Matija Peterlin, MD
Professor Emeritus
Medicine
School of Medicine

Grants and Projects

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• HARC Center: HIV Accessory and Regulatory Complexes, NIH, 2007-2022
• TAT Transactivation, NIH, 2016-2021
• Martin Delaney Collaboratory to Eradicate HIV-1 Infection, NIH, 2011-2016
• TAT Transactivation, NIH, 2001-2015
• Molecular Mechanisms of HIV Post-Integration Latency, NIH, 2004-2010
• CIITA and MHC II Transcription, NIH, 2003-2007
• Mechanism of HIV 1 Nef Action, NIH, 2002-2006
• Conference of Molecular Biology of Hiv, NIH, 1996-1997
• Bls Ii--Defective Proteins and Genes, NIH, 1990-1995
• U.c.s.f. Multipurpose Arthritis Center, NIH, 1977-1988
• Intestinal Immune Response: Regulation and Mechanisms, NIH, 1983-1986

Publications (15)

Top publication keywords:
Transcriptional ActivationPositive Transcriptional Elongation Factor BF-Box ProteinsUbiquitinationExodeoxyribonucleasesCyclin-Dependent KinasesProto-Oncogene Proteins c-fosNuclear ProteinsTranscription Factor RelARNA Polymerase IITranscription, GeneticRNA, Small NuclearHistone Deacetylase InhibitorsRNA 3' End ProcessingRibonucleoproteins, Small Nuclear

• Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb.
  eLife 2021 Huang F, Nguyen TT, Echeverria I, Rakesh R, Cary DC, Paculova H, Sali A, Weiss A, Peterlin BM, Fujinaga K
• Bromodomain-containing protein 4-independent transcriptional activation by autoimmune regulator (AIRE) and NF-κB.
  The Journal of biological chemistry 2018 Huang F, Shao W, Fujinaga K, Peterlin BM
• Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA.
  PloS one 2018 Ferdin J, Goricar K, Dolžan V, Plemenitaš A, Martin JN, Peterlin BM, Deeks SG, Lenassi M
• Nef is secreted in exosomes from Nef.GFP-expressing and HIV-1-infected human astrocytes.
  Journal of neurovirology 2017 Pužar Dominkuš P, Ferdin J, Plemenitaš A, Peterlin BM, Lenassi M
• A Truncated Nef Peptide from SIVcpz Inhibits the Production of HIV-1 Infectious Progeny.
  Viruses 2016 Sabino Cunha M, Lima Sampaio T, Peterlin BM, Jesus da Costa L

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• FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).
  The Journal of biological chemistry 2016 Shao W, Zumer K, Fujinaga K, Peterlin BM
• CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing.
  Cell host & microbe 2015 Pak V, Eifler TT, Jäger S, Krogan NJ, Fujinaga K, Peterlin BM
• Visualization of positive transcription elongation factor b (P-TEFb) activation in living cells.
  The Journal of biological chemistry 2014 Fujinaga K, Luo Z, Schaufele F, Peterlin BM
• Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts.
  Molecular and cellular biology 2014 Eifler TT, Shao W, Bartholomeeusen K, Fujinaga K, Jäger S, Johnson JR, Luo Z, Krogan NJ, Peterlin BM
• Reactivation of latent HIV-1 by new semi-synthetic ingenol esters.
  Virology 2014 Pandeló José D, Bartholomeeusen K, da Cunha RD, Abreu CM, Glinski J, da Costa TB, Bacchi Rabay AF, Pianowski Filho LF, Dudycz LW, Ranga U, Peterlin BM, Pianowski LF, Tanuri A, Aguiar RS
• Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcription.
  The Journal of biological chemistry 2013 Bartholomeeusen K, Fujinaga K, Xiang Y, Peterlin BM
• Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G.
  PLoS pathogens 2012 Stanley DJ, Bartholomeeusen K, Crosby DC, Kim DY, Kwon E, Yen L, Cartozo NC, Li M, Jäger S, Mason-Herr J, Hayashi F, Yokoyama S, Krogan NJ, Harris RS, Peterlin BM, Gross JD
• 7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription.
  Wiley interdisciplinary reviews. RNA 2011 Peterlin BM, Brogie JE, Price DH
• Transcription elongation takes central stage: the P-TEFb connection.
  Cell cycle (Georgetown, Tex.) 2010 Peterlin BM
• Controlling the elongation phase of transcription with P-TEFb.
  Molecular cell 2006 Peterlin BM, Price DH