Mary Helen Barcellos-Hoff, PhD
Professor
Radiation Oncology
School of Medicine

Translational research based on aspects of these low dose radiation studies provided new insights into the role of transforming growth factor beta (TGFß) in genomic stability and the DNA damage response and a rationale for implementing TGFß inhibition during radiotherapy. Her research shows that radiation-induced activation of TGFß mediates cancer cell response to genotoxic therapy, affects malignant cell phenotypes, alters the composition of the tumor microenvironment, and inhibits immunological responses that could eliminate cancer. Detailed understanding of how TGFß opposes effective cancer therapy are necessary for identifying patients who could benefit from TGFß inhibitors.

Dr. Barcellos-Hoff received an undergraduate degree from the University of Chicago and earned a doctoral degree in experimental pathology from the University of California, San Francisco. She conducted postdoctoral research on extracellular matrix mediated functional differentiation with Mina Bissell at the Lawrence Berkeley National Laboratory (LBNL). She joined LBNL as a staff scientist, where she rose from postdoctoral fellow to Senior Scientist and Associate Director of the Life Sciences Division. She joined New York University School of Medicine in 2008 as Director of Radiation Biology in the Department of Radiation Oncology. In 2015, he moved to UCSF as Professor and Vice Chair of Research in the Department of Radiation Oncology.

• Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer.
  Cell 2023 Chowdhury S, Kennedy JJ, Ivey RG, Murillo OD, Hosseini N, Song X, Petralia F, Calinawan A, Savage SR, Berry AB, Reva B, Ozbek U, Krek A, Ma W, da Veiga Leprevost F, Ji J, Yoo S, Lin C, Voytovich UJ, …
• Updates on radiotherapy-immunotherapy combinations: Proceedings of 6th annual ImmunoRad conference.
  Oncoimmunology 2023 Gregucci F, Spada S, Barcellos-Hoff MH, Bhardwaj N, Chan Wah Hak C, Fiorentino A, Guha C, Guzman ML, Harrington K, Herrera FG, Honeychurch J, Hong T, Iturri L, Jaffee E, Karam SD, Knott SRV, Koumenis …
• Monitoring TGFβ signaling in irradiated tumors.
  Methods in cell biology 2023 Ma L, Gonzalez-Junca A, Chou W, Barcellos-Hoff MH
• Molecular Pathways and Mechanisms of TGFβ in Cancer Therapy.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Barcellos-Hoff MH, Gulley JL
• Validation of Anticorrelated TGFβ Signaling and Alternative End-Joining DNA Repair Signatures that Predict Response to Genotoxic Cancer Therapy.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2022 Guix I, Liu Q, Pujana MA, Ha P, Piulats J, Linares I, Guedea F, Mao JH, Lazar A, Chapman J, Yom SS, Ashworth A, Barcellos-Hoff MH
• SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal.
  Developmental cell 2022 Yu T, Cazares O, Tang AD, Kim HY, Wald T, Verma A, Liu Q, Barcellos-Hoff MH, Floor SN, Jung HS, Brooks AN, Klein OD
• From Mouse to Human: Cellular Morphometric Subtype Learned From Mouse Mammary Tumors Provides Prognostic Value in Human Breast Cancer.
  Frontiers in oncology 2022 Chang H, Yang X, Moore J, Liu XP, Jen KY, Snijders AM, Ma L, Chou W, Corchado-Cobos R, García-Sancha N, Mendiburu-Eliçabe M, Pérez-Losada J, Barcellos-Hoff MH, Mao JH
• The radiobiology of TGFβ.
  Seminars in cancer biology 2022 Barcellos-Hoff MH
• Dual inhibition of TGF-β and PD-L1: a novel approach to cancer treatment.
  Molecular oncology 2022 Gulley JL, Schlom J, Barcellos-Hoff MH, Wang XJ, Seoane J, Audhuy F, Lan Y, Dussault I, Moustakas A
• Mammary Tumor-Derived Transplants as Breast Cancer Models to Evaluate Tumor-Immune Interactions and Therapeutic Responses.
  Cancer research 2021 Moore J, Ma L, Lazar AA, Barcellos-Hoff MH
• Exploiting Canonical TGFβ Signaling in Cancer Treatment.
  Molecular cancer therapeutics 2021 Liu Q, Chen G, Moore J, Guix I, Placantonakis D, Barcellos-Hoff MH
• Altered regulation of BRCA1 exon 11 splicing is associated with breast cancer risk in carriers of BRCA1 pathogenic variants.
  Human mutation 2021 Ruiz de Garibay G, Fernandez-Garcia I, Mazoyer S, Leme de Calais F, Ameri P, Vijayakumar S, Martinez-Ruiz H, Damiola F, Barjhoux L, Thomassen M, Andersen LVB, Herranz C, Mateo F, Palomero L, Espín R, …
• Editorial: Cell Signaling Mediating Critical Radiation Responses.
  Frontiers in oncology 2021 Herskind C, Barcellos-Hoff MH
• Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types.
