Marlene Grenon, MD
Industry Alliance Specialist
Innovation Ventures
Chancellor/EVC/FAS

Dr. Marlene Grenon was born in Quebec, Canada. She obtained a diploma in space sciences from the International Space University (ISU) in 1998.

Show full bio (190 words) Hide full bio

She graduated from McGill Medical School in 2000 and obtained a Masters' degree from the Scholars in Clinical Science Program of Harvard Medical School along with a post-doctoral fellowship in cardiovascular space medicine and endocrinology from Brigham and Women's Hospital and the Massachusetts Institute of Technology (MIT) in 2004. She then completed training in cardiac surgery at McGill University in 2007, vascular surgery at the University of British Columbia in 2009 and endovascular surgery at the Arizona Heart Institute in 2010. She is a fellow from the Royal College of Physicians and Surgeons of Canada (RCPSC) and maintains a Certificate of Specialist in both cardiac and vascular surgery from RCPSC.

Dr. Grenon is presently an Associate Professor in the Department of Surgery at UCSF, a Staff surgeon at the VAMC San Francisco and an Adjunct Faculty at the International Space University. She is a member of many professional organizations and has been an invited lecturer at several regional, national and international meetings and conferences. She is the recipient of several awards for research and was one of the finalists in the 2009 Canadian Astronaut selection.

Education & Training

Show all (2) Hide

• Diversity, Equity, and Inclusion Champion Training University of California 2019
• Diversity, Equity, and Inclusion Champion Training University of California 2017

Interests

Show all (14) Hide

• Critical Limb Ischemia
• Diabetic Vascular Disease
• Dialysis Access
• Chronic Venous Insufficiency
• Carotid Artery Disease
• Endovascular Aneurysm Repair
• Mesenteric Artery Disease
• Complex Limb Revascularization
• Vascular Malformations
• Deep Vein Thrombosis
• Abdominal Aortic Aneurysm
• Peripheral Artery Disease
• Thoracic Aortic Aneurysm
• Varicose Veins

Videos

Show all (1) Hide

• UCSF Vascular Care Symposium - Screening for Ischemia in the Diabetic Foot: What is Best and How to Use the Information (youtube.com)

Grants and Projects

Show all (1) Hide

• Effects of fish oil on inflammation and vascular function in claudicants, NIH, 2014-2018

Publications (73)

Top publication keywords:
Dietary SupplementsVascular StiffnessEndothelium, VascularPeripheral Arterial DiseaseDocosahexaenoic AcidsBrachial ArteryVeterans HealthEicosapentaenoic AcidWeightlessness SimulationFish OilsIntermittent ClaudicationAnkle Brachial IndexFatty Acids, Omega-3VasodilationFatty Acids, Unsaturated

• Foundational Considerations for Artificial Intelligence Using Ophthalmic Images.
  Ophthalmology 2021 Abràmoff MD, Cunningham B, Patel B, Eydelman MB, Leng T, Sakamoto T, Blodi B, Grenon SM, Wolf RM, Manrai AK, Ko JM, Chiang MF, Char D, Collaborative Community on Ophthalmic Imaging Executive Committee…
• The Cupola: an additional layer of protection for providers working in the oropharyngeal region.
  BMC research notes 2021 Villa A, Grenon M
• Association of comorbid depression with inpatient outcomes in critical limb ischemia.
  Vascular medicine (London, England) 2019 Zahner GJ, Cortez A, Duralde E, Ramirez JL, Wang S, Hiramoto J, Cohen BE, Wolkowitz OM, Arya S, Hills NK, Grenon SM
• Predicting the effects of supplemental EPA and DHA on the omega-3 index.
  The American journal of clinical nutrition 2019 Walker RE, Jackson KH, Tintle NL, Shearer GC, Bernasconi A, Masson S, Latini R, Heydari B, Kwong RY, Flock M, Kris-Etherton PM, Hedengran A, Carney RM, Skulas-Ray A, Gidding SS, Dewell A, Gardner CD, …
• Peripheral Artery Disease Is Associated with a Deficiency of Erythrocyte Membrane n-3 Polyunsaturated Fatty Acids.
  Lipids 2019 Ramirez JL, Zahner GJ, Spaulding KA, Khetani SA, Hills NK, Gasper WJ, Harris WS, Cohen BE, Grenon SM

