 2022 Peluso MJ, Sans HM, Forman CA, Nylander AN, Ho HE, Lu S, Goldberg SA, Hoh R, Tai V, Munter SE, Chenna A, Yee BC, Winslow JW, Petropoulos CJ, Martin JN, Kelly JD, Durstenfeld MS, Hsue PY, Hunt PW, …
• Sex-specific performance of the ASCVD pooled cohort equation risk calculator as a correlate of coronary artery calcium in Kampala, Uganda.
  International journal of cardiology. Cardiovascular risk and prevention 2022 Kentoffio K, Durstenfeld MS, Siedner MJ, Kityo C, Erem G, Ssinabulya I, Ghoshhajra B, Bittencourt MS, Longenecker CT
• Outcomes in Patients With Heart Failure Using Cocaine.
  The American journal of cardiology 2022 Garry JD, Thakkar AB, Durstenfeld MS, Ma Y, Win S, Hsue PY
• Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infection.
  JCI insight 2022 Durstenfeld MS, Peluso MJ, Kelly JD, Win S, Swaminathan S, Li D, Arechiga VM, Zepeda V, Sun K, Shao S, Hill C, Arreguin MI, Lu S, Hoh R, Tai V, Chenna A, Yee BC, Winslow JW, Petropoulos CJ, Kornak J, …
• HIV and SARS-CoV-2 biochemical interactions may not explain clinical outcomes among adults hospitalized with COVID-19 co-infected with HIV: authors' reply.
  AIDS (London, England) 2022 Durstenfeld MS, Hsue PY
• Association of HIV infection with outcomes among adults hospitalized with COVID-19.
  AIDS (London, England) 2022 Durstenfeld MS, Sun K, Ma Y, Rodriguez F, Secemsky EA, Parikh RV, Hsue PY
• Findings From Mayo Clinic's Post-COVID Clinic: PASC Phenotypes Vary by Sex and Degree of IL-6 Elevation.
  Mayo Clinic proceedings 2022 Durstenfeld MS, Hsue PY, Peluso MJ, Deeks SG
• Persistence, Magnitude, and Patterns of Postacute Symptoms and Quality of Life Following Onset of SARS-CoV-2 Infection: Cohort Description and Approaches for Measurement.
  Open forum infectious diseases 2021 Peluso MJ, Kelly JD, Lu S, Goldberg SA, Davidson MC, Mathur S, Durstenfeld MS, Spinelli MA, Hoh R, Tai V, Fehrman EA, Torres L, Hernandez Y, Williams MC, Arreguin MI, Ngo LH, Deswal M, Munter SE, …
• Markers of Immune Activation and Inflammation in Individuals With Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
  The Journal of infectious diseases 2021 Peluso MJ, Lu S, Tang AF, Durstenfeld MS, Ho HE, Goldberg SA, Forman CA, Munter SE, Hoh R, Tai V, Chenna A, Yee BC, Winslow JW, Petropoulos CJ, Greenhouse B, Hunt PW, Hsue PY, Martin JN, Daniel Kelly …
• Mechanisms and primary prevention of atherosclerotic cardiovascular disease among people living with HIV.
  Current opinion in HIV and AIDS 2021 Durstenfeld MS, Hsue PY
• Impact of HIV Infection on COVID-19 Outcomes Among Hospitalized Adults in the U.S.
  medRxiv : the preprint server for health sciences 2021 Durstenfeld MS, Sun K, Ma Y, Rodriguez F, Secemsky EA, Parikh RV, Hsue PY
• Rapid implementation of a cohort for the study of post-acute sequelae of SARS-CoV-2 infection/COVID-19.
  medRxiv : the preprint server for health sciences 2021 Peluso MJ, Kelly JD, Lu S, Goldberg SA, Davidson MC, Mathur S, Durstenfeld MS, Spinelli MA, Hoh R, Tai V, Fehrman EA, Torres L, Hernandez Y, Williams MC, Arreguin MI, Bautista JA, Ngo LH, Deswal M, …
• An Unusual, Reversible Cause of Acute High-Output Heart Failure Complicated by Refractory Shock.
  Circulation 2020 Durstenfeld MS, Hsue PY
• Swimming With Sharks: Teaching Residents Value-Based Medicine and Quality Improvement Through Resident-Pitched Projects.
  Journal of graduate medical education 2020 Durstenfeld MS, Statman S, Carney K, Cohan B, Bosworth B, Hauck K, Dikman A
• Mineralocorticoid receptor antagonist use after hospitalization of patients with heart failure and post-discharge outcomes: a single-center retrospective cohort study.
  BMC cardiovascular disorders 2019 Durstenfeld MS, Katz SD, Park H, Blecker S
• The Swiss Cheese Conference: Integrating and Aligning Quality Improvement Education With Hospital Patient Safety Initiatives.
  American journal of medical quality : the official journal of the American College of Medical Quality 2019 Durstenfeld MS, Statman S, Dikman A, Fallahi A, Fang C, Volpicelli FM, Hochman KA
• Racial and Ethnic Differences in Heart Failure Readmissions and Mortality in a Large Municipal Healthcare System.
  JACC. Heart failure 2016 Durstenfeld MS, Ogedegbe O, Katz SD, Park H, Blecker S
• Physician predictions of length of stay of patients admitted with heart failure.
  Journal of hospital medicine 2016 Durstenfeld MS, Saybolt MD, Praestgaard A, Kimmel SE