  Science translational medicine 2021 Liu Q, Palomero L, Moore J, Guix I, Espín R, Aytés A, Mao JH, Paulovich AG, Whiteaker JR, Ivey RG, Iliakis G, Luo D, Chalmers AJ, Murnane J, Pujana MA, Barcellos-Hoff MH
• Inflammation Mediates the Development of Aggressive Breast Cancer Following Radiotherapy.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Ma L, Gonzalez-Junca A, Zheng Y, Ouyang H, Illa-Bochaca I, Horst KC, Krings G, Wang Y, Fernandez-Garcia I, Chou W, Barcellos-Hoff MH
• In Memoriam - Zena Werb 1945-2020.
  Journal of mammary gland biology and neoplasia 2020 Barcellos-Hoff MH, Weaver VM
• Positron Emission Tomography Imaging of Functional Transforming Growth Factor β (TGFβ) Activity and Benefit of TGFβ Inhibition in Irradiated Intracranial Tumors.
  International journal of radiation oncology, biology, physics 2020 Gonzalez-Junca A, Reiners O, Borrero-Garcia LD, Beckford-Vera D, Lazar AA, Chou W, Braunstein S, VanBrocklin H, Franc BL, Barcellos-Hoff MH
• Aggressive Mammary Cancers Lacking Lymphocytic Infiltration Arise in Irradiated Mice and Can Be Prevented by Dietary Intervention.
  Cancer immunology research 2019 Omene C, Ma L, Moore J, Ouyang H, Illa-Bochaca I, Chou W, Patel MS, Sebastiano C, Demaria S, Mao JH, Karagoz K, Gatza ML, Barcellos-Hoff MH
• Misrepair in Context: TGFβ Regulation of DNA Repair.
  Frontiers in oncology 2019 Liu Q, Lopez K, Murnane J, Humphrey T, Barcellos-Hoff MH
• Enhancing Career Paths for Tomorrow's Radiation Oncologists.
  International journal of radiation oncology, biology, physics 2019 Vapiwala N, Thomas CR, Grover S, Yap ML, Mitin T, Shulman LN, Gospodarowicz MK, Longo J, Petereit DG, Ennis RD, Hayman JA, Rodin D, Buchsbaum JC, Vikram B, Abdel-Wahab M, Epstein AH, Okunieff P, …
• Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment.
  Cancer immunology research 2018 Gonzalez-Junca A, Driscoll KE, Pellicciotta I, Du S, Lo CH, Roy R, Parry R, Tenvooren I, Marquez DM, Spitzer MH, Barcellos-Hoff MH
• Subjugation of TGFβ Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End Joining.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Liu Q, Ma L, Jones T, Palomero L, Pujana MA, Martinez-Ruiz H, Ha PK, Murnane J, Cuartas I, Seoane J, Baumann M, Linge A, Barcellos-Hoff MH
• Evaluation of Radioresponse and Radiosensitizers in Glioblastoma Organotypic Cultures.
  Methods in molecular biology (Clifton, N.J.) 2018 Bayin NS, Ma L, Placantonakis DG, Barcellos-Hoff MH
• Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells.
  Oncotarget 2017 Bayin NS, Frenster JD, Sen R, Si S, Modrek AS, Galifianakis N, Dolgalev I, Ortenzi V, Illa-Bochaca I, Khahera A, Serrano J, Chiriboga L, Zagzag D, Golfinos JG, Doyle W, Tsirigos A, Heguy A, Chesler M,…
• Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate. Report of an NCI Workshop, September 19, 2016.
  Radiation research 2017 Citrin DE, Prasanna PGS, Walker AJ, Freeman ML, Eke I, Barcellos-Hoff MH, Arankalayil MJ, Cohen EP, Wilkins RC, Ahmed MM, Anscher MS, Movsas B, Buchsbaum JC, Mendonca MS, Wynn TA, Coleman CN
• Hydrogen Peroxide Enhances TGFβ-mediated Epithelial-to-Mesenchymal Transition in Human Mammary Epithelial MCF-10A Cells.
  Anticancer research 2017 Iizuka D, Sasatani M, Barcellos-Hoff MH, Kamiya K
• Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.
  Oncogene 2016 Mateo F, Arenas EJ, Aguilar H, Serra-Musach J, de Garibay GR, Boni J, Maicas M, Du S, Iorio F, Herranz-Ors C, Islam A, Prado X, Llorente A, Petit A, Vidal A, Català I, Soler T, Venturas G, Rojo-…
• A TGFβ-miR-182-BRCA1 axis controls the mammary differentiation hierarchy.
  Science signaling 2016 Martinez-Ruiz H, Illa-Bochaca I, Omene C, Hanniford D, Liu Q, Hernando E, Barcellos-Hoff MH
• Patient-Specific Screening Using High-Grade Glioma Explants to Determine Potential Radiosensitization by a TGF-β Small Molecule Inhibitor.
  Neoplasia (New York, N.Y.) 2016 Bayin NS, Ma L, Thomas C, Baitalmal R, Sure A, Fansiwala K, Bustoros M, Golfinos JG, Pacione D, Snuderl M, Zagzag D, Barcellos-Hoff MH, Placantonakis D
• Subverting misconceptions about radiation therapy.