Show all (68 more) Hide

• Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial).
  The Journal of surgical research 2019 Ramirez JL, Gasper WJ, Khetani SA, Zahner GJ, Hills NK, Mitchell PT, Sansbury BE, Conte MS, Spite M, Grenon SM
• Leptinemia is Associated With Peripheral Artery Disease.
  The Journal of surgical research 2019 Zahner GJ, Ramirez JL, Spaulding KA, Khetani SA, Gasper WJ, Grunfeld C, Hills NK, Schafer AL, Grenon SM
• Scoping review of frailty in vascular surgery.
  Journal of vascular surgery 2018 Drudi LM, Ades M, Landry T, Gill HL, Grenon SM, Steinmetz OK, Afilalo J
• Serum resistin is associated with impaired endothelial function and a higher rate of adverse cardiac events in patients with peripheral artery disease.
  Journal of vascular surgery 2018 Ramirez JL, Khetani SA, Zahner GJ, Spaulding KA, Schaller MS, Gasper WJ, Hills NK, Schafer AL, Grenon SM
• Depression and peripheral artery disease: why we should care and what we can do.
  CVIR endovascular 2018 Ramirez JL, Grenon SM
• Depression severity is associated with increased inflammation in veterans with peripheral artery disease.
  Vascular medicine (London, England) 2018 Hernandez NV, Ramirez JL, Khetani SA, Spaulding KA, Gasper WJ, Hiramoto J, Lindqvist D, Wolkowitz OM, Hills NK, Grenon SM, Zahner GJ
• Review of biologic and behavioral risk factors linking depression and peripheral artery disease.
  Vascular medicine (London, England) 2018 Ramirez JL, Drudi LM, Grenon SM
• Frailty Is Associated with an Increased Risk of Major Adverse Cardiac Events in Patients with Stable Claudication.
  Annals of vascular surgery 2018 Schaller MS, Ramirez JL, Gasper WJ, Zahner GJ, Hills NK, Grenon SM
• The association of comorbid depression with mortality and amputation in veterans with peripheral artery disease.
  Journal of vascular surgery 2018 Arya S, Lee S, Zahner GJ, Cohen BE, Hiramoto J, Wolkowitz OM, Khakharia A, Binney ZO, Grenon SM
• Characterizing the relationship between flow-mediated vasodilation and radial artery tonometry in peripheral artery disease.
  The Journal of surgical research 2017 Zahner GJ, Spaulding KA, Ramirez JL, Schaller MS, Walker SC, Hills NK, Gasper WJ, Grenon SM
• Increased circulating blood cell counts in combat-related PTSD: Associations with inflammation and PTSD severity.
  Psychiatry research 2017 Lindqvist D, Mellon SH, Dhabhar FS, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Aschbacher K, Bersani FS, Marmar CR, Wolkowitz OM
• Association between arterial stiffness and peripheral artery disease as measured by radial artery tonometry.
  Journal of vascular surgery 2017 Zahner GJ, Gruendl MA, Spaulding KA, Schaller MS, Hills NK, Gasper WJ, Grenon SM
• Relationship between the omega-3 index and specialized pro-resolving lipid mediators in patients with peripheral arterial disease taking fish oil supplements.
  Journal of clinical lipidology 2017 Schaller MS, Zahner GJ, Gasper WJ, Harris WS, Conte MS, Hills NK, Grenon SM
• Predictors of change in omega-3 index with fish oil supplementation in peripheral artery disease.
  The Journal of surgical research 2016 Drudi LM, Schaller MS, Hiramoto J, Gasper W, Harris WS, Hills NK, Grenon SM
• Increased pro-inflammatory milieu in combat related PTSD - A new cohort replication study.
  Brain, behavior, and immunity 2016 Lindqvist D, Dhabhar FS, Mellon SH, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Bersani FS, Marmar CR, Wolkowitz OM
• Chronic stress is associated with reduced circulating hematopoietic progenitor cell number: A maternal caregiving model.
  Brain, behavior, and immunity 2016 Aschbacher K, Milush JM, Gilbert A, Almeida C, Sinclair E, Epling L, Grenon SM, Marco EJ, Puterman E, Epel E
