Marlys Fassett, MD, PhD
Associate Professor
Dermatology
School of Medicine

Please call UCSF Dermatology at 415 353 7800 for clinical care inquiries or appointments. The telephone number listed here is not monitored.

Education & Training

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• DEI Training UNIVERSITY OF CALIFORNIA, SAN FRANCISCO 2019
• Residency Dermatology UNIVERSITY OF CALIFORNIA, SAN FRANCISCO 2015
• Internship Internal Medicine BIDMC/HARVARD MEDICAL SCHOOL 2012
• MD Medical Scientist Training Program (MSTP) HARVARD MEDICAL SCHOOL, HST 2011
• PHD Immunology HARVARD MEDICAL SCHOOL 2009
• AB mcl Biochemistry HARVARD COLLEGE 2001

Websites

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• Fassett Lab Website (fassettlab.ucsf.edu)

Grants and Projects

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• Illuminating IL-31-producing cells in allergic skin disease, NIH/NIAMS, 2023-2025
• Interleukin-31 at the neuroimmune interface of pruritus and dermatitis, NIH, 2019-2024
• Physician-Scientist Career Development Award, DERMATOLOGY FOUNDATION, 2017-2019
• Junior Faculty Pilot Award, UCSF PREMIER/MT ZION HEALTH FUND, 2018-2019
• Dermatologist Investigator Research Fellowship, DERMATOLOGY FOUNDATION, 2015-2016
• , NIH/NIAMS, 2014-2016
• Nur77 family transcription factors in T1DM immune tolerance and Treg differentiation, NIH/NIDDK, 2006-2008

Publications (26)

Top publication keywords:
MicroRNAsPrurigoChilblainsSkin DiseasesPruritusT-Lymphocytes, RegulatoryNeurogenic InflammationSkinHypersensitivityNuclear Receptor Subfamily 4, Group A, Member 1MitesDermatitis, AtopicPyroglyphidaeCervical VertebraeNeuroimmunomodulation

• IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis.
  Science immunology 2023 Fassett MS, Braz JM, Castellanos CA, Salvatierra JJ, Sadeghi M, Yu X, Schroeder AW, Caston J, Munoz-Sandoval P, Roy S, Lazarevsky S, Mar DJ, Zhou CJ, Shin JS, Basbaum AI, Ansel KM
• Evaluation of Gabapentin and Transforaminal Corticosteroid Injections for Brachioradial Pruritus.
  JAMA dermatology 2022 Gutierrez RA, Berger TG, Shah V, Agnihothri R, Demir-Deviren S, Fassett MS
• Cutaneous Pathology of COVID-19 as a Window into Immunologic Mechanisms of Disease.
  Dermatologic clinics 2021 Gallman AE, Fassett MS
• Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Braz JM, Dembo T, Charruyer A, Ghadially R, Fassett MS, Basbaum AI
• Long COVID in the skin: a registry analysis of COVID-19 dermatological duration.
  The Lancet. Infectious diseases 2021 McMahon DE, Gallman AE, Hruza GJ, Rosenbach M, Lipoff JB, Desai SR, French LE, Lim H, Cyster JG, Fox LP, Fassett MS, Freeman EE
• Neuroimmune interactions in chronic itch of atopic dermatitis.
  Journal of the European Academy of Dermatology and Venereology : JEADV 2019 Yosipovitch G, Berger T, Fassett MS
• A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.
  Nature immunology 2012 Fu W, Ergun A, Lu T, Hill JA, Haxhinasto S, Fassett MS, Gazit R, Adoro S, Glimcher L, Chan S, Kastner P, Rossi D, Collins JJ, Mathis D, Benoist C
• Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Fassett MS, Jiang W, D'Alise AM, Mathis D, Benoist C

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• Neuropeptide substance P alters stem cell fate to aid wound healing and promote epidermal stratification through asymmetric stem cell divisions.
  Stem cells (Dayton, Ohio) 2024 Khalifa A, Xiao T, Abegaze B, Weisenberger T, Charruyer A, Sanad S, AbuElnasr T, Kashem SW, Fassett M, Ghadially R
• An essential role for miR-15/16 in Treg suppression and restriction of proliferation.
  Cell reports 2023 Johansson K, Gagnon JD, Zhou SK, Fassett MS, Schroeder AW, Kageyama R, Bautista RA, Pham H, Woodruff PG, Ansel KM
• Can Serum Biomarkers for Prurigo Nodularis Expose Pathophysiology or Just Treatment Response?
  JAMA dermatology 2023 Kashem SW, Fassett MS
• Innate type 2 immunity controls hair follicle commensalism by Demodex mites.
  Immunity 2022 Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, …
• Obesity alters pathology and treatment response in inflammatory disease.
  Nature 2022 Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, …
• Incidence and Characteristics of Delayed Injection Site Reaction to the mRNA-1273 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine (Moderna) in a Cohort of Hospital Employees.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2022 Jacobson MA, Zakaria A, Maung Z, Hart C, McCalmont TH, Fassett M, Amerson E
• Varicella-zoster and herpes simplex virus reactivation post-COVID-19 vaccination: a review of 40 cases in an International Dermatology Registry.
  Journal of the European Academy of Dermatology and Venereology : JEADV 2021 Fathy RA, McMahon DE, Lee C, Chamberlin GC, Rosenbach M, Lipoff JB, Tyagi A, Desai SR, French LE, Lim HW, Thiers BH, Hruza GJ, Fassett M, Fox LP, Greenberg HL, Blumenthal K, Freeman EE
• Cold and COVID: recurrent pernio during the COVID-19 pandemic.
  The British journal of dermatology 2021 Freeman EE, McMahon DE, Lipoff JB, Rosenbach M, Desai SR, Fassett M, French LE, Lim HW, Hruza GJ, Fox LP
• Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation.
  iScience 2020 Liu Y, Cook C, Sedgewick AJ, Zhang S, Fassett MS, Ricardo-Gonzalez RR, Harirchian P, Kashem SW, Hanakawa S, Leistico JR, North JP, Taylor MA, Zhang W, Man MQ, Charruyer A, Beliakova-Bethell N, Benz SC…
• Timing of PCR and antibody testing in patients with COVID-19-associated dermatologic manifestations.
  Journal of the American Academy of Dermatology 2020 Freeman EE, McMahon DE, Hruza GJ, Lipoff JB, French LE, Fox LP, Fassett MS
• Treatment of PD-1/PD-L1 Inhibitor-Induced Dermatitis Resolves Concomitant Eruptive Keratoacanthomas.
  JAMA dermatology 2020 Crow LD, Perkins I, Twigg AR, Fassett MS, LeBoit PE, Berger TG, Khodosh R
• miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.
  Cell reports 2019 Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, …
• Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution.
  Cell reports 2018 Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu …
• Identification of Functionally Relevant microRNAs in the Regulation of Allergic Inflammation.
  Methods in molecular biology (Clifton, N.J.) 2018 Fassett MS, Pua HH, Simpson LJ, Steiner DF, Ansel KM
• The Immunological Genome Project: networks of gene expression in immune cells.
  Nature immunology 2008 Heng TS, Painter MW, Immunological Genome Project Consortium
• Viral evasion of natural killer cells.
  Nature immunology 2002 Orange JS, Fassett MS, Koopman LA, Boyson JE, Strominger JL
• Signaling at the inhibitory natural killer cell immune synapse regulates lipid raft polarization but not class I MHC clustering.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Fassett MS, Davis DM, Valter MM, Cohen GB, Strominger JL
• The human natural killer cell immune synapse.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Davis DM, Chiu I, Fassett M, Cohen GB, Mandelboim O, Strominger JL