Markus Delling, PhD
Associate Professor
Physiology
School of Medicine

Websites

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• Delling Lab (dellinglab.ucsf.edu)

Grants and Projects

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• A comprehensive map of polycystin channel regulation and its implications in polycystic kidney disease, NIH, 2021-2025
• Regulation and functional characterization of ciliary calcium signaling, NIH, 2019-2023
• Polycystin activators as novel therapeutic approach for ADPKD, NIH, 2021-2023

Publications (37)

Top publication keywords:
Neural Cell Adhesion MoleculesCalcium ChannelsBody PatterningTRPM Cation ChannelsPatch-Clamp TechniquesCell MembraneDatabases, PharmaceuticalCiliaPharmacologyMechanotransduction, CellularPolycystic Kidney, Autosomal DominantHedgehog ProteinsTRPP Cation ChannelsCalcium SignalingOrganelles

• Cilia-enriched oxysterol 7β,27-DHC is required for polycystin ion channel activation.
  Nature communications 2024 Ha K, Mundt-Machado N, Bisignano P, Pinedo A, Raleigh DR, Loeb G, Reiter JF, Cao E, Delling M
• ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function.
  bioRxiv : the preprint server for biology 2023 Ha K, Loeb GB, Park M, Pinedo A, Park CH, Brandes N, Ritu F, Ye CJ, Reiter JF, Delling M
• The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.
  British journal of pharmacology 2023 Alexander SPH, Mathie AA, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Caceres AI, …
• Testing the ion-current model for flagellar length sensing and IFT regulation.
  eLife 2023 Ishikawa H, Moore J, Diener DR, Delling M, Marshall WF
• Conversion of anterograde into retrograde trains is an intrinsic property of intraflagellar transport.
  Current biology : CB 2022 Nievergelt AP, Zykov I, Diener D, Chhatre A, Buchholz TO, Delling M, Diez S, Jug F, Štepánek L, Pigino G

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• Electrophysiological Recordings of the Polycystin Complex in the Primary Cilium of Cultured Mouse IMCD-3 Cell Line.
  Bio-protocol 2021 Ha K, Delling M
• THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels.
  British journal of pharmacology 2021 Alexander SP, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill …
• The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus.
  eLife 2020 Ha K, Nobuhara M, Wang Q, Walker RV, Qian F, Schartner C, Cao E, Delling M
• New insights into ion channel-dependent signalling during left-right patterning.
  The Journal of physiology 2019 Tajhya R, Delling M
• Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia.
  eLife 2018 McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD
• MCOLN1 is a ROS sensor in lysosomes that regulates autophagy.
  Nature communications 2016 Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, Hu X, Gao Q, Yang M, Lawas M, Delling M, Marugan J, Ferrer M, Xu H
• Primary cilia are not calcium-responsive mechanosensors.
  Nature 2016 Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE
• Ion channels and calcium signaling in motile cilia.
  eLife 2015 Doerner JF, Delling M, Clapham DE
• Direct Recording and Molecular Identification of the Calcium Channel of Primary Cilia.
  Biophysical Journal 2014 Paul G. DeCaen, Markus Delling, David E. Clapham
• Direct recording and molecular identification of the calcium channel of primary cilia.
  Nature 2013 DeCaen PG, Delling M, Vien TN, Clapham DE
• Primary cilia are specialized calcium signalling organelles.
  Nature 2013 Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE
• Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA
• Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis.
  Developmental cell 2012 Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE
• Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE
• PI(3,5)P2 Controls Membrane Trafficking by Direct Activation of Mucolipin Ca2+ Release Channels in the Endolysosome.
  Biophysical Journal 2011 Xiang Wang, Xianping Dong, Dongbiao Shen, Taylor Dawson, Xinran Li, Qi Zhang, Xiping Cheng, Yanling Zhang, Lois S. Weisman, Markus Delling, Haoxing Xu
• PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome.
  Nature communications 2010 Dong XP, Shen D, Wang X, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman LS, Delling M, Xu H
• Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis.
  The Journal of biological chemistry 2009 Dong XP, Wang X, Shen D, Chen S, Liu M, Wang Y, Mills E, Cheng X, Delling M, Xu H
• Activation Mutations of the TRPML1 Channel Revealed by Proline Scanning Mutagenesis.
  Biophysical Journal 2009 Xiang Wang, Xianping Dong, Su Chen, Dongbiao Shen, Meiling Liu, Eric Mills, Xiping Cheng, Markus Delling, Haoxing Xu
• The Type IV Mucolipidosis-Associated Protein TRPML1 is an Endolysosomal Iron Release Channel.
  Biophysical Journal 2009 Xian-Ping Dong, Xiping Cheng, Eric Mills, Markus Delling, Fudi Wang, Tino Kurz, Haoxing Xu
• The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel.
  Nature 2008 Dong XP, Cheng X, Mills E, Delling M, Wang F, Kurz T, Xu H
• Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A
• Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Xu H, Delling M, Li L, Dong X, Clapham DE
• Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels.
  Nature neuroscience 2006 Xu H, Delling M, Jun JC, Clapham DE
• An introduction to TRP channels.
  Annual review of physiology 2006 Ramsey IS, Delling M, Clapham DE
• The Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells.
  Membrane Microdomain Signaling 2005 Markus Delling, Melitta Schachner
• Polysialylated neural cell adhesion molecule promotes remodeling and formation of hippocampal synapses.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Dityatev A, Dityateva G, Sytnyk V, Delling M, Toni N, Nikonenko I, Muller D, Schachner M
• Rapid and efficient electroporation-based gene transfer into primary dissociated neurons.
  Journal of neuroscience methods 2003 Dityateva G, Hammond M, Thiel C, Ruonala MO, Delling M, Siebenkotten G, Nix M, Dityatev A
• Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuron-to-neuron contacts.
  The Journal of cell biology 2002 Sytnyk V, Leshchyns'ka I, Delling M, Dityateva G, Dityatev A, Schachner M
• The neural cell adhesion molecule regulates cell-surface delivery of G-protein-activated inwardly rectifying potassium channels via lipid rafts.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Delling M, Wischmeyer E, Dityatev A, Sytnyk V, Veh RW, Karschin A, Schachner M
• What can we learn from explanted endovascular devices?
  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2002 Riepe G, Heintz C, Kaiser E, Chakfé N, Morlock M, Delling M, Imig H
• Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis.
  The Journal of cell biology 2002 Niethammer P, Delling M, Sytnyk V, Dityatev A, Fukami K, Schachner M
• Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice.
  Journal of neurobiology 1999 Stork O, Welzl H, Wotjak CT, Hoyer D, Delling M, Cremer H, Schachner M