Matilda Chan, MD, PhD
Professor
Ophthalmology
School of Medicine

Matilda Chan is a cornea specialist at the F.I. Proctor Foundation. Her clinical expertise is the diagnosis and management of patients with corneal and ocular surface diseases. Her basic and translational research program focuses on understanding the cellular and molecular responses to corneal injury.

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California 2018
• M.D., Ph.D. School of Medicine Keck/University of Southern California 2002
• Clinical Fellowship School of Medicine University of California, San Francisco

Websites

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• Clinical Profile at UCSF Medical Center (ucsfhealth.org)
• My Lab Website (vision.ucsf.edu)

Grants and Projects

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• Analysis of chemical modulators for corneal endothelial dystrophies, NIH, 2021-2026
• , Research to Prevent Blindness (RPB), 2016-2019
• Regulation of Corneal Repair by Metalloproteinases, NIH, 2013-2019
• The Role of Extracelluar Enzymes in Regulating Corneal Repair, NIH, 2008-2014

Publications (35)

Top publication keywords:
Keratoplasty, PenetratingChemokine CCL2Wound HealingFuchs' Endothelial DystrophyMatrix MetalloproteinasesBurns, ChemicalCorneal Dystrophies, HereditaryEpithelium, CornealKeratitisCorneal NeovascularizationDNA MethylationEye Infections, BacterialMatrix Metalloproteinase 12CorneaCorneal Injuries

• Characterization of Polymicrobial and Antibiotic-Resistant Infectious Keratitis in a County Hospital Setting.
  Cornea open 2023 Chan L, Lopez JB, Saifee M, Padmanabhan S, Chan MF, Yung M
• Novel Mechanisms Guide Innovative Molecular-Based Therapeutic Strategies for Fuchs Endothelial Corneal Dystrophy.
  Cornea 2023 Chan MF, Pan P, Wolfreys FD
• Isolated Ocular Mpox without Skin Lesions, United States.
  Emerging infectious diseases 2023 Nguyen MT, Mentreddy A, Schallhorn J, Chan M, Aung S, Doernberg SB, Babik J, Miles K, Yang K, Lydon E, Minter DJ, Gonzales J, Shantha J, Doan T, Seitzman GD
• Disrupting autorepression circuitry generates ''open-loop lethality'' to yield escape-resistant antiviral agents.
  Cell 2023 Chaturvedi S, Pablo M, Wolf M, Rosas-Rivera D, Calia G, Kumar AJ, Vardi N, Du K, Glazier J, Ke R, Chan MF, Perelson AS, Weinberger LS
• Characterization of Infectious Keratitis in Opioid Users in a County Hospital Setting.
  Cornea open 2023 Lopez JB, Chan L, Saifee M, Seitzman GD, Yung M, Chan MF

