Marta San Luciano Palenzuela, MD
Professor
Neurology
School of Medicine

She has special interests in caring for patients whose genetic background may increase their risk of Parkinson's disease and dystonia, and in developing biomarkers and measuring outcomes, and in medical and especially surgical therapies in movement disorders.

She received her medical degree from the University of Navarra in Spain and earned a master's degree in clinical research methods from the Albert Einstein College of Medicine. She completed an internship in internal medicine at Metropolitan Hospital Center in New York and a residency in neurology at Boston University Medical Center where she was elected chief resident during her final year. She served as a clinical and research fellow in movement disorders at Beth Israel Deaconess Medical Center in New York.

She is an active member of the American Academy of Neurology, International Parkinson and Movement Disorder Society and the Parkinson Study Group.

Her research interests are broadly in clinical and genetic epidemiology of Parkinson's disease, dystonia and other movement disorders and neurodegenerative illnesses, as well as in outcomes research in neuromodulation surgeries for movement disorders. In particular, some of her current research focuses on identifying predictors of favorable motor outcomes following deep brain stimulation surgery in isolated and acquired dystonia, a disabling movement disorder.

• Nonsteroidal Anti-inflammatory Use and LRRK2 Parkinson's Disease Penetrance.
  Movement disorders : official journal of the Movement Disorder Society 2020 San Luciano M, Tanner CM, Meng C, Marras C, Goldman SM, Lang AE, Tolosa E, Schüle B, Langston JW, Brice A, Corvol JC, Goldwurm S, Klein C, Brockman S, Berg D, Brockmann K, Ferreira JJ, Tazir M, …
• Subthalamic nucleus deep brain stimulation with a multiple independent constant current-controlled device in Parkinson's disease (INTREPID): a multicentre, double-blind, randomised, sham-controlled study.
  The Lancet. Neurology 2020 Vitek JL, Jain R, Chen L, Tröster AI, Schrock LE, House PA, Giroux ML, Hebb AO, Farris SM, Whiting DM, Leichliter TA, Ostrem JL, San Luciano M, Galifianakis N, Verhagen Metman L, Sani S, Karl JA, …
• Phenomenology and Management of Subthalamic Stimulation-Induced Dyskinesia in Patients With Isolated Dystonia.
  Movement disorders clinical practice 2020 Bledsoe IO, Dodenhoff KA, San Luciano M, Volz MM, Starr PA, Markun LC, Ostrem JL
• Washout of chronic therapeutic deep brain stimulation increases cortical phase-amplitude coupling.
  Parkinsonism & related disorders 2019 Rajagopalan SS, Miller AM, de Hemptinne C, San Luciano M, Ostrem JL, Starr PA
• Patient Experience with Rechargeable Implantable Pulse Generator Deep Brain Stimulation for Movement Disorders.
  Stereotactic and functional neurosurgery 2019 Mitchell KT, Volz M, Lee A, San Luciano M, Wang S, Starr PA, Larson P, Galifianakis NB, Ostrem JL
• Pallidal Deep-Brain Stimulation Disrupts Pallidal Beta Oscillations and Coherence with Primary Motor Cortex in Parkinson's Disease.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Wang DD, de Hemptinne C, Miocinovic S, Ostrem JL, Galifianakis NB, San Luciano M, Starr PA
• Before and after the veterans affairs cooperative program 468 study: Deep brain stimulator target selection for treatment of Parkinson's disease.
  Parkinsonism & related disorders 2017 Southwell DG, Rutkowski MJ, San Luciano M, Racine C, Ostrem J, Starr PA, Larson PS
• Sex differences in LRRK2 G2019S and idiopathic Parkinson's Disease.
  Annals of clinical and translational neurology 2017 San Luciano M, Wang C, Ortega RA, Giladi N, Marder K, Bressman S, Saunders-Pullman R, Michael J Fox Foundation LRRK2 Consortium
• Parkinson's disease patient preference and experience with various methods of DBS lead placement.
  Parkinsonism & related disorders 2017 LaHue SC, Ostrem JL, Galifianakis NB, San Luciano M, Ziman N, Wang S, Racine CA, Starr PA, Larson PS, Katz M
• Subthalamic nucleus deep brain stimulation in isolated dystonia: A 3-year follow-up study.
  Neurology 2016 Ostrem JL, San Luciano M, Dodenhoff KA, Ziman N, Markun LC, Racine CA, de Hemptinne C, Volz MM, Heath SL, Starr PA
• Digitized Spiral Drawing: A Possible Biomarker for Early Parkinson's Disease.
  PloS one 2016 San Luciano M, Wang C, Ortega RA, Yu Q, Boschung S, Soto-Valencia J, Bressman SB, Lipton RB, Pullman S, Saunders-Pullman R
• Gamma Oscillations in the Hyperkinetic State Detected with Chronic Human Brain Recordings in Parkinson's Disease.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Swann NC, de Hemptinne C, Miocinovic S, Qasim S, Wang SS, Ziman N, Ostrem JL, San Luciano M, Galifianakis NB, Starr PA