  Nature immunology 2016 Formenti SC, Demaria S, Barcellos-Hoff MH, McBride WH
• HZE Radiation Non-Targeted Effects on the Microenvironment That Mediate Mammary Carcinogenesis.
  Frontiers in oncology 2016 Barcellos-Hoff MH, Mao JH
• ICRP Publication 131: Stem cell biology with respect to carcinogenesis aspects of radiological protection.
  Annals of the ICRP 2016 Hendry JH, Niwa O, Barcellos-Hoff MH, Globus RK, Harrison JD, Martin MT, Seed TM, Shay JW, Story MD, Suzuki K, Yamashita S
• The Microenvironment of Lung Cancer and Therapeutic Implications.
  Advances in experimental medicine and biology 2016 Mittal V, El Rayes T, Narula N, McGraw TE, Altorki NK, Barcellos-Hoff MH
• "Praising What Is Lost. . .
  Radiation research 2015 Barcellos-Hoff MH, Iliakis G, Jeggo P, McKenna G, O'Neil P, Wallace S
• ICRP Publication 131: Stem Cell Biology with Respect to Carcinogenesis Aspects of Radiological Protection.
  Annals of the ICRP 2015 Niwa O, Barcellos-Hoff MH, Globus RK, Harrison JD, Hendry JH, Jacob P, Martin MT, Seed TM, Shay JW, Story MD, Suzuki K, Yamashita S, ICRP
• Whither ICRR?
  Radiation research 2015 Brown M, Held K, Mason K, McBride B, Willey J, Williams J
• TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair.
  Oncogene 2015 Qiang L, Shah P, Barcellos-Hoff MH, He YY
• Concepts and challenges in cancer risk prediction for the space radiation environment.
  Life sciences in space research 2015 Barcellos-Hoff MH, Blakely EA, Burma S, Fornace AJ, Gerson S, Hlatky L, Kirsch DG, Luderer U, Shay J, Wang Y, Weil MM
• The effect of environmental chemicals on the tumor microenvironment.
  Carcinogenesis 2015 Casey SC, Vaccari M, Al-Mulla F, Al-Temaimi R, Amedei A, Barcellos-Hoff MH, Brown DG, Chapellier M, Christopher J, Curran CS, Forte S, Hamid RA, Heneberg P, Koch DC, Krishnakumar PK, Laconi E, Maguer-…
• Eukaryotic Translation Initiation Factor 4E Is a Feed-Forward Translational Coactivator of Transforming Growth Factor β Early Protransforming Events in Breast Epithelial Cells.
  Molecular and cellular biology 2015 Decarlo L, Mestel C, Barcellos-Hoff MH, Schneider RJ
• TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity.
  Cancer research 2015 Vanpouille-Box C, Diamond JM, Pilones KA, Zavadil J, Babb JS, Formenti SC, Barcellos-Hoff MH, Demaria S
• Identification of genetic loci that control mammary tumor susceptibility through the host microenvironment.
  Scientific reports 2015 Zhang P, Lo A, Huang Y, Huang G, Liang G, Mott J, Karpen GH, Blakely EA, Bissell MJ, Barcellos-Hoff MH, Snijders AM, Mao JH
• BUB1-bling over with possibilities.
  Neoplasia (New York, N.Y.) 2015 Barcellos-Hoff MH
• Age- and pregnancy-associated DNA methylation changes in mammary epithelial cells.
  Stem cell reports 2015 Huh SJ, Clement K, Jee D, Merlini A, Choudhury S, Maruyama R, Yoo R, Chytil A, Boyle P, Ran FA, Moses HL, Barcellos-Hoff MH, Jackson-Grusby L, Meissner A, Polyak K
• Development of a novel multiplexed assay for quantification of transforming growth factor-β (TGF-β).
  Growth factors (Chur, Switzerland) 2015 Pellicciotta I, Marciscano AE, Hardee ME, Francis D, Formenti S, Barcellos-Hoff MH
• Attenuation of the DNA damage response by transforming growth factor-beta inhibitors enhances radiation sensitivity of non-small-cell lung cancer cells in vitro and in vivo.
  International journal of radiation oncology, biology, physics 2015 Du S, Bouquet S, Lo CH, Pellicciotta I, Bolourchi S, Parry R, Barcellos-Hoff MH
• TGFβ1 protects cells from γ-IR by enhancing the activity of the NHEJ repair pathway.
  Molecular cancer research : MCR 2014 Kim MR, Lee J, An YS, Jin YB, Park IC, Chung E, Shin I, Barcellos-Hoff MH, Yi JY
• Densely ionizing radiation acts via the microenvironment to promote aggressive Trp53-null mammary carcinomas.
  Cancer research 2014 Illa-Bochaca I, Ouyang H, Tang J, Sebastiano C, Mao JH, Costes SV, Demaria S, Barcellos-Hoff MH
• Distinct luminal-type mammary carcinomas arise from orthotopic Trp53-null mammary transplantation of juvenile versus adult mice.