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• Ocular Rosacea microBiome Study (ORBS)-sub-microbial versus antibiotic dosing of doxycycline versus placebo in treatment of symptomatic ocular rosacea: study protocol for a parallel-arm randomized clinical trial.
  Trials 2022 Mahmud H, Keenan JD, Gonzales J, Schallhorn J, Chan M, Arnold B, Cavallino V, Lietman TM, Doan T, Seitzman GD
• Risk Factors Predicting Loss to Follow-Up, Medication Noncompliance, and Poor Visual Outcomes Among Patients With Infectious Keratitis at a Public County Hospital.
  Cornea 2022 Lopez JB, Chan L, Saifee M, Padmanabhan S, Yung M, Chan MF
• Disrupting autorepression circuitry generates "open-loop lethality" to yield escape-resistant antiviral agents.
  Cell 2022 Chaturvedi S, Pablo M, Wolf M, Rosas-Rivera D, Calia G, Kumar AJ, Vardi N, Du K, Glazier J, Ke R, Chan MF, Perelson AS, Weinberger LS
• Characterization of Recruited Mononuclear Phagocytes following Corneal Chemical Injury.
  International journal of molecular sciences 2022 Lamy R, Wolf M, Bispo C, Clay SM, Zheng S, Wolfreys F, Pan P, Chan MF
• Spontaneous hyphema in the setting of COVID-19 pneumonia.
  American journal of ophthalmology case reports 2022 Chiang J, Chan L, Stallworth JY, Chan MF
• Pulsating Cilioretinal Artery From Ocular Hypertension.
  JAMA ophthalmology 2021 Liu Y, Chan MF, Stewart JM
• Corneal Repair Models in Mice: Epithelial/Mechanical Versus Stromal/Chemical Injuries.
  Methods in molecular biology (Clifton, N.J.) 2021 Pan P, Chan MF
• Author Correction: Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy.
  Scientific reports 2020 Pan P, Weisenberger DJ, Zheng S, Wolf M, Hwang DG, Rose-Nussbaumer JR, Jurkunas UV, Chan MF
• Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy.
  Scientific reports 2019 Pan P, Weisenberger DJ, Zheng S, Wolf M, Hwang DG, Rose-Nussbaumer JR, Jurkunas UV, Chan MF
• MMP12 Inhibits Corneal Neovascularization and Inflammation through Regulation of CCL2.
  Scientific reports 2019 Wolf M, Clay SM, Zheng S, Pan P, Chan MF
• Overexpression of MMPs in Corneas Requiring Penetrating and Deep Anterior Lamellar Keratoplasty.
  Investigative ophthalmology & visual science 2019 Wolf M, Clay SM, Oldenburg CE, Rose-Nussbaumer J, Hwang DG, Chan MF
• Epidemiology of uveitis in a US population-based study.
  Journal of ophthalmic inflammation and infection 2018 González MM, Solano MM, Porco TC, Oldenburg CE, Acharya NR, Lin SC, Chan MF
• Effects of MMP12 on cell motility and inflammation during corneal epithelial repair.
  Experimental eye research 2017 Wolf M, Maltseva I, Clay SM, Pan P, Gajjala A, Chan MF
• Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy.
  PloS one 2017 Khuc E, Bainer R, Wolf M, Clay SM, Weisenberger DJ, Kemmer J, Weaver VM, Hwang DG, Chan MF
• sFlt Multivalent Conjugates Inhibit Angiogenesis and Improve Half-Life In Vivo.
  PloS one 2016 Altiok EI, Browne S, Khuc E, Moran EP, Qiu F, Zhou K, Santiago-Ortiz JL, Ma JX, Chan MF, Healy KE
• Metalloproteinases: a Functional Pathway for Myeloid Cells.
  Microbiology spectrum 2016 Chou J, Chan MF, Werb Z
• Animal Models of Corneal Injury.
  Bio-protocol 2015 Chan MF, Werb Z
• Confocal Imaging of Myeloid Cells in the Corneal Stroma of Live Mice.
  Bio-protocol 2015 Chan MF, Werb Z
• The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair.
  PloS one 2013 Maltseva I, Chan M, Kalus I, Dierks T, Rosen SD
• Protective effects of matrix metalloproteinase-12 following corneal injury.
  Journal of cell science 2013 Chan MF, Li J, Bertrand A, Casbon AJ, Lin JH, Maltseva I, Werb Z
• The clinical differentiation of bacterial and fungal keratitis: a photographic survey.
  Investigative ophthalmology & visual science 2012 Dalmon C, Porco TC, Lietman TM, Prajna NV, Prajna L, Das MR, Kumar JA, Mascarenhas J, Margolis TP, Whitcher JP, Jeng BH, Keenan JD, Chan MF, McLeod SD, Acharya NR
• Membrane array analysis of tear proteins in ocular cicatricial pemphigoid.
  Optometry and vision science : official publication of the American Academy of Optometry 2011 Chan MF, Sack R, Quigley DA, Sathe S, Vijmasi T, Li S, Holsclaw D, Strauss EC, McNamara NA
• Microbiological cure times in acanthamoeba keratitis.
  Eye (London, England) 2011 Oldenburg CE, Keenan JD, Cevallos V, Chan MF, Acharya NR, Gaynor BD, McLeod SD, Esterberg EJ, Porco TC, Lietman TM
• Late varicella-zoster virus dendriform keratitis in patients with histories of herpes zoster ophthalmicus.
  American journal of ophthalmology 2009 Hu AY, Strauss EC, Holland GN, Chan MF, Yu F, Margolis TP
• Cicatrising conjunctivitis due to paraneoplastic pemphigoid.
  The British journal of ophthalmology 2007 Rutar T, Chan MF, Acharya NR, Naseri A
• Interleukin-6 protects retinal ganglion cells from pressure-induced death.
  Investigative ophthalmology & visual science 2006 Sappington RM, Chan M, Calkins DJ
• Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements.
  Molecular and cellular biology 2002 Liang G, Chan MF, Tomigahara Y, Tsai YC, Gonzales FA, Li E, Laird PW, Jones PA
• Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells.
  Molecular and cellular biology 2001 Chan MF, van Amerongen R, Nijjar T, Cuppen E, Jones PA, Laird PW
• Relationship between transcription and DNA methylation.
  Current topics in microbiology and immunology 2000 Chan MF, Liang G, Jones PA
• Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations.
  Cancer research 1996 Simoneau AR, Spruck CH, Gonzalez-Zulueta M, Gonzalgo ML, Chan MF, Tsai YC, Dean M, Steven K, Horn T, Jones PA