• Subthalamic local field potentials in Parkinson's disease and isolated dystonia: An evaluation of potential biomarkers.
  Neurobiology of disease 2016 Wang DD, de Hemptinne C, Miocinovic S, Qasim SE, Miller AM, Ostrem JL, Galifianakis NB, San Luciano M, Starr PA
• Effective Interventional Magnetic Resonance Image-Guided Laser Ablations in a Parkinson's Disease Patient with Refractory Tremor.
  Movement disorders clinical practice 2015 San Luciano M, Katz M, Ostrem J, Martin A, Starr P, Ziman N, Larson P
• Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson's disease.
  Nature neuroscience 2015 de Hemptinne C, Swann NC, Ostrem JL, Ryapolova-Webb ES, San Luciano M, Galifianakis NB, Starr PA
• Higher frequency of certain cancers in LRRK2 G2019S mutation carriers with Parkinson disease: a pooled analysis.
  JAMA neurology 2015 Agalliu I, San Luciano M, Mirelman A, Giladi N, Waro B, Aasly J, Inzelberg R, Hassin-Baer S, Friedman E, Ruiz-Martinez J, Marti-Masso JF, Orr-Urtreger A, Bressman S, Saunders-Pullman R
• Olfactory identification in LRRK2 G2019S mutation carriers: a relevant marker?
  Annals of clinical and translational neurology 2014 Saunders-Pullman R, Mirelman A, Wang C, Alcalay RN, San Luciano M, Ortega R, Raymond D, Mejia-Santana H, Ozelius L, Clark L, Orr-Utreger A, Marder K, Giladi N, Bressman SB
• Effect of subthalamic nucleus deep brain stimulation on dual-task cognitive and motor performance in isolated dystonia.
  Journal of neurology, neurosurgery, and psychiatry 2014 Mills KA, Markun LC, San Luciano M, Rizk R, Allen IE, Racine CA, Starr PA, Alberts JL, Ostrem JL
• Caregiver burden in epilepsy: determinants and impact.
  Epilepsy research and treatment 2014 Karakis I, Cole AJ, Montouris GD, San Luciano M, Meador KJ, Piperidou C
• Heterogeneity in primary dystonia: lessons from THAP1, GNAL, and TOR1A in Amish-Mennonites.
  Movement disorders : official journal of the Movement Disorder Society 2014 Saunders-Pullman R, Fuchs T, San Luciano M, Raymond D, Brashear A, Ortega R, Deik A, Ozelius LJ, Bressman SB
• Parkinson disease phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations.
  Movement disorders : official journal of the Movement Disorder Society 2013 Alcalay RN, Mirelman A, Saunders-Pullman R, Tang MX, Mejia Santana H, Raymond D, Roos E, Orbe-Reilly M, Gurevich T, Bar Shira A, Gana Weisz M, Yasinovsky K, Zalis M, Thaler A, Deik A, Barrett MJ, …
• Focal task-specific lower extremity dystonia associated with intense repetitive exercise: a case series.
  Parkinsonism & related disorders 2013 Katz M, Byl NN, San Luciano M, Ostrem JL
• The utility of routine EEG in the diagnosis of sleep disordered breathing.
  Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2012 Karakis I, Chiappa KH, San Luciano M, Sassower KC, Stakes JW, Cole AJ
• Variant ataxia-telangiectasia presenting as primary-appearing dystonia in Canadian Mennonites.
  Neurology 2012 Saunders-Pullman R, Raymond D, Stoessl AJ, Hobson D, Nakamura K, Nakamura T, Pullman S, Lefton D, Okun MS, Uitti R, Sachdev R, Stanley K, San Luciano M, Hagenah J, Gatti R, Ozelius LJ, Bressman SB
• Gender differences in the IL6 -174G>C and ESR2 1730G>A polymorphisms and the risk of Parkinson's disease.
  Neuroscience letters 2011 San Luciano M, Ozelius L, Lipton RB, Raymond D, Bressman SB, Saunders-Pullman R
• Olfactory dysfunction in LRRK2 G2019S mutation carriers.
  Neurology 2011 Saunders-Pullman R, Stanley K, Wang C, San Luciano M, Shanker V, Hunt A, Severt L, Raymond D, Ozelius LJ, Lipton RB, Bressman SB
• Gender differences in the risk of familial parkinsonism: beyond LRRK2?
  Neuroscience letters 2011 Saunders-Pullman R, Stanley K, San Luciano M, Barrett MJ, Shanker V, Raymond D, Ozelius LJ, Bressman SB
• LRRK2 G2019S mutations may be increased in Puerto Ricans.
  Movement disorders : official journal of the Movement Disorder Society 2011 Saunders-Pullman R, Cabassa J, San Luciano M, Stanley K, Raymond D, Ozelius LJ, Bressman SB
• Clinical expression of LRRK2 G2019S mutations in the elderly.
  Movement disorders : official journal of the Movement Disorder Society 2010 San Luciano M, Lipton RB, Wang C, Katz M, Zimmerman ME, Sanders AE, Ozelius LJ, Bressman SB, Saunders-Pullman R
• Substantia nigra hyperechogenicity in DYT6 dystonia: a pilot study.
  Parkinsonism & related disorders 2010 Saunders-Pullman R, Stanley K, Brüggemann N, Raymond D, San Luciano M, Wang C, Klein C, Lubarr N, Ozelius L, Bressman SB, Hagenah J
• Clinical and neurophysiological improvement of SGCE myoclonus-dystonia with GPi deep brain stimulation.
  Clinical neurology and neurosurgery 2009 Kurtis MM, San Luciano M, Yu Q, Goodman RR, Ford B, Raymond D, Pullman SL, Saunders-Pullman R
• Substance abuse and movement disorders.
  Current drug abuse reviews 2009 San Luciano M, Saunders-Pullman R