  Cancer research 2014 Nguyen DH, Ouyang H, Mao JH, Hlatky L, Barcellos-Hoff MH
• New tricks for an old fox: impact of TGFβ on the DNA damage response and genomic stability.
  Science signaling 2014 Barcellos-Hoff MH, Cucinotta FA
• Soil amendments that slow cancer growth.
  Cancer discovery 2014 Isacke CM, Barcellos-Hoff MH
• Photoactivation of endogenous latent transforming growth factor-β1 directs dental stem cell differentiation for regeneration.
  Science translational medicine 2014 Arany PR, Cho A, Hunt TD, Sidhu G, Shin K, Hahm E, Huang GX, Weaver J, Chen AC, Padwa BL, Hamblin MR, Barcellos-Hoff MH, Kulkarni AB, J Mooney D
• Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors.
  Stem cells (Dayton, Ohio) 2014 Tang J, Fernandez-Garcia I, Vijayakumar S, Martinez-Ruis H, Illa-Bochaca I, Nguyen DH, Mao JH, Costes SV, Barcellos-Hoff MH
• Noninvasive diagnosis and management of spontaneous intracranial hypotension in patients with marfan syndrome: Case Report and Review of the Literature.
  Surgical neurology international 2014 Bassani L, Graffeo CS, Behrooz N, Tyagi V, Wilson T, Penaranda S, Zagzag D, Rifkin DB, Barcellos-Hoff MH, Fatterpekar G, Placantonakis D
• Breast cancer risk in BRCA1 mutation carriers: insight from mouse models.
  Annals of oncology : official journal of the European Society for Medical Oncology 2013 Barcellos-Hoff MH, Kleinberg DL
• Tumors as organs: biologically augmenting radiation therapy by inhibiting transforming growth factor β activity in carcinomas.
  Seminars in radiation oncology 2013 Du S, Barcellos-Hoff MH
• The evolution of the cancer niche during multistage carcinogenesis.
  Nature reviews. Cancer 2013 Barcellos-Hoff MH, Lyden D, Wang TC
• Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Nguyen DH, Fredlund E, Zhao W, Perou CM, Balmain A, Mao JH, Barcellos-Hoff MH
• New biological insights on the link between radiation exposure and breast cancer risk.
  Journal of mammary gland biology and neoplasia 2013 Barcellos-Hoff MH
• Does microenvironment contribute to the etiology of estrogen receptor-negative breast cancer?
  Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Barcellos-Hoff MH
• The convergence of radiation and immunogenic cell death signaling pathways.
  Frontiers in oncology 2012 Golden EB, Pellicciotta I, Demaria S, Barcellos-Hoff MH, Formenti SC
• Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.
  Cancer research 2012 Hardee ME, Marciscano AE, Medina-Ramirez CM, Zagzag D, Narayana A, Lonning SM, Barcellos-Hoff MH
• Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.
  PLoS biology 2011 Maxwell CA, Benítez J, Gómez-Baldó L, Osorio A, Bonifaci N, Fernández-Ramires R, Costes SV, Guinó E, Chen H, Evans GJ, Mohan P, Català I, Petit A, Aguilar H, Villanueva A, Aytes A, Serra-Musach J, …
• TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Bouquet F, Pal A, Pilones KA, Demaria S, Hann B, Akhurst RJ, Babb JS, Lonning SM, DeWyngaert JK, Formenti SC, Barcellos-Hoff MH
• The pivotal role of insulin-like growth factor I in normal mammary development.
  Endocrinology and metabolism clinics of North America 2011 Kleinberg DL, Barcellos-Hoff MH
• TGFβ biology in breast: 15 years on.
  Journal of mammary gland biology and neoplasia 2011 Barcellos-Hoff MH
• Consequences of epithelial or stromal TGFβ1 depletion in the mammary gland.
  Journal of mammary gland biology and neoplasia 2011 Nguyen DH, Martinez-Ruiz H, Barcellos-Hoff MH
• Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type.
  Cancer cell 2011 Nguyen DH, Oketch-Rabah HA, Illa-Bochaca I, Geyer FC, Reis-Filho JS, Mao JH, Ravani SA, Zavadil J, Borowsky AD, Jerry DJ, Dunphy KA, Seo JH, Haslam S, Medina D, Barcellos-Hoff MH
• Low-dose radiation knowledge worth the cost.
  Science (New York, N.Y.) 2011 Barcellos-Hoff MH, Brenner DJ, Brooks AL, Formenti S, Hlatky L, Locke PA, Shore R, Tenforde T, Travis EL, Williams J
• Lack of radiation dose or quality dependence of epithelial-to-mesenchymal transition (EMT) mediated by transforming growth factor β.
  International journal of radiation oncology, biology, physics 2011 Andarawewa KL, Costes SV, Fernandez-Garcia I, Chou WS, Ravani SA, Park H, Barcellos-Hoff MH
• In honor of Mina J. Bissell.
  Integrative biology : quantitative biosciences from nano to macro 2011 Barcellos-Hoff MH
• What is the use of systems biology approaches in radiation biology?