• Posttraumatic Stress Disorder Is Associated With Worse Endothelial Function Among Veterans.
  Journal of the American Heart Association 2016 Grenon SM, Owens CD, Alley H, Perez S, Whooley MA, Neylan TC, Aschbacher K, Gasper WJ, Hilton JF, Cohen BE
• Short-Term, High-Dose Fish Oil Supplementation Increases the Production of Omega-3 Fatty Acid-Derived Mediators in Patients With Peripheral Artery Disease (the OMEGA-PAD I Trial).
  Journal of the American Heart Association 2015 Grenon SM, Owens CD, Nosova EV, Hughes-Fulford M, Alley HF, Chong K, Perez S, Yen PK, Boscardin J, Hellmann J, Spite M, Conte MS
• A Rising Generation of Diversity in the Vascular Surgery Workforce.
  Annals of vascular surgery 2015 Itoga NK, Woo K, Bismuth J, Bechara CF, Grenon M, Mitchell E, Zhou W
• Analysis of nutritional habits and intake of polyunsaturated fatty acids in veterans with peripheral arterial disease.
  Vascular medicine (London, England) 2015 Nosova EV, Bartel K, Chong KC, Alley HF, Conte MS, Owens CD, Grenon SM
• Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Chang TT, Spurlock SM, Candelario TL, Grenon SM, Hughes-Fulford M
• Advancing beyond the "heart-healthy diet" for peripheral arterial disease.
  Journal of vascular surgery 2015 Nosova EV, Conte MS, Grenon SM
• Ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery in clinical research.
  Journal of visualized experiments : JoVE 2014 Alley H, Owens CD, Gasper WJ, Grenon SM
• Relationship between kidney disease and endothelial function in peripheral artery disease.
  Journal of vascular surgery 2014 Chong KC, Owens CD, Park M, Alley HF, Boscardin WJ, Conte MS, Gasper WJ, Grenon SM
• Ferumoxytol-enhanced magnetic resonance angiography is a feasible method for the clinical evaluation of lower extremity arterial disease.
  Annals of vascular surgery 2014 Walker JP, Nosova E, Sigovan M, Rapp J, Grenon MS, Owens CD, Gasper WJ, Saloner DA
• Clinical correlates of red blood cell omega-3 fatty acid content in male veterans with peripheral arterial disease.
  Journal of vascular surgery 2014 Nosova EV, Chong KC, Alley HF, Harris WS, Boscardin WJ, Conte MS, Owens CD, Grenon SM
• Women's health in spaceflight.
  Aviation, space, and environmental medicine 2014 Drudi L, Grenon SM
• Peripheral arterial disease, gender, and depression in the Heart and Soul Study.
  Journal of vascular surgery 2014 Grenon SM, Cohen BE, Smolderen K, Vittinghoff E, Whooley MA, Hiramoto J
• Short-term physical inactivity impairs vascular function.
  The Journal of surgical research 2014 Nosova EV, Yen P, Chong KC, Alley HF, Stock EO, Quinn A, Hellmann J, Conte MS, Owens CD, Spite M, Grenon SM
• Safety and feasibility of adjunctive dexamethasone infusion into the adventitia of the femoropopliteal artery following endovascular revascularization.
  Journal of vascular surgery 2014 Owens CD, Gasper WJ, Walker JP, Alley HF, Conte MS, Grenon SM
• Walking disability in patients with peripheral artery disease is associated with arterial endothelial function.
  Journal of vascular surgery 2014 Grenon SM, Chong K, Alley H, Nosova E, Gasper W, Hiramoto J, Boscardin WJ, Owens CD
• n-3 polyunsaturated fatty acids to heal the broken heart
  Clinical Lipidology 2013 Grenon SM, Conte MS
• n-3 Polyunsaturated fatty acids supplementation in peripheral artery disease: the OMEGA-PAD trial.
  Vascular medicine (London, England) 2013 Grenon SM, Owens CD, Alley H, Chong K, Yen PK, Harris W, Hughes-Fulford M, Conte MS
• Peripheral artery disease and risk of cardiovascular events in patients with coronary artery disease: insights from the Heart and Soul Study.
  Vascular medicine (London, England) 2013 Grenon SM, Vittinghoff E, Owens CD, Conte MS, Whooley M, Cohen BE
