Mary Kate Hayward, PhD
Specialist
Surgery
School of Medicine

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California San Francisco 10/2021
• PhD Tumor Biology Barts Cancer Institute 12/2018
• MSc Cancer Therapeutics Queen Mary University of London 06/2014
• BSc Biochemistry University of Kent 06/2013

Publications (10)

Top publication keywords:
Tumor MicroenvironmentBreast NeoplasmsInflammationMacrophagesCollagenMammary Glands, HumanDNA DamageLipid PeroxidationCancer-Associated FibroblastsTrans-ActivatorsOncogene ProteinsCarcinoma, Pancreatic DuctalReactive Oxygen SpeciesCD8-Positive T-LymphocytesFibrosis

• Single molecule Grb2 dynamics reveal spatiomechanical modulation of RTK signaling across length scales.
  bioRxiv : the preprint server for biology 2026 Jain K, Thakar D, Parihar K, Lin JJ, Hayward MK, Musiime M, Lakins J, Hansen SD, Radhakrishnan R, Groves JT, Weaver VM, Low-Nam ST
• Tissue tension fosters macrophage-driven lipid peroxidation-induced DNA damage.
  Cancer cell 2026 Hayward MK, Northey JJ, Opazo-Mellado V, Stashko C, Maller O, Ironside AJ, Que X, Lakins JN, Hwang ES, Witztum JL, Gonzalez H, Weaver VM
• Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling.
  bioRxiv : the preprint server for biology 2025 Nakagawa R, Beardsley A, Durney S, Hayward MK, Subramanyam V, Meyer NP, Wismer H, Goodarzi H, Weaver VM, Van de Mark D, Goga A
• Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment.
  Nature cancer 2024 Tharp KM, Kersten K, Maller O, Timblin GA, Stashko C, Canale FP, Menjivar RE, Hayward MK, Berestjuk I, Ten Hoeve J, Samad B, Ironside AJ, di Magliano MP, Muir A, Geiger R, Combes AJ, Weaver VM
• Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk.
  Cell stem cell 2024 Northey JJ, Hayward MK, Yui Y, Stashko C, Kai F, Mouw JK, Thakar D, Lakins JN, Ironside AJ, Samson S, Mukhtar RA, Hwang ES, Weaver VM

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• A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer.
  Nature communications 2023 Stashko C, Hayward MK, Northey JJ, Pearson N, Ironside AJ, Lakins JN, Oria R, Goyette MA, Mayo L, Russnes HG, Hwang ES, Kutys ML, Polyak K, Weaver VM
• Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion.
  NPJ breast cancer 2022 Hayward MK, Allen MD, Gomm JJ, Goulding I, Thompson CL, Knight MM, Marshall JF, Jones JL
• Derivation of a nuclear heterogeneity image index to grade DCIS
  Computational and Structural Biotechnology Journal 2020 Mary-Kate Hayward, J. Louise Jones, Allison Hall, Lorraine King, Alastair J. Ironside, Andrew C. Nelson, E. Shelley Hwang, Valerie M. Weaver
• Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.
  The Journal of clinical investigation 2020 Northey JJ, Barrett AS, Acerbi I, Hayward MK, Talamantes S, Dean IS, Mouw JK, Ponik SM, Lakins JN, Huang PJ, Wu J, Shi Q, Samson S, Keely PJ, Mukhtar RA, Liphardt JT, Shepherd JA, Hwang ES, Chen YY, …
• Fibrosis and cancer: A strained relationship.
  Biochimica et biophysica acta. Reviews on cancer 2020 Piersma B, Hayward MK, Weaver VM