Massimo Scanziani, PhD
Professor
Physiology
School of Medicine

Grants and Projects

Show all (7) Hide

• Mapping Retinotectal Circuits for Visual-evoked Innate Behaviors, NIH, 2021-2026
• Understanding V1 circuit dynamics and computations, NIH, 2018-2024
• Neural Circuits for the Cortical Control of the Optokinetic Reflex, NIH, 2016-2021
• Classifying Cortical Neurons by Correlating Transcriptome with Function, NIH, 2014-2017
• Role of CREST in Cortical Development and Plasticity, NIH, 2003-2014
• Cortical Feedback Inhibition, NIH, 2004-2010
• Dynamic Properties of Elementary Inhibitory Circuits, NIH, 2004-2010

Publications (85)

Top publication keywords:
ThalamusSaccadesVisual PathwaysSynapsesSuperior ColliculiNeural InhibitionInterneuronsPhotic StimulationSynaptic TransmissionNeuronsPyramidal CellsAction PotentialsHead MovementsSomatosensory CortexVisual Cortex

• The Logic of Thalamic Inputs onto the Molecular Taxonomy of Cortical Neurons Reveals a Visual Hierarchy.
  bioRxiv : the preprint server for biology 2026 Ge X, Wei X, Ruan B, Wu QY, Chang S, Tsai N, Zhang S, Duan X, Scanziani M
• Vision shapes neural maps of space through an ancient midbrain pathway.
  bioRxiv : the preprint server for biology 2026 Brenner JM, Ruediger S, Wilhite C, Regalado JM, Senzai Y, Voskobiynyk Y, Paz JT, Scanziani M, Beltramo R
• Inter- and intrahemispheric sources of vestibular signals to V1.
  Proceedings of the National Academy of Sciences of the United States of America 2025 Bouvier G, Sanzeni A, Hamada E, Brunel N, Scanziani M
• A Scalable Fishbone Nanowire Array (FINE) for 3D Quasi-Intracellular Recording in Intact Brains.
  Advanced materials (Deerfield Beach, Fla.) 2025 Tchoe Y, Lee J, Tonsfeldt KJ, Wu T, Cleary DR, U HS, Liu R, Bouvier G, Vatsyayan R, Bourhis AM, Lee SH, Halgren E, Galton I, Scanziani M, Dayeh SA
• Inter- and Intrahemispheric Sources of Vestibular Signals to V1.
  bioRxiv : the preprint server for biology 2024 Bouvier G, Sanzeni A, Hamada E, Brunel N, Scanziani M

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• Contextual modulation emerges by integrating feedforward and feedback processing in mouse visual cortex.
  Cell reports 2024 Di Santo S, Dipoppa M, Keller A, Roth M, Scanziani M, Miller KD
• The brain simulates actions and their consequences during REM sleep.
  bioRxiv : the preprint server for biology 2024 Senzai Y, Scanziani M
• High-throughput volumetric mapping of synaptic transmission.
  Nature methods 2024 Chen W, Ge X, Zhang Q, Natan RG, Fan JL, Scanziani M, Ji N
• A genetically defined tecto-thalamic pathway drives a system of superior-colliculus-dependent visual cortices.
  Neuron 2023 Brenner JM, Beltramo R, Gerfen CR, Ruediger S, Scanziani M
• Brain State-Dependent Modulation of Thalamic Visual Processing by Cortico-Thalamic Feedback.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Reinhold K, Resulaj A, Scanziani M
• Publisher Correction: Distinguishing externally from saccade-induced motion in visual cortex.
  Nature 2022 Miura SK, Scanziani M
• Distinguishing externally from saccade-induced motion in visual cortex.
  Nature 2022 Miura SK, Scanziani M
• A cognitive process occurring during sleep is revealed by rapid eye movements.
  Science (New York, N.Y.) 2022 Senzai Y, Scanziani M
• How Cortical Circuits Implement Cortical Computations: Mouse Visual Cortex as a Model.
  Annual review of neuroscience 2021 Niell CM, Scanziani M
• A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex.
  Neuron 2020 Keller AJ, Dipoppa M, Roth MM, Caudill MS, Ingrosso A, Miller KD, Scanziani M
• Learning speed and detection sensitivity controlled by distinct cortico-fugal neurons in visual cortex.
  eLife 2020 Ruediger S, Scanziani M
• Head Movements Control the Activity of Primary Visual Cortex in a Luminance-Dependent Manner.
  Neuron 2020 Bouvier G, Senzai Y, Scanziani M
• Feedback generates a second receptive field in neurons of the visual cortex.
  Nature 2020 Keller AJ, Roth MM, Scanziani M
• Multicolor Polymeric Nanoparticle Neuronal Tracers.
  ACS central science 2020 Zang N, Issa JB, Ditri TB, Bortone DS, Touve MA, Rush AM, Scanziani M, Dombeck DA, Gianneschi NC
• Reorganization of Recurrent Layer 5 Corticospinal Networks Following Adult Motor Training.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Biane JS, Takashima Y, Scanziani M, Conner JM, Tuszynski MH
• A collicular visual cortex: Neocortical space for an ancient midbrain visual structure.
  Science (New York, N.Y.) 2019 Beltramo R, Scanziani M
• Visual physiology of the layer 4 cortical circuit in silico.
  PLoS computational biology 2018 Arkhipov A, Gouwens NW, Billeh YN, Gratiy S, Iyer R, Wei Z, Xu Z, Abbasi-Asl R, Berg J, Buice M, Cain N, da Costa N, de Vries S, Denman D, Durand S, Feng D, Jarsky T, Lecoq J, Lee B, Li L, Mihalas S, …
• Publisher Correction: Tuned thalamic excitation is amplified by visual cortical circuits.
  Nature neuroscience 2018 Lien AD, Scanziani M
• Cortical direction selectivity emerges at convergence of thalamic synapses.
  Nature 2018 Lien AD, Scanziani M
• First spikes in visual cortex enable perceptual discrimination.
  eLife 2018 Resulaj A, Ruediger S, Olsen SR, Scanziani M
• Cortico-fugal output from visual cortex promotes plasticity of innate motor behaviour.
  Nature 2016 Liu BH, Huberman AD, Scanziani M
• Thalamocortical Projections onto Behaviorally Relevant Neurons Exhibit Plasticity during Adult Motor Learning.
  Neuron 2016 Biane JS, Takashima Y, Scanziani M, Conner JM, Tuszynski MH
• Distinct recurrent versus afferent dynamics in cortical visual processing.
  Nature neuroscience 2015 Reinhold K, Lien AD, Scanziani M
• An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo.
  Scientific reports 2015 Wietek J, Beltramo R, Scanziani M, Hegemann P, Oertner TG, Wiegert JS
• Motor cortex maturation is associated with reductions in recurrent connectivity among functional subpopulations and increases in intrinsic excitability.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Biane JS, Scanziani M, Tuszynski MH, Conner JM
• Equalizing excitation-inhibition ratios across visual cortical neurons.
  Nature 2014 Xue M, Atallah BV, Scanziani M
• Atallah et al. reply.
  Nature 2014 Atallah BV, Scanziani M, Carandini M
• Translaminar inhibitory cells recruited by layer 6 corticothalamic neurons suppress visual cortex.
  Neuron 2014 Bortone DS, Olsen SR, Scanziani M
• The contribution of synaptic location to inhibitory gain control in pyramidal cells.
  Physiological reports 2013 Pouille F, Watkinson O, Scanziani M, Trevelyan AJ
• Tuned thalamic excitation is amplified by visual cortical circuits.
  Nature neuroscience 2013 Lien AD, Scanziani M
• Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons.
  Nature neuroscience 2013 Pfeffer CK, Xue M, He M, Huang ZJ, Scanziani M
• New insights into the classification and nomenclature of cortical GABAergic interneurons.
  Nature reviews. Neuroscience 2013 DeFelipe J, López-Cruz PL, Benavides-Piccione R, Bielza C, Larrañaga P, Anderson S, Burkhalter A, Cauli B, Fairén A, Feldmeyer D, Fishell G, Fitzpatrick D, Freund TF, González-Burgos G, Hestrin S, …
• A neural circuit for spatial summation in visual cortex.
  Nature 2012 Adesnik H, Bruns W, Taniguchi H, Huang ZJ, Scanziani M
• The information content of physiological and epileptic brain activity.
  The Journal of physiology 2012 Trevelyan AJ, Bruns W, Mann EO, Crepel V, Scanziani M
• Gain control by layer six in cortical circuits of vision.
  Nature 2012 Olsen SR, Bortone DS, Adesnik H, Scanziani M
• Parvalbumin-expressing interneurons linearly transform cortical responses to visual stimuli.
  Neuron 2012 Atallah BV, Bruns W, Carandini M, Scanziani M
• In vivo Labeling of Constellations of Functionally Identified Neurons for Targeted in vitro Recordings.
  Frontiers in neural circuits 2011 Lien AD, Scanziani M
• How inhibition shapes cortical activity.
  Neuron 2011 Isaacson JS, Scanziani M
• Multiple clusters of release sites formed by individual thalamic afferents onto cortical interneurons ensure reliable transmission.
  Neuron 2011 Bagnall MW, Hull C, Bushong EA, Ellisman MH, Scanziani M
• Linking neuronal ensembles by associative synaptic plasticity.
  PloS one 2011 Yuan Q, Isaacson JS, Scanziani M
• Pyramidal cells in piriform cortex receive convergent input from distinct olfactory bulb glomeruli.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Apicella A, Yuan Q, Scanziani M, Isaacson JS
• Lateral competition for cortical space by layer-specific horizontal circuits.
  Nature 2010 Adesnik H, Scanziani M
• Input normalization by global feedforward inhibition expands cortical dynamic range.
  Nature neuroscience 2009 Pouille F, Marin-Burgin A, Adesnik H, Atallah BV, Scanziani M
• Electrophysiology in the age of light.
  Nature 2009 Scanziani M, Häusser M
• Neocortical disynaptic inhibition requires somatodendritic integration in interneurons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Hull C, Adesnik H, Scanziani M
• Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Hull C, Isaacson JS, Scanziani M
• Instantaneous modulation of gamma oscillation frequency by balancing excitation with inhibition.
  Neuron 2009 Atallah BV, Scanziani M
• Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis.
  Nature neuroscience 2008 Glickfeld LL, Roberts JD, Somogyi P, Scanziani M
• Complementary modulation of somatic inhibition by opioids and cannabinoids.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Glickfeld LL, Atallah BV, Scanziani M
• Erratum: Corrigendum: Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex.
  Nature Neuroscience 2007 Christoph Kapfer, Lindsey L Glickfield, Bassam V Atallah, Massimo Scanziani
• Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex.
  Nature neuroscience 2007 Kapfer C, Glickfeld LL, Atallah BV, Scanziani M
• It's about time for thalamocortical circuits.
  Nature neuroscience 2007 Hull C, Scanziani M
• Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells.
  Nature neuroscience 2006 Glickfeld LL, Scanziani M
• Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition.
  Neuron 2005 Gabernet L, Jadhav SP, Feldman DE, Carandini M, Scanziani M
• Self-administering cannabinoids.
  Trends in neurosciences 2005 Glickfeld LL, Scanziani M
• A precritical period for plasticity in visual cortex.
  Current opinion in neurobiology 2005 Feller MB, Scanziani M
• Routing of spike series by dynamic circuits in the hippocampus.
  Nature 2004 Pouille F, Scanziani M
• Competing on the edge.
  Trends in neurosciences 2002 Scanziani M
• Erratum: Cooperation between independent hippocampal synapses is controlled by glutamate uptake.
  Nature Neuroscience 2002 Nina Arnth-Jensen, Denis Jabaudon, Massimo Scanziani
• Cooperation between independent hippocampal synapses is controlled by glutamate uptake.
  Nature neuroscience 2002 Arnth-Jensen N, Jabaudon D, Scanziani M
• Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition.
  Science (New York, N.Y.) 2001 Pouille F, Scanziani M
• Acute decrease in net glutamate uptake during energy deprivation.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Jabaudon D, Scanziani M, Gähwiler BH, Gerber U
• GABA spillover activates postsynaptic GABA(B) receptors to control rhythmic hippocampal activity.
  Neuron 2000 Scanziani M
• G-protein-independent signaling mediated by metabotropic glutamate receptors.
  Nature neuroscience 1999 Heuss C, Scanziani M, Gähwiler BH, Gerber U
• Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Jabaudon D, Shimamoto K, Yasuda-Kamatani Y, Scanziani M, Gähwiler BH, Gerber U
• Target cell-specific modulation of transmitter release at terminals from a single axon.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Scanziani M, Gähwiler BH, Charpak S
• Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission.
  Journal of neurochemistry 1998 Hampson AJ, Bornheim LM, Scanziani M, Yost CS, Gray AT, Hansen BM, Leonoudakis DJ, Bickler PE
• Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors.
  Nature 1997 Scanziani M, Salin PA, Vogt KE, Malenka RC, Nicoll RA
• Distinct short-term plasticity at two excitatory synapses in the hippocampus.
  Proceedings of the National Academy of Sciences of the United States of America 1996 Salin PA, Scanziani M, Malenka RC, Nicoll RA
• Functional characterization and modulation of feedback inhibitory circuits in area CA3 of rat hippocampal slice cultures.
  The European journal of neuroscience 1996 Fortunato C, Debanne D, Scanziani M, Gähwiler BH, Thompson SM
• Role of intercellular interactions in heterosynaptic long-term depression.
  Nature 1996 Scanziani M, Malenka RC, Nicoll RA
• Functional characterization and modulation of feedback inhibitory circuits in area CA3 of hippocampal slice cultures.
  Journal of Physiology-Paris 1996 C Fortunato, D Debanne, M Scanziani, B.H. Gähwiler, SM Thompson
• Heterosynaptic long-term depression in the hippocampus.
  Journal of physiology, Paris 1996 Scanziani M, Nicoll RA, Malenka RC
• Presynaptic inhibition of excitatory synaptic transmission by muscarinic and metabotropic glutamate receptor activation in the hippocampus: are Ca2+ channels involved?
  Neuropharmacology 1995 Scanziani M, Gahwiler BH, Thompson SM
• Role of excitatory amino acid and GABAB receptors in the generation of epileptiform activity in disinhibited hippocampal slice cultures.
  Neuroscience 1994 Scanziani M, Debanne D, Müller M, Gähwiler BH, Thompson SM
• Presynaptic inhibition of excitatory synaptic transmission mediated by alpha adrenergic receptors in area CA3 of the rat hippocampus in vitro.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1993 Scanziani M, Gähwiler BH, Thompson SM
• Reply.
  Trends in Neurosciences 1993 Scott M. Thompson, Mario Capogna, Massimo Scanziani
• Presynaptic inhibition in the hippocampus.
  Trends in neurosciences 1993 Thompson SM, Capogna M, Scanziani M
• Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus.
  Neuron 1992 Scanziani M, Capogna M, Gähwiler BH, Thompson SM
• Paroxysmal inhibitory potentials mediated by GABAB receptors in partially disinhibited rat hippocampal slice cultures.
  The Journal of physiology 1991 Scanziani M, Gähwiler BH, Thompson SM