• Association between n-3 polyunsaturated fatty acid content of red blood cells and inflammatory biomarkers in patients with peripheral artery disease.
  Journal of vascular surgery 2013 Grenon SM, Conte MS, Nosova E, Alley H, Chong K, Harris WS, Vittinghoff E, Owens CD
• Assessing the anatomic applicability of the multibranched endovascular repair of thoracoabdominal aortic aneurysm technique.
  Journal of vascular surgery 2013 Gasper WJ, Reilly LM, Rapp JH, Grenon SM, Hiramoto JS, Sobel JD, Chuter TA
• Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation and adhesion molecules.
  Scientific reports 2013 Grenon SM, Jeanne M, Aguado-Zuniga J, Conte MS, Hughes-Fulford M
• Can I take a space flight? Considerations for doctors.
  BMJ (Clinical research ed.) 2012 Grenon SM, Saary J, Gray G, Vanderploeg JM, Hughes-Fulford M
• Untitled Publication
  2012 S. Marlene Grenon, Chad Ball, Joan Saary and Andy W. Kirkpatrick. Surgery in Space. Editors J Wong and J Pelton. LAP Lambert Academic Publishing. ISBN 978-3-659-26581-5
• J Am Heart Assoc. (published online August 30th 2012)
  In response to: "Low serum 25-hydroxyvitamin D concentrations may explain the link between depression and peripheral artery disease" 2012 Grenon SM, Cohen BE.
• Association between depression and peripheral artery disease: insights from the heart and soul study.
  Journal of the American Heart Association 2012 Grenon SM, Hiramoto J, Smolderen KG, Vittinghoff E, Whooley MA, Cohen BE
• Efficacy and durability of endovascular thoracoabdominal aortic aneurysm repair using the caudally directed cuff technique.
  Journal of vascular surgery 2012 Reilly LM, Rapp JH, Grenon SM, Hiramoto JS, Sobel J, Chuter TA
• Effects of fatty acids on endothelial cells: inflammation and monocyte adhesion.
  The Journal of surgical research 2012 Grenon SM, Aguado-Zuniga J, Hatton JP, Owens CD, Conte MS, Hughes-Fulford M
• Polyunsaturated fatty acids and peripheral artery disease.
  Vascular medicine (London, England) 2012 Grenon SM, Hughes-Fulford M, Rapp J, Conte MS
• Surgery in Space: Where are we at now?
  Acta astronautica 2012 Drudi L, Ball CG, Kirkpatrick AW, Saary J, Grenon SM
• Challenges in aerospace medicine education.
  Aviation, space, and environmental medicine 2011 Grenon SM, Saary J
• A late complication of migration after aortic endografting: injury to the superior mesenteric artery.
  Journal of vascular and interventional radiology : JVIR 2011 Grenon SM, Reid JD, Clement J
• Technical endovascular highlights for crossing the difficult aortic bifurcation.
  Journal of vascular surgery 2011 Grenon SM, Reilly LM, Ramaiah VG
• Aspirin prophylaxis (100 mg daily) does not improve cardiovascular outcomes compared to placebo in asymptomatic individuals with incidental low-ankle brachial index.
  Evidence-based medicine 2010 Grenon SM, Conte MS
• The use of the National Research Council of Canada's Falcon 20 research aircraft as a terrestrial analogue space environment (TASE) for space surgery research: Challenges and suggested solutions. Planetary and Space Science 58, 717-723,
  The use of the National Research Council of Canada's Falcon 20 research aircraft as a terrestrial analogue space environment (TASE) for space surgery research: Challenges and suggested solutions. Planetary and Space Science 58, 717-723, 2010 Kirkpatrick AW, Keaney MA, Bentz K, Groleau M, Tyssen M, Keyte J, Ball CG, Campbell MR, Grenon SM, McBeth P, Broderick TJ.
• Occlusion of the common and internal iliac arteries for aortoiliac aneurysm repair: experience with the Amplatzer vascular plug.
  Canadian journal of surgery. Journal canadien de chirurgie 2009 Grenon SM, Gagnon J, Hsiang Y, Sidhu R, Taylor D, Clement J, Chen J
• Video in clinical medicine. Ankle-brachial index for assessment of peripheral arterial disease.