  Health physics 2011 Barcellos-Hoff MH
• TGF-beta biology in mammary development and breast cancer.
  Cold Spring Harbor perspectives in biology 2011 Moses H, Barcellos-Hoff MH
• Stromal mediation of radiation carcinogenesis.
  Journal of mammary gland biology and neoplasia 2010 Barcellos-Hoff MH
• Multiscale iterative voting for differential analysis of stress response for 2D and 3D cell culture models.
  Journal of microscopy 2010 Han J, Chang H, Yang Q, Fontenay G, Groesser T, Barcellos-Hoff MH, Parvin B
• Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies.
  Breast cancer research : BCR 2010 Mukhopadhyay R, Costes SV, Bazarov AV, Hines WC, Barcellos-Hoff MH, Yaswen P
• Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization.
  Mutation research 2010 Costes SV, Chiolo I, Pluth JM, Barcellos-Hoff MH, Jakob B
• In situ analysis of cell populations: long-term label-retaining cells.
  Methods in molecular biology (Clifton, N.J.) 2010 Fernandez-Gonzalez R, Illa-Bochaca I, Shelton DN, Welm BE, Barcellos-Hoff MH, Ortiz-de-Solorzano C
• Limiting-dilution transplantation assays in mammary stem cell studies.
  Methods in molecular biology (Clifton, N.J.) 2010 Illa-Bochaca I, Fernandez-Gonzalez R, Shelton DN, Welm BE, Ortiz-de-Solorzano C, Barcellos-Hoff MH
• Multidimensional profiling of cell surface proteins and nuclear markers.
  IEEE/ACM transactions on computational biology and bioinformatics 2010 Han J, Chang H, Andarawewa K, Yaswen P, Barcellos-Hoff MH, Parvin B
• Use of stem cell markers in dissociated mammary populations.
  Methods in molecular biology (Clifton, N.J.) 2010 Shelton DN, Fernandez-Gonzalez R, Illa-Bochaca I, Ortiz-de-Solorzano C, Barcellos-Hoff MH, Welm BE
• Radiation carcinogenesis in context: how do irradiated tissues become tumors?
  Health physics 2009 Barcellos-Hoff MH, Nguyen DH
• Resistance to radio- and chemotherapy and the tumour microenvironment.
  International journal of radiation biology 2009 Barcellos-Hoff MH, Cordes N
• Therapeutic targets in malignant glioblastoma microenvironment.
  Seminars in radiation oncology 2009 Barcellos-Hoff MH, Newcomb EW, Zagzag D, Narayana A
• Transforming growth factor-beta in breast cancer: too much, too late.
  Breast cancer research : BCR 2009 Barcellos-Hoff MH, Akhurst RJ
• The development of integrative biology: bridging the gap--a view from the Scientific Editors. [An interview with David Beebe and Mary Helen Barcellos-Hoff by Kathleen Too].
  Integrative biology : quantitative biosciences from nano to macro 2009 Beebe D, Barcellos-Hoff MH
• Integrating biology and technology.
  Integrative biology : quantitative biosciences from nano to macro 2009 Barcellos-Hoff MH, Beebe D
• Estrogen and progesterone receptors have distinct roles in the establishment of the hyperplastic phenotype in PR-A transgenic mice.
  Breast cancer research : BCR 2009 Simian M, Bissell MJ, Barcellos-Hoff MH, Shyamala G
• Mapping mammary gland architecture using multi-scale in situ analysis.
  Integrative biology : quantitative biosciences from nano to macro 2008 Fernandez-Gonzalez R, Illa-Bochaca I, Welm BE, Fleisch MC, Werb Z, Ortiz-de-Solorzano C, Barcellos-Hoff MH
• Targeted and nontargeted effects of ionizing radiation that impact genomic instability.
  Cancer research 2008 Maxwell CA, Fleisch MC, Costes SV, Erickson AC, Boissière A, Gupta R, Ravani SA, Parvin B, Barcellos-Hoff MH
• Karyotypic instability and centrosome aberrations in the progeny of finite life-span human mammary epithelial cells exposed to sparsely or densely ionizing radiation.
  Radiation research 2008 Sudo H, Garbe J, Stampfer MR, Barcellos-Hoff MH, Kronenberg A
• Cancer as an emergent phenomenon in systems radiation biology.
  Radiation and environmental biophysics 2007 Barcellos-Hoff MH
• New rationales for using TGFbeta inhibitors in radiotherapy.
  International journal of radiation biology 2007 Andarawewa KL, Paupert J, Pal A, Barcellos-Hoff MH
• Radiation therapy and the microenvironment.
  International journal of radiation biology 2007 Barcellos-Hoff MH, Cordes N
• Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition.
  Cancer research 2007 Andarawewa KL, Erickson AC, Chou WS, Costes SV, Gascard P, Mott JD, Bissell MJ, Barcellos-Hoff MH
• Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains.
  PLoS computational biology 2007 Costes SV, Ponomarev A, Chen JL, Nguyen D, Cucinotta FA, Barcellos-Hoff MH
• The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.
  Molecular oncology 2007 Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT, Lorenz K, Lee EH, Barcellos-Hoff MH, Petersen OW, Gray JW, Bissell MJ
• Iterative voting for inference of structural saliency and characterization of subcellular events.
  IEEE transactions on image processing : a publication of the IEEE Signal Processing Society 2007 Parvin B, Yang Q, Han J, Chang H, Rydberg B, Barcellos-Hoff MH
• Geometric approach to segmentation and protein localization in cell culture assays.
  Journal of microscopy 2007 Raman S, Maxwell CA, Barcellos-Hoff MH, Parvin B
• Intensity-based signal separation algorithm for accurate quantification of clustered centrosomes in tissue sections.
  Microscopy research and technique 2006 Fleisch MC, Maxwell CA, Kuper CK, Brown ET, Barcellos-Hoff MH, Costes SV
• Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species.
  Radiation research 2006 Jobling MF, Mott JD, Finnegan MT, Jurukovski V, Erickson AC, Walian PJ, Taylor SE, Ledbetter S, Lawrence CM, Rifkin DB, Barcellos-Hoff MH
• Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress.
  Cancer research 2006 Kirshner J, Jobling MF, Pajares MJ, Ravani SA, Glick AB, Lavin MJ, Koslov S, Shiloh Y, Barcellos-Hoff MH
• Quantitative in vivo microscopy: the return from the 'omics'.
  Current opinion in biotechnology 2006 Fernández-González R, Muñoz-Barrutia A, Barcellos-Hoff MH, Ortiz-de-Solorzano C
• The pleiotropic roles of transforming growth factor beta in homeostasis and carcinogenesis of endocrine organs.
  Endocrine-related cancer 2006 Fleisch MC, Maxwell CA, Barcellos-Hoff MH
• Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts.
  Radiation research 2006 Costes SV, Boissière A, Ravani S, Romano R, Parvin B, Barcellos-Hoff MH
• A systems biology approach to multicellular and multi-generational radiation responses.
  Mutation research 2006 Barcellos-Hoff MH, Costes SV
• Radiation and the microenvironment - tumorigenesis and therapy.
  Nature reviews. Cancer 2005 Barcellos-Hoff MH, Park C, Wright EG
• Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression.
  Oncogene 2005 Muraoka-Cook RS, Shin I, Yi JY, Easterly E, Barcellos-Hoff MH, Yingling JM, Zent R, Arteaga CL
• A tool for the quantitative spatial analysis of complex cellular systems.
  IEEE transactions on image processing : a publication of the IEEE Signal Processing Society 2005 Fernandez-Gonzalez R, Barcellos-Hoff MH, Ortiz-de-Solórzano C
• Cell cycle defects contribute to a block in hormone-induced mammary gland proliferation in CCAAT/enhancer-binding protein (C/EBPbeta)-null mice.
  The Journal of biological chemistry 2005 Grimm SL, Contreras A, Barcellos-Hoff MH, Rosen JM
• Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice.
  The American journal of pathology 2005 Ewan KB, Oketch-Rabah HA, Ravani SA, Shyamala G, Moses HL, Barcellos-Hoff MH
• Integrative radiation carcinogenesis: interactions between cell and tissue responses to DNA damage.
  Seminars in cancer biology 2004 Barcellos-Hoff MH
• Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors.
  Cancer research 2004 Muraoka-Cook RS, Kurokawa H, Koh Y, Forbes JT, Roebuck LR, Barcellos-Hoff MH, Moody SE, Chodosh LA, Arteaga CL
• Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003.
  Radiation research 2004 Stone HB, Moulder JE, Coleman CN, Ang KK, Anscher MS, Barcellos-Hoff MH, Dynan WS, Fike JR, Grdina DJ, Greenberger JS, Hauer-Jensen M, Hill RP, Kolesnick RN, Macvittie TJ, Marks C, McBride WH, Metting…
• New highlights on stroma-epithelial interactions in breast cancer.
  Breast cancer research : BCR 2004 Barcellos-Hoff MH, Medina D
• Quantitative image analysis in mammary gland biology.
  Journal of mammary gland biology and neoplasia 2004 Fernandez-Gonzalez R, Barcellos-Hoff MH, Ortiz-de-Solórzano C
• Education and training for radiation scientists: radiation research program and American Society of Therapeutic Radiology and Oncology Workshop, Bethesda, Maryland, May 12-14, 2003.
  Radiation research 2003 Coleman CN, Stone HB, Alexander GA, Barcellos-Hoff MH, Bedford JS, Bristow RG, Dynlacht JR, Fuks Z, Gorelic LS, Hill RP, Joiner MC, Liu FF, McBride WH, McKenna WG, Powell SN, Robbins ME, Rockwell S, …
• Ionizing radiation induces heritable disruption of epithelial cell interactions.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Park CC, Henshall-Powell RL, Erickson AC, Talhouk R, Parvin B, Bissell MJ, Barcellos-Hoff MH
• The not-so innocent bystander: the microenvironment as a therapeutic target in cancer.
  Expert opinion on therapeutic targets 2003 Erickson AC, Barcellos-Hoff MH
• BioSig: an imaging bioinformatics system for phenotypic analysis.
  IEEE transactions on systems, man, and cybernetics. Part B, Cybernetics : a publication of the IEEE Systems, Man, and Cybernetics Society 2003 Parvin B, Yang Q, Fontenay G, Barcellos-Hoff MH
• System for combined three-dimensional morphological and molecular analysis of thick tissue specimens.
  Microscopy research and technique 2002 Fernandez-Gonzalez R, Jones A, Garcia-Rodriguez E, Chen PY, Idica A, Lockett SJ, Barcellos-Hoff MH, Ortiz-De-Solorzano C
• Applications of quantitative digital image analysis to breast cancer research.
  Microscopy research and technique 2002 Ortiz De Solórzano C, Costes S, Callahan DE, Parvin B, Barcellos-Hoff MH
• Transforming growth factor-beta1 mediates cellular response to DNA damage in situ.
  Cancer research 2002 Ewan KB, Henshall-Powell RL, Ravani SA, Pajares MJ, Arteaga C, Warters R, Akhurst RJ, Barcellos-Hoff MH
• Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts.
  Journal of the National Cancer Institute 2002 Wang F, Hansen RK, Radisky D, Yoneda T, Barcellos-Hoff MH, Petersen OW, Turley EA, Bissell MJ
• Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation.
  The American journal of pathology 2002 Ewan KB, Shyamala G, Ravani SA, Tang Y, Akhurst R, Wakefield L, Barcellos-Hoff MH
• Radiation quality and tissue-specific microenvironments following exposure to 1 GeV/amu Fe.
  Advances in space research : the official journal of the Committee on Space Research (COSPAR) 2002 Costes S, Barcellos-Hoff MH
• Immunodetection of 3-nitrotyrosine in the liver of zymosan-treated rats with a new monoclonal antibody: comparison to analysis by HPLC.
  Free radical biology & medicine 2001 Girault I, Karu AE, Schaper M, Barcellos-Hoff MH, Hagen T, Vogel DS, Ames BN, Christen S, Shigenaga MK
• Extracellular signaling through the microenvironment: a hypothesis relating carcinogenesis, bystander effects, and genomic instability.
  Radiation research 2001 Barcellos-Hoff MH, Brooks AL
• Epigenetics and breast cancer.
  Journal of mammary gland biology and neoplasia 2001 Asch BB, Barcellos-Hoff MH
• It takes a tissue to make a tumor: epigenetics, cancer and the microenvironment.
  Journal of mammary gland biology and neoplasia 2001 Barcellos-Hoff MH
• Three down and counting: the transformation of human mammary cells from normal to malignant in three steps.
  Trends in molecular medicine 2001 Barcellos-Hoff MH
• Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor (M6P/IGF2R) locus predisposes patients to radiation-induced lung injury.
  International journal of radiation oncology, biology, physics 2001 Kong FM, Anscher MS, Sporn TA, Washington MK, Clough R, Barcellos-Hoff MH, Jirtle RL
• Particle irradiation induces FGF2 expression in normal human lens cells.
  Radiation research 2000 Chang PY, Bjornstad K A, Chang E, McNamara M, Barcellos-Hoff MH, Lin SP, Aragon G, Polansky JR, Lui GM, Blakely EA
• Quantitative image analysis of laminin immunoreactivity in skin basement membrane irradiated with 1 GeV/nucleon iron particles.
  Radiation research 2000 Costes S, Streuli CH, Barcellos-Hoff MH
• The influence of the microenvironment on the malignant phenotype.
  Molecular medicine today 2000 Park CC, Bissell MJ, Barcellos-Hoff MH
• Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.
  Cancer research 2000 Barcellos-Hoff MH, Ravani SA
• Transforming growth factor-beta and breast cancer: Mammary gland development.
  Breast cancer research : BCR 2000 Barcellos-Hoff MH, Ewan KB
• Radiation-induced alterations in rat mesangial cell Tgfb1 and Tgfb3 gene expression are not associated with altered secretion of active Tgfb isoforms.
  Radiation research 1999 O'Malley Y, Zhao W, Barcellos-Hoff MH, Robbins ME
• Modulation of protein expression and activity by radiation: relevance to intracoronary radiation for the prevention of restenosis.
  Cardiovascular radiation medicine 1999 Vodovotz Y, Mitchell JB, Lucia MS, McKinney L, Kollum M, Cottin Y, Chan RC, Barcellos-Hoff MH, Waksman R
• Ionizing radiation accelerates aortic lesion formation in fat-fed mice via SOD-inhibitable processes.
  Arteriosclerosis, thrombosis, and vascular biology 1999 Tribble DL, Barcellos-Hoff MH, Chu BM, Gong EL
• Regulation of transforming growth factor beta1 by nitric oxide.
  Cancer research 1999 Vodovotz Y, Chesler L, Chong H, Kim SJ, Simpson JT, DeGraff W, Cox GW, Roberts AB, Wink DA, Barcellos-Hoff MH
• Immunocytochemical localization of latent transforming growth factor-beta1 activation by stimulated macrophages.
  Journal of cellular physiology 1999 Chong H, Vodovotz Y, Cox GW, Barcellos-Hoff MH
• How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues.
  Radiation research 1998 Barcellos-Hoff MH
• The potential influence of radiation-induced microenvironments in neoplastic progression.
  Journal of mammary gland biology and neoplasia 1998 Barcellos-Hoff MH
• Transgenic mice carrying an imbalance in the native ratio of A to B forms of progesterone receptor exhibit developmental abnormalities in mammary glands.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Shyamala G, Yang X, Silberstein G, Barcellos-Hoff MH, Dale E
• In situ localization of progesterone receptors in normal mouse mammary glands: absence of receptors in the connective and adipose stroma and a heterogeneous distribution in the epithelium.
  The Journal of steroid biochemistry and molecular biology 1997 Shyamala G, Barcellos-Hoff MH, Toft D, Yang X
• Latent transforming growth factor beta1 activation in situ: quantitative and functional evidence after low-dose gamma-irradiation.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997 Ehrhart EJ, Segarini P, Tsang ML, Carroll AG, Barcellos-Hoff MH
• Transforming growth factor-beta in breast cancer: a working hypothesis.
  Breast cancer research and treatment 1997 Reiss M, Barcellos-Hoff MH
• Immunohistochemical localization of transforming growth factor beta and tumor necrosis factor alpha in the lungs of fibrosis-prone and "non-fibrosing" mice during the latent period and early phase after irradiation.
  Radiation research 1997 Franko AJ, Sharplin J, Ghahary A, Barcellos-Hoff MH
• Latency and activation in the control of TGF-beta.
  Journal of mammary gland biology and neoplasia 1996 Barcellos-Hoff MH
• Redox-mediated activation of latent transforming growth factor-beta 1.
  Molecular endocrinology (Baltimore, Md.) 1996 Barcellos-Hoff MH, Dix TA
• Immunohistochemical evidence of rapid extracellular matrix remodeling after iron-particle irradiation of mouse mammary gland.
  Radiation research 1996 Ehrhart EJ, Gillette EL, Barcellos-Hoff MH
• Immunohistochemical detection of active transforming growth factor-beta in situ using engineered tissue.
  The American journal of pathology 1995 Barcellos-Hoff MH, Ehrhart EJ, Kalia M, Jirtle R, Flanders K, Tsang ML
• Transforming growth factor-beta activation in irradiated murine mammary gland.
  The Journal of clinical investigation 1994 Barcellos-Hoff MH, Derynck R, Tsang ML, Weatherbee JA
• Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland.
  Cancer research 1993 Barcellos-Hoff MH
• Production of stable phenotypes from 9L rat brain tumor multicellular spheroids treated with 1,3-bis(2-chloroethyl)-1-nitrosourea.
  International journal of cancer 1992 Barcellos-Hoff MH, Linfoot PA, Marton LJ, Deen DF
• Mammary epithelial reorganization on extracellular matrix is mediated by cell surface galactosyltransferase.
  Experimental cell research 1992 Barcellos-Hoff MH
• Cytodifferentiation of mouse mammary epithelial cells cultured on a reconstituted basement membrane reveals striking similarities to development in vivo.
  Journal of cell science 1991 Aggeler J, Ward J, Blackie LM, Barcellos-Hoff MH, Streuli CH, Bissell MJ
• Differential drug sensitivity conferred by growth status detected in a mixed population of cycling and noncycling cells.
  Cancer research 1990 Barcellos-Hoff MH, Marton LJ, Deen DF
• Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane.
  Development (Cambridge, England) 1989 Barcellos-Hoff MH, Aggeler J, Ram TG, Bissell MJ
• Measurement of sister chromatid exchanges and their relationship to DNA damage, repair and cell killing.
  Pharmacology & therapeutics 1989 Deen DF, Morgan WF, Tofilon PJ, Barcellos-Hoff MH
• Cell-cycle, phase-specific cell killing by carmustine in sensitive and resistant cells.
  NCI monographs : a publication of the National Cancer Institute 1988 Linfoot PA, Barcellos-Hoff MH, Brent TP, Marton LJ, Deen DF
• Transferrin is a major mouse milk protein and is synthesized by mammary epithelial cells.
  In vitro cellular & developmental biology : journal of the Tissue Culture Association 1987 Lee EY, Barcellos-Hoff MH, Chen LH, Parry G, Bissell MJ
• The influence of extracellular matrix on gene expression: is structure the message?
  Journal of cell science. Supplement 1987 Bissell MJ, Barcellos-Hoff MH
• Growth delay in 9L rat brain tumor spheroids after irradiation with single and split doses of X rays.
  Radiation research 1985 Jostes RF, Williams ME, Barcellos-Hoff MH, Hoshino T, Deen DF
• The effect of combination treatment with cis-platinum and low dose rate 125I radiation in a murine brachytherapy model.
  International journal of radiation oncology, biology, physics 1984 da Silva V, Gutin PH, Barcellos-Hoff MH, Bernstein MA, Deen DF, Weaver KA