Mary Kate Hayward, PhD
Specialist
Surgery
School of Medicine

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California San Francisco 10/2021
• PhD Tumor Biology Barts Cancer Institute 12/2018
• MSc Cancer Therapeutics Queen Mary University of London 06/2014
• BSc Biochemistry University of Kent 06/2013

Publications (11)

Top publication keywords:
Breast NeoplasmsCarcinoma, Intraductal, NoninfiltratingMechanotransduction, CellularOrgan SpecificityArtificial IntelligenceCollagenMammary Glands, HumanNeoplastic Stem CellsCell AdhesionOncogenesImage Interpretation, Computer-AssistedMicroscopyCancer-Associated FibroblastsDiagnosis, Computer-AssistedOncogene Proteins

• Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling.
  bioRxiv : the preprint server for biology 2024 Nakagawa R, Beardsley A, Durney S, Hayward MK, Subramanyam V, Meyer NP, Wismer H, Goodarzi H, Weaver VM, Van de Mark D, Goga A
• Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment.
  Nature cancer 2024 Tharp KM, Kersten K, Maller O, Timblin GA, Stashko C, Canale FP, Menjivar RE, Hayward MK, Berestjuk I, Ten Hoeve J, Samad B, Ironside AJ, di Magliano MP, Muir A, Geiger R, Combes AJ, Weaver VM
• Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk.
  Cell stem cell 2024 Northey JJ, Hayward MK, Yui Y, Stashko C, Kai F, Mouw JK, Thakar D, Lakins JN, Ironside AJ, Samson S, Mukhtar RA, Hwang ES, Weaver VM
• A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer.
  Nature communications 2023 Stashko C, Hayward MK, Northey JJ, Pearson N, Ironside AJ, Lakins JN, Oria R, Goyette MA, Mayo L, Russnes HG, Hwang ES, Kutys ML, Polyak K, Weaver VM
• Immunosuppressive glycoproteins associate with breast tumor fibrosis and aggression.
  Matrix biology plus 2022 Metcalf KJ, Hayward MK, Berens E, Ironside AJ, Stashko C, Hwang ES, Weaver VM

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• Tissue mechanics in stem cell fate, development, and cancer.
  Developmental cell 2021 Hayward MK, Muncie JM, Weaver VM
• Improving DCIS diagnosis and predictive outcome by applying artificial intelligence.
  Biochimica et biophysica acta. Reviews on cancer 2021 Hayward MK, Weaver VM
• Derivation of a nuclear heterogeneity image index to grade DCIS
  Computational and Structural Biotechnology Journal 2020 Mary-Kate Hayward, J. Louise Jones, Allison Hall, Lorraine King, Alastair J. Ironside, Andrew C. Nelson, E. Shelley Hwang, Valerie M. Weaver
• Derivation of a nuclear heterogeneity image index to grade DCIS.
  Computational and structural biotechnology journal 2020 Hayward MK, Louise Jones J, Hall A, King L, Ironside AJ, Nelson AC, Shelley Hwang E, Weaver VM
• Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.
  The Journal of clinical investigation 2020 Northey JJ, Barrett AS, Acerbi I, Hayward MK, Talamantes S, Dean IS, Mouw JK, Ponik SM, Lakins JN, Huang PJ, Wu J, Shi Q, Samson S, Keely PJ, Mukhtar RA, Liphardt JT, Shepherd JA, Hwang ES, Chen YY, …
• Fibrosis and cancer: A strained relationship.
  Biochimica et biophysica acta. Reviews on cancer 2020 Piersma B, Hayward MK, Weaver VM