  The New England journal of medicine 2009 Grenon SM, Gagnon J, Hsiang Y
• Canadian experience with percutaneous endovascular aneurysm repair: short-term outcomes.
  Canadian journal of surgery. Journal canadien de chirurgie 2009 Grenon SM, Gagnon J, Hsiang YN, Chen JC
• Use of short-radius centrifugation to augment ankle-brachial indices.
  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2009 Grenon SM, Mateus J, Hsiang Y, Sidhu R, Young L, Gagnon J
• Endovascular aortic aneurysm repair via the left ventricular apex of a beating heart.
  Journal of vascular surgery 2009 MacDonald S, Cheung A, Sidhu R, Rheaume P, Grenon SM, Clement J
• Successful ventricular transapical thoracic endovascular graft deployment in a pig model.
  Journal of vascular surgery 2008 Grenon SM, MacDonald S, Sidhu RS, Reid JD, Cheung A, Hsiang Y, Clement J
• A type IV paraesophageal hernia containing a volvulized sigmoid colon.
  Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 2008 Grushka JR, Grenon SM, Ferri LE
• Surgical strategies for severe calcification of the aorta (porcelain aorta) in two patients with homozygous familial hypercholesterolemia.
  The Canadian journal of cardiology 2007 Grenon SM, Lachapelle K, Marcil M, Omeroglu A, Genest J, de Varennes B
• Combined simultaneous heart and liver transplantation with complete cardiopulmonary bypass support.
  The Annals of thoracic surgery 2007 Bernier PL, Grenon M, Ergina P, Schricker T, Chaudhury P, Metrakos P, Lachapelle K
• Why is orthostatic tolerance lower in women than in men? Renal and cardiovascular responses to simulated microgravity and the role of midodrine.
  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2006 Grenon SM, Xiao X, Hurwitz S, Sheynberg N, Kim C, Seely EW, Cohen RJ, Williams GH
• Bed rest effects on human calf hemodynamics and orthostatic intolerance: a model-based analysis.
  Aviation, space, and environmental medicine 2005 Xiao X, Grenon SM, Kim C, Sheynberg N, Hurwitz S, Williams GH, Cohen RJ
• Simulated microgravity induces microvolt T wave alternans.
  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 2005 Grenon SM, Xiao X, Hurwitz S, Ramsdell CD, Sheynberg N, Kim C, Williams GH, Cohen RJ
• Readaptation from simulated microgravity as a stimulus for improved orthostatic tolerance: role of the renal, cardioendocrine, and cardiovascular systems.
  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2005 Grenon SM, Hurwitz S, Xiao X, Sheynberg N, Ramsdell CD, Kim C, Cohen RJ, Williams GH
• Sleep restriction does not affect orthostatic tolerance in the simulated microgravity environment.
  Journal of applied physiology (Bethesda, Md. : 1985) 2004 Grenon SM, Hurwitz S, Sheynberg N, Xiao X, Judson B, Ramsdell CD, Kim C, Cohen RJ, Williams GH
• Role of individual predisposition in orthostatic intolerance before and after simulated microgravity.
  Journal of applied physiology (Bethesda, Md. : 1985) 2004 Grenon SM, Hurwitz S, Sheynberg N, Xiao X, Ramsdell CD, Mai CL, Kim C, Cohen RJ, Williams GH
• Renal, endocrine, and cardiovascular responses to bed rest in male subjects on a constant diet.
  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2004 Grenon SM, Sheynberg N, Hurwitz S, Xiao G, Ramsdell CD, Ehrman MD, Mai CL, Kristjansson SR, Sundby GH, Cohen RJ, Williams GH
• Effects of simulated microgravity on closed-loop cardiovascular regulation and orthostatic intolerance: analysis by means of system identification.
  Journal of applied physiology (Bethesda, Md. : 1985) 2003 Xiao X, Mukkamala R, Sheynberg N, Grenon SM, Ehrman MD, Mullen TJ, Ramsdell CD, Williams GH, Cohen RJ
• Psuedoaneurysm of the superficial femoral artery resulting from stingray envenomation.
  Annals of vascular surgery 2003 Campbell J, Grenon